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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TRAPPC9-KCNK9 (FusionGDB2 ID:93847)

Fusion Gene Summary for TRAPPC9-KCNK9

Fusion gene summary

Fusion gene information	Fusion gene name: TRAPPC9-KCNK9
	Fusion gene ID: 93847
		Hgene	Tgene
	Gene symbol	TRAPPC9	KCNK9
	Gene ID	83696	51305
	Gene name	trafficking protein particle complex 9	potassium two pore domain channel subfamily K member 9
	Synonyms	IBP\|IKBKBBP\|MRT13\|NIBP\|T1\|TRS120	K2p9.1\|KT3.2\|TASK-3\|TASK3
	Cytomap	8q24.3	8q24.3
	Type of gene	protein-coding	protein-coding
	Description	trafficking protein particle complex subunit 9IKK2 binding proteinNIK and IKK-beta binding proteinNIK- and IKBKB-binding proteinTRAPP 120 kDa subunittularik gene 1 protein	potassium channel subfamily K member 9TWIK-related acid-sensitive K(+) channel 3TWIK-related acid-sensitive K+ 3acid-sensitive potassium channel protein TASK-3potassium channel, two pore domain subfamily K, member 9two pore K(+) channel KT3.2two por
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000389327, ENST00000389328, ENST00000438773, ENST00000522504,	ENST00000523477, ENST00000303015, ENST00000520439,
Fusion gene scores	* DoF score	26 X 21 X 11=6006	1 X 1 X 2=2
	# samples	31	2
	** MAII score	log2(31/6006*10)=-4.27606435428291 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/2*10)=3.32192809488736
Context	PubMed: TRAPPC9 [Title/Abstract] AND KCNK9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TRAPPC9(140898123)-KCNK9(140631342), # samples:2
Anticipated loss of major functional domain due to fusion event.	TRAPPC9-KCNK9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TRAPPC9-KCNK9 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KCNK9	GO:1990573	potassium ion import across plasma membrane	11042359

Fusion gene breakpoints across TRAPPC9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KCNK9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-B6-A0IG-01A	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
ChimerDB4	LUAD	TCGA-MP-A4TE	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
ChimerDB4	STAD	TCGA-HU-8238-01A	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-

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Fusion Gene ORF analysis for TRAPPC9-KCNK9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000389327	ENST00000523477	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
5CDS-intron	ENST00000389327	ENST00000523477	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
5CDS-intron	ENST00000389328	ENST00000523477	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
5CDS-intron	ENST00000389328	ENST00000523477	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
5CDS-intron	ENST00000438773	ENST00000523477	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
5CDS-intron	ENST00000438773	ENST00000523477	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
Frame-shift	ENST00000389327	ENST00000303015	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
Frame-shift	ENST00000389327	ENST00000520439	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
Frame-shift	ENST00000389327	ENST00000520439	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
Frame-shift	ENST00000389328	ENST00000303015	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
Frame-shift	ENST00000389328	ENST00000520439	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
Frame-shift	ENST00000389328	ENST00000520439	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
Frame-shift	ENST00000438773	ENST00000303015	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
Frame-shift	ENST00000438773	ENST00000520439	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
Frame-shift	ENST00000438773	ENST00000520439	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
In-frame	ENST00000389327	ENST00000303015	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
In-frame	ENST00000389328	ENST00000303015	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
In-frame	ENST00000438773	ENST00000303015	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
intron-3CDS	ENST00000522504	ENST00000303015	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
intron-3CDS	ENST00000522504	ENST00000303015	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
intron-3CDS	ENST00000522504	ENST00000520439	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
intron-3CDS	ENST00000522504	ENST00000520439	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-
intron-intron	ENST00000522504	ENST00000523477	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-
intron-intron	ENST00000522504	ENST00000523477	TRAPPC9	chr8	141231558	-	KCNK9	chr8	140631342	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000389327	TRAPPC9	chr8	140898123	-	ENST00000303015	KCNK9	chr8	140631342	-	4118	3162	41	4003	1320
ENST00000389328	TRAPPC9	chr8	140898123	-	ENST00000303015	KCNK9	chr8	140631342	-	4320	3364	15	4205	1396
ENST00000438773	TRAPPC9	chr8	140898123	-	ENST00000303015	KCNK9	chr8	140631342	-	4145	3189	41	4030	1329

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000389327	ENST00000303015	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-	0.002629037	0.99737096
ENST00000389328	ENST00000303015	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-	0.001852312	0.9981477
ENST00000438773	ENST00000303015	TRAPPC9	chr8	140898123	-	KCNK9	chr8	140631342	-	0.002579375	0.99742067

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Fusion Genomic Features for TRAPPC9-KCNK9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRAPPC9-KCNK9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:140898123/chr8:140631342)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

195_207

297.3333333333333

Intramembrane

Pore-forming%3B Name%3DPore-forming 2

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

195_207

375.0

Intramembrane

Pore-forming%3B Name%3DPore-forming 2

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

102_107

297.3333333333333

Topological domain

Extracellular

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

129_158

297.3333333333333

Topological domain

Cytoplasmic

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

180_194

297.3333333333333

Topological domain

Extracellular

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

208_218

297.3333333333333

Topological domain

Extracellular

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

240_374

297.3333333333333

Topological domain

Cytoplasmic

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

102_107

375.0

Topological domain

Extracellular

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

129_158

375.0

Topological domain

Cytoplasmic

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

180_194

375.0

Topological domain

Extracellular

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

208_218

375.0

Topological domain

Extracellular

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

240_374

375.0

Topological domain

Cytoplasmic

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

108_128

297.3333333333333

Transmembrane

Helical

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

159_179

297.3333333333333

Transmembrane

Helical

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

219_239

297.3333333333333

Transmembrane

Helical

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

108_128

375.0

Transmembrane

Helical

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

159_179

375.0

Transmembrane

Helical

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

219_239

375.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

89_101

297.3333333333333

Intramembrane

Pore-forming%3B Name%3DPore-forming 1

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

89_101

375.0

Intramembrane

Pore-forming%3B Name%3DPore-forming 1

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

1_8

297.3333333333333

Topological domain

Cytoplasmic

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

30_88

297.3333333333333

Topological domain

Extracellular

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

1_8

375.0

Topological domain

Cytoplasmic

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

30_88

375.0

Topological domain

Extracellular

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000303015

9_29

297.3333333333333

Transmembrane

Helical

Tgene

KCNK9

chr8:140898123

chr8:140631342

ENST00000520439

9_29

375.0

Transmembrane

Helical

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Fusion Gene Sequence for TRAPPC9-KCNK9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>93847_93847_1_TRAPPC9-KCNK9_TRAPPC9_chr8_140898123_ENST00000389327_KCNK9_chr8_140631342_ENST00000303015_length(transcript)=4118nt_BP=3162nt
AGCGCCGGCTCGGCCGCCAGTAGGAAGCGCCAGCCCAGAGCCTGGGAAGTGGCCGCAGAGGCTGCTCGGCCCCGCTGCCCGCCAGGTCGT
GGGCTCCCGCTCCGGGCCCGGGGCCACCGGCTGTGGACTTCAAAATGAGCGTCCCTGACTACATGCAGTGTGCTGAGGACCACCAGACGC
TGCTCGTGGTGGTCCAGCCTGTGGGCATCGTCTCCGAGGAGAACTTCTTCAGGATCTATAAGAGGATTTGCTCTGTGAGTCAGATCAGCG
TGCGGGACTCCCAGCGAGTCCTCTACATCCGCTACAGGCACCACTACCCACCCGAGAACAACGAGTGGGGTGACTTCCAGACCCACCGCA
AAGTCGTGGGCCTCATCACCATCACAGACTGCTTCTCGGCCAAGGACTGGCCACAGACCTTTGAGAAGTTCCACGTGCAGAAGGAGATCT
ACGGCTCCACACTGTATGACTCCCGGCTCTTTGTCTTCGGGCTGCAGGGGGAGATCGTGGAGCAGCCGCGCACCGACGTGGCTTTCTACC
CCAACTACGAGGACTGCCAGACGGTGGAGAAGAGAATCGAGGACTTCATCGAGTCACTGTTCATCGTGCTGGAGTCCAAGCGTCTGGACA
GAGCCACAGACAAGTCTGGGGATAAGATCCCCCTTCTCTGTGTCCCGTTTGAGAAAAAGGACTTTGTAGGACTGGACACAGACAGCAGAC
ATTACAAGAAGCGGTGCCAAGGCCGCATGCGGAAGCACGTGGGGGACCTGTGCCTGCAGGCAGGGATGCTGCAGGACTCCCTGGTGCATT
ACCACATGTCGGTGGAGCTGCTGCGTTCTGTGAATGACTTTCTGTGGCTTGGAGCTGCCCTGGAAGGATTGTGTTCAGCTTCTGTCATCT
ATCACTATCCTGGTGGAACTGGTGGGAAGAGTGGAGCTCGGAGGTTCCAGGGCAGCACCCTTCCTGCTGAAGCAGCCAATAGACACCGGC
CAGGTGCCCTCACCACCAATGGCATCAACCCTGACACCAGTACTGAGATCGGACGTGCTAAGAACTGCCTTAGCCCTGAAGACATAATTG
ACAAGTATAAAGAGGCGATTTCCTATTACAGCAAGTATAAGAATGCGGGAGTGATTGAGTTGGAAGCGTGCATCAAGGCTGTACGTGTCC
TTGCAATTCAGAAACGGAGCATGGAAGCATCAGAATTTCTTCAGAATGCAGTTTACATTAACCTTCGACAGCTTTCTGAGGAAGAGAAAA
TTCAGCGCTACAGCATCCTCTCCGAGCTCTATGAGCTGATCGGCTTCCATCGCAAGTCTGCGTTCTTCAAGCGCGTGGCCGCCATGCAGT
GCGTGGCCCCAAGCATCGCGGAGCCTGGGTGGAGGGCCTGCTACAAACTCCTCCTGGAAACGCTGCCCGGCTACAGTCTGTCGCTGGATC
CCAAAGATTTCAGCAGAGGCACGCACAGAGGCTGGGCTGCGGTCCAGATGCGTTTGCTCCATGAATTGGTCTACGCCTCCCGAAGGATGG
GGAACCCTGCCCTCTCTGTCAGACACCTGTCCTTCCTTCTACAGACCATGCTGGACTTCTTGTCGGATCAGGAAAAGAAAGATGTGGCCC
AAAGCCTAGAGAACTATACGTCCAAGTGTCCTGGGACCATGGAGCCCATCGCCCTCCCTGGCGGCCTCACCCTGCCACCGGTGCCCTTCA
CCAAGCTTCCCATCGTCAGGCATGTGAAACTATTGAACCTTCCTGCTAGCCTCCGGCCACACAAAATGAAAAGCTTGCTGGGTCAGAACG
TGTCAACCAAAAGTCCTTTCATCTATTCACCAATTATCGCACACAACCGTGGAGAAGAGCGGAACAAGAAAATAGATTTCCAGTGGGTTC
AAGGAGATGTGTGTGAAGTTCAGCTGATGGTATATAACCCAATGCCGTTTGAACTTCGAGTTGAAAACATGGGGCTGCTCACCAGCGGAG
TGGAGTTCGAGTCTCTCCCTGCGGCGCTTTCTCTTCCGGCTGAATCTGGTCTGTACCCAGTGACGCTCGTCGGGGTCCCGCAGACGACTG
GAACGATTACTGTGAACGGTTACCATACCACGGTCTTCGGTGTGTTCAGTGACTGTTTGCTGGATAACCTGCCGGGAATAAAAACCAGTG
GCTCCACAGTGGAAGTCATTCCCGCGTTGCCAAGACTGCAGATCAGCACCTCTCTGCCCAGATCTGCACATTCATTGCAACCTTCTTCTG
GTGATGAAATATCTACTAATGTATCTGTCCAGCTTTACAATGGAGAAAGTCAGCAACTAATCATTAAATTGGAAAATATTGGAATGGAAC
CATTGGAGAAACTGGAGGTCACCTCGAAAGTTCTCACCACTAAAGAAAAATTGTATGGCGACTTCTTGAGCTGGAAGCTAGAGGAAACCC
TTGCCCAGTTCCCTTTGCAGCCTGGGAAGGTGGCCACGTTCACAATCAACATCAAAGTGAAGCTGGATTTCTCCTGCCAGGAGAATCTCC
TGCAGGATCTCAGTGATGATGGAATCAGTGTGAGTGGCTTTCCCCTGTCCAGTCCTTTTCGGCAGGTCGTTCGGCCCCGAGTGGAGGGCA
AACCTGTGAACCCACCCGAGAGCAACAAAGCAGGCGACTACAGCCACGTGAAGACCCTGGAAGCTGTCCTGAATTTCAAATACTCTGGAG
GCCCGGGCCACACTGAAGGATATTACAGGAATCTCTCCCTGGGGCTGCATGTAGAAGTCGAGCCGTCTGTATTTTTCACCCGAGTCAGCA
CCCTCCCAGCAACCAGTACCCGGCAGTGTCACCTGCTCCTGGATGTCTTCAACTCCACCGAGCATGAGCTGACCGTCAGCACCAGGAGCA
GCGAGGCACTCATCCTGCACGCCGGCGAGTGCCAGCGAATGGCTATTCAAGTGGACAAGTTCAACTTTGAGAGTTTCCCGGAGTCCCCTG
GGGAGAAGGGGCAATTTGCAAACCCCAAGCAGCTGGAGGAAGAGCGGCGGGAAGCCCGAGGCCTGGAGATCCACAGCAAGCTGGGCATCT
GCTGGAGAATCCCCTCCCTGAAGCGCAGTGGCGAGGCGAGTGTGGAAGGACTCCTGAACCAGCTCGTCCTGGAGCACCTGCAGCTGGCGC
CTCTGCAGTGGGGTTATGGGCACGCTGCACCTGGCACCGATGCGGGCAAGGCCTTCTGCATGTTCTACGCCGTGCTGGGCATCCCGCTGA
CACTGGTCATGTTCCAGAGCCTGGGCGAGCGCATGAACACCTTCGTGCGCTACCTGCTGAAGCGCATTAAGAAGTGCTGTGGCATGCGCA
ACACTGACGTGTCTATGGAGAACATGGTGACTGTGGGCTTCTTCTCCTGCATGGGGACGCTGTGCATCGGGGCGGCCGCCTTCTCCCAGT
GTGAGGAGTGGAGCTTCTTCCACGCCTACTACTACTGCTTCATCACGTTGACTACCATTGGGTTCGGGGACTACGTGGCCCTGCAGACCA
AGGGTGCCCTGCAGAAGAAGCCGCTCTACGTGGCCTTTAGCTTTATGTATATCCTGGTGGGGCTGACGGTCATCGGGGCCTTCCTCAACC
TGGTCGTCCTCAGGTTCTTGACCATGAACAGTGAGGATGAGCGGCGGGATGCTGAAGAGAGGGCATCCCTCGCCGGAAACCGCAACAGCA
TGGTCATTCACATCCCTGAGGAGCCGCGGCCCAGCCGGCCCAGGTACAAGGCGGACGTCCCGGACCTGCAGTCTGTGTGCTCCTGCACCT
GCTACCGCTCGCAGGACTATGGCGGCCGCTCGGTGGCACCGCAGAACTCCTTCAGCGCCAAGCTTGCCCCCCACTACTTCCACTCCATCT
CTTACAAGATCGAGGAGATCTCACCAAGCACATTAAAAAACAGCCTCTTCCCATCGCCTATTAGCTCCATCTCTCCTGGGTTACACAGCT
TTACCGACCACCAGAGGCTGATGAAACGCCGGAAGTCCGTTTAGGGGAACTAACTGCACATTCAAGAGAGGCGTCCGTGGATGCTGGGTC

>93847_93847_1_TRAPPC9-KCNK9_TRAPPC9_chr8_140898123_ENST00000389327_KCNK9_chr8_140631342_ENST00000303015_length(amino acids)=1320AA_BP=1
MGSGRRGCSAPLPARSWAPAPGPGPPAVDFKMSVPDYMQCAEDHQTLLVVVQPVGIVSEENFFRIYKRICSVSQISVRDSQRVLYIRYRH
HYPPENNEWGDFQTHRKVVGLITITDCFSAKDWPQTFEKFHVQKEIYGSTLYDSRLFVFGLQGEIVEQPRTDVAFYPNYEDCQTVEKRIE
DFIESLFIVLESKRLDRATDKSGDKIPLLCVPFEKKDFVGLDTDSRHYKKRCQGRMRKHVGDLCLQAGMLQDSLVHYHMSVELLRSVNDF
LWLGAALEGLCSASVIYHYPGGTGGKSGARRFQGSTLPAEAANRHRPGALTTNGINPDTSTEIGRAKNCLSPEDIIDKYKEAISYYSKYK
NAGVIELEACIKAVRVLAIQKRSMEASEFLQNAVYINLRQLSEEEKIQRYSILSELYELIGFHRKSAFFKRVAAMQCVAPSIAEPGWRAC
YKLLLETLPGYSLSLDPKDFSRGTHRGWAAVQMRLLHELVYASRRMGNPALSVRHLSFLLQTMLDFLSDQEKKDVAQSLENYTSKCPGTM
EPIALPGGLTLPPVPFTKLPIVRHVKLLNLPASLRPHKMKSLLGQNVSTKSPFIYSPIIAHNRGEERNKKIDFQWVQGDVCEVQLMVYNP
MPFELRVENMGLLTSGVEFESLPAALSLPAESGLYPVTLVGVPQTTGTITVNGYHTTVFGVFSDCLLDNLPGIKTSGSTVEVIPALPRLQ
ISTSLPRSAHSLQPSSGDEISTNVSVQLYNGESQQLIIKLENIGMEPLEKLEVTSKVLTTKEKLYGDFLSWKLEETLAQFPLQPGKVATF
TINIKVKLDFSCQENLLQDLSDDGISVSGFPLSSPFRQVVRPRVEGKPVNPPESNKAGDYSHVKTLEAVLNFKYSGGPGHTEGYYRNLSL
GLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVSTRSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEE
ERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQLAPLQWGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNT
FVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFS
FMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAP

--------------------------------------------------------------
>93847_93847_2_TRAPPC9-KCNK9_TRAPPC9_chr8_140898123_ENST00000389328_KCNK9_chr8_140631342_ENST00000303015_length(transcript)=4320nt_BP=3364nt
AAAGTCGGGAGTGCCATGGTGCCAGCTGGGGATCAAGACCGCGCGCCACACAGGGGGAAGCCGGCCCAGGCTGGGGCTCGCACCTCACGT
GCCTCCCGGGCCCTGCGATCCTGGAGGCGCTCCCAGGCCGCGCGCGCCACGGTCACCCACCCACGTGGGGGGCACGACCGTGGGAGTCAC
GGGGGGTACCGTGAGGGTCACAGGGGGTGCCGCAGGGATCCACAGTGGGCTTCCGCGGGGCCTCCACCCCTGAGCTTCACAGAGGAAGTG
AAATTTGAGCTGCGCGCCCTGAAGGACTGGGACTTCAAAATGAGCGTCCCTGACTACATGCAGTGTGCTGAGGACCACCAGACGCTGCTC
GTGGTGGTCCAGCCTGTGGGCATCGTCTCCGAGGAGAACTTCTTCAGGATCTATAAGAGGATTTGCTCTGTGAGTCAGATCAGCGTGCGG
GACTCCCAGCGAGTCCTCTACATCCGCTACAGGCACCACTACCCACCCGAGAACAACGAGTGGGGTGACTTCCAGACCCACCGCAAAGTC
GTGGGCCTCATCACCATCACAGACTGCTTCTCGGCCAAGGACTGGCCACAGACCTTTGAGAAGTTCCACGTGCAGAAGGAGATCTACGGC
TCCACACTGTATGACTCCCGGCTCTTTGTCTTCGGGCTGCAGGGGGAGATCGTGGAGCAGCCGCGCACCGACGTGGCTTTCTACCCCAAC
TACGAGGACTGCCAGACGGTGGAGAAGAGAATCGAGGACTTCATCGAGTCACTGTTCATCGTGCTGGAGTCCAAGCGTCTGGACAGAGCC
ACAGACAAGTCTGGGGATAAGATCCCCCTTCTCTGTGTCCCGTTTGAGAAAAAGGACTTTGTAGGACTGGACACAGACAGCAGACATTAC
AAGAAGCGGTGCCAAGGCCGCATGCGGAAGCACGTGGGGGACCTGTGCCTGCAGGCAGGGATGCTGCAGGACTCCCTGGTGCATTACCAC
ATGTCGGTGGAGCTGCTGCGTTCTGTGAATGACTTTCTGTGGCTTGGAGCTGCCCTGGAAGGATTGTGTTCAGCTTCTGTCATCTATCAC
TATCCTGGTGGAACTGGTGGGAAGAGTGGAGCTCGGAGGTTCCAGGGCAGCACCCTTCCTGCTGAAGCAGCCAATAGACACCGGCCAGGG
GCACAGGAAGTTCTCATTGATCCAGGTGCCCTCACCACCAATGGCATCAACCCTGACACCAGTACTGAGATCGGACGTGCTAAGAACTGC
CTTAGCCCTGAAGACATAATTGACAAGTATAAAGAGGCGATTTCCTATTACAGCAAGTATAAGAATGCGGGAGTGATTGAGTTGGAAGCG
TGCATCAAGGCTGTACGTGTCCTTGCAATTCAGAAACGGAGCATGGAAGCATCAGAATTTCTTCAGAATGCAGTTTACATTAACCTTCGA
CAGCTTTCTGAGGAAGAGAAAATTCAGCGCTACAGCATCCTCTCCGAGCTCTATGAGCTGATCGGCTTCCATCGCAAGTCTGCGTTCTTC
AAGCGCGTGGCCGCCATGCAGTGCGTGGCCCCAAGCATCGCGGAGCCTGGGTGGAGGGCCTGCTACAAACTCCTCCTGGAAACGCTGCCC
GGCTACAGTCTGTCGCTGGATCCCAAAGATTTCAGCAGAGGCACGCACAGAGGCTGGGCTGCGGTCCAGATGCGTTTGCTCCATGAATTG
GTCTACGCCTCCCGAAGGATGGGGAACCCTGCCCTCTCTGTCAGACACCTGTCCTTCCTTCTACAGACCATGCTGGACTTCTTGTCGGAT
CAGGAAAAGAAAGATGTGGCCCAAAGCCTAGAGAACTATACGTCCAAGTGTCCTGGGACCATGGAGCCCATCGCCCTCCCTGGCGGCCTC
ACCCTGCCACCGGTGCCCTTCACCAAGCTTCCCATCGTCAGGCATGTGAAACTATTGAACCTTCCTGCTAGCCTCCGGCCACACAAAATG
AAAAGCTTGCTGGGTCAGAACGTGTCAACCAAAAGTCCTTTCATCTATTCACCAATTATCGCACACAACCGTGGAGAAGAGCGGAACAAG
AAAATAGATTTCCAGTGGGTTCAAGGAGATGTGTGTGAAGTTCAGCTGATGGTATATAACCCAATGCCGTTTGAACTTCGAGTTGAAAAC
ATGGGGCTGCTCACCAGCGGAGTGGAGTTCGAGTCTCTCCCTGCGGCGCTTTCTCTTCCGGCTGAATCTGGTCTGTACCCAGTGACGCTC
GTCGGGGTCCCGCAGACGACTGGAACGATTACTGTGAACGGTTACCATACCACGGTCTTCGGTGTGTTCAGTGACTGTTTGCTGGATAAC
CTGCCGGGAATAAAAACCAGTGGCTCCACAGTGGAAGTCATTCCCGCGTTGCCAAGACTGCAGATCAGCACCTCTCTGCCCAGATCTGCA
CATTCATTGCAACCTTCTTCTGGTGATGAAATATCTACTAATGTATCTGTCCAGCTTTACAATGGAGAAAGTCAGCAACTAATCATTAAA
TTGGAAAATATTGGAATGGAACCATTGGAGAAACTGGAGGTCACCTCGAAAGTTCTCACCACTAAAGAAAAATTGTATGGCGACTTCTTG
AGCTGGAAGCTAGAGGAAACCCTTGCCCAGTTCCCTTTGCAGCCTGGGAAGGTGGCCACGTTCACAATCAACATCAAAGTGAAGCTGGAT
TTCTCCTGCCAGGAGAATCTCCTGCAGGATCTCAGTGATGATGGAATCAGTGTGAGTGGCTTTCCCCTGTCCAGTCCTTTTCGGCAGGTC
GTTCGGCCCCGAGTGGAGGGCAAACCTGTGAACCCACCCGAGAGCAACAAAGCAGGCGACTACAGCCACGTGAAGACCCTGGAAGCTGTC
CTGAATTTCAAATACTCTGGAGGCCCGGGCCACACTGAAGGATATTACAGGAATCTCTCCCTGGGGCTGCATGTAGAAGTCGAGCCGTCT
GTATTTTTCACCCGAGTCAGCACCCTCCCAGCAACCAGTACCCGGCAGTGTCACCTGCTCCTGGATGTCTTCAACTCCACCGAGCATGAG
CTGACCGTCAGCACCAGGAGCAGCGAGGCACTCATCCTGCACGCCGGCGAGTGCCAGCGAATGGCTATTCAAGTGGACAAGTTCAACTTT
GAGAGTTTCCCGGAGTCCCCTGGGGAGAAGGGGCAATTTGCAAACCCCAAGCAGCTGGAGGAAGAGCGGCGGGAAGCCCGAGGCCTGGAG
ATCCACAGCAAGCTGGGCATCTGCTGGAGAATCCCCTCCCTGAAGCGCAGTGGCGAGGCGAGTGTGGAAGGACTCCTGAACCAGCTCGTC
CTGGAGCACCTGCAGCTGGCGCCTCTGCAGTGGGGTTATGGGCACGCTGCACCTGGCACCGATGCGGGCAAGGCCTTCTGCATGTTCTAC
GCCGTGCTGGGCATCCCGCTGACACTGGTCATGTTCCAGAGCCTGGGCGAGCGCATGAACACCTTCGTGCGCTACCTGCTGAAGCGCATT
AAGAAGTGCTGTGGCATGCGCAACACTGACGTGTCTATGGAGAACATGGTGACTGTGGGCTTCTTCTCCTGCATGGGGACGCTGTGCATC
GGGGCGGCCGCCTTCTCCCAGTGTGAGGAGTGGAGCTTCTTCCACGCCTACTACTACTGCTTCATCACGTTGACTACCATTGGGTTCGGG
GACTACGTGGCCCTGCAGACCAAGGGTGCCCTGCAGAAGAAGCCGCTCTACGTGGCCTTTAGCTTTATGTATATCCTGGTGGGGCTGACG
GTCATCGGGGCCTTCCTCAACCTGGTCGTCCTCAGGTTCTTGACCATGAACAGTGAGGATGAGCGGCGGGATGCTGAAGAGAGGGCATCC
CTCGCCGGAAACCGCAACAGCATGGTCATTCACATCCCTGAGGAGCCGCGGCCCAGCCGGCCCAGGTACAAGGCGGACGTCCCGGACCTG
CAGTCTGTGTGCTCCTGCACCTGCTACCGCTCGCAGGACTATGGCGGCCGCTCGGTGGCACCGCAGAACTCCTTCAGCGCCAAGCTTGCC
CCCCACTACTTCCACTCCATCTCTTACAAGATCGAGGAGATCTCACCAAGCACATTAAAAAACAGCCTCTTCCCATCGCCTATTAGCTCC
ATCTCTCCTGGGTTACACAGCTTTACCGACCACCAGAGGCTGATGAAACGCCGGAAGTCCGTTTAGGGGAACTAACTGCACATTCAAGAG
AGGCGTCCGTGGATGCTGGGTCTCACTGCCAAAGCCGAACACGGCTTCGGGATTTCTGCCTTCTCAAGTGGACCTCTGCTGTGCTGGGCG

>93847_93847_2_TRAPPC9-KCNK9_TRAPPC9_chr8_140898123_ENST00000389328_KCNK9_chr8_140631342_ENST00000303015_length(amino acids)=1396AA_BP=0
MVPAGDQDRAPHRGKPAQAGARTSRASRALRSWRRSQAARATVTHPRGGHDRGSHGGYREGHRGCRRDPQWASAGPPPLSFTEEVKFELR
ALKDWDFKMSVPDYMQCAEDHQTLLVVVQPVGIVSEENFFRIYKRICSVSQISVRDSQRVLYIRYRHHYPPENNEWGDFQTHRKVVGLIT
ITDCFSAKDWPQTFEKFHVQKEIYGSTLYDSRLFVFGLQGEIVEQPRTDVAFYPNYEDCQTVEKRIEDFIESLFIVLESKRLDRATDKSG
DKIPLLCVPFEKKDFVGLDTDSRHYKKRCQGRMRKHVGDLCLQAGMLQDSLVHYHMSVELLRSVNDFLWLGAALEGLCSASVIYHYPGGT
GGKSGARRFQGSTLPAEAANRHRPGAQEVLIDPGALTTNGINPDTSTEIGRAKNCLSPEDIIDKYKEAISYYSKYKNAGVIELEACIKAV
RVLAIQKRSMEASEFLQNAVYINLRQLSEEEKIQRYSILSELYELIGFHRKSAFFKRVAAMQCVAPSIAEPGWRACYKLLLETLPGYSLS
LDPKDFSRGTHRGWAAVQMRLLHELVYASRRMGNPALSVRHLSFLLQTMLDFLSDQEKKDVAQSLENYTSKCPGTMEPIALPGGLTLPPV
PFTKLPIVRHVKLLNLPASLRPHKMKSLLGQNVSTKSPFIYSPIIAHNRGEERNKKIDFQWVQGDVCEVQLMVYNPMPFELRVENMGLLT
SGVEFESLPAALSLPAESGLYPVTLVGVPQTTGTITVNGYHTTVFGVFSDCLLDNLPGIKTSGSTVEVIPALPRLQISTSLPRSAHSLQP
SSGDEISTNVSVQLYNGESQQLIIKLENIGMEPLEKLEVTSKVLTTKEKLYGDFLSWKLEETLAQFPLQPGKVATFTINIKVKLDFSCQE
NLLQDLSDDGISVSGFPLSSPFRQVVRPRVEGKPVNPPESNKAGDYSHVKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTR
VSTLPATSTRQCHLLLDVFNSTEHELTVSTRSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKL
GICWRIPSLKRSGEASVEGLLNQLVLEHLQLAPLQWGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCG
MRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAF
LNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFH

--------------------------------------------------------------
>93847_93847_3_TRAPPC9-KCNK9_TRAPPC9_chr8_140898123_ENST00000438773_KCNK9_chr8_140631342_ENST00000303015_length(transcript)=4145nt_BP=3189nt
AGCGCCGGCTCGGCCGCCAGTAGGAAGCGCCAGCCCAGAGCCTGGGAAGTGGCCGCAGAGGCTGCTCGGCCCCGCTGCCCGCCAGGTCGT
GGGCTCCCGCTCCGGGCCCGGGGCCACCGGCTGTGGACTTCAAAATGAGCGTCCCTGACTACATGCAGTGTGCTGAGGACCACCAGACGC
TGCTCGTGGTGGTCCAGCCTGTGGGCATCGTCTCCGAGGAGAACTTCTTCAGGATCTATAAGAGGATTTGCTCTGTGAGTCAGATCAGCG
TGCGGGACTCCCAGCGAGTCCTCTACATCCGCTACAGGCACCACTACCCACCCGAGAACAACGAGTGGGGTGACTTCCAGACCCACCGCA
AAGTCGTGGGCCTCATCACCATCACAGACTGCTTCTCGGCCAAGGACTGGCCACAGACCTTTGAGAAGTTCCACGTGCAGAAGGAGATCT
ACGGCTCCACACTGTATGACTCCCGGCTCTTTGTCTTCGGGCTGCAGGGGGAGATCGTGGAGCAGCCGCGCACCGACGTGGCTTTCTACC
CCAACTACGAGGACTGCCAGACGGTGGAGAAGAGAATCGAGGACTTCATCGAGTCACTGTTCATCGTGCTGGAGTCCAAGCGTCTGGACA
GAGCCACAGACAAGTCTGGGGATAAGATCCCCCTTCTCTGTGTCCCGTTTGAGAAAAAGGACTTTGTAGGACTGGACACAGACAGCAGAC
ATTACAAGAAGCGGTGCCAAGGCCGCATGCGGAAGCACGTGGGGGACCTGTGCCTGCAGGCAGGGATGCTGCAGGACTCCCTGGTGCATT
ACCACATGTCGGTGGAGCTGCTGCGTTCTGTGAATGACTTTCTGTGGCTTGGAGCTGCCCTGGAAGGATTGTGTTCAGCTTCTGTCATCT
ATCACTATCCTGGTGGAACTGGTGGGAAGAGTGGAGCTCGGAGGTTCCAGGGCAGCACCCTTCCTGCTGAAGCAGCCAATAGACACCGGC
CAGGGGCACAGGAAGTTCTCATTGATCCAGGTGCCCTCACCACCAATGGCATCAACCCTGACACCAGTACTGAGATCGGACGTGCTAAGA
ACTGCCTTAGCCCTGAAGACATAATTGACAAGTATAAAGAGGCGATTTCCTATTACAGCAAGTATAAGAATGCGGGAGTGATTGAGTTGG
AAGCGTGCATCAAGGCTGTACGTGTCCTTGCAATTCAGAAACGGAGCATGGAAGCATCAGAATTTCTTCAGAATGCAGTTTACATTAACC
TTCGACAGCTTTCTGAGGAAGAGAAAATTCAGCGCTACAGCATCCTCTCCGAGCTCTATGAGCTGATCGGCTTCCATCGCAAGTCTGCGT
TCTTCAAGCGCGTGGCCGCCATGCAGTGCGTGGCCCCAAGCATCGCGGAGCCTGGGTGGAGGGCCTGCTACAAACTCCTCCTGGAAACGC
TGCCCGGCTACAGTCTGTCGCTGGATCCCAAAGATTTCAGCAGAGGCACGCACAGAGGCTGGGCTGCGGTCCAGATGCGTTTGCTCCATG
AATTGGTCTACGCCTCCCGAAGGATGGGGAACCCTGCCCTCTCTGTCAGACACCTGTCCTTCCTTCTACAGACCATGCTGGACTTCTTGT
CGGATCAGGAAAAGAAAGATGTGGCCCAAAGCCTAGAGAACTATACGTCCAAGTGTCCTGGGACCATGGAGCCCATCGCCCTCCCTGGCG
GCCTCACCCTGCCACCGGTGCCCTTCACCAAGCTTCCCATCGTCAGGCATGTGAAACTATTGAACCTTCCTGCTAGCCTCCGGCCACACA
AAATGAAAAGCTTGCTGGGTCAGAACGTGTCAACCAAAAGTCCTTTCATCTATTCACCAATTATCGCACACAACCGTGGAGAAGAGCGGA
ACAAGAAAATAGATTTCCAGTGGGTTCAAGGAGATGTGTGTGAAGTTCAGCTGATGGTATATAACCCAATGCCGTTTGAACTTCGAGTTG
AAAACATGGGGCTGCTCACCAGCGGAGTGGAGTTCGAGTCTCTCCCTGCGGCGCTTTCTCTTCCGGCTGAATCTGGTCTGTACCCAGTGA
CGCTCGTCGGGGTCCCGCAGACGACTGGAACGATTACTGTGAACGGTTACCATACCACGGTCTTCGGTGTGTTCAGTGACTGTTTGCTGG
ATAACCTGCCGGGAATAAAAACCAGTGGCTCCACAGTGGAAGTCATTCCCGCGTTGCCAAGACTGCAGATCAGCACCTCTCTGCCCAGAT
CTGCACATTCATTGCAACCTTCTTCTGGTGATGAAATATCTACTAATGTATCTGTCCAGCTTTACAATGGAGAAAGTCAGCAACTAATCA
TTAAATTGGAAAATATTGGAATGGAACCATTGGAGAAACTGGAGGTCACCTCGAAAGTTCTCACCACTAAAGAAAAATTGTATGGCGACT
TCTTGAGCTGGAAGCTAGAGGAAACCCTTGCCCAGTTCCCTTTGCAGCCTGGGAAGGTGGCCACGTTCACAATCAACATCAAAGTGAAGC
TGGATTTCTCCTGCCAGGAGAATCTCCTGCAGGATCTCAGTGATGATGGAATCAGTGTGAGTGGCTTTCCCCTGTCCAGTCCTTTTCGGC
AGGTCGTTCGGCCCCGAGTGGAGGGCAAACCTGTGAACCCACCCGAGAGCAACAAAGCAGGCGACTACAGCCACGTGAAGACCCTGGAAG
CTGTCCTGAATTTCAAATACTCTGGAGGCCCGGGCCACACTGAAGGATATTACAGGAATCTCTCCCTGGGGCTGCATGTAGAAGTCGAGC
CGTCTGTATTTTTCACCCGAGTCAGCACCCTCCCAGCAACCAGTACCCGGCAGTGTCACCTGCTCCTGGATGTCTTCAACTCCACCGAGC
ATGAGCTGACCGTCAGCACCAGGAGCAGCGAGGCACTCATCCTGCACGCCGGCGAGTGCCAGCGAATGGCTATTCAAGTGGACAAGTTCA
ACTTTGAGAGTTTCCCGGAGTCCCCTGGGGAGAAGGGGCAATTTGCAAACCCCAAGCAGCTGGAGGAAGAGCGGCGGGAAGCCCGAGGCC
TGGAGATCCACAGCAAGCTGGGCATCTGCTGGAGAATCCCCTCCCTGAAGCGCAGTGGCGAGGCGAGTGTGGAAGGACTCCTGAACCAGC
TCGTCCTGGAGCACCTGCAGCTGGCGCCTCTGCAGTGGGGTTATGGGCACGCTGCACCTGGCACCGATGCGGGCAAGGCCTTCTGCATGT
TCTACGCCGTGCTGGGCATCCCGCTGACACTGGTCATGTTCCAGAGCCTGGGCGAGCGCATGAACACCTTCGTGCGCTACCTGCTGAAGC
GCATTAAGAAGTGCTGTGGCATGCGCAACACTGACGTGTCTATGGAGAACATGGTGACTGTGGGCTTCTTCTCCTGCATGGGGACGCTGT
GCATCGGGGCGGCCGCCTTCTCCCAGTGTGAGGAGTGGAGCTTCTTCCACGCCTACTACTACTGCTTCATCACGTTGACTACCATTGGGT
TCGGGGACTACGTGGCCCTGCAGACCAAGGGTGCCCTGCAGAAGAAGCCGCTCTACGTGGCCTTTAGCTTTATGTATATCCTGGTGGGGC
TGACGGTCATCGGGGCCTTCCTCAACCTGGTCGTCCTCAGGTTCTTGACCATGAACAGTGAGGATGAGCGGCGGGATGCTGAAGAGAGGG
CATCCCTCGCCGGAAACCGCAACAGCATGGTCATTCACATCCCTGAGGAGCCGCGGCCCAGCCGGCCCAGGTACAAGGCGGACGTCCCGG
ACCTGCAGTCTGTGTGCTCCTGCACCTGCTACCGCTCGCAGGACTATGGCGGCCGCTCGGTGGCACCGCAGAACTCCTTCAGCGCCAAGC
TTGCCCCCCACTACTTCCACTCCATCTCTTACAAGATCGAGGAGATCTCACCAAGCACATTAAAAAACAGCCTCTTCCCATCGCCTATTA
GCTCCATCTCTCCTGGGTTACACAGCTTTACCGACCACCAGAGGCTGATGAAACGCCGGAAGTCCGTTTAGGGGAACTAACTGCACATTC
AAGAGAGGCGTCCGTGGATGCTGGGTCTCACTGCCAAAGCCGAACACGGCTTCGGGATTTCTGCCTTCTCAAGTGGACCTCTGCTGTGCT

>93847_93847_3_TRAPPC9-KCNK9_TRAPPC9_chr8_140898123_ENST00000438773_KCNK9_chr8_140631342_ENST00000303015_length(amino acids)=1329AA_BP=1
MGSGRRGCSAPLPARSWAPAPGPGPPAVDFKMSVPDYMQCAEDHQTLLVVVQPVGIVSEENFFRIYKRICSVSQISVRDSQRVLYIRYRH
HYPPENNEWGDFQTHRKVVGLITITDCFSAKDWPQTFEKFHVQKEIYGSTLYDSRLFVFGLQGEIVEQPRTDVAFYPNYEDCQTVEKRIE
DFIESLFIVLESKRLDRATDKSGDKIPLLCVPFEKKDFVGLDTDSRHYKKRCQGRMRKHVGDLCLQAGMLQDSLVHYHMSVELLRSVNDF
LWLGAALEGLCSASVIYHYPGGTGGKSGARRFQGSTLPAEAANRHRPGAQEVLIDPGALTTNGINPDTSTEIGRAKNCLSPEDIIDKYKE
AISYYSKYKNAGVIELEACIKAVRVLAIQKRSMEASEFLQNAVYINLRQLSEEEKIQRYSILSELYELIGFHRKSAFFKRVAAMQCVAPS
IAEPGWRACYKLLLETLPGYSLSLDPKDFSRGTHRGWAAVQMRLLHELVYASRRMGNPALSVRHLSFLLQTMLDFLSDQEKKDVAQSLEN
YTSKCPGTMEPIALPGGLTLPPVPFTKLPIVRHVKLLNLPASLRPHKMKSLLGQNVSTKSPFIYSPIIAHNRGEERNKKIDFQWVQGDVC
EVQLMVYNPMPFELRVENMGLLTSGVEFESLPAALSLPAESGLYPVTLVGVPQTTGTITVNGYHTTVFGVFSDCLLDNLPGIKTSGSTVE
VIPALPRLQISTSLPRSAHSLQPSSGDEISTNVSVQLYNGESQQLIIKLENIGMEPLEKLEVTSKVLTTKEKLYGDFLSWKLEETLAQFP
LQPGKVATFTINIKVKLDFSCQENLLQDLSDDGISVSGFPLSSPFRQVVRPRVEGKPVNPPESNKAGDYSHVKTLEAVLNFKYSGGPGHT
EGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVSTRSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQ
FANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQLAPLQWGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMF
QSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQ
KKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TRAPPC9-KCNK9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TRAPPC9-KCNK9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TRAPPC9-KCNK9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source