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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIM24-BRAF (FusionGDB2 ID:94004)

Fusion Gene Summary for TRIM24-BRAF

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM24-BRAF
Fusion gene ID: 94004
HgeneTgene
Gene symbol

TRIM24

BRAF

Gene ID

8805

673

Gene nametripartite motif containing 24B-Raf proto-oncogene, serine/threonine kinase
SynonymsPTC6|RNF82|TF1A|TIF1|TIF1A|TIF1ALPHA|hTIF1B-RAF1|B-raf|BRAF1|NS7|RAFB1
Cytomap

7q33-q34

7q34

Type of geneprotein-codingprotein-coding
Descriptiontranscription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene
Modification date2020031320200329
UniProtAcc.

P15056

Ensembl transtripts involved in fusion geneENST00000497516, ENST00000343526, 
ENST00000415680, 		ENST00000288602, 
Fusion gene scores* DoF score10 X 9 X 7=63048 X 58 X 16=44544
# samples 1069
** MAII scorelog2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(69/44544*10)=-6.0124909441832
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM24 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIM24(138255748)-BRAF(140550012), # samples:3
BRAF(140624366)-TRIM24(138258252), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM24

GO:0016567

protein ubiquitination

19556538

HgeneTRIM24

GO:0071391

cellular response to estrogen stimulus

21164480

TgeneBRAF

GO:0000186

activation of MAPKK activity

29433126

TgeneBRAF

GO:0006468

protein phosphorylation

17563371

TgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

TgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

TgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

TgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

TgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278


check buttonFusion gene breakpoints across TRIM24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRAF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-AACL-01ATRIM24chr7

138239609

-BRAFchr7

140550012

-
ChimerDB4READTCGA-F5-6464-01ATRIM24chr7

138255748

-BRAFchr7

140550012

-
ChimerDB4READTCGA-F5-6464-01ATRIM24chr7

138255748

+BRAFchr7

140550012

-
ChimerDB4READTCGA-F5-6464TRIM24chr7

138255748

+BRAFchr7

140550012

-


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Fusion Gene ORF analysis for TRIM24-BRAF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497516ENST00000288602TRIM24chr7

138239609

-BRAFchr7

140550012

-
In-frameENST00000343526ENST00000288602TRIM24chr7

138239609

-BRAFchr7

140550012

-
In-frameENST00000343526ENST00000288602TRIM24chr7

138255748

+BRAFchr7

140550012

-
In-frameENST00000415680ENST00000288602TRIM24chr7

138239609

-BRAFchr7

140550012

-
In-frameENST00000415680ENST00000288602TRIM24chr7

138255748

+BRAFchr7

140550012

-
intron-3CDSENST00000497516ENST00000288602TRIM24chr7

138255748

+BRAFchr7

140550012

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343526TRIM24chr7138255748+ENST00000288602BRAFchr7140550012-437420939242551387
ENST00000415680TRIM24chr7138255748+ENST00000288602BRAFchr7140550012-4171189011440521312
ENST00000343526TRIM24chr7138239609-ENST00000288602BRAFchr7140550012-3859157814793740753
ENST00000415680TRIM24chr7138239609-ENST00000288602BRAFchr7140550012-3823154211437041196

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343526ENST00000288602TRIM24chr7138255748+BRAFchr7140550012-0.0007846620.99921536
ENST00000415680ENST00000288602TRIM24chr7138255748+BRAFchr7140550012-0.0007780930.9992219
ENST00000343526ENST00000288602TRIM24chr7138239609-BRAFchr7140550012-0.0009217240.9990783
ENST00000415680ENST00000288602TRIM24chr7138239609-BRAFchr7140550012-0.0004732420.99952674

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Fusion Genomic Features for TRIM24-BRAF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIM24-BRAF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:138255748/chr7:140550012)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BRAF

P15056

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919289_3594761017.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119289_3596261051.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119289_3595921017.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919344_3474761017.0Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-9199_154761017.0Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119344_3476261051.0Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+11199_156261051.0Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119344_3475921017.0Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+11199_155921017.0Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919158_2114761017.0Zinc fingerB box-type 1
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919218_2594761017.0Zinc fingerB box-type 2
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-91956_824761017.0Zinc fingerRING-type
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119158_2116261051.0Zinc fingerB box-type 1
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119218_2596261051.0Zinc fingerB box-type 2
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+111956_826261051.0Zinc fingerRING-type
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119158_2115921017.0Zinc fingerB box-type 1
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119218_2595921017.0Zinc fingerB box-type 2
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+111956_825921017.0Zinc fingerRING-type
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018122_12946767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018428_43246767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018122_12946767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018428_43246767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018155_22746767.0DomainRBD
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018457_71746767.0DomainProtein kinase
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018155_22746767.0DomainRBD
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018457_71746767.0DomainProtein kinase
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018463_47146767.0Nucleotide bindingATP
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018463_47146767.0Nucleotide bindingATP
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018234_28046767.0Zinc fingerPhorbol-ester/DAG-type
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018234_28046767.0Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119289_35901051.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119344_34701051.0Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-1199_1501051.0Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119932_98701051.0DomainBromo
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919932_9874761017.0DomainBromo
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119932_9876261051.0DomainBromo
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119932_9875921017.0DomainBromo
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119891_90701051.0MotifNuclear localization signal
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919891_9074761017.0MotifNuclear localization signal
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119891_9076261051.0MotifNuclear localization signal
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119891_9075921017.0MotifNuclear localization signal
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119754_77901051.0RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919754_7794761017.0RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119754_7796261051.0RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119754_7795921017.0RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119158_21101051.0Zinc fingerB box-type 1
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119218_25901051.0Zinc fingerB box-type 2
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-11956_8201051.0Zinc fingerRING-type
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119826_87301051.0Zinc fingerPHD-type
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919826_8734761017.0Zinc fingerPHD-type
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119826_8736261051.0Zinc fingerPHD-type
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119826_8735921017.0Zinc fingerPHD-type
TgeneBRAFchr7:138239609chr7:140550012ENST000002886020186_1146767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr7:138255748chr7:140550012ENST000002886020186_1146767.0Compositional biasNote=Poly-Gly


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Fusion Gene Sequence for TRIM24-BRAF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94004_94004_1_TRIM24-BRAF_TRIM24_chr7_138239609_ENST00000343526_BRAF_chr7_140550012_ENST00000288602_length(transcript)=3859nt_BP=1578nt
GACAGATACCCTCCTTCCGGCCGCGCCACTCGGGAGGCGGATCCCGTGGGCCTGAGGAGGCTTCCCCCGCCCGGTTTGCTTTCCCTCCCT
CGCTGGCGCTGCCGCGAGTCCACCGAGCGGCCTCTGAGGAGCAGCCGCAGGAGGAGGAGGAGGTCGTCGGGGGCGGCGGGCGGAGACCGC
GCTCTCGCTTCCCCGGCGGCGGCAAGGGCAGGACAATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGG
CCTCCGGGGGGCCCTCGGCGGCGCCGAGCGGGGAGAACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCC
GGCTCAACCTGTTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCC
AGCGCTGCCTGCCCGCGCCCCAGCGCTACCTCATGCTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCG
GCTCGCCGGTCAGCGGCTCGTCGCCGTTCGCCACCCAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACA
TCATAGATAACTTTTTTGTGAAGGACACTACTGAGGTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGTATGTACAAGCTGTGAGGACA
ACGCAGAAGCCAATGGGTTTTGTGTAGAGTGTGTTGAATGGCTCTGCAAGACGTGTATCAGAGCTCATCAGAGGGTAAAGTTCACAAAAG
ACCACACTGTCAGACAGAAAGAGGAAGTATCTCCAGAGGCAGTTGGTGTCACCAGCCAGCGACCAGTGTTTTGTCCTTTTCATAAAAAGG
AGCAGCTGAAGCTGTACTGTGAGACATGTGACAAACTGACATGTCGAGACTGTCAGTTGTTAGAACATAAAGAGCATAGATACCAATTTA
TAGAAGAAGCTTTTCAGAATCAGAAAGTGATCATAGATACACTAATCACCAAACTGATGGAAAAAACAAAATACATAAAATTCACAGGAA
ATCAGATCCAAAACAGAATTATTGAAGTAAATCAAAATCAAAAGCAGGTGGAACAGGATATTAAAGTTGCTATATTTACACTGATGGTAG
AAATAAATAAAAAAGGAAAAGCTCTACTGCATCAGTTAGAGAGCCTTGCAAAGGACCATCGCATGAAACTTATGCAACAACAACAGGAAG
TGGCTGGACTCTCTAAACAATTGGAGCATGTCATGCATTTTTCTAAATGGGCAGTTTCCAGTGGCAGCAGTACAGCATTACTTTATAGCA
AACGACTGATTACATACCGGTTACGGCACCTCCTTCGTGCAAGGTGTGATGCATCCCCAGTGACCAACAACACCATCCAATTTCACTGTG
ATCCTAGTTTCTGGGCTCAAAATATCATCAACTTAGGTAATGGCTCAGAGGCAACAGGTGCAACGGAGGCCAGCACCTGTGGGTTTACCA
AACCCTAGAATGCAGGGGCCCATCCAGCAACCTTCCATCTCTCATCAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACAT
ATAGAGGCCCTATTGGACAAATTTGGTGGGGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGAT
GCACTCCAACAAAGAGAACAACAGTTATTGGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTT
ACATCTTCTTCCTCTTCTAGCCTTTCAGTGCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAG
TCACCACAAAAACCTATCGTTAGAGTCTTCCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGT
CTAAAGAAAGCACTGATGATGAGAGGTCTAATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGG
GACACTGATATTTCCTGGCTTACTGGAGAAGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAA
ACGTTTTTCACCTTAGCATTTTGTGACTTTTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAG
CGTTGTAGTACAGAAGTTCCACTGATGTGTGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATA
CCACAGGAAGAGGCGTCCTTAGCAGAGACTGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATT
CTCACCAGTCCGTCTCCTTCAAAATCCATTCCAATTCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGA
GACCGATCCTCATCAGCTCCCAATGTGCATATAAACACAATAGAACCTGTCAATATTGATGACTTGATTAGAGACCAAGGATTTCGTGGT
GATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCA
GGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGG
GAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTG
GCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACAT
GTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCAT
CTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAG
TCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTG
AAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAA
AATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAAC
AACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAG
AGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCA
TTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCT
CCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAA

>94004_94004_1_TRIM24-BRAF_TRIM24_chr7_138239609_ENST00000343526_BRAF_chr7_140550012_ENST00000288602_length(amino acids)=753AA_BP=26
MAQRQQVQRRPAPVGLPNPRMQGPIQQPSISHQVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESL
GNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPE
CCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNY
DQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINT
IEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRI
GSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKL
IDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFG
IVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSL

--------------------------------------------------------------
>94004_94004_2_TRIM24-BRAF_TRIM24_chr7_138239609_ENST00000415680_BRAF_chr7_140550012_ENST00000288602_length(transcript)=3823nt_BP=1542nt
CCGCGAGTCCACCGAGCGGCCTCTGAGGAGCAGCCGCAGGAGGAGGAGGAGGTCGTCGGGGGCGGCGGGCGGAGACCGCGCTCTCGCTTC
CCCGGCGGCGGCAAGGGCAGGACAATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGGCCTCCGGGGGG
CCCTCGGCGGCGCCGAGCGGGGAGAACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCCGGCTCAACCTG
TTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCCAGCGCTGCCTG
CCCGCGCCCCAGCGCTACCTCATGCTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCGGCTCGCCGGTC
AGCGGCTCGTCGCCGTTCGCCACCCAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACATCATAGATAAC
TTTTTTGTGAAGGACACTACTGAGGTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGTATGTACAAGCTGTGAGGACAACGCAGAAGCC
AATGGGTTTTGTGTAGAGTGTGTTGAATGGCTCTGCAAGACGTGTATCAGAGCTCATCAGAGGGTAAAGTTCACAAAAGACCACACTGTC
AGACAGAAAGAGGAAGTATCTCCAGAGGCAGTTGGTGTCACCAGCCAGCGACCAGTGTTTTGTCCTTTTCATAAAAAGGAGCAGCTGAAG
CTGTACTGTGAGACATGTGACAAACTGACATGTCGAGACTGTCAGTTGTTAGAACATAAAGAGCATAGATACCAATTTATAGAAGAAGCT
TTTCAGAATCAGAAAGTGATCATAGATACACTAATCACCAAACTGATGGAAAAAACAAAATACATAAAATTCACAGGAAATCAGATCCAA
AACAGAATTATTGAAGTAAATCAAAATCAAAAGCAGGTGGAACAGGATATTAAAGTTGCTATATTTACACTGATGGTAGAAATAAATAAA
AAAGGAAAAGCTCTACTGCATCAGTTAGAGAGCCTTGCAAAGGACCATCGCATGAAACTTATGCAACAACAACAGGAAGTGGCTGGACTC
TCTAAACAATTGGAGCATGTCATGCATTTTTCTAAATGGGCAGTTTCCAGTGGCAGCAGTACAGCATTACTTTATAGCAAACGACTGATT
ACATACCGGTTACGGCACCTCCTTCGTGCAAGGTGTGATGCATCCCCAGTGACCAACAACACCATCCAATTTCACTGTGATCCTAGTTTC
TGGGCTCAAAATATCATCAACTTAGGTTCTTTAGTAATCGAGGATAAAGAGAGCCAGCCACAAATGCCTAAGCAGAATCCTGTCGTGGAA
CAGAATTCACAGCCACCAAGTGGTTTATCATCAAACCAGTTATCCAAGTTCCCAACACAGATCAGCCTAGCTCAATTACGGCTCCAGCAT
ATGCAGCAACAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGGGGAGCAT
AATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATTGGAATCT
CTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGTGCTACCT
TCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTTCCTGCCC
AACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCTAATCCCA
GAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGAAGAATTG
CATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTTTTGTCGA
AAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTGTGTTAAT
TATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGACTGCCCTA
ACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCATTCCAATT
CCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCATCAGCTCCCAATGTGCATATAAAC
ACAATAGAACCTGTCAATATTGATGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCC
CCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCA
GAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGA
ATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCT
CAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAG
CCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAA
CTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATA
TTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAG
TTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTT
GGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGA
TACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGAT
GAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCC
TTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCG
TTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAA

>94004_94004_2_TRIM24-BRAF_TRIM24_chr7_138239609_ENST00000415680_BRAF_chr7_140550012_ENST00000288602_length(amino acids)=1196AA_BP=476
MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLM
LPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVII
DTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSG
LSSNQLSKFPTQISLAQLRLQHMQQQVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFS
VSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRI
QDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLF
VSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNID
DLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT
VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQT
AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM
TGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQT

--------------------------------------------------------------
>94004_94004_3_TRIM24-BRAF_TRIM24_chr7_138255748_ENST00000343526_BRAF_chr7_140550012_ENST00000288602_length(transcript)=4374nt_BP=2093nt
GACAGATACCCTCCTTCCGGCCGCGCCACTCGGGAGGCGGATCCCGTGGGCCTGAGGAGGCTTCCCCCGCCCGGTTTGCTTTCCCTCCCT
CGCTGGCGCTGCCGCGAGTCCACCGAGCGGCCTCTGAGGAGCAGCCGCAGGAGGAGGAGGAGGTCGTCGGGGGCGGCGGGCGGAGACCGC
GCTCTCGCTTCCCCGGCGGCGGCAAGGGCAGGACAATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGG
CCTCCGGGGGGCCCTCGGCGGCGCCGAGCGGGGAGAACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCC
GGCTCAACCTGTTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCC
AGCGCTGCCTGCCCGCGCCCCAGCGCTACCTCATGCTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCG
GCTCGCCGGTCAGCGGCTCGTCGCCGTTCGCCACCCAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACA
TCATAGATAACTTTTTTGTGAAGGACACTACTGAGGTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGTATGTACAAGCTGTGAGGACA
ACGCAGAAGCCAATGGGTTTTGTGTAGAGTGTGTTGAATGGCTCTGCAAGACGTGTATCAGAGCTCATCAGAGGGTAAAGTTCACAAAAG
ACCACACTGTCAGACAGAAAGAGGAAGTATCTCCAGAGGCAGTTGGTGTCACCAGCCAGCGACCAGTGTTTTGTCCTTTTCATAAAAAGG
AGCAGCTGAAGCTGTACTGTGAGACATGTGACAAACTGACATGTCGAGACTGTCAGTTGTTAGAACATAAAGAGCATAGATACCAATTTA
TAGAAGAAGCTTTTCAGAATCAGAAAGTGATCATAGATACACTAATCACCAAACTGATGGAAAAAACAAAATACATAAAATTCACAGGAA
ATCAGATCCAAAACAGAATTATTGAAGTAAATCAAAATCAAAAGCAGGTGGAACAGGATATTAAAGTTGCTATATTTACACTGATGGTAG
AAATAAATAAAAAAGGAAAAGCTCTACTGCATCAGTTAGAGAGCCTTGCAAAGGACCATCGCATGAAACTTATGCAACAACAACAGGAAG
TGGCTGGACTCTCTAAACAATTGGAGCATGTCATGCATTTTTCTAAATGGGCAGTTTCCAGTGGCAGCAGTACAGCATTACTTTATAGCA
AACGACTGATTACATACCGGTTACGGCACCTCCTTCGTGCAAGGTGTGATGCATCCCCAGTGACCAACAACACCATCCAATTTCACTGTG
ATCCTAGTTTCTGGGCTCAAAATATCATCAACTTAGGTTCTTTAGTAATCGAGGATAAAGAGAGCCAGCCACAAATGCCTAAGCAGAATC
CTGTCGTGGAACAGAATTCACAGCCACCAAGTGGTTTATCATCAAACCAGTTATCCAAGTTCCCAACACAGATCAGCCTAGCTCAATTAC
GGCTCCAGCATATGCAGCAACAGGTAATGGCTCAGAGGCAACAGGTGCAACGGAGGCCAGCACCTGTGGGTTTACCAAACCCTAGAATGC
AGGGGCCCATCCAGCAACCTTCCATCTCTCATCAGCAACCGCCTCCACGTTTGATAAACTTTCAGAATCACAGCCCCAAACCCAATGGAC
CAGTTCTTCCTCCTCATCCTCAACAACTGAGATATCCACCAAACCAGAACATACCACGACAAGCAATAAAGCCAAACCCCCTACAGATGG
CTTTCTTGGCTCAACAAGCCATAAAACAGTGGCAGATCAGCAGTGGACAGGGAACCCCATCAACTACCAACAGCACATCCTCTACTCCTT
CCAGCCCCACGATTACTAGTGCAGCAGGATATGATGGAAAGGCTTTTGGTTCACCTATGATCGATTTGAGCTCACCAGTGGGAGGGTCTT
ATAATCTTCCCTCTCTTCCGGATGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTG
GTGGGGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGT
TATTGGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTT
CAGTGCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAG
TCTTCCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAG
GTCTAATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTG
GAGAAGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTG
ACTTTTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGA
TGTGTGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAG
AGACTGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAAT
CCATTCCAATTCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCATCAGCTCCCAATG
TGCATATAAACACAATAGAACCTGTCAATATTGATGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGT
CTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCAT
CTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAG
TGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAG
CACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCT
ATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTG
AGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGA
GTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATC
AGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATG
TATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGG
TGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAA
AGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCAT
CAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGG
GATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGC

>94004_94004_3_TRIM24-BRAF_TRIM24_chr7_138255748_ENST00000343526_BRAF_chr7_140550012_ENST00000288602_length(amino acids)=1387AA_BP=667
MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAAR
LNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHI
IDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKE
QLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVE
INKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD
PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQ
GPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPS
SPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQL
LESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRG
LIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLM
CVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNV
HINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITV
GQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFE
MIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDV
YAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSAS

--------------------------------------------------------------
>94004_94004_4_TRIM24-BRAF_TRIM24_chr7_138255748_ENST00000415680_BRAF_chr7_140550012_ENST00000288602_length(transcript)=4171nt_BP=1890nt
CCGCGAGTCCACCGAGCGGCCTCTGAGGAGCAGCCGCAGGAGGAGGAGGAGGTCGTCGGGGGCGGCGGGCGGAGACCGCGCTCTCGCTTC
CCCGGCGGCGGCAAGGGCAGGACAATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGGCCTCCGGGGGG
CCCTCGGCGGCGCCGAGCGGGGAGAACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCCGGCTCAACCTG
TTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCCAGCGCTGCCTG
CCCGCGCCCCAGCGCTACCTCATGCTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCGGCTCGCCGGTC
AGCGGCTCGTCGCCGTTCGCCACCCAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACATCATAGATAAC
TTTTTTGTGAAGGACACTACTGAGGTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGTATGTACAAGCTGTGAGGACAACGCAGAAGCC
AATGGGTTTTGTGTAGAGTGTGTTGAATGGCTCTGCAAGACGTGTATCAGAGCTCATCAGAGGGTAAAGTTCACAAAAGACCACACTGTC
AGACAGAAAGAGGAAGTATCTCCAGAGGCAGTTGGTGTCACCAGCCAGCGACCAGTGTTTTGTCCTTTTCATAAAAAGGAGCAGCTGAAG
CTGTACTGTGAGACATGTGACAAACTGACATGTCGAGACTGTCAGTTGTTAGAACATAAAGAGCATAGATACCAATTTATAGAAGAAGCT
TTTCAGAATCAGAAAGTGATCATAGATACACTAATCACCAAACTGATGGAAAAAACAAAATACATAAAATTCACAGGAAATCAGATCCAA
AACAGAATTATTGAAGTAAATCAAAATCAAAAGCAGGTGGAACAGGATATTAAAGTTGCTATATTTACACTGATGGTAGAAATAAATAAA
AAAGGAAAAGCTCTACTGCATCAGTTAGAGAGCCTTGCAAAGGACCATCGCATGAAACTTATGCAACAACAACAGGAAGTGGCTGGACTC
TCTAAACAATTGGAGCATGTCATGCATTTTTCTAAATGGGCAGTTTCCAGTGGCAGCAGTACAGCATTACTTTATAGCAAACGACTGATT
ACATACCGGTTACGGCACCTCCTTCGTGCAAGGTGTGATGCATCCCCAGTGACCAACAACACCATCCAATTTCACTGTGATCCTAGTTTC
TGGGCTCAAAATATCATCAACTTAGGTTCTTTAGTAATCGAGGATAAAGAGAGCCAGCCACAAATGCCTAAGCAGAATCCTGTCGTGGAA
CAGAATTCACAGCCACCAAGTGGTTTATCATCAAACCAGTTATCCAAGTTCCCAACACAGATCAGCCTAGCTCAATTACGGCTCCAGCAT
ATGCAGCAACAGCAACCGCCTCCACGTTTGATAAACTTTCAGAATCACAGCCCCAAACCCAATGGACCAGTTCTTCCTCCTCATCCTCAA
CAACTGAGATATCCACCAAACCAGAACATACCACGACAAGCAATAAAGCCAAACCCCCTACAGATGGCTTTCTTGGCTCAACAAGCCATA
AAACAGTGGCAGATCAGCAGTGGACAGGGAACCCCATCAACTACCAACAGCACATCCTCTACTCCTTCCAGCCCCACGATTACTAGTGCA
GCAGGATATGATGGAAAGGCTTTTGGTTCACCTATGATCGATTTGAGCTCACCAGTGGGAGGGTCTTATAATCTTCCCTCTCTTCCGGAT
GTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGGGGAGCATAATCCACCATCA
ATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATTGGAATCTCTGGGGAACGGA
ACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGTGCTACCTTCATCTCTTTCA
GTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTTCCTGCCCAACAAACAGAGG
ACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCTAATCCCAGAGTGCTGTGCT
GTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGAAGAATTGCATGTGGAAGTG
TTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTTTTGTCGAAAGCTGCTTTTC
CAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTGTGTTAATTATGACCAACTT
GATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGACTGCCCTAACATCTGGATCA
TCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCATTCCAATTCCACAGCCCTTC
CGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCATCAGCTCCCAATGTGCATATAAACACAATAGAACCT
GTCAATATTGATGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTA
CCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAAT
CGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGA
TCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAA
GCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCT
ATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATT
GCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAA
GACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCC
ATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTG
TATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCA
GATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTC
TTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCT
GGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCAC
TGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAAT

>94004_94004_4_TRIM24-BRAF_TRIM24_chr7_138255748_ENST00000415680_BRAF_chr7_140550012_ENST00000288602_length(amino acids)=1312AA_BP=592
MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLM
LPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVII
DTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSG
LSSNQLSKFPTQISLAQLRLQHMQQQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSG
QGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEE
YTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCG
VTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTC
GYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHR
NQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRR
DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEG
SSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEV
IRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI

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Fusion Gene PPI Analysis for TRIM24-BRAF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119834_84001051.0histone H3 that is not methylated at 'Lys-4' (H3K4me0)
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919834_840476.01017.0histone H3 that is not methylated at 'Lys-4' (H3K4me0)
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119834_840626.01051.0histone H3 that is not methylated at 'Lys-4' (H3K4me0)
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119834_840592.01017.0histone H3 that is not methylated at 'Lys-4' (H3K4me0)


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIM24-BRAF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIM24-BRAF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource