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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRAF3IP2-REV3L (FusionGDB2 ID:93665)

Fusion Gene Summary for TRAF3IP2-REV3L

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAF3IP2-REV3L
Fusion gene ID: 93665
HgeneTgene
Gene symbol

TRAF3IP2

REV3L

Gene ID

10758

5980

Gene nameTRAF3 interacting protein 2REV3 like, DNA directed polymerase zeta catalytic subunit
SynonymsACT1|C6orf2|C6orf4|C6orf5|C6orf6|CANDF8|CIKS|PSORS13POLZ|REV3
Cytomap

6q21

6q21

Type of geneprotein-codingprotein-coding
Descriptionadapter protein CIKSNFkB-activating protein ACT1connection to IKK and SAPK/JNKnuclear factor NF-kappa-B activator 1symbol withdrawn, see C6orf4DNA polymerase zeta catalytic subunitREV3-like, polymerase (DNA directed), zeta, catalytic subunitRev-3, yeast, homolog-like (polymerase, DNA, zeta)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000340026, ENST00000359831, 
ENST00000368761, ENST00000392556, 
ENST00000368731, ENST00000368735, 
ENST00000462119, ENST00000358835, 
ENST00000368802, ENST00000368805, 
ENST00000435970, 
Fusion gene scores* DoF score3 X 4 X 4=485 X 5 X 3=75
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRAF3IP2 [Title/Abstract] AND REV3L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointREV3L(111803953)-TRAF3IP2(111897024), # samples:3
TRAF3IP2(111901400)-REV3L(111654570), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRAF3IP2

GO:0002230

positive regulation of defense response to virus by host

23066157


check buttonFusion gene breakpoints across TRAF3IP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across REV3L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-HM-A6W2-01ATRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-


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Fusion Gene ORF analysis for TRAF3IP2-REV3L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000340026ENST00000462119TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
5CDS-intronENST00000359831ENST00000462119TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
5CDS-intronENST00000368761ENST00000462119TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
5UTR-3CDSENST00000392556ENST00000358835TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
5UTR-3CDSENST00000392556ENST00000368802TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
5UTR-3CDSENST00000392556ENST00000368805TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
5UTR-3CDSENST00000392556ENST00000435970TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
5UTR-intronENST00000392556ENST00000462119TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
Frame-shiftENST00000359831ENST00000358835TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
Frame-shiftENST00000359831ENST00000368802TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
Frame-shiftENST00000359831ENST00000368805TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
Frame-shiftENST00000359831ENST00000435970TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
Frame-shiftENST00000368761ENST00000358835TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
Frame-shiftENST00000368761ENST00000368802TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
Frame-shiftENST00000368761ENST00000368805TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
Frame-shiftENST00000368761ENST00000435970TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
In-frameENST00000340026ENST00000358835TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
In-frameENST00000340026ENST00000368802TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
In-frameENST00000340026ENST00000368805TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
In-frameENST00000340026ENST00000435970TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
intron-3CDSENST00000368731ENST00000358835TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
intron-3CDSENST00000368731ENST00000368802TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
intron-3CDSENST00000368731ENST00000368805TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
intron-3CDSENST00000368731ENST00000435970TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
intron-3CDSENST00000368735ENST00000358835TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
intron-3CDSENST00000368735ENST00000368802TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
intron-3CDSENST00000368735ENST00000368805TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
intron-3CDSENST00000368735ENST00000435970TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
intron-intronENST00000368731ENST00000462119TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-
intron-intronENST00000368735ENST00000462119TRAF3IP2chr6

111901400

-REV3Lchr6

111654570

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340026TRAF3IP2chr6111901400-ENST00000368802REV3Lchr6111654570-4342164415813356591
ENST00000340026TRAF3IP2chr6111901400-ENST00000368805REV3Lchr6111654570-4342164415813356591
ENST00000340026TRAF3IP2chr6111901400-ENST00000435970REV3Lchr6111654570-4298164415813356591
ENST00000340026TRAF3IP2chr6111901400-ENST00000358835REV3Lchr6111654570-4298164415813356591

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340026ENST00000368802TRAF3IP2chr6111901400-REV3Lchr6111654570-0.0015559690.998444
ENST00000340026ENST00000368805TRAF3IP2chr6111901400-REV3Lchr6111654570-0.0015559690.998444
ENST00000340026ENST00000435970TRAF3IP2chr6111901400-REV3Lchr6111654570-0.0017517050.99824834
ENST00000340026ENST00000358835TRAF3IP2chr6111901400-REV3Lchr6111654570-0.0017517050.99824834

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Fusion Genomic Features for TRAF3IP2-REV3L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRAF3IP2-REV3L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111803953/chr6:111897024)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneREV3Lchr6:111901400chr6:111654570ENST0000035883522333086_310425603131.0MotifNote=CysB motif
TgeneREV3Lchr6:111901400chr6:111654570ENST0000036880221323086_310425603131.0MotifNote=CysB motif
TgeneREV3Lchr6:111901400chr6:111654570ENST0000036880522333086_310425603131.0MotifNote=CysB motif
TgeneREV3Lchr6:111901400chr6:111654570ENST0000043597023343086_310424823053.0MotifNote=CysB motif
TgeneREV3Lchr6:111901400chr6:111654570ENST0000035883522333042_305725603131.0Zinc fingerNote=CysA-type
TgeneREV3Lchr6:111901400chr6:111654570ENST0000036880221323042_305725603131.0Zinc fingerNote=CysA-type
TgeneREV3Lchr6:111901400chr6:111654570ENST0000036880522333042_305725603131.0Zinc fingerNote=CysA-type
TgeneREV3Lchr6:111901400chr6:111654570ENST0000043597023343042_305724823053.0Zinc fingerNote=CysA-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRAF3IP2chr6:111901400chr6:111654570ENST00000340026-410409_550349575.0DomainSEFIR
HgeneTRAF3IP2chr6:111901400chr6:111654570ENST00000359831-39409_550340565.0DomainSEFIR
HgeneTRAF3IP2chr6:111901400chr6:111654570ENST00000368735-14409_5500110.0DomainSEFIR
HgeneTRAF3IP2chr6:111901400chr6:111654570ENST00000368761-39409_550340566.0DomainSEFIR
HgeneTRAF3IP2chr6:111901400chr6:111654570ENST00000392556-410409_5500154.0DomainSEFIR


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Fusion Gene Sequence for TRAF3IP2-REV3L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93665_93665_1_TRAF3IP2-REV3L_TRAF3IP2_chr6_111901400_ENST00000340026_REV3L_chr6_111654570_ENST00000358835_length(transcript)=4298nt_BP=1644nt
CGGCAATGCTGATGTTTTAAGCAGTTAGAGGAGGTGGAAGAAGCTCGACTCCCTCTTCTTCCCCATTATCTGCCCACAATCCCCTCCTTT
GGAGCTGCTAATGATTACTAATTCTTAACATTCGAGTTCAATCTCCTCCCGGAGACACCCTCCCAGGCGAGGGCACTGCGACTACACTGA
GGTTCTGCCCACTCCTGGGCAGCTTCTTAGCTGGGTGGCGAAAACAAAAATGCCGCCTAATTGGTCACTGGCCCTTTCTCATGAATGAAG
GAGGTTTCTGTTTTAAGAAATAAAGTGACTCCTCAGCCGTTGATTCACTGCCCACAGGGAGATTTTGAGCAGAGGCTTCCTAGGCTCCGT
AGAAATTTGCATACAGCTTCCACTTCCTGCTTCAGAGCCTGTTCTTCTACTTACCTGGGCCCGGAGAAGGTGGAGGGAGACGAGAAGCCG
CCGAGAGCCGACTACCCTCCGGGCCCAGTCTGTCTGTCCGTGGTGGATCTAAGCCTCATCTGTATCCTCTTGTGATGGCGTGAAGGAAAG
CCATGGCAGATTTCCAGCCTGGTGATGCTGTACAGAACACAGGTGGCCTGCTTCCATGCCTCCTCAGCTTCAAGAAACTAGAATGAACCG
AAGCATTCCTGTGGAGGTTGATGAATCAGAACCATACCCAAGTCAGTTGCTGAAACCAATCCCAGAATATTCCCCGGAAGAGGAATCAGA
ACCACCTGCTCCAAATATAAGGAACATGGCACCCAACAGCTTGTCTGCACCCACAATGCTTCACAATTCCTCCGGAGACTTTTCTCAAGC
TCACTCAACCCTGAAACTTGCAAATCACCAGCGGCCTGTATCCCGGCAGGTCACCTGCCTGCGCACTCAAGTTCTGGAGGACAGTGAAGA
CAGTTTCTGCAGGAGACACCCAGGCCTGGGCAAAGCTTTCCCTTCTGGGTGCTCTGCAGTCAGCGAGCCTGCGTCTGAGTCTGTGGTTGG
AGCCCTCCCTGCAGAGCATCAGTTTTCATTTATGGAAAAACGTAATCAATGGCTGGTATCTCAGCTTTCAGCGGCTTCTCCTGACACTGG
CCATGACTCAGACAAATCAGACCAAAGTTTACCTAATGCCTCAGCAGACTCCTTGGGCGGTAGCCAGGAGATGGTGCAACGGCCCCAGCC
TCACAGGAACCGAGCAGGCCTGGATCTGCCAACCATAGACACGGGATATGATTCCCAGCCCCAGGATGTCCTGGGCATCAGGCAGCTGGA
AAGGCCCCTGCCCCTCACCTCCGTGTGTTACCCCCAGGACCTCCCCAGACCTCTCAGGTCCAGGGAGTTCCCTCAGTTTGAACCTCAGAG
GTATCCAGCATGTGCACAGATGCTGCCTCCCAATCTTTCCCCACATGCTCCATGGAACTATCATTACCATTGTCCTGGAAGTCCCGATCA
CCAGGTGCCATATGGCCATGACTACCCTCGAGCAGCCTACCAGCAAGTGATCCAGCCGGCTCTGCCTGGGCAGCCCCTGCCTGGAGCCAG
TGTGAGAGGCCTGCACCCTGTGCAGAAGGTTATCCTGAATTATCCCAGCCCCTGGGACCACGAAGAGAGGCCCGCACAGAGAGACTGCTC
CTTTCCGGGGCTTCCAAGGCACCATACCGTGTGGAATCAATGATGTTGCGTATTGCTAAACCAATGAACTATATTCCTGTGACACCTAGT
GTTCAGCAAAGATCCCAGATGAGAGCCCCACAGTGTGTTCCTCTAATTATGGAGCCTGAATCCCGCTTCTATAGCAACTCTGTTCTCGTT
TTGGATTTCCAATCACTTTATCCTTCTATTGTGATTGCATATAACTACTGCTTTTCCACCTGCCTTGGCCATGTGGAGAACTTGGGAAAG
TATGATGAGTTCAAATTTGGCTGTACCTCTCTGAGAGTACCTCCAGATTTACTTTACCAAGTTAGGCATGATATCACAGTGTCCCCCAAT
GGAGTAGCTTTTGTCAAGCCTTCAGTAAGAAAAGGTGTACTACCAAGAATGCTTGAAGAAATTTTGAAGACTAGATTTATGGTGAAGCAG
TCAATGAAGGCTTACAAGCAAGACAGAGCCCTGTCACGAATGCTTGATGCGCGTCAGTTGGGACTTAAGCTGATAGCAAATGTCACATTT
GGCTATACATCTGCTAATTTTTCTGGGAGAATGCCATGCATTGAGGTTGGCGATAGTATTGTTCACAAAGCCAGAGAGACCTTGGAACGA
GCTATTAAACTGGTGAATGATACCAAGAAATGGGGGGCTAGGGTTGTATATGGCGATACTGACAGTATGTTTGTGCTACTGAAAGGAGCC
ACTAAGGAGCAGTCTTTTAAGATTGGTCAGGAAATTGCCGAAGCTGTAACTGCTACCAATCCTAAACCAGTGAAATTGAAGTTTGAAAAG
GTATATTTGCCCTGTGTTTTACAAACAAAAAAGAGGTATGTGGGTTACATGTATGAAACACTGGATCAGAAGGACCCAGTATTTGATGCA
AAAGGAATAGAAACAGTCAGAAGAGATTCCTGCCCTGCTGTTTCTAAGATACTTGAGCGTTCTCTAAAGCTGCTATTTGAAACGAGAGAT
ATAAGTCTAATTAAACAGTATGTTCAGCGACAATGTATGAAGCTTCTGGAAGGAAAGGCCAGCATACAAGACTTTATCTTTGCCAAGGAA
TACAGAGGAAGTTTTTCTTATAAACCAGGAGCTTGTGTGCCAGCCCTTGAACTTACAAGGAAAATGCTGACTTATGACCGGCGCTCTGAG
CCTCAGGTTGGGGAGCGAGTGCCATACGTCATCATTTATGGGACCCCCGGAGTACCACTTATCCAGCTTGTAAGGCGCCCAGTGGAAGTC
CTGCAGGACCCAACTCTGAGACTGAATGCTACTTACTATATTACCAAGCAAATCCTTCCACCCTTGGCAAGAATCTTCTCACTTATTGGT
ATTGATGTCTTCAGCTGGTATCATGAATTACCAAGGATCCATAAAGCTACCAGCTCCTCGCGAAGTGAACCTGAAGGGCGGAAAGGCACT
ATTTCACAATATTTTACTACCTTACACTGTCCTGTGTGTGATGACCTAACTCAGCATGGCATCTGTAGTAAATGTCGGAGCCAACCTCAG
CATGTTGCAGTCATCCTCAACCAAGAAATCCGGGAGTTGGAACGTCAACAGGAGCAACTTGTAAAGATATGCAAGAACTGTACAGGTTGC
TTTGATCGACACATCCCATGTGTTTCTCTGAACTGCCCAGTACTTTTCAAACTCTCCCGAGTAAATAGAGAATTGTCCAAGGCACCATAT
CTCCGGCAGTTATTAGACCAGTTTTAAATTGTCAATATCACAGTATTACAGGTGCTATTTTTTTCAGTGCTTACCACTAAACTGTTGTGC
ATGGTGCTTTTTAACTTTCATCGAGTCAAGGATGTTCACTGTCTGTTATCTGAAGACTATGAAGACTTCTATGCTAACCGAATTAAAATG
TACTTGTTGATCTCTGAATAGCTCACTTCTTACAATGTACAAATTCCTCATTCTGTCACCTTTTAAACATTGTTTTATAATGCAGGTGTT
GGATTTGCTCCAGTATGTGTACCATCTTGTAAATTCATTTGAGTAGATCATGTTTACTTCCCAGTGGAAGGAGCACTGAAAACCTCTTAA
AGAAAAAGCATTTGTGTGTTTTCCTTGAACTGTCTGTATCAAGACGTGTTACTTCGAGATATCCATTCACTTTATAATTTTGACTGCAAA
ATATTTTGTAAATACACTTTTTTACTTTTCAAACGAGCAAAATAATGTGCAATGATTTTTATACAAATGATTTTCAAGTTGTTTGGTATA
TTTCCTCTAGGTTTTGCTTGACTCAAAGTAGATCGTTATTTTGATCAAACTGTGCAAACAGTAGTACCACGTGTAGCATTTTGAAACATT
ATTTTTTTTTAAAAAATGCTGTCTTGCTTTAGCTATTAATGGGGCATTGTGAGGAACTGTGCAAAGACATTTTTGTTACAAACCTGTGGG
CCTGTTGCAATACTTTAAAAATAAAAAATTTTATTCCATTTGCTTGTTTTGTATAGACATTTCTATTGCTTCTAAATATACTTAAAATAT
TTTCTTTCCTTATGTACTGTACAGTTAATCTTATTTGCCATCATCTTGAACACAAAATGTGTATTTAGAATATTTGTATAACTGTGTAAA

>93665_93665_1_TRAF3IP2-REV3L_TRAF3IP2_chr6_111901400_ENST00000340026_REV3L_chr6_111654570_ENST00000358835_length(amino acids)=591AA_BP=1
MGPRREARTERLLLSGASKAPYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYC
FSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDA
RQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVT
ATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLLE
GKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQ
ILPPLARIFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQPQHVAVILNQEIRELERQQ

--------------------------------------------------------------
>93665_93665_2_TRAF3IP2-REV3L_TRAF3IP2_chr6_111901400_ENST00000340026_REV3L_chr6_111654570_ENST00000368802_length(transcript)=4342nt_BP=1644nt
CGGCAATGCTGATGTTTTAAGCAGTTAGAGGAGGTGGAAGAAGCTCGACTCCCTCTTCTTCCCCATTATCTGCCCACAATCCCCTCCTTT
GGAGCTGCTAATGATTACTAATTCTTAACATTCGAGTTCAATCTCCTCCCGGAGACACCCTCCCAGGCGAGGGCACTGCGACTACACTGA
GGTTCTGCCCACTCCTGGGCAGCTTCTTAGCTGGGTGGCGAAAACAAAAATGCCGCCTAATTGGTCACTGGCCCTTTCTCATGAATGAAG
GAGGTTTCTGTTTTAAGAAATAAAGTGACTCCTCAGCCGTTGATTCACTGCCCACAGGGAGATTTTGAGCAGAGGCTTCCTAGGCTCCGT
AGAAATTTGCATACAGCTTCCACTTCCTGCTTCAGAGCCTGTTCTTCTACTTACCTGGGCCCGGAGAAGGTGGAGGGAGACGAGAAGCCG
CCGAGAGCCGACTACCCTCCGGGCCCAGTCTGTCTGTCCGTGGTGGATCTAAGCCTCATCTGTATCCTCTTGTGATGGCGTGAAGGAAAG
CCATGGCAGATTTCCAGCCTGGTGATGCTGTACAGAACACAGGTGGCCTGCTTCCATGCCTCCTCAGCTTCAAGAAACTAGAATGAACCG
AAGCATTCCTGTGGAGGTTGATGAATCAGAACCATACCCAAGTCAGTTGCTGAAACCAATCCCAGAATATTCCCCGGAAGAGGAATCAGA
ACCACCTGCTCCAAATATAAGGAACATGGCACCCAACAGCTTGTCTGCACCCACAATGCTTCACAATTCCTCCGGAGACTTTTCTCAAGC
TCACTCAACCCTGAAACTTGCAAATCACCAGCGGCCTGTATCCCGGCAGGTCACCTGCCTGCGCACTCAAGTTCTGGAGGACAGTGAAGA
CAGTTTCTGCAGGAGACACCCAGGCCTGGGCAAAGCTTTCCCTTCTGGGTGCTCTGCAGTCAGCGAGCCTGCGTCTGAGTCTGTGGTTGG
AGCCCTCCCTGCAGAGCATCAGTTTTCATTTATGGAAAAACGTAATCAATGGCTGGTATCTCAGCTTTCAGCGGCTTCTCCTGACACTGG
CCATGACTCAGACAAATCAGACCAAAGTTTACCTAATGCCTCAGCAGACTCCTTGGGCGGTAGCCAGGAGATGGTGCAACGGCCCCAGCC
TCACAGGAACCGAGCAGGCCTGGATCTGCCAACCATAGACACGGGATATGATTCCCAGCCCCAGGATGTCCTGGGCATCAGGCAGCTGGA
AAGGCCCCTGCCCCTCACCTCCGTGTGTTACCCCCAGGACCTCCCCAGACCTCTCAGGTCCAGGGAGTTCCCTCAGTTTGAACCTCAGAG
GTATCCAGCATGTGCACAGATGCTGCCTCCCAATCTTTCCCCACATGCTCCATGGAACTATCATTACCATTGTCCTGGAAGTCCCGATCA
CCAGGTGCCATATGGCCATGACTACCCTCGAGCAGCCTACCAGCAAGTGATCCAGCCGGCTCTGCCTGGGCAGCCCCTGCCTGGAGCCAG
TGTGAGAGGCCTGCACCCTGTGCAGAAGGTTATCCTGAATTATCCCAGCCCCTGGGACCACGAAGAGAGGCCCGCACAGAGAGACTGCTC
CTTTCCGGGGCTTCCAAGGCACCATACCGTGTGGAATCAATGATGTTGCGTATTGCTAAACCAATGAACTATATTCCTGTGACACCTAGT
GTTCAGCAAAGATCCCAGATGAGAGCCCCACAGTGTGTTCCTCTAATTATGGAGCCTGAATCCCGCTTCTATAGCAACTCTGTTCTCGTT
TTGGATTTCCAATCACTTTATCCTTCTATTGTGATTGCATATAACTACTGCTTTTCCACCTGCCTTGGCCATGTGGAGAACTTGGGAAAG
TATGATGAGTTCAAATTTGGCTGTACCTCTCTGAGAGTACCTCCAGATTTACTTTACCAAGTTAGGCATGATATCACAGTGTCCCCCAAT
GGAGTAGCTTTTGTCAAGCCTTCAGTAAGAAAAGGTGTACTACCAAGAATGCTTGAAGAAATTTTGAAGACTAGATTTATGGTGAAGCAG
TCAATGAAGGCTTACAAGCAAGACAGAGCCCTGTCACGAATGCTTGATGCGCGTCAGTTGGGACTTAAGCTGATAGCAAATGTCACATTT
GGCTATACATCTGCTAATTTTTCTGGGAGAATGCCATGCATTGAGGTTGGCGATAGTATTGTTCACAAAGCCAGAGAGACCTTGGAACGA
GCTATTAAACTGGTGAATGATACCAAGAAATGGGGGGCTAGGGTTGTATATGGCGATACTGACAGTATGTTTGTGCTACTGAAAGGAGCC
ACTAAGGAGCAGTCTTTTAAGATTGGTCAGGAAATTGCCGAAGCTGTAACTGCTACCAATCCTAAACCAGTGAAATTGAAGTTTGAAAAG
GTATATTTGCCCTGTGTTTTACAAACAAAAAAGAGGTATGTGGGTTACATGTATGAAACACTGGATCAGAAGGACCCAGTATTTGATGCA
AAAGGAATAGAAACAGTCAGAAGAGATTCCTGCCCTGCTGTTTCTAAGATACTTGAGCGTTCTCTAAAGCTGCTATTTGAAACGAGAGAT
ATAAGTCTAATTAAACAGTATGTTCAGCGACAATGTATGAAGCTTCTGGAAGGAAAGGCCAGCATACAAGACTTTATCTTTGCCAAGGAA
TACAGAGGAAGTTTTTCTTATAAACCAGGAGCTTGTGTGCCAGCCCTTGAACTTACAAGGAAAATGCTGACTTATGACCGGCGCTCTGAG
CCTCAGGTTGGGGAGCGAGTGCCATACGTCATCATTTATGGGACCCCCGGAGTACCACTTATCCAGCTTGTAAGGCGCCCAGTGGAAGTC
CTGCAGGACCCAACTCTGAGACTGAATGCTACTTACTATATTACCAAGCAAATCCTTCCACCCTTGGCAAGAATCTTCTCACTTATTGGT
ATTGATGTCTTCAGCTGGTATCATGAATTACCAAGGATCCATAAAGCTACCAGCTCCTCGCGAAGTGAACCTGAAGGGCGGAAAGGCACT
ATTTCACAATATTTTACTACCTTACACTGTCCTGTGTGTGATGACCTAACTCAGCATGGCATCTGTAGTAAATGTCGGAGCCAACCTCAG
CATGTTGCAGTCATCCTCAACCAAGAAATCCGGGAGTTGGAACGTCAACAGGAGCAACTTGTAAAGATATGCAAGAACTGTACAGGTTGC
TTTGATCGACACATCCCATGTGTTTCTCTGAACTGCCCAGTACTTTTCAAACTCTCCCGAGTAAATAGAGAATTGTCCAAGGCACCATAT
CTCCGGCAGTTATTAGACCAGTTTTAAATTGTCAATATCACAGTATTACAGGTGCTATTTTTTTCAGTGCTTACCACTAAACTGTTGTGC
ATGGTGCTTTTTAACTTTCATCGAGTCAAGGATGTTCACTGTCTGTTATCTGAAGACTATGAAGACTTCTATGCTAACCGAATTAAAATG
TACTTGTTGATCTCTGAATAGCTCACTTCTTACAATGTACAAATTCCTCATTCTGTCACCTTTTAAACATTGTTTTATAATGCAGGTGTT
GGATTTGCTCCAGTATGTGTACCATCTTGTAAATTCATTTGAGTAGATCATGTTTACTTCCCAGTGGAAGGAGCACTGAAAACCTCTTAA
AGAAAAAGCATTTGTGTGTTTTCCTTGAACTGTCTGTATCAAGACGTGTTACTTCGAGATATCCATTCACTTTATAATTTTGACTGCAAA
ATATTTTGTAAATACACTTTTTTACTTTTCAAACGAGCAAAATAATGTGCAATGATTTTTATACAAATGATTTTCAAGTTGTTTGGTATA
TTTCCTCTAGGTTTTGCTTGACTCAAAGTAGATCGTTATTTTGATCAAACTGTGCAAACAGTAGTACCACGTGTAGCATTTTGAAACATT
ATTTTTTTTTAAAAAATGCTGTCTTGCTTTAGCTATTAATGGGGCATTGTGAGGAACTGTGCAAAGACATTTTTGTTACAAACCTGTGGG
CCTGTTGCAATACTTTAAAAATAAAAAATTTTATTCCATTTGCTTGTTTTGTATAGACATTTCTATTGCTTCTAAATATACTTAAAATAT
TTTCTTTCCTTATGTACTGTACAGTTAATCTTATTTGCCATCATCTTGAACACAAAATGTGTATTTAGAATATTTGTATAACTGTGTAAA
ATAAAAAAGGAATTATGTGGTCAGTGCATTGTTTTTTAAACTGGAAATCATTTTGTTTTAAAAGTTAATAATGGAAACCATATTAAAATT

>93665_93665_2_TRAF3IP2-REV3L_TRAF3IP2_chr6_111901400_ENST00000340026_REV3L_chr6_111654570_ENST00000368802_length(amino acids)=591AA_BP=1
MGPRREARTERLLLSGASKAPYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYC
FSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDA
RQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVT
ATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLLE
GKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQ
ILPPLARIFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQPQHVAVILNQEIRELERQQ

--------------------------------------------------------------
>93665_93665_3_TRAF3IP2-REV3L_TRAF3IP2_chr6_111901400_ENST00000340026_REV3L_chr6_111654570_ENST00000368805_length(transcript)=4342nt_BP=1644nt
CGGCAATGCTGATGTTTTAAGCAGTTAGAGGAGGTGGAAGAAGCTCGACTCCCTCTTCTTCCCCATTATCTGCCCACAATCCCCTCCTTT
GGAGCTGCTAATGATTACTAATTCTTAACATTCGAGTTCAATCTCCTCCCGGAGACACCCTCCCAGGCGAGGGCACTGCGACTACACTGA
GGTTCTGCCCACTCCTGGGCAGCTTCTTAGCTGGGTGGCGAAAACAAAAATGCCGCCTAATTGGTCACTGGCCCTTTCTCATGAATGAAG
GAGGTTTCTGTTTTAAGAAATAAAGTGACTCCTCAGCCGTTGATTCACTGCCCACAGGGAGATTTTGAGCAGAGGCTTCCTAGGCTCCGT
AGAAATTTGCATACAGCTTCCACTTCCTGCTTCAGAGCCTGTTCTTCTACTTACCTGGGCCCGGAGAAGGTGGAGGGAGACGAGAAGCCG
CCGAGAGCCGACTACCCTCCGGGCCCAGTCTGTCTGTCCGTGGTGGATCTAAGCCTCATCTGTATCCTCTTGTGATGGCGTGAAGGAAAG
CCATGGCAGATTTCCAGCCTGGTGATGCTGTACAGAACACAGGTGGCCTGCTTCCATGCCTCCTCAGCTTCAAGAAACTAGAATGAACCG
AAGCATTCCTGTGGAGGTTGATGAATCAGAACCATACCCAAGTCAGTTGCTGAAACCAATCCCAGAATATTCCCCGGAAGAGGAATCAGA
ACCACCTGCTCCAAATATAAGGAACATGGCACCCAACAGCTTGTCTGCACCCACAATGCTTCACAATTCCTCCGGAGACTTTTCTCAAGC
TCACTCAACCCTGAAACTTGCAAATCACCAGCGGCCTGTATCCCGGCAGGTCACCTGCCTGCGCACTCAAGTTCTGGAGGACAGTGAAGA
CAGTTTCTGCAGGAGACACCCAGGCCTGGGCAAAGCTTTCCCTTCTGGGTGCTCTGCAGTCAGCGAGCCTGCGTCTGAGTCTGTGGTTGG
AGCCCTCCCTGCAGAGCATCAGTTTTCATTTATGGAAAAACGTAATCAATGGCTGGTATCTCAGCTTTCAGCGGCTTCTCCTGACACTGG
CCATGACTCAGACAAATCAGACCAAAGTTTACCTAATGCCTCAGCAGACTCCTTGGGCGGTAGCCAGGAGATGGTGCAACGGCCCCAGCC
TCACAGGAACCGAGCAGGCCTGGATCTGCCAACCATAGACACGGGATATGATTCCCAGCCCCAGGATGTCCTGGGCATCAGGCAGCTGGA
AAGGCCCCTGCCCCTCACCTCCGTGTGTTACCCCCAGGACCTCCCCAGACCTCTCAGGTCCAGGGAGTTCCCTCAGTTTGAACCTCAGAG
GTATCCAGCATGTGCACAGATGCTGCCTCCCAATCTTTCCCCACATGCTCCATGGAACTATCATTACCATTGTCCTGGAAGTCCCGATCA
CCAGGTGCCATATGGCCATGACTACCCTCGAGCAGCCTACCAGCAAGTGATCCAGCCGGCTCTGCCTGGGCAGCCCCTGCCTGGAGCCAG
TGTGAGAGGCCTGCACCCTGTGCAGAAGGTTATCCTGAATTATCCCAGCCCCTGGGACCACGAAGAGAGGCCCGCACAGAGAGACTGCTC
CTTTCCGGGGCTTCCAAGGCACCATACCGTGTGGAATCAATGATGTTGCGTATTGCTAAACCAATGAACTATATTCCTGTGACACCTAGT
GTTCAGCAAAGATCCCAGATGAGAGCCCCACAGTGTGTTCCTCTAATTATGGAGCCTGAATCCCGCTTCTATAGCAACTCTGTTCTCGTT
TTGGATTTCCAATCACTTTATCCTTCTATTGTGATTGCATATAACTACTGCTTTTCCACCTGCCTTGGCCATGTGGAGAACTTGGGAAAG
TATGATGAGTTCAAATTTGGCTGTACCTCTCTGAGAGTACCTCCAGATTTACTTTACCAAGTTAGGCATGATATCACAGTGTCCCCCAAT
GGAGTAGCTTTTGTCAAGCCTTCAGTAAGAAAAGGTGTACTACCAAGAATGCTTGAAGAAATTTTGAAGACTAGATTTATGGTGAAGCAG
TCAATGAAGGCTTACAAGCAAGACAGAGCCCTGTCACGAATGCTTGATGCGCGTCAGTTGGGACTTAAGCTGATAGCAAATGTCACATTT
GGCTATACATCTGCTAATTTTTCTGGGAGAATGCCATGCATTGAGGTTGGCGATAGTATTGTTCACAAAGCCAGAGAGACCTTGGAACGA
GCTATTAAACTGGTGAATGATACCAAGAAATGGGGGGCTAGGGTTGTATATGGCGATACTGACAGTATGTTTGTGCTACTGAAAGGAGCC
ACTAAGGAGCAGTCTTTTAAGATTGGTCAGGAAATTGCCGAAGCTGTAACTGCTACCAATCCTAAACCAGTGAAATTGAAGTTTGAAAAG
GTATATTTGCCCTGTGTTTTACAAACAAAAAAGAGGTATGTGGGTTACATGTATGAAACACTGGATCAGAAGGACCCAGTATTTGATGCA
AAAGGAATAGAAACAGTCAGAAGAGATTCCTGCCCTGCTGTTTCTAAGATACTTGAGCGTTCTCTAAAGCTGCTATTTGAAACGAGAGAT
ATAAGTCTAATTAAACAGTATGTTCAGCGACAATGTATGAAGCTTCTGGAAGGAAAGGCCAGCATACAAGACTTTATCTTTGCCAAGGAA
TACAGAGGAAGTTTTTCTTATAAACCAGGAGCTTGTGTGCCAGCCCTTGAACTTACAAGGAAAATGCTGACTTATGACCGGCGCTCTGAG
CCTCAGGTTGGGGAGCGAGTGCCATACGTCATCATTTATGGGACCCCCGGAGTACCACTTATCCAGCTTGTAAGGCGCCCAGTGGAAGTC
CTGCAGGACCCAACTCTGAGACTGAATGCTACTTACTATATTACCAAGCAAATCCTTCCACCCTTGGCAAGAATCTTCTCACTTATTGGT
ATTGATGTCTTCAGCTGGTATCATGAATTACCAAGGATCCATAAAGCTACCAGCTCCTCGCGAAGTGAACCTGAAGGGCGGAAAGGCACT
ATTTCACAATATTTTACTACCTTACACTGTCCTGTGTGTGATGACCTAACTCAGCATGGCATCTGTAGTAAATGTCGGAGCCAACCTCAG
CATGTTGCAGTCATCCTCAACCAAGAAATCCGGGAGTTGGAACGTCAACAGGAGCAACTTGTAAAGATATGCAAGAACTGTACAGGTTGC
TTTGATCGACACATCCCATGTGTTTCTCTGAACTGCCCAGTACTTTTCAAACTCTCCCGAGTAAATAGAGAATTGTCCAAGGCACCATAT
CTCCGGCAGTTATTAGACCAGTTTTAAATTGTCAATATCACAGTATTACAGGTGCTATTTTTTTCAGTGCTTACCACTAAACTGTTGTGC
ATGGTGCTTTTTAACTTTCATCGAGTCAAGGATGTTCACTGTCTGTTATCTGAAGACTATGAAGACTTCTATGCTAACCGAATTAAAATG
TACTTGTTGATCTCTGAATAGCTCACTTCTTACAATGTACAAATTCCTCATTCTGTCACCTTTTAAACATTGTTTTATAATGCAGGTGTT
GGATTTGCTCCAGTATGTGTACCATCTTGTAAATTCATTTGAGTAGATCATGTTTACTTCCCAGTGGAAGGAGCACTGAAAACCTCTTAA
AGAAAAAGCATTTGTGTGTTTTCCTTGAACTGTCTGTATCAAGACGTGTTACTTCGAGATATCCATTCACTTTATAATTTTGACTGCAAA
ATATTTTGTAAATACACTTTTTTACTTTTCAAACGAGCAAAATAATGTGCAATGATTTTTATACAAATGATTTTCAAGTTGTTTGGTATA
TTTCCTCTAGGTTTTGCTTGACTCAAAGTAGATCGTTATTTTGATCAAACTGTGCAAACAGTAGTACCACGTGTAGCATTTTGAAACATT
ATTTTTTTTTAAAAAATGCTGTCTTGCTTTAGCTATTAATGGGGCATTGTGAGGAACTGTGCAAAGACATTTTTGTTACAAACCTGTGGG
CCTGTTGCAATACTTTAAAAATAAAAAATTTTATTCCATTTGCTTGTTTTGTATAGACATTTCTATTGCTTCTAAATATACTTAAAATAT
TTTCTTTCCTTATGTACTGTACAGTTAATCTTATTTGCCATCATCTTGAACACAAAATGTGTATTTAGAATATTTGTATAACTGTGTAAA
ATAAAAAAGGAATTATGTGGTCAGTGCATTGTTTTTTAAACTGGAAATCATTTTGTTTTAAAAGTTAATAATGGAAACCATATTAAAATT

>93665_93665_3_TRAF3IP2-REV3L_TRAF3IP2_chr6_111901400_ENST00000340026_REV3L_chr6_111654570_ENST00000368805_length(amino acids)=591AA_BP=1
MGPRREARTERLLLSGASKAPYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYC
FSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDA
RQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVT
ATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLLE
GKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQ
ILPPLARIFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQPQHVAVILNQEIRELERQQ

--------------------------------------------------------------
>93665_93665_4_TRAF3IP2-REV3L_TRAF3IP2_chr6_111901400_ENST00000340026_REV3L_chr6_111654570_ENST00000435970_length(transcript)=4298nt_BP=1644nt
CGGCAATGCTGATGTTTTAAGCAGTTAGAGGAGGTGGAAGAAGCTCGACTCCCTCTTCTTCCCCATTATCTGCCCACAATCCCCTCCTTT
GGAGCTGCTAATGATTACTAATTCTTAACATTCGAGTTCAATCTCCTCCCGGAGACACCCTCCCAGGCGAGGGCACTGCGACTACACTGA
GGTTCTGCCCACTCCTGGGCAGCTTCTTAGCTGGGTGGCGAAAACAAAAATGCCGCCTAATTGGTCACTGGCCCTTTCTCATGAATGAAG
GAGGTTTCTGTTTTAAGAAATAAAGTGACTCCTCAGCCGTTGATTCACTGCCCACAGGGAGATTTTGAGCAGAGGCTTCCTAGGCTCCGT
AGAAATTTGCATACAGCTTCCACTTCCTGCTTCAGAGCCTGTTCTTCTACTTACCTGGGCCCGGAGAAGGTGGAGGGAGACGAGAAGCCG
CCGAGAGCCGACTACCCTCCGGGCCCAGTCTGTCTGTCCGTGGTGGATCTAAGCCTCATCTGTATCCTCTTGTGATGGCGTGAAGGAAAG
CCATGGCAGATTTCCAGCCTGGTGATGCTGTACAGAACACAGGTGGCCTGCTTCCATGCCTCCTCAGCTTCAAGAAACTAGAATGAACCG
AAGCATTCCTGTGGAGGTTGATGAATCAGAACCATACCCAAGTCAGTTGCTGAAACCAATCCCAGAATATTCCCCGGAAGAGGAATCAGA
ACCACCTGCTCCAAATATAAGGAACATGGCACCCAACAGCTTGTCTGCACCCACAATGCTTCACAATTCCTCCGGAGACTTTTCTCAAGC
TCACTCAACCCTGAAACTTGCAAATCACCAGCGGCCTGTATCCCGGCAGGTCACCTGCCTGCGCACTCAAGTTCTGGAGGACAGTGAAGA
CAGTTTCTGCAGGAGACACCCAGGCCTGGGCAAAGCTTTCCCTTCTGGGTGCTCTGCAGTCAGCGAGCCTGCGTCTGAGTCTGTGGTTGG
AGCCCTCCCTGCAGAGCATCAGTTTTCATTTATGGAAAAACGTAATCAATGGCTGGTATCTCAGCTTTCAGCGGCTTCTCCTGACACTGG
CCATGACTCAGACAAATCAGACCAAAGTTTACCTAATGCCTCAGCAGACTCCTTGGGCGGTAGCCAGGAGATGGTGCAACGGCCCCAGCC
TCACAGGAACCGAGCAGGCCTGGATCTGCCAACCATAGACACGGGATATGATTCCCAGCCCCAGGATGTCCTGGGCATCAGGCAGCTGGA
AAGGCCCCTGCCCCTCACCTCCGTGTGTTACCCCCAGGACCTCCCCAGACCTCTCAGGTCCAGGGAGTTCCCTCAGTTTGAACCTCAGAG
GTATCCAGCATGTGCACAGATGCTGCCTCCCAATCTTTCCCCACATGCTCCATGGAACTATCATTACCATTGTCCTGGAAGTCCCGATCA
CCAGGTGCCATATGGCCATGACTACCCTCGAGCAGCCTACCAGCAAGTGATCCAGCCGGCTCTGCCTGGGCAGCCCCTGCCTGGAGCCAG
TGTGAGAGGCCTGCACCCTGTGCAGAAGGTTATCCTGAATTATCCCAGCCCCTGGGACCACGAAGAGAGGCCCGCACAGAGAGACTGCTC
CTTTCCGGGGCTTCCAAGGCACCATACCGTGTGGAATCAATGATGTTGCGTATTGCTAAACCAATGAACTATATTCCTGTGACACCTAGT
GTTCAGCAAAGATCCCAGATGAGAGCCCCACAGTGTGTTCCTCTAATTATGGAGCCTGAATCCCGCTTCTATAGCAACTCTGTTCTCGTT
TTGGATTTCCAATCACTTTATCCTTCTATTGTGATTGCATATAACTACTGCTTTTCCACCTGCCTTGGCCATGTGGAGAACTTGGGAAAG
TATGATGAGTTCAAATTTGGCTGTACCTCTCTGAGAGTACCTCCAGATTTACTTTACCAAGTTAGGCATGATATCACAGTGTCCCCCAAT
GGAGTAGCTTTTGTCAAGCCTTCAGTAAGAAAAGGTGTACTACCAAGAATGCTTGAAGAAATTTTGAAGACTAGATTTATGGTGAAGCAG
TCAATGAAGGCTTACAAGCAAGACAGAGCCCTGTCACGAATGCTTGATGCGCGTCAGTTGGGACTTAAGCTGATAGCAAATGTCACATTT
GGCTATACATCTGCTAATTTTTCTGGGAGAATGCCATGCATTGAGGTTGGCGATAGTATTGTTCACAAAGCCAGAGAGACCTTGGAACGA
GCTATTAAACTGGTGAATGATACCAAGAAATGGGGGGCTAGGGTTGTATATGGCGATACTGACAGTATGTTTGTGCTACTGAAAGGAGCC
ACTAAGGAGCAGTCTTTTAAGATTGGTCAGGAAATTGCCGAAGCTGTAACTGCTACCAATCCTAAACCAGTGAAATTGAAGTTTGAAAAG
GTATATTTGCCCTGTGTTTTACAAACAAAAAAGAGGTATGTGGGTTACATGTATGAAACACTGGATCAGAAGGACCCAGTATTTGATGCA
AAAGGAATAGAAACAGTCAGAAGAGATTCCTGCCCTGCTGTTTCTAAGATACTTGAGCGTTCTCTAAAGCTGCTATTTGAAACGAGAGAT
ATAAGTCTAATTAAACAGTATGTTCAGCGACAATGTATGAAGCTTCTGGAAGGAAAGGCCAGCATACAAGACTTTATCTTTGCCAAGGAA
TACAGAGGAAGTTTTTCTTATAAACCAGGAGCTTGTGTGCCAGCCCTTGAACTTACAAGGAAAATGCTGACTTATGACCGGCGCTCTGAG
CCTCAGGTTGGGGAGCGAGTGCCATACGTCATCATTTATGGGACCCCCGGAGTACCACTTATCCAGCTTGTAAGGCGCCCAGTGGAAGTC
CTGCAGGACCCAACTCTGAGACTGAATGCTACTTACTATATTACCAAGCAAATCCTTCCACCCTTGGCAAGAATCTTCTCACTTATTGGT
ATTGATGTCTTCAGCTGGTATCATGAATTACCAAGGATCCATAAAGCTACCAGCTCCTCGCGAAGTGAACCTGAAGGGCGGAAAGGCACT
ATTTCACAATATTTTACTACCTTACACTGTCCTGTGTGTGATGACCTAACTCAGCATGGCATCTGTAGTAAATGTCGGAGCCAACCTCAG
CATGTTGCAGTCATCCTCAACCAAGAAATCCGGGAGTTGGAACGTCAACAGGAGCAACTTGTAAAGATATGCAAGAACTGTACAGGTTGC
TTTGATCGACACATCCCATGTGTTTCTCTGAACTGCCCAGTACTTTTCAAACTCTCCCGAGTAAATAGAGAATTGTCCAAGGCACCATAT
CTCCGGCAGTTATTAGACCAGTTTTAAATTGTCAATATCACAGTATTACAGGTGCTATTTTTTTCAGTGCTTACCACTAAACTGTTGTGC
ATGGTGCTTTTTAACTTTCATCGAGTCAAGGATGTTCACTGTCTGTTATCTGAAGACTATGAAGACTTCTATGCTAACCGAATTAAAATG
TACTTGTTGATCTCTGAATAGCTCACTTCTTACAATGTACAAATTCCTCATTCTGTCACCTTTTAAACATTGTTTTATAATGCAGGTGTT
GGATTTGCTCCAGTATGTGTACCATCTTGTAAATTCATTTGAGTAGATCATGTTTACTTCCCAGTGGAAGGAGCACTGAAAACCTCTTAA
AGAAAAAGCATTTGTGTGTTTTCCTTGAACTGTCTGTATCAAGACGTGTTACTTCGAGATATCCATTCACTTTATAATTTTGACTGCAAA
ATATTTTGTAAATACACTTTTTTACTTTTCAAACGAGCAAAATAATGTGCAATGATTTTTATACAAATGATTTTCAAGTTGTTTGGTATA
TTTCCTCTAGGTTTTGCTTGACTCAAAGTAGATCGTTATTTTGATCAAACTGTGCAAACAGTAGTACCACGTGTAGCATTTTGAAACATT
ATTTTTTTTTAAAAAATGCTGTCTTGCTTTAGCTATTAATGGGGCATTGTGAGGAACTGTGCAAAGACATTTTTGTTACAAACCTGTGGG
CCTGTTGCAATACTTTAAAAATAAAAAATTTTATTCCATTTGCTTGTTTTGTATAGACATTTCTATTGCTTCTAAATATACTTAAAATAT
TTTCTTTCCTTATGTACTGTACAGTTAATCTTATTTGCCATCATCTTGAACACAAAATGTGTATTTAGAATATTTGTATAACTGTGTAAA

>93665_93665_4_TRAF3IP2-REV3L_TRAF3IP2_chr6_111901400_ENST00000340026_REV3L_chr6_111654570_ENST00000435970_length(amino acids)=591AA_BP=1
MGPRREARTERLLLSGASKAPYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYC
FSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDA
RQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVT
ATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLLE
GKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQ
ILPPLARIFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQPQHVAVILNQEIRELERQQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRAF3IP2-REV3L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRAF3IP2-REV3L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRAF3IP2-REV3L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource