FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TRAF3-MARK3 (FusionGDB2 ID:93670)

Fusion Gene Summary for TRAF3-MARK3

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAF3-MARK3
Fusion gene ID: 93670
HgeneTgene
Gene symbol

TRAF3

MARK3

Gene ID

7187

4140

Gene nameTNF receptor associated factor 3microtubule affinity regulating kinase 3
SynonymsCAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118CTAK1|KP78|PAR1A|Par-1a|VIPB
Cytomap

14q32.32

14q32.32-q32.33

Type of geneprotein-codingprotein-coding
DescriptionTNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3MAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78
Modification date2020032720200313
UniProtAcc

Q13114

P27448

Ensembl transtripts involved in fusion geneENST00000347662, ENST00000351691, 
ENST00000392745, ENST00000539721, 
ENST00000560371, 		ENST00000216288, 
ENST00000303622, ENST00000335102, 
ENST00000416682, ENST00000429436, 
ENST00000440884, ENST00000553942, 
ENST00000561071, 
Fusion gene scores* DoF score15 X 11 X 11=181516 X 19 X 9=2736
# samples 2021
** MAII scorelog2(20/1815*10)=-3.18189764310839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2736*10)=-3.70360699721978
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRAF3 [Title/Abstract] AND MARK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMARK3(103928798)-TRAF3(103336522), # samples:1
TRAF3(103296809)-MARK3(103894724), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMARK3

GO:0018105

peptidyl-serine phosphorylation

9543386

TgeneMARK3

GO:0032092

positive regulation of protein binding

9543386

TgeneMARK3

GO:0035331

negative regulation of hippo signaling

28087714

TgeneMARK3

GO:0036289

peptidyl-serine autophosphorylation

9543386


check buttonFusion gene breakpoints across TRAF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MARK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B8-A54J-01ATRAF3chr14

103296809

+MARK3chr14

103894724

+


Top

Fusion Gene ORF analysis for TRAF3-MARK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000347662ENST00000216288TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000347662ENST00000303622TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000347662ENST00000335102TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000347662ENST00000416682TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000347662ENST00000429436TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000347662ENST00000440884TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000347662ENST00000553942TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000351691ENST00000216288TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000351691ENST00000303622TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000351691ENST00000335102TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000351691ENST00000416682TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000351691ENST00000429436TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000351691ENST00000440884TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000351691ENST00000553942TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000392745ENST00000216288TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000392745ENST00000303622TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000392745ENST00000335102TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000392745ENST00000416682TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000392745ENST00000429436TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000392745ENST00000440884TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3CDSENST00000392745ENST00000553942TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3UTRENST00000347662ENST00000561071TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3UTRENST00000351691ENST00000561071TRAF3chr14

103296809

+MARK3chr14

103894724

+
5UTR-3UTRENST00000392745ENST00000561071TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000539721ENST00000216288TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000539721ENST00000303622TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000539721ENST00000335102TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000539721ENST00000416682TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000539721ENST00000429436TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000539721ENST00000440884TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000539721ENST00000553942TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000560371ENST00000216288TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000560371ENST00000303622TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000560371ENST00000335102TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000560371ENST00000416682TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000560371ENST00000429436TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000560371ENST00000440884TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3CDSENST00000560371ENST00000553942TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3UTRENST00000539721ENST00000561071TRAF3chr14

103296809

+MARK3chr14

103894724

+
intron-3UTRENST00000560371ENST00000561071TRAF3chr14

103296809

+MARK3chr14

103894724

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for TRAF3-MARK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRAF3chr14103296809+MARK3chr14103894723+0.0038896310.9961104
TRAF3chr14103296809+MARK3chr14103894723+0.0038896310.9961104

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for TRAF3-MARK3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:103928798/:103336522)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAF3

Q13114

MARK3

P27448

FUNCTION: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819, ECO:0000269|PubMed:32562145}.FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). {ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for TRAF3-MARK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for TRAF3-MARK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TRAF3-MARK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TRAF3-MARK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource