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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRAP1-ADCY9 (FusionGDB2 ID:93755)

Fusion Gene Summary for TRAP1-ADCY9

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAP1-ADCY9
Fusion gene ID: 93755
HgeneTgene
Gene symbol

TRAP1

ADCY9

Gene ID

10131

115

Gene nameTNF receptor associated protein 1adenylate cyclase 9
SynonymsHSP 75|HSP75|HSP90L|TRAP-1AC9|ACIX
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein 75 kDa, mitochondrialTNFR-associated protein 1testicular tissue protein Li 209tumor necrosis factor type 1 receptor-associated proteinadenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyase
Modification date2020031320200313
UniProtAcc.

O60503

Ensembl transtripts involved in fusion geneENST00000246957, ENST00000538171, 
ENST00000575671, ENST00000573872, 
ENST00000571889, ENST00000294016, 
Fusion gene scores* DoF score6 X 6 X 4=1448 X 7 X 6=336
# samples 69
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRAP1 [Title/Abstract] AND ADCY9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRAP1(3721723)-ADCY9(4029276), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADCY9

GO:0006171

cAMP biosynthetic process

9628827|10987815

TgeneADCY9

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

9628827


check buttonFusion gene breakpoints across TRAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADCY9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1NE-01ATRAP1chr16

3721723

-ADCY9chr16

4029276

-


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Fusion Gene ORF analysis for TRAP1-ADCY9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000246957ENST00000571889TRAP1chr16

3721723

-ADCY9chr16

4029276

-
5CDS-intronENST00000538171ENST00000571889TRAP1chr16

3721723

-ADCY9chr16

4029276

-
5CDS-intronENST00000575671ENST00000571889TRAP1chr16

3721723

-ADCY9chr16

4029276

-
5UTR-3CDSENST00000573872ENST00000294016TRAP1chr16

3721723

-ADCY9chr16

4029276

-
5UTR-intronENST00000573872ENST00000571889TRAP1chr16

3721723

-ADCY9chr16

4029276

-
In-frameENST00000246957ENST00000294016TRAP1chr16

3721723

-ADCY9chr16

4029276

-
In-frameENST00000538171ENST00000294016TRAP1chr16

3721723

-ADCY9chr16

4029276

-
In-frameENST00000575671ENST00000294016TRAP1chr16

3721723

-ADCY9chr16

4029276

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000246957TRAP1chr163721723-ENST00000294016ADCY9chr164029276-59911324622866934
ENST00000575671TRAP1chr163721723-ENST00000294016ADCY9chr164029276-600513386282880750
ENST00000538171TRAP1chr163721723-ENST00000294016ADCY9chr164029276-5748108152623872

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000246957ENST00000294016TRAP1chr163721723-ADCY9chr164029276-0.000885020.99911493
ENST00000575671ENST00000294016TRAP1chr163721723-ADCY9chr164029276-0.0014604350.99853957
ENST00000538171ENST00000294016TRAP1chr163721723-ADCY9chr164029276-0.0011334170.99886656

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Fusion Genomic Features for TRAP1-ADCY9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRAP1-ADCY9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:3721723/chr16:4029276)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADCY9

O60503

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADCY9chr16:3721723chr16:4029276ENST000002940166111058_11988391354.0DomainGuanylate cyclase 2
TgeneADCY9chr16:3721723chr16:4029276ENST000002940166111185_11878391354.0Nucleotide bindingATP
TgeneADCY9chr16:3721723chr16:4029276ENST000002940166111192_11968391354.0Nucleotide bindingATP
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611840_8678391354.0Topological domainCytoplasmic
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611889_8918391354.0Topological domainExtracellular
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611913_9208391354.0Topological domainCytoplasmic
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611942_9758391354.0Topological domainExtracellular
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611997_13538391354.0Topological domainCytoplasmic
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611868_8888391354.0TransmembraneHelical
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611892_9128391354.0TransmembraneHelical
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611921_9418391354.0TransmembraneHelical
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611976_9968391354.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611394_5218391354.0DomainGuanylate cyclase 1
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611399_4048391354.0Nucleotide bindingATP
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611441_4438391354.0Nucleotide bindingATP
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611139_1418391354.0Topological domainExtracellular
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611163_1718391354.0Topological domainCytoplasmic
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611193_2158391354.0Topological domainExtracellular
TgeneADCY9chr16:3721723chr16:4029276ENST000002940166111_1178391354.0Topological domainCytoplasmic
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611236_2418391354.0Topological domainCytoplasmic
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611260_2808391354.0Topological domainExtracellular
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611302_7868391354.0Topological domainCytoplasmic
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611808_8188391354.0Topological domainExtracellular
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611118_1388391354.0TransmembraneHelical
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611142_1628391354.0TransmembraneHelical
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611172_1928391354.0TransmembraneHelical
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611216_2358391354.0TransmembraneHelical
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611242_2598391354.0TransmembraneHelical
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611281_3018391354.0TransmembraneHelical
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611787_8078391354.0TransmembraneHelical
TgeneADCY9chr16:3721723chr16:4029276ENST00000294016611819_8398391354.0TransmembraneHelical


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Fusion Gene Sequence for TRAP1-ADCY9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93755_93755_1_TRAP1-ADCY9_TRAP1_chr16_3721723_ENST00000246957_ADCY9_chr16_4029276_ENST00000294016_length(transcript)=5991nt_BP=1324nt
GAGGAAGCCCCGCCCCGCGCAGCCCCGTCCCGCCCCTTCCCATCGTGTACGGTCCCGCGTGGCTGCGCGCGGCGCTCTGGGAGTACGACA
TGGCGCGCGAGCTGCGGGCGCTGCTGCTGTGGGGCCGCCGCCTGCGGCCTTTGCTGCGGGCGCCGGCGCTGGCGGCCGTGCCGGGAGGAA
AACCAATTCTGTGTCCTCGGAGGACCACAGCCCAGTTGGGCCCCAGGCGAAACCCAGCCTGGAGCTTGCAGGCAGGACGACTGTTCAGCA
CGCAGACCGCCGAGGACAAGGAGGAACCCCTGCACTCGATTATCAGCAGCACAGAGAGCGTGCAGGGTTCCACTTCCAAACATGAGTTCC
AGGCCGAGACAAAGAAGCTTTTGGACATTGTTGCCCGGTCCCTGTACTCAGAAAAAGAGGTGTTTATACGGGAGCTGATCTCCAATGCCA
GCGATGCCTTGGAAAAACTGCGTCACAAACTGGTGTCTGACGGCCAAGCACTGCCAGAAATGGAGATTCACTTGCAGACCAATGCCGAGA
AAGGCACCATCACCATCCAGGATACTGGTATCGGGATGACACAGGAAGAGCTGGTGTCCAACCTGGGGACGATTGCCAGATCGGGGTCAA
AGGCCTTCCTGGATGCTCTGCAGAACCAGGCTGAGGCCAGCAGCAAGATCATCGGCCAGTTTGGAGTGGGTTTCTACTCAGCTTTCATGG
TGGCTGACAGAGTGGAGGTCTATTCCCGCTCGGCAGCCCCGGGGAGCCTGGGTTACCAGTGGCTTTCAGATGGTTCTGGAGTGTTTGAAA
TCGCCGAAGCTTCGGGAGTTAGAACCGGGACAAAAATCATCATCCACCTGAAATCCGACTGCAAGGAGTTTTCCAGCGAGGCCCGGGTGC
GAGATGTGGTAACGAAGTACAGCAACTTCGTCAGCTTCCCCTTGTACTTGAATGGAAGGCGGATGAACACCTTGCAGGCCATCTGGATGA
TGGACCCCAAGGATGTCCGTGAGTGGCAACATGAGGAGTTCTACCGCTACGTCGCGCAGGCTCACGACAAGCCCCGCTACACCCTGCACT
ATAAGACGGACGCACCGCTCAACATCCGCAGCATCTTCTACGTGCCCGACATGAAACCGTCCATGTTTGATGTGAGCCGGGAGCTGGGCT
CCAGCGTTGCACTGTACAGCCGCAAAGTCCTCATCCAGACCAAGGCCACGGACATCCTGCCCAAGTGGCTGCGCTTCATCCGAGGTGTGG
TGGACAGTGAGGACATTCCCCTGAACCTCAGCCGGGAGCTGCTGCAGGAGAGCGCACTCATCAGGATGGTGTTCTTCCTGGAGGACGTCA
TGGCCTGCACCAAGCGCCTGCTGGAGTGGATCGCCGGCTGGCTACCACGTCACTGCATCGGGGCCATCCTGGTGTCGCTTCCCGCACTGG
CCGTCTACTCCCATGTCACCTCCGAATATGAGACCAACATACACTTCCCAGTGTTCACAGGCTCGGCCGCGCTGATTGCCGTCGTGCACT
ACTGTAACTTCTGCCAGCTCAGCTCCTGGATGAGGTCCTCCCTCGCCACCGTCGTGGGGGCCGGGCCGCTGCTCCTGCTCTACGTCTCCC
TGTGCCCAGACAGTTCTGTATTAACTTCGCCCCTTGACGCAGTACAGAATTTCAGTTCCGAGAGGAACCCGTGCAATAGTTCGGTGCCGC
GTGACCTCCGGCGGCCCGCCAGCCTCATCGGCCAGGAGGTGGTTCTCGTCTTCTTTCTCCTGCTCTTGTTGGTCTGGTTCCTGAATCGCG
AATTTGAAGTCAGCTACCGCCTCCACTACCACGGAGACGTGGAAGCGGATCTTCACCGCACCAAGATCCAGAGCATGCGGGACCAGGCAG
ACTGGCTGCTGAGGAACATCATCCCCTACCACGTGGCTGAGCAGCTGAAGGTGTCCCAGACCTACTCCAAGAACCATGACAGCGGAGGGG
TGATCTTCGCCAGCATCGTCAACTTCAGCGAGTTCTACGAGGAGAACTACGAGGGCGGCAAGGAGTGCTACCGGGTCCTCAACGAGCTCA
TCGGGGACTTTGACGAGCTCCTAAGCAAGCCGGACTACAGCAGCATCGAGAAGATCAAGACCATCGGAGCCACGTACATGGCGGCGTCAG
GGCTGAACACCGCGCAGGCCCAGGACGGCAGCCACCCGCAGGAGCACCTGCAGATCCTGTTCGAGTTCGCCAAGGAGATGATGCGCGTGG
TGGACGACTTCAACAACAACATGCTGTGGTTCAACTTCAAGCTCCGCGTCGGCTTCAACCATGGGCCCCTCACGGCCGGGGTCATCGGCA
CCACCAAGCTGCTGTACGACATCTGGGGAGACACCGTCAACATCGCCAGCAGGATGGACACCACCGGCGTGGAGTGCCGCATCCAGGTGA
GCGAAGAGAGCTACCGCGTCTTGAGCAAGATGGGCTATGACTTCGACTACAGAGGGACCGTGAATGTCAAGGGGAAAGGCCAGATGAAGA
CCTACCTGTACCCAAAGTGCACGGATCACAGGGTCATCCCACAGCACCAGCTGTCCATCTCCCCAGACATCCGCGTCCAGGTGGATGGCA
GCATCGGACGGTCTCCCACAGACGAGATTGCCAACCTGGTGCCTTCTGTCCAGTATGTGGACAAGACATCTCTGGGTTCTGACAGCAGCA
CGCAGGCCAAGGATGCCCACCTGTCCCCCAAGAGACCGTGGAAGGAGCCCGTCAAAGCCGAAGAAAGGGGTCGATTTGGCAAAGCCATAG
AGAAAGACGACTGTGACGAAACAGGAATAGAAGAAGCCAACGAACTCACCAAGCTCAACGTTTCAAAGAGTGTGTGAGGCGGCGCCCACC
CGCTGCCCGAGGTGCTCTGTTTGTCGAAACACAGTAATATTTGTATTTGGCTGTTGTGCTTTCCAAGCGCCACAGTTGCCCTCCCCGGAC
GTGGTGTTATGTGGTCATTTCAGCCCTAACTTCTGTGTGGATCACAGTTATTCAGGGTTCATTTTCATCCATTCTTCCCTTTCGCTCCCT
TCCCTGGAAACCCCGCTGCCTCTGGGTCATCCGTTCAGCACGTGGTGGAGAACAAGTGCCTTCAGGGCTGGCCTCGGCCTCGAGTCTCGG
GACAGAGGCCGCCAGTGGAGATCATGGCTTTGGGTATTATTTGACTTTTAGAACAAAAGCTGTGGTTAAGATCTCATTTTTATTGCTTTT
TCCCACGTCCCACGAGACACTATTTTCGGTTCTCTGGCTAATACCCTGTTTTTGAGTTTATTTTGTTTCTGTCTATGTCACAGTGTTCCT
CTACGACCCGACCTCTCTATGTAAGCACACATGCGCACACACACTTGCATTCATGAATCTGATATAAAGTGCCAGTAATCCGCCAAGAGG
GGGTGCGAAGGGGGCATGTCACGACAGCTCCGCCACCCCCCATTGCCCACCCGCACTTTCCCGAGCACCGCGCCCCGTGGGCTGTGGGTG
AGCCGCGCTCCCTGCACTGAGCGGGTTTAGGGGCTCGCCCACATGCATGCAGGCCAAGACAGCAAATGCCAGCCGGGCACGACGCCCGTG
TGCCCAGGCCTCGGGGGTCTCAGAGCCGCCTCTCACCCCCGACCCTCCACCCAGGGGTCTCCCCATCGGGAGTGGAGGTGTTGGTCCTGG
AAGCTGACTCATCGGAGAGGGAAATACCAAATAAACATCCGAGGTTGCATTTATTTATTTATTTATTTACCCGGAAGCATGTGCGCTCCC
GGGAGGGGTGCTGGGTCCTCAGGGTGGGGGGTCATAGCCACAGGGGAGGGCAGTTCCCAGGAAGGTAACCAGATGTCTCTTTTGTGTTTT
GGCCACCTGGGGCCGCCCCCAACCTCCCCACCCCAAGAGGGGTCTGAGTGGGACCTCAAAGCATGGCCAGTGCAATTCTGAGGCTAGGGG
AATAGGAGAAGCCCACCAGCTGCCCCTGCCACCCACGGGGGCTCCTCCCTGCCGGGGTCCAGCTCAGAACCACGGGGGTCTGTGCCGGCA
GCACCGGTGCCATCTTGGCTTCCACAAATTCCAGAAGTTTCTTGGCTGCCTCCCGCTCTCAGATGGCACAGGGCCTATCAGTGGCAGGAT
TTAATCTGGGGAGCAAATTCCAGCTCTGAAATGGAGTTCTCACACCGTATCTAGGGACAGAGGCATCTGGATGCAAACGCGGGGTTTGTT
AGGGGCGGAATCCCGAGGGTGGTGTGGGGGAGCTCCGTCCGGGCAGTTGGCTGCTGGTCCTGTCTGATTATGTTTTGCCATATTGAGTCT
GAAGTTTGTGTGGAAGTGAGCTCGCCCGAGTTGTCCGGTCGGAGTTGTAGCCAGTCTTTCAGGGGACCCCGGGACGCTGATGAGGCCCAG
GGTGCACTCCTTGTCAGTCTTGCCCGTTGTCCCTGTGCATTTTGCTTTCCGCTGTCAAATCTCACTGTCTCGTTTTCACACCGCATCAGT
CCCCATCATCACTACTCCTCCCCAGAGACATACAGATTGCCCTCCCCGGCATGAAGAAGTCACAATTCTGACCCGCCACCTCTCCAGGGG
CGGTGCCTGGGATGGCCACCCATCAGGACAGCCAGAGCCAGGGTCCCGGCGTCCTGAGAGTCCAGGGCACCTCCCCCCATTAGCTGTAAG
GTTTCCTGTCAGGTGTGACTGTCAGTTTGCTGGTCTTCCAATACCGAAGAAAGGGTGGTTGTGACAATACCTCTTGCTTCTAAAGAATGT
ATTATAAAACACCGCAGATTTTTTTTTTTCCTTAAAAAACACTACCTGATGCTTTCCTTGTTCGTGGGGATTGTGGTCACATGAAGCTCT
TTCTGCATCAGTATTAAGGTGTATATTTGAATGTCCTCCCCTCCCCTTTCCCCTCCAGGCTGTGTAGCTTTGAGGGGCTGGGCGTTTGCT
CACGACCTTGCTGTCTCGCTCAGAACATGCTCCGCAAAGTTCTCCGCACACACTTCTTCCCCATCAAGCCCATTTCCTTCCCCAACCACA
AAGGTGTTTGTGATTCCTCACCCCGGGAAACCAAGGAGCTGCAAAGTGGAGTCTGGTTCAGCCCCGTGCAGACTCACCCAGAGCTTAACG
TTGTCTTTCAAACACCCTGAGCCTTCCTAAACAGCCAGTGCAGACGTTCTCTCTGGGCCACGAAGCCCCTCGGGTCCTCCCCGTCCCCTG
CTCCGATGCATACCTCAGTGCAGAACCACAGAATCTCTGCAGCGGAAACGCCGTGCATCTCTTGTCTGTTGGCAGCGAGCACATCGTGCT
GGAGACACGAGTTTCTAAGCAGCTGGCACGAGGGCTGCTGACGGCATGGGTCGTGCTTCAGGGTGGCAATACCTCTTAGGAACTTAGGGC
AGGAAGCAATACTTCAGCATTGAATGTGTGTAAATAGTTGCTTTGAGTTGCAATTGCTATTTTCTTCTCAGTCCCAGCTCAGATCGAATT
ATATATCCATATATATATATATATATATATATATATATATATATATATATATATGGTAAACAAGCACACACAATTTTATCCAATGCAAAC
AAATGTAGAGCATCAGTTACAAAACCCTCGAATAGCTTGAGAGCCCCACAGGCTCTGCCACACCCGTGACTTCATCCACACTGACGTCAC
CCGCGGGGGCTCCCCCTGCACATTTGCACACGATCCGGAGAGCCGAAGGCCGCGTGCTTCCTGTCACATGGGCTGTAATCATTTGTAGTT
TCCAAAGACACGTCTGCATTTGAATTTCTAGATTTTCGAGGTAAGGAGTTTTTTTTAATTGGTTGTTTGGAAAATCACATCATGCCTAGA
ATCTGAAATTGAATTAGCAAGAACCGACTGTTTGCATTTTCCATATATCCTTTTATCTGCTCTTTTTAAATTGTTAATTCTAATAATTTC

>93755_93755_1_TRAP1-ADCY9_TRAP1_chr16_3721723_ENST00000246957_ADCY9_chr16_4029276_ENST00000294016_length(amino acids)=934AA_BP=420
MRAALWEYDMARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFSTQTAEDKEEPLHSIISSTESV
QGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSN
LGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDC
KEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPS
MFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRMVFFLEDVMACTKRLLEWIAGWLPRHCIG
AILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSE
RNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQT
YSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILF
EFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTV
NVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAE

--------------------------------------------------------------
>93755_93755_2_TRAP1-ADCY9_TRAP1_chr16_3721723_ENST00000538171_ADCY9_chr16_4029276_ENST00000294016_length(transcript)=5748nt_BP=1081nt
ACGACATGGCGCGCGAGCTGCGGGCGCTGCTGCTGTGGGGCCGCCGCCTGCGGCCTTTGCTGCGGGCGCCGGCGCTGGCGGCCGTGCCGG
GAGGTTCCACTTCCAAACATGAGTTCCAGGCCGAGACAAAGAAGCTTTTGGACATTGTTGCCCGGTCCCTGTACTCAGAAAAAGAGGTGT
TTATACGGGAGCTGATCTCCAATGCCAGCGATGCCTTGGAAAAACTGCGTCACAAACTGGTGTCTGACGGCCAAGCACTGCCAGAAATGG
AGATTCACTTGCAGACCAATGCCGAGAAAGGCACCATCACCATCCAGGATACTGGTATCGGGATGACACAGGAAGAGCTGGTGTCCAACC
TGGGGACGATTGCCAGATCGGGGTCAAAGGCCTTCCTGGATGCTCTGCAGAACCAGGCTGAGGCCAGCAGCAAGATCATCGGCCAGTTTG
GAGTGGGTTTCTACTCAGCTTTCATGGTGGCTGACAGAGTGGAGGTCTATTCCCGCTCGGCAGCCCCGGGGAGCCTGGGTTACCAGTGGC
TTTCAGATGGTTCTGGAGTGTTTGAAATCGCCGAAGCTTCGGGAGTTAGAACCGGGACAAAAATCATCATCCACCTGAAATCCGACTGCA
AGGAGTTTTCCAGCGAGGCCCGGGTGCGAGATGTGGTAACGAAGTACAGCAACTTCGTCAGCTTCCCCTTGTACTTGAATGGAAGGCGGA
TGAACACCTTGCAGGCCATCTGGATGATGGACCCCAAGGATGTCCGTGAGTGGCAACATGAGGAGTTCTACCGCTACGTCGCGCAGGCTC
ACGACAAGCCCCGCTACACCCTGCACTATAAGACGGACGCACCGCTCAACATCCGCAGCATCTTCTACGTGCCCGACATGAAACCGTCCA
TGTTTGATGTGAGCCGGGAGCTGGGCTCCAGCGTTGCACTGTACAGCCGCAAAGTCCTCATCCAGACCAAGGCCACGGACATCCTGCCCA
AGTGGCTGCGCTTCATCCGAGGTGTGGTGGACAGTGAGGACATTCCCCTGAACCTCAGCCGGGAGCTGCTGCAGGAGAGCGCACTCATCA
GGATGGTGTTCTTCCTGGAGGACGTCATGGCCTGCACCAAGCGCCTGCTGGAGTGGATCGCCGGCTGGCTACCACGTCACTGCATCGGGG
CCATCCTGGTGTCGCTTCCCGCACTGGCCGTCTACTCCCATGTCACCTCCGAATATGAGACCAACATACACTTCCCAGTGTTCACAGGCT
CGGCCGCGCTGATTGCCGTCGTGCACTACTGTAACTTCTGCCAGCTCAGCTCCTGGATGAGGTCCTCCCTCGCCACCGTCGTGGGGGCCG
GGCCGCTGCTCCTGCTCTACGTCTCCCTGTGCCCAGACAGTTCTGTATTAACTTCGCCCCTTGACGCAGTACAGAATTTCAGTTCCGAGA
GGAACCCGTGCAATAGTTCGGTGCCGCGTGACCTCCGGCGGCCCGCCAGCCTCATCGGCCAGGAGGTGGTTCTCGTCTTCTTTCTCCTGC
TCTTGTTGGTCTGGTTCCTGAATCGCGAATTTGAAGTCAGCTACCGCCTCCACTACCACGGAGACGTGGAAGCGGATCTTCACCGCACCA
AGATCCAGAGCATGCGGGACCAGGCAGACTGGCTGCTGAGGAACATCATCCCCTACCACGTGGCTGAGCAGCTGAAGGTGTCCCAGACCT
ACTCCAAGAACCATGACAGCGGAGGGGTGATCTTCGCCAGCATCGTCAACTTCAGCGAGTTCTACGAGGAGAACTACGAGGGCGGCAAGG
AGTGCTACCGGGTCCTCAACGAGCTCATCGGGGACTTTGACGAGCTCCTAAGCAAGCCGGACTACAGCAGCATCGAGAAGATCAAGACCA
TCGGAGCCACGTACATGGCGGCGTCAGGGCTGAACACCGCGCAGGCCCAGGACGGCAGCCACCCGCAGGAGCACCTGCAGATCCTGTTCG
AGTTCGCCAAGGAGATGATGCGCGTGGTGGACGACTTCAACAACAACATGCTGTGGTTCAACTTCAAGCTCCGCGTCGGCTTCAACCATG
GGCCCCTCACGGCCGGGGTCATCGGCACCACCAAGCTGCTGTACGACATCTGGGGAGACACCGTCAACATCGCCAGCAGGATGGACACCA
CCGGCGTGGAGTGCCGCATCCAGGTGAGCGAAGAGAGCTACCGCGTCTTGAGCAAGATGGGCTATGACTTCGACTACAGAGGGACCGTGA
ATGTCAAGGGGAAAGGCCAGATGAAGACCTACCTGTACCCAAAGTGCACGGATCACAGGGTCATCCCACAGCACCAGCTGTCCATCTCCC
CAGACATCCGCGTCCAGGTGGATGGCAGCATCGGACGGTCTCCCACAGACGAGATTGCCAACCTGGTGCCTTCTGTCCAGTATGTGGACA
AGACATCTCTGGGTTCTGACAGCAGCACGCAGGCCAAGGATGCCCACCTGTCCCCCAAGAGACCGTGGAAGGAGCCCGTCAAAGCCGAAG
AAAGGGGTCGATTTGGCAAAGCCATAGAGAAAGACGACTGTGACGAAACAGGAATAGAAGAAGCCAACGAACTCACCAAGCTCAACGTTT
CAAAGAGTGTGTGAGGCGGCGCCCACCCGCTGCCCGAGGTGCTCTGTTTGTCGAAACACAGTAATATTTGTATTTGGCTGTTGTGCTTTC
CAAGCGCCACAGTTGCCCTCCCCGGACGTGGTGTTATGTGGTCATTTCAGCCCTAACTTCTGTGTGGATCACAGTTATTCAGGGTTCATT
TTCATCCATTCTTCCCTTTCGCTCCCTTCCCTGGAAACCCCGCTGCCTCTGGGTCATCCGTTCAGCACGTGGTGGAGAACAAGTGCCTTC
AGGGCTGGCCTCGGCCTCGAGTCTCGGGACAGAGGCCGCCAGTGGAGATCATGGCTTTGGGTATTATTTGACTTTTAGAACAAAAGCTGT
GGTTAAGATCTCATTTTTATTGCTTTTTCCCACGTCCCACGAGACACTATTTTCGGTTCTCTGGCTAATACCCTGTTTTTGAGTTTATTT
TGTTTCTGTCTATGTCACAGTGTTCCTCTACGACCCGACCTCTCTATGTAAGCACACATGCGCACACACACTTGCATTCATGAATCTGAT
ATAAAGTGCCAGTAATCCGCCAAGAGGGGGTGCGAAGGGGGCATGTCACGACAGCTCCGCCACCCCCCATTGCCCACCCGCACTTTCCCG
AGCACCGCGCCCCGTGGGCTGTGGGTGAGCCGCGCTCCCTGCACTGAGCGGGTTTAGGGGCTCGCCCACATGCATGCAGGCCAAGACAGC
AAATGCCAGCCGGGCACGACGCCCGTGTGCCCAGGCCTCGGGGGTCTCAGAGCCGCCTCTCACCCCCGACCCTCCACCCAGGGGTCTCCC
CATCGGGAGTGGAGGTGTTGGTCCTGGAAGCTGACTCATCGGAGAGGGAAATACCAAATAAACATCCGAGGTTGCATTTATTTATTTATT
TATTTACCCGGAAGCATGTGCGCTCCCGGGAGGGGTGCTGGGTCCTCAGGGTGGGGGGTCATAGCCACAGGGGAGGGCAGTTCCCAGGAA
GGTAACCAGATGTCTCTTTTGTGTTTTGGCCACCTGGGGCCGCCCCCAACCTCCCCACCCCAAGAGGGGTCTGAGTGGGACCTCAAAGCA
TGGCCAGTGCAATTCTGAGGCTAGGGGAATAGGAGAAGCCCACCAGCTGCCCCTGCCACCCACGGGGGCTCCTCCCTGCCGGGGTCCAGC
TCAGAACCACGGGGGTCTGTGCCGGCAGCACCGGTGCCATCTTGGCTTCCACAAATTCCAGAAGTTTCTTGGCTGCCTCCCGCTCTCAGA
TGGCACAGGGCCTATCAGTGGCAGGATTTAATCTGGGGAGCAAATTCCAGCTCTGAAATGGAGTTCTCACACCGTATCTAGGGACAGAGG
CATCTGGATGCAAACGCGGGGTTTGTTAGGGGCGGAATCCCGAGGGTGGTGTGGGGGAGCTCCGTCCGGGCAGTTGGCTGCTGGTCCTGT
CTGATTATGTTTTGCCATATTGAGTCTGAAGTTTGTGTGGAAGTGAGCTCGCCCGAGTTGTCCGGTCGGAGTTGTAGCCAGTCTTTCAGG
GGACCCCGGGACGCTGATGAGGCCCAGGGTGCACTCCTTGTCAGTCTTGCCCGTTGTCCCTGTGCATTTTGCTTTCCGCTGTCAAATCTC
ACTGTCTCGTTTTCACACCGCATCAGTCCCCATCATCACTACTCCTCCCCAGAGACATACAGATTGCCCTCCCCGGCATGAAGAAGTCAC
AATTCTGACCCGCCACCTCTCCAGGGGCGGTGCCTGGGATGGCCACCCATCAGGACAGCCAGAGCCAGGGTCCCGGCGTCCTGAGAGTCC
AGGGCACCTCCCCCCATTAGCTGTAAGGTTTCCTGTCAGGTGTGACTGTCAGTTTGCTGGTCTTCCAATACCGAAGAAAGGGTGGTTGTG
ACAATACCTCTTGCTTCTAAAGAATGTATTATAAAACACCGCAGATTTTTTTTTTTCCTTAAAAAACACTACCTGATGCTTTCCTTGTTC
GTGGGGATTGTGGTCACATGAAGCTCTTTCTGCATCAGTATTAAGGTGTATATTTGAATGTCCTCCCCTCCCCTTTCCCCTCCAGGCTGT
GTAGCTTTGAGGGGCTGGGCGTTTGCTCACGACCTTGCTGTCTCGCTCAGAACATGCTCCGCAAAGTTCTCCGCACACACTTCTTCCCCA
TCAAGCCCATTTCCTTCCCCAACCACAAAGGTGTTTGTGATTCCTCACCCCGGGAAACCAAGGAGCTGCAAAGTGGAGTCTGGTTCAGCC
CCGTGCAGACTCACCCAGAGCTTAACGTTGTCTTTCAAACACCCTGAGCCTTCCTAAACAGCCAGTGCAGACGTTCTCTCTGGGCCACGA
AGCCCCTCGGGTCCTCCCCGTCCCCTGCTCCGATGCATACCTCAGTGCAGAACCACAGAATCTCTGCAGCGGAAACGCCGTGCATCTCTT
GTCTGTTGGCAGCGAGCACATCGTGCTGGAGACACGAGTTTCTAAGCAGCTGGCACGAGGGCTGCTGACGGCATGGGTCGTGCTTCAGGG
TGGCAATACCTCTTAGGAACTTAGGGCAGGAAGCAATACTTCAGCATTGAATGTGTGTAAATAGTTGCTTTGAGTTGCAATTGCTATTTT
CTTCTCAGTCCCAGCTCAGATCGAATTATATATCCATATATATATATATATATATATATATATATATATATATATATATATGGTAAACAA
GCACACACAATTTTATCCAATGCAAACAAATGTAGAGCATCAGTTACAAAACCCTCGAATAGCTTGAGAGCCCCACAGGCTCTGCCACAC
CCGTGACTTCATCCACACTGACGTCACCCGCGGGGGCTCCCCCTGCACATTTGCACACGATCCGGAGAGCCGAAGGCCGCGTGCTTCCTG
TCACATGGGCTGTAATCATTTGTAGTTTCCAAAGACACGTCTGCATTTGAATTTCTAGATTTTCGAGGTAAGGAGTTTTTTTTAATTGGT
TGTTTGGAAAATCACATCATGCCTAGAATCTGAAATTGAATTAGCAAGAACCGACTGTTTGCATTTTCCATATATCCTTTTATCTGCTCT

>93755_93755_2_TRAP1-ADCY9_TRAP1_chr16_3721723_ENST00000538171_ADCY9_chr16_4029276_ENST00000294016_length(amino acids)=872AA_BP=358
MARELRALLLWGRRLRPLLRAPALAAVPGGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVSDGQALPEMEI
HLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLS
DGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHD
KPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRM
VFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGP
LLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKI
QSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIG
ATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTG
VECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKT

--------------------------------------------------------------
>93755_93755_3_TRAP1-ADCY9_TRAP1_chr16_3721723_ENST00000575671_ADCY9_chr16_4029276_ENST00000294016_length(transcript)=6005nt_BP=1338nt
GTGCTCCTCAGCTGCACAGGCCACATTGCAGGTGCTCGGCAGGCTGTCGCATTGCACCTGGCAGAACGTTCCTGTTGTTGGAGAAAGTTC
CATCGGACAACGTGGGCCAGGGCAGTGGGCGTGTGTATTTTACTTGACTTTGGCCTTAGGACCTTTGGCAGTATTATAGTAGAAAAATGA
AGTGCTGTGCGGTGCTTACAGACGCATGCGCGTGATTTCTACTCTTTTTCCCACAAAGTGTAGAGTCCAGGAGACTTGAATATGGAAGCC
AGTTTGGAGCCTCTCCTCACTCCTGGCCTTCCTATGGAAGGAGCTTATTCAAGGGAAAGAGCTTATTCAAGCTGCTCTTTCCCCACCCCC
AGGTGTGACCCACAGGCCTCCACCTGTCTGGGACAGGCAGGACTGTGAGCTTTGGGAATCAAATGGAAAACACACTTGTCCCACTGCTGC
CAGCTGGTTGTCCTAGGGCTAATGTGTCACCTCTCTGTGACTTAGCTCTTCACGTGTAGAATGGGGTGGAAAAGTACTCGGTGTGGCTGT
TTTCAGGATGAAGGGGTCTTAGCGGTGCTCGCAGAAGAGCCACGGTGTTGGGAGTGTCTGCTCTCTGGAGGGGAGGCTGCCTCACTAACT
GGCCTCTGCCCCACAGGCCTTCCTGGATGCTCTGCAGAACCAGGCTGAGGCCAGCAGCAAGATCATCGGCCAGTTTGGAGTGGGTTTCTA
CTCAGCTTTCATGGTGGCTGACAGAGTGGAGGTCTATTCCCGCTCGGCAGCCCCGGGGAGCCTGGGTTACCAGTGGCTTTCAGATGGTTC
TGGAGTGTTTGAAATCGCCGAAGCTTCGGGAGTTAGAACCGGGACAAAAATCATCATCCACCTGAAATCCGACTGCAAGGAGTTTTCCAG
CGAGGCCCGGGTGCGAGATGTGGTAACGAAGTACAGCAACTTCGTCAGCTTCCCCTTGTACTTGAATGGAAGGCGGATGAACACCTTGCA
GGCCATCTGGATGATGGACCCCAAGGATGTCCGTGAGTGGCAACATGAGGAGTTCTACCGCTACGTCGCGCAGGCTCACGACAAGCCCCG
CTACACCCTGCACTATAAGACGGACGCACCGCTCAACATCCGCAGCATCTTCTACGTGCCCGACATGAAACCGTCCATGTTTGATGTGAG
CCGGGAGCTGGGCTCCAGCGTTGCACTGTACAGCCGCAAAGTCCTCATCCAGACCAAGGCCACGGACATCCTGCCCAAGTGGCTGCGCTT
CATCCGAGGTGTGGTGGACAGTGAGGACATTCCCCTGAACCTCAGCCGGGAGCTGCTGCAGGAGAGCGCACTCATCAGGATGGTGTTCTT
CCTGGAGGACGTCATGGCCTGCACCAAGCGCCTGCTGGAGTGGATCGCCGGCTGGCTACCACGTCACTGCATCGGGGCCATCCTGGTGTC
GCTTCCCGCACTGGCCGTCTACTCCCATGTCACCTCCGAATATGAGACCAACATACACTTCCCAGTGTTCACAGGCTCGGCCGCGCTGAT
TGCCGTCGTGCACTACTGTAACTTCTGCCAGCTCAGCTCCTGGATGAGGTCCTCCCTCGCCACCGTCGTGGGGGCCGGGCCGCTGCTCCT
GCTCTACGTCTCCCTGTGCCCAGACAGTTCTGTATTAACTTCGCCCCTTGACGCAGTACAGAATTTCAGTTCCGAGAGGAACCCGTGCAA
TAGTTCGGTGCCGCGTGACCTCCGGCGGCCCGCCAGCCTCATCGGCCAGGAGGTGGTTCTCGTCTTCTTTCTCCTGCTCTTGTTGGTCTG
GTTCCTGAATCGCGAATTTGAAGTCAGCTACCGCCTCCACTACCACGGAGACGTGGAAGCGGATCTTCACCGCACCAAGATCCAGAGCAT
GCGGGACCAGGCAGACTGGCTGCTGAGGAACATCATCCCCTACCACGTGGCTGAGCAGCTGAAGGTGTCCCAGACCTACTCCAAGAACCA
TGACAGCGGAGGGGTGATCTTCGCCAGCATCGTCAACTTCAGCGAGTTCTACGAGGAGAACTACGAGGGCGGCAAGGAGTGCTACCGGGT
CCTCAACGAGCTCATCGGGGACTTTGACGAGCTCCTAAGCAAGCCGGACTACAGCAGCATCGAGAAGATCAAGACCATCGGAGCCACGTA
CATGGCGGCGTCAGGGCTGAACACCGCGCAGGCCCAGGACGGCAGCCACCCGCAGGAGCACCTGCAGATCCTGTTCGAGTTCGCCAAGGA
GATGATGCGCGTGGTGGACGACTTCAACAACAACATGCTGTGGTTCAACTTCAAGCTCCGCGTCGGCTTCAACCATGGGCCCCTCACGGC
CGGGGTCATCGGCACCACCAAGCTGCTGTACGACATCTGGGGAGACACCGTCAACATCGCCAGCAGGATGGACACCACCGGCGTGGAGTG
CCGCATCCAGGTGAGCGAAGAGAGCTACCGCGTCTTGAGCAAGATGGGCTATGACTTCGACTACAGAGGGACCGTGAATGTCAAGGGGAA
AGGCCAGATGAAGACCTACCTGTACCCAAAGTGCACGGATCACAGGGTCATCCCACAGCACCAGCTGTCCATCTCCCCAGACATCCGCGT
CCAGGTGGATGGCAGCATCGGACGGTCTCCCACAGACGAGATTGCCAACCTGGTGCCTTCTGTCCAGTATGTGGACAAGACATCTCTGGG
TTCTGACAGCAGCACGCAGGCCAAGGATGCCCACCTGTCCCCCAAGAGACCGTGGAAGGAGCCCGTCAAAGCCGAAGAAAGGGGTCGATT
TGGCAAAGCCATAGAGAAAGACGACTGTGACGAAACAGGAATAGAAGAAGCCAACGAACTCACCAAGCTCAACGTTTCAAAGAGTGTGTG
AGGCGGCGCCCACCCGCTGCCCGAGGTGCTCTGTTTGTCGAAACACAGTAATATTTGTATTTGGCTGTTGTGCTTTCCAAGCGCCACAGT
TGCCCTCCCCGGACGTGGTGTTATGTGGTCATTTCAGCCCTAACTTCTGTGTGGATCACAGTTATTCAGGGTTCATTTTCATCCATTCTT
CCCTTTCGCTCCCTTCCCTGGAAACCCCGCTGCCTCTGGGTCATCCGTTCAGCACGTGGTGGAGAACAAGTGCCTTCAGGGCTGGCCTCG
GCCTCGAGTCTCGGGACAGAGGCCGCCAGTGGAGATCATGGCTTTGGGTATTATTTGACTTTTAGAACAAAAGCTGTGGTTAAGATCTCA
TTTTTATTGCTTTTTCCCACGTCCCACGAGACACTATTTTCGGTTCTCTGGCTAATACCCTGTTTTTGAGTTTATTTTGTTTCTGTCTAT
GTCACAGTGTTCCTCTACGACCCGACCTCTCTATGTAAGCACACATGCGCACACACACTTGCATTCATGAATCTGATATAAAGTGCCAGT
AATCCGCCAAGAGGGGGTGCGAAGGGGGCATGTCACGACAGCTCCGCCACCCCCCATTGCCCACCCGCACTTTCCCGAGCACCGCGCCCC
GTGGGCTGTGGGTGAGCCGCGCTCCCTGCACTGAGCGGGTTTAGGGGCTCGCCCACATGCATGCAGGCCAAGACAGCAAATGCCAGCCGG
GCACGACGCCCGTGTGCCCAGGCCTCGGGGGTCTCAGAGCCGCCTCTCACCCCCGACCCTCCACCCAGGGGTCTCCCCATCGGGAGTGGA
GGTGTTGGTCCTGGAAGCTGACTCATCGGAGAGGGAAATACCAAATAAACATCCGAGGTTGCATTTATTTATTTATTTATTTACCCGGAA
GCATGTGCGCTCCCGGGAGGGGTGCTGGGTCCTCAGGGTGGGGGGTCATAGCCACAGGGGAGGGCAGTTCCCAGGAAGGTAACCAGATGT
CTCTTTTGTGTTTTGGCCACCTGGGGCCGCCCCCAACCTCCCCACCCCAAGAGGGGTCTGAGTGGGACCTCAAAGCATGGCCAGTGCAAT
TCTGAGGCTAGGGGAATAGGAGAAGCCCACCAGCTGCCCCTGCCACCCACGGGGGCTCCTCCCTGCCGGGGTCCAGCTCAGAACCACGGG
GGTCTGTGCCGGCAGCACCGGTGCCATCTTGGCTTCCACAAATTCCAGAAGTTTCTTGGCTGCCTCCCGCTCTCAGATGGCACAGGGCCT
ATCAGTGGCAGGATTTAATCTGGGGAGCAAATTCCAGCTCTGAAATGGAGTTCTCACACCGTATCTAGGGACAGAGGCATCTGGATGCAA
ACGCGGGGTTTGTTAGGGGCGGAATCCCGAGGGTGGTGTGGGGGAGCTCCGTCCGGGCAGTTGGCTGCTGGTCCTGTCTGATTATGTTTT
GCCATATTGAGTCTGAAGTTTGTGTGGAAGTGAGCTCGCCCGAGTTGTCCGGTCGGAGTTGTAGCCAGTCTTTCAGGGGACCCCGGGACG
CTGATGAGGCCCAGGGTGCACTCCTTGTCAGTCTTGCCCGTTGTCCCTGTGCATTTTGCTTTCCGCTGTCAAATCTCACTGTCTCGTTTT
CACACCGCATCAGTCCCCATCATCACTACTCCTCCCCAGAGACATACAGATTGCCCTCCCCGGCATGAAGAAGTCACAATTCTGACCCGC
CACCTCTCCAGGGGCGGTGCCTGGGATGGCCACCCATCAGGACAGCCAGAGCCAGGGTCCCGGCGTCCTGAGAGTCCAGGGCACCTCCCC
CCATTAGCTGTAAGGTTTCCTGTCAGGTGTGACTGTCAGTTTGCTGGTCTTCCAATACCGAAGAAAGGGTGGTTGTGACAATACCTCTTG
CTTCTAAAGAATGTATTATAAAACACCGCAGATTTTTTTTTTTCCTTAAAAAACACTACCTGATGCTTTCCTTGTTCGTGGGGATTGTGG
TCACATGAAGCTCTTTCTGCATCAGTATTAAGGTGTATATTTGAATGTCCTCCCCTCCCCTTTCCCCTCCAGGCTGTGTAGCTTTGAGGG
GCTGGGCGTTTGCTCACGACCTTGCTGTCTCGCTCAGAACATGCTCCGCAAAGTTCTCCGCACACACTTCTTCCCCATCAAGCCCATTTC
CTTCCCCAACCACAAAGGTGTTTGTGATTCCTCACCCCGGGAAACCAAGGAGCTGCAAAGTGGAGTCTGGTTCAGCCCCGTGCAGACTCA
CCCAGAGCTTAACGTTGTCTTTCAAACACCCTGAGCCTTCCTAAACAGCCAGTGCAGACGTTCTCTCTGGGCCACGAAGCCCCTCGGGTC
CTCCCCGTCCCCTGCTCCGATGCATACCTCAGTGCAGAACCACAGAATCTCTGCAGCGGAAACGCCGTGCATCTCTTGTCTGTTGGCAGC
GAGCACATCGTGCTGGAGACACGAGTTTCTAAGCAGCTGGCACGAGGGCTGCTGACGGCATGGGTCGTGCTTCAGGGTGGCAATACCTCT
TAGGAACTTAGGGCAGGAAGCAATACTTCAGCATTGAATGTGTGTAAATAGTTGCTTTGAGTTGCAATTGCTATTTTCTTCTCAGTCCCA
GCTCAGATCGAATTATATATCCATATATATATATATATATATATATATATATATATATATATATATATGGTAAACAAGCACACACAATTT
TATCCAATGCAAACAAATGTAGAGCATCAGTTACAAAACCCTCGAATAGCTTGAGAGCCCCACAGGCTCTGCCACACCCGTGACTTCATC
CACACTGACGTCACCCGCGGGGGCTCCCCCTGCACATTTGCACACGATCCGGAGAGCCGAAGGCCGCGTGCTTCCTGTCACATGGGCTGT
AATCATTTGTAGTTTCCAAAGACACGTCTGCATTTGAATTTCTAGATTTTCGAGGTAAGGAGTTTTTTTTAATTGGTTGTTTGGAAAATC
ACATCATGCCTAGAATCTGAAATTGAATTAGCAAGAACCGACTGTTTGCATTTTCCATATATCCTTTTATCTGCTCTTTTTAAATTGTTA

>93755_93755_3_TRAP1-ADCY9_TRAP1_chr16_3721723_ENST00000575671_ADCY9_chr16_4029276_ENST00000294016_length(amino acids)=750AA_BP=236
MASAPQAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFS
SEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDV
SRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILV
SLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPC
NSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKN
HDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAK
EMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKG
KGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRAP1-ADCY9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRAP1-ADCY9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRAP1-ADCY9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource