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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:TRA2A-ATP2A2 (FusionGDB2 ID:93573)

Fusion Gene Summary for TRA2A-ATP2A2

Fusion gene summary

Fusion gene information	Fusion gene name: TRA2A-ATP2A2
	Fusion gene ID: 93573
		Hgene	Tgene
	Gene symbol	TRA2A	ATP2A2
	Gene ID	29896	488
	Gene name	transformer 2 alpha homolog	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
	Synonyms	AWMS1\|HSU53209	ATP2B\|DAR\|DD\|SERCA2
	Cytomap	7p15.3	12q24.11
	Type of gene	protein-coding	protein-coding
	Description	transformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog A	sarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slow
	Modification date	20200313	20200313
	UniProtAcc	.	P16615
	Ensembl transtripts involved in fusion gene	ENST00000297071, ENST00000392502, ENST00000538367, ENST00000474586,	ENST00000552636, ENST00000550248, ENST00000308664, ENST00000395494, ENST00000539276,
Fusion gene scores	* DoF score	20 X 14 X 9=2520	19 X 23 X 6=2622
	# samples	24	23
	** MAII score	log2(24/2520*10)=-3.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/2622*10)=-3.51096191927738 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TRA2A [Title/Abstract] AND ATP2A2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TRA2A(23571407)-ATP2A2(110729824), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TRA2A	GO:0000398	mRNA splicing, via spliceosome	9546399
Tgene	ATP2A2	GO:0032469	endoplasmic reticulum calcium ion homeostasis	16402920
Tgene	ATP2A2	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	16402920
Tgene	ATP2A2	GO:0070588	calcium ion transmembrane transport	16402920
Tgene	ATP2A2	GO:1903515	calcium ion transport from cytosol to endoplasmic reticulum	16402920

Fusion gene breakpoints across TRA2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP2A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A43M	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+

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Fusion Gene ORF analysis for TRA2A-ATP2A2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000297071	ENST00000552636	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5CDS-intron	ENST00000297071	ENST00000550248	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5UTR-3CDS	ENST00000392502	ENST00000308664	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5UTR-3CDS	ENST00000392502	ENST00000395494	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5UTR-3CDS	ENST00000392502	ENST00000539276	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5UTR-3CDS	ENST00000538367	ENST00000308664	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5UTR-3CDS	ENST00000538367	ENST00000395494	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5UTR-3CDS	ENST00000538367	ENST00000539276	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5UTR-5UTR	ENST00000392502	ENST00000552636	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5UTR-5UTR	ENST00000538367	ENST00000552636	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5UTR-intron	ENST00000392502	ENST00000550248	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
5UTR-intron	ENST00000538367	ENST00000550248	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
In-frame	ENST00000297071	ENST00000308664	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
In-frame	ENST00000297071	ENST00000395494	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
In-frame	ENST00000297071	ENST00000539276	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
intron-3CDS	ENST00000474586	ENST00000308664	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
intron-3CDS	ENST00000474586	ENST00000395494	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
intron-3CDS	ENST00000474586	ENST00000539276	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
intron-5UTR	ENST00000474586	ENST00000552636	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+
intron-intron	ENST00000474586	ENST00000550248	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000297071	TRA2A	chr7	23571407	-	ENST00000308664	ATP2A2	chr12	110729824	+	3813	253	217	3027	936
ENST00000297071	TRA2A	chr7	23571407	-	ENST00000395494	ATP2A2	chr12	110729824	+	7700	253	217	3081	954
ENST00000297071	TRA2A	chr7	23571407	-	ENST00000539276	ATP2A2	chr12	110729824	+	4019	253	217	3162	981

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000297071	ENST00000308664	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+	0.000400105	0.9995999
ENST00000297071	ENST00000395494	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+	0.000422041	0.99957794
ENST00000297071	ENST00000539276	TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+	0.000305758	0.9996942

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Fusion Genomic Features for TRA2A-ATP2A2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+	3.76E-09	1
TRA2A	chr7	23571407	-	ATP2A2	chr12	110729824	+	3.76E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TRA2A-ATP2A2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:23571407/chr12:110729824)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ATP2A2 P16615
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). {ECO:0000269\|PubMed:16402920, ECO:0000269\|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250\|UniProtKB:O55143}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

111_253

998.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

274_295

998.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

314_756

998.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

70_89

998.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

777_786

998.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

808_827

998.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

851_896

998.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

917_929

998.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

949_963

998.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

985_1042

998.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

111_253

1016.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

274_295

1016.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

314_756

1016.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

70_89

1016.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

777_786

1016.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

808_827

1016.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

851_896

1016.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

917_929

1016.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

949_963

1016.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

985_1042

1016.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

111_253

1043.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

274_295

1043.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

314_756

1043.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

70_89

1043.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

777_786

1043.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

808_827

1043.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

851_896

1043.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

917_929

1043.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

949_963

1043.0

Topological domain

Lumenal

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

985_1042

1043.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

254_273

998.0

Transmembrane

Helical%3B Name%3D3

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

296_313

998.0

Transmembrane

Helical%3B Name%3D4

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

757_776

998.0

Transmembrane

Helical%3B Name%3D5

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

828_850

998.0

Transmembrane

Helical%3B Name%3D7

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

897_916

998.0

Transmembrane

Helical%3B Name%3D8

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

90_110

998.0

Transmembrane

Helical%3B Name%3D2

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

930_948

998.0

Transmembrane

Helical%3B Name%3D9

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

964_984

998.0

Transmembrane

Helical%3B Name%3D10

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

254_273

1016.0

Transmembrane

Helical%3B Name%3D3

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

296_313

1016.0

Transmembrane

Helical%3B Name%3D4

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

757_776

1016.0

Transmembrane

Helical%3B Name%3D5

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

828_850

1016.0

Transmembrane

Helical%3B Name%3D7

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

897_916

1016.0

Transmembrane

Helical%3B Name%3D8

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

90_110

1016.0

Transmembrane

Helical%3B Name%3D2

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

930_948

1016.0

Transmembrane

Helical%3B Name%3D9

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

964_984

1016.0

Transmembrane

Helical%3B Name%3D10

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

254_273

1043.0

Transmembrane

Helical%3B Name%3D3

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

296_313

1043.0

Transmembrane

Helical%3B Name%3D4

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

757_776

1043.0

Transmembrane

Helical%3B Name%3D5

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

828_850

1043.0

Transmembrane

Helical%3B Name%3D7

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

897_916

1043.0

Transmembrane

Helical%3B Name%3D8

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

90_110

1043.0

Transmembrane

Helical%3B Name%3D2

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

930_948

1043.0

Transmembrane

Helical%3B Name%3D9

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

964_984

1043.0

Transmembrane

Helical%3B Name%3D10

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TRA2A

chr7:23571407

chr12:110729824

ENST00000297071

226_282

283.0

Compositional bias

Note=Arg/Ser-rich (RS2 domain)

Hgene

TRA2A

chr7:23571407

chr12:110729824

ENST00000297071

30_112

283.0

Compositional bias

Note=Arg/Ser-rich (RS1 domain)

Hgene

TRA2A

chr7:23571407

chr12:110729824

ENST00000297071

119_197

283.0

Domain

RRM

Hgene

TRA2A

chr7:23571407

chr12:110729824

ENST00000297071

198_225

283.0

Region

Note=Linker

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

1_48

998.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

1_48

1016.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

1_48

1043.0

Topological domain

Cytoplasmic

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000308664

49_69

998.0

Transmembrane

Helical%3B Name%3D1

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000395494

49_69

1016.0

Transmembrane

Helical%3B Name%3D1

Tgene

ATP2A2

chr7:23571407

chr12:110729824

ENST00000539276

49_69

1043.0

Transmembrane

Helical%3B Name%3D1

Top

Fusion Gene Sequence for TRA2A-ATP2A2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>93573_93573_1_TRA2A-ATP2A2_TRA2A_chr7_23571407_ENST00000297071_ATP2A2_chr12_110729824_ENST00000308664_length(transcript)=3813nt_BP=253nt
GCCCGCCCCCTTTACGTCGTGCTCTGAGGAGGCCAGGAGATTTCTGGCGGCGCCGGCGCCATTTTGCTGGAGCCTGCGACCGAGTGGGAG
TGGAGTGGAGCGGCTGTGGTTGCCGACTCTTTCCTCTTCCCCACGGTCCAGTCAGCGGGTTAATTAGGCCATCGGCCCTCGAGCCGAGAC
TTGTCTCTTATTTAGTTCTGGGGAGCGCCTCGTCGACATGAGTGATGTGGAGGAAAACAACTTCGAGGGCAGAGTTTTGGCTTGGTTTGA
AGAAGGTGAAGAAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGA
AAGAAATGCTGAAAATGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCG
GATTAAAGCTAAAGACATAGTTCCTGGTGATATTGTAGAAATTGCTGTTGGTGACAAAGTTCCTGCTGATATAAGGTTAACTTCCATCAA
ATCTACCACACTAAGAGTTGACCAGTCAATTCTCACAGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGACCCACGAGC
TGTCAACCAAGATAAAAAGAACATGCTGTTTTCTGGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAACTGGAGTTAA
CACCGAAATTGGCAAGATCCGGGATGAAATGGTGGCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATTTGGGGAACA
GCTTTCCAAAGTCATCTCCCTTATTTGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGGGTCCTGGAT
CAGAGGTGCTATTTACTACTTTAAAATTGCAGTGGCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCACCACCTGCCT
GGCTCTTGGAACTCGCAGAATGGCAAAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTCTGTTATCTG
CTCAGACAAGACTGGTACACTTACAACAAACCAGATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATACTTGTTCCCT
TAATGAGTTTACCATAACTGGATCAACTTATGCACCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCAGTATGATGG
TCTGGTAGAATTAGCAACAATTTGTGCTCTTTGTAATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAAAGTTGGAGA
AGCTACAGAGACTGCTCTCACTTGCCTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGAACGTGCAAA
TGCCTGCAACTCAGTCATTAAACAGCTGATGAAAAAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGTTTACTGTAC
ACCAAATAAACCAAGCAGGACATCAATGAGCAAGATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCACATTCGAGT
TGGAAGTACTAAGGTTCCTATGACCTCTGGAGTCAAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGACACACTGCG
ATGCCTGGCCCTGGCCACTCATGACAACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATATGAGACCAA
TCTGACCTTCGTTGGCTGCGTGGGCATGCTGGATCCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGCAGGCATCCG
GGTCATCATGATCACTGGGGACAACAAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGACGTGACGTC
AAAAGCTTTCACAGGCCGGGAGTTTGATGAACTCAACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGCTCGAGTTGA
ACCCTCCCACAAGTCTAAAATCGTAGAATTTCTTCAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGATGCTCCTGC
TCTGAAGAAAGCCGAGATTGGCATTGCTATGGGCTCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGATGACAACTT
CTCCACCATTGTGGCTGCCGTTGAGGAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTCCAACGTCGG
GGAAGTTGTCTGTATTTTCCTGACAGCAGCCCTTGGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCTGGTGACAGA
TGGCCTGCCTGCCACTGCACTGGGGTTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACCATTGATCAG
CGGGTGGCTCTTTTTCCGTTACTTGGCTATTGGCTGTTACGTCGGCGCTGCTACCGTGGGTGCTGCTGCATGGTGGTTCATTGCTGCTGA
CGGTGGTCCAAGAGTGTCCTTCTACCAGCTGAGTCATTTCCTACAGTGTAAAGAGGACAACCCGGACTTTGAAGGCGTGGATTGTGCAAT
CTTTGAATCCCCATACCCGATGACAATGGCGCTCTCTGTTCTAGTAACTATAGAAATGTGTAACGCCCTCAACAGCTTGTCCGAAAACCA
GTCCTTGCTGAGGATGCCCCCCTGGGAGAACATCTGGCTCGTGGGCTCCATCTGCCTGTCCATGTCACTCCACTTCCTGATCCTCTATGT
CGAACCCTTGCCACTCATCTTCCAGATCACACCGCTGAACGTGACCCAGTGGCTGATGGTGCTGAAAATCTCCTTGCCCGTGATTCTCAT
GGATGAGACGCTCAAGTTTGTGGCCCGCAACTACCTGGAACCTGCAATACTGGAGTAACCGCTTCCTAAACCATTTTGCAGAAATGTAAG
GGTGTTCGGTTGCGTGCATGTGCGTTTTTAGCAACACATCTACCAACCCTGTGCATGACTGATGTTGGGGAAAAAGAAAAGTAAAAAACT
TCCCAACTCACTTTGTGTTATGTGGAGGAAATGTGTATTACCAATGGGGTTGTTAGCTTTTAAATCAAAATACTGATTACAGATGTACAA
TTTAGCTTAATCAGAAAGCCTCTCCAGAGAAGTTTGGTTTCTTTGCTGCAAGAGGAATGAGGCTCTGTAACCTTATCTAAGAACTTGGAA
GCCGTCAGCCAAGTCGCCACATTTCTCTGCAAAATGTCATAGCTTATATAAATGTACAGTATTCAATTGTAATGCATGCCTTCGGTTGTA
AGTAGCCAGATCCCTCTCCAGTGACATTGGAACATGCTACTTTTTAATTGGCCCTGTACAGTTTGCTTATTTATAAATTCATTAAAAACA
CTACAGGTGTTGAATGGTTAAAATGTAGGCCTCCAGTTCATTTTCAGTTATTTTCTGAGTGTGCAGACAGCTATTTCGCACTGTATTAAA
TGTAACTTATTTAATGAAATCAGAAGCAGTAGACAGATGTTGGTGCAATACAAATATTGTGATGCATTTATCTTAATAAAATGCTAAATG
TCAATTTATCACTGCGCATGTTTGACTTTAGACTGTAAATAGAGATCAGTTTGTTTCTTTCTGTGCTGGTAACAATGAGCGTCGCACAGA

>93573_93573_1_TRA2A-ATP2A2_TRA2A_chr7_23571407_ENST00000297071_ATP2A2_chr12_110729824_ENST00000308664_length(amino acids)=936AA_BP=12
MSDVEENNFEGRVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIV
EIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVA
TEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNA
IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCN
DSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKM
FVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDP
PRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQ
SFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALG
FPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSH
FLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPL

--------------------------------------------------------------
>93573_93573_2_TRA2A-ATP2A2_TRA2A_chr7_23571407_ENST00000297071_ATP2A2_chr12_110729824_ENST00000395494_length(transcript)=7700nt_BP=253nt
GCCCGCCCCCTTTACGTCGTGCTCTGAGGAGGCCAGGAGATTTCTGGCGGCGCCGGCGCCATTTTGCTGGAGCCTGCGACCGAGTGGGAG
TGGAGTGGAGCGGCTGTGGTTGCCGACTCTTTCCTCTTCCCCACGGTCCAGTCAGCGGGTTAATTAGGCCATCGGCCCTCGAGCCGAGAC
TTGTCTCTTATTTAGTTCTGGGGAGCGCCTCGTCGACATGAGTGATGTGGAGGAAAACAACTTCGAGGGCAGAGTTTTGGCTTGGTTTGA
AGAAGGTGAAGAAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGA
AAGAAATGCTGAAAATGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCG
GATTAAAGCTAAAGACATAGTTCCTGGTGATATTGTAGAAATTGCTGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGA
CCCACGAGCTGTCAACCAAGATAAAAAGAACATGCTGTTTTCTGGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAAC
TGGAGTTAACACCGAAATTGGCAAGATCCGGGATGAAATGGTGGCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATT
TGGGGAACAGCTTTCCAAAGTCATCTCCCTTATTTGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGG
GTCCTGGATCAGAGGTGCTATTTACTACTTTAAAATTGCAGTGGCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCAC
CACCTGCCTGGCTCTTGGAACTCGCAGAATGGCAAAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTC
TGTTATCTGCTCAGACAAGACTGGTACACTTACAACAAACCAGATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATAC
TTGTTCCCTTAATGAGTTTACCATAACTGGATCAACTTATGCACCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCA
GTATGATGGTCTGGTAGAATTAGCAACAATTTGTGCTCTTTGTAATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAA
AGTTGGAGAAGCTACAGAGACTGCTCTCACTTGCCTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGA
ACGTGCAAATGCCTGCAACTCAGTCATTAAACAGCTGATGAAAAAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGT
TTACTGTACACCAAATAAACCAAGCAGGACATCAATGAGCAAGATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCA
CATTCGAGTTGGAAGTACTAAGGTTCCTATGACCTCTGGAGTCAAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGA
CACACTGCGATGCCTGGCCCTGGCCACTCATGACAACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATA
TGAGACCAATCTGACCTTCGTTGGCTGCGTGGGCATGCTGGATCCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGC
AGGCATCCGGGTCATCATGATCACTGGGGACAACAAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGA
CGTGACGTCAAAAGCTTTCACAGGCCGGGAGTTTGATGAACTCAACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGC
TCGAGTTGAACCCTCCCACAAGTCTAAAATCGTAGAATTTCTTCAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGA
TGCTCCTGCTCTGAAGAAAGCCGAGATTGGCATTGCTATGGGCTCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGA
TGACAACTTCTCCACCATTGTGGCTGCCGTTGAGGAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTC
CAACGTCGGGGAAGTTGTCTGTATTTTCCTGACAGCAGCCCTTGGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCT
GGTGACAGATGGCCTGCCTGCCACTGCACTGGGGTTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACC
ATTGATCAGCGGGTGGCTCTTTTTCCGTTACTTGGCTATTGGCTGTTACGTCGGCGCTGCTACCGTGGGTGCTGCTGCATGGTGGTTCAT
TGCTGCTGACGGTGGTCCAAGAGTGTCCTTCTACCAGCTGAGTCATTTCCTACAGTGTAAAGAGGACAACCCGGACTTTGAAGGCGTGGA
TTGTGCAATCTTTGAATCCCCATACCCGATGACAATGGCGCTCTCTGTTCTAGTAACTATAGAAATGTGTAACGCCCTCAACAGCTTGTC
CGAAAACCAGTCCTTGCTGAGGATGCCCCCCTGGGAGAACATCTGGCTCGTGGGCTCCATCTGCCTGTCCATGTCACTCCACTTCCTGAT
CCTCTATGTCGAACCCTTGCCACTCATCTTCCAGATCACACCGCTGAACGTGACCCAGTGGCTGATGGTGCTGAAAATCTCCTTGCCCGT
GATTCTCATGGATGAGACGCTCAAGTTTGTGGCCCGCAACTACCTGGAACCTGGTAAAGAGTGTGTGCAGCCTGCCACCAAATCCTGCTC
GTTCTCGGCATGCACCGATGGGATTTCCTGGCCGTTTGTGCTGCTCATAATGCCCCTGGTGATCTGGGTCTATAGCACAGACACTAACTT
TAGCGATATGTTCTGGTCTTGACTGACAGTTTTCCATAAAGAAGATGTTTAACTTAATCAATTAATTTTTTTATTGTTTAAAGCAACTGT
CTATTTCTGCTGAATTTTCACATGAACATACTGGCTGGTGATGGAGGTTTCATACTCTAGATTTTGTTTTGCTTTTTCTGACTCCAGTGG
GGCAAGATTTTCCTTTTTTATACACATAATTAAAGTGTCCATTGACATGTACAGAGAACTAACACTATTTTATGCAAATATTTTTTTGTA
GATGAAAAAGCATGTACAGTGTTCTGTTTAATACTCATCCTTGTATAAAAAAAATAGTTGAGCCAGCAGACATTGTCAGCAAATTAATTG
GCAGCAGATTTTAGGAAATGAATGTGTGTGGTTTTTTTTCTAAAACTAAATAGCATGTATTGTGTCTTTTGCATGATGATCCGGATTTAA
TTTGATATCACAGTCTAATTTTTATTCATAAGCCAATTTTTCTGCACTGAGCAGAGTCTTGCTACCTCAGTCAGTATTGTTTTGGTTTGC
TACTTCCCTCACCCACTTTGGCCTCCGTTCACCCCACCCCACCCCACCTCTCCCCACCTTACCCCCGCCCCGCTTGGCTTCTTCTTTAGG
ATTGTGATGGTTCGTTCTGTTTACATCAGTTTTAACGAGAGGTATGCCTGTACTCGCTTGTGCAGAAAACATTGTTCCAGATTCAATCGA
CTGGGTTTATGTCCCTTCACATAGTTTTTAAGGTTATTTATTTAAATGTCTAATGTATTTTATTGTAACAGACATTGTTTTGCCAACATT
GCCTATTTCAGTGGCACGTCATCTAGTTTTAAAAAAATAAAACATTTTAAATGGACAGAGAAAAATAACTGTCTTGTCTTTAACTCGTAA
GTGGCTTACCTGGGACTAACAGACATGTCCAACTTTCTCTCCAGTTCTTAGCTCAGAACTTTAGTTGTACTCTGCTTGAGGGGAAGAAGG
CTCCTGCTCTGCTGTGTAGGTAGTCATAGGAATTGTATTCTTAATGTACAGGCACTAATTGTCATCTGTGATGTACATTTTATGCAAGTT
TCTGCTGGCCTGGTATAGAGAACATAAGGGCAAGTGTGTATGTGTGTGTATGTGTGTGTTTTGTAAAATCTGTAAATAGCACATGACCAA
ATGAACATATTGTATAGAACTATTTTTATTTGAATGTGGCACTAACCACCACCACCGTTACTACGATCAATGTTTGCGCATGTTCGAGAT
GAGTCTCACCAACAGTGTGTAAGTCATTAACAGTCCTAACTGTGGTGTTTTCCTCCAATGCCTTCCAACATCCATCAACTAACGTGAGTA
TTTTCTTCCTGGGATTTGGATGCTTTAGCCTAAAGGTGACTGCCACCAAGTGAGATAACTGTATGTCACTAACTTATAAGCCGCCTCCAT
GGCAGATGCTGCTGTGCTCCCTGATGCCCTGTGAGCACCGGGGTTGCCTGTGGCGCCTGCCATGTGACTCGGGCGCAGCATCAGCTGGCT
GGAGGTGTGGCTTTCATAGACCTCCACAGGCTGCCTAGGACAAGATGACCAGGAGGGCCCAAGCCAGACAAAAGCCGGAGTGGGGAGAGA
GGCATTTCAGCCAGACCAACAGGCTGAAGGAGCTGTGCAGACTATTGCTAAAATGAGGGTTCGCAGCTGCCAGGAGTCATCCCAGAACAT
TGCTACTTATTTATTAAAAAGCTAAAAACTAGTGAAAGCAAGTAACTGAACCAGTGAACTCTGGGTATCGATAGGTTCGTCTTAAATAGG
CCACTTCCCCACTCCCCCACCCCCCCTTGCTTGGTCTTGTCCTTGGTGGCTAAGACTTAGCTCTGCAGGGGATGTTAAAGCACAGTTAGT
AGGACGTGGCTCTGCACAGCCCAAAAACCAGCTTACTCCTTAGCCAGGGTGTGAGGCCTCGACTATATTCTTCAAAATGTACTTAGGCTC
TGGTTACTGGGATGGCCAGTAGATGTAATGCAGATGGTTGGAGTTTGGGGAGGGTTAGGAGGCATCAAGCAGGACAAGGTGCTGCTGAGT
TCAGAGGGCCCACGTTCAAGGGATGGAGGTGGAACCTGGAGACCGACTCTTAAAAGCACAGTCCGTGGTTGGGTGTGGTGGCTCATGCCT
GTAAGTAAGTCTCAGCCCTTTGGAGGCCACAGCAGAAGGATTGCTTGAGCCCAGGTACTCAAACCAGCCTGGGCAACAGAGTGAGGCCCT
GTCAAAAAAAAATCAGCCTTACTGTGAAGCCTCCAAGGCTGCTCGCAGGCAGCTGTGGCTCTCGGGAAGGGAGGCTGCTTTGCCCAGCAG
GGAACATTTGGGGCAGGGGGTAAATTTTGCCAGTTTGAGCATCATGAGGTGTAACAAGAAATGGGTTGAATGGGCCAAATGCAAGGAGTG
CATCTCTGGGCTGCAAACTGACTTGAGTGCTGCACTATTGCTATTCCGTGCAAACAAAACTCAGCTTTTCCTGACTCAGTTCCTTGACTT
AGTGGCCTTTACAAAAAAAGTTGAGTAGTGTGTGGCCTGCTGTCGCACAGCCCCTAGTTAGCTTCATGGTTTCTCAGCTTCAGACCCCTC
CAGCCCACAGAGGAGCCCATGGAGGGACCCACTTCCCTTGGTCCAGACAGCTGGGAGTGGGTTAGGCCCACTGCTGTTTTGAGCAGGGCC
ACTTGCTCCATTTCACTGAAGGCTTTGCTGGGTGAAAACACTTCAGCATCTCCTCCTCAGGTCAACCCATAAAGACCAGGTCCAGCACCG
TGGTCTTGGCACATCCCTGGCCTCAGGCCCTCACCTAACAGTGAGGCAGCAGCTGCCCAGCCCCGCAATGTGCCTGCTGTCAGGCAGCTC
TTGCCTGAAACTTACTTCCACATTCTTTCCTGATGGGCAGGTGGCTGAAGGCCCAGCCATCAGTGTCGCTTGTTGCCACCCCGTGCCTCC
CTTGGCCTCTCTGAGCTTTGCCCAGAAGACCAACAATCATACATACCCTAACTGGGACACCACTCTGCAGAATGCAGATGATCCATTCTG
GAGGAAGCTGTCCCTTGAGCTCAGTGAGCTCCCAGGCAAGCAGGGCATCTGGCCGACTTCCCTCACAACAGCTGCTCCCACATCCCCTCG
GACTGGAGCTTCAGCCCTGACTGAGGTGGGCAGACCTAAGACCTGAGACCACAAGATTAGCTCAGTGTCTACCAAGCATCTAGCCACTGT
CCAGGGCCAGAGCATACCACGTCTGCAGTGCCTGTGAGCAGAGCCAGCAGTTGCCCTGTGACTGTAACCACCAAATTGTCCAAACACCCG
CTGCAGTTAGCAAGAAGGGTAGGCTTCACCCTCCTTTACTGAGGAGAATGATGCGGAGGAGTTTCCTCTCCAGGGCTAGGCAAGGCAGGC
GAGCAGCCAGAAGCCGGGTGCCCACAGGGCAGGGACAGGAAGGCTGTGCTGCTACTGGCTGCTCACTTCTCCATCAACCTCACCCTCTGC
ACCACTAACCAAGACCTTGTCCTCTTGCCTGTCTCGCTGCTTTCACAGCTGCAACGATTGTGTCTGCCTCATGGGGTTTTCCTCCAGAGC
CTTTATTCTGTAGCCAGACGACACGAGGAGTCTGTGTCACTGAGCCAGTGCTTCTAGATGCTACCCTGTGTGGGCGGCACCTCAGGGACA
GTAAATCAGAAATGCTGGTCTTGAAACCTTGAAAAGATCAAGCTGAATGTTCCTTTTCATCTGTCGCTGTTGATCTTCATCTATTTAAAT
AGGTATTCTAACGTTTCCTCTCTGTATTTCATGAAGCTGATTTCCTCTCTCTTTCCTTTTCAGCAATACTGGAGTAACCGCTTCCTAAAC
CATTTTGCAGAAATGTAAGGGTGTTCGGTTGCGTGCATGTGCGTTTTTAGCAACACATCTACCAACCCTGTGCATGACTGATGTTGGGGA
AAAAGAAAAGTAAAAAACTTCCCAACTCACTTTGTGTTATGTGGAGGAAATGTGTATTACCAATGGGGTTGTTAGCTTTTAAATCAAAAT
ACTGATTACAGATGTACAATTTAGCTTAATCAGAAAGCCTCTCCAGAGAAGTTTGGTTTCTTTGCTGCAAGAGGAATGAGGCTCTGTAAC
CTTATCTAAGAACTTGGAAGCCGTCAGCCAAGTCGCCACATTTCTCTGCAAAATGTCATAGCTTATATAAATGTACAGTATTCAATTGTA
ATGCATGCCTTCGGTTGTAAGTAGCCAGATCCCTCTCCAGTGACATTGGAACATGCTACTTTTTAATTGGCCCTGTACAGTTTGCTTATT
TATAAATTCATTAAAAACACTACAGGTGTTGAATGGTTAAAATGTAGGCCTCCAGTTCATTTTCAGTTATTTTCTGAGTGTGCAGACAGC
TATTTCGCACTGTATTAAATGTAACTTATTTAATGAAATCAGAAGCAGTAGACAGATGTTGGTGCAATACAAATATTGTGATGCATTTAT
CTTAATAAAATGCTAAATGTCAATTTATCACTGCGCATGTTTGACTTTAGACTGTAAATAGAGATCAGTTTGTTTCTTTCTGTGCTGGTA

>93573_93573_2_TRA2A-ATP2A2_TRA2A_chr7_23571407_ENST00000297071_ATP2A2_chr12_110729824_ENST00000395494_length(amino acids)=954AA_BP=12
MSDVEENNFEGRVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIV
EIAGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLIC
IAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTT
NQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCL
VEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTS
GVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNK
GTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIA
MGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGF
NPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTM
ALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVAR

--------------------------------------------------------------
>93573_93573_3_TRA2A-ATP2A2_TRA2A_chr7_23571407_ENST00000297071_ATP2A2_chr12_110729824_ENST00000539276_length(transcript)=4019nt_BP=253nt
GCCCGCCCCCTTTACGTCGTGCTCTGAGGAGGCCAGGAGATTTCTGGCGGCGCCGGCGCCATTTTGCTGGAGCCTGCGACCGAGTGGGAG
TGGAGTGGAGCGGCTGTGGTTGCCGACTCTTTCCTCTTCCCCACGGTCCAGTCAGCGGGTTAATTAGGCCATCGGCCCTCGAGCCGAGAC
TTGTCTCTTATTTAGTTCTGGGGAGCGCCTCGTCGACATGAGTGATGTGGAGGAAAACAACTTCGAGGGCAGAGTTTTGGCTTGGTTTGA
AGAAGGTGAAGAAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGA
AAGAAATGCTGAAAATGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCG
GATTAAAGCTAAAGACATAGTTCCTGGTGATATTGTAGAAATTGCTGTTGGTGACAAAGTTCCTGCTGATATAAGGTTAACTTCCATCAA
ATCTACCACACTAAGAGTTGACCAGTCAATTCTCACAGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGACCCACGAGC
TGTCAACCAAGATAAAAAGAACATGCTGTTTTCTGGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAACTGGAGTTAA
CACCGAAATTGGCAAGATCCGGGATGAAATGGTGGCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATTTGGGGAACA
GCTTTCCAAAGTCATCTCCCTTATTTGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGGGTCCTGGAT
CAGAGGTGCTATTTACTACTTTAAAATTGCAGTGGCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCACCACCTGCCT
GGCTCTTGGAACTCGCAGAATGGCAAAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTCTGTTATCTG
CTCAGACAAGACTGGTACACTTACAACAAACCAGATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATACTTGTTCCCT
TAATGAGTTTACCATAACTGGATCAACTTATGCACCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCAGTATGATGG
TCTGGTAGAATTAGCAACAATTTGTGCTCTTTGTAATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAAAGTTGGAGA
AGCTACAGAGACTGCTCTCACTTGCCTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGAACGTGCAAA
TGCCTGCAACTCAGTCATTAAACAGCTGATGAAAAAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGTTTACTGTAC
ACCAAATAAACCAAGCAGGACATCAATGAGCAAGATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCACATTCGAGT
TGGAAGTACTAAGGTTCCTATGACCTCTGGAGTCAAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGACACACTGCG
ATGCCTGGCCCTGGCCACTCATGACAACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATATGAGACCAA
TCTGACCTTCGTTGGCTGCGTGGGCATGCTGGATCCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGCAGGCATCCG
GGTCATCATGATCACTGGGGACAACAAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGACGTGACGTC
AAAAGCTTTCACAGGCCGGGAGTTTGATGAACTCAACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGCTCGAGTTGA
ACCCTCCCACAAGTCTAAAATCGTAGAATTTCTTCAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGATGCTCCTGC
TCTGAAGAAAGCCGAGATTGGCATTGCTATGGGCTCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGATGACAACTT
CTCCACCATTGTGGCTGCCGTTGAGGAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTCCAACGTCGG
GGAAGTTGTCTGTATTTTCCTGACAGCAGCCCTTGGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCTGGTGACAGA
TGGCCTGCCTGCCACTGCACTGGGGTTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACCATTGATCAG
CGGGTGGCTCTTTTTCCGTTACTTGGCTATTGGCTGTTACGTCGGCGCTGCTACCGTGGGTGCTGCTGCATGGTGGTTCATTGCTGCTGA
CGGTGGTCCAAGAGTGTCCTTCTACCAGCTGAGTCATTTCCTACAGTGTAAAGAGGACAACCCGGACTTTGAAGGCGTGGATTGTGCAAT
CTTTGAATCCCCATACCCGATGACAATGGCGCTCTCTGTTCTAGTAACTATAGAAATGTGTAACGCCCTCAACAGCTTGTCCGAAAACCA
GTCCTTGCTGAGGATGCCCCCCTGGGAGAACATCTGGCTCGTGGGCTCCATCTGCCTGTCCATGTCACTCCACTTCCTGATCCTCTATGT
CGAACCCTTGCCACTCATCTTCCAGATCACACCGCTGAACGTGACCCAGTGGCTGATGGTGCTGAAAATCTCCTTGCCCGTGATTCTCAT
GGATGAGACGCTCAAGTTTGTGGCCCGCAACTACCTGGAACCTGGTAAAGAGTGTGTGCAGCCTGCCACCAAATCCTGCTCGTTCTCGGC
ATGCACCGATGGGATTTCCTGGCCGTTTGTGCTGCTCATAATGCCCCTGGTGATCTGGGTCTATAGCACAGACACTAACTTTAGCGATAT
GTTCTGGTCTTGACTGACAGTTTTCCATAAAGAAGATGTTTAACTTAATCAATTAATTTTTTTATTGTTTAAAGCAACTGTCTATTTCTG
CTGAATTTTCACATGAACATACTGGCTGGTGATGGAGGTTTCATACTCTAGATTTTGTTTTGCTTTTTCTGACTCCAGTGGGGCAAGATT
TTCCTTTTTTATACACATAATTAAAGTGTCCATTGACATGTACAGAGAACTAACACTATTTTATGCAAATATTTTTTTGTAGATGAAAAA
GCATGTACAGTGTTCTGTTTAATACTCATCCTTGTATAAAAAAAATAGTTGAGCCAGCAGACATTGTCAGCAAATTAATTGGCAGCAGAT
TTTAGGAAATGAATGTGTGTGGTTTTTTTTCTAAAACTAAATAGCATGTATTGTGTCTTTTGCATGATGATCCGGATTTAATTTGATATC
ACAGTCTAATTTTTATTCATAAGCCAATTTTTCTGCACTGAGCAGAGTCTTGCTACCTCAGTCAGTATTGTTTTGGTTTGCTACTTCCCT
CACCCACTTTGGCCTCCGTTCACCCCACCCCACCCCACCTCTCCCCACCTTACCCCCGCCCCGCTTGGCTTCTTCTTTAGGATTGTGATG
GTTCGTTCTGTTTACATCAGTTTTAACGAGAGGTATGCCTGTACTCGCTTGTGCAGAAAACATTGTTCCAGATTCAATCGACTGGGTTTA
TGTCCCTTCACATAGTTTTTAAGGTTATTTATTTAAATGTCTAATGTATTTTATTGTAACAGACATTGTTTTGCCAACATTGCCTATTTC

>93573_93573_3_TRA2A-ATP2A2_TRA2A_chr7_23571407_ENST00000297071_ATP2A2_chr12_110729824_ENST00000539276_length(amino acids)=981AA_BP=12
MSDVEENNFEGRVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIV
EIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVA
TEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNA
IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCN
DSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKM
FVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDP
PRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQ
SFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALG
FPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSH
FLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPL

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Fusion Gene PPI Analysis for TRA2A-ATP2A2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000308664		2	21	575_594	73.0	998.0	HAX1
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000395494		2	19	575_594	73.0	1016.0	HAX1
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000539276		2	20	575_594	73.0	1043.0	HAX1
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000308664		2	21	787_807	73.0	998.0	PLN
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000308664		2	21	931_942	73.0	998.0	PLN
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000395494		2	19	787_807	73.0	1016.0	PLN
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000395494		2	19	931_942	73.0	1016.0	PLN
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000539276		2	20	787_807	73.0	1043.0	PLN
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000539276		2	20	931_942	73.0	1043.0	PLN
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000308664		2	21	788_1042	73.0	998.0	TMEM64 and PDIA3
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000395494		2	19	788_1042	73.0	1016.0	TMEM64 and PDIA3
Tgene	ATP2A2	chr7:23571407	chr12:110729824	ENST00000539276		2	20	788_1042	73.0	1043.0	TMEM64 and PDIA3

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TRA2A-ATP2A2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TRA2A-ATP2A2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source