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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TRABD2B-PKN2 (FusionGDB2 ID:93619)

Fusion Gene Summary for TRABD2B-PKN2

Fusion gene summary

Fusion gene information	Fusion gene name: TRABD2B-PKN2
	Fusion gene ID: 93619
		Hgene	Tgene
	Gene symbol	TRABD2B	PKN2
	Gene ID	388630	5586
	Gene name	TraB domain containing 2B	protein kinase N2
	Synonyms	TIKI2	PAK2\|PRK2\|PRKCL2\|PRO2042\|Pak-2\|STK7
	Cytomap	1p33	1p22.2
	Type of gene	protein-coding	protein-coding
	Description	metalloprotease TIKI2TRAB domain-containing protein 2BUPF0632 protein Aheart, kidney and adipose-enriched transmembrane protein homolog	serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000606738, ENST00000435576,	ENST00000370505, ENST00000370513, ENST00000495119, ENST00000544045, ENST00000316005, ENST00000370521,
Fusion gene scores	* DoF score	8 X 3 X 6=144	5 X 3 X 3=45
	# samples	8	4
	** MAII score	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TRABD2B [Title/Abstract] AND PKN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TRABD2B(48459706)-PKN2(89206671), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TRABD2B	GO:0006508	proteolysis	22726442
Hgene	TRABD2B	GO:0030178	negative regulation of Wnt signaling pathway	22726442
Hgene	TRABD2B	GO:0031334	positive regulation of protein complex assembly	22726442
Hgene	TRABD2B	GO:1904808	positive regulation of protein oxidation	22726442
Tgene	PKN2	GO:0006468	protein phosphorylation	17332740
Tgene	PKN2	GO:0010631	epithelial cell migration	21754995

Fusion gene breakpoints across TRABD2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PKN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A7-A5ZV-01A	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+

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Fusion Gene ORF analysis for TRABD2B-PKN2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000606738	ENST00000370505	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
5CDS-intron	ENST00000606738	ENST00000370513	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
5CDS-intron	ENST00000606738	ENST00000495119	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
5CDS-intron	ENST00000606738	ENST00000544045	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
5UTR-3CDS	ENST00000435576	ENST00000316005	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
5UTR-3CDS	ENST00000435576	ENST00000370521	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
5UTR-intron	ENST00000435576	ENST00000370505	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
5UTR-intron	ENST00000435576	ENST00000370513	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
5UTR-intron	ENST00000435576	ENST00000495119	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
5UTR-intron	ENST00000435576	ENST00000544045	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
In-frame	ENST00000606738	ENST00000316005	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+
In-frame	ENST00000606738	ENST00000370521	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000606738

TRABD2B

chr1

48459706

ENST00000316005

PKN2

chr1

89206671

2997

772

2538

827

ENST00000606738

TRABD2B

chr1

48459706

ENST00000370521

PKN2

chr1

89206671

6486

772

3678

1207

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000606738	ENST00000316005	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+	0.001564042	0.9984359
ENST00000606738	ENST00000370521	TRABD2B	chr1	48459706	-	PKN2	chr1	89206671	+	5.33E-05	0.9999467

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Fusion Genomic Features for TRABD2B-PKN2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TRABD2B	chr1	48459705	-	PKN2	chr1	89206670	+	3.94E-07	0.99999964
TRABD2B	chr1	48459705	-	PKN2	chr1	89206670	+	3.94E-07	0.99999964

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRABD2B-PKN2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:48459706/chr1:89206671)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370505

121_203

828.0

Domain

REM-1 2

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370505

204_284

828.0

Domain

REM-1 3

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370505

33_109

828.0

Domain

REM-1 1

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370505

353_473

828.0

Domain

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370505

657_916

828.0

Domain

Protein kinase

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370505

917_984

828.0

Domain

AGC-kinase C-terminal

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370513

121_203

937.0

Domain

REM-1 2

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370513

204_284

937.0

Domain

REM-1 3

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370513

33_109

937.0

Domain

REM-1 1

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370513

353_473

937.0

Domain

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370513

657_916

937.0

Domain

Protein kinase

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370513

917_984

937.0

Domain

AGC-kinase C-terminal

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370521

121_203

985.0

Domain

REM-1 2

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370521

204_284

985.0

Domain

REM-1 3

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370521

33_109

985.0

Domain

REM-1 1

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370521

353_473

985.0

Domain

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370521

657_916

985.0

Domain

Protein kinase

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370521

917_984

985.0

Domain

AGC-kinase C-terminal

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000544045

121_203

659.0

Domain

REM-1 2

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000544045

204_284

659.0

Domain

REM-1 3

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000544045

33_109

659.0

Domain

REM-1 1

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000544045

353_473

659.0

Domain

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000544045

657_916

659.0

Domain

Protein kinase

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000544045

917_984

659.0

Domain

AGC-kinase C-terminal

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370505

663_671

828.0

Nucleotide binding

ATP

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370513

663_671

937.0

Nucleotide binding

ATP

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370521

663_671

985.0

Nucleotide binding

ATP

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000544045

663_671

659.0

Nucleotide binding

ATP

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370505

382_463

828.0

Region

Necessary to rescue apical junction formation

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370505

917_977

828.0

Region

Note=Necessary for the catalytic activity

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370505

978_984

828.0

Region

Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370513

382_463

937.0

Region

Necessary to rescue apical junction formation

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370513

917_977

937.0

Region

Note=Necessary for the catalytic activity

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370513

978_984

937.0

Region

Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370521

382_463

985.0

Region

Necessary to rescue apical junction formation

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370521

917_977

985.0

Region

Note=Necessary for the catalytic activity

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000370521

978_984

985.0

Region

Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000544045

382_463

659.0

Region

Necessary to rescue apical junction formation

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000544045

917_977

659.0

Region

Note=Necessary for the catalytic activity

Tgene

PKN2

chr1:48459706

chr1:89206671

ENST00000544045

978_984

659.0

Region

Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TRABD2B

chr1:48459706

chr1:89206671

ENST00000606738

20_494

222

518.0

Topological domain

Extracellular

Hgene

TRABD2B

chr1:48459706

chr1:89206671

ENST00000606738

516_517

222

518.0

Topological domain

Cytoplasmic

Hgene

TRABD2B

chr1:48459706

chr1:89206671

ENST00000606738

495_515

222

518.0

Transmembrane

Helical

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Fusion Gene Sequence for TRABD2B-PKN2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>93619_93619_1_TRABD2B-PKN2_TRABD2B_chr1_48459706_ENST00000606738_PKN2_chr1_89206671_ENST00000316005_length(transcript)=2997nt_BP=772nt
TGGAGCCCCGTGCTCCAGAGGAAACTCCGTGCCCAACTGGGGGCTCCCCGCCCCGCTGAGGGGCGCCGCCCAGGAGGGTCCCCCGCGCCC
CGCGGGCCCTGGCAGGATGCACGCCGCCCTGGCGGGGCCGCTGCTCGCCGCCCTCCTCGCCACCGCTCGCGCCCGCCCGCAGCCCCCGGA
CGGAGGACAGTGCCGGCCGCCCGGATCGCAGAGGGACTTGAACTCCTTCCTGTGGACGATTCGGCGTGATCCTCCGGCCTACCTGTTTGG
CACTATTCACGTCCCCTACACCCGCGTCTGGGACTTCATCCCGGACAACTCCAAGGCAGCCTTCCAGGCTAGCACCCGTGTCTACTTTGA
GCTGGACCTTACAGACCCCTACACCATCTCGGCCCTGGCCAGCTGCCAGCTGCTGCCGCACGGGGAAAACCTGCAGGACGTGCTGCCCCA
CGAGCTTTACTGGCGCTTGAAGCGCCACCTGGACTACGTGAAGTTGATGATGCCCTCCTGGATGACGCCCGCTCAGCGGGGCAAGGGGCT
CTATGCTGACTACCTATTCAATGCCATCGCGGGCAACTGGGAGCGCAAGAGGCCCGTCTGGGTGATGCTCATGGTAAACTCGCTCACAGA
GAGGGACGTGCGCTTCCGTGGTGTGCCCGTGCTCGACCTCTACCTGGCCCAGCAGGCTGAGAAGATGAAGAAGACCACAGGGGCTGTGGA
GCAGGTGGAGGAGCAGTGCCATCCCCTCAACAACGGGCTCAACTTCTCCCAGGGGGATTCCCGAAGTCTTCCGTTTTCTGAGAATGTGAG
TGCTGTTCAAAAATTAGACTTTTCAGATACAATGGTGCAGCAGAAATTGGATGATATCAAGGATCGAATTAAGAGAGAAATAAGGAAAGA
ACTGAAAATCAAAGAAGGAGCTGAAAATCTGAGGAAAGTCACAACAGATAAAAAAAGTTTGGCTTATGTAGACAACATTTTGAAAAAATC
AAATAAAAAATTAGAAGAACTACATCACAAGCTGCAGGAATTAAATGCACATATTGTTGTATCAGATCCAGAAGATATTACAGATTGCCC
AAGGACTCCAGATACTCCAAATAATGACCCTCGTTGTTCTACTAGCAACAATAGATTGAAGGCCTTACAAAAACAATTGGATATAGAACT
TAAAGTAAAACAAGGTGCAGAGAATATGATACAGATGTATTCAAATGGATCTTCAAAGGATCGGAAACTCCATGGTACAGCTCAGCAACT
GCTCCAGGACAGCAAGACAAAAATAGAAGTCATACGAATGCAGATTCTTCAGGCAGTCCAGACTAATGAATTGGCTTTTGATAATGCAAA
ACCTGTGATAAGTCCTCTTGAACTTCGGATGGAAGAATTAAGGCATCATTTTAGGATAGAGTTTGCAGTAGCAGAAGGTGCAAAGAATGT
AATGAAATTACTTGGCTCAGGAAAAGTAACAGACAGAAAAGCACTTTCAGAAGCTCAAGCAAGATTTAATGAATCAAGTCAGAAGTTGGA
CCTTTTAAAGTATTCATTAGAGCAAAGATTAAACGAAGTCCCCAAGAATCATCCCAAAAGCAGGATTATTATTGAAGAACTTTCACTTGT
TGCTGCATCACCAACACTAAGTCCACGTCAAAGTATGATATCTACGCAAAATCAATATAGTACACTATCCAAACCAGCAGCACTAACAGG
TACTTTGGAAGTTCGTCTTATGGGCTGCCAAGATATCCTAGAGAATGTCCCTGGACGGTCAAAAGCAACATCAGTTGCACTGCCTGGTTG
GAGTCCAAGTGAAACCAGATCATCTTTCATGAGCAGAACGAGTAAAAGTAAAAGCGGAAGTAGTCGAAATCTTCTAAAAACCGATGACTT
GTCCAATGATGTCTGTGCTGTTTTGAAGCTCGATAATACTGTGGTTGGCCAAACTAGCTGGAAACCCATTTCCAATCAGTCATGGGACCA
GAAGTTTACACTGGAACTGGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGGCGTGATTGGCGGTCTCTGTGTGCTGTAAAATTTCT
GAGGTTAGAAGATTTTTTAGACAACCAACGGCATGGCATGTGTCTCTATTTGGAACCACAGGGTACTTTATTTGCAGAGGTTACCTTTTT
TAATCCAGTTATTGAAAGAAGACCAAAACTTCAAAGACAAAAGAAAATTTTTTCAAAGCAACAAGGCAAAACATTTCTCAGAGCTCCTCA
AATGAATATTAATATTGCCACTTGGGGAAGGCTAGTAAGAAGAGCTATTCCTACAGTAAATCATTCTGGCACCTTCAGCCCTCAAGCTCC
TGTGCCTACTACAGTGCCAGTGGTTGATGTACGCATCCCTCAACTAGCACCTCCAGCTAGGTATGTGTCTGAGATTTTAAGCATCTCTTA
TACAAAGTTATTGGGACATTCTTACGTACTGATTATAGCAGGTGTACTGAGTCTTGCTTTTTTCCCAAGTAGTATTTTGAAAGTAGTGTT
CTGTTTACTTAAAAAGTAAATTGTTTGCTTTAATTTTAAAGCTGTTTAAAATACAGACTTTCTATTACTGTTTTGGTGAGTTACTTTATC
TTCTATAAGTGATTCTACAGTAACCAAATTGGACTTTGATCTTGAGCCTGAACCTCCTCCAGCCCCACCACGAGCTTCTTCTCTTGGAGA
AATAGATGAATCTTCTGAATTAAGAGTTTTGGATATACCAGGACAGGCAAGCCATTTTAAACCTTGCATAATTCCTCTTCACTGAATGAA
TTAGCAATAAAAGCATCATAGTGAATAAGGCGTGTCTTTCCATTTAAAATTGCCACTGAACTGTGAATTTATGGTTTTTTGTTTGTTTTT
TGTTTTTGTTTTTGTTTTTTGAGACAGAGTTTCACTCTTGTTACCCAGGCTGGAGTGCAATGGCATGATCTCGGCTCACTGCAACCTCCG

>93619_93619_1_TRABD2B-PKN2_TRABD2B_chr1_48459706_ENST00000606738_PKN2_chr1_89206671_ENST00000316005_length(amino acids)=827AA_BP=234
MRGAAQEGPPRPAGPGRMHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWTIRRDPPAYLFGTIHVPYTRVWDFIPDNSK
AAFQASTRVYFELDLTDPYTISALASCQLLPHGENLQDVLPHELYWRLKRHLDYVKLMMPSWMTPAQRGKGLYADYLFNAIAGNWERKRP
VWVMLMVNSLTERDVRFRGVPVLDLYLAQQAEKMKKTTGAVEQVEEQCHPLNNGLNFSQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDD
IKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNR
LKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFR
IEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQ
YSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQT
SWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFS
KQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPARYVSEILSISYTKLLGHSYVLIIAGVLSL

--------------------------------------------------------------
>93619_93619_2_TRABD2B-PKN2_TRABD2B_chr1_48459706_ENST00000606738_PKN2_chr1_89206671_ENST00000370521_length(transcript)=6486nt_BP=772nt
TGGAGCCCCGTGCTCCAGAGGAAACTCCGTGCCCAACTGGGGGCTCCCCGCCCCGCTGAGGGGCGCCGCCCAGGAGGGTCCCCCGCGCCC
CGCGGGCCCTGGCAGGATGCACGCCGCCCTGGCGGGGCCGCTGCTCGCCGCCCTCCTCGCCACCGCTCGCGCCCGCCCGCAGCCCCCGGA
CGGAGGACAGTGCCGGCCGCCCGGATCGCAGAGGGACTTGAACTCCTTCCTGTGGACGATTCGGCGTGATCCTCCGGCCTACCTGTTTGG
CACTATTCACGTCCCCTACACCCGCGTCTGGGACTTCATCCCGGACAACTCCAAGGCAGCCTTCCAGGCTAGCACCCGTGTCTACTTTGA
GCTGGACCTTACAGACCCCTACACCATCTCGGCCCTGGCCAGCTGCCAGCTGCTGCCGCACGGGGAAAACCTGCAGGACGTGCTGCCCCA
CGAGCTTTACTGGCGCTTGAAGCGCCACCTGGACTACGTGAAGTTGATGATGCCCTCCTGGATGACGCCCGCTCAGCGGGGCAAGGGGCT
CTATGCTGACTACCTATTCAATGCCATCGCGGGCAACTGGGAGCGCAAGAGGCCCGTCTGGGTGATGCTCATGGTAAACTCGCTCACAGA
GAGGGACGTGCGCTTCCGTGGTGTGCCCGTGCTCGACCTCTACCTGGCCCAGCAGGCTGAGAAGATGAAGAAGACCACAGGGGCTGTGGA
GCAGGTGGAGGAGCAGTGCCATCCCCTCAACAACGGGCTCAACTTCTCCCAGGGGGATTCCCGAAGTCTTCCGTTTTCTGAGAATGTGAG
TGCTGTTCAAAAATTAGACTTTTCAGATACAATGGTGCAGCAGAAATTGGATGATATCAAGGATCGAATTAAGAGAGAAATAAGGAAAGA
ACTGAAAATCAAAGAAGGAGCTGAAAATCTGAGGAAAGTCACAACAGATAAAAAAAGTTTGGCTTATGTAGACAACATTTTGAAAAAATC
AAATAAAAAATTAGAAGAACTACATCACAAGCTGCAGGAATTAAATGCACATATTGTTGTATCAGATCCAGAAGATATTACAGATTGCCC
AAGGACTCCAGATACTCCAAATAATGACCCTCGTTGTTCTACTAGCAACAATAGATTGAAGGCCTTACAAAAACAATTGGATATAGAACT
TAAAGTAAAACAAGGTGCAGAGAATATGATACAGATGTATTCAAATGGATCTTCAAAGGATCGGAAACTCCATGGTACAGCTCAGCAACT
GCTCCAGGACAGCAAGACAAAAATAGAAGTCATACGAATGCAGATTCTTCAGGCAGTCCAGACTAATGAATTGGCTTTTGATAATGCAAA
ACCTGTGATAAGTCCTCTTGAACTTCGGATGGAAGAATTAAGGCATCATTTTAGGATAGAGTTTGCAGTAGCAGAAGGTGCAAAGAATGT
AATGAAATTACTTGGCTCAGGAAAAGTAACAGACAGAAAAGCACTTTCAGAAGCTCAAGCAAGATTTAATGAATCAAGTCAGAAGTTGGA
CCTTTTAAAGTATTCATTAGAGCAAAGATTAAACGAAGTCCCCAAGAATCATCCCAAAAGCAGGATTATTATTGAAGAACTTTCACTTGT
TGCTGCATCACCAACACTAAGTCCACGTCAAAGTATGATATCTACGCAAAATCAATATAGTACACTATCCAAACCAGCAGCACTAACAGG
TACTTTGGAAGTTCGTCTTATGGGCTGCCAAGATATCCTAGAGAATGTCCCTGGACGGTCAAAAGCAACATCAGTTGCACTGCCTGGTTG
GAGTCCAAGTGAAACCAGATCATCTTTCATGAGCAGAACGAGTAAAAGTAAAAGCGGAAGTAGTCGAAATCTTCTAAAAACCGATGACTT
GTCCAATGATGTCTGTGCTGTTTTGAAGCTCGATAATACTGTGGTTGGCCAAACTAGCTGGAAACCCATTTCCAATCAGTCATGGGACCA
GAAGTTTACACTGGAACTGGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGGCGTGATTGGCGGTCTCTGTGTGCTGTAAAATTTCT
GAGGTTAGAAGATTTTTTAGACAACCAACGGCATGGCATGTGTCTCTATTTGGAACCACAGGGTACTTTATTTGCAGAGGTTACCTTTTT
TAATCCAGTTATTGAAAGAAGACCAAAACTTCAAAGACAAAAGAAAATTTTTTCAAAGCAACAAGGCAAAACATTTCTCAGAGCTCCTCA
AATGAATATTAATATTGCCACTTGGGGAAGGCTAGTAAGAAGAGCTATTCCTACAGTAAATCATTCTGGCACCTTCAGCCCTCAAGCTCC
TGTGCCTACTACAGTGCCAGTGGTTGATGTACGCATCCCTCAACTAGCACCTCCAGCTAGTGATTCTACAGTAACCAAATTGGACTTTGA
TCTTGAGCCTGAACCTCCTCCAGCCCCACCACGAGCTTCTTCTCTTGGAGAAATAGATGAATCTTCTGAATTAAGAGTTTTGGATATACC
AGGACAGGATTCAGAGACTGTTTTTGATATTCAGAATGACAGAAATAGTATACTTCCAAAATCTCAATCTGAATACAAGCCTGATACTCC
TCAGTCAGGCCTAGAATATAGTGGTATTCAAGAACTTGAGGACAGAAGATCTCAGCAAAGGTTTCAGTTTAATCTACAAGATTTCAGGTG
TTGTGCTGTCTTGGGAAGAGGACATTTTGGAAAGGTGCTTTTAGCTGAATATAAAAACACAAATGAGATGTTTGCTATAAAAGCCTTAAA
GAAAGGAGATATTGTGGCTCGAGATGAAGTAGACAGCCTGATGTGTGAAAAAAGAATTTTTGAAACTGTGAATAGTGTAAGGCATCCCTT
TTTGGTGAACCTTTTTGCATGTTTCCAAACCAAAGAGCATGTTTGCTTTGTAATGGAATATGCTGCCGGTGGGGACCTAATGATGCACAT
TCATACTGATGTCTTTTCTGAACCAAGAGCTGTATTTTATGCTGCTTGTGTAGTTCTTGGGTTGCAGTATTTACATGAACACAAAATTGT
TTATAGAGATTTGAAATTGGATAACTTATTGCTAGATACAGAGGGCTTTGTGAAAATTGCTGATTTTGGTCTTTGCAAAGAAGGAATGGG
ATATGGAGATAGAACAAGCACATTTTGTGGCACTCCTGAATTTCTTGCCCCAGAAGTATTAACAGAAACTTCTTATACAAGGGCTGTAGA
TTGGTGGGGCCTTGGCGTGCTTATATATGAAATGCTTGTTGGTGAGTCTCCCTTTCCTGGTGATGATGAAGAGGAAGTTTTTGACAGTAT
TGTAAATGATGAAGTAAGGTATCCAAGGTTCTTATCTACAGAAGCCATTTCTATAATGAGAAGGCTGTTAAGAAGAAATCCTGAACGGCG
CCTTGGGGCTAGCGAGAAAGATGCAGAGGATGTAAAAAAGCACCCATTTTTCCGGCTAATTGATTGGAGCGCTCTGATGGACAAAAAAGT
AAAGCCACCATTTATACCTACCATAAGAGGACGAGAAGATGTTAGTAATTTTGATGATGAATTTACCTCAGAAGCACCTATTCTGACTCC
ACCTCGAGAACCAAGGATACTTTCGGAAGAGGAGCAGGAAATGTTCAGAGATTTTGACTACATTGCTGATTGGTGTTAAGTTGCTAGACA
CTGCGAAACCAAGCTGACTCACAAGAAGACCTCTTAAAAATAGCAACCCTTCATTTGCTCTCTGTGCCACCAATAGCTTCTGAGTTTTTT
GTTGTTGTTGTTTTTATTGAAACACGTGAAGATTTGTTTAAAAGTACCATTCTAATACTTCTTCAAAAGTGGCTCCTCATTGTACTTCAG
CGTAAATATGAGCACTGGAAACAGTTTCATGGAGTTTAAGTTGAGTGAACATCGGCCATGAAAATCCATCACGAATACTTTTGGATCAAT
AGTCTATTTTTAAAAAGAAAGAAAAAAACCACTTTTTTATAGTCCCTAGCTTTGCCATATGCCCGCCTTAAGTGGAAGGAAAGTTAATCA
CTTAACTATGTTTTATAAAAAGAAAAAAGGGCTTGGAATGCTATTACTGTTCACACAAAGTATGATTCTGTTTGAATAAGGCAAATGCTC
CTTTTTTTAAAAAAAAAGACATTACTGTAATATCAAAAACCGTGGCAGTTTGTATACAACTCGGGGCTTGATTTTTTTTAAAAAAACAGA
ATGAATTGATGTCTTATTTTATAAATGTTCTATATTTATTAGGAGAAAACTTTATATTGCCTTTTTTATCAATCATGTAACAGGCTTATA
GCTTTCCAACAGAGCTGCTTGCCAAACAATTTTTTTTGTTTATTAAACAGTGCTGAAACAAACAGGATCAGCATTTACTTAAGATGTTAA
GAATGAGGACTTTTAATCAGCCGAACCAAGATATTGTTACCTGTATGCATTCCCAAAGTCTAGATGCTCAGTATGTTCAGTCATATCTTT
CAGAATCAGTGAACCGATTACCCTTTTTTTGGTATTCACTCTACATCTGCCAACCTAGTTCACCTTGGTTTTGTGTCTGCTGTAGAAGGG
AACCATAACTTGGTTAAACCGTAGGGATTATCATTGTATACATGCTGTGAACATGTATATGTGCAAGTTTTAATGTATTCTATGTTGTAG
GCTTATTATTTAATTTTACCACTTCATCACTTTTGTACAGTGGCCAAGCAGACACCTCAAACTCCAGCATTTACATTAAGTGCATTTGTA
CATTTTAGGCCACTGGATCCAGATTTTATATTGGCAGTTATTGAGGGCAAAAGCAATATATTGTAACAGAATGTATAAATATTTTTGATA
AAACAGTCTATATTTTATTAAAAAATGAATTATAACACTAAAGCTGTACCTCAAAAGTCTCAAAAATAATTTGATGAAATATTTTATACA
ACTCTTCAAAGGATCCGTCTGTGGCTTTTTATACTCTTTTAGGGTTGTCTTTTTACAAACCATGACTTTCCACTTGCCTGTAGTTTTTTG
TTTGTTTTGGTTTGGTTTGATTTTATATTTTTTTCTCCTAATCTATGACTTTATTGTTTTTTCTTAGTTTAGTAATAGCATCTTTGATCC
TGTGCTTAGCATGTTAGGGTCATTATACCTCAGGAATAGCAAGCTGTTAAGTAACCATACTGAATTAACTATTTAATTACAGTGAGCTCA
TCTCTTAAAAATTGTTCAGGTGTAAATCTTATGAGAAACATGAAAAAGCACACTGATTTATGGAGAGTTGAGCTAAAAACATTTATAAAT
ATTTGCTGGGATGTTTTAGCATCTTTTCATTGTACTCTGAGAACAATTAAAATTGTCCAGAGATCATTTATATTACCTTCCAAATTGTTT
ATTACCCAAGATCCTTTGGGAGAAAATCTTATAGAATGGGGGAACAATATGTGGTTTAAAGTTATTTTAAAATGCCAGTTAATTTCCTCG
GCAAAGGACAATAGAGGAACTTAGCTTAATTGTCTGGCTTTAATTTAAACTGTGTTAATACAACATTAAAATAAAACACTAAATACTTTT
GAGGTACAGTCTGCTCACTTTTTTGGTTCTCAAATAGCAAAGAAAGTAATGTCTAAAATAGGCTCTTAGCATTAAAAACTGACAGCATTT
CGTAACTACACAGTGTACAGAATTTTTTTTTAATTGAAGTCAATCACTAAAAAAATTAGAAGGCAGGGTCTATTTACACAATTAAGCTGA
AGAAAGCACTAATTTTTTGTAGTTTAAAATATATATATATTTTAGTCAGATTTAAAATTTTAAGCTTTATAGAGTGTAAATATATTTTGC
TATTACTGTATGTGTATGTGACTGCTCAAGCACTTTGTAAAGAAATTAGGATATTTTAGAATGGTACACTATGCATTCAAATGAAATGTG
CCTTTCACTATGTCATTCTAAGAAAACAAGTGTTTTTTGCAGTCATAAATTATCACAAATGCACAAATTAAAGTCTATATAGATTGAAAT
TTGTAACTTTGGTTTTAAGTATTCTTTCCTTTTAGAAACTTCCTAATGATTAAAATATACTTTAACTTTTCTGTGTTCAAAATCTCAAAG
ACTAATTAACTTTAATAAACATTCTTGCAAGTACTTTTTGTCCTAGTGAAGGCTTAAAACCATGAACATTCAGAGCAAACTGTCCACTTC
ATTGGGAATAATGGGAAAAGTTTGTATTCTGCTCCTGTAAGGTCAGTAGCATCTTTTATTTGAAGCATATTTATGGACTGCTTACTGTGT
ATAGATACTGAGAATAGGAAGTTTTTTTTTTTAAAGCAACAAAATGTTGATGAATGAAGAACAGCCTGTTTTAATTAAGATGCAAGCACC
AGTATTGTATGTACTTTTCTCTTGTTTGAGGTTAGCTTATTTTAATTTAGGACCTGGCTTCTCAAAAAGGCAAATGAATAAAACAGAATA

>93619_93619_2_TRABD2B-PKN2_TRABD2B_chr1_48459706_ENST00000606738_PKN2_chr1_89206671_ENST00000370521_length(amino acids)=1207AA_BP=234
MRGAAQEGPPRPAGPGRMHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWTIRRDPPAYLFGTIHVPYTRVWDFIPDNSK
AAFQASTRVYFELDLTDPYTISALASCQLLPHGENLQDVLPHELYWRLKRHLDYVKLMMPSWMTPAQRGKGLYADYLFNAIAGNWERKRP
VWVMLMVNSLTERDVRFRGVPVLDLYLAQQAEKMKKTTGAVEQVEEQCHPLNNGLNFSQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDD
IKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNR
LKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFR
IEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQ
YSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQT
SWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFS
KQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEI
DESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYK
NTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVV
LGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPF
PGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFD

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Fusion Gene PPI Analysis for TRABD2B-PKN2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TRABD2B-PKN2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TRABD2B-PKN2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source