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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIM37-MSI2 (FusionGDB2 ID:94099)

Fusion Gene Summary for TRIM37-MSI2

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM37-MSI2
Fusion gene ID: 94099
HgeneTgene
Gene symbol

TRIM37

MSI2

Gene ID

4591

124540

Gene nametripartite motif containing 37musashi RNA binding protein 2
SynonymsMUL|POB1|TEF3MSI2H
Cytomap

17q22

17q22

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism proteinRNA-binding protein Musashi homolog 2musashi homolog 2musashi-2
Modification date2020031320200313
UniProtAcc.

Q96DH6

Ensembl transtripts involved in fusion geneENST00000262294, ENST00000376149, 
ENST00000393065, ENST00000393066, 
ENST00000584889, 		ENST00000579505, 
ENST00000284073, ENST00000322684, 
ENST00000416426, ENST00000442934, 
ENST00000579180, 
Fusion gene scores* DoF score9 X 9 X 6=48626 X 18 X 10=4680
# samples 1130
** MAII scorelog2(11/486*10)=-2.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/4680*10)=-3.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM37 [Title/Abstract] AND MSI2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIM37(57148184)-MSI2(55478740), # samples:3
Anticipated loss of major functional domain due to fusion event.TRIM37-MSI2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TRIM37-MSI2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TRIM37-MSI2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM37

GO:0000122

negative regulation of transcription by RNA polymerase II

25470042

HgeneTRIM37

GO:0032088

negative regulation of NF-kappaB transcription factor activity

11279055

HgeneTRIM37

GO:0035518

histone H2A monoubiquitination

25470042

HgeneTRIM37

GO:0036353

histone H2A-K119 monoubiquitination

25470042

HgeneTRIM37

GO:0051091

positive regulation of DNA-binding transcription factor activity

23077300

HgeneTRIM37

GO:0051092

positive regulation of NF-kappaB transcription factor activity

23077300

HgeneTRIM37

GO:0051865

protein autoubiquitination

15885686

HgeneTRIM37

GO:0070842

aggresome assembly

15885686


check buttonFusion gene breakpoints across TRIM37 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MSI2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-CC-5258-01ATRIM37chr17

57148184

-MSI2chr17

55478740

+


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Fusion Gene ORF analysis for TRIM37-MSI2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262294ENST00000579505TRIM37chr17

57148184

-MSI2chr17

55478740

+
5CDS-intronENST00000376149ENST00000579505TRIM37chr17

57148184

-MSI2chr17

55478740

+
5CDS-intronENST00000393065ENST00000579505TRIM37chr17

57148184

-MSI2chr17

55478740

+
5CDS-intronENST00000393066ENST00000579505TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000262294ENST00000284073TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000262294ENST00000322684TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000262294ENST00000416426TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000262294ENST00000442934TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000262294ENST00000579180TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000393065ENST00000284073TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000393065ENST00000322684TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000393065ENST00000416426TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000393065ENST00000442934TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000393065ENST00000579180TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000393066ENST00000284073TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000393066ENST00000322684TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000393066ENST00000416426TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000393066ENST00000442934TRIM37chr17

57148184

-MSI2chr17

55478740

+
Frame-shiftENST00000393066ENST00000579180TRIM37chr17

57148184

-MSI2chr17

55478740

+
In-frameENST00000376149ENST00000284073TRIM37chr17

57148184

-MSI2chr17

55478740

+
In-frameENST00000376149ENST00000322684TRIM37chr17

57148184

-MSI2chr17

55478740

+
In-frameENST00000376149ENST00000416426TRIM37chr17

57148184

-MSI2chr17

55478740

+
In-frameENST00000376149ENST00000442934TRIM37chr17

57148184

-MSI2chr17

55478740

+
In-frameENST00000376149ENST00000579180TRIM37chr17

57148184

-MSI2chr17

55478740

+
intron-3CDSENST00000584889ENST00000284073TRIM37chr17

57148184

-MSI2chr17

55478740

+
intron-3CDSENST00000584889ENST00000322684TRIM37chr17

57148184

-MSI2chr17

55478740

+
intron-3CDSENST00000584889ENST00000416426TRIM37chr17

57148184

-MSI2chr17

55478740

+
intron-3CDSENST00000584889ENST00000442934TRIM37chr17

57148184

-MSI2chr17

55478740

+
intron-3CDSENST00000584889ENST00000579180TRIM37chr17

57148184

-MSI2chr17

55478740

+
intron-intronENST00000584889ENST00000579505TRIM37chr17

57148184

-MSI2chr17

55478740

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376149TRIM37chr1757148184-ENST00000416426MSI2chr1755478740+258612533271283318
ENST00000376149TRIM37chr1757148184-ENST00000284073MSI2chr1755478740+709612533271283318
ENST00000376149TRIM37chr1757148184-ENST00000322684MSI2chr1755478740+277812533271283318
ENST00000376149TRIM37chr1757148184-ENST00000442934MSI2chr1755478740+270812533271283318
ENST00000376149TRIM37chr1757148184-ENST00000579180MSI2chr1755478740+278312533271283318

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376149ENST00000416426TRIM37chr1757148184-MSI2chr1755478740+0.0081915080.9918085
ENST00000376149ENST00000284073TRIM37chr1757148184-MSI2chr1755478740+0.0008845870.9991154
ENST00000376149ENST00000322684TRIM37chr1757148184-MSI2chr1755478740+0.0057251340.9942749
ENST00000376149ENST00000442934TRIM37chr1757148184-MSI2chr1755478740+0.0060715170.99392843
ENST00000376149ENST00000579180TRIM37chr1757148184-MSI2chr1755478740+0.0054763360.99452364

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Fusion Genomic Features for TRIM37-MSI2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRIM37chr1757148183-MSI2chr1755478739+5.61E-050.999944
TRIM37chr1757148183-MSI2chr1755478739+5.61E-050.999944

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TRIM37-MSI2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57148184/chr17:55478740)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MSI2

Q96DH6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM37chr17:57148184chr17:55478740ENST00000262294-924132_234269965.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57148184chr17:55478740ENST00000393066-925132_234269965.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57148184chr17:55478740ENST00000262294-92415_55269965.0Zinc fingerRING-type%3B degenerate
HgeneTRIM37chr17:57148184chr17:55478740ENST00000262294-92490_132269965.0Zinc fingerB box-type
HgeneTRIM37chr17:57148184chr17:55478740ENST00000376149-92315_55147804.0Zinc fingerRING-type%3B degenerate
HgeneTRIM37chr17:57148184chr17:55478740ENST00000376149-92390_132147804.0Zinc fingerB box-type
HgeneTRIM37chr17:57148184chr17:55478740ENST00000393066-92515_55269965.0Zinc fingerRING-type%3B degenerate
HgeneTRIM37chr17:57148184chr17:55478740ENST00000393066-92590_132269965.0Zinc fingerB box-type
TgeneMSI2chr17:57148184chr17:55478740ENST00000284073414253_2601041951.0Compositional biasNote=Poly-Ala
TgeneMSI2chr17:57148184chr17:55478740ENST00000322684310253_260100252.0Compositional biasNote=Poly-Ala
TgeneMSI2chr17:57148184chr17:55478740ENST0000057918007253_2600152.0Compositional biasNote=Poly-Ala
TgeneMSI2chr17:57148184chr17:55478740ENST00000284073414110_1871041951.0DomainRRM 2
TgeneMSI2chr17:57148184chr17:55478740ENST00000322684310110_187100252.0DomainRRM 2
TgeneMSI2chr17:57148184chr17:55478740ENST0000057918007110_1870152.0DomainRRM 2
TgeneMSI2chr17:57148184chr17:55478740ENST000005791800721_1110152.0DomainRRM 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM37chr17:57148184chr17:55478740ENST00000262294-924419_450269965.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57148184chr17:55478740ENST00000262294-924673_700269965.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57148184chr17:55478740ENST00000376149-923132_234147804.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57148184chr17:55478740ENST00000376149-923419_450147804.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57148184chr17:55478740ENST00000376149-923673_700147804.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57148184chr17:55478740ENST00000393066-925419_450269965.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57148184chr17:55478740ENST00000393066-925673_700269965.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57148184chr17:55478740ENST00000262294-924534_540269965.0Compositional biasNote=Poly-Ser
HgeneTRIM37chr17:57148184chr17:55478740ENST00000262294-924578_581269965.0Compositional biasNote=Poly-Ala
HgeneTRIM37chr17:57148184chr17:55478740ENST00000376149-923534_540147804.0Compositional biasNote=Poly-Ser
HgeneTRIM37chr17:57148184chr17:55478740ENST00000376149-923578_581147804.0Compositional biasNote=Poly-Ala
HgeneTRIM37chr17:57148184chr17:55478740ENST00000393066-925534_540269965.0Compositional biasNote=Poly-Ser
HgeneTRIM37chr17:57148184chr17:55478740ENST00000393066-925578_581269965.0Compositional biasNote=Poly-Ala
HgeneTRIM37chr17:57148184chr17:55478740ENST00000262294-924276_403269965.0DomainMATH
HgeneTRIM37chr17:57148184chr17:55478740ENST00000376149-923276_403147804.0DomainMATH
HgeneTRIM37chr17:57148184chr17:55478740ENST00000393066-925276_403269965.0DomainMATH
TgeneMSI2chr17:57148184chr17:55478740ENST0000028407341421_1111041951.0DomainRRM 1
TgeneMSI2chr17:57148184chr17:55478740ENST0000032268431021_111100252.0DomainRRM 1


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Fusion Gene Sequence for TRIM37-MSI2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94099_94099_1_TRIM37-MSI2_TRIM37_chr17_57148184_ENST00000376149_MSI2_chr17_55478740_ENST00000284073_length(transcript)=7096nt_BP=1253nt
ACAGCGTCCTGCGCGCATGCGCTTCGCAGCTTCTCTCGCCGCCGCGCCCCCAGCTGCTCTGGTTACGGTTGGTGTTTGCGAATTCTCTGC
GGCACCTTCTTCGCTGAACTCCACCGTCAGTTCCATAGGCGCGCGCCCGCGTCACGTGGGCCGAGGTTCCGGCGCGGCTGCTGGCCGGCG
GCTGAGCCGGGAGAAAGGAGCTGCGGCCACCGTTCGCCCTACTTCTGCGCCTCGGGGCGGGCGCGCCGGTAAAAATGGCGAAATGGGGGT
AGGCGGCGCTGGACCTGAAGAGATGGGGCGCGCAGGTGGGGCGGTTGTCAGAGCCCCCTGACGTGGGCGCCGGGCTTTTATCGGCGATTT
GATCTGGCGACCTCGGGCCGGCGCCTAAGAGGTCAGACTGCGGAGCCTGCGGGTCGCCAGCGGCCCCGCCGAGAGCCGGAGGCAATGGAT
GAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCATTGCTCC
AAACTGTGTTGTTTCAGCTGTATTAGGCGCTGGCTGACAGAGCAGAGAGCTCAATGTCCTCATTGCCGTGCTCCACTCCAGCTACGAGAA
CTAGTAAATTGTCGTTGGGCAGAAGAAGTAACACAACAGCTTGATACTCTTCAACTCTGCAGTCTCACCAAACATGAAGAAAATGAAAAG
GACAAATGTGAAAATCACCATGAAAAACTTAGTGTATTTTGCTGGACTTGTAAGAAGTGTATCTGCCATCAGTGTGCACTTTGGGGAGGA
ATGCATGGCGGACATACCTTTAAACCTTTGGCAGAAATTTATGAGCAACACGTCACTAAAGTGAATGAAGAGGTAGCCAAACTTCGTCGG
CGTCTCATGGAACTGATCAGCTTAGTTCAAGAAGTGGAAAGGAATGTAGAAGCTGTAAGAAATGCAAAAGATGAGCGTGTTCGGGAAATT
AGGAATGCAGTGGAGATGATGATTGCACGGTTAGACACACAGCTGAAGAATAAGCTTATAACACTGATGGGTCAGAAGACATCTCTAACC
CAAGAAACAGAGCTTTTGGAATCCTTACTTCAGGAGGTGGAGCACCAGTTGCGGTCTTGTAGTAAGAGTGAGTTGATATCTAAGAGCTCA
GAGATCCTTATGATGTTTCAGCAAGTTCATCGGAAGCCCATGGCATCTTTTGTTACCACTCCTGTTCCACCAGACTTTACCAGATGGTCA
CAAGAACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGG
AAGATGCAATGCTGATGTTTGATAAAACTACCAACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAG
TCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAA
GAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATG
GCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGG
TGGCGGCAGCAAGAGGATCAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACG
GCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGAC
CTTTGATTGCAACGGCCTTTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGC
AAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGA
GATGGCTCACTTCGGATCGAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATA
ACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGA
ATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTA
AGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCC
ATATTTTGGTACCAATTCTGAGACTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGGCGGGAGG
TGGGCGTGAGCTTTCTATTTTGCGTTGTAGAAGAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGTGATGTCT
CTTTGTTAATCTGAGTCTATCTATTTTCGGCAATAAGGTAAGGACGACAGTGTTTTGAGTGTCCTCCTTTTCTATAAGTGCTTTTTTTCT
GTTGAAAGAGGTGATATTATAAGGTTTTTTGAAATTGTGAATTCTAAAAAAGAAATGTTGTAAATACAATTCCATTAACTACATAGAAAC
TATTAAGAAAGAGAGAATCAAAAATATTTTTGTGAGGGAGTCGGTCCCAGGCAGTTTGATGCTCTGTGGAAGGAGGCGGGAAGGGAACGT
TGGCCAAGTCAGTTACTGAGATGAAGATCGCCCAGCTGCCAGGACCACCCCAGGACAAGTTAGAGCACTGTTTAGCTCCTTTGTCTGTGT
GATAGACCTAAGAACTGTATTAGTGTTGTACCAGCCTATTAACCTCTTGTCTGTGCACAGCTTCAAATGTTACCGTCTAGTTAGATTTTT
ATTTAAAATATGAAAAACTGCTTTTCCCAAGATGTTTTTTAAAAACAAAGCTACAATTTTAATATTTAACATATTTAAAGTTTCAAAGCA
CACCTGTTTGGCTTGGGTGGGGGTGGGGTGGGGGGGACATTCTTTTTCAGTCTTAATTTTTAAATATTTGATCATTTTCTATTGTCCAAT
CATTTCAGCACCTCCAAAGGTCCCTAGGACACTTTGCCTCTCTTCTCCCCCTGCCCCCCACCCTGCTCCCACATCTGGGGGCCCATGGGC
CAGGAGTGGATAAGCCTGCATTAATACAACCTTTCTCCATTCACTTTCTATTTACAAATTAGGAAAGCAACCTTTTGGTTTATATATATT
TTTTTTAATACCTCAGTGCTGCAAGTATCACCAGAGAGGCTATGGAAGAATTTTTTTTTAATTTATTGTAGATGTAAACAGAATTTTAAA
AATAAAAAGTATAAACATCACTGCACTGTGACTGGTGGGAAAAACTGACAGTTTCCTCTTTGCACATGTTTAACATTTGGCTGTTATAAT
ATATGGTCCTCGGTTGGGGAAAGATACTTATGATGAAGGATATTTTTTAATTTAACTTTTTTTTAAATATTGGTAATAGGTCGGCAACAG
CAACTATAGAAGTACAACTCAATAGATGGCATTAAAACATATTGTAGTGTGGATATATATTTTTTCTTTTTTAAAATGTGATATTGACGT
TTTATTAATATTTTTTAAATTGTTACGTTTATAAATTTGGTACTTAAGGCACAGCCAGTATGAGACACTGAATGCGACATTTATTATAAA
GAGCTGCTGCACTCCTATTTTTATAAATTTTACTAACAAAGTAGACTAATGTAGACATTCACAGACATGGTAGGGCAAAAGCATCTTCAA
ACTAAAGACTCCAAAATGCTAACTCAGAAAGAAAGAAAAAACCCGTTTTCAATTCTAATGAAACAGCAACAACATTTTTTTTAATTAAAA
AAAAAATCATGTTCTTTGTTTTTCTAATAAAATGTTAGGTTGTTTGGTGAGGTTTTTTTGTTGTTTTTTTCCTTTCTTTGTTTCTTTTCT
TTTCCCCCAAACAACCAGATTAAATGCTGAGCGCTTTTAAAATATCAAAACTTGTTCAAGTCATAAAACAACAAAACATAAGTTTTATTT
AAAAAAAAAAAAAGAAAGAAAAAATAGTAAATTCCCAGAAATTCAGTGTTTAGACGAGGGAATTTAATTCCTATTTTGTCCATGTTGGTG
ATGTACTGTACTTCCCTTCCTTTTCTCTGCATCCCCCATCACCTCATAGAAGACTCTTTGTTGATCATTGTATGTTAATAATGTATAAAA
TGGCTATCTTGTAAGCGTGCTGTCCTGGTACTAGTGTAGCGACTTTTTTTCTCCTCTTTCTTCTAGTACATATTGATAGGTATAACATAA
TTAAGGTTTAAAAAAAATTAGACATAGTTATTCAGATTTAGGACCAGTAAGGATAGAACTTTCTCTTATTTATGAAAAAAAATGCTAATA
ATTTTGGGGCAGTTTTTTCCTTTAATTATTTTTTTCAATTTCAAGTTTAATTTTATTTTAGCTGATCTGATGTGGTTTCAACTAACCCAA
GGTCTCACCATGTTAAAATGCCGGCGGACTCTACGGCGTTTTGTAGATCCCCCCCCCCCCACCCACTGTGAAGGGGTGCCATACTACCTT
AAATGCTAATGCTAGATATGCAAAACTGGATTTTTTTAATTTATTTTTTAAAAGAGGGAGGCATGGTATATTAAAATGATTTTACTAAGA
GAAAAAATATTTTTTTAAGAATGCTCAGAAGAAATTGATAATCTGTGTGAATATGTTTTAGATGTTTATATACCTTTTGAAGAGACCCAG
TAGCCCATAGCACAAATCTTGTGGAAATCCGATATGTTTTAATGTGGCTACCTAGGTTTAAGGTTCACGTTAGTCCCCCCATTCCATCTA
GAAGTCCATTTTGAAAGATTTTTGTAAATTCTTTTAACACTGATGTTTCAGCCTCGTCTTTGTTTCAGTTAAGCTCAATGGCGAACATGG
GAACCACCTTTCGCCTTCCCTGGGGGAGAAACCCTCTTGGCTGATGGCTTTTCCCCGGAATTATCAAACAGCCACCGGGTGACTTTCTGG
CTTCCAGATCCATCTGCCTGAGACCCCCGAACTCCTCTCCTCCCAAGCAGAGGCGAGTGAGTGGCATTAGCTCCCGGACCCATTCCCGGT
CCTAGCTGGGCATGGGGCTGACGGAGATGACCAAGCCTTGGTCTGCTCTCTAGCAGCTTCCACAGACTTGGCTCGTGGCCTTCCTTATAT
CCACTGGGAACAAACAGCCTCGCGCTCTATACCAAACAGCCTCGCGCTCTATCCCAGTCGCCCATTAGCTTGATTCAAACAAAGCCCCAG
CAGGCCTTTGCGTTTTTATCCTTCATAACCTTCATCTTAATTTGAACTTGTAGCTTGGACTTTAAGGTAGCATGGCTCTATTGCTGTCAA
TTTACTGTTTCACTGCACAGCAATCACAGCCAGTGAATGTTACACACATCTTGCTAGACTAGTATAAAAATCATTGGGTAATTGTTGGTT
CTAATGACCTGAAAGGTGTTCAGTTTTTGTTCTTGGTTTTGTTTTGTTTTTGATTTCTTGGGGGTGGGTTTTGCTTGTTGTTCCTTTTCA
TTTGGGGGTTTTTGGGGAAAAAATTTATTTTTGGTTCCAAATAGAAAAACAAAACCTATTTTGATCTTTAGTGCAAACGAGGGCTAGGGA
CTTAGCCTCCTCCACCACCTCCACACTGCTTCATTCTGCCATTCACTCACTGCAGCATATTCAAGAATAAAGCAATATCGTTTACTACAT
TTTTTATTGAAGGTCAGCCATGCTTTCTGTATTATATTGCATATGAAATTGTTTACAAAAGAAACACTAACTCATACTTCTCTTTATTGG
TTGCAAGTGGCACGCAGGAACAGAGGGAGAGTGGGGGGCTGGTGGGGGAGGGGAGATTTTTTTTTTTTTTTCTTGAATGTGCTTCGCAAG
CCAGGCTATCTTCCAAGGAAGGCAGACAGTGGGAGAGCAGAGGGACTGACTGCAGGCAAGCACATTGAAGAAAGACACTGGCGGGTTTCC
CCACCCTCACCCCAAAGCAGAAAACTAGCAGACGTCAGCTCAGCCCCGTCCTGGGCACAGACACTACACAAGGAGACGCTGGAAGTTAAG
CAATACTTTAATACTGTAATATGTTTGTTTTCTTTTTCTTTCTTTTTTTTCTACCAAAAAAAAGTAAGTAAACTAAAACACAAAAACATA
TAAATAAAATCCATCCCTCTTGTCGGGGACCTGCAGGGGGGCAACCTTAATCCAAACACCTGGCTATCAAATAATCAGAATGTATTGTCT
CAGACAGGATTTCAGTTCCGGGAGGCAGGGGCATGATGGGGGAGGGGGCCGGAGGCTGAGAGACAAAAGTTCCAGAGCCTCCCTCGAAGG
TTCTCTACTACTGTATTCTGTACATAATGTACCATCCCATGTGGAATCTGTGAGTGTCCTCTTAAGTAGCGTGGGCTAGCCAATCTGCCG
TTCATGGTGTATTGTAAACTCCGAATTCCATATGTAATAGGATGCAAGTCTAAGCGTTTCATGTGGACATAAATGTATCTAAATAAAACT
TTCCCTAGCACTGTGGCTGACCTCACCCTTACTTTTATACTTTAGTATGAAACTGATGAGAACTTTGGTAGTGAGTATTTTTTTTATATA
TATACATATATATGTACTATCTATATATATATCTCAAGCATCTTTCAGGTCTTTGTGTGTGGCTTTCTTAAAGCCCTGTTGTAAAAAATT
ACTATGTGGATGGCAGTCTCTCACATCACAGATGTGGAAAGTATAATTTTATATTTGTATTTTCAAATAAATAAGTTTGTGAAAGGTTTC

>94099_94099_1_TRIM37-MSI2_TRIM37_chr17_57148184_ENST00000376149_MSI2_chr17_55478740_ENST00000284073_length(amino acids)=318AA_BP=
MTWAPGFYRRFDLATSGRRLRGQTAEPAGRQRPRREPEAMDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQC
PHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVT
KVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRS

--------------------------------------------------------------
>94099_94099_2_TRIM37-MSI2_TRIM37_chr17_57148184_ENST00000376149_MSI2_chr17_55478740_ENST00000322684_length(transcript)=2778nt_BP=1253nt
ACAGCGTCCTGCGCGCATGCGCTTCGCAGCTTCTCTCGCCGCCGCGCCCCCAGCTGCTCTGGTTACGGTTGGTGTTTGCGAATTCTCTGC
GGCACCTTCTTCGCTGAACTCCACCGTCAGTTCCATAGGCGCGCGCCCGCGTCACGTGGGCCGAGGTTCCGGCGCGGCTGCTGGCCGGCG
GCTGAGCCGGGAGAAAGGAGCTGCGGCCACCGTTCGCCCTACTTCTGCGCCTCGGGGCGGGCGCGCCGGTAAAAATGGCGAAATGGGGGT
AGGCGGCGCTGGACCTGAAGAGATGGGGCGCGCAGGTGGGGCGGTTGTCAGAGCCCCCTGACGTGGGCGCCGGGCTTTTATCGGCGATTT
GATCTGGCGACCTCGGGCCGGCGCCTAAGAGGTCAGACTGCGGAGCCTGCGGGTCGCCAGCGGCCCCGCCGAGAGCCGGAGGCAATGGAT
GAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCATTGCTCC
AAACTGTGTTGTTTCAGCTGTATTAGGCGCTGGCTGACAGAGCAGAGAGCTCAATGTCCTCATTGCCGTGCTCCACTCCAGCTACGAGAA
CTAGTAAATTGTCGTTGGGCAGAAGAAGTAACACAACAGCTTGATACTCTTCAACTCTGCAGTCTCACCAAACATGAAGAAAATGAAAAG
GACAAATGTGAAAATCACCATGAAAAACTTAGTGTATTTTGCTGGACTTGTAAGAAGTGTATCTGCCATCAGTGTGCACTTTGGGGAGGA
ATGCATGGCGGACATACCTTTAAACCTTTGGCAGAAATTTATGAGCAACACGTCACTAAAGTGAATGAAGAGGTAGCCAAACTTCGTCGG
CGTCTCATGGAACTGATCAGCTTAGTTCAAGAAGTGGAAAGGAATGTAGAAGCTGTAAGAAATGCAAAAGATGAGCGTGTTCGGGAAATT
AGGAATGCAGTGGAGATGATGATTGCACGGTTAGACACACAGCTGAAGAATAAGCTTATAACACTGATGGGTCAGAAGACATCTCTAACC
CAAGAAACAGAGCTTTTGGAATCCTTACTTCAGGAGGTGGAGCACCAGTTGCGGTCTTGTAGTAAGAGTGAGTTGATATCTAAGAGCTCA
GAGATCCTTATGATGTTTCAGCAAGTTCATCGGAAGCCCATGGCATCTTTTGTTACCACTCCTGTTCCACCAGACTTTACCAGATGGTCA
CAAGAACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGG
AAGATGCAATGCTGATGTTTGATAAAACTACCAACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAG
TCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAA
GAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATG
GCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATCAACTAGC
TCTTAAGAGAGGCATAGCAAAGTGGGGGTTGCTACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTCCAGTCAA
TGCTCACTGAAAGTCTGTCTTAGCTGCCTGTTTGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATTGCTTCAC
TCAATTAAAAAAAAATTATTCTCCAGTCCCCTCCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGTAACGGGG
CCAGAGGGAAACTTCTCACAAACTTCGTAGAGCCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGACCAAACAG
GCTTGTTGGGGACATATCATGGGGTGAGCTTTGAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGTGTCTTAC
GATGGACAGTGATAAAGGTGAACACACAGAGACAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATATAAACACT
ATCTGACTATCTTTGTCTTTTGGGGCCAGTGGCTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTCATCCAGG
TGCTGCCACATGACAGGCACGGTGGGCACCGATCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCTGGCCTTG
CCTGCTGGCACCATTGGAGTAGGAGGGGGTGGAACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTGCCCATCA
CCCTTAGAAGGATCTTTTCCCATGGCTTGACTTCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTACCACTCA
GTTGGACCCTCAAGAGTCACTGCTTTGTCTGTGCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGATGTGAGTG

>94099_94099_2_TRIM37-MSI2_TRIM37_chr17_57148184_ENST00000376149_MSI2_chr17_55478740_ENST00000322684_length(amino acids)=318AA_BP=
MTWAPGFYRRFDLATSGRRLRGQTAEPAGRQRPRREPEAMDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQC
PHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVT
KVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRS

--------------------------------------------------------------
>94099_94099_3_TRIM37-MSI2_TRIM37_chr17_57148184_ENST00000376149_MSI2_chr17_55478740_ENST00000416426_length(transcript)=2586nt_BP=1253nt
ACAGCGTCCTGCGCGCATGCGCTTCGCAGCTTCTCTCGCCGCCGCGCCCCCAGCTGCTCTGGTTACGGTTGGTGTTTGCGAATTCTCTGC
GGCACCTTCTTCGCTGAACTCCACCGTCAGTTCCATAGGCGCGCGCCCGCGTCACGTGGGCCGAGGTTCCGGCGCGGCTGCTGGCCGGCG
GCTGAGCCGGGAGAAAGGAGCTGCGGCCACCGTTCGCCCTACTTCTGCGCCTCGGGGCGGGCGCGCCGGTAAAAATGGCGAAATGGGGGT
AGGCGGCGCTGGACCTGAAGAGATGGGGCGCGCAGGTGGGGCGGTTGTCAGAGCCCCCTGACGTGGGCGCCGGGCTTTTATCGGCGATTT
GATCTGGCGACCTCGGGCCGGCGCCTAAGAGGTCAGACTGCGGAGCCTGCGGGTCGCCAGCGGCCCCGCCGAGAGCCGGAGGCAATGGAT
GAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCATTGCTCC
AAACTGTGTTGTTTCAGCTGTATTAGGCGCTGGCTGACAGAGCAGAGAGCTCAATGTCCTCATTGCCGTGCTCCACTCCAGCTACGAGAA
CTAGTAAATTGTCGTTGGGCAGAAGAAGTAACACAACAGCTTGATACTCTTCAACTCTGCAGTCTCACCAAACATGAAGAAAATGAAAAG
GACAAATGTGAAAATCACCATGAAAAACTTAGTGTATTTTGCTGGACTTGTAAGAAGTGTATCTGCCATCAGTGTGCACTTTGGGGAGGA
ATGCATGGCGGACATACCTTTAAACCTTTGGCAGAAATTTATGAGCAACACGTCACTAAAGTGAATGAAGAGGTAGCCAAACTTCGTCGG
CGTCTCATGGAACTGATCAGCTTAGTTCAAGAAGTGGAAAGGAATGTAGAAGCTGTAAGAAATGCAAAAGATGAGCGTGTTCGGGAAATT
AGGAATGCAGTGGAGATGATGATTGCACGGTTAGACACACAGCTGAAGAATAAGCTTATAACACTGATGGGTCAGAAGACATCTCTAACC
CAAGAAACAGAGCTTTTGGAATCCTTACTTCAGGAGGTGGAGCACCAGTTGCGGTCTTGTAGTAAGAGTGAGTTGATATCTAAGAGCTCA
GAGATCCTTATGATGTTTCAGCAAGTTCATCGGAAGCCCATGGCATCTTTTGTTACCACTCCTGTTCCACCAGACTTTACCAGATGGTCA
CAAGAACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGG
AAGATGCAATGCTGATGTTTGATAAAACTACCAACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAG
TCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAA
GAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATG
GCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGG
TGGCGGCAGCAAGAGGATCAGTCCTGAATAGCTACAGTGCTCAACCGAATTTTGGCGCGCCCGCTTCCCCGGCAGGCTCCAACCCGGCGC
GGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACA
TAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATACCATT
GAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTA
GGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACATCTC
ATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCT
TGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAG
TCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTT
GTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAATTTT

>94099_94099_3_TRIM37-MSI2_TRIM37_chr17_57148184_ENST00000376149_MSI2_chr17_55478740_ENST00000416426_length(amino acids)=318AA_BP=
MTWAPGFYRRFDLATSGRRLRGQTAEPAGRQRPRREPEAMDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQC
PHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVT
KVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRS

--------------------------------------------------------------
>94099_94099_4_TRIM37-MSI2_TRIM37_chr17_57148184_ENST00000376149_MSI2_chr17_55478740_ENST00000442934_length(transcript)=2708nt_BP=1253nt
ACAGCGTCCTGCGCGCATGCGCTTCGCAGCTTCTCTCGCCGCCGCGCCCCCAGCTGCTCTGGTTACGGTTGGTGTTTGCGAATTCTCTGC
GGCACCTTCTTCGCTGAACTCCACCGTCAGTTCCATAGGCGCGCGCCCGCGTCACGTGGGCCGAGGTTCCGGCGCGGCTGCTGGCCGGCG
GCTGAGCCGGGAGAAAGGAGCTGCGGCCACCGTTCGCCCTACTTCTGCGCCTCGGGGCGGGCGCGCCGGTAAAAATGGCGAAATGGGGGT
AGGCGGCGCTGGACCTGAAGAGATGGGGCGCGCAGGTGGGGCGGTTGTCAGAGCCCCCTGACGTGGGCGCCGGGCTTTTATCGGCGATTT
GATCTGGCGACCTCGGGCCGGCGCCTAAGAGGTCAGACTGCGGAGCCTGCGGGTCGCCAGCGGCCCCGCCGAGAGCCGGAGGCAATGGAT
GAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCATTGCTCC
AAACTGTGTTGTTTCAGCTGTATTAGGCGCTGGCTGACAGAGCAGAGAGCTCAATGTCCTCATTGCCGTGCTCCACTCCAGCTACGAGAA
CTAGTAAATTGTCGTTGGGCAGAAGAAGTAACACAACAGCTTGATACTCTTCAACTCTGCAGTCTCACCAAACATGAAGAAAATGAAAAG
GACAAATGTGAAAATCACCATGAAAAACTTAGTGTATTTTGCTGGACTTGTAAGAAGTGTATCTGCCATCAGTGTGCACTTTGGGGAGGA
ATGCATGGCGGACATACCTTTAAACCTTTGGCAGAAATTTATGAGCAACACGTCACTAAAGTGAATGAAGAGGTAGCCAAACTTCGTCGG
CGTCTCATGGAACTGATCAGCTTAGTTCAAGAAGTGGAAAGGAATGTAGAAGCTGTAAGAAATGCAAAAGATGAGCGTGTTCGGGAAATT
AGGAATGCAGTGGAGATGATGATTGCACGGTTAGACACACAGCTGAAGAATAAGCTTATAACACTGATGGGTCAGAAGACATCTCTAACC
CAAGAAACAGAGCTTTTGGAATCCTTACTTCAGGAGGTGGAGCACCAGTTGCGGTCTTGTAGTAAGAGTGAGTTGATATCTAAGAGCTCA
GAGATCCTTATGATGTTTCAGCAAGTTCATCGGAAGCCCATGGCATCTTTTGTTACCACTCCTGTTCCACCAGACTTTACCAGATGGTCA
CAAGAACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGG
AAGATGCAATGCTGATGTTTGATAAAACTACCAACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAG
TCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAA
GAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATG
GCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGG
TGGCGGCAGCAAGAGGATCAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACG
GCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGAC
CTTTGATTGCAACGGCCTTTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGC
AAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGA
GATGGCTCACTTCGGATCGAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATA
ACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGA
ATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTA
AGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCC
ATATTTTGGTACCAATTCTGAGACTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGGCGGGAGG
TGGGCGTGAGCTTTCTATTTTGCGTTGTAGAAGAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGTGATGTCT
CTTTGTTAATCTGAGTCTATCTATTTTCGGCAATAAGGTAAGGACGACAGTGTTTTGAGTGTCCTCCTTTTCTATAAGTGCTTTTTTTCT

>94099_94099_4_TRIM37-MSI2_TRIM37_chr17_57148184_ENST00000376149_MSI2_chr17_55478740_ENST00000442934_length(amino acids)=318AA_BP=
MTWAPGFYRRFDLATSGRRLRGQTAEPAGRQRPRREPEAMDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQC
PHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVT
KVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRS

--------------------------------------------------------------
>94099_94099_5_TRIM37-MSI2_TRIM37_chr17_57148184_ENST00000376149_MSI2_chr17_55478740_ENST00000579180_length(transcript)=2783nt_BP=1253nt
ACAGCGTCCTGCGCGCATGCGCTTCGCAGCTTCTCTCGCCGCCGCGCCCCCAGCTGCTCTGGTTACGGTTGGTGTTTGCGAATTCTCTGC
GGCACCTTCTTCGCTGAACTCCACCGTCAGTTCCATAGGCGCGCGCCCGCGTCACGTGGGCCGAGGTTCCGGCGCGGCTGCTGGCCGGCG
GCTGAGCCGGGAGAAAGGAGCTGCGGCCACCGTTCGCCCTACTTCTGCGCCTCGGGGCGGGCGCGCCGGTAAAAATGGCGAAATGGGGGT
AGGCGGCGCTGGACCTGAAGAGATGGGGCGCGCAGGTGGGGCGGTTGTCAGAGCCCCCTGACGTGGGCGCCGGGCTTTTATCGGCGATTT
GATCTGGCGACCTCGGGCCGGCGCCTAAGAGGTCAGACTGCGGAGCCTGCGGGTCGCCAGCGGCCCCGCCGAGAGCCGGAGGCAATGGAT
GAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCATTGCTCC
AAACTGTGTTGTTTCAGCTGTATTAGGCGCTGGCTGACAGAGCAGAGAGCTCAATGTCCTCATTGCCGTGCTCCACTCCAGCTACGAGAA
CTAGTAAATTGTCGTTGGGCAGAAGAAGTAACACAACAGCTTGATACTCTTCAACTCTGCAGTCTCACCAAACATGAAGAAAATGAAAAG
GACAAATGTGAAAATCACCATGAAAAACTTAGTGTATTTTGCTGGACTTGTAAGAAGTGTATCTGCCATCAGTGTGCACTTTGGGGAGGA
ATGCATGGCGGACATACCTTTAAACCTTTGGCAGAAATTTATGAGCAACACGTCACTAAAGTGAATGAAGAGGTAGCCAAACTTCGTCGG
CGTCTCATGGAACTGATCAGCTTAGTTCAAGAAGTGGAAAGGAATGTAGAAGCTGTAAGAAATGCAAAAGATGAGCGTGTTCGGGAAATT
AGGAATGCAGTGGAGATGATGATTGCACGGTTAGACACACAGCTGAAGAATAAGCTTATAACACTGATGGGTCAGAAGACATCTCTAACC
CAAGAAACAGAGCTTTTGGAATCCTTACTTCAGGAGGTGGAGCACCAGTTGCGGTCTTGTAGTAAGAGTGAGTTGATATCTAAGAGCTCA
GAGATCCTTATGATGTTTCAGCAAGTTCATCGGAAGCCCATGGCATCTTTTGTTACCACTCCTGTTCCACCAGACTTTACCAGATGGTCA
CAAGAACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGG
AAGATGCAATGCTGATGTTTGATAAAACTACCAACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAG
TCTGTGAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAA
GAGGCCGGGCCCGGGGACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATG
GCCGTGGCTACCCCGGATTTGCTCCAAGCTATGGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATCAACTAGC
TCTTAAGAGAGGCATAGCAAAGTGGGGGTTGCTACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTCCAGTCAA
TGCTCACTGAAAGTCTGTCTTAGCTGCCTGTTTGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATTGCTTCAC
TCAATTAAAAAAAAATTATTCTCCAGTCCCCTCCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGTAACGGGG
CCAGAGGGAAACTTCTCACAAACTTCGTAGAGCCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGACCAAACAG
GCTTGTTGGGGACATATCATGGGGTGAGCTTTGAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGTGTCTTAC
GATGGACAGTGATAAAGGTGAACACACAGAGACAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATATAAACACT
ATCTGACTATCTTTGTCTTTTGGGGCCAGTGGCTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTCATCCAGG
TGCTGCCACATGACAGGCACGGTGGGCACCGATCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCTGGCCTTG
CCTGCTGGCACCATTGGAGTAGGAGGGGGTGGAACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTGCCCATCA
CCCTTAGAAGGATCTTTTCCCATGGCTTGACTTCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTACCACTCA
GTTGGACCCTCAAGAGTCACTGCTTTGTCTGTGCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGATGTGAGTG

>94099_94099_5_TRIM37-MSI2_TRIM37_chr17_57148184_ENST00000376149_MSI2_chr17_55478740_ENST00000579180_length(amino acids)=318AA_BP=
MTWAPGFYRRFDLATSGRRLRGQTAEPAGRQRPRREPEAMDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQC
PHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVT
KVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRIM37-MSI2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIM37-MSI2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIM37-MSI2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource