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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AARSD1-FBXL20 (FusionGDB2 ID:94)

Fusion Gene Summary for AARSD1-FBXL20

Fusion gene summary

Fusion gene information	Fusion gene name: AARSD1-FBXL20
	Fusion gene ID: 94
		Hgene	Tgene
	Gene symbol	AARSD1	FBXL20
	Gene ID	80755	84961
	Gene name	alanyl-tRNA synthetase domain containing 1	F-box and leucine rich repeat protein 20
	Synonyms	-	Fbl2\|Fbl20
	Cytomap	17q21.31	17q12
	Type of gene	protein-coding	protein-coding
	Description	alanyl-tRNA editing protein Aarsd1alanyl-tRNA synthetase domain-containing protein 1	F-box/LRR-repeat protein 20F-box protein FBL2
	Modification date	20200313	20200313
	UniProtAcc	.	Q96IG2
	Ensembl transtripts involved in fusion gene	ENST00000427569, ENST00000416949,	ENST00000264658, ENST00000394294, ENST00000577399, ENST00000583610,
Fusion gene scores	* DoF score	4 X 6 X 4=96	13 X 9 X 6=702
	# samples	6	17
	** MAII score	log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/702*10)=-2.04593628416686 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AARSD1 [Title/Abstract] AND FBXL20 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AARSD1(41108221)-FBXL20(37499494), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across AARSD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FBXL20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-BT-A2LA-01A	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-

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Fusion Gene ORF analysis for AARSD1-FBXL20

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000427569	ENST00000264658	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-
In-frame	ENST00000427569	ENST00000394294	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-
In-frame	ENST00000427569	ENST00000577399	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-
In-frame	ENST00000427569	ENST00000583610	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-
intron-3CDS	ENST00000416949	ENST00000264658	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-
intron-3CDS	ENST00000416949	ENST00000394294	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-
intron-3CDS	ENST00000416949	ENST00000577399	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-
intron-3CDS	ENST00000416949	ENST00000583610	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000427569	AARSD1	chr17	41108221	-	ENST00000583610	FBXL20	chr17	37499494	-	2142	699	36	1967	643
ENST00000427569	AARSD1	chr17	41108221	-	ENST00000394294	FBXL20	chr17	37499494	-	2745	699	36	1871	611
ENST00000427569	AARSD1	chr17	41108221	-	ENST00000264658	FBXL20	chr17	37499494	-	2841	699	36	1967	643
ENST00000427569	AARSD1	chr17	41108221	-	ENST00000577399	FBXL20	chr17	37499494	-	1968	699	36	1967	643

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000427569	ENST00000583610	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-	0.004886097	0.9951139
ENST00000427569	ENST00000394294	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-	0.001750525	0.9982495
ENST00000427569	ENST00000264658	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-	0.001533678	0.9984664
ENST00000427569	ENST00000577399	AARSD1	chr17	41108221	-	FBXL20	chr17	37499494	-	0.005328704	0.9946713

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Fusion Genomic Features for AARSD1-FBXL20

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AARSD1-FBXL20

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:41108221/chr17:37499494)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FBXL20 Q96IG2
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

22_68

437.0

Domain

F-box

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

22_68

405.0

Domain

F-box

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

22_68

411.6666666666667

Domain

F-box

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

101_126

437.0

Repeat

Note=LRR 2

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

127_152

437.0

Repeat

Note=LRR 3

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

153_178

437.0

Repeat

Note=LRR 4

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

179_204

437.0

Repeat

Note=LRR 5

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

205_230

437.0

Repeat

Note=LRR 6

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

231_256

437.0

Repeat

Note=LRR 7

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

257_282

437.0

Repeat

Note=LRR 8

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

283_308

437.0

Repeat

Note=LRR 9

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

309_334

437.0

Repeat

Note=LRR 10

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

335_363

437.0

Repeat

Note=LRR 11

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

364_388

437.0

Repeat

Note=LRR 12

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

389_414

437.0

Repeat

Note=LRR 13

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000264658

74_100

437.0

Repeat

Note=LRR 1

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

101_126

405.0

Repeat

Note=LRR 2

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

127_152

405.0

Repeat

Note=LRR 3

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

153_178

405.0

Repeat

Note=LRR 4

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

179_204

405.0

Repeat

Note=LRR 5

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

205_230

405.0

Repeat

Note=LRR 6

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

231_256

405.0

Repeat

Note=LRR 7

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

257_282

405.0

Repeat

Note=LRR 8

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

283_308

405.0

Repeat

Note=LRR 9

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

309_334

405.0

Repeat

Note=LRR 10

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

335_363

405.0

Repeat

Note=LRR 11

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

364_388

405.0

Repeat

Note=LRR 12

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

389_414

405.0

Repeat

Note=LRR 13

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000394294

74_100

405.0

Repeat

Note=LRR 1

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

101_126

411.6666666666667

Repeat

Note=LRR 2

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

127_152

411.6666666666667

Repeat

Note=LRR 3

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

153_178

411.6666666666667

Repeat

Note=LRR 4

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

179_204

411.6666666666667

Repeat

Note=LRR 5

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

205_230

411.6666666666667

Repeat

Note=LRR 6

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

231_256

411.6666666666667

Repeat

Note=LRR 7

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

257_282

411.6666666666667

Repeat

Note=LRR 8

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

283_308

411.6666666666667

Repeat

Note=LRR 9

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

309_334

411.6666666666667

Repeat

Note=LRR 10

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

335_363

411.6666666666667

Repeat

Note=LRR 11

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

364_388

411.6666666666667

Repeat

Note=LRR 12

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

389_414

411.6666666666667

Repeat

Note=LRR 13

Tgene

FBXL20

chr17:41108221

chr17:37499494

ENST00000583610

74_100

411.6666666666667

Repeat

Note=LRR 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for AARSD1-FBXL20

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>94_94_1_AARSD1-FBXL20_AARSD1_chr17_41108221_ENST00000427569_FBXL20_chr17_37499494_ENST00000264658_length(transcript)=2841nt_BP=699nt
TTCTCTGCGCGTGCGCCTCCTCACACGCCTGCAGGTATGGCGTTCTGGTGTCAGCGTGACAGTTATGCCCGAGAGTTCACCACCACCGTG
GTCTCCTGCTGTCCCGCGGAGCTGCAGACTGAAGGGAGCAACGGCAAGAAAGAAGTGCTGAGCGGTTTCCAAGTGGTGCTGGAAGACACA
GTGCTTTTCCCTGAGGGCGGGGGACAGCCTGATGACCGTGGTACAATCAATGACATCTCTGTGCTGAGAGTGACTCGCCGTGGGGAACAG
GCTGATCATTTCACCCAGACACCCCTGGATCCAGGAAGCCAGGTTCTGGTCCGGGTAGATTGGGAGCGGAGGTTTGACCACATGCAGCAG
CATTCAGGGCAGCATCTCATCACGGCAGTTGCTGACCATCTATTTAAGCTGAAGACAACATCATGGGAGTTAGGGAGATTTCGGAGTGCG
ATTGAGCTGGACACCCCCTCTATGACTGCAGAGCAAGTAGCTGCCATTGAGCAGAGCGTCAATGAAAAAATCAGAGATCGGCTGCCTGTG
AATGTCCGAGAACTGAGCCTGGATGATCCTGAGGTGGAGCAGGTGAGTGGCCGGGGTTTGCCTGATGATCATGCTGGGCCCATTCGGGTT
GTTAACATCGAGGGCGTTGATTCCAACATGTGCTGTGGGACCCATGTGAGCAATCTCAGTGACCTTCAGATGTTCTCAAATAGTGATGAA
GCTGTAATCAATAAAAAACTTCCCAAAGAACTCCTGTTACGGATATTTTCTTTTCTAGATGTTGTTACCCTGTGCCGCTGTGCTCAGGTC
TCCAGGGCCTGGAATGTTCTGGCTCTGGATGGCAGTAACTGGCAGCGAATTGACCTATTTGATTTCCAGAGGGATATTGAGGGCCGAGTA
GTGGAGAATATTTCAAAACGATGTGGGGGCTTTTTACGAAAGTTAAGTCTTCGTGGATGTCTTGGAGTGGGAGACAATGCATTAAGAACC
TTTGCACAAAACTGCAGGAACATTGAAGTACTGAATCTAAATGGGTGTACAAAGACAACAGACGCTACATGTACTAGCCTTAGCAAGTTC
TGTTCCAAACTCAGGCACCTTGACTTGGCTTCCTGTACATCAATAACAAACATGTCTCTAAAAGCTCTGAGTGAGGGATGTCCACTGTTG
GAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCAAGGCCTTATTC
TTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACTTGCAGACTTGC
TTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCTCCAACATCACA
GATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAGATGTGGGCTTT
ACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAATCCAACTTTCT
ATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGAATGGGGCCTGC
GCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCTGTCATAGCCTT
GAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTAAAGTCCACGCC
TACTTCGCACCTGTCACTCCACCCCCATCAGTAGGGGGCAGCAGACAGCGCTTCTGCAGATGCTGCATCATCCTATGACAATGGAGGTGG
TCAACCTTGGCGAACTGAGTATTTAATGACACTTCTAGAGCTACCGTGGAGTCTCTCCAGTGGAAGCAACCCCAGTGTTCTGAGCAAGGG
TTACAAAGTGAGGGAGGGCAGTGTCCAGATCCCCAGAGCCACACATACATACACATACACACCCTTACCCCCATCCACTCTAGCTTTGTG
ACCATGGGACTGAAGTTTGTGATGGCTTTTTTATCAAGTAGATTGGTAAAATTTAACCATTCCTGTTGAGGTGCCCATAAGAAAATCATA
GGCCAAGATAGGGAGGGGCATTCCAGCAAACCCCGTGTTAATGCTACTGTGGTTTTTAAATTTTTGTCTAGGGGTTTCTTTGGGGATTTT
AGAACAGCATCTGCTGTCCTCCGGGGTCAAGAAAAGCATGGAAAGACAATATATGATGTACCCAGGGACCAGAAAGAAAATTTCTTTGCA
TCTTAGAAATGGTAGACATTCATTGTGACTAAAGAGCTTCTATGCTTCCTTGTTTCCATGCCAACATGCTGAGCATGCTCACAAAGAAGG
CTCGTCCATTCCTCCTGTGTTTTAGTATTTGGCCCAGAGGTTTCCTAAATGGTTGCCTTGAAATCACTGTGGTCCAAATGTAATTCTTAC
ACACTCAAATTATCACTGTCTGTAGCACACTTGTGCACCTGTCTTACATTCTCTGTTGCTCCCCCCCACACTCTTGCTCAGTCTGTCACC
TGTTCAGTCTGCTTACTCACTCAATTGTTACCCTTTTGCTGTTGTCGTGTTTACAGTTTGCATTTTGAATGATTAGTTGGGATTACCAAA

>94_94_1_AARSD1-FBXL20_AARSD1_chr17_41108221_ENST00000427569_FBXL20_chr17_37499494_ENST00000264658_length(amino acids)=643AA_BP=219
MAFWCQRDSYAREFTTTVVSCCPAELQTEGSNGKKEVLSGFQVVLEDTVLFPEGGGQPDDRGTINDISVLRVTRRGEQADHFTQTPLDPG
SQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKTTSWELGRFRSAIELDTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEV
EQVSGRGLPDDHAGPIRVVNIEGVDSNMCCGTHVSNLSDLQMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGS
NWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASC
TSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITIC
RGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLS
HCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVG

--------------------------------------------------------------
>94_94_2_AARSD1-FBXL20_AARSD1_chr17_41108221_ENST00000427569_FBXL20_chr17_37499494_ENST00000394294_length(transcript)=2745nt_BP=699nt
TTCTCTGCGCGTGCGCCTCCTCACACGCCTGCAGGTATGGCGTTCTGGTGTCAGCGTGACAGTTATGCCCGAGAGTTCACCACCACCGTG
GTCTCCTGCTGTCCCGCGGAGCTGCAGACTGAAGGGAGCAACGGCAAGAAAGAAGTGCTGAGCGGTTTCCAAGTGGTGCTGGAAGACACA
GTGCTTTTCCCTGAGGGCGGGGGACAGCCTGATGACCGTGGTACAATCAATGACATCTCTGTGCTGAGAGTGACTCGCCGTGGGGAACAG
GCTGATCATTTCACCCAGACACCCCTGGATCCAGGAAGCCAGGTTCTGGTCCGGGTAGATTGGGAGCGGAGGTTTGACCACATGCAGCAG
CATTCAGGGCAGCATCTCATCACGGCAGTTGCTGACCATCTATTTAAGCTGAAGACAACATCATGGGAGTTAGGGAGATTTCGGAGTGCG
ATTGAGCTGGACACCCCCTCTATGACTGCAGAGCAAGTAGCTGCCATTGAGCAGAGCGTCAATGAAAAAATCAGAGATCGGCTGCCTGTG
AATGTCCGAGAACTGAGCCTGGATGATCCTGAGGTGGAGCAGGTGAGTGGCCGGGGTTTGCCTGATGATCATGCTGGGCCCATTCGGGTT
GTTAACATCGAGGGCGTTGATTCCAACATGTGCTGTGGGACCCATGTGAGCAATCTCAGTGACCTTCAGATGTTCTCAAATAGTGATGAA
GCTGTAATCAATAAAAAACTTCCCAAAGAACTCCTGTTACGGATATTTTCTTTTCTAGATGTTGTTACCCTGTGCCGCTGTGCTCAGGTC
TCCAGGGCCTGGAATGTTCTGGCTCTGGATGGCAGTAACTGGCAGCGAATTGACCTATTTGATTTCCAGAGGGATATTGAGGGCCGAGTA
GTGGAGAATATTTCAAAACGATGTGGGGGCTTTTTACGAAAGTTAAGTCTTCGTGGATGTCTTGGAGTGGGAGACAATGCATTAAGAACC
TTTGCACAAAACTGCAGGAACATTGAAGTACTGAATCTAAATGGGTGTACAAAGACAACAGACGCTGAGGGATGTCCACTGTTGGAGCAG
TTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCAAGGCCTTATTCTTAAAA
GGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACTTGCAGACTTGCTTGCAA
ATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCTCCAACATCACAGATGCC
ATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAGATGTGGGCTTTACCACT
CTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAATCCAACTTTCTATACAC
TGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGAATGGGGCCTGCGCCCAT
GACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCTGTCATAGCCTTGAGCGG
ATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTAAAGTCCACGCCTACTTC
GCACCTGTCACTCCACCCCCATCAGTAGGGGGCAGCAGACAGCGCTTCTGCAGATGCTGCATCATCCTATGACAATGGAGGTGGTCAACC
TTGGCGAACTGAGTATTTAATGACACTTCTAGAGCTACCGTGGAGTCTCTCCAGTGGAAGCAACCCCAGTGTTCTGAGCAAGGGTTACAA
AGTGAGGGAGGGCAGTGTCCAGATCCCCAGAGCCACACATACATACACATACACACCCTTACCCCCATCCACTCTAGCTTTGTGACCATG
GGACTGAAGTTTGTGATGGCTTTTTTATCAAGTAGATTGGTAAAATTTAACCATTCCTGTTGAGGTGCCCATAAGAAAATCATAGGCCAA
GATAGGGAGGGGCATTCCAGCAAACCCCGTGTTAATGCTACTGTGGTTTTTAAATTTTTGTCTAGGGGTTTCTTTGGGGATTTTAGAACA
GCATCTGCTGTCCTCCGGGGTCAAGAAAAGCATGGAAAGACAATATATGATGTACCCAGGGACCAGAAAGAAAATTTCTTTGCATCTTAG
AAATGGTAGACATTCATTGTGACTAAAGAGCTTCTATGCTTCCTTGTTTCCATGCCAACATGCTGAGCATGCTCACAAAGAAGGCTCGTC
CATTCCTCCTGTGTTTTAGTATTTGGCCCAGAGGTTTCCTAAATGGTTGCCTTGAAATCACTGTGGTCCAAATGTAATTCTTACACACTC
AAATTATCACTGTCTGTAGCACACTTGTGCACCTGTCTTACATTCTCTGTTGCTCCCCCCCACACTCTTGCTCAGTCTGTCACCTGTTCA
GTCTGCTTACTCACTCAATTGTTACCCTTTTGCTGTTGTCGTGTTTACAGTTTGCATTTTGAATGATTAGTTGGGATTACCAAACATTTT

>94_94_2_AARSD1-FBXL20_AARSD1_chr17_41108221_ENST00000427569_FBXL20_chr17_37499494_ENST00000394294_length(amino acids)=611AA_BP=219
MAFWCQRDSYAREFTTTVVSCCPAELQTEGSNGKKEVLSGFQVVLEDTVLFPEGGGQPDDRGTINDISVLRVTRRGEQADHFTQTPLDPG
SQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKTTSWELGRFRSAIELDTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEV
EQVSGRGLPDDHAGPIRVVNIEGVDSNMCCGTHVSNLSDLQMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGS
NWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDAEGCPLLEQLNISWCDQVTKD
GIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRL
RILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCP

--------------------------------------------------------------
>94_94_3_AARSD1-FBXL20_AARSD1_chr17_41108221_ENST00000427569_FBXL20_chr17_37499494_ENST00000577399_length(transcript)=1968nt_BP=699nt
TTCTCTGCGCGTGCGCCTCCTCACACGCCTGCAGGTATGGCGTTCTGGTGTCAGCGTGACAGTTATGCCCGAGAGTTCACCACCACCGTG
GTCTCCTGCTGTCCCGCGGAGCTGCAGACTGAAGGGAGCAACGGCAAGAAAGAAGTGCTGAGCGGTTTCCAAGTGGTGCTGGAAGACACA
GTGCTTTTCCCTGAGGGCGGGGGACAGCCTGATGACCGTGGTACAATCAATGACATCTCTGTGCTGAGAGTGACTCGCCGTGGGGAACAG
GCTGATCATTTCACCCAGACACCCCTGGATCCAGGAAGCCAGGTTCTGGTCCGGGTAGATTGGGAGCGGAGGTTTGACCACATGCAGCAG
CATTCAGGGCAGCATCTCATCACGGCAGTTGCTGACCATCTATTTAAGCTGAAGACAACATCATGGGAGTTAGGGAGATTTCGGAGTGCG
ATTGAGCTGGACACCCCCTCTATGACTGCAGAGCAAGTAGCTGCCATTGAGCAGAGCGTCAATGAAAAAATCAGAGATCGGCTGCCTGTG
AATGTCCGAGAACTGAGCCTGGATGATCCTGAGGTGGAGCAGGTGAGTGGCCGGGGTTTGCCTGATGATCATGCTGGGCCCATTCGGGTT
GTTAACATCGAGGGCGTTGATTCCAACATGTGCTGTGGGACCCATGTGAGCAATCTCAGTGACCTTCAGATGTTCTCAAATAGTGATGAA
GCTGTAATCAATAAAAAACTTCCCAAAGAACTCCTGTTACGGATATTTTCTTTTCTAGATGTTGTTACCCTGTGCCGCTGTGCTCAGGTC
TCCAGGGCCTGGAATGTTCTGGCTCTGGATGGCAGTAACTGGCAGCGAATTGACCTATTTGATTTCCAGAGGGATATTGAGGGCCGAGTA
GTGGAGAATATTTCAAAACGATGTGGGGGCTTTTTACGAAAGTTAAGTCTTCGTGGATGTCTTGGAGTGGGAGACAATGCATTAAGAACC
TTTGCACAAAACTGCAGGAACATTGAAGTACTGAATCTAAATGGGTGTACAAAGACAACAGACGCTACATGTACTAGCCTTAGCAAGTTC
TGTTCCAAACTCAGGCACCTTGACTTGGCTTCCTGTACATCAATAACAAACATGTCTCTAAAAGCTCTGAGTGAGGGATGTCCACTGTTG
GAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCAAGGCCTTATTC
TTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACTTGCAGACTTGC
TTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCTCCAACATCACA
GATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAGATGTGGGCTTT
ACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAATCCAACTTTCT
ATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGAATGGGGCCTGC
GCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCTGTCATAGCCTT
GAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTAAAGTCCACGCC

>94_94_3_AARSD1-FBXL20_AARSD1_chr17_41108221_ENST00000427569_FBXL20_chr17_37499494_ENST00000577399_length(amino acids)=643AA_BP=219
MAFWCQRDSYAREFTTTVVSCCPAELQTEGSNGKKEVLSGFQVVLEDTVLFPEGGGQPDDRGTINDISVLRVTRRGEQADHFTQTPLDPG
SQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKTTSWELGRFRSAIELDTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEV
EQVSGRGLPDDHAGPIRVVNIEGVDSNMCCGTHVSNLSDLQMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGS
NWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASC
TSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITIC
RGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLS
HCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVG

--------------------------------------------------------------
>94_94_4_AARSD1-FBXL20_AARSD1_chr17_41108221_ENST00000427569_FBXL20_chr17_37499494_ENST00000583610_length(transcript)=2142nt_BP=699nt
TTCTCTGCGCGTGCGCCTCCTCACACGCCTGCAGGTATGGCGTTCTGGTGTCAGCGTGACAGTTATGCCCGAGAGTTCACCACCACCGTG
GTCTCCTGCTGTCCCGCGGAGCTGCAGACTGAAGGGAGCAACGGCAAGAAAGAAGTGCTGAGCGGTTTCCAAGTGGTGCTGGAAGACACA
GTGCTTTTCCCTGAGGGCGGGGGACAGCCTGATGACCGTGGTACAATCAATGACATCTCTGTGCTGAGAGTGACTCGCCGTGGGGAACAG
GCTGATCATTTCACCCAGACACCCCTGGATCCAGGAAGCCAGGTTCTGGTCCGGGTAGATTGGGAGCGGAGGTTTGACCACATGCAGCAG
CATTCAGGGCAGCATCTCATCACGGCAGTTGCTGACCATCTATTTAAGCTGAAGACAACATCATGGGAGTTAGGGAGATTTCGGAGTGCG
ATTGAGCTGGACACCCCCTCTATGACTGCAGAGCAAGTAGCTGCCATTGAGCAGAGCGTCAATGAAAAAATCAGAGATCGGCTGCCTGTG
AATGTCCGAGAACTGAGCCTGGATGATCCTGAGGTGGAGCAGGTGAGTGGCCGGGGTTTGCCTGATGATCATGCTGGGCCCATTCGGGTT
GTTAACATCGAGGGCGTTGATTCCAACATGTGCTGTGGGACCCATGTGAGCAATCTCAGTGACCTTCAGATGTTCTCAAATAGTGATGAA
GCTGTAATCAATAAAAAACTTCCCAAAGAACTCCTGTTACGGATATTTTCTTTTCTAGATGTTGTTACCCTGTGCCGCTGTGCTCAGGTC
TCCAGGGCCTGGAATGTTCTGGCTCTGGATGGCAGTAACTGGCAGCGAATTGACCTATTTGATTTCCAGAGGGATATTGAGGGCCGAGTA
GTGGAGAATATTTCAAAACGATGTGGGGGCTTTTTACGAAAGTTAAGTCTTCGTGGATGTCTTGGAGTGGGAGACAATGCATTAAGAACC
TTTGCACAAAACTGCAGGAACATTGAAGTACTGAATCTAAATGGGTGTACAAAGACAACAGACGCTACATGTACTAGCCTTAGCAAGTTC
TGTTCCAAACTCAGGCACCTTGACTTGGCTTCCTGTACATCAATAACAAACATGTCTCTAAAAGCTCTGAGTGAGGGATGTCCACTGTTG
GAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCAAGGCCTTATTC
TTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACTTGCAGACTTGC
TTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCTCCAACATCACA
GATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAGATGTGGGCTTT
ACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAATCCAACTTTCT
ATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGAATGGGGCCTGC
GCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCTGTCATAGCCTT
GAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTAAAGTCCACGCC
TACTTCGCACCTGTCACTCCACCCCCATCAGTAGGGGGCAGCAGACAGCGCTTCTGCAGATGCTGCATCATCCTATGACAATGGAGAGAT
GGGGTCTCGCTATCTTGCCCAGCCTGGACTCAAACTCCTGGGCTCAAGCCTTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACAGG

>94_94_4_AARSD1-FBXL20_AARSD1_chr17_41108221_ENST00000427569_FBXL20_chr17_37499494_ENST00000583610_length(amino acids)=643AA_BP=219
MAFWCQRDSYAREFTTTVVSCCPAELQTEGSNGKKEVLSGFQVVLEDTVLFPEGGGQPDDRGTINDISVLRVTRRGEQADHFTQTPLDPG
SQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKTTSWELGRFRSAIELDTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEV
EQVSGRGLPDDHAGPIRVVNIEGVDSNMCCGTHVSNLSDLQMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGS
NWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASC
TSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITIC
RGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLS
HCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AARSD1-FBXL20

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AARSD1-FBXL20

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AARSD1-FBXL20

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source