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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIO-CDH18 (FusionGDB2 ID:94194)

Fusion Gene Summary for TRIO-CDH18

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO-CDH18
Fusion gene ID: 94194
HgeneTgene
Gene symbol

TRIO

CDH18

Gene ID

7204

1016

Gene nametrio Rho guanine nucleotide exchange factorcadherin 18
SynonymsARHGEF23|MEBAS|MRD44|tgatCDH14|CDH14L|CDH24
Cytomap

5p15.2

5p14.3

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)cadherin-18cadherin 18, type 2cadherin-14cadherin-like 24ey-cadherin
Modification date2020031320200313
UniProtAcc

TRIOBP

Q13634

Ensembl transtripts involved in fusion geneENST00000344204, ENST00000537187, 
ENST00000344135, ENST00000509967, 
ENST00000515710, 		ENST00000510297, 
ENST00000274170, ENST00000382275, 
ENST00000502796, ENST00000506372, 
ENST00000507958, ENST00000511273, 
Fusion gene scores* DoF score34 X 28 X 12=1142413 X 11 X 6=858
# samples 3513
** MAII scorelog2(35/11424*10)=-5.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/858*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIO [Title/Abstract] AND CDH18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIO(14420130)-CDH18(19612710), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRIO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDH18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2G-01ATRIOchr5

14420130

-CDH18chr5

19612710

-
ChimerDB4SARCTCGA-DX-AB2G-01ATRIOchr5

14420130

+CDH18chr5

19612710

-


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Fusion Gene ORF analysis for TRIO-CDH18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344204ENST00000510297TRIOchr5

14420130

+CDH18chr5

19612710

-
5CDS-intronENST00000537187ENST00000510297TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000344204ENST00000274170TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000344204ENST00000382275TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000344204ENST00000502796TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000344204ENST00000506372TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000344204ENST00000507958TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000344204ENST00000511273TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000537187ENST00000274170TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000537187ENST00000382275TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000537187ENST00000502796TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000537187ENST00000506372TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000537187ENST00000507958TRIOchr5

14420130

+CDH18chr5

19612710

-
In-frameENST00000537187ENST00000511273TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000344135ENST00000274170TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000344135ENST00000382275TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000344135ENST00000502796TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000344135ENST00000506372TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000344135ENST00000507958TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000344135ENST00000511273TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000509967ENST00000274170TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000509967ENST00000382275TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000509967ENST00000502796TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000509967ENST00000506372TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000509967ENST00000507958TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000509967ENST00000511273TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000515710ENST00000274170TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000515710ENST00000382275TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000515710ENST00000502796TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000515710ENST00000506372TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000515710ENST00000507958TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-3CDSENST00000515710ENST00000511273TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-intronENST00000344135ENST00000510297TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-intronENST00000509967ENST00000510297TRIOchr5

14420130

+CDH18chr5

19612710

-
intron-intronENST00000515710ENST00000510297TRIOchr5

14420130

+CDH18chr5

19612710

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344204TRIOchr514420130+ENST00000382275CDH18chr519612710-715152272469562310
ENST00000344204TRIOchr514420130+ENST00000507958CDH18chr519612710-713552272469562310
ENST00000344204TRIOchr514420130+ENST00000502796CDH18chr519612710-649552272463082094
ENST00000344204TRIOchr514420130+ENST00000511273CDH18chr519612710-652452272463562110
ENST00000344204TRIOchr514420130+ENST00000274170CDH18chr519612710-695752272469562310
ENST00000344204TRIOchr514420130+ENST00000506372CDH18chr519612710-650452272463112095
ENST00000537187TRIOchr514420130+ENST00000382275CDH18chr519612710-71335209669382310
ENST00000537187TRIOchr514420130+ENST00000507958CDH18chr519612710-71175209669382310
ENST00000537187TRIOchr514420130+ENST00000502796CDH18chr519612710-64775209662902094
ENST00000537187TRIOchr514420130+ENST00000511273CDH18chr519612710-65065209663382110
ENST00000537187TRIOchr514420130+ENST00000274170CDH18chr519612710-69395209669382310
ENST00000537187TRIOchr514420130+ENST00000506372CDH18chr519612710-64865209662932095

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344204ENST00000382275TRIOchr514420130+CDH18chr519612710-0.0053547840.99464524
ENST00000344204ENST00000507958TRIOchr514420130+CDH18chr519612710-0.0055418860.9944581
ENST00000344204ENST00000502796TRIOchr514420130+CDH18chr519612710-0.0052736290.99472636
ENST00000344204ENST00000511273TRIOchr514420130+CDH18chr519612710-0.0043153910.9956846
ENST00000344204ENST00000274170TRIOchr514420130+CDH18chr519612710-0.0057503910.9942496
ENST00000344204ENST00000506372TRIOchr514420130+CDH18chr519612710-0.0050388280.99496114
ENST00000537187ENST00000382275TRIOchr514420130+CDH18chr519612710-0.00530110.9946989
ENST00000537187ENST00000507958TRIOchr514420130+CDH18chr519612710-0.0054708730.9945292
ENST00000537187ENST00000502796TRIOchr514420130+CDH18chr519612710-0.0052099810.9947901
ENST00000537187ENST00000511273TRIOchr514420130+CDH18chr519612710-0.0042735760.99572647
ENST00000537187ENST00000274170TRIOchr514420130+CDH18chr519612710-0.0056770630.9943229
ENST00000537187ENST00000506372TRIOchr514420130+CDH18chr519612710-0.0049898540.99501014

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Fusion Genomic Features for TRIO-CDH18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIO-CDH18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:14420130/chr5:19612710)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

TRIOBP

CDH18

Q13634

2365FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+3457715_71817343098.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+3458715_71817342922.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34571292_146717343098.0DomainDH 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34571480_159117343098.0DomainPH 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34571656_172117343098.0DomainSH3 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+345765_21017343098.0DomainCRAL-TRIO
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34581292_146717342922.0DomainDH 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34581480_159117342922.0DomainPH 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34581656_172117342922.0DomainSH3 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+345865_21017342922.0DomainCRAL-TRIO
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34571109_121617343098.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+3457311_41817343098.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+3457538_64417343098.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+3457878_98417343098.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34581109_121617342922.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+3458311_41817342922.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+3458538_64417342922.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+3458878_98417342922.0RepeatNote=Spectrin 3
TgeneCDH18chr5:14420130chr5:19612710ENST00000274170413269_383214791.0DomainCadherin 3
TgeneCDH18chr5:14420130chr5:19612710ENST00000274170413384_486214791.0DomainCadherin 4
TgeneCDH18chr5:14420130chr5:19612710ENST00000274170413487_608214791.0DomainCadherin 5
TgeneCDH18chr5:14420130chr5:19612710ENST00000382275413269_383214791.0DomainCadherin 3
TgeneCDH18chr5:14420130chr5:19612710ENST00000382275413384_486214791.0DomainCadherin 4
TgeneCDH18chr5:14420130chr5:19612710ENST00000382275413487_608214791.0DomainCadherin 5
TgeneCDH18chr5:14420130chr5:19612710ENST00000502796413269_383214595.6666666666666DomainCadherin 3
TgeneCDH18chr5:14420130chr5:19612710ENST00000502796413384_486214595.6666666666666DomainCadherin 4
TgeneCDH18chr5:14420130chr5:19612710ENST00000502796413487_608214595.6666666666666DomainCadherin 5
TgeneCDH18chr5:14420130chr5:19612710ENST00000507958615269_383214791.0DomainCadherin 3
TgeneCDH18chr5:14420130chr5:19612710ENST00000507958615384_486214791.0DomainCadherin 4
TgeneCDH18chr5:14420130chr5:19612710ENST00000507958615487_608214791.0DomainCadherin 5
TgeneCDH18chr5:14420130chr5:19612710ENST00000274170413637_790214791.0Topological domainCytoplasmic
TgeneCDH18chr5:14420130chr5:19612710ENST00000382275413637_790214791.0Topological domainCytoplasmic
TgeneCDH18chr5:14420130chr5:19612710ENST00000502796413637_790214595.6666666666666Topological domainCytoplasmic
TgeneCDH18chr5:14420130chr5:19612710ENST00000507958615637_790214791.0Topological domainCytoplasmic
TgeneCDH18chr5:14420130chr5:19612710ENST00000274170413609_636214791.0TransmembraneHelical
TgeneCDH18chr5:14420130chr5:19612710ENST00000382275413609_636214791.0TransmembraneHelical
TgeneCDH18chr5:14420130chr5:19612710ENST00000502796413609_636214595.6666666666666TransmembraneHelical
TgeneCDH18chr5:14420130chr5:19612710ENST00000507958615609_636214791.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1101845_18500597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1102292_23120597.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1102545_25510597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+110715_7180597.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34571845_185017343098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34572292_231217343098.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34572545_255117343098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34581845_185017342922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34582292_231217342922.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34582545_255117342922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1101292_14670597.0DomainDH 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1101480_15910597.0DomainPH 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1101656_17210597.0DomainSH3 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1101969_21450597.0DomainDH 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1102157_22710597.0DomainPH 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1102551_26160597.0DomainSH3 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1102685_27750597.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1102796_30520597.0DomainProtein kinase
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+11065_2100597.0DomainCRAL-TRIO
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34571969_214517343098.0DomainDH 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34572157_227117343098.0DomainPH 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34572551_261617343098.0DomainSH3 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34572685_277517343098.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34572796_305217343098.0DomainProtein kinase
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34581969_214517342922.0DomainDH 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34582157_227117342922.0DomainPH 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34582551_261617342922.0DomainSH3 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34582685_277517342922.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34582796_305217342922.0DomainProtein kinase
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1102802_28100597.0Nucleotide bindingATP
HgeneTRIOchr5:14420130chr5:19612710ENST00000344204+34572802_281017343098.0Nucleotide bindingATP
HgeneTRIOchr5:14420130chr5:19612710ENST00000537187+34582802_281017342922.0Nucleotide bindingATP
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+1101109_12160597.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+110311_4180597.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+110538_6440597.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14420130chr5:19612710ENST00000344135+110878_9840597.0RepeatNote=Spectrin 3
TgeneCDH18chr5:14420130chr5:19612710ENST00000274170413160_268214791.0DomainCadherin 2
TgeneCDH18chr5:14420130chr5:19612710ENST0000027417041354_159214791.0DomainCadherin 1
TgeneCDH18chr5:14420130chr5:19612710ENST00000382275413160_268214791.0DomainCadherin 2
TgeneCDH18chr5:14420130chr5:19612710ENST0000038227541354_159214791.0DomainCadherin 1
TgeneCDH18chr5:14420130chr5:19612710ENST00000502796413160_268214595.6666666666666DomainCadherin 2
TgeneCDH18chr5:14420130chr5:19612710ENST0000050279641354_159214595.6666666666666DomainCadherin 1
TgeneCDH18chr5:14420130chr5:19612710ENST00000507958615160_268214791.0DomainCadherin 2
TgeneCDH18chr5:14420130chr5:19612710ENST0000050795861554_159214791.0DomainCadherin 1
TgeneCDH18chr5:14420130chr5:19612710ENST0000027417041354_608214791.0Topological domainExtracellular
TgeneCDH18chr5:14420130chr5:19612710ENST0000038227541354_608214791.0Topological domainExtracellular
TgeneCDH18chr5:14420130chr5:19612710ENST0000050279641354_608214595.6666666666666Topological domainExtracellular
TgeneCDH18chr5:14420130chr5:19612710ENST0000050795861554_608214791.0Topological domainExtracellular


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Fusion Gene Sequence for TRIO-CDH18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94194_94194_1_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000274170_length(transcript)=6957nt_BP=5227nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGAC
CTTCCCTCAGAGCTGCAGGACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGC
CAAGATGGGAAGTCGCTCCTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAG
GCCGTGCACCATGTCCTGGATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTG
CATCAGAGGCTGCAGCTGTGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAA
CATACAGGTGTGGGGAAATCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACC
AATGCGGATAAATTACTGGAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTG
GAAGACCGGATTCAAGATTTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAG
CTGTGGACGTGGCTGGAGGAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGC
TTTGGCCAGCAGCAGCAGACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCC
ATCTCCAGTAACAAGACCCCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAG
GAGCTCTTCCAGGAGCGCAAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTC
GAGTCTTGGAATGATGAGCTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCA
GACAAAGCCTTGACCATGAACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCT
GGTGTGGAGCTGCTGTGTGATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTG
GATTTAGCCGCAGAGCAGCATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGG
ATCCGCAACGGAGAGTCCATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAG
TTCCAGCATGCCATTGAGAAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATG
GACATGATCCGGGACTGCGCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCC
TCTGTCGCTTTCTACAAAACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGC
GGGGCGGATAAGCTGGGCCCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAG
GCTTGCACCCTTGCTCGGAGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATC
AAAGCTCCTGAACAGCAAGTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGA
CGGCTGGACCAGTGTCAGCAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTT
TCCACACACACCTCCACGGGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACC
AAAGAGAGAGTGAAGCTATTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACT
GCTGTGGATAAGAGGTACAGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCC
AACAAATCGAGTAAAAGTCTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTT
AATGAAGAGAAGCGGAAATCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGG
GAATGTATGGATACGTACCTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGA
AACATGCAAGAAATCTACGAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGT
TTTGTTACTTGGGCAGACAAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGG
TCCTATTTTGACGAGATACAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTAT
CAGCTCCTTTTAAAAGAGCTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAG
CGAGCCAATGATGCCATGCACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTC
CAAGTGTGGGACCCAAAAACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTG
AAAGATTCCAGTGGGAGAAGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCT
TGCAAATTTGCACTGTGGGTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGG
ATAAAGCATATCCGCGAAGTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCC
GCCACAAGACAGAAGGGAAGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCA
CGGACGTCTCAGAACACGCTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGC
AACGAGCTGACCATCCGACGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGAC
CGCTCCCCAGCGGCAGAAGGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAAC
CACAAAGGAGTTATTAGAACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCT
GGGCAAGTTGGAGGGCTTTCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACAC
TATCAGCTATATGTTCCTGAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGAC
ATGACCTACTCCATCATAAATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAG
AAGCCACTGAACTATGAGAAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGT
CCTTTTAAAGATGCTACTATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTC
TACGAAAATGCCAAGATTGGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAAC
TACAATGTTGAAGACGACAGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCA
TGGTACAACATCACAGTCACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAAT
GACAATCCACCCGAACTTGCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACT
GATAAAGATGATTTTGCCAATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAAT
GAAGATAACACAGCCAGCATTCTGACAAGGCGGAGGAGATTTAGTCGAACTGTTCAGGATGTGTATTATCTGCCCATTATGATCTCTGAT
GGTGGAATCCCCTCTCTCAGCAGCAGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGCCATGCA
GAAGCCTTCCTGTCCTCGGCTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTT
TTTATCACCCTGAGGCGCAGCAAAAAAGAGCCCTTGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGATGAAGGA
GGCGGAGAGGAAGACACAGAGGCCTTTGACATCACAGCCTTGAGGAATCCTTCTGCTGCTGAGGAGCTCAAGTACCGGAGGGATATCAGA
CCTGAAGTGAAGCTCACTCCCAGACACCAGACATCATCCACCCTGGAAAGCATAGATGTTCAGGAATTTATTAAGCAAAGACTGGCAGAA
GCAGACCTAGACCCTAGCGTTCCCCCTTATGACTCTCTTCAGACTTATGCCTATGAGGGTCAGAGATCAGAAGCTGGGTCTATCAGCTCG
CTGGATTCAGCAACGACACAATCAGACCAGGATTATCACTACCTTGGAGACTGGGGACCCGAGTTTAAAAAGTTAGCTGAACTCTATGGA

>94194_94194_1_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000274170_length(amino acids)=2310AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASIL
TRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSK
KEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVP

--------------------------------------------------------------
>94194_94194_2_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000382275_length(transcript)=7151nt_BP=5227nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGAC
CTTCCCTCAGAGCTGCAGGACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGC
CAAGATGGGAAGTCGCTCCTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAG
GCCGTGCACCATGTCCTGGATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTG
CATCAGAGGCTGCAGCTGTGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAA
CATACAGGTGTGGGGAAATCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACC
AATGCGGATAAATTACTGGAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTG
GAAGACCGGATTCAAGATTTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAG
CTGTGGACGTGGCTGGAGGAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGC
TTTGGCCAGCAGCAGCAGACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCC
ATCTCCAGTAACAAGACCCCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAG
GAGCTCTTCCAGGAGCGCAAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTC
GAGTCTTGGAATGATGAGCTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCA
GACAAAGCCTTGACCATGAACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCT
GGTGTGGAGCTGCTGTGTGATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTG
GATTTAGCCGCAGAGCAGCATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGG
ATCCGCAACGGAGAGTCCATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAG
TTCCAGCATGCCATTGAGAAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATG
GACATGATCCGGGACTGCGCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCC
TCTGTCGCTTTCTACAAAACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGC
GGGGCGGATAAGCTGGGCCCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAG
GCTTGCACCCTTGCTCGGAGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATC
AAAGCTCCTGAACAGCAAGTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGA
CGGCTGGACCAGTGTCAGCAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTT
TCCACACACACCTCCACGGGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACC
AAAGAGAGAGTGAAGCTATTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACT
GCTGTGGATAAGAGGTACAGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCC
AACAAATCGAGTAAAAGTCTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTT
AATGAAGAGAAGCGGAAATCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGG
GAATGTATGGATACGTACCTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGA
AACATGCAAGAAATCTACGAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGT
TTTGTTACTTGGGCAGACAAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGG
TCCTATTTTGACGAGATACAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTAT
CAGCTCCTTTTAAAAGAGCTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAG
CGAGCCAATGATGCCATGCACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTC
CAAGTGTGGGACCCAAAAACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTG
AAAGATTCCAGTGGGAGAAGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCT
TGCAAATTTGCACTGTGGGTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGG
ATAAAGCATATCCGCGAAGTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCC
GCCACAAGACAGAAGGGAAGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCA
CGGACGTCTCAGAACACGCTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGC
AACGAGCTGACCATCCGACGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGAC
CGCTCCCCAGCGGCAGAAGGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAAC
CACAAAGGAGTTATTAGAACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCT
GGGCAAGTTGGAGGGCTTTCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACAC
TATCAGCTATATGTTCCTGAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGAC
ATGACCTACTCCATCATAAATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAG
AAGCCACTGAACTATGAGAAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGT
CCTTTTAAAGATGCTACTATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTC
TACGAAAATGCCAAGATTGGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAAC
TACAATGTTGAAGACGACAGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCA
TGGTACAACATCACAGTCACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAAT
GACAATCCACCCGAACTTGCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACT
GATAAAGATGATTTTGCCAATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAAT
GAAGATAACACAGCCAGCATTCTGACAAGGCGGAGGAGATTTAGTCGAACTGTTCAGGATGTGTATTATCTGCCCATTATGATCTCTGAT
GGTGGAATCCCCTCTCTCAGCAGCAGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGCCATGCA
GAAGCCTTCCTGTCCTCGGCTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTT
TTTATCACCCTGAGGCGCAGCAAAAAAGAGCCCTTGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGATGAAGGA
GGCGGAGAGGAAGACACAGAGGCCTTTGACATCACAGCCTTGAGGAATCCTTCTGCTGCTGAGGAGCTCAAGTACCGGAGGGATATCAGA
CCTGAAGTGAAGCTCACTCCCAGACACCAGACATCATCCACCCTGGAAAGCATAGATGTTCAGGAATTTATTAAGCAAAGACTGGCAGAA
GCAGACCTAGACCCTAGCGTTCCCCCTTATGACTCTCTTCAGACTTATGCCTATGAGGGTCAGAGATCAGAAGCTGGGTCTATCAGCTCG
CTGGATTCAGCAACGACACAATCAGACCAGGATTATCACTACCTTGGAGACTGGGGACCCGAGTTTAAAAAGTTAGCTGAACTCTATGGA
GAAATAGAATCTGAAAGAACAACTTAGGGGGTCAGTTCTTGCAACCTTGTGGAATTTGCTTCCTGAGTAAGTGGATATACAACCTCAGCA
ATGACAAGGAAGAAGTGTGGAAACAGTACTTGGAACTGAGGAAGCTGGACACAGCTCCTGTAGAAACAAGTGCCCTTTTCATGATCGAAA

>94194_94194_2_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000382275_length(amino acids)=2310AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASIL
TRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSK
KEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVP

--------------------------------------------------------------
>94194_94194_3_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000502796_length(transcript)=6495nt_BP=5227nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGAC
CTTCCCTCAGAGCTGCAGGACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGC
CAAGATGGGAAGTCGCTCCTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAG
GCCGTGCACCATGTCCTGGATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTG
CATCAGAGGCTGCAGCTGTGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAA
CATACAGGTGTGGGGAAATCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACC
AATGCGGATAAATTACTGGAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTG
GAAGACCGGATTCAAGATTTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAG
CTGTGGACGTGGCTGGAGGAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGC
TTTGGCCAGCAGCAGCAGACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCC
ATCTCCAGTAACAAGACCCCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAG
GAGCTCTTCCAGGAGCGCAAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTC
GAGTCTTGGAATGATGAGCTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCA
GACAAAGCCTTGACCATGAACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCT
GGTGTGGAGCTGCTGTGTGATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTG
GATTTAGCCGCAGAGCAGCATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGG
ATCCGCAACGGAGAGTCCATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAG
TTCCAGCATGCCATTGAGAAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATG
GACATGATCCGGGACTGCGCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCC
TCTGTCGCTTTCTACAAAACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGC
GGGGCGGATAAGCTGGGCCCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAG
GCTTGCACCCTTGCTCGGAGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATC
AAAGCTCCTGAACAGCAAGTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGA
CGGCTGGACCAGTGTCAGCAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTT
TCCACACACACCTCCACGGGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACC
AAAGAGAGAGTGAAGCTATTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACT
GCTGTGGATAAGAGGTACAGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCC
AACAAATCGAGTAAAAGTCTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTT
AATGAAGAGAAGCGGAAATCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGG
GAATGTATGGATACGTACCTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGA
AACATGCAAGAAATCTACGAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGT
TTTGTTACTTGGGCAGACAAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGG
TCCTATTTTGACGAGATACAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTAT
CAGCTCCTTTTAAAAGAGCTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAG
CGAGCCAATGATGCCATGCACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTC
CAAGTGTGGGACCCAAAAACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTG
AAAGATTCCAGTGGGAGAAGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCT
TGCAAATTTGCACTGTGGGTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGG
ATAAAGCATATCCGCGAAGTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCC
GCCACAAGACAGAAGGGAAGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCA
CGGACGTCTCAGAACACGCTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGC
AACGAGCTGACCATCCGACGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGAC
CGCTCCCCAGCGGCAGAAGGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAAC
CACAAAGGAGTTATTAGAACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCT
GGGCAAGTTGGAGGGCTTTCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACAC
TATCAGCTATATGTTCCTGAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGAC
ATGACCTACTCCATCATAAATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAG
AAGCCACTGAACTATGAGAAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGT
CCTTTTAAAGATGCTACTATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTC
TACGAAAATGCCAAGATTGGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAAC
TACAATGTTGAAGACGACAGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCA
TGGTACAACATCACAGTCACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAAT
GACAATCCACCCGAACTTGCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACT
GATAAAGATGATTTTGCCAATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAAT
GAAGCAGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGCCATGCAGAAGCCTTCCTGTCCTCGG
CTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTTTTTATCACCCTGAGGCGCA
GCAAAAAAGAGCCCTTGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGATGAAGGAGGCGGAGAGGAAGACACAG

>94194_94194_3_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000502796_length(amino acids)=2094AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEAAAPSPS

--------------------------------------------------------------
>94194_94194_4_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000506372_length(transcript)=6504nt_BP=5227nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGAC
CTTCCCTCAGAGCTGCAGGACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGC
CAAGATGGGAAGTCGCTCCTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAG
GCCGTGCACCATGTCCTGGATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTG
CATCAGAGGCTGCAGCTGTGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAA
CATACAGGTGTGGGGAAATCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACC
AATGCGGATAAATTACTGGAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTG
GAAGACCGGATTCAAGATTTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAG
CTGTGGACGTGGCTGGAGGAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGC
TTTGGCCAGCAGCAGCAGACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCC
ATCTCCAGTAACAAGACCCCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAG
GAGCTCTTCCAGGAGCGCAAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTC
GAGTCTTGGAATGATGAGCTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCA
GACAAAGCCTTGACCATGAACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCT
GGTGTGGAGCTGCTGTGTGATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTG
GATTTAGCCGCAGAGCAGCATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGG
ATCCGCAACGGAGAGTCCATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAG
TTCCAGCATGCCATTGAGAAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATG
GACATGATCCGGGACTGCGCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCC
TCTGTCGCTTTCTACAAAACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGC
GGGGCGGATAAGCTGGGCCCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAG
GCTTGCACCCTTGCTCGGAGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATC
AAAGCTCCTGAACAGCAAGTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGA
CGGCTGGACCAGTGTCAGCAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTT
TCCACACACACCTCCACGGGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACC
AAAGAGAGAGTGAAGCTATTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACT
GCTGTGGATAAGAGGTACAGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCC
AACAAATCGAGTAAAAGTCTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTT
AATGAAGAGAAGCGGAAATCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGG
GAATGTATGGATACGTACCTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGA
AACATGCAAGAAATCTACGAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGT
TTTGTTACTTGGGCAGACAAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGG
TCCTATTTTGACGAGATACAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTAT
CAGCTCCTTTTAAAAGAGCTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAG
CGAGCCAATGATGCCATGCACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTC
CAAGTGTGGGACCCAAAAACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTG
AAAGATTCCAGTGGGAGAAGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCT
TGCAAATTTGCACTGTGGGTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGG
ATAAAGCATATCCGCGAAGTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCC
GCCACAAGACAGAAGGGAAGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCA
CGGACGTCTCAGAACACGCTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGC
AACGAGCTGACCATCCGACGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGAC
CGCTCCCCAGCGGCAGAAGGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAAC
CACAAAGGAGTTATTAGAACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCT
GGGCAAGTTGGAGGGCTTTCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACAC
TATCAGCTATATGTTCCTGAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGAC
ATGACCTACTCCATCATAAATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAG
AAGCCACTGAACTATGAGAAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGT
CCTTTTAAAGATGCTACTATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTC
TACGAAAATGCCAAGATTGGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAAC
TACAATGTTGAAGACGACAGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCA
TGGTACAACATCACAGTCACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAAT
GACAATCCACCCGAACTTGCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACT
GATAAAGATGATTTTGCCAATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAAT
GAAGCAGCAGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGCCATGCAGAAGCCTTCCTGTCCT
CGGCTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTTTTTATCACCCTGAGGC
GCAGCAAAAAAGAGCCCTTGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGATGAAGGAGGCGGAGAGGAAGACA

>94194_94194_4_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000506372_length(amino acids)=2095AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEAAAAPSP

--------------------------------------------------------------
>94194_94194_5_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000507958_length(transcript)=7135nt_BP=5227nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGAC
CTTCCCTCAGAGCTGCAGGACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGC
CAAGATGGGAAGTCGCTCCTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAG
GCCGTGCACCATGTCCTGGATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTG
CATCAGAGGCTGCAGCTGTGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAA
CATACAGGTGTGGGGAAATCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACC
AATGCGGATAAATTACTGGAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTG
GAAGACCGGATTCAAGATTTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAG
CTGTGGACGTGGCTGGAGGAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGC
TTTGGCCAGCAGCAGCAGACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCC
ATCTCCAGTAACAAGACCCCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAG
GAGCTCTTCCAGGAGCGCAAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTC
GAGTCTTGGAATGATGAGCTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCA
GACAAAGCCTTGACCATGAACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCT
GGTGTGGAGCTGCTGTGTGATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTG
GATTTAGCCGCAGAGCAGCATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGG
ATCCGCAACGGAGAGTCCATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAG
TTCCAGCATGCCATTGAGAAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATG
GACATGATCCGGGACTGCGCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCC
TCTGTCGCTTTCTACAAAACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGC
GGGGCGGATAAGCTGGGCCCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAG
GCTTGCACCCTTGCTCGGAGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATC
AAAGCTCCTGAACAGCAAGTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGA
CGGCTGGACCAGTGTCAGCAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTT
TCCACACACACCTCCACGGGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACC
AAAGAGAGAGTGAAGCTATTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACT
GCTGTGGATAAGAGGTACAGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCC
AACAAATCGAGTAAAAGTCTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTT
AATGAAGAGAAGCGGAAATCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGG
GAATGTATGGATACGTACCTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGA
AACATGCAAGAAATCTACGAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGT
TTTGTTACTTGGGCAGACAAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGG
TCCTATTTTGACGAGATACAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTAT
CAGCTCCTTTTAAAAGAGCTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAG
CGAGCCAATGATGCCATGCACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTC
CAAGTGTGGGACCCAAAAACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTG
AAAGATTCCAGTGGGAGAAGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCT
TGCAAATTTGCACTGTGGGTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGG
ATAAAGCATATCCGCGAAGTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCC
GCCACAAGACAGAAGGGAAGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCA
CGGACGTCTCAGAACACGCTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGC
AACGAGCTGACCATCCGACGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGAC
CGCTCCCCAGCGGCAGAAGGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAAC
CACAAAGGAGTTATTAGAACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCT
GGGCAAGTTGGAGGGCTTTCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACAC
TATCAGCTATATGTTCCTGAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGAC
ATGACCTACTCCATCATAAATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAG
AAGCCACTGAACTATGAGAAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGT
CCTTTTAAAGATGCTACTATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTC
TACGAAAATGCCAAGATTGGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAAC
TACAATGTTGAAGACGACAGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCA
TGGTACAACATCACAGTCACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAAT
GACAATCCACCCGAACTTGCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACT
GATAAAGATGATTTTGCCAATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAAT
GAAGATAACACAGCCAGCATTCTGACAAGGCGGAGGAGATTTAGTCGAACTGTTCAGGATGTGTATTATCTGCCCATTATGATCTCTGAT
GGTGGAATCCCCTCTCTCAGCAGCAGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGCCATGCA
GAAGCCTTCCTGTCCTCGGCTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTT
TTTATCACCCTGAGGCGCAGCAAAAAAGAGCCCTTGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGATGAAGGA
GGCGGAGAGGAAGACACAGAGGCCTTTGACATCACAGCCTTGAGGAATCCTTCTGCTGCTGAGGAGCTCAAGTACCGGAGGGATATCAGA
CCTGAAGTGAAGCTCACTCCCAGACACCAGACATCATCCACCCTGGAAAGCATAGATGTTCAGGAATTTATTAAGCAAAGACTGGCAGAA
GCAGACCTAGACCCTAGCGTTCCCCCTTATGACTCTCTTCAGACTTATGCCTATGAGGGTCAGAGATCAGAAGCTGGGTCTATCAGCTCG
CTGGATTCAGCAACGACACAATCAGACCAGGATTATCACTACCTTGGAGACTGGGGACCCGAGTTTAAAAAGTTAGCTGAACTCTATGGA
GAAATAGAATCTGAAAGAACAACTTAGGGGGTCAGTTCTTGCAACCTTGTGGAATTTGCTTCCTGAGTAAGTGGATATACAACCTCAGCA
ATGACAAGGAAGAAGTGTGGAAACAGTACTTGGAACTGAGGAAGCTGGACACAGCTCCTGTAGAAACAAGTGCCCTTTTCATGATCGAAA

>94194_94194_5_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000507958_length(amino acids)=2310AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASIL
TRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSK
KEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVP

--------------------------------------------------------------
>94194_94194_6_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000511273_length(transcript)=6524nt_BP=5227nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGAC
CTTCCCTCAGAGCTGCAGGACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGC
CAAGATGGGAAGTCGCTCCTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAG
GCCGTGCACCATGTCCTGGATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTG
CATCAGAGGCTGCAGCTGTGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAA
CATACAGGTGTGGGGAAATCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACC
AATGCGGATAAATTACTGGAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTG
GAAGACCGGATTCAAGATTTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAG
CTGTGGACGTGGCTGGAGGAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGC
TTTGGCCAGCAGCAGCAGACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCC
ATCTCCAGTAACAAGACCCCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAG
GAGCTCTTCCAGGAGCGCAAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTC
GAGTCTTGGAATGATGAGCTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCA
GACAAAGCCTTGACCATGAACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCT
GGTGTGGAGCTGCTGTGTGATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTG
GATTTAGCCGCAGAGCAGCATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGG
ATCCGCAACGGAGAGTCCATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAG
TTCCAGCATGCCATTGAGAAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATG
GACATGATCCGGGACTGCGCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCC
TCTGTCGCTTTCTACAAAACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGC
GGGGCGGATAAGCTGGGCCCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAG
GCTTGCACCCTTGCTCGGAGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATC
AAAGCTCCTGAACAGCAAGTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGA
CGGCTGGACCAGTGTCAGCAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTT
TCCACACACACCTCCACGGGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACC
AAAGAGAGAGTGAAGCTATTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACT
GCTGTGGATAAGAGGTACAGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCC
AACAAATCGAGTAAAAGTCTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTT
AATGAAGAGAAGCGGAAATCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGG
GAATGTATGGATACGTACCTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGA
AACATGCAAGAAATCTACGAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGT
TTTGTTACTTGGGCAGACAAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGG
TCCTATTTTGACGAGATACAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTAT
CAGCTCCTTTTAAAAGAGCTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAG
CGAGCCAATGATGCCATGCACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTC
CAAGTGTGGGACCCAAAAACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTG
AAAGATTCCAGTGGGAGAAGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCT
TGCAAATTTGCACTGTGGGTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGG
ATAAAGCATATCCGCGAAGTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCC
GCCACAAGACAGAAGGGAAGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCA
CGGACGTCTCAGAACACGCTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGC
AACGAGCTGACCATCCGACGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGAC
CGCTCCCCAGCGGCAGAAGGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAAC
CACAAAGGAGTTATTAGAACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCT
GGGCAAGTTGGAGGGCTTTCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACAC
TATCAGCTATATGTTCCTGAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGAC
ATGACCTACTCCATCATAAATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAG
AAGCCACTGAACTATGAGAAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGT
CCTTTTAAAGATGCTACTATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTC
TACGAAAATGCCAAGATTGGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAAC
TACAATGTTGAAGACGACAGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCA
TGGTACAACATCACAGTCACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAAT
GACAATCCACCCGAACTTGCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACT
GATAAAGATGATTTTGCCAATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAAT
GAAGGTGAACATATATACACATATTTGTTTATCTATGTGGTATCTGCTTTGACCTTATATGTAATAGGCTTTATTCTTATATACACACAA
ACATCTTGCAAATCAGCATTCAAAGTCAGTTTGATGCTACTGTGTTATGATCTGTGAATAGCTTGTGTTTAAAATTGAGCCATATGTACA
AATAACTTTCATTGAATTTATTCAGAAGCATCTCTTTAAACAAGAAATGTACATGTAATATGCTCTTGGGCAAATTTTAAGAGAAATCTT

>94194_94194_6_TRIO-CDH18_TRIO_chr5_14420130_ENST00000344204_CDH18_chr5_19612710_ENST00000511273_length(amino acids)=2110AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEGEHIYTY

--------------------------------------------------------------
>94194_94194_7_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000274170_length(transcript)=6939nt_BP=5209nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAG
GACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGCCAAGATGGGAAGTCGCTC
CTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAGGCCGTGCACCATGTCCTG
GATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTGCATCAGAGGCTGCAGCTG
TGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAACATACAGGTGTGGGGAAA
TCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACCAATGCGGATAAATTACTG
GAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTGGAAGACCGGATTCAAGAT
TTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAGCTGTGGACGTGGCTGGAG
GAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGCTTTGGCCAGCAGCAGCAG
ACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCCATCTCCAGTAACAAGACC
CCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAGGAGCTCTTCCAGGAGCGC
AAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTCGAGTCTTGGAATGATGAG
CTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCAGACAAAGCCTTGACCATG
AACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCTGGTGTGGAGCTGCTGTGT
GATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTGGATTTAGCCGCAGAGCAG
CATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGGATCCGCAACGGAGAGTCC
ATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAGTTCCAGCATGCCATTGAG
AAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATGGACATGATCCGGGACTGC
GCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCCTCTGTCGCTTTCTACAAA
ACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGCGGGGCGGATAAGCTGGGC
CCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAGGCTTGCACCCTTGCTCGG
AGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATCAAAGCTCCTGAACAGCAA
GTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGACGGCTGGACCAGTGTCAG
CAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTTTCCACACACACCTCCACG
GGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACCAAAGAGAGAGTGAAGCTA
TTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACTGCTGTGGATAAGAGGTAC
AGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCCAACAAATCGAGTAAAAGT
CTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTTAATGAAGAGAAGCGGAAA
TCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGGGAATGTATGGATACGTAC
CTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGAAACATGCAAGAAATCTAC
GAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGTTTTGTTACTTGGGCAGAC
AAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGGTCCTATTTTGACGAGATA
CAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTATCAGCTCCTTTTAAAAGAG
CTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAGCGAGCCAATGATGCCATG
CACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTCCAAGTGTGGGACCCAAAA
ACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTGAAAGATTCCAGTGGGAGA
AGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCTTGCAAATTTGCACTGTGG
GTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGGATAAAGCATATCCGCGAA
GTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCCGCCACAAGACAGAAGGGA
AGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCACGGACGTCTCAGAACACG
CTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGCAACGAGCTGACCATCCGA
CGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGACCGCTCCCCAGCGGCAGAA
GGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAACCACAAAGGAGTTATTAGA
ACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCTGGGCAAGTTGGAGGGCTT
TCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACACTATCAGCTATATGTTCCT
GAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGACATGACCTACTCCATCATA
AATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAGAAGCCACTGAACTATGAG
AAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGTCCTTTTAAAGATGCTACT
ATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTCTACGAAAATGCCAAGATT
GGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAACTACAATGTTGAAGACGAC
AGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCATGGTACAACATCACAGTC
ACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAATGACAATCCACCCGAACTT
GCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACTGATAAAGATGATTTTGCC
AATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAATGAAGATAACACAGCCAGC
ATTCTGACAAGGCGGAGGAGATTTAGTCGAACTGTTCAGGATGTGTATTATCTGCCCATTATGATCTCTGATGGTGGAATCCCCTCTCTC
AGCAGCAGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGCCATGCAGAAGCCTTCCTGTCCTCG
GCTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTTTTTATCACCCTGAGGCGC
AGCAAAAAAGAGCCCTTGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGATGAAGGAGGCGGAGAGGAAGACACA
GAGGCCTTTGACATCACAGCCTTGAGGAATCCTTCTGCTGCTGAGGAGCTCAAGTACCGGAGGGATATCAGACCTGAAGTGAAGCTCACT
CCCAGACACCAGACATCATCCACCCTGGAAAGCATAGATGTTCAGGAATTTATTAAGCAAAGACTGGCAGAAGCAGACCTAGACCCTAGC
GTTCCCCCTTATGACTCTCTTCAGACTTATGCCTATGAGGGTCAGAGATCAGAAGCTGGGTCTATCAGCTCGCTGGATTCAGCAACGACA
CAATCAGACCAGGATTATCACTACCTTGGAGACTGGGGACCCGAGTTTAAAAAGTTAGCTGAACTCTATGGAGAAATAGAATCTGAAAGA

>94194_94194_7_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000274170_length(amino acids)=2310AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASIL
TRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSK
KEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVP

--------------------------------------------------------------
>94194_94194_8_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000382275_length(transcript)=7133nt_BP=5209nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAG
GACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGCCAAGATGGGAAGTCGCTC
CTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAGGCCGTGCACCATGTCCTG
GATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTGCATCAGAGGCTGCAGCTG
TGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAACATACAGGTGTGGGGAAA
TCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACCAATGCGGATAAATTACTG
GAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTGGAAGACCGGATTCAAGAT
TTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAGCTGTGGACGTGGCTGGAG
GAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGCTTTGGCCAGCAGCAGCAG
ACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCCATCTCCAGTAACAAGACC
CCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAGGAGCTCTTCCAGGAGCGC
AAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTCGAGTCTTGGAATGATGAG
CTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCAGACAAAGCCTTGACCATG
AACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCTGGTGTGGAGCTGCTGTGT
GATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTGGATTTAGCCGCAGAGCAG
CATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGGATCCGCAACGGAGAGTCC
ATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAGTTCCAGCATGCCATTGAG
AAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATGGACATGATCCGGGACTGC
GCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCCTCTGTCGCTTTCTACAAA
ACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGCGGGGCGGATAAGCTGGGC
CCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAGGCTTGCACCCTTGCTCGG
AGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATCAAAGCTCCTGAACAGCAA
GTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGACGGCTGGACCAGTGTCAG
CAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTTTCCACACACACCTCCACG
GGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACCAAAGAGAGAGTGAAGCTA
TTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACTGCTGTGGATAAGAGGTAC
AGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCCAACAAATCGAGTAAAAGT
CTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTTAATGAAGAGAAGCGGAAA
TCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGGGAATGTATGGATACGTAC
CTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGAAACATGCAAGAAATCTAC
GAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGTTTTGTTACTTGGGCAGAC
AAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGGTCCTATTTTGACGAGATA
CAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTATCAGCTCCTTTTAAAAGAG
CTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAGCGAGCCAATGATGCCATG
CACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTCCAAGTGTGGGACCCAAAA
ACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTGAAAGATTCCAGTGGGAGA
AGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCTTGCAAATTTGCACTGTGG
GTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGGATAAAGCATATCCGCGAA
GTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCCGCCACAAGACAGAAGGGA
AGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCACGGACGTCTCAGAACACG
CTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGCAACGAGCTGACCATCCGA
CGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGACCGCTCCCCAGCGGCAGAA
GGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAACCACAAAGGAGTTATTAGA
ACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCTGGGCAAGTTGGAGGGCTT
TCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACACTATCAGCTATATGTTCCT
GAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGACATGACCTACTCCATCATA
AATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAGAAGCCACTGAACTATGAG
AAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGTCCTTTTAAAGATGCTACT
ATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTCTACGAAAATGCCAAGATT
GGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAACTACAATGTTGAAGACGAC
AGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCATGGTACAACATCACAGTC
ACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAATGACAATCCACCCGAACTT
GCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACTGATAAAGATGATTTTGCC
AATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAATGAAGATAACACAGCCAGC
ATTCTGACAAGGCGGAGGAGATTTAGTCGAACTGTTCAGGATGTGTATTATCTGCCCATTATGATCTCTGATGGTGGAATCCCCTCTCTC
AGCAGCAGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGCCATGCAGAAGCCTTCCTGTCCTCG
GCTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTTTTTATCACCCTGAGGCGC
AGCAAAAAAGAGCCCTTGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGATGAAGGAGGCGGAGAGGAAGACACA
GAGGCCTTTGACATCACAGCCTTGAGGAATCCTTCTGCTGCTGAGGAGCTCAAGTACCGGAGGGATATCAGACCTGAAGTGAAGCTCACT
CCCAGACACCAGACATCATCCACCCTGGAAAGCATAGATGTTCAGGAATTTATTAAGCAAAGACTGGCAGAAGCAGACCTAGACCCTAGC
GTTCCCCCTTATGACTCTCTTCAGACTTATGCCTATGAGGGTCAGAGATCAGAAGCTGGGTCTATCAGCTCGCTGGATTCAGCAACGACA
CAATCAGACCAGGATTATCACTACCTTGGAGACTGGGGACCCGAGTTTAAAAAGTTAGCTGAACTCTATGGAGAAATAGAATCTGAAAGA
ACAACTTAGGGGGTCAGTTCTTGCAACCTTGTGGAATTTGCTTCCTGAGTAAGTGGATATACAACCTCAGCAATGACAAGGAAGAAGTGT
GGAAACAGTACTTGGAACTGAGGAAGCTGGACACAGCTCCTGTAGAAACAAGTGCCCTTTTCATGATCGAAACTGGGTTATTTAATTGGA

>94194_94194_8_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000382275_length(amino acids)=2310AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASIL
TRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSK
KEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVP

--------------------------------------------------------------
>94194_94194_9_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000502796_length(transcript)=6477nt_BP=5209nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAG
GACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGCCAAGATGGGAAGTCGCTC
CTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAGGCCGTGCACCATGTCCTG
GATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTGCATCAGAGGCTGCAGCTG
TGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAACATACAGGTGTGGGGAAA
TCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACCAATGCGGATAAATTACTG
GAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTGGAAGACCGGATTCAAGAT
TTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAGCTGTGGACGTGGCTGGAG
GAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGCTTTGGCCAGCAGCAGCAG
ACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCCATCTCCAGTAACAAGACC
CCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAGGAGCTCTTCCAGGAGCGC
AAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTCGAGTCTTGGAATGATGAG
CTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCAGACAAAGCCTTGACCATG
AACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCTGGTGTGGAGCTGCTGTGT
GATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTGGATTTAGCCGCAGAGCAG
CATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGGATCCGCAACGGAGAGTCC
ATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAGTTCCAGCATGCCATTGAG
AAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATGGACATGATCCGGGACTGC
GCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCCTCTGTCGCTTTCTACAAA
ACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGCGGGGCGGATAAGCTGGGC
CCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAGGCTTGCACCCTTGCTCGG
AGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATCAAAGCTCCTGAACAGCAA
GTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGACGGCTGGACCAGTGTCAG
CAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTTTCCACACACACCTCCACG
GGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACCAAAGAGAGAGTGAAGCTA
TTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACTGCTGTGGATAAGAGGTAC
AGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCCAACAAATCGAGTAAAAGT
CTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTTAATGAAGAGAAGCGGAAA
TCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGGGAATGTATGGATACGTAC
CTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGAAACATGCAAGAAATCTAC
GAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGTTTTGTTACTTGGGCAGAC
AAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGGTCCTATTTTGACGAGATA
CAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTATCAGCTCCTTTTAAAAGAG
CTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAGCGAGCCAATGATGCCATG
CACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTCCAAGTGTGGGACCCAAAA
ACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTGAAAGATTCCAGTGGGAGA
AGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCTTGCAAATTTGCACTGTGG
GTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGGATAAAGCATATCCGCGAA
GTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCCGCCACAAGACAGAAGGGA
AGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCACGGACGTCTCAGAACACG
CTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGCAACGAGCTGACCATCCGA
CGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGACCGCTCCCCAGCGGCAGAA
GGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAACCACAAAGGAGTTATTAGA
ACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCTGGGCAAGTTGGAGGGCTT
TCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACACTATCAGCTATATGTTCCT
GAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGACATGACCTACTCCATCATA
AATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAGAAGCCACTGAACTATGAG
AAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGTCCTTTTAAAGATGCTACT
ATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTCTACGAAAATGCCAAGATT
GGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAACTACAATGTTGAAGACGAC
AGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCATGGTACAACATCACAGTC
ACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAATGACAATCCACCCGAACTT
GCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACTGATAAAGATGATTTTGCC
AATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAATGAAGCAGCAGCACCCTCA
CCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGCCATGCAGAAGCCTTCCTGTCCTCGGCTGGTTTGAGTACAGGAG
CCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTTTTTATCACCCTGAGGCGCAGCAAAAAAGAGCCCTTGA

>94194_94194_9_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000502796_length(amino acids)=2094AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEAAAPSPS

--------------------------------------------------------------
>94194_94194_10_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000506372_length(transcript)=6486nt_BP=5209nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAG
GACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGCCAAGATGGGAAGTCGCTC
CTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAGGCCGTGCACCATGTCCTG
GATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTGCATCAGAGGCTGCAGCTG
TGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAACATACAGGTGTGGGGAAA
TCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACCAATGCGGATAAATTACTG
GAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTGGAAGACCGGATTCAAGAT
TTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAGCTGTGGACGTGGCTGGAG
GAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGCTTTGGCCAGCAGCAGCAG
ACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCCATCTCCAGTAACAAGACC
CCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAGGAGCTCTTCCAGGAGCGC
AAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTCGAGTCTTGGAATGATGAG
CTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCAGACAAAGCCTTGACCATG
AACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCTGGTGTGGAGCTGCTGTGT
GATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTGGATTTAGCCGCAGAGCAG
CATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGGATCCGCAACGGAGAGTCC
ATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAGTTCCAGCATGCCATTGAG
AAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATGGACATGATCCGGGACTGC
GCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCCTCTGTCGCTTTCTACAAA
ACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGCGGGGCGGATAAGCTGGGC
CCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAGGCTTGCACCCTTGCTCGG
AGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATCAAAGCTCCTGAACAGCAA
GTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGACGGCTGGACCAGTGTCAG
CAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTTTCCACACACACCTCCACG
GGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACCAAAGAGAGAGTGAAGCTA
TTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACTGCTGTGGATAAGAGGTAC
AGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCCAACAAATCGAGTAAAAGT
CTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTTAATGAAGAGAAGCGGAAA
TCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGGGAATGTATGGATACGTAC
CTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGAAACATGCAAGAAATCTAC
GAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGTTTTGTTACTTGGGCAGAC
AAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGGTCCTATTTTGACGAGATA
CAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTATCAGCTCCTTTTAAAAGAG
CTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAGCGAGCCAATGATGCCATG
CACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTCCAAGTGTGGGACCCAAAA
ACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTGAAAGATTCCAGTGGGAGA
AGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCTTGCAAATTTGCACTGTGG
GTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGGATAAAGCATATCCGCGAA
GTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCCGCCACAAGACAGAAGGGA
AGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCACGGACGTCTCAGAACACG
CTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGCAACGAGCTGACCATCCGA
CGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGACCGCTCCCCAGCGGCAGAA
GGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAACCACAAAGGAGTTATTAGA
ACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCTGGGCAAGTTGGAGGGCTT
TCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACACTATCAGCTATATGTTCCT
GAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGACATGACCTACTCCATCATA
AATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAGAAGCCACTGAACTATGAG
AAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGTCCTTTTAAAGATGCTACT
ATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTCTACGAAAATGCCAAGATT
GGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAACTACAATGTTGAAGACGAC
AGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCATGGTACAACATCACAGTC
ACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAATGACAATCCACCCGAACTT
GCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACTGATAAAGATGATTTTGCC
AATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAATGAAGCAGCAGCAGCACCC
TCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGCCATGCAGAAGCCTTCCTGTCCTCGGCTGGTTTGAGTACAG
GAGCCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTTTTTATCACCCTGAGGCGCAGCAAAAAAGAGCCCT
TGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGATGAAGGAGGCGGAGAGGAAGACACAGAGGCCTTTGACATCA

>94194_94194_10_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000506372_length(amino acids)=2095AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEAAAAPSP

--------------------------------------------------------------
>94194_94194_11_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000507958_length(transcript)=7117nt_BP=5209nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAG
GACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGCCAAGATGGGAAGTCGCTC
CTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAGGCCGTGCACCATGTCCTG
GATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTGCATCAGAGGCTGCAGCTG
TGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAACATACAGGTGTGGGGAAA
TCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACCAATGCGGATAAATTACTG
GAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTGGAAGACCGGATTCAAGAT
TTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAGCTGTGGACGTGGCTGGAG
GAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGCTTTGGCCAGCAGCAGCAG
ACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCCATCTCCAGTAACAAGACC
CCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAGGAGCTCTTCCAGGAGCGC
AAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTCGAGTCTTGGAATGATGAG
CTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCAGACAAAGCCTTGACCATG
AACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCTGGTGTGGAGCTGCTGTGT
GATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTGGATTTAGCCGCAGAGCAG
CATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGGATCCGCAACGGAGAGTCC
ATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAGTTCCAGCATGCCATTGAG
AAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATGGACATGATCCGGGACTGC
GCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCCTCTGTCGCTTTCTACAAA
ACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGCGGGGCGGATAAGCTGGGC
CCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAGGCTTGCACCCTTGCTCGG
AGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATCAAAGCTCCTGAACAGCAA
GTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGACGGCTGGACCAGTGTCAG
CAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTTTCCACACACACCTCCACG
GGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACCAAAGAGAGAGTGAAGCTA
TTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACTGCTGTGGATAAGAGGTAC
AGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCCAACAAATCGAGTAAAAGT
CTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTTAATGAAGAGAAGCGGAAA
TCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGGGAATGTATGGATACGTAC
CTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGAAACATGCAAGAAATCTAC
GAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGTTTTGTTACTTGGGCAGAC
AAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGGTCCTATTTTGACGAGATA
CAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTATCAGCTCCTTTTAAAAGAG
CTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAGCGAGCCAATGATGCCATG
CACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTCCAAGTGTGGGACCCAAAA
ACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTGAAAGATTCCAGTGGGAGA
AGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCTTGCAAATTTGCACTGTGG
GTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGGATAAAGCATATCCGCGAA
GTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCCGCCACAAGACAGAAGGGA
AGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCACGGACGTCTCAGAACACG
CTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGCAACGAGCTGACCATCCGA
CGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGACCGCTCCCCAGCGGCAGAA
GGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAACCACAAAGGAGTTATTAGA
ACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCTGGGCAAGTTGGAGGGCTT
TCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACACTATCAGCTATATGTTCCT
GAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGACATGACCTACTCCATCATA
AATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAGAAGCCACTGAACTATGAG
AAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGTCCTTTTAAAGATGCTACT
ATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTCTACGAAAATGCCAAGATT
GGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAACTACAATGTTGAAGACGAC
AGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCATGGTACAACATCACAGTC
ACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAATGACAATCCACCCGAACTT
GCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACTGATAAAGATGATTTTGCC
AATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAATGAAGATAACACAGCCAGC
ATTCTGACAAGGCGGAGGAGATTTAGTCGAACTGTTCAGGATGTGTATTATCTGCCCATTATGATCTCTGATGGTGGAATCCCCTCTCTC
AGCAGCAGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGCCATGCAGAAGCCTTCCTGTCCTCG
GCTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTTTTTATCACCCTGAGGCGC
AGCAAAAAAGAGCCCTTGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGATGAAGGAGGCGGAGAGGAAGACACA
GAGGCCTTTGACATCACAGCCTTGAGGAATCCTTCTGCTGCTGAGGAGCTCAAGTACCGGAGGGATATCAGACCTGAAGTGAAGCTCACT
CCCAGACACCAGACATCATCCACCCTGGAAAGCATAGATGTTCAGGAATTTATTAAGCAAAGACTGGCAGAAGCAGACCTAGACCCTAGC
GTTCCCCCTTATGACTCTCTTCAGACTTATGCCTATGAGGGTCAGAGATCAGAAGCTGGGTCTATCAGCTCGCTGGATTCAGCAACGACA
CAATCAGACCAGGATTATCACTACCTTGGAGACTGGGGACCCGAGTTTAAAAAGTTAGCTGAACTCTATGGAGAAATAGAATCTGAAAGA
ACAACTTAGGGGGTCAGTTCTTGCAACCTTGTGGAATTTGCTTCCTGAGTAAGTGGATATACAACCTCAGCAATGACAAGGAAGAAGTGT
GGAAACAGTACTTGGAACTGAGGAAGCTGGACACAGCTCCTGTAGAAACAAGTGCCCTTTTCATGATCGAAACTGGGTTATTTAATTGGA

>94194_94194_11_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000507958_length(amino acids)=2310AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASIL
TRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSK
KEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVP

--------------------------------------------------------------
>94194_94194_12_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000511273_length(transcript)=6506nt_BP=5209nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAG
GACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGCCAAGATGGGAAGTCGCTC
CTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAGGCCGTGCACCATGTCCTG
GATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTGCATCAGAGGCTGCAGCTG
TGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAACATACAGGTGTGGGGAAA
TCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACCAATGCGGATAAATTACTG
GAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTGGAAGACCGGATTCAAGAT
TTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAGCTGTGGACGTGGCTGGAG
GAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGCTTTGGCCAGCAGCAGCAG
ACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCCATCTCCAGTAACAAGACC
CCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAGGAGCTCTTCCAGGAGCGC
AAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTCGAGTCTTGGAATGATGAG
CTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCAGACAAAGCCTTGACCATG
AACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCTGGTGTGGAGCTGCTGTGT
GATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTGGATTTAGCCGCAGAGCAG
CATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGGATCCGCAACGGAGAGTCC
ATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAGTTCCAGCATGCCATTGAG
AAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATGGACATGATCCGGGACTGC
GCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCCTCTGTCGCTTTCTACAAA
ACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGCGGGGCGGATAAGCTGGGC
CCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAGGCTTGCACCCTTGCTCGG
AGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATCAAAGCTCCTGAACAGCAA
GTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGACGGCTGGACCAGTGTCAG
CAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTTTCCACACACACCTCCACG
GGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACCAAAGAGAGAGTGAAGCTA
TTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACTGCTGTGGATAAGAGGTAC
AGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCCAACAAATCGAGTAAAAGT
CTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTTAATGAAGAGAAGCGGAAA
TCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGGGAATGTATGGATACGTAC
CTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGAAACATGCAAGAAATCTAC
GAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGTTTTGTTACTTGGGCAGAC
AAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGGTCCTATTTTGACGAGATA
CAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTATCAGCTCCTTTTAAAAGAG
CTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAGCGAGCCAATGATGCCATG
CACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTCCAAGTGTGGGACCCAAAA
ACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTGAAAGATTCCAGTGGGAGA
AGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCTTGCAAATTTGCACTGTGG
GTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGGATAAAGCATATCCGCGAA
GTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCCGCCACAAGACAGAAGGGA
AGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCACGGACGTCTCAGAACACG
CTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGCAACGAGCTGACCATCCGA
CGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGACCGCTCCCCAGCGGCAGAA
GGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAACCACAAAGGAGTTATTAGA
ACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCTGGGCAAGTTGGAGGGCTT
TCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAAACACTATCAGCTATATGTTCCT
GAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAATGCTGACATGACCTACTCCATCATA
AATGGTGATGGCATGGGAATATTCTCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAGAAGCCACTGAACTATGAG
AAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCACTTGGGTCCTTTTAAAGATGCTACT
ATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTATTTTCCATGCCTTCCTACCTCATGGAAGTCTACGAAAATGCCAAGATT
GGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTCATCAACTACAATGTTGAAGACGAC
AGATTTTTCAACATTGATGCCAATACTGGGACCATTAGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCATGGTACAACATCACAGTC
ACTGCTTCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAATGACAATCCACCCGAACTT
GCCAGGGAATATGATATTATTGTATGTGAAAATTCTAAGCCTGGCCAGGTTATTCATACCATCAGTGCCACTGATAAAGATGATTTTGCC
AATGGACCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAATGAAGGTGAACATATATAC
ACATATTTGTTTATCTATGTGGTATCTGCTTTGACCTTATATGTAATAGGCTTTATTCTTATATACACACAAACATCTTGCAAATCAGCA
TTCAAAGTCAGTTTGATGCTACTGTGTTATGATCTGTGAATAGCTTGTGTTTAAAATTGAGCCATATGTACAAATAACTTTCATTGAATT
TATTCAGAAGCATCTCTTTAAACAAGAAATGTACATGTAATATGCTCTTGGGCAAATTTTAAGAGAAATCTTAGCTGACAAACTTGTTTA

>94194_94194_12_TRIO-CDH18_TRIO_chr5_14420130_ENST00000537187_CDH18_chr5_19612710_ENST00000511273_length(amino acids)=2110AA_BP=1729
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPES
AQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML
KIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTA
SEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEGEHIYTY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRIO-CDH18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIO-CDH18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIO-CDH18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource