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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIM25-MSI2 (FusionGDB2 ID:94018)

Fusion Gene Summary for TRIM25-MSI2

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM25-MSI2
Fusion gene ID: 94018
HgeneTgene
Gene symbol

TRIM25

MSI2

Gene ID

7706

124540

Gene nametripartite motif containing 25musashi RNA binding protein 2
SynonymsEFP|RNF147|Z147|ZNF147MSI2H
Cytomap

17q22

17q22

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin/ISG15 ligase TRIM25RING finger protein 147RING-type E3 ubiquitin transferaseRING-type E3 ubiquitin transferase TRIM25estrogen-responsive finger proteintripartite motif protein TRIM25tripartite motif-containing protein 25ubiquitin/ISG15RNA-binding protein Musashi homolog 2musashi homolog 2musashi-2
Modification date2020031320200313
UniProtAcc.

Q96DH6

Ensembl transtripts involved in fusion geneENST00000316881, ENST00000537230, 
ENST00000573108, 		ENST00000579505, 
ENST00000284073, ENST00000322684, 
ENST00000416426, ENST00000442934, 
ENST00000579180, 
Fusion gene scores* DoF score9 X 9 X 4=32426 X 18 X 10=4680
# samples 1030
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/4680*10)=-3.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM25 [Title/Abstract] AND MSI2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIM25(54972704)-MSI2(55674229), # samples:2
TRIM25(54972704)-MSI2(55607037), # samples:2
MSI2(55339553)-TRIM25(54985924), # samples:1
Anticipated loss of major functional domain due to fusion event.TRIM25-MSI2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TRIM25-MSI2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM25

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

23077300

HgeneTRIM25

GO:0043627

response to estrogen

22452784

HgeneTRIM25

GO:0045087

innate immune response

18248090

HgeneTRIM25

GO:0046596

regulation of viral entry into host cell

18248090


check buttonFusion gene breakpoints across TRIM25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MSI2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0I9-01ATRIM25chr17

54972704

-MSI2chr17

55607037

+
ChimerDB4BRCATCGA-B6-A0I9-01ATRIM25chr17

54972704

-MSI2chr17

55674229

+


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Fusion Gene ORF analysis for TRIM25-MSI2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000316881ENST00000579505TRIM25chr17

54972704

-MSI2chr17

55607037

+
5CDS-3UTRENST00000316881ENST00000579505TRIM25chr17

54972704

-MSI2chr17

55674229

+
5CDS-3UTRENST00000537230ENST00000579505TRIM25chr17

54972704

-MSI2chr17

55607037

+
5CDS-3UTRENST00000537230ENST00000579505TRIM25chr17

54972704

-MSI2chr17

55674229

+
Frame-shiftENST00000316881ENST00000284073TRIM25chr17

54972704

-MSI2chr17

55607037

+
Frame-shiftENST00000316881ENST00000322684TRIM25chr17

54972704

-MSI2chr17

55607037

+
Frame-shiftENST00000316881ENST00000416426TRIM25chr17

54972704

-MSI2chr17

55607037

+
Frame-shiftENST00000316881ENST00000442934TRIM25chr17

54972704

-MSI2chr17

55607037

+
Frame-shiftENST00000316881ENST00000579180TRIM25chr17

54972704

-MSI2chr17

55607037

+
Frame-shiftENST00000537230ENST00000284073TRIM25chr17

54972704

-MSI2chr17

55607037

+
Frame-shiftENST00000537230ENST00000322684TRIM25chr17

54972704

-MSI2chr17

55607037

+
Frame-shiftENST00000537230ENST00000416426TRIM25chr17

54972704

-MSI2chr17

55607037

+
Frame-shiftENST00000537230ENST00000442934TRIM25chr17

54972704

-MSI2chr17

55607037

+
Frame-shiftENST00000537230ENST00000579180TRIM25chr17

54972704

-MSI2chr17

55607037

+
In-frameENST00000316881ENST00000284073TRIM25chr17

54972704

-MSI2chr17

55674229

+
In-frameENST00000316881ENST00000322684TRIM25chr17

54972704

-MSI2chr17

55674229

+
In-frameENST00000316881ENST00000416426TRIM25chr17

54972704

-MSI2chr17

55674229

+
In-frameENST00000316881ENST00000442934TRIM25chr17

54972704

-MSI2chr17

55674229

+
In-frameENST00000316881ENST00000579180TRIM25chr17

54972704

-MSI2chr17

55674229

+
In-frameENST00000537230ENST00000284073TRIM25chr17

54972704

-MSI2chr17

55674229

+
In-frameENST00000537230ENST00000322684TRIM25chr17

54972704

-MSI2chr17

55674229

+
In-frameENST00000537230ENST00000416426TRIM25chr17

54972704

-MSI2chr17

55674229

+
In-frameENST00000537230ENST00000442934TRIM25chr17

54972704

-MSI2chr17

55674229

+
In-frameENST00000537230ENST00000579180TRIM25chr17

54972704

-MSI2chr17

55674229

+
intron-3CDSENST00000573108ENST00000284073TRIM25chr17

54972704

-MSI2chr17

55607037

+
intron-3CDSENST00000573108ENST00000284073TRIM25chr17

54972704

-MSI2chr17

55674229

+
intron-3CDSENST00000573108ENST00000322684TRIM25chr17

54972704

-MSI2chr17

55607037

+
intron-3CDSENST00000573108ENST00000322684TRIM25chr17

54972704

-MSI2chr17

55674229

+
intron-3CDSENST00000573108ENST00000416426TRIM25chr17

54972704

-MSI2chr17

55607037

+
intron-3CDSENST00000573108ENST00000416426TRIM25chr17

54972704

-MSI2chr17

55674229

+
intron-3CDSENST00000573108ENST00000442934TRIM25chr17

54972704

-MSI2chr17

55607037

+
intron-3CDSENST00000573108ENST00000442934TRIM25chr17

54972704

-MSI2chr17

55674229

+
intron-3CDSENST00000573108ENST00000579180TRIM25chr17

54972704

-MSI2chr17

55607037

+
intron-3CDSENST00000573108ENST00000579180TRIM25chr17

54972704

-MSI2chr17

55674229

+
intron-3UTRENST00000573108ENST00000579505TRIM25chr17

54972704

-MSI2chr17

55607037

+
intron-3UTRENST00000573108ENST00000579505TRIM25chr17

54972704

-MSI2chr17

55674229

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000316881TRIM25chr1754972704-ENST00000416426MSI2chr1755674229+26041413501999649
ENST00000316881TRIM25chr1754972704-ENST00000284073MSI2chr1755674229+71141413501945631
ENST00000316881TRIM25chr1754972704-ENST00000322684MSI2chr1755674229+27961413501726558
ENST00000316881TRIM25chr1754972704-ENST00000442934MSI2chr1755674229+27261413501945631
ENST00000316881TRIM25chr1754972704-ENST00000579180MSI2chr1755674229+28011413501726558
ENST00000537230TRIM25chr1754972704-ENST00000416426MSI2chr1755674229+25931402391988649
ENST00000537230TRIM25chr1754972704-ENST00000284073MSI2chr1755674229+71031402391934631
ENST00000537230TRIM25chr1754972704-ENST00000322684MSI2chr1755674229+27851402391715558
ENST00000537230TRIM25chr1754972704-ENST00000442934MSI2chr1755674229+27151402391934631
ENST00000537230TRIM25chr1754972704-ENST00000579180MSI2chr1755674229+27901402391715558

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316881ENST00000416426TRIM25chr1754972704-MSI2chr1755674229+0.014885240.98511475
ENST00000316881ENST00000284073TRIM25chr1754972704-MSI2chr1755674229+0.0011658120.9988342
ENST00000316881ENST00000322684TRIM25chr1754972704-MSI2chr1755674229+0.0118760630.98812395
ENST00000316881ENST00000442934TRIM25chr1754972704-MSI2chr1755674229+0.0112821560.9887178
ENST00000316881ENST00000579180TRIM25chr1754972704-MSI2chr1755674229+0.0111106490.98888934
ENST00000537230ENST00000416426TRIM25chr1754972704-MSI2chr1755674229+0.0148371280.9851629
ENST00000537230ENST00000284073TRIM25chr1754972704-MSI2chr1755674229+0.0011504060.99884963
ENST00000537230ENST00000322684TRIM25chr1754972704-MSI2chr1755674229+0.0117895250.98821044
ENST00000537230ENST00000442934TRIM25chr1754972704-MSI2chr1755674229+0.011181680.98881835
ENST00000537230ENST00000579180TRIM25chr1754972704-MSI2chr1755674229+0.0110099470.98899007

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Fusion Genomic Features for TRIM25-MSI2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRIM25chr1754972703-MSI2chr1755674228+0.0002883440.9997116
TRIM25chr1754972703-MSI2chr1755607036+1.66E-070.9999999
TRIM25chr1754972703-MSI2chr1755674228+0.0002883440.9997116
TRIM25chr1754972703-MSI2chr1755607036+1.66E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TRIM25-MSI2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:54972704/chr17:55674229)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MSI2

Q96DH6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM25chr17:54972704chr17:55674229ENST00000316881-89217_307454631.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM25chr17:54972704chr17:55674229ENST00000537230-810217_307454684.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneTRIM25chr17:54972704chr17:55674229ENST00000316881-8913_54454631.0Zinc fingerRING-type
HgeneTRIM25chr17:54972704chr17:55674229ENST00000537230-81013_54454684.3333333333334Zinc fingerRING-type
TgeneMSI2chr17:54972704chr17:55674229ENST00000284073614253_2601511951.0Compositional biasNote=Poly-Ala
TgeneMSI2chr17:54972704chr17:55674229ENST00000322684510253_260147252.0Compositional biasNote=Poly-Ala
TgeneMSI2chr17:54972704chr17:55674229ENST0000057918027253_26047152.0Compositional biasNote=Poly-Ala
TgeneMSI2chr17:54972704chr17:55674229ENST0000057918027110_18747152.0DomainRRM 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM25chr17:54972704chr17:55674229ENST00000316881-89439_630454631.0DomainB30.2/SPRY
HgeneTRIM25chr17:54972704chr17:55674229ENST00000537230-810439_630454684.3333333333334DomainB30.2/SPRY
TgeneMSI2chr17:54972704chr17:55674229ENST00000284073614110_1871511951.0DomainRRM 2
TgeneMSI2chr17:54972704chr17:55674229ENST0000028407361421_1111511951.0DomainRRM 1
TgeneMSI2chr17:54972704chr17:55674229ENST00000322684510110_187147252.0DomainRRM 2
TgeneMSI2chr17:54972704chr17:55674229ENST0000032268451021_111147252.0DomainRRM 1
TgeneMSI2chr17:54972704chr17:55674229ENST000005791802721_11147152.0DomainRRM 1


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Fusion Gene Sequence for TRIM25-MSI2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94018_94018_1_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000316881_MSI2_chr17_55674229_ENST00000284073_length(transcript)=7114nt_BP=1413nt
CGGCCTCGGAGCGCGGGTGCAGCAGTTGTGTCCCGACCCCTGGGAGCGCCATGGCAGAGCTGTGCCCCCTGGCCGAGGAGCTGTCGTGCT
CCATCTGCCTGGAGCCCTTCAAGGAGCCGGTCACCACTCCGTGCGGCCACAACTTCTGCGGGTCGTGCCTGAATGAGACGTGGGCAGTCC
AGGGCTCGCCATACCTGTGCCCGCAGTGCCGCGCCGTCTACCAGGCGCGACCGCAGCTGCACAAGAACACGGTGCTGTGCAACGTGGTGG
AGCAGTTCCTGCAGGCCGACCTGGCCCGGGAGCCACCCGCCGACGTCTGGACGCCGCCCGCCCGCGCCTCTGCACCCAGCCCGAATGCCC
AGGTGGCCTGCGACCACTGCCTGAAGGAGGCCGCCGTGAAGACGTGCTTGGTGTGCATGGCCTCCTTCTGTCAGGAGCACCTGCAGCCGC
ACTTCGACAGCCCCGCCTTCCAGGACCACCCGCTGCAGCCGCCCGTTCGCGACCTGTTGCGCCGCAAATGTTCCCAGCACAATCGGCTGC
GGGAATTTTTCTGCCCCGAGCACAGCGAGTGCATCTGCCACATCTGCCTGGTGGAGCATAAGACCTGCTCTCCCGCGTCCCTGAGCCAGG
CCAGCGCCGACCTGGAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGA
GAAACAGGCAGCAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACG
CCTCAGAGACCACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGA
AGAAGAGTGAGATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAAC
TGCGAGGAATCTCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACC
TCAAAAACGAGCTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACAC
ACAAATCCACACGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTC
CCACGTTTGGAGCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAA
CATCTCTCAAGGCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTGGTTTGGCTTTGTCACTTTTGAGAATG
AAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCA
TGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCA
ACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGAC
CAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGAC
CTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCG
GCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGC
ATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCA
CTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAG
CTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCT
CCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCAT
AGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAG
ATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGT
GAAGTGCAGGGCGGGAGGTGGGCGTGAGCTTTCTATTTTGCGTTGTAGAAGAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCA
GTTCTTTTTGTGATGTCTCTTTGTTAATCTGAGTCTATCTATTTTCGGCAATAAGGTAAGGACGACAGTGTTTTGAGTGTCCTCCTTTTC
TATAAGTGCTTTTTTTCTGTTGAAAGAGGTGATATTATAAGGTTTTTTGAAATTGTGAATTCTAAAAAAGAAATGTTGTAAATACAATTC
CATTAACTACATAGAAACTATTAAGAAAGAGAGAATCAAAAATATTTTTGTGAGGGAGTCGGTCCCAGGCAGTTTGATGCTCTGTGGAAG
GAGGCGGGAAGGGAACGTTGGCCAAGTCAGTTACTGAGATGAAGATCGCCCAGCTGCCAGGACCACCCCAGGACAAGTTAGAGCACTGTT
TAGCTCCTTTGTCTGTGTGATAGACCTAAGAACTGTATTAGTGTTGTACCAGCCTATTAACCTCTTGTCTGTGCACAGCTTCAAATGTTA
CCGTCTAGTTAGATTTTTATTTAAAATATGAAAAACTGCTTTTCCCAAGATGTTTTTTAAAAACAAAGCTACAATTTTAATATTTAACAT
ATTTAAAGTTTCAAAGCACACCTGTTTGGCTTGGGTGGGGGTGGGGTGGGGGGGACATTCTTTTTCAGTCTTAATTTTTAAATATTTGAT
CATTTTCTATTGTCCAATCATTTCAGCACCTCCAAAGGTCCCTAGGACACTTTGCCTCTCTTCTCCCCCTGCCCCCCACCCTGCTCCCAC
ATCTGGGGGCCCATGGGCCAGGAGTGGATAAGCCTGCATTAATACAACCTTTCTCCATTCACTTTCTATTTACAAATTAGGAAAGCAACC
TTTTGGTTTATATATATTTTTTTTAATACCTCAGTGCTGCAAGTATCACCAGAGAGGCTATGGAAGAATTTTTTTTTAATTTATTGTAGA
TGTAAACAGAATTTTAAAAATAAAAAGTATAAACATCACTGCACTGTGACTGGTGGGAAAAACTGACAGTTTCCTCTTTGCACATGTTTA
ACATTTGGCTGTTATAATATATGGTCCTCGGTTGGGGAAAGATACTTATGATGAAGGATATTTTTTAATTTAACTTTTTTTTAAATATTG
GTAATAGGTCGGCAACAGCAACTATAGAAGTACAACTCAATAGATGGCATTAAAACATATTGTAGTGTGGATATATATTTTTTCTTTTTT
AAAATGTGATATTGACGTTTTATTAATATTTTTTAAATTGTTACGTTTATAAATTTGGTACTTAAGGCACAGCCAGTATGAGACACTGAA
TGCGACATTTATTATAAAGAGCTGCTGCACTCCTATTTTTATAAATTTTACTAACAAAGTAGACTAATGTAGACATTCACAGACATGGTA
GGGCAAAAGCATCTTCAAACTAAAGACTCCAAAATGCTAACTCAGAAAGAAAGAAAAAACCCGTTTTCAATTCTAATGAAACAGCAACAA
CATTTTTTTTAATTAAAAAAAAAATCATGTTCTTTGTTTTTCTAATAAAATGTTAGGTTGTTTGGTGAGGTTTTTTTGTTGTTTTTTTCC
TTTCTTTGTTTCTTTTCTTTTCCCCCAAACAACCAGATTAAATGCTGAGCGCTTTTAAAATATCAAAACTTGTTCAAGTCATAAAACAAC
AAAACATAAGTTTTATTTAAAAAAAAAAAAAGAAAGAAAAAATAGTAAATTCCCAGAAATTCAGTGTTTAGACGAGGGAATTTAATTCCT
ATTTTGTCCATGTTGGTGATGTACTGTACTTCCCTTCCTTTTCTCTGCATCCCCCATCACCTCATAGAAGACTCTTTGTTGATCATTGTA
TGTTAATAATGTATAAAATGGCTATCTTGTAAGCGTGCTGTCCTGGTACTAGTGTAGCGACTTTTTTTCTCCTCTTTCTTCTAGTACATA
TTGATAGGTATAACATAATTAAGGTTTAAAAAAAATTAGACATAGTTATTCAGATTTAGGACCAGTAAGGATAGAACTTTCTCTTATTTA
TGAAAAAAAATGCTAATAATTTTGGGGCAGTTTTTTCCTTTAATTATTTTTTTCAATTTCAAGTTTAATTTTATTTTAGCTGATCTGATG
TGGTTTCAACTAACCCAAGGTCTCACCATGTTAAAATGCCGGCGGACTCTACGGCGTTTTGTAGATCCCCCCCCCCCCACCCACTGTGAA
GGGGTGCCATACTACCTTAAATGCTAATGCTAGATATGCAAAACTGGATTTTTTTAATTTATTTTTTAAAAGAGGGAGGCATGGTATATT
AAAATGATTTTACTAAGAGAAAAAATATTTTTTTAAGAATGCTCAGAAGAAATTGATAATCTGTGTGAATATGTTTTAGATGTTTATATA
CCTTTTGAAGAGACCCAGTAGCCCATAGCACAAATCTTGTGGAAATCCGATATGTTTTAATGTGGCTACCTAGGTTTAAGGTTCACGTTA
GTCCCCCCATTCCATCTAGAAGTCCATTTTGAAAGATTTTTGTAAATTCTTTTAACACTGATGTTTCAGCCTCGTCTTTGTTTCAGTTAA
GCTCAATGGCGAACATGGGAACCACCTTTCGCCTTCCCTGGGGGAGAAACCCTCTTGGCTGATGGCTTTTCCCCGGAATTATCAAACAGC
CACCGGGTGACTTTCTGGCTTCCAGATCCATCTGCCTGAGACCCCCGAACTCCTCTCCTCCCAAGCAGAGGCGAGTGAGTGGCATTAGCT
CCCGGACCCATTCCCGGTCCTAGCTGGGCATGGGGCTGACGGAGATGACCAAGCCTTGGTCTGCTCTCTAGCAGCTTCCACAGACTTGGC
TCGTGGCCTTCCTTATATCCACTGGGAACAAACAGCCTCGCGCTCTATACCAAACAGCCTCGCGCTCTATCCCAGTCGCCCATTAGCTTG
ATTCAAACAAAGCCCCAGCAGGCCTTTGCGTTTTTATCCTTCATAACCTTCATCTTAATTTGAACTTGTAGCTTGGACTTTAAGGTAGCA
TGGCTCTATTGCTGTCAATTTACTGTTTCACTGCACAGCAATCACAGCCAGTGAATGTTACACACATCTTGCTAGACTAGTATAAAAATC
ATTGGGTAATTGTTGGTTCTAATGACCTGAAAGGTGTTCAGTTTTTGTTCTTGGTTTTGTTTTGTTTTTGATTTCTTGGGGGTGGGTTTT
GCTTGTTGTTCCTTTTCATTTGGGGGTTTTTGGGGAAAAAATTTATTTTTGGTTCCAAATAGAAAAACAAAACCTATTTTGATCTTTAGT
GCAAACGAGGGCTAGGGACTTAGCCTCCTCCACCACCTCCACACTGCTTCATTCTGCCATTCACTCACTGCAGCATATTCAAGAATAAAG
CAATATCGTTTACTACATTTTTTATTGAAGGTCAGCCATGCTTTCTGTATTATATTGCATATGAAATTGTTTACAAAAGAAACACTAACT
CATACTTCTCTTTATTGGTTGCAAGTGGCACGCAGGAACAGAGGGAGAGTGGGGGGCTGGTGGGGGAGGGGAGATTTTTTTTTTTTTTTC
TTGAATGTGCTTCGCAAGCCAGGCTATCTTCCAAGGAAGGCAGACAGTGGGAGAGCAGAGGGACTGACTGCAGGCAAGCACATTGAAGAA
AGACACTGGCGGGTTTCCCCACCCTCACCCCAAAGCAGAAAACTAGCAGACGTCAGCTCAGCCCCGTCCTGGGCACAGACACTACACAAG
GAGACGCTGGAAGTTAAGCAATACTTTAATACTGTAATATGTTTGTTTTCTTTTTCTTTCTTTTTTTTCTACCAAAAAAAAGTAAGTAAA
CTAAAACACAAAAACATATAAATAAAATCCATCCCTCTTGTCGGGGACCTGCAGGGGGGCAACCTTAATCCAAACACCTGGCTATCAAAT
AATCAGAATGTATTGTCTCAGACAGGATTTCAGTTCCGGGAGGCAGGGGCATGATGGGGGAGGGGGCCGGAGGCTGAGAGACAAAAGTTC
CAGAGCCTCCCTCGAAGGTTCTCTACTACTGTATTCTGTACATAATGTACCATCCCATGTGGAATCTGTGAGTGTCCTCTTAAGTAGCGT
GGGCTAGCCAATCTGCCGTTCATGGTGTATTGTAAACTCCGAATTCCATATGTAATAGGATGCAAGTCTAAGCGTTTCATGTGGACATAA
ATGTATCTAAATAAAACTTTCCCTAGCACTGTGGCTGACCTCACCCTTACTTTTATACTTTAGTATGAAACTGATGAGAACTTTGGTAGT
GAGTATTTTTTTTATATATATACATATATATGTACTATCTATATATATATCTCAAGCATCTTTCAGGTCTTTGTGTGTGGCTTTCTTAAA
GCCCTGTTGTAAAAAATTACTATGTGGATGGCAGTCTCTCACATCACAGATGTGGAAAGTATAATTTTATATTTGTATTTTCAAATAAAT
AAGTTTGTGAAAGGTTTCCATCCTCTACTGTGGTCCAGAAATCAATGTGTTTGTCTGACAAAAAAAAAAATAAAATAAAATAAACTGTTT

>94018_94018_1_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000316881_MSI2_chr17_55674229_ENST00000284073_length(amino acids)=631AA_BP=455
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVW
TPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRV
NSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
ELLEWFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY
GYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGY

--------------------------------------------------------------
>94018_94018_2_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000316881_MSI2_chr17_55674229_ENST00000322684_length(transcript)=2796nt_BP=1413nt
CGGCCTCGGAGCGCGGGTGCAGCAGTTGTGTCCCGACCCCTGGGAGCGCCATGGCAGAGCTGTGCCCCCTGGCCGAGGAGCTGTCGTGCT
CCATCTGCCTGGAGCCCTTCAAGGAGCCGGTCACCACTCCGTGCGGCCACAACTTCTGCGGGTCGTGCCTGAATGAGACGTGGGCAGTCC
AGGGCTCGCCATACCTGTGCCCGCAGTGCCGCGCCGTCTACCAGGCGCGACCGCAGCTGCACAAGAACACGGTGCTGTGCAACGTGGTGG
AGCAGTTCCTGCAGGCCGACCTGGCCCGGGAGCCACCCGCCGACGTCTGGACGCCGCCCGCCCGCGCCTCTGCACCCAGCCCGAATGCCC
AGGTGGCCTGCGACCACTGCCTGAAGGAGGCCGCCGTGAAGACGTGCTTGGTGTGCATGGCCTCCTTCTGTCAGGAGCACCTGCAGCCGC
ACTTCGACAGCCCCGCCTTCCAGGACCACCCGCTGCAGCCGCCCGTTCGCGACCTGTTGCGCCGCAAATGTTCCCAGCACAATCGGCTGC
GGGAATTTTTCTGCCCCGAGCACAGCGAGTGCATCTGCCACATCTGCCTGGTGGAGCATAAGACCTGCTCTCCCGCGTCCCTGAGCCAGG
CCAGCGCCGACCTGGAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGA
GAAACAGGCAGCAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACG
CCTCAGAGACCACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGA
AGAAGAGTGAGATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAAC
TGCGAGGAATCTCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACC
TCAAAAACGAGCTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACAC
ACAAATCCACACGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTC
CCACGTTTGGAGCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAA
CATCTCTCAAGGCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTGGTTTGGCTTTGTCACTTTTGAGAATG
AAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCA
TGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCA
ACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACA
TAATTTTTATCAACTAGCTCTTAAGAGAGGCATAGCAAAGTGGGGGTTGCTACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGC
TGCCCCCGCTCCAGTCAATGCTCACTGAAAGTCTGTCTTAGCTGCCTGTTTGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTC
ATGTCCTCATTGCTTCACTCAATTAAAAAAAAATTATTCTCCAGTCCCCTCCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTT
CCTCAGAATGTAACGGGGCCAGAGGGAAACTTCTCACAAACTTCGTAGAGCCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTT
TAAGTCATGACCAAACAGGCTTGTTGGGGACATATCATGGGGTGAGCTTTGAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTT
GGAGCACCCGTGTCTTACGATGGACAGTGATAAAGGTGAACACACAGAGACAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAG
AGGAGCTATATAAACACTATCTGACTATCTTTGTCTTTTGGGGCCAGTGGCTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGG
ACAGTGGAGTCATCCAGGTGCTGCCACATGACAGGCACGGTGGGCACCGATCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCC
TGTGCTGGCCTGGCCTTGCCTGCTGGCACCATTGGAGTAGGAGGGGGTGGAACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGT
TGGCACTCCTGCCCATCACCCTTAGAAGGATCTTTTCCCATGGCTTGACTTCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGA
ATAATGACGTACCACTCAGTTGGACCCTCAAGAGTCACTGCTTTGTCTGTGCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTG
ATGCATTTGATGTGAGTGAATCCATACATTTGAATGTCATTGTCCTTGAGACCCTACATGTGCAGTTTGGCTCATCTCATTAAAGATGCT

>94018_94018_2_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000316881_MSI2_chr17_55674229_ENST00000322684_length(amino acids)=558AA_BP=455
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVW
TPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRV
NSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
ELLEWFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY

--------------------------------------------------------------
>94018_94018_3_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000316881_MSI2_chr17_55674229_ENST00000416426_length(transcript)=2604nt_BP=1413nt
CGGCCTCGGAGCGCGGGTGCAGCAGTTGTGTCCCGACCCCTGGGAGCGCCATGGCAGAGCTGTGCCCCCTGGCCGAGGAGCTGTCGTGCT
CCATCTGCCTGGAGCCCTTCAAGGAGCCGGTCACCACTCCGTGCGGCCACAACTTCTGCGGGTCGTGCCTGAATGAGACGTGGGCAGTCC
AGGGCTCGCCATACCTGTGCCCGCAGTGCCGCGCCGTCTACCAGGCGCGACCGCAGCTGCACAAGAACACGGTGCTGTGCAACGTGGTGG
AGCAGTTCCTGCAGGCCGACCTGGCCCGGGAGCCACCCGCCGACGTCTGGACGCCGCCCGCCCGCGCCTCTGCACCCAGCCCGAATGCCC
AGGTGGCCTGCGACCACTGCCTGAAGGAGGCCGCCGTGAAGACGTGCTTGGTGTGCATGGCCTCCTTCTGTCAGGAGCACCTGCAGCCGC
ACTTCGACAGCCCCGCCTTCCAGGACCACCCGCTGCAGCCGCCCGTTCGCGACCTGTTGCGCCGCAAATGTTCCCAGCACAATCGGCTGC
GGGAATTTTTCTGCCCCGAGCACAGCGAGTGCATCTGCCACATCTGCCTGGTGGAGCATAAGACCTGCTCTCCCGCGTCCCTGAGCCAGG
CCAGCGCCGACCTGGAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGA
GAAACAGGCAGCAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACG
CCTCAGAGACCACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGA
AGAAGAGTGAGATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAAC
TGCGAGGAATCTCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACC
TCAAAAACGAGCTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACAC
ACAAATCCACACGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTC
CCACGTTTGGAGCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAA
CATCTCTCAAGGCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTGGTTTGGCTTTGTCACTTTTGAGAATG
AAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCA
TGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCA
ACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGAC
CAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGTCCTGAATAGCTACAGTGCTCAACCGAATTTTGGCGCGCCCGCTTCCCCGG
CAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACT
CCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCT
TTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTC
TGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATC
GAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTT
GTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGAT
TTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTA
AAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTC

>94018_94018_3_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000316881_MSI2_chr17_55674229_ENST00000416426_length(amino acids)=649AA_BP=455
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVW
TPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRV
NSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
ELLEWFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY
GYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSG

--------------------------------------------------------------
>94018_94018_4_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000316881_MSI2_chr17_55674229_ENST00000442934_length(transcript)=2726nt_BP=1413nt
CGGCCTCGGAGCGCGGGTGCAGCAGTTGTGTCCCGACCCCTGGGAGCGCCATGGCAGAGCTGTGCCCCCTGGCCGAGGAGCTGTCGTGCT
CCATCTGCCTGGAGCCCTTCAAGGAGCCGGTCACCACTCCGTGCGGCCACAACTTCTGCGGGTCGTGCCTGAATGAGACGTGGGCAGTCC
AGGGCTCGCCATACCTGTGCCCGCAGTGCCGCGCCGTCTACCAGGCGCGACCGCAGCTGCACAAGAACACGGTGCTGTGCAACGTGGTGG
AGCAGTTCCTGCAGGCCGACCTGGCCCGGGAGCCACCCGCCGACGTCTGGACGCCGCCCGCCCGCGCCTCTGCACCCAGCCCGAATGCCC
AGGTGGCCTGCGACCACTGCCTGAAGGAGGCCGCCGTGAAGACGTGCTTGGTGTGCATGGCCTCCTTCTGTCAGGAGCACCTGCAGCCGC
ACTTCGACAGCCCCGCCTTCCAGGACCACCCGCTGCAGCCGCCCGTTCGCGACCTGTTGCGCCGCAAATGTTCCCAGCACAATCGGCTGC
GGGAATTTTTCTGCCCCGAGCACAGCGAGTGCATCTGCCACATCTGCCTGGTGGAGCATAAGACCTGCTCTCCCGCGTCCCTGAGCCAGG
CCAGCGCCGACCTGGAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGA
GAAACAGGCAGCAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACG
CCTCAGAGACCACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGA
AGAAGAGTGAGATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAAC
TGCGAGGAATCTCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACC
TCAAAAACGAGCTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACAC
ACAAATCCACACGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTC
CCACGTTTGGAGCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAA
CATCTCTCAAGGCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTGGTTTGGCTTTGTCACTTTTGAGAATG
AAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCA
TGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCA
ACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGAC
CAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGAC
CTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCG
GCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGC
ATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCA
CTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAG
CTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCT
CCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCAT
AGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAG
ATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGT
GAAGTGCAGGGCGGGAGGTGGGCGTGAGCTTTCTATTTTGCGTTGTAGAAGAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCA
GTTCTTTTTGTGATGTCTCTTTGTTAATCTGAGTCTATCTATTTTCGGCAATAAGGTAAGGACGACAGTGTTTTGAGTGTCCTCCTTTTC

>94018_94018_4_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000316881_MSI2_chr17_55674229_ENST00000442934_length(amino acids)=631AA_BP=455
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVW
TPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRV
NSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
ELLEWFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY
GYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGY

--------------------------------------------------------------
>94018_94018_5_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000316881_MSI2_chr17_55674229_ENST00000579180_length(transcript)=2801nt_BP=1413nt
CGGCCTCGGAGCGCGGGTGCAGCAGTTGTGTCCCGACCCCTGGGAGCGCCATGGCAGAGCTGTGCCCCCTGGCCGAGGAGCTGTCGTGCT
CCATCTGCCTGGAGCCCTTCAAGGAGCCGGTCACCACTCCGTGCGGCCACAACTTCTGCGGGTCGTGCCTGAATGAGACGTGGGCAGTCC
AGGGCTCGCCATACCTGTGCCCGCAGTGCCGCGCCGTCTACCAGGCGCGACCGCAGCTGCACAAGAACACGGTGCTGTGCAACGTGGTGG
AGCAGTTCCTGCAGGCCGACCTGGCCCGGGAGCCACCCGCCGACGTCTGGACGCCGCCCGCCCGCGCCTCTGCACCCAGCCCGAATGCCC
AGGTGGCCTGCGACCACTGCCTGAAGGAGGCCGCCGTGAAGACGTGCTTGGTGTGCATGGCCTCCTTCTGTCAGGAGCACCTGCAGCCGC
ACTTCGACAGCCCCGCCTTCCAGGACCACCCGCTGCAGCCGCCCGTTCGCGACCTGTTGCGCCGCAAATGTTCCCAGCACAATCGGCTGC
GGGAATTTTTCTGCCCCGAGCACAGCGAGTGCATCTGCCACATCTGCCTGGTGGAGCATAAGACCTGCTCTCCCGCGTCCCTGAGCCAGG
CCAGCGCCGACCTGGAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGA
GAAACAGGCAGCAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACG
CCTCAGAGACCACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGA
AGAAGAGTGAGATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAAC
TGCGAGGAATCTCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACC
TCAAAAACGAGCTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACAC
ACAAATCCACACGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTC
CCACGTTTGGAGCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAA
CATCTCTCAAGGCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTGGTTTGGCTTTGTCACTTTTGAGAATG
AAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCA
TGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCA
ACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACA
TAATTTTTATCAACTAGCTCTTAAGAGAGGCATAGCAAAGTGGGGGTTGCTACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGC
TGCCCCCGCTCCAGTCAATGCTCACTGAAAGTCTGTCTTAGCTGCCTGTTTGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTC
ATGTCCTCATTGCTTCACTCAATTAAAAAAAAATTATTCTCCAGTCCCCTCCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTT
CCTCAGAATGTAACGGGGCCAGAGGGAAACTTCTCACAAACTTCGTAGAGCCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTT
TAAGTCATGACCAAACAGGCTTGTTGGGGACATATCATGGGGTGAGCTTTGAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTT
GGAGCACCCGTGTCTTACGATGGACAGTGATAAAGGTGAACACACAGAGACAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAG
AGGAGCTATATAAACACTATCTGACTATCTTTGTCTTTTGGGGCCAGTGGCTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGG
ACAGTGGAGTCATCCAGGTGCTGCCACATGACAGGCACGGTGGGCACCGATCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCC
TGTGCTGGCCTGGCCTTGCCTGCTGGCACCATTGGAGTAGGAGGGGGTGGAACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGT
TGGCACTCCTGCCCATCACCCTTAGAAGGATCTTTTCCCATGGCTTGACTTCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGA
ATAATGACGTACCACTCAGTTGGACCCTCAAGAGTCACTGCTTTGTCTGTGCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTG
ATGCATTTGATGTGAGTGAATCCATACATTTGAATGTCATTGTCCTTGAGACCCTACATGTGCAGTTTGGCTCATCTCATTAAAGATGCT

>94018_94018_5_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000316881_MSI2_chr17_55674229_ENST00000579180_length(amino acids)=558AA_BP=455
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVW
TPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRV
NSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
ELLEWFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY

--------------------------------------------------------------
>94018_94018_6_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000537230_MSI2_chr17_55674229_ENST00000284073_length(transcript)=7103nt_BP=1402nt
CGCGGGTGCAGCAGTTGTGTCCCGACCCCTGGGAGCGCCATGGCAGAGCTGTGCCCCCTGGCCGAGGAGCTGTCGTGCTCCATCTGCCTG
GAGCCCTTCAAGGAGCCGGTCACCACTCCGTGCGGCCACAACTTCTGCGGGTCGTGCCTGAATGAGACGTGGGCAGTCCAGGGCTCGCCA
TACCTGTGCCCGCAGTGCCGCGCCGTCTACCAGGCGCGACCGCAGCTGCACAAGAACACGGTGCTGTGCAACGTGGTGGAGCAGTTCCTG
CAGGCCGACCTGGCCCGGGAGCCACCCGCCGACGTCTGGACGCCGCCCGCCCGCGCCTCTGCACCCAGCCCGAATGCCCAGGTGGCCTGC
GACCACTGCCTGAAGGAGGCCGCCGTGAAGACGTGCTTGGTGTGCATGGCCTCCTTCTGTCAGGAGCACCTGCAGCCGCACTTCGACAGC
CCCGCCTTCCAGGACCACCCGCTGCAGCCGCCCGTTCGCGACCTGTTGCGCCGCAAATGTTCCCAGCACAATCGGCTGCGGGAATTTTTC
TGCCCCGAGCACAGCGAGTGCATCTGCCACATCTGCCTGGTGGAGCATAAGACCTGCTCTCCCGCGTCCCTGAGCCAGGCCAGCGCCGAC
CTGGAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGAGAAACAGGCAG
CAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACGCCTCAGAGACC
ACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGAAGAAGAGTGAG
ATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAACTGCGAGGAATC
TCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACCTCAAAAACGAG
CTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACACACAAATCCACA
CGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTCCCACGTTTGGA
GCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAACATCTCTCAAG
GCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTG
GAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCT
GGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCG
ACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCA
GCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGAT
CTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATA
GCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATG
TCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCC
AACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGT
GTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATC
TCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGT
TATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATG
ACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGG
CGGGAGGTGGGCGTGAGCTTTCTATTTTGCGTTGTAGAAGAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGT
GATGTCTCTTTGTTAATCTGAGTCTATCTATTTTCGGCAATAAGGTAAGGACGACAGTGTTTTGAGTGTCCTCCTTTTCTATAAGTGCTT
TTTTTCTGTTGAAAGAGGTGATATTATAAGGTTTTTTGAAATTGTGAATTCTAAAAAAGAAATGTTGTAAATACAATTCCATTAACTACA
TAGAAACTATTAAGAAAGAGAGAATCAAAAATATTTTTGTGAGGGAGTCGGTCCCAGGCAGTTTGATGCTCTGTGGAAGGAGGCGGGAAG
GGAACGTTGGCCAAGTCAGTTACTGAGATGAAGATCGCCCAGCTGCCAGGACCACCCCAGGACAAGTTAGAGCACTGTTTAGCTCCTTTG
TCTGTGTGATAGACCTAAGAACTGTATTAGTGTTGTACCAGCCTATTAACCTCTTGTCTGTGCACAGCTTCAAATGTTACCGTCTAGTTA
GATTTTTATTTAAAATATGAAAAACTGCTTTTCCCAAGATGTTTTTTAAAAACAAAGCTACAATTTTAATATTTAACATATTTAAAGTTT
CAAAGCACACCTGTTTGGCTTGGGTGGGGGTGGGGTGGGGGGGACATTCTTTTTCAGTCTTAATTTTTAAATATTTGATCATTTTCTATT
GTCCAATCATTTCAGCACCTCCAAAGGTCCCTAGGACACTTTGCCTCTCTTCTCCCCCTGCCCCCCACCCTGCTCCCACATCTGGGGGCC
CATGGGCCAGGAGTGGATAAGCCTGCATTAATACAACCTTTCTCCATTCACTTTCTATTTACAAATTAGGAAAGCAACCTTTTGGTTTAT
ATATATTTTTTTTAATACCTCAGTGCTGCAAGTATCACCAGAGAGGCTATGGAAGAATTTTTTTTTAATTTATTGTAGATGTAAACAGAA
TTTTAAAAATAAAAAGTATAAACATCACTGCACTGTGACTGGTGGGAAAAACTGACAGTTTCCTCTTTGCACATGTTTAACATTTGGCTG
TTATAATATATGGTCCTCGGTTGGGGAAAGATACTTATGATGAAGGATATTTTTTAATTTAACTTTTTTTTAAATATTGGTAATAGGTCG
GCAACAGCAACTATAGAAGTACAACTCAATAGATGGCATTAAAACATATTGTAGTGTGGATATATATTTTTTCTTTTTTAAAATGTGATA
TTGACGTTTTATTAATATTTTTTAAATTGTTACGTTTATAAATTTGGTACTTAAGGCACAGCCAGTATGAGACACTGAATGCGACATTTA
TTATAAAGAGCTGCTGCACTCCTATTTTTATAAATTTTACTAACAAAGTAGACTAATGTAGACATTCACAGACATGGTAGGGCAAAAGCA
TCTTCAAACTAAAGACTCCAAAATGCTAACTCAGAAAGAAAGAAAAAACCCGTTTTCAATTCTAATGAAACAGCAACAACATTTTTTTTA
ATTAAAAAAAAAATCATGTTCTTTGTTTTTCTAATAAAATGTTAGGTTGTTTGGTGAGGTTTTTTTGTTGTTTTTTTCCTTTCTTTGTTT
CTTTTCTTTTCCCCCAAACAACCAGATTAAATGCTGAGCGCTTTTAAAATATCAAAACTTGTTCAAGTCATAAAACAACAAAACATAAGT
TTTATTTAAAAAAAAAAAAAGAAAGAAAAAATAGTAAATTCCCAGAAATTCAGTGTTTAGACGAGGGAATTTAATTCCTATTTTGTCCAT
GTTGGTGATGTACTGTACTTCCCTTCCTTTTCTCTGCATCCCCCATCACCTCATAGAAGACTCTTTGTTGATCATTGTATGTTAATAATG
TATAAAATGGCTATCTTGTAAGCGTGCTGTCCTGGTACTAGTGTAGCGACTTTTTTTCTCCTCTTTCTTCTAGTACATATTGATAGGTAT
AACATAATTAAGGTTTAAAAAAAATTAGACATAGTTATTCAGATTTAGGACCAGTAAGGATAGAACTTTCTCTTATTTATGAAAAAAAAT
GCTAATAATTTTGGGGCAGTTTTTTCCTTTAATTATTTTTTTCAATTTCAAGTTTAATTTTATTTTAGCTGATCTGATGTGGTTTCAACT
AACCCAAGGTCTCACCATGTTAAAATGCCGGCGGACTCTACGGCGTTTTGTAGATCCCCCCCCCCCCACCCACTGTGAAGGGGTGCCATA
CTACCTTAAATGCTAATGCTAGATATGCAAAACTGGATTTTTTTAATTTATTTTTTAAAAGAGGGAGGCATGGTATATTAAAATGATTTT
ACTAAGAGAAAAAATATTTTTTTAAGAATGCTCAGAAGAAATTGATAATCTGTGTGAATATGTTTTAGATGTTTATATACCTTTTGAAGA
GACCCAGTAGCCCATAGCACAAATCTTGTGGAAATCCGATATGTTTTAATGTGGCTACCTAGGTTTAAGGTTCACGTTAGTCCCCCCATT
CCATCTAGAAGTCCATTTTGAAAGATTTTTGTAAATTCTTTTAACACTGATGTTTCAGCCTCGTCTTTGTTTCAGTTAAGCTCAATGGCG
AACATGGGAACCACCTTTCGCCTTCCCTGGGGGAGAAACCCTCTTGGCTGATGGCTTTTCCCCGGAATTATCAAACAGCCACCGGGTGAC
TTTCTGGCTTCCAGATCCATCTGCCTGAGACCCCCGAACTCCTCTCCTCCCAAGCAGAGGCGAGTGAGTGGCATTAGCTCCCGGACCCAT
TCCCGGTCCTAGCTGGGCATGGGGCTGACGGAGATGACCAAGCCTTGGTCTGCTCTCTAGCAGCTTCCACAGACTTGGCTCGTGGCCTTC
CTTATATCCACTGGGAACAAACAGCCTCGCGCTCTATACCAAACAGCCTCGCGCTCTATCCCAGTCGCCCATTAGCTTGATTCAAACAAA
GCCCCAGCAGGCCTTTGCGTTTTTATCCTTCATAACCTTCATCTTAATTTGAACTTGTAGCTTGGACTTTAAGGTAGCATGGCTCTATTG
CTGTCAATTTACTGTTTCACTGCACAGCAATCACAGCCAGTGAATGTTACACACATCTTGCTAGACTAGTATAAAAATCATTGGGTAATT
GTTGGTTCTAATGACCTGAAAGGTGTTCAGTTTTTGTTCTTGGTTTTGTTTTGTTTTTGATTTCTTGGGGGTGGGTTTTGCTTGTTGTTC
CTTTTCATTTGGGGGTTTTTGGGGAAAAAATTTATTTTTGGTTCCAAATAGAAAAACAAAACCTATTTTGATCTTTAGTGCAAACGAGGG
CTAGGGACTTAGCCTCCTCCACCACCTCCACACTGCTTCATTCTGCCATTCACTCACTGCAGCATATTCAAGAATAAAGCAATATCGTTT
ACTACATTTTTTATTGAAGGTCAGCCATGCTTTCTGTATTATATTGCATATGAAATTGTTTACAAAAGAAACACTAACTCATACTTCTCT
TTATTGGTTGCAAGTGGCACGCAGGAACAGAGGGAGAGTGGGGGGCTGGTGGGGGAGGGGAGATTTTTTTTTTTTTTTCTTGAATGTGCT
TCGCAAGCCAGGCTATCTTCCAAGGAAGGCAGACAGTGGGAGAGCAGAGGGACTGACTGCAGGCAAGCACATTGAAGAAAGACACTGGCG
GGTTTCCCCACCCTCACCCCAAAGCAGAAAACTAGCAGACGTCAGCTCAGCCCCGTCCTGGGCACAGACACTACACAAGGAGACGCTGGA
AGTTAAGCAATACTTTAATACTGTAATATGTTTGTTTTCTTTTTCTTTCTTTTTTTTCTACCAAAAAAAAGTAAGTAAACTAAAACACAA
AAACATATAAATAAAATCCATCCCTCTTGTCGGGGACCTGCAGGGGGGCAACCTTAATCCAAACACCTGGCTATCAAATAATCAGAATGT
ATTGTCTCAGACAGGATTTCAGTTCCGGGAGGCAGGGGCATGATGGGGGAGGGGGCCGGAGGCTGAGAGACAAAAGTTCCAGAGCCTCCC
TCGAAGGTTCTCTACTACTGTATTCTGTACATAATGTACCATCCCATGTGGAATCTGTGAGTGTCCTCTTAAGTAGCGTGGGCTAGCCAA
TCTGCCGTTCATGGTGTATTGTAAACTCCGAATTCCATATGTAATAGGATGCAAGTCTAAGCGTTTCATGTGGACATAAATGTATCTAAA
TAAAACTTTCCCTAGCACTGTGGCTGACCTCACCCTTACTTTTATACTTTAGTATGAAACTGATGAGAACTTTGGTAGTGAGTATTTTTT
TTATATATATACATATATATGTACTATCTATATATATATCTCAAGCATCTTTCAGGTCTTTGTGTGTGGCTTTCTTAAAGCCCTGTTGTA
AAAAATTACTATGTGGATGGCAGTCTCTCACATCACAGATGTGGAAAGTATAATTTTATATTTGTATTTTCAAATAAATAAGTTTGTGAA

>94018_94018_6_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000537230_MSI2_chr17_55674229_ENST00000284073_length(amino acids)=631AA_BP=455
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVW
TPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRV
NSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
ELLEWFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY
GYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGY

--------------------------------------------------------------
>94018_94018_7_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000537230_MSI2_chr17_55674229_ENST00000322684_length(transcript)=2785nt_BP=1402nt
CGCGGGTGCAGCAGTTGTGTCCCGACCCCTGGGAGCGCCATGGCAGAGCTGTGCCCCCTGGCCGAGGAGCTGTCGTGCTCCATCTGCCTG
GAGCCCTTCAAGGAGCCGGTCACCACTCCGTGCGGCCACAACTTCTGCGGGTCGTGCCTGAATGAGACGTGGGCAGTCCAGGGCTCGCCA
TACCTGTGCCCGCAGTGCCGCGCCGTCTACCAGGCGCGACCGCAGCTGCACAAGAACACGGTGCTGTGCAACGTGGTGGAGCAGTTCCTG
CAGGCCGACCTGGCCCGGGAGCCACCCGCCGACGTCTGGACGCCGCCCGCCCGCGCCTCTGCACCCAGCCCGAATGCCCAGGTGGCCTGC
GACCACTGCCTGAAGGAGGCCGCCGTGAAGACGTGCTTGGTGTGCATGGCCTCCTTCTGTCAGGAGCACCTGCAGCCGCACTTCGACAGC
CCCGCCTTCCAGGACCACCCGCTGCAGCCGCCCGTTCGCGACCTGTTGCGCCGCAAATGTTCCCAGCACAATCGGCTGCGGGAATTTTTC
TGCCCCGAGCACAGCGAGTGCATCTGCCACATCTGCCTGGTGGAGCATAAGACCTGCTCTCCCGCGTCCCTGAGCCAGGCCAGCGCCGAC
CTGGAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGAGAAACAGGCAG
CAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACGCCTCAGAGACC
ACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGAAGAAGAGTGAG
ATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAACTGCGAGGAATC
TCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACCTCAAAAACGAG
CTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACACACAAATCCACA
CGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTCCCACGTTTGGA
GCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAACATCTCTCAAG
GCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTG
GAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCT
GGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCG
ACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATC
AACTAGCTCTTAAGAGAGGCATAGCAAAGTGGGGGTTGCTACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTC
CAGTCAATGCTCACTGAAAGTCTGTCTTAGCTGCCTGTTTGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATT
GCTTCACTCAATTAAAAAAAAATTATTCTCCAGTCCCCTCCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGT
AACGGGGCCAGAGGGAAACTTCTCACAAACTTCGTAGAGCCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGAC
CAAACAGGCTTGTTGGGGACATATCATGGGGTGAGCTTTGAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGT
GTCTTACGATGGACAGTGATAAAGGTGAACACACAGAGACAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATAT
AAACACTATCTGACTATCTTTGTCTTTTGGGGCCAGTGGCTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTC
ATCCAGGTGCTGCCACATGACAGGCACGGTGGGCACCGATCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCT
GGCCTTGCCTGCTGGCACCATTGGAGTAGGAGGGGGTGGAACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTG
CCCATCACCCTTAGAAGGATCTTTTCCCATGGCTTGACTTCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTA
CCACTCAGTTGGACCCTCAAGAGTCACTGCTTTGTCTGTGCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGAT

>94018_94018_7_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000537230_MSI2_chr17_55674229_ENST00000322684_length(amino acids)=558AA_BP=455
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVW
TPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRV
NSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
ELLEWFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY

--------------------------------------------------------------
>94018_94018_8_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000537230_MSI2_chr17_55674229_ENST00000416426_length(transcript)=2593nt_BP=1402nt
CGCGGGTGCAGCAGTTGTGTCCCGACCCCTGGGAGCGCCATGGCAGAGCTGTGCCCCCTGGCCGAGGAGCTGTCGTGCTCCATCTGCCTG
GAGCCCTTCAAGGAGCCGGTCACCACTCCGTGCGGCCACAACTTCTGCGGGTCGTGCCTGAATGAGACGTGGGCAGTCCAGGGCTCGCCA
TACCTGTGCCCGCAGTGCCGCGCCGTCTACCAGGCGCGACCGCAGCTGCACAAGAACACGGTGCTGTGCAACGTGGTGGAGCAGTTCCTG
CAGGCCGACCTGGCCCGGGAGCCACCCGCCGACGTCTGGACGCCGCCCGCCCGCGCCTCTGCACCCAGCCCGAATGCCCAGGTGGCCTGC
GACCACTGCCTGAAGGAGGCCGCCGTGAAGACGTGCTTGGTGTGCATGGCCTCCTTCTGTCAGGAGCACCTGCAGCCGCACTTCGACAGC
CCCGCCTTCCAGGACCACCCGCTGCAGCCGCCCGTTCGCGACCTGTTGCGCCGCAAATGTTCCCAGCACAATCGGCTGCGGGAATTTTTC
TGCCCCGAGCACAGCGAGTGCATCTGCCACATCTGCCTGGTGGAGCATAAGACCTGCTCTCCCGCGTCCCTGAGCCAGGCCAGCGCCGAC
CTGGAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGAGAAACAGGCAG
CAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACGCCTCAGAGACC
ACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGAAGAAGAGTGAG
ATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAACTGCGAGGAATC
TCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACCTCAAAAACGAG
CTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACACACAAATCCACA
CGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTCCCACGTTTGGA
GCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAACATCTCTCAAG
GCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTG
GAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCT
GGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCG
ACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCA
GCGGCGGTGGCGGCAGCAAGAGGATCAGTCCTGAATAGCTACAGTGCTCAACCGAATTTTGGCGCGCCCGCTTCCCCGGCAGGCTCCAAC
CCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGG
AATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGA
TACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCT
TTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACT
ACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTG
TTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGT
CCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTT
TTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTAT

>94018_94018_8_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000537230_MSI2_chr17_55674229_ENST00000416426_length(amino acids)=649AA_BP=455
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVW
TPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRV
NSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
ELLEWFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY
GYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSG

--------------------------------------------------------------
>94018_94018_9_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000537230_MSI2_chr17_55674229_ENST00000442934_length(transcript)=2715nt_BP=1402nt
CGCGGGTGCAGCAGTTGTGTCCCGACCCCTGGGAGCGCCATGGCAGAGCTGTGCCCCCTGGCCGAGGAGCTGTCGTGCTCCATCTGCCTG
GAGCCCTTCAAGGAGCCGGTCACCACTCCGTGCGGCCACAACTTCTGCGGGTCGTGCCTGAATGAGACGTGGGCAGTCCAGGGCTCGCCA
TACCTGTGCCCGCAGTGCCGCGCCGTCTACCAGGCGCGACCGCAGCTGCACAAGAACACGGTGCTGTGCAACGTGGTGGAGCAGTTCCTG
CAGGCCGACCTGGCCCGGGAGCCACCCGCCGACGTCTGGACGCCGCCCGCCCGCGCCTCTGCACCCAGCCCGAATGCCCAGGTGGCCTGC
GACCACTGCCTGAAGGAGGCCGCCGTGAAGACGTGCTTGGTGTGCATGGCCTCCTTCTGTCAGGAGCACCTGCAGCCGCACTTCGACAGC
CCCGCCTTCCAGGACCACCCGCTGCAGCCGCCCGTTCGCGACCTGTTGCGCCGCAAATGTTCCCAGCACAATCGGCTGCGGGAATTTTTC
TGCCCCGAGCACAGCGAGTGCATCTGCCACATCTGCCTGGTGGAGCATAAGACCTGCTCTCCCGCGTCCCTGAGCCAGGCCAGCGCCGAC
CTGGAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGAGAAACAGGCAG
CAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACGCCTCAGAGACC
ACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGAAGAAGAGTGAG
ATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAACTGCGAGGAATC
TCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACCTCAAAAACGAG
CTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACACACAAATCCACA
CGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTCCCACGTTTGGA
GCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAACATCTCTCAAG
GCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTG
GAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCT
GGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCG
ACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCA
GCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGAT
CTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATA
GCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATG
TCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCC
AACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGT
GTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATC
TCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGT
TATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATG
ACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGG
CGGGAGGTGGGCGTGAGCTTTCTATTTTGCGTTGTAGAAGAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGT
GATGTCTCTTTGTTAATCTGAGTCTATCTATTTTCGGCAATAAGGTAAGGACGACAGTGTTTTGAGTGTCCTCCTTTTCTATAAGTGCTT

>94018_94018_9_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000537230_MSI2_chr17_55674229_ENST00000442934_length(amino acids)=631AA_BP=455
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVW
TPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRV
NSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
ELLEWFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY
GYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGY

--------------------------------------------------------------
>94018_94018_10_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000537230_MSI2_chr17_55674229_ENST00000579180_length(transcript)=2790nt_BP=1402nt
CGCGGGTGCAGCAGTTGTGTCCCGACCCCTGGGAGCGCCATGGCAGAGCTGTGCCCCCTGGCCGAGGAGCTGTCGTGCTCCATCTGCCTG
GAGCCCTTCAAGGAGCCGGTCACCACTCCGTGCGGCCACAACTTCTGCGGGTCGTGCCTGAATGAGACGTGGGCAGTCCAGGGCTCGCCA
TACCTGTGCCCGCAGTGCCGCGCCGTCTACCAGGCGCGACCGCAGCTGCACAAGAACACGGTGCTGTGCAACGTGGTGGAGCAGTTCCTG
CAGGCCGACCTGGCCCGGGAGCCACCCGCCGACGTCTGGACGCCGCCCGCCCGCGCCTCTGCACCCAGCCCGAATGCCCAGGTGGCCTGC
GACCACTGCCTGAAGGAGGCCGCCGTGAAGACGTGCTTGGTGTGCATGGCCTCCTTCTGTCAGGAGCACCTGCAGCCGCACTTCGACAGC
CCCGCCTTCCAGGACCACCCGCTGCAGCCGCCCGTTCGCGACCTGTTGCGCCGCAAATGTTCCCAGCACAATCGGCTGCGGGAATTTTTC
TGCCCCGAGCACAGCGAGTGCATCTGCCACATCTGCCTGGTGGAGCATAAGACCTGCTCTCCCGCGTCCCTGAGCCAGGCCAGCGCCGAC
CTGGAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGAGAAACAGGCAG
CAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACGCCTCAGAGACC
ACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGAAGAAGAGTGAG
ATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAACTGCGAGGAATC
TCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACCTCAAAAACGAG
CTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACACACAAATCCACA
CGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTCCCACGTTTGGA
GCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAACATCTCTCAAG
GCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTG
GAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCT
GGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCG
ACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATC
AACTAGCTCTTAAGAGAGGCATAGCAAAGTGGGGGTTGCTACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTC
CAGTCAATGCTCACTGAAAGTCTGTCTTAGCTGCCTGTTTGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATT
GCTTCACTCAATTAAAAAAAAATTATTCTCCAGTCCCCTCCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGT
AACGGGGCCAGAGGGAAACTTCTCACAAACTTCGTAGAGCCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGAC
CAAACAGGCTTGTTGGGGACATATCATGGGGTGAGCTTTGAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGT
GTCTTACGATGGACAGTGATAAAGGTGAACACACAGAGACAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATAT
AAACACTATCTGACTATCTTTGTCTTTTGGGGCCAGTGGCTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTC
ATCCAGGTGCTGCCACATGACAGGCACGGTGGGCACCGATCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCT
GGCCTTGCCTGCTGGCACCATTGGAGTAGGAGGGGGTGGAACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTG
CCCATCACCCTTAGAAGGATCTTTTCCCATGGCTTGACTTCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTA
CCACTCAGTTGGACCCTCAAGAGTCACTGCTTTGTCTGTGCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGAT
GTGAGTGAATCCATACATTTGAATGTCATTGTCCTTGAGACCCTACATGTGCAGTTTGGCTCATCTCATTAAAGATGCTTGATGTAATAA

>94018_94018_10_TRIM25-MSI2_TRIM25_chr17_54972704_ENST00000537230_MSI2_chr17_55674229_ENST00000579180_length(amino acids)=558AA_BP=455
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVW
TPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRV
NSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
ELLEWFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRIM25-MSI2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneTRIM25chr17:54972704chr17:55674229ENST00000316881-89180_450454.3333333333333631.0influenza A virus NS1
HgeneTRIM25chr17:54972704chr17:55674229ENST00000537230-810180_450454.3333333333333684.3333333333334influenza A virus NS1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIM25-MSI2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIM25-MSI2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource