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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BCL2L13-MICAL3 (FusionGDB2 ID:9358)

Fusion Gene Summary for BCL2L13-MICAL3

Fusion gene summary

Fusion gene information	Fusion gene name: BCL2L13-MICAL3
	Fusion gene ID: 9358
		Hgene	Tgene
	Gene symbol	BCL2L13	MICAL3
	Gene ID	23786	57553
	Gene name	BCL2 like 13	microtubule associated monooxygenase, calponin and LIM domain containing 3
	Synonyms	BCL-RAMBO\|Bcl2-L-13\|MIL1	MICAL-3
	Cytomap	22q11.21	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	bcl-2-like protein 13BCL2-like 13 (apoptosis facilitator)	[F-actin]-monooxygenase MICAL3[F-actin]-methionine sulfoxide oxidase MICAL3flavoprotein oxidoreductase MICAL3molecule interacting with CasL protein 3protein MICAL-3protein-methionine sulfoxide oxidase MICAL3
	Modification date	20200313	20200313
	UniProtAcc	Q9BXK5	Q7RTP6
	Ensembl transtripts involved in fusion gene	ENST00000317582, ENST00000337612, ENST00000355028, ENST00000399782, ENST00000418951, ENST00000485631, ENST00000493680, ENST00000538149, ENST00000543133,	ENST00000207726, ENST00000383094, ENST00000400561, ENST00000414725, ENST00000429452, ENST00000441493, ENST00000444520, ENST00000580469, ENST00000585038,
Fusion gene scores	* DoF score	17 X 18 X 10=3060	13 X 13 X 4=676
	# samples	23	14
	** MAII score	log2(23/3060*10)=-3.73382588663564 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/676*10)=-2.27159641933722 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BCL2L13 [Title/Abstract] AND MICAL3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BCL2L13(18151828)-MICAL3(18459602), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MICAL3	GO:0007010	cytoskeleton organization	24440334
Tgene	MICAL3	GO:0030042	actin filament depolymerization	24440334

Fusion gene breakpoints across BCL2L13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MICAL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	EC525261	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+

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Fusion Gene ORF analysis for BCL2L13-MICAL3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000317582	ENST00000207726	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000317582	ENST00000383094	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000317582	ENST00000400561	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000317582	ENST00000414725	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000317582	ENST00000429452	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000317582	ENST00000441493	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000317582	ENST00000444520	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000317582	ENST00000580469	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000317582	ENST00000585038	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000337612	ENST00000207726	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000337612	ENST00000383094	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000337612	ENST00000400561	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000337612	ENST00000414725	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000337612	ENST00000429452	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000337612	ENST00000441493	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000337612	ENST00000444520	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000337612	ENST00000580469	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000337612	ENST00000585038	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000355028	ENST00000207726	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000355028	ENST00000383094	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000355028	ENST00000400561	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000355028	ENST00000414725	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000355028	ENST00000429452	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000355028	ENST00000441493	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000355028	ENST00000444520	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000355028	ENST00000580469	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000355028	ENST00000585038	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000399782	ENST00000207726	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000399782	ENST00000383094	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000399782	ENST00000400561	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000399782	ENST00000414725	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000399782	ENST00000429452	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000399782	ENST00000441493	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000399782	ENST00000444520	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000399782	ENST00000580469	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000399782	ENST00000585038	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000418951	ENST00000207726	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000418951	ENST00000383094	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000418951	ENST00000400561	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000418951	ENST00000414725	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000418951	ENST00000429452	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000418951	ENST00000441493	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000418951	ENST00000444520	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000418951	ENST00000580469	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000418951	ENST00000585038	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000485631	ENST00000207726	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000485631	ENST00000383094	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000485631	ENST00000400561	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000485631	ENST00000414725	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000485631	ENST00000429452	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000485631	ENST00000441493	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000485631	ENST00000444520	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000485631	ENST00000580469	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000485631	ENST00000585038	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000493680	ENST00000207726	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000493680	ENST00000383094	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000493680	ENST00000400561	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000493680	ENST00000414725	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000493680	ENST00000429452	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000493680	ENST00000441493	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000493680	ENST00000444520	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000493680	ENST00000580469	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000493680	ENST00000585038	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000538149	ENST00000207726	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000538149	ENST00000383094	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000538149	ENST00000400561	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000538149	ENST00000414725	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000538149	ENST00000429452	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000538149	ENST00000441493	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000538149	ENST00000444520	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000538149	ENST00000580469	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000538149	ENST00000585038	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000543133	ENST00000207726	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000543133	ENST00000383094	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000543133	ENST00000400561	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000543133	ENST00000414725	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000543133	ENST00000429452	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000543133	ENST00000441493	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000543133	ENST00000444520	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000543133	ENST00000580469	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+
intron-intron	ENST00000543133	ENST00000585038	BCL2L13	chr22	18151828	+	MICAL3	chr22	18459602	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for BCL2L13-MICAL3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BCL2L13-MICAL3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:18151828/:18459602)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BCL2L13 Q9BXK5	MICAL3 Q7RTP6
FUNCTION: May promote the activation of caspase-3 and apoptosis.	FUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269\|PubMed:21596566, ECO:0000269\|PubMed:24440334}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for BCL2L13-MICAL3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BCL2L13-MICAL3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for BCL2L13-MICAL3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for BCL2L13-MICAL3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source