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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRAF2-DENND1C (FusionGDB2 ID:93646)

Fusion Gene Summary for TRAF2-DENND1C

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAF2-DENND1C
Fusion gene ID: 93646
HgeneTgene
Gene symbol

TRAF2

DENND1C

Gene ID

10010

79958

Gene nameTRAF family member associated NFKB activatorDENN domain containing 1C
SynonymsI-TRAF|ITRAF|TRAF2FAM31C
Cytomap

2q24.2

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionTRAF family member-associated NF-kappa-B activatorTRAF-interacting proteinDENN domain-containing protein 1CDENN/MADD domain containing 1Cconnecdenn 3family with sequence similarity 31, member C
Modification date2020031320200313
UniProtAcc

TNIK

Q8IV53

Ensembl transtripts involved in fusion geneENST00000247668, ENST00000359662, 
ENST00000536468, ENST00000482854, 
ENST00000591030, ENST00000381480, 
ENST00000543576, 
Fusion gene scores* DoF score7 X 6 X 6=2524 X 4 X 2=32
# samples 74
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TRAF2 [Title/Abstract] AND DENND1C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRAF2(139818424)-DENND1C(6475907), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRAF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DENND1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI031313TRAF2chr9

139818424

-DENND1Cchr19

6475907

+


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Fusion Gene ORF analysis for TRAF2-DENND1C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000247668ENST00000591030TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
5CDS-intronENST00000359662ENST00000591030TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
5CDS-intronENST00000536468ENST00000591030TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
In-frameENST00000247668ENST00000381480TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
In-frameENST00000247668ENST00000543576TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
In-frameENST00000359662ENST00000381480TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
In-frameENST00000359662ENST00000543576TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
In-frameENST00000536468ENST00000381480TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
In-frameENST00000536468ENST00000543576TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
intron-3CDSENST00000482854ENST00000381480TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
intron-3CDSENST00000482854ENST00000543576TRAF2chr9

139818424

-DENND1Cchr19

6475907

+
intron-intronENST00000482854ENST00000591030TRAF2chr9

139818424

-DENND1Cchr19

6475907

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000536468TRAF2chr9139818424-ENST00000381480DENND1Cchr196475907+332313391491474441
ENST00000536468TRAF2chr9139818424-ENST00000543576DENND1Cchr196475907+303213391491474441
ENST00000247668TRAF2chr9139818424-ENST00000381480DENND1Cchr196475907+32021218281353441
ENST00000247668TRAF2chr9139818424-ENST00000543576DENND1Cchr196475907+29111218281353441
ENST00000359662TRAF2chr9139818424-ENST00000381480DENND1Cchr196475907+33511367211502493
ENST00000359662TRAF2chr9139818424-ENST00000543576DENND1Cchr196475907+30601367211502493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000536468ENST00000381480TRAF2chr9139818424-DENND1Cchr196475907+0.111766070.8882339
ENST00000536468ENST00000543576TRAF2chr9139818424-DENND1Cchr196475907+0.120400580.87959945
ENST00000247668ENST00000381480TRAF2chr9139818424-DENND1Cchr196475907+0.1046608760.89533913
ENST00000247668ENST00000543576TRAF2chr9139818424-DENND1Cchr196475907+0.1168646740.8831354
ENST00000359662ENST00000381480TRAF2chr9139818424-DENND1Cchr196475907+0.130640660.8693593
ENST00000359662ENST00000543576TRAF2chr9139818424-DENND1Cchr196475907+0.144181890.85581815

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Fusion Genomic Features for TRAF2-DENND1C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRAF2-DENND1C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:139818424/chr19:6475907)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAF2

TNIK

DENND1C

Q8IV53

1360FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDENND1Cchr9:139818424chr19:6475907ENST0000038148002313_1570802.0DomainuDENN
TgeneDENND1Cchr9:139818424chr19:6475907ENST00000381480023182_3180802.0DomaincDENN
TgeneDENND1Cchr9:139818424chr19:6475907ENST00000381480023320_3980802.0DomaindDENN
TgeneDENND1Cchr9:139818424chr19:6475907ENST0000054357602113_1570758.0DomainuDENN
TgeneDENND1Cchr9:139818424chr19:6475907ENST00000543576021182_3180758.0DomaincDENN
TgeneDENND1Cchr9:139818424chr19:6475907ENST00000543576021320_3980758.0DomaindDENN
TgeneDENND1Cchr9:139818424chr19:6475907ENST00000381480023401_4050802.0MotifFXDXF motif
TgeneDENND1Cchr9:139818424chr19:6475907ENST00000381480023558_5670802.0MotifClathrin box
TgeneDENND1Cchr9:139818424chr19:6475907ENST00000543576021401_4050758.0MotifFXDXF motif
TgeneDENND1Cchr9:139818424chr19:6475907ENST00000543576021558_5670758.0MotifClathrin box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRAF2chr9:139818424chr19:6475907ENST00000247668-111299_3480502.0Coiled coilOntology_term=ECO:0000269
HgeneTRAF2chr9:139818424chr19:6475907ENST00000359662-111299_3480554.0Coiled coilOntology_term=ECO:0000269
HgeneTRAF2chr9:139818424chr19:6475907ENST00000536468-112299_3480502.0Coiled coilOntology_term=ECO:0000269
HgeneTRAF2chr9:139818424chr19:6475907ENST00000247668-111351_4960502.0DomainMATH
HgeneTRAF2chr9:139818424chr19:6475907ENST00000359662-111351_4960554.0DomainMATH
HgeneTRAF2chr9:139818424chr19:6475907ENST00000536468-112351_4960502.0DomainMATH
HgeneTRAF2chr9:139818424chr19:6475907ENST00000247668-111124_1800502.0Zinc fingerTRAF-type 1
HgeneTRAF2chr9:139818424chr19:6475907ENST00000247668-111177_2330502.0Zinc fingerTRAF-type 2
HgeneTRAF2chr9:139818424chr19:6475907ENST00000247668-11134_730502.0Zinc fingerRING-type
HgeneTRAF2chr9:139818424chr19:6475907ENST00000359662-111124_1800554.0Zinc fingerTRAF-type 1
HgeneTRAF2chr9:139818424chr19:6475907ENST00000359662-111177_2330554.0Zinc fingerTRAF-type 2
HgeneTRAF2chr9:139818424chr19:6475907ENST00000359662-11134_730554.0Zinc fingerRING-type
HgeneTRAF2chr9:139818424chr19:6475907ENST00000536468-112124_1800502.0Zinc fingerTRAF-type 1
HgeneTRAF2chr9:139818424chr19:6475907ENST00000536468-112177_2330502.0Zinc fingerTRAF-type 2
HgeneTRAF2chr9:139818424chr19:6475907ENST00000536468-11234_730502.0Zinc fingerRING-type


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Fusion Gene Sequence for TRAF2-DENND1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93646_93646_1_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000247668_DENND1C_chr19_6475907_ENST00000381480_length(transcript)=3202nt_BP=1218nt
TTCCGGGCGCGCTGCGACCGTTGGGGCTTTGTTCGCGGGGGTCACAGCTCTCATGGCTGCAGCTAGCGTGACCCCCCCTGGCTCCCTGGA
GTTGCTACAGCCCGGCTTCTCCAAGACCCTCCTGGGGACCAAGCTGGAAGCCAAGTACCTGTGCTCCGCCTGCAGAAACGTCCTCCGCAG
GCCCTTCCAGGCGCAGTGTGGCCACCGGTACTGCTCCTTCTGCCTGGCCAGCATCCTCAGCTCTGGGCCTCAGAACTGTGCTGCCTGTGT
TCACGAGGGCATATATGAAGAAGGCATTTCTATTTTAGAAAGCAGTTCGGCCTTCCCAGATAATGCTGCCCGCAGGGAGGTGGAGAGCCT
GCCGGCCGTCTGTCCCAGTGATGGATGCACCTGGAAGGGGACCCTGAAAGAATACGAGAGCTGCCACGAAGGCCGCTGCCCGCTCATGCT
GACCGAATGTCCCGCGTGCAAAGGCCTGGTCCGCCTTGGTGAAAAGGAGCGCCACCTGGAGCACGAGTGCCCGGAGAGAAGCCTGAGCTG
CCGGCATTGCCGGGCACCCTGCTGCGGAGCAGACGTGAAGGCGCACCACGAGGTCTGCCCCAAGTTCCCCTTAACTTGTGACGGCTGCGG
CAAGAAGAAGATCCCCCGGGAGAAGTTTCAGGACCACGTCAAGACTTGTGGCAAGTGTCGAGTCCCTTGCAGATTCCACGCCATCGGCTG
CCTCGAGACGGTAGAGGGTGAGAAACAGCAGGAGCACGAGGTGCAGTGGCTGCGGGAGCACCTGGCCATGCTACTGAGCTCGGTGCTGGA
GGCAAAGCCCCTCTTGGGAGACCAGAGCCACGCGGGGTCAGAGCTCCTGCAGAGGTGCGAGAGCCTGGAGAAGAAGACGGCCACTTTTGA
GAACATTGTCTGCGTCCTGAACCGGGAGGTGGAGAGGGTGGCCATGACTGCCGAGGCCTGCAGCCGGCAGCACCGGCTGGACCAAGACAA
GATTGAAGCCCTGAGTAGCAAGGTGCAGCAGCTGGAGAGGAGCATTGGCCTCAAGGACCTGGCGATGGCTGACTTGGAGCAGAAGGTCTT
GGAGATGGAGGCATCCACCTACGATGGGGTCTTCATCTGGAAGATCTCAGACTTCGCCAGGAAGCGCCAGGAAGCTGTGGCTGGCCGCAT
ACCCGCCATCTTCTCCCCAGCCTGCTGCGGTGGCCCTTCAACCAGAAGCCCAACATACCAAGATGGCAACCAGACGATAAGAAACTACCA
GAGCCGGAGCCCCAGCCCCTTTCCCTGCCATCCCTGCAAAATGCCTCGTCTTTGGATGCCACCAGCTCTTCAAAGGACTCCAGGTCCCAG
CTGATACCCTCAGAGTCCGACCAAGAAGTCACGTCTCCATCCCAGTCCTCAACAGCTTCTGCAGACCCAAGCATCTGGGGGGACCCCAAA
CCCTCTCCTCTCACAGAGCCCCTAATTCTTCATCTCACCCCTTCCCACAAGGCAGCTGAAGATTCTACAGCCCAGGAAAACCCCACTCCC
TGGCTCTCCACTGCACCCACTGAGCCCAGCCCTCCAGAAAGCCCCCAAATTCTGGCCCCCACAAAGCCCAACTTTGATATAGCCTGGACG
TCCCAGCCCCTTGATCCTTCCTCAGACCCCAGTTCTCTGGAGGACCCCAGAGCCCGGCCTCCCAAAGCCCTGCTGGCAGAGCGCGCTCAC
CTCCAGCCACGGGAGGAACCAGGAGCCCTGAATTCCCCTGCTACACCCACCAGCAACTGTCAAAAGTCCCAGCCCAGCAGCCGGCCCAGA
GTCGCTGATCTTAAGAAGTGCTTTGAGGGTTAAGAATCAGGGGTCCAAGAGAGACCCCAGTCCCTCAATAAAGCCACAAGAGCCCAAAAA
AGCTGGTTTTTTTCCTGGTGAATTTCTCTGGTGCCCTCACTCTGCTCGGAAATCCATCCCACCCACCTCTGTCCCTCCAAGGGCAGCCTC
TCTAACTGGCTCCTAGCAGGGAATTCCAGGAAGCCTCCTGGTCTTCTAGAATCCTGGCAACCTTACAATTCCTCTCGGCATTTGTCACTT
CCATCTCAGCTAATGCACCCACCAGCTCAAACACACCAATAAAGCTTTTGTTACATCTCAGACACCCCCACTGAGCCCTGAGGATGAGGG
GTGCCCGTGGGCAGAAGAAGCTCTGGACAGCAGCTTCTTGGGGTCTGGAGAAGAACTGGATTTGTTGAGCGAGATTCTGGACAGTCTTAG
CATGGGAGCCAAGAGCGCAGGCAGCCTGAGACCGAGCCAGAGTTTAGACTGCTGTCACAGAGGAGACCTGGACAGCTGCTTCAGCCTGAA
CCGGCCCCTTCGCCCCAGCAGGAGACGCCAGCTGGAAGAGGGAACTTCCGAGCCCCCAGGGGCGGGGATGGGGACTCTGTCCTGCAGAGG
GGGGGCTCTCTGAGGGCCCCAGCCCTCCCCAGCCGCTCAGACCGCCTGCAGCAACGCCTCCCAATCACTCAGCACTTTGGAAAGGCCAAG
AGTGGCTTGAAGGGGGTGCAGAGCCTTCTAATGTATAAGAAAGGTGGTGGCGCCCTCCTGCACTCAGTCAAGGCCAAGACCCAACCAGCC
GTCAAGAACATGTACCGCTCGGGGCCCTTCGATCCTATCAGCTCTGGGCCGACAATCTAAAGTTCATCGAAGCCCGGCTGGAGAAGCTCA
ACAAGGGGGAGGGCTTCTCAGATCAATTCGAGCAGGAGATCACTGGCTGCGGGGCCTCCTCAGGGCCAGCCAGTGACCTTCAGTGAGGAA
GTCTTCTTGGCCCAGAAGCCTGGGGCACCTCTGCAGGCCTTCCACCGGCGGGCTGTGCACCTGCAGCTGTTCAAACAGGTGTCCCTGCTG
AGGCTCCGGCTCAGGAAGGTCGCCCTGGCCCCCGGGGAAGGGGTGTCCCGTCTCTTCCTCAAAGCCCAGGCCCTGCTCTTCGGGGGGTAC
CGCGACGCACTCGTCTGCAGCCCGAGAGTACGAGAAAAAGCCCTGGAGGACGTCGTGGTGCTGAACGTGGACGCCAATACCTTGGAGACG
ACCTTTAACGACGTGCAGGCGCTGCCTCCAGACGTGCGCGCCCATGCCCTACCTCATTGGAGTGCACGCCAGTCTCGCCGAGCATGCGCT

>93646_93646_1_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000247668_DENND1C_chr19_6475907_ENST00000381480_length(amino acids)=441AA_BP=391
MFAGVTALMAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGI
SILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCG
ADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQS
HAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDG

--------------------------------------------------------------
>93646_93646_2_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000247668_DENND1C_chr19_6475907_ENST00000543576_length(transcript)=2911nt_BP=1218nt
TTCCGGGCGCGCTGCGACCGTTGGGGCTTTGTTCGCGGGGGTCACAGCTCTCATGGCTGCAGCTAGCGTGACCCCCCCTGGCTCCCTGGA
GTTGCTACAGCCCGGCTTCTCCAAGACCCTCCTGGGGACCAAGCTGGAAGCCAAGTACCTGTGCTCCGCCTGCAGAAACGTCCTCCGCAG
GCCCTTCCAGGCGCAGTGTGGCCACCGGTACTGCTCCTTCTGCCTGGCCAGCATCCTCAGCTCTGGGCCTCAGAACTGTGCTGCCTGTGT
TCACGAGGGCATATATGAAGAAGGCATTTCTATTTTAGAAAGCAGTTCGGCCTTCCCAGATAATGCTGCCCGCAGGGAGGTGGAGAGCCT
GCCGGCCGTCTGTCCCAGTGATGGATGCACCTGGAAGGGGACCCTGAAAGAATACGAGAGCTGCCACGAAGGCCGCTGCCCGCTCATGCT
GACCGAATGTCCCGCGTGCAAAGGCCTGGTCCGCCTTGGTGAAAAGGAGCGCCACCTGGAGCACGAGTGCCCGGAGAGAAGCCTGAGCTG
CCGGCATTGCCGGGCACCCTGCTGCGGAGCAGACGTGAAGGCGCACCACGAGGTCTGCCCCAAGTTCCCCTTAACTTGTGACGGCTGCGG
CAAGAAGAAGATCCCCCGGGAGAAGTTTCAGGACCACGTCAAGACTTGTGGCAAGTGTCGAGTCCCTTGCAGATTCCACGCCATCGGCTG
CCTCGAGACGGTAGAGGGTGAGAAACAGCAGGAGCACGAGGTGCAGTGGCTGCGGGAGCACCTGGCCATGCTACTGAGCTCGGTGCTGGA
GGCAAAGCCCCTCTTGGGAGACCAGAGCCACGCGGGGTCAGAGCTCCTGCAGAGGTGCGAGAGCCTGGAGAAGAAGACGGCCACTTTTGA
GAACATTGTCTGCGTCCTGAACCGGGAGGTGGAGAGGGTGGCCATGACTGCCGAGGCCTGCAGCCGGCAGCACCGGCTGGACCAAGACAA
GATTGAAGCCCTGAGTAGCAAGGTGCAGCAGCTGGAGAGGAGCATTGGCCTCAAGGACCTGGCGATGGCTGACTTGGAGCAGAAGGTCTT
GGAGATGGAGGCATCCACCTACGATGGGGTCTTCATCTGGAAGATCTCAGACTTCGCCAGGAAGCGCCAGGAAGCTGTGGCTGGCCGCAT
ACCCGCCATCTTCTCCCCAGCCTGCTGCGGTGGCCCTTCAACCAGAAGCCCAACATACCAAGATGGCAACCAGACGATAAGAAACTACCA
GAGCCGGAGCCCCAGCCCCTTTCCCTGCCATCCCTGCAAAATGCCTCGTCTTTGGATGCCACCAGCTCTTCAAAGGACTCCAGGTCCCAG
CTGATACCCTCAGAGTCCGACCAAGAAGTCACGTCTCCATCCCAGTCCTCAACAGCTTCTGCAGACCCAAGCATCTGGGGGGACCCCAAA
CCCTCTCCTCTCACAGAGCCCCTAATTCTTCATCTCACCCCTTCCCACAAGGCAGCTGAAGATTCTACAGCCCAGGAAAACCCCACTCCC
TGGCTCTCCACTGCACCCACTGAGCCCAGCCCTCCAGAAAGCCCCCAAATTCTGGCCCCCACAAAGCCCAACTTTGATATAGCCTGGACG
TCCCAGCCCCTTGATCCTTCCTCAGACCCCAGTTCTCTGGAGGACCCCAGAGCCCGGCCTCCCAAAGCCCTGCTGGCAGAGCGCGCTCAC
CTCCAGCCACGGGAGGAACCAGGAGCCCTGAATTCCCCTGCTACACCCACCAGCAACTGTCAAAAGTCCCAGCCCAGCAGCCGGCCCAGA
GTCGCTGATCTTAAGAAGTGCTTTGAGGGTTAAGAATCAGACACCCCCACTGAGCCCTGAGGATGAGGGGTGCCCGTGGGCAGAAGAAGC
TCTGGACAGCAGCTTCTTGGGGTCTGGAGAAGAACTGGATTTGTTGAGCGAGATTCTGGACAGTCTTAGCATGGGAGCCAAGAGCGCAGG
CAGCCTGAGACCGAGCCAGAGTTTAGACTGCTGTCACAGAGGAGACCTGGACAGCTGCTTCAGCCTGAACCGGCCCCTTCGCCCCAGCAG
GAGACGCCAGCTGGAAGAGGGAACTTCCGAGCCCCCAGGGGCGGGGATGGGGACTCTGTCCTGCAGAGGGGGGGCTCTCTGAGGGCCCCA
GCCCTCCCCAGCCGCTCAGACCGCCTGCAGCAACGCCTCCCAATCACTCAGCACTTTGGAAAGGCCAAGAGTGGCTTGAAGGGGGTGCAG
AGCCTTCTAATGTATAAGAAAGGTGGTGGCGCCCTCCTGCACTCAGTCAAGGCCAAGACCCAACCAGCCGTCAAGAACATGTACCGCTCG
GGGCCCTTCGATCCTATCAGCTCTGGGCCGACAATCTAAAGTTCATCGAAGCCCGGCTGGAGAAGCTCAACAAGGGGGAGGGCTTCTCAG
ATCAATTCGAGCAGGAGATCACTGGCTGCGGGGCCTCCTCAGGGCCAGCCAGTGACCTTCAGTGAGGAAGTCTTCTTGGCCCAGAAGCCT
GGGGCACCTCTGCAGGCCTTCCACCGGCGGGCTGTGCACCTGCAGCTGTTCAAACAGGTGTCCCTGCTGAGGCTCCGGCTCAGGAAGGTC
GCCCTGGCCCCCGGGGAAGGGGTGTCCCGTCTCTTCCTCAAAGCCCAGGCCCTGCTCTTCGGGGGGTACCGCGACGCACTCGTCTGCAGC
CCGAGAGTACGAGAAAAAGCCCTGGAGGACGTCGTGGTGCTGAACGTGGACGCCAATACCTTGGAGACGACCTTTAACGACGTGCAGGCG
CTGCCTCCAGACGTGCGCGCCCATGCCCTACCTCATTGGAGTGCACGCCAGTCTCGCCGAGCATGCGCTGGGAGCACGTGCTGATCCCCA

>93646_93646_2_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000247668_DENND1C_chr19_6475907_ENST00000543576_length(amino acids)=441AA_BP=391
MFAGVTALMAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGI
SILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCG
ADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQS
HAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDG

--------------------------------------------------------------
>93646_93646_3_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000359662_DENND1C_chr19_6475907_ENST00000381480_length(transcript)=3351nt_BP=1367nt
CGCGCTGCGACCGTTGGGGCTTTGTTCGCGGGGGTCACAGCTCTCATGGCTGCAGCTAGCGTGACCCCCCCTGGCTCCCTGGAGTTGCTA
CAGCCCGGCTTCTCCAAGACCCTCCTGGGGACCAAGCTGGAAGCCAAGTACCTGTGCTCCGCCTGCAGAAACGTCCTCCGCAGGCCCTTC
CAGGCGCAGTGTGGCCACCGGTACTGCTCCTTCTGCCTGGCCAGCATCCTCAGCTCTGGGCCTCAGAACTGTGCTGCCTGTGTTCACGAG
GGCATATATGAAGAAGGCATTTCTATTTTAGAAAGCAGTTCGGCCTTCCCAGATAATGCTGCCCGCAGGGAGGTGGAGAGCCTGCCGGCC
GTCTGTCCCAGTGATGGATGCACCTGGAAGGGGACCCTGAAAGAATACGAGGTAAAGATGCCTGCGTGTGGCATGGTGACAGAAGCTCCA
GCAGTCGGGAGTCGTCCACGCTCCCCAAGCAGTTATGACCTTGTCCTGCACGTTCCTCTCACTGGGGCTGAAGCCTGTCTGATGTCTGTG
GAGGAAGAGACGGAGCTGCTCCTTAGAAGCTGCCACGAAGGCCGCTGCCCGCTCATGCTGACCGAATGTCCCGCGTGCAAAGGCCTGGTC
CGCCTTGGTGAAAAGGAGCGCCACCTGGAGCACGAGTGCCCGGAGAGAAGCCTGAGCTGCCGGCATTGCCGGGCACCCTGCTGCGGAGCA
GACGTGAAGGCGCACCACGAGGTCTGCCCCAAGTTCCCCTTAACTTGTGACGGCTGCGGCAAGAAGAAGATCCCCCGGGAGAAGTTTCAG
GACCACGTCAAGACTTGTGGCAAGTGTCGAGTCCCTTGCAGATTCCACGCCATCGGCTGCCTCGAGACGGTAGAGGGTGAGAAACAGCAG
GAGCACGAGGTGCAGTGGCTGCGGGAGCACCTGGCCATGCTACTGAGCTCGGTGCTGGAGGCAAAGCCCCTCTTGGGAGACCAGAGCCAC
GCGGGGTCAGAGCTCCTGCAGAGGTGCGAGAGCCTGGAGAAGAAGACGGCCACTTTTGAGAACATTGTCTGCGTCCTGAACCGGGAGGTG
GAGAGGGTGGCCATGACTGCCGAGGCCTGCAGCCGGCAGCACCGGCTGGACCAAGACAAGATTGAAGCCCTGAGTAGCAAGGTGCAGCAG
CTGGAGAGGAGCATTGGCCTCAAGGACCTGGCGATGGCTGACTTGGAGCAGAAGGTCTTGGAGATGGAGGCATCCACCTACGATGGGGTC
TTCATCTGGAAGATCTCAGACTTCGCCAGGAAGCGCCAGGAAGCTGTGGCTGGCCGCATACCCGCCATCTTCTCCCCAGCCTGCTGCGGT
GGCCCTTCAACCAGAAGCCCAACATACCAAGATGGCAACCAGACGATAAGAAACTACCAGAGCCGGAGCCCCAGCCCCTTTCCCTGCCAT
CCCTGCAAAATGCCTCGTCTTTGGATGCCACCAGCTCTTCAAAGGACTCCAGGTCCCAGCTGATACCCTCAGAGTCCGACCAAGAAGTCA
CGTCTCCATCCCAGTCCTCAACAGCTTCTGCAGACCCAAGCATCTGGGGGGACCCCAAACCCTCTCCTCTCACAGAGCCCCTAATTCTTC
ATCTCACCCCTTCCCACAAGGCAGCTGAAGATTCTACAGCCCAGGAAAACCCCACTCCCTGGCTCTCCACTGCACCCACTGAGCCCAGCC
CTCCAGAAAGCCCCCAAATTCTGGCCCCCACAAAGCCCAACTTTGATATAGCCTGGACGTCCCAGCCCCTTGATCCTTCCTCAGACCCCA
GTTCTCTGGAGGACCCCAGAGCCCGGCCTCCCAAAGCCCTGCTGGCAGAGCGCGCTCACCTCCAGCCACGGGAGGAACCAGGAGCCCTGA
ATTCCCCTGCTACACCCACCAGCAACTGTCAAAAGTCCCAGCCCAGCAGCCGGCCCAGAGTCGCTGATCTTAAGAAGTGCTTTGAGGGTT
AAGAATCAGGGGTCCAAGAGAGACCCCAGTCCCTCAATAAAGCCACAAGAGCCCAAAAAAGCTGGTTTTTTTCCTGGTGAATTTCTCTGG
TGCCCTCACTCTGCTCGGAAATCCATCCCACCCACCTCTGTCCCTCCAAGGGCAGCCTCTCTAACTGGCTCCTAGCAGGGAATTCCAGGA
AGCCTCCTGGTCTTCTAGAATCCTGGCAACCTTACAATTCCTCTCGGCATTTGTCACTTCCATCTCAGCTAATGCACCCACCAGCTCAAA
CACACCAATAAAGCTTTTGTTACATCTCAGACACCCCCACTGAGCCCTGAGGATGAGGGGTGCCCGTGGGCAGAAGAAGCTCTGGACAGC
AGCTTCTTGGGGTCTGGAGAAGAACTGGATTTGTTGAGCGAGATTCTGGACAGTCTTAGCATGGGAGCCAAGAGCGCAGGCAGCCTGAGA
CCGAGCCAGAGTTTAGACTGCTGTCACAGAGGAGACCTGGACAGCTGCTTCAGCCTGAACCGGCCCCTTCGCCCCAGCAGGAGACGCCAG
CTGGAAGAGGGAACTTCCGAGCCCCCAGGGGCGGGGATGGGGACTCTGTCCTGCAGAGGGGGGGCTCTCTGAGGGCCCCAGCCCTCCCCA
GCCGCTCAGACCGCCTGCAGCAACGCCTCCCAATCACTCAGCACTTTGGAAAGGCCAAGAGTGGCTTGAAGGGGGTGCAGAGCCTTCTAA
TGTATAAGAAAGGTGGTGGCGCCCTCCTGCACTCAGTCAAGGCCAAGACCCAACCAGCCGTCAAGAACATGTACCGCTCGGGGCCCTTCG
ATCCTATCAGCTCTGGGCCGACAATCTAAAGTTCATCGAAGCCCGGCTGGAGAAGCTCAACAAGGGGGAGGGCTTCTCAGATCAATTCGA
GCAGGAGATCACTGGCTGCGGGGCCTCCTCAGGGCCAGCCAGTGACCTTCAGTGAGGAAGTCTTCTTGGCCCAGAAGCCTGGGGCACCTC
TGCAGGCCTTCCACCGGCGGGCTGTGCACCTGCAGCTGTTCAAACAGGTGTCCCTGCTGAGGCTCCGGCTCAGGAAGGTCGCCCTGGCCC
CCGGGGAAGGGGTGTCCCGTCTCTTCCTCAAAGCCCAGGCCCTGCTCTTCGGGGGGTACCGCGACGCACTCGTCTGCAGCCCGAGAGTAC
GAGAAAAAGCCCTGGAGGACGTCGTGGTGCTGAACGTGGACGCCAATACCTTGGAGACGACCTTTAACGACGTGCAGGCGCTGCCTCCAG
ACGTGCGCGCCCATGCCCTACCTCATTGGAGTGCACGCCAGTCTCGCCGAGCATGCGCTGGGAGCACGTGCTGATCCCCACGCTGCCCCC

>93646_93646_3_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000359662_DENND1C_chr19_6475907_ENST00000381480_length(amino acids)=493AA_BP=443
MFAGVTALMAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGI
SILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYEVKMPACGMVTEAPAVGSRPRSPSSYDLVLHVPLTGAEACLMSVEEETELL
LRSCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCG
KCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTA
EACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPACCGGPSTRSP

--------------------------------------------------------------
>93646_93646_4_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000359662_DENND1C_chr19_6475907_ENST00000543576_length(transcript)=3060nt_BP=1367nt
CGCGCTGCGACCGTTGGGGCTTTGTTCGCGGGGGTCACAGCTCTCATGGCTGCAGCTAGCGTGACCCCCCCTGGCTCCCTGGAGTTGCTA
CAGCCCGGCTTCTCCAAGACCCTCCTGGGGACCAAGCTGGAAGCCAAGTACCTGTGCTCCGCCTGCAGAAACGTCCTCCGCAGGCCCTTC
CAGGCGCAGTGTGGCCACCGGTACTGCTCCTTCTGCCTGGCCAGCATCCTCAGCTCTGGGCCTCAGAACTGTGCTGCCTGTGTTCACGAG
GGCATATATGAAGAAGGCATTTCTATTTTAGAAAGCAGTTCGGCCTTCCCAGATAATGCTGCCCGCAGGGAGGTGGAGAGCCTGCCGGCC
GTCTGTCCCAGTGATGGATGCACCTGGAAGGGGACCCTGAAAGAATACGAGGTAAAGATGCCTGCGTGTGGCATGGTGACAGAAGCTCCA
GCAGTCGGGAGTCGTCCACGCTCCCCAAGCAGTTATGACCTTGTCCTGCACGTTCCTCTCACTGGGGCTGAAGCCTGTCTGATGTCTGTG
GAGGAAGAGACGGAGCTGCTCCTTAGAAGCTGCCACGAAGGCCGCTGCCCGCTCATGCTGACCGAATGTCCCGCGTGCAAAGGCCTGGTC
CGCCTTGGTGAAAAGGAGCGCCACCTGGAGCACGAGTGCCCGGAGAGAAGCCTGAGCTGCCGGCATTGCCGGGCACCCTGCTGCGGAGCA
GACGTGAAGGCGCACCACGAGGTCTGCCCCAAGTTCCCCTTAACTTGTGACGGCTGCGGCAAGAAGAAGATCCCCCGGGAGAAGTTTCAG
GACCACGTCAAGACTTGTGGCAAGTGTCGAGTCCCTTGCAGATTCCACGCCATCGGCTGCCTCGAGACGGTAGAGGGTGAGAAACAGCAG
GAGCACGAGGTGCAGTGGCTGCGGGAGCACCTGGCCATGCTACTGAGCTCGGTGCTGGAGGCAAAGCCCCTCTTGGGAGACCAGAGCCAC
GCGGGGTCAGAGCTCCTGCAGAGGTGCGAGAGCCTGGAGAAGAAGACGGCCACTTTTGAGAACATTGTCTGCGTCCTGAACCGGGAGGTG
GAGAGGGTGGCCATGACTGCCGAGGCCTGCAGCCGGCAGCACCGGCTGGACCAAGACAAGATTGAAGCCCTGAGTAGCAAGGTGCAGCAG
CTGGAGAGGAGCATTGGCCTCAAGGACCTGGCGATGGCTGACTTGGAGCAGAAGGTCTTGGAGATGGAGGCATCCACCTACGATGGGGTC
TTCATCTGGAAGATCTCAGACTTCGCCAGGAAGCGCCAGGAAGCTGTGGCTGGCCGCATACCCGCCATCTTCTCCCCAGCCTGCTGCGGT
GGCCCTTCAACCAGAAGCCCAACATACCAAGATGGCAACCAGACGATAAGAAACTACCAGAGCCGGAGCCCCAGCCCCTTTCCCTGCCAT
CCCTGCAAAATGCCTCGTCTTTGGATGCCACCAGCTCTTCAAAGGACTCCAGGTCCCAGCTGATACCCTCAGAGTCCGACCAAGAAGTCA
CGTCTCCATCCCAGTCCTCAACAGCTTCTGCAGACCCAAGCATCTGGGGGGACCCCAAACCCTCTCCTCTCACAGAGCCCCTAATTCTTC
ATCTCACCCCTTCCCACAAGGCAGCTGAAGATTCTACAGCCCAGGAAAACCCCACTCCCTGGCTCTCCACTGCACCCACTGAGCCCAGCC
CTCCAGAAAGCCCCCAAATTCTGGCCCCCACAAAGCCCAACTTTGATATAGCCTGGACGTCCCAGCCCCTTGATCCTTCCTCAGACCCCA
GTTCTCTGGAGGACCCCAGAGCCCGGCCTCCCAAAGCCCTGCTGGCAGAGCGCGCTCACCTCCAGCCACGGGAGGAACCAGGAGCCCTGA
ATTCCCCTGCTACACCCACCAGCAACTGTCAAAAGTCCCAGCCCAGCAGCCGGCCCAGAGTCGCTGATCTTAAGAAGTGCTTTGAGGGTT
AAGAATCAGACACCCCCACTGAGCCCTGAGGATGAGGGGTGCCCGTGGGCAGAAGAAGCTCTGGACAGCAGCTTCTTGGGGTCTGGAGAA
GAACTGGATTTGTTGAGCGAGATTCTGGACAGTCTTAGCATGGGAGCCAAGAGCGCAGGCAGCCTGAGACCGAGCCAGAGTTTAGACTGC
TGTCACAGAGGAGACCTGGACAGCTGCTTCAGCCTGAACCGGCCCCTTCGCCCCAGCAGGAGACGCCAGCTGGAAGAGGGAACTTCCGAG
CCCCCAGGGGCGGGGATGGGGACTCTGTCCTGCAGAGGGGGGGCTCTCTGAGGGCCCCAGCCCTCCCCAGCCGCTCAGACCGCCTGCAGC
AACGCCTCCCAATCACTCAGCACTTTGGAAAGGCCAAGAGTGGCTTGAAGGGGGTGCAGAGCCTTCTAATGTATAAGAAAGGTGGTGGCG
CCCTCCTGCACTCAGTCAAGGCCAAGACCCAACCAGCCGTCAAGAACATGTACCGCTCGGGGCCCTTCGATCCTATCAGCTCTGGGCCGA
CAATCTAAAGTTCATCGAAGCCCGGCTGGAGAAGCTCAACAAGGGGGAGGGCTTCTCAGATCAATTCGAGCAGGAGATCACTGGCTGCGG
GGCCTCCTCAGGGCCAGCCAGTGACCTTCAGTGAGGAAGTCTTCTTGGCCCAGAAGCCTGGGGCACCTCTGCAGGCCTTCCACCGGCGGG
CTGTGCACCTGCAGCTGTTCAAACAGGTGTCCCTGCTGAGGCTCCGGCTCAGGAAGGTCGCCCTGGCCCCCGGGGAAGGGGTGTCCCGTC
TCTTCCTCAAAGCCCAGGCCCTGCTCTTCGGGGGGTACCGCGACGCACTCGTCTGCAGCCCGAGAGTACGAGAAAAAGCCCTGGAGGACG
TCGTGGTGCTGAACGTGGACGCCAATACCTTGGAGACGACCTTTAACGACGTGCAGGCGCTGCCTCCAGACGTGCGCGCCCATGCCCTAC
CTCATTGGAGTGCACGCCAGTCTCGCCGAGCATGCGCTGGGAGCACGTGCTGATCCCCACGCTGCCCCCACACCTGCTGGACTACTGCTG

>93646_93646_4_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000359662_DENND1C_chr19_6475907_ENST00000543576_length(amino acids)=493AA_BP=443
MFAGVTALMAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGI
SILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYEVKMPACGMVTEAPAVGSRPRSPSSYDLVLHVPLTGAEACLMSVEEETELL
LRSCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCG
KCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTA
EACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPACCGGPSTRSP

--------------------------------------------------------------
>93646_93646_5_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000536468_DENND1C_chr19_6475907_ENST00000381480_length(transcript)=3323nt_BP=1339nt
GAAACCAGCTTCCCTCGGAGGCTGCAGCACAGGGCTGACATGCAAACGTCTGAAAAAGAGGCAAGCTCTCGGTGTGAGCAAGTGGACTGC
GGCTATTTGAGGAAGGAGCCCACGTGGGAATCCCCTGAGCTGCGCCATGGCCAGAGGCTTTGTTCGCGGGGGTCACAGCTCTCATGGCTG
CAGCTAGCGTGACCCCCCCTGGCTCCCTGGAGTTGCTACAGCCCGGCTTCTCCAAGACCCTCCTGGGGACCAAGCTGGAAGCCAAGTACC
TGTGCTCCGCCTGCAGAAACGTCCTCCGCAGGCCCTTCCAGGCGCAGTGTGGCCACCGGTACTGCTCCTTCTGCCTGGCCAGCATCCTCA
GCTCTGGGCCTCAGAACTGTGCTGCCTGTGTTCACGAGGGCATATATGAAGAAGGCATTTCTATTTTAGAAAGCAGTTCGGCCTTCCCAG
ATAATGCTGCCCGCAGGGAGGTGGAGAGCCTGCCGGCCGTCTGTCCCAGTGATGGATGCACCTGGAAGGGGACCCTGAAAGAATACGAGA
GCTGCCACGAAGGCCGCTGCCCGCTCATGCTGACCGAATGTCCCGCGTGCAAAGGCCTGGTCCGCCTTGGTGAAAAGGAGCGCCACCTGG
AGCACGAGTGCCCGGAGAGAAGCCTGAGCTGCCGGCATTGCCGGGCACCCTGCTGCGGAGCAGACGTGAAGGCGCACCACGAGGTCTGCC
CCAAGTTCCCCTTAACTTGTGACGGCTGCGGCAAGAAGAAGATCCCCCGGGAGAAGTTTCAGGACCACGTCAAGACTTGTGGCAAGTGTC
GAGTCCCTTGCAGATTCCACGCCATCGGCTGCCTCGAGACGGTAGAGGGTGAGAAACAGCAGGAGCACGAGGTGCAGTGGCTGCGGGAGC
ACCTGGCCATGCTACTGAGCTCGGTGCTGGAGGCAAAGCCCCTCTTGGGAGACCAGAGCCACGCGGGGTCAGAGCTCCTGCAGAGGTGCG
AGAGCCTGGAGAAGAAGACGGCCACTTTTGAGAACATTGTCTGCGTCCTGAACCGGGAGGTGGAGAGGGTGGCCATGACTGCCGAGGCCT
GCAGCCGGCAGCACCGGCTGGACCAAGACAAGATTGAAGCCCTGAGTAGCAAGGTGCAGCAGCTGGAGAGGAGCATTGGCCTCAAGGACC
TGGCGATGGCTGACTTGGAGCAGAAGGTCTTGGAGATGGAGGCATCCACCTACGATGGGGTCTTCATCTGGAAGATCTCAGACTTCGCCA
GGAAGCGCCAGGAAGCTGTGGCTGGCCGCATACCCGCCATCTTCTCCCCAGCCTGCTGCGGTGGCCCTTCAACCAGAAGCCCAACATACC
AAGATGGCAACCAGACGATAAGAAACTACCAGAGCCGGAGCCCCAGCCCCTTTCCCTGCCATCCCTGCAAAATGCCTCGTCTTTGGATGC
CACCAGCTCTTCAAAGGACTCCAGGTCCCAGCTGATACCCTCAGAGTCCGACCAAGAAGTCACGTCTCCATCCCAGTCCTCAACAGCTTC
TGCAGACCCAAGCATCTGGGGGGACCCCAAACCCTCTCCTCTCACAGAGCCCCTAATTCTTCATCTCACCCCTTCCCACAAGGCAGCTGA
AGATTCTACAGCCCAGGAAAACCCCACTCCCTGGCTCTCCACTGCACCCACTGAGCCCAGCCCTCCAGAAAGCCCCCAAATTCTGGCCCC
CACAAAGCCCAACTTTGATATAGCCTGGACGTCCCAGCCCCTTGATCCTTCCTCAGACCCCAGTTCTCTGGAGGACCCCAGAGCCCGGCC
TCCCAAAGCCCTGCTGGCAGAGCGCGCTCACCTCCAGCCACGGGAGGAACCAGGAGCCCTGAATTCCCCTGCTACACCCACCAGCAACTG
TCAAAAGTCCCAGCCCAGCAGCCGGCCCAGAGTCGCTGATCTTAAGAAGTGCTTTGAGGGTTAAGAATCAGGGGTCCAAGAGAGACCCCA
GTCCCTCAATAAAGCCACAAGAGCCCAAAAAAGCTGGTTTTTTTCCTGGTGAATTTCTCTGGTGCCCTCACTCTGCTCGGAAATCCATCC
CACCCACCTCTGTCCCTCCAAGGGCAGCCTCTCTAACTGGCTCCTAGCAGGGAATTCCAGGAAGCCTCCTGGTCTTCTAGAATCCTGGCA
ACCTTACAATTCCTCTCGGCATTTGTCACTTCCATCTCAGCTAATGCACCCACCAGCTCAAACACACCAATAAAGCTTTTGTTACATCTC
AGACACCCCCACTGAGCCCTGAGGATGAGGGGTGCCCGTGGGCAGAAGAAGCTCTGGACAGCAGCTTCTTGGGGTCTGGAGAAGAACTGG
ATTTGTTGAGCGAGATTCTGGACAGTCTTAGCATGGGAGCCAAGAGCGCAGGCAGCCTGAGACCGAGCCAGAGTTTAGACTGCTGTCACA
GAGGAGACCTGGACAGCTGCTTCAGCCTGAACCGGCCCCTTCGCCCCAGCAGGAGACGCCAGCTGGAAGAGGGAACTTCCGAGCCCCCAG
GGGCGGGGATGGGGACTCTGTCCTGCAGAGGGGGGGCTCTCTGAGGGCCCCAGCCCTCCCCAGCCGCTCAGACCGCCTGCAGCAACGCCT
CCCAATCACTCAGCACTTTGGAAAGGCCAAGAGTGGCTTGAAGGGGGTGCAGAGCCTTCTAATGTATAAGAAAGGTGGTGGCGCCCTCCT
GCACTCAGTCAAGGCCAAGACCCAACCAGCCGTCAAGAACATGTACCGCTCGGGGCCCTTCGATCCTATCAGCTCTGGGCCGACAATCTA
AAGTTCATCGAAGCCCGGCTGGAGAAGCTCAACAAGGGGGAGGGCTTCTCAGATCAATTCGAGCAGGAGATCACTGGCTGCGGGGCCTCC
TCAGGGCCAGCCAGTGACCTTCAGTGAGGAAGTCTTCTTGGCCCAGAAGCCTGGGGCACCTCTGCAGGCCTTCCACCGGCGGGCTGTGCA
CCTGCAGCTGTTCAAACAGGTGTCCCTGCTGAGGCTCCGGCTCAGGAAGGTCGCCCTGGCCCCCGGGGAAGGGGTGTCCCGTCTCTTCCT
CAAAGCCCAGGCCCTGCTCTTCGGGGGGTACCGCGACGCACTCGTCTGCAGCCCGAGAGTACGAGAAAAAGCCCTGGAGGACGTCGTGGT
GCTGAACGTGGACGCCAATACCTTGGAGACGACCTTTAACGACGTGCAGGCGCTGCCTCCAGACGTGCGCGCCCATGCCCTACCTCATTG

>93646_93646_5_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000536468_DENND1C_chr19_6475907_ENST00000381480_length(amino acids)=441AA_BP=391
MFAGVTALMAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGI
SILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCG
ADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQS
HAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDG

--------------------------------------------------------------
>93646_93646_6_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000536468_DENND1C_chr19_6475907_ENST00000543576_length(transcript)=3032nt_BP=1339nt
GAAACCAGCTTCCCTCGGAGGCTGCAGCACAGGGCTGACATGCAAACGTCTGAAAAAGAGGCAAGCTCTCGGTGTGAGCAAGTGGACTGC
GGCTATTTGAGGAAGGAGCCCACGTGGGAATCCCCTGAGCTGCGCCATGGCCAGAGGCTTTGTTCGCGGGGGTCACAGCTCTCATGGCTG
CAGCTAGCGTGACCCCCCCTGGCTCCCTGGAGTTGCTACAGCCCGGCTTCTCCAAGACCCTCCTGGGGACCAAGCTGGAAGCCAAGTACC
TGTGCTCCGCCTGCAGAAACGTCCTCCGCAGGCCCTTCCAGGCGCAGTGTGGCCACCGGTACTGCTCCTTCTGCCTGGCCAGCATCCTCA
GCTCTGGGCCTCAGAACTGTGCTGCCTGTGTTCACGAGGGCATATATGAAGAAGGCATTTCTATTTTAGAAAGCAGTTCGGCCTTCCCAG
ATAATGCTGCCCGCAGGGAGGTGGAGAGCCTGCCGGCCGTCTGTCCCAGTGATGGATGCACCTGGAAGGGGACCCTGAAAGAATACGAGA
GCTGCCACGAAGGCCGCTGCCCGCTCATGCTGACCGAATGTCCCGCGTGCAAAGGCCTGGTCCGCCTTGGTGAAAAGGAGCGCCACCTGG
AGCACGAGTGCCCGGAGAGAAGCCTGAGCTGCCGGCATTGCCGGGCACCCTGCTGCGGAGCAGACGTGAAGGCGCACCACGAGGTCTGCC
CCAAGTTCCCCTTAACTTGTGACGGCTGCGGCAAGAAGAAGATCCCCCGGGAGAAGTTTCAGGACCACGTCAAGACTTGTGGCAAGTGTC
GAGTCCCTTGCAGATTCCACGCCATCGGCTGCCTCGAGACGGTAGAGGGTGAGAAACAGCAGGAGCACGAGGTGCAGTGGCTGCGGGAGC
ACCTGGCCATGCTACTGAGCTCGGTGCTGGAGGCAAAGCCCCTCTTGGGAGACCAGAGCCACGCGGGGTCAGAGCTCCTGCAGAGGTGCG
AGAGCCTGGAGAAGAAGACGGCCACTTTTGAGAACATTGTCTGCGTCCTGAACCGGGAGGTGGAGAGGGTGGCCATGACTGCCGAGGCCT
GCAGCCGGCAGCACCGGCTGGACCAAGACAAGATTGAAGCCCTGAGTAGCAAGGTGCAGCAGCTGGAGAGGAGCATTGGCCTCAAGGACC
TGGCGATGGCTGACTTGGAGCAGAAGGTCTTGGAGATGGAGGCATCCACCTACGATGGGGTCTTCATCTGGAAGATCTCAGACTTCGCCA
GGAAGCGCCAGGAAGCTGTGGCTGGCCGCATACCCGCCATCTTCTCCCCAGCCTGCTGCGGTGGCCCTTCAACCAGAAGCCCAACATACC
AAGATGGCAACCAGACGATAAGAAACTACCAGAGCCGGAGCCCCAGCCCCTTTCCCTGCCATCCCTGCAAAATGCCTCGTCTTTGGATGC
CACCAGCTCTTCAAAGGACTCCAGGTCCCAGCTGATACCCTCAGAGTCCGACCAAGAAGTCACGTCTCCATCCCAGTCCTCAACAGCTTC
TGCAGACCCAAGCATCTGGGGGGACCCCAAACCCTCTCCTCTCACAGAGCCCCTAATTCTTCATCTCACCCCTTCCCACAAGGCAGCTGA
AGATTCTACAGCCCAGGAAAACCCCACTCCCTGGCTCTCCACTGCACCCACTGAGCCCAGCCCTCCAGAAAGCCCCCAAATTCTGGCCCC
CACAAAGCCCAACTTTGATATAGCCTGGACGTCCCAGCCCCTTGATCCTTCCTCAGACCCCAGTTCTCTGGAGGACCCCAGAGCCCGGCC
TCCCAAAGCCCTGCTGGCAGAGCGCGCTCACCTCCAGCCACGGGAGGAACCAGGAGCCCTGAATTCCCCTGCTACACCCACCAGCAACTG
TCAAAAGTCCCAGCCCAGCAGCCGGCCCAGAGTCGCTGATCTTAAGAAGTGCTTTGAGGGTTAAGAATCAGACACCCCCACTGAGCCCTG
AGGATGAGGGGTGCCCGTGGGCAGAAGAAGCTCTGGACAGCAGCTTCTTGGGGTCTGGAGAAGAACTGGATTTGTTGAGCGAGATTCTGG
ACAGTCTTAGCATGGGAGCCAAGAGCGCAGGCAGCCTGAGACCGAGCCAGAGTTTAGACTGCTGTCACAGAGGAGACCTGGACAGCTGCT
TCAGCCTGAACCGGCCCCTTCGCCCCAGCAGGAGACGCCAGCTGGAAGAGGGAACTTCCGAGCCCCCAGGGGCGGGGATGGGGACTCTGT
CCTGCAGAGGGGGGGCTCTCTGAGGGCCCCAGCCCTCCCCAGCCGCTCAGACCGCCTGCAGCAACGCCTCCCAATCACTCAGCACTTTGG
AAAGGCCAAGAGTGGCTTGAAGGGGGTGCAGAGCCTTCTAATGTATAAGAAAGGTGGTGGCGCCCTCCTGCACTCAGTCAAGGCCAAGAC
CCAACCAGCCGTCAAGAACATGTACCGCTCGGGGCCCTTCGATCCTATCAGCTCTGGGCCGACAATCTAAAGTTCATCGAAGCCCGGCTG
GAGAAGCTCAACAAGGGGGAGGGCTTCTCAGATCAATTCGAGCAGGAGATCACTGGCTGCGGGGCCTCCTCAGGGCCAGCCAGTGACCTT
CAGTGAGGAAGTCTTCTTGGCCCAGAAGCCTGGGGCACCTCTGCAGGCCTTCCACCGGCGGGCTGTGCACCTGCAGCTGTTCAAACAGGT
GTCCCTGCTGAGGCTCCGGCTCAGGAAGGTCGCCCTGGCCCCCGGGGAAGGGGTGTCCCGTCTCTTCCTCAAAGCCCAGGCCCTGCTCTT
CGGGGGGTACCGCGACGCACTCGTCTGCAGCCCGAGAGTACGAGAAAAAGCCCTGGAGGACGTCGTGGTGCTGAACGTGGACGCCAATAC
CTTGGAGACGACCTTTAACGACGTGCAGGCGCTGCCTCCAGACGTGCGCGCCCATGCCCTACCTCATTGGAGTGCACGCCAGTCTCGCCG

>93646_93646_6_TRAF2-DENND1C_TRAF2_chr9_139818424_ENST00000536468_DENND1C_chr19_6475907_ENST00000543576_length(amino acids)=441AA_BP=391
MFAGVTALMAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGI
SILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCG
ADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQS
HAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRAF2-DENND1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRAF2-DENND1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRAF2-DENND1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource