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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIM2-ARFIP1 (FusionGDB2 ID:94048)

Fusion Gene Summary for TRIM2-ARFIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM2-ARFIP1
Fusion gene ID: 94048
HgeneTgene
Gene symbol

TRIM2

ARFIP1

Gene ID

23321

27236

Gene nametripartite motif containing 2ADP ribosylation factor interacting protein 1
SynonymsCMT2R|RNF86HSU52521
Cytomap

4q31.3

4q31.3

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 2E3 ubiquitin-protein ligase TRIM2RING finger protein 86RING-type E3 ubiquitin transferase TRIM2tripartite motif protein TRIM2arfaptin-1
Modification date2020031520200313
UniProtAcc.

P53367

Ensembl transtripts involved in fusion geneENST00000494872, ENST00000338700, 
ENST00000437508, 		ENST00000353617, 
ENST00000356064, ENST00000405727, 
ENST00000429148, ENST00000451320, 
ENST00000511289, 
Fusion gene scores* DoF score18 X 16 X 9=259210 X 10 X 11=1100
# samples 2419
** MAII scorelog2(24/2592*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1100*10)=-2.53343220008107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM2 [Title/Abstract] AND ARFIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIM2(154125712)-ARFIP1(153831216), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARFIP1

GO:0006886

intracellular protein transport

12606037

TgeneARFIP1

GO:0050708

regulation of protein secretion

12606037


check buttonFusion gene breakpoints across TRIM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARFIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0X1-01ATRIM2chr4

154073764

+ARFIP1chr4

153750777

+
ChimerDB4BRCATCGA-B6-A0X1-01ATRIM2chr4

154125712

-ARFIP1chr4

153750777

+
ChimerDB4BRCATCGA-B6-A0X1-01ATRIM2chr4

154125712

+ARFIP1chr4

153750777

+
ChimerDB4OVTCGA-13-1506-01ATRIM2chr4

154125712

-ARFIP1chr4

153831216

+
ChimerDB4OVTCGA-13-1506-01ATRIM2chr4

154125712

+ARFIP1chr4

153831216

+
ChimerDB4OVTCGA-13-1506TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
ChimerDB4SKCMTCGA-FS-A1Z4-06ATRIM2chr4

154073764

+ARFIP1chr4

153784758

+
ChimerDB4SKCMTCGA-FS-A1Z4-06ATRIM2chr4

154191671

-ARFIP1chr4

153784758

+
ChimerDB4UCECTCGA-D1-A2G7-01ATRIM2chr4

154073764

+ARFIP1chr4

153831216

+


Top

Fusion Gene ORF analysis for TRIM2-ARFIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000494872ENST00000353617TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
3UTR-3CDSENST00000494872ENST00000353617TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
3UTR-3CDSENST00000494872ENST00000356064TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
3UTR-3CDSENST00000494872ENST00000356064TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
3UTR-3CDSENST00000494872ENST00000405727TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
3UTR-3CDSENST00000494872ENST00000405727TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
3UTR-3CDSENST00000494872ENST00000429148TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
3UTR-3CDSENST00000494872ENST00000429148TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
3UTR-3CDSENST00000494872ENST00000451320TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
3UTR-3CDSENST00000494872ENST00000451320TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
3UTR-3CDSENST00000494872ENST00000451320TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
3UTR-3UTRENST00000494872ENST00000511289TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
3UTR-5UTRENST00000494872ENST00000353617TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
3UTR-5UTRENST00000494872ENST00000356064TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
3UTR-5UTRENST00000494872ENST00000405727TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
3UTR-5UTRENST00000494872ENST00000429148TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
3UTR-5UTRENST00000494872ENST00000451320TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
3UTR-intronENST00000494872ENST00000353617TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
3UTR-intronENST00000494872ENST00000356064TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
3UTR-intronENST00000494872ENST00000405727TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
3UTR-intronENST00000494872ENST00000429148TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
3UTR-intronENST00000494872ENST00000511289TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
3UTR-intronENST00000494872ENST00000511289TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
3UTR-intronENST00000494872ENST00000511289TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
5CDS-3UTRENST00000338700ENST00000511289TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
5CDS-3UTRENST00000437508ENST00000511289TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
5CDS-5UTRENST00000338700ENST00000353617TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
5CDS-5UTRENST00000338700ENST00000356064TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
5CDS-5UTRENST00000338700ENST00000405727TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
5CDS-5UTRENST00000338700ENST00000429148TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
5CDS-5UTRENST00000338700ENST00000451320TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
5CDS-intronENST00000338700ENST00000353617TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
5CDS-intronENST00000338700ENST00000356064TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
5CDS-intronENST00000338700ENST00000405727TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
5CDS-intronENST00000338700ENST00000429148TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
5CDS-intronENST00000338700ENST00000511289TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
5CDS-intronENST00000338700ENST00000511289TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
5CDS-intronENST00000338700ENST00000511289TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
5CDS-intronENST00000437508ENST00000353617TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
5CDS-intronENST00000437508ENST00000356064TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
5CDS-intronENST00000437508ENST00000405727TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
5CDS-intronENST00000437508ENST00000429148TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
Frame-shiftENST00000338700ENST00000353617TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
Frame-shiftENST00000338700ENST00000353617TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
Frame-shiftENST00000338700ENST00000356064TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
Frame-shiftENST00000338700ENST00000356064TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
Frame-shiftENST00000338700ENST00000405727TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
Frame-shiftENST00000338700ENST00000405727TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
Frame-shiftENST00000338700ENST00000451320TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
Frame-shiftENST00000338700ENST00000451320TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
Frame-shiftENST00000338700ENST00000451320TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
Frame-shiftENST00000437508ENST00000451320TRIM2chr4

154191671

-ARFIP1chr4

153784758

+
In-frameENST00000338700ENST00000429148TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
In-frameENST00000338700ENST00000429148TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
intron-3CDSENST00000338700ENST00000353617TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000338700ENST00000356064TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000338700ENST00000405727TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000338700ENST00000429148TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000338700ENST00000451320TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-3CDSENST00000338700ENST00000451320TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000437508ENST00000353617TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
intron-3CDSENST00000437508ENST00000353617TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
intron-3CDSENST00000437508ENST00000353617TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000437508ENST00000356064TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
intron-3CDSENST00000437508ENST00000356064TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
intron-3CDSENST00000437508ENST00000356064TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000437508ENST00000405727TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
intron-3CDSENST00000437508ENST00000405727TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
intron-3CDSENST00000437508ENST00000405727TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000437508ENST00000429148TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
intron-3CDSENST00000437508ENST00000429148TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
intron-3CDSENST00000437508ENST00000429148TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000437508ENST00000451320TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
intron-3CDSENST00000437508ENST00000451320TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
intron-3CDSENST00000437508ENST00000451320TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-3CDSENST00000437508ENST00000451320TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000494872ENST00000353617TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000494872ENST00000356064TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000494872ENST00000405727TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000494872ENST00000429148TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3CDSENST00000494872ENST00000451320TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-3CDSENST00000494872ENST00000451320TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-3UTRENST00000338700ENST00000511289TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-3UTRENST00000437508ENST00000511289TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-3UTRENST00000494872ENST00000511289TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-5UTRENST00000338700ENST00000353617TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000338700ENST00000356064TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000338700ENST00000405727TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000338700ENST00000429148TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000338700ENST00000451320TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000437508ENST00000353617TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000437508ENST00000353617TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
intron-5UTRENST00000437508ENST00000356064TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000437508ENST00000356064TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
intron-5UTRENST00000437508ENST00000405727TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000437508ENST00000405727TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
intron-5UTRENST00000437508ENST00000429148TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000437508ENST00000429148TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
intron-5UTRENST00000437508ENST00000451320TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000437508ENST00000451320TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
intron-5UTRENST00000494872ENST00000353617TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000494872ENST00000356064TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000494872ENST00000405727TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000494872ENST00000429148TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-5UTRENST00000494872ENST00000451320TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-intronENST00000338700ENST00000353617TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000338700ENST00000356064TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000338700ENST00000405727TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000338700ENST00000429148TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000338700ENST00000511289TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-intronENST00000338700ENST00000511289TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-intronENST00000437508ENST00000353617TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000437508ENST00000356064TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000437508ENST00000405727TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000437508ENST00000429148TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000437508ENST00000511289TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-intronENST00000437508ENST00000511289TRIM2chr4

154125712

+ARFIP1chr4

153750777

+
intron-intronENST00000437508ENST00000511289TRIM2chr4

154125712

+ARFIP1chr4

153831216

+
intron-intronENST00000437508ENST00000511289TRIM2chr4

154125712

+ARFIP1chr4

153831215

+
intron-intronENST00000437508ENST00000511289TRIM2chr4

154073764

+ARFIP1chr4

153831216

+
intron-intronENST00000494872ENST00000353617TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000494872ENST00000356064TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000494872ENST00000405727TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000494872ENST00000429148TRIM2chr4

154073764

+ARFIP1chr4

153784758

+
intron-intronENST00000494872ENST00000511289TRIM2chr4

154073764

+ARFIP1chr4

153750777

+
intron-intronENST00000494872ENST00000511289TRIM2chr4

154073764

+ARFIP1chr4

153831216

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338700TRIM2chr4154125712+ENST00000429148ARFIP1chr4153831216+110695525081
ENST00000338700TRIM2chr4154125712+ENST00000429148ARFIP1chr4153831215+110695525081

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338700ENST00000429148TRIM2chr4154125712+ARFIP1chr4153831216+0.82318470.17681529
ENST00000338700ENST00000429148TRIM2chr4154125712+ARFIP1chr4153831215+0.82318470.17681529

Top

Fusion Genomic Features for TRIM2-ARFIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRIM2chr4154125712+ARFIP1chr4153831215+0.0020289290.9979711
TRIM2chr4154125712+ARFIP1chr4153831215+0.0020289290.9979711
TRIM2chr4154125712+ARFIP1chr4153750776+4.86E-060.9999951
TRIM2chr4154125712+ARFIP1chr4153831215+0.0020289290.9979711
TRIM2chr4154125712+ARFIP1chr4153831215+0.0020289290.9979711
TRIM2chr4154125712+ARFIP1chr4153750776+4.86E-060.9999951

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TRIM2-ARFIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:154125712/chr4:153831216)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARFIP1

P53367

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:9038142, PubMed:22981988). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM2chr4:154125712chr4:153831215ENST00000338700+112320_42110772.0RepeatNote=Filamin
HgeneTRIM2chr4:154125712chr4:153831215ENST00000338700+112473_51610772.0RepeatNote=NHL 1
HgeneTRIM2chr4:154125712chr4:153831215ENST00000338700+112520_56310772.0RepeatNote=NHL 2
HgeneTRIM2chr4:154125712chr4:153831215ENST00000338700+112564_60510772.0RepeatNote=NHL 3
HgeneTRIM2chr4:154125712chr4:153831215ENST00000338700+112609_65210772.0RepeatNote=NHL 4
HgeneTRIM2chr4:154125712chr4:153831215ENST00000338700+112656_69910772.0RepeatNote=NHL 5
HgeneTRIM2chr4:154125712chr4:153831215ENST00000338700+112700_74310772.0RepeatNote=NHL 6
HgeneTRIM2chr4:154125712chr4:153831215ENST00000437508+112320_4210745.0RepeatNote=Filamin
HgeneTRIM2chr4:154125712chr4:153831215ENST00000437508+112473_5160745.0RepeatNote=NHL 1
HgeneTRIM2chr4:154125712chr4:153831215ENST00000437508+112520_5630745.0RepeatNote=NHL 2
HgeneTRIM2chr4:154125712chr4:153831215ENST00000437508+112564_6050745.0RepeatNote=NHL 3
HgeneTRIM2chr4:154125712chr4:153831215ENST00000437508+112609_6520745.0RepeatNote=NHL 4
HgeneTRIM2chr4:154125712chr4:153831215ENST00000437508+112656_6990745.0RepeatNote=NHL 5
HgeneTRIM2chr4:154125712chr4:153831215ENST00000437508+112700_7430745.0RepeatNote=NHL 6
HgeneTRIM2chr4:154125712chr4:153831216ENST00000338700+112320_42110772.0RepeatNote=Filamin
HgeneTRIM2chr4:154125712chr4:153831216ENST00000338700+112473_51610772.0RepeatNote=NHL 1
HgeneTRIM2chr4:154125712chr4:153831216ENST00000338700+112520_56310772.0RepeatNote=NHL 2
HgeneTRIM2chr4:154125712chr4:153831216ENST00000338700+112564_60510772.0RepeatNote=NHL 3
HgeneTRIM2chr4:154125712chr4:153831216ENST00000338700+112609_65210772.0RepeatNote=NHL 4
HgeneTRIM2chr4:154125712chr4:153831216ENST00000338700+112656_69910772.0RepeatNote=NHL 5
HgeneTRIM2chr4:154125712chr4:153831216ENST00000338700+112700_74310772.0RepeatNote=NHL 6
HgeneTRIM2chr4:154125712chr4:153831216ENST00000437508+112320_4210745.0RepeatNote=Filamin
HgeneTRIM2chr4:154125712chr4:153831216ENST00000437508+112473_5160745.0RepeatNote=NHL 1
HgeneTRIM2chr4:154125712chr4:153831216ENST00000437508+112520_5630745.0RepeatNote=NHL 2
HgeneTRIM2chr4:154125712chr4:153831216ENST00000437508+112564_6050745.0RepeatNote=NHL 3
HgeneTRIM2chr4:154125712chr4:153831216ENST00000437508+112609_6520745.0RepeatNote=NHL 4
HgeneTRIM2chr4:154125712chr4:153831216ENST00000437508+112656_6990745.0RepeatNote=NHL 5
HgeneTRIM2chr4:154125712chr4:153831216ENST00000437508+112700_7430745.0RepeatNote=NHL 6
HgeneTRIM2chr4:154125712chr4:153831215ENST00000338700+112113_15410772.0Zinc fingerB box-type
HgeneTRIM2chr4:154125712chr4:153831215ENST00000338700+11223_6410772.0Zinc fingerRING-type
HgeneTRIM2chr4:154125712chr4:153831215ENST00000437508+112113_1540745.0Zinc fingerB box-type
HgeneTRIM2chr4:154125712chr4:153831215ENST00000437508+11223_640745.0Zinc fingerRING-type
HgeneTRIM2chr4:154125712chr4:153831216ENST00000338700+112113_15410772.0Zinc fingerB box-type
HgeneTRIM2chr4:154125712chr4:153831216ENST00000338700+11223_6410772.0Zinc fingerRING-type
HgeneTRIM2chr4:154125712chr4:153831216ENST00000437508+112113_1540745.0Zinc fingerB box-type
HgeneTRIM2chr4:154125712chr4:153831216ENST00000437508+11223_640745.0Zinc fingerRING-type
TgeneARFIP1chr4:154125712chr4:153831215ENST0000035361779153_353322374.0DomainAH
TgeneARFIP1chr4:154125712chr4:153831215ENST0000035606468153_353290342.0DomainAH
TgeneARFIP1chr4:154125712chr4:153831215ENST0000040572768153_353290342.0DomainAH
TgeneARFIP1chr4:154125712chr4:153831215ENST0000045132079153_353322374.0DomainAH
TgeneARFIP1chr4:154125712chr4:153831216ENST0000035361779153_353322374.0DomainAH
TgeneARFIP1chr4:154125712chr4:153831216ENST0000035606468153_353290342.0DomainAH
TgeneARFIP1chr4:154125712chr4:153831216ENST0000040572768153_353290342.0DomainAH
TgeneARFIP1chr4:154125712chr4:153831216ENST0000045132079153_353322374.0DomainAH


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Fusion Gene Sequence for TRIM2-ARFIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94048_94048_1_TRIM2-ARFIP1_TRIM2_chr4_154125712_ENST00000338700_ARFIP1_chr4_153831215_ENST00000429148_length(transcript)=1106nt_BP=95nt
CCCAGTTGTCTGCGGGCTGCGGGGAGCTAAGTCCCCAGATTGGAGGAGGCTGGCTCTGGTCTTCGATGCACAGGAGTGGCCGTTATGGAA
CGCAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGA
CACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAA
AAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGA
TTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATA
ATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAG
ATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTG
TATCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCA
GAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTT
TTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGC
TTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTT
TTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATT

>94048_94048_1_TRIM2-ARFIP1_TRIM2_chr4_154125712_ENST00000338700_ARFIP1_chr4_153831215_ENST00000429148_length(amino acids)=81AA_BP=29

--------------------------------------------------------------
>94048_94048_2_TRIM2-ARFIP1_TRIM2_chr4_154125712_ENST00000338700_ARFIP1_chr4_153831216_ENST00000429148_length(transcript)=1106nt_BP=95nt
CCCAGTTGTCTGCGGGCTGCGGGGAGCTAAGTCCCCAGATTGGAGGAGGCTGGCTCTGGTCTTCGATGCACAGGAGTGGCCGTTATGGAA
CGCAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGA
CACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAA
AAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGA
TTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATA
ATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAG
ATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTG
TATCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCA
GAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTT
TTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGC
TTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTT
TTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATT

>94048_94048_2_TRIM2-ARFIP1_TRIM2_chr4_154125712_ENST00000338700_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=81AA_BP=29

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Fusion Gene PPI Analysis for TRIM2-ARFIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIM2-ARFIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIM2-ARFIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource