FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TRIO-IPO11 (FusionGDB2 ID:94205)

Fusion Gene Summary for TRIO-IPO11

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO-IPO11
Fusion gene ID: 94205
HgeneTgene
Gene symbol

TRIO

IPO11

Gene ID

7204

51194

Gene nametrio Rho guanine nucleotide exchange factorimportin 11
SynonymsARHGEF23|MEBAS|MRD44|tgatRanBP11
Cytomap

5p15.2

5q12.1

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)importin-11Ran binding protein 11imp11ran-binding protein 11
Modification date2020031320200313
UniProtAcc

TRIOBP

Q9UI26

Ensembl transtripts involved in fusion geneENST00000344204, ENST00000537187, 
ENST00000344135, ENST00000509967, 
ENST00000515710, 		ENST00000409534, 
ENST00000512177, ENST00000325324, 
ENST00000409296, 
Fusion gene scores* DoF score34 X 28 X 12=114246 X 6 X 7=252
# samples 357
** MAII scorelog2(35/11424*10)=-5.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIO [Title/Abstract] AND IPO11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIO(14477072)-IPO11(61846194), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRIO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IPO11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-HU-A4GP-11ATRIOchr5

14477072

+IPO11chr5

61846194

+


Top

Fusion Gene ORF analysis for TRIO-IPO11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344204ENST00000409534TRIOchr5

14477072

+IPO11chr5

61846194

+
5CDS-intronENST00000344204ENST00000512177TRIOchr5

14477072

+IPO11chr5

61846194

+
5CDS-intronENST00000537187ENST00000409534TRIOchr5

14477072

+IPO11chr5

61846194

+
5CDS-intronENST00000537187ENST00000512177TRIOchr5

14477072

+IPO11chr5

61846194

+
In-frameENST00000344204ENST00000325324TRIOchr5

14477072

+IPO11chr5

61846194

+
In-frameENST00000344204ENST00000409296TRIOchr5

14477072

+IPO11chr5

61846194

+
In-frameENST00000537187ENST00000325324TRIOchr5

14477072

+IPO11chr5

61846194

+
In-frameENST00000537187ENST00000409296TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-3CDSENST00000344135ENST00000325324TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-3CDSENST00000344135ENST00000409296TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-3CDSENST00000509967ENST00000325324TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-3CDSENST00000509967ENST00000409296TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-3CDSENST00000515710ENST00000325324TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-3CDSENST00000515710ENST00000409296TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-intronENST00000344135ENST00000409534TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-intronENST00000344135ENST00000512177TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-intronENST00000509967ENST00000409534TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-intronENST00000509967ENST00000512177TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-intronENST00000515710ENST00000409534TRIOchr5

14477072

+IPO11chr5

61846194

+
intron-intronENST00000515710ENST00000512177TRIOchr5

14477072

+IPO11chr5

61846194

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344204TRIOchr514477072+ENST00000325324IPO11chr561846194+811461772468542276
ENST00000344204TRIOchr514477072+ENST00000409296IPO11chr561846194+724161772468542276
ENST00000537187TRIOchr514477072+ENST00000325324IPO11chr561846194+80966159668362276
ENST00000537187TRIOchr514477072+ENST00000409296IPO11chr561846194+72236159668362276

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344204ENST00000325324TRIOchr514477072+IPO11chr561846194+0.0020742980.99792564
ENST00000344204ENST00000409296TRIOchr514477072+IPO11chr561846194+0.0043792510.9956208
ENST00000537187ENST00000325324TRIOchr514477072+IPO11chr561846194+0.0020330670.99796695
ENST00000537187ENST00000409296TRIOchr514477072+IPO11chr561846194+0.0043253310.99567467

Top

Fusion Genomic Features for TRIO-IPO11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRIOchr514477072+IPO11chr561846193+0.0501801670.9498198
TRIOchr514477072+IPO11chr561846193+0.0501801670.9498198

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for TRIO-IPO11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:14477072/chr5:61846194)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

TRIOBP

IPO11

Q9UI26

2365FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11032817}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41571845_185020513098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+4157715_71820513098.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41581845_185020512922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+4158715_71820512922.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41571292_146720513098.0DomainDH 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41571480_159120513098.0DomainPH 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41571656_172120513098.0DomainSH3 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+415765_21020513098.0DomainCRAL-TRIO
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41581292_146720512922.0DomainDH 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41581480_159120512922.0DomainPH 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41581656_172120512922.0DomainSH3 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+415865_21020512922.0DomainCRAL-TRIO
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41571109_121620513098.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+4157311_41820513098.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+4157538_64420513098.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+4157878_98420513098.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41581109_121620512922.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+4158311_41820512922.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+4158538_64420512922.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+4158878_98420512922.0RepeatNote=Spectrin 3
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330765_804750976.0RepeatNote=HEAT 12
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330819_849750976.0RepeatNote=HEAT 13
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330850_887750976.0RepeatNote=HEAT 14
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330957_974750976.0RepeatNote=HEAT 15
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330819_8497901016.0RepeatNote=HEAT 13
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330850_8877901016.0RepeatNote=HEAT 14
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330957_9747901016.0RepeatNote=HEAT 15

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1101845_18500597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1102292_23120597.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1102545_25510597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+110715_7180597.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41572292_231220513098.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41572545_255120513098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41582292_231220512922.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41582545_255120512922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1101292_14670597.0DomainDH 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1101480_15910597.0DomainPH 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1101656_17210597.0DomainSH3 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1101969_21450597.0DomainDH 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1102157_22710597.0DomainPH 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1102551_26160597.0DomainSH3 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1102685_27750597.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1102796_30520597.0DomainProtein kinase
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+11065_2100597.0DomainCRAL-TRIO
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41571969_214520513098.0DomainDH 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41572157_227120513098.0DomainPH 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41572551_261620513098.0DomainSH3 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41572685_277520513098.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41572796_305220513098.0DomainProtein kinase
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41581969_214520512922.0DomainDH 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41582157_227120512922.0DomainPH 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41582551_261620512922.0DomainSH3 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41582685_277520512922.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41582796_305220512922.0DomainProtein kinase
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1102802_28100597.0Nucleotide bindingATP
HgeneTRIOchr5:14477072chr5:61846194ENST00000344204+41572802_281020513098.0Nucleotide bindingATP
HgeneTRIOchr5:14477072chr5:61846194ENST00000537187+41582802_281020512922.0Nucleotide bindingATP
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+1101109_12160597.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+110311_4180597.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+110538_6440597.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14477072chr5:61846194ENST00000344135+110878_9840597.0RepeatNote=Spectrin 3
TgeneIPO11chr5:14477072chr5:61846194ENST00000325324233028_100750976.0DomainImportin N-terminal
TgeneIPO11chr5:14477072chr5:61846194ENST00000409296233028_1007901016.0DomainImportin N-terminal
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330123_160750976.0RepeatNote=HEAT 1
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330209_248750976.0RepeatNote=HEAT 2
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330318_356750976.0RepeatNote=HEAT 3
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330422_459750976.0RepeatNote=HEAT 4
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330473_509750976.0RepeatNote=HEAT 5
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330511_548750976.0RepeatNote=HEAT 6
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330555_593750976.0RepeatNote=HEAT 7
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330600_636750976.0RepeatNote=HEAT 8
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330640_677750976.0RepeatNote=HEAT 9
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330683_720750976.0RepeatNote=HEAT 10
TgeneIPO11chr5:14477072chr5:61846194ENST000003253242330743_764750976.0RepeatNote=HEAT 11
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330123_1607901016.0RepeatNote=HEAT 1
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330209_2487901016.0RepeatNote=HEAT 2
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330318_3567901016.0RepeatNote=HEAT 3
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330422_4597901016.0RepeatNote=HEAT 4
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330473_5097901016.0RepeatNote=HEAT 5
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330511_5487901016.0RepeatNote=HEAT 6
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330555_5937901016.0RepeatNote=HEAT 7
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330600_6367901016.0RepeatNote=HEAT 8
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330640_6777901016.0RepeatNote=HEAT 9
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330683_7207901016.0RepeatNote=HEAT 10
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330743_7647901016.0RepeatNote=HEAT 11
TgeneIPO11chr5:14477072chr5:61846194ENST000004092962330765_8047901016.0RepeatNote=HEAT 12


Top

Fusion Gene Sequence for TRIO-IPO11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94205_94205_1_TRIO-IPO11_TRIO_chr5_14477072_ENST00000344204_IPO11_chr5_61846194_ENST00000325324_length(transcript)=8114nt_BP=6177nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGAC
CTTCCCTCAGAGCTGCAGGACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGC
CAAGATGGGAAGTCGCTCCTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAG
GCCGTGCACCATGTCCTGGATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTG
CATCAGAGGCTGCAGCTGTGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAA
CATACAGGTGTGGGGAAATCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACC
AATGCGGATAAATTACTGGAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTG
GAAGACCGGATTCAAGATTTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAG
CTGTGGACGTGGCTGGAGGAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGC
TTTGGCCAGCAGCAGCAGACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCC
ATCTCCAGTAACAAGACCCCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAG
GAGCTCTTCCAGGAGCGCAAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTC
GAGTCTTGGAATGATGAGCTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCA
GACAAAGCCTTGACCATGAACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCT
GGTGTGGAGCTGCTGTGTGATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTG
GATTTAGCCGCAGAGCAGCATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGG
ATCCGCAACGGAGAGTCCATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAG
TTCCAGCATGCCATTGAGAAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATG
GACATGATCCGGGACTGCGCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCC
TCTGTCGCTTTCTACAAAACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGC
GGGGCGGATAAGCTGGGCCCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAG
GCTTGCACCCTTGCTCGGAGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATC
AAAGCTCCTGAACAGCAAGTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGA
CGGCTGGACCAGTGTCAGCAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTT
TCCACACACACCTCCACGGGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACC
AAAGAGAGAGTGAAGCTATTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACT
GCTGTGGATAAGAGGTACAGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCC
AACAAATCGAGTAAAAGTCTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTT
AATGAAGAGAAGCGGAAATCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGG
GAATGTATGGATACGTACCTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGA
AACATGCAAGAAATCTACGAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGT
TTTGTTACTTGGGCAGACAAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGG
TCCTATTTTGACGAGATACAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTAT
CAGCTCCTTTTAAAAGAGCTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAG
CGAGCCAATGATGCCATGCACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTC
CAAGTGTGGGACCCAAAAACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTG
AAAGATTCCAGTGGGAGAAGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCT
TGCAAATTTGCACTGTGGGTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGG
ATAAAGCATATCCGCGAAGTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCC
GCCACAAGACAGAAGGGAAGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCA
CGGACGTCTCAGAACACGCTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGC
AACGAGCTGACCATCCGACGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGAC
CGCTCCCCAGCGGCAGAAGGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAAC
CACAAAGACTCGCTCTCCGTCTCCAGCAATGACGCCAGTCCACCCGCATCCGTGGCTTCCCTCCAGCCCCACATGATCGGGGCCCAGAGC
TCGCCGGGCCCCAAGCGGCCGGGCAACACCCTGCGCAAGTGGCTCACCAGCCCCGTGCGGCGGCTCAGCAGCGGCAAGGCCGACGGGCAC
GTGAAGAAGCTGGCGCACAAGCACAAGAAGAGCCGCGAGGTCCGCAAGAGCGCCGACGCCGGCTCGCAGAAGGACTCCGACGACAGTGCG
GCCACCCCGCAGGACGAGACGGTCGAGGAGAGAGGCCGGAACGAGGGCCTGAGCAGCGGTACTCTCTCCAAATCCTCCTCCTCGGGGATG
CAGAGCTGTGGAGAAGAGGAAGGCGAGGAGGGGGCCGACGCCGTGCCCCTGCCGCCACCCATGGCCATCCAGCAGCACAGCCTCCTCCAG
CCAGACTCACAGGATGACAAGGCCTCTTCTCGGTTATTAGTCCGCCCCACCAGCTCCGAAACACCGAGTGCAGCCGAGCTCGTCAGTGCA
ATTGAGGAACTCGTGAAAAGCAAGATGGCACTGGAGGATCGCCCCAGCTCACTCCTTGTTGACCAGGGAGATAGTAGCAGCCCTTCCTTC
AACCCTTCGGATAATTCCCTTCTCTCTTCCTCCTCGCCCATTGATGAGATGGAAGAAAGGAAATCCAGCTCTTTAAAGAGAAGACACTAC
GTTTTGCAAGAACTAGTGGAGACAGAGCGTGACTATGTGCGGGACCTTGGCTATGTGGTTGAGGGCTACATGGCACTTATGAAAGAAGAT
GGTGTTCCTGATGACATGAAAGGAAAAGACAAAATTGTGTTCGGCAACATCCATCAGATTTACGACTGGCACAGAGACTTTTTTTTAGGA
GAGTTAGAGAAGTGCCTTGAAGATCCAGAAAAACTAGGATCCCTTTTTGTTAAACACGTTGTGGAAAATGCCCTTAAAGTGAACCCAATA
CTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCACGTAT
CTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAGATG
GACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTTTGGCT
TTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGATGTC
ATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAGAACCA
CCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAGCTC
AAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGGAGTTT
TTGCAAGGATTCTAAGAGCACATGACATGTGGCTGCCTCCCCTTTCAGAAACAAGCTGAGTAACCCAGCCTGCCGTTTGTATGTGAGAGC
CTGCTGAGATGAAGAAATCACTTCATGAAAATAAGCAAAGACCACACATTTTTTACTACAAAATGTAAAGGATAAATGTAAATCCTGCAT
AACTAAAATCACAAACCTATTCCTCAAAAGAATTTAATTTTATATTTATGAGGGGGCCCTTCACTAAAAAGTACATGTAAAAGTACATTT
GATGACAATAGCTGCTTAGTTTCCTGTTAAGAGAAGAAACTTTATCTTTTAATTATGTGCTCTTAATATTTGAAGATGAGAGTTAATACC
TGAGATGTTTTTCTGCAACCAAAATTCATTAAATTTGGCTGCCTTATCCTTTTTTTAAGCTAATGAAACTACAGGTTTGAAAAATGACAA
AGCTGTTCAGATGATGCTATTAAAGAAATGTGTGTACTAAGCAAAAATATATAAATAGTGACAAATACACATTACCAAGCTTATCTTGCA
AGGGAGTTATTTTCATCTAACATAGAAAGTGTGTTTTATCAGACAAATGCTTTTATTTTCATTCTAATAATTTGATACAGAAATTAGTAA
AGGCATTTTTTTCTTTTTTTTTCCAGTAAATACATTGGGTCTATAAATGTGCATTTGTAAGGGCCACAAAAGTGAACGTGTGGTACTGTA
GTACCACGTGGGAGACCTCTGGTTATGGTTTAGTCCTAGTTCCTTTGTTACTCCTGTGAGCACCGAGAAGAACTGGGCGACTCCCAGTCC
CACCTGTGCTGTGACAGTCCCACGTGGCTATGACAGACTGTTTAGTACTTACCCTTCTCAGGTTCCTCAGTGCAGGGGTGCATCAGGGCC
TCAATAATAGGGGTATACCTGGGAGGATCCAGCAGTAATCCCCAGGGTACTAGGATTACTAGTACTCTGATGGAACTAGTCTTCCTTCCT
TATTCCTCGAACATGCAGTACATAAAAAGGGGAAAAGGAGAAAAAAAAAGCCTTACTTTGTTTTACTTGCCATTTATTGTAAGGAAACTT
TAAAGCATTTTTTAGGAAATACTCAAAAGCAAGGTTGGAAAATGTTTTATCTTTCTATAGAAAGTTGGGTACAGTATGTAACTGCGGGAA
ACCCACTGCCCCTTTGTAAGCTGTGGAACCCAAACTGTATGGGGATATTTGATGTTTTCAGAAAGAGGAAGAAAATATGGTCCAAATTAA

>94205_94205_1_TRIO-IPO11_TRIO_chr5_14477072_ENST00000344204_IPO11_chr5_61846194_ENST00000325324_length(amino acids)=2276AA_BP=2051
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH
KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQPDSQDDKA
SSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET
ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHVVENALKVNPILGPQMFQP
ILPYVFKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSD
NSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEMLG

--------------------------------------------------------------
>94205_94205_2_TRIO-IPO11_TRIO_chr5_14477072_ENST00000344204_IPO11_chr5_61846194_ENST00000409296_length(transcript)=7241nt_BP=6177nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGAC
CTTCCCTCAGAGCTGCAGGACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGC
CAAGATGGGAAGTCGCTCCTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAG
GCCGTGCACCATGTCCTGGATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTG
CATCAGAGGCTGCAGCTGTGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAA
CATACAGGTGTGGGGAAATCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACC
AATGCGGATAAATTACTGGAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTG
GAAGACCGGATTCAAGATTTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAG
CTGTGGACGTGGCTGGAGGAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGC
TTTGGCCAGCAGCAGCAGACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCC
ATCTCCAGTAACAAGACCCCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAG
GAGCTCTTCCAGGAGCGCAAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTC
GAGTCTTGGAATGATGAGCTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCA
GACAAAGCCTTGACCATGAACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCT
GGTGTGGAGCTGCTGTGTGATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTG
GATTTAGCCGCAGAGCAGCATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGG
ATCCGCAACGGAGAGTCCATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAG
TTCCAGCATGCCATTGAGAAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATG
GACATGATCCGGGACTGCGCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCC
TCTGTCGCTTTCTACAAAACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGC
GGGGCGGATAAGCTGGGCCCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAG
GCTTGCACCCTTGCTCGGAGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATC
AAAGCTCCTGAACAGCAAGTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGA
CGGCTGGACCAGTGTCAGCAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTT
TCCACACACACCTCCACGGGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACC
AAAGAGAGAGTGAAGCTATTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACT
GCTGTGGATAAGAGGTACAGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCC
AACAAATCGAGTAAAAGTCTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTT
AATGAAGAGAAGCGGAAATCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGG
GAATGTATGGATACGTACCTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGA
AACATGCAAGAAATCTACGAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGT
TTTGTTACTTGGGCAGACAAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGG
TCCTATTTTGACGAGATACAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTAT
CAGCTCCTTTTAAAAGAGCTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAG
CGAGCCAATGATGCCATGCACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTC
CAAGTGTGGGACCCAAAAACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTG
AAAGATTCCAGTGGGAGAAGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCT
TGCAAATTTGCACTGTGGGTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGG
ATAAAGCATATCCGCGAAGTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCC
GCCACAAGACAGAAGGGAAGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCA
CGGACGTCTCAGAACACGCTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGC
AACGAGCTGACCATCCGACGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGAC
CGCTCCCCAGCGGCAGAAGGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAAC
CACAAAGACTCGCTCTCCGTCTCCAGCAATGACGCCAGTCCACCCGCATCCGTGGCTTCCCTCCAGCCCCACATGATCGGGGCCCAGAGC
TCGCCGGGCCCCAAGCGGCCGGGCAACACCCTGCGCAAGTGGCTCACCAGCCCCGTGCGGCGGCTCAGCAGCGGCAAGGCCGACGGGCAC
GTGAAGAAGCTGGCGCACAAGCACAAGAAGAGCCGCGAGGTCCGCAAGAGCGCCGACGCCGGCTCGCAGAAGGACTCCGACGACAGTGCG
GCCACCCCGCAGGACGAGACGGTCGAGGAGAGAGGCCGGAACGAGGGCCTGAGCAGCGGTACTCTCTCCAAATCCTCCTCCTCGGGGATG
CAGAGCTGTGGAGAAGAGGAAGGCGAGGAGGGGGCCGACGCCGTGCCCCTGCCGCCACCCATGGCCATCCAGCAGCACAGCCTCCTCCAG
CCAGACTCACAGGATGACAAGGCCTCTTCTCGGTTATTAGTCCGCCCCACCAGCTCCGAAACACCGAGTGCAGCCGAGCTCGTCAGTGCA
ATTGAGGAACTCGTGAAAAGCAAGATGGCACTGGAGGATCGCCCCAGCTCACTCCTTGTTGACCAGGGAGATAGTAGCAGCCCTTCCTTC
AACCCTTCGGATAATTCCCTTCTCTCTTCCTCCTCGCCCATTGATGAGATGGAAGAAAGGAAATCCAGCTCTTTAAAGAGAAGACACTAC
GTTTTGCAAGAACTAGTGGAGACAGAGCGTGACTATGTGCGGGACCTTGGCTATGTGGTTGAGGGCTACATGGCACTTATGAAAGAAGAT
GGTGTTCCTGATGACATGAAAGGAAAAGACAAAATTGTGTTCGGCAACATCCATCAGATTTACGACTGGCACAGAGACTTTTTTTTAGGA
GAGTTAGAGAAGTGCCTTGAAGATCCAGAAAAACTAGGATCCCTTTTTGTTAAACACGTTGTGGAAAATGCCCTTAAAGTGAACCCAATA
CTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCACGTAT
CTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAGATG
GACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTTTGGCT
TTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGATGTC
ATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAGAACCA
CCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAGCTC
AAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGGAGTTT
TTGCAAGGATTCTAAGAGCACATGACATGTGGCTGCCTCCCCTTTCAGAAACAAGCTGAGTAACCCAGCCTGCCGTTTGTATGTGAGAGC
CTGCTGAGATGAAGAAATCACTTCATGAAAATAAGCAAAGACCACACATTTTTTACTACAAAATGTAAAGGATAAATGTAAATCCTGCAT
AACTAAAATCACAAACCTATTCCTCAAAAGAATTTAATTTTATATTTATGAGGGGGCCCTTCACTAAAAAGTACATGTAAAAGTACATTT
GATGACAATAGCTGCTTAGTTTCCTGTTAAGAGAAGAAACTTTATCTTTTAATTATGTGCTCTTAATATTTGAAGATGAGAGTTAATACC

>94205_94205_2_TRIO-IPO11_TRIO_chr5_14477072_ENST00000344204_IPO11_chr5_61846194_ENST00000409296_length(amino acids)=2276AA_BP=2051
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH
KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQPDSQDDKA
SSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET
ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHVVENALKVNPILGPQMFQP
ILPYVFKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSD
NSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEMLG

--------------------------------------------------------------
>94205_94205_3_TRIO-IPO11_TRIO_chr5_14477072_ENST00000537187_IPO11_chr5_61846194_ENST00000325324_length(transcript)=8096nt_BP=6159nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAG
GACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGCCAAGATGGGAAGTCGCTC
CTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAGGCCGTGCACCATGTCCTG
GATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTGCATCAGAGGCTGCAGCTG
TGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAACATACAGGTGTGGGGAAA
TCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACCAATGCGGATAAATTACTG
GAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTGGAAGACCGGATTCAAGAT
TTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAGCTGTGGACGTGGCTGGAG
GAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGCTTTGGCCAGCAGCAGCAG
ACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCCATCTCCAGTAACAAGACC
CCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAGGAGCTCTTCCAGGAGCGC
AAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTCGAGTCTTGGAATGATGAG
CTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCAGACAAAGCCTTGACCATG
AACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCTGGTGTGGAGCTGCTGTGT
GATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTGGATTTAGCCGCAGAGCAG
CATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGGATCCGCAACGGAGAGTCC
ATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAGTTCCAGCATGCCATTGAG
AAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATGGACATGATCCGGGACTGC
GCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCCTCTGTCGCTTTCTACAAA
ACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGCGGGGCGGATAAGCTGGGC
CCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAGGCTTGCACCCTTGCTCGG
AGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATCAAAGCTCCTGAACAGCAA
GTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGACGGCTGGACCAGTGTCAG
CAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTTTCCACACACACCTCCACG
GGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACCAAAGAGAGAGTGAAGCTA
TTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACTGCTGTGGATAAGAGGTAC
AGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCCAACAAATCGAGTAAAAGT
CTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTTAATGAAGAGAAGCGGAAA
TCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGGGAATGTATGGATACGTAC
CTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGAAACATGCAAGAAATCTAC
GAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGTTTTGTTACTTGGGCAGAC
AAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGGTCCTATTTTGACGAGATA
CAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTATCAGCTCCTTTTAAAAGAG
CTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAGCGAGCCAATGATGCCATG
CACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTCCAAGTGTGGGACCCAAAA
ACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTGAAAGATTCCAGTGGGAGA
AGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCTTGCAAATTTGCACTGTGG
GTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGGATAAAGCATATCCGCGAA
GTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCCGCCACAAGACAGAAGGGA
AGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCACGGACGTCTCAGAACACG
CTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGCAACGAGCTGACCATCCGA
CGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGACCGCTCCCCAGCGGCAGAA
GGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAACCACAAAGACTCGCTCTCC
GTCTCCAGCAATGACGCCAGTCCACCCGCATCCGTGGCTTCCCTCCAGCCCCACATGATCGGGGCCCAGAGCTCGCCGGGCCCCAAGCGG
CCGGGCAACACCCTGCGCAAGTGGCTCACCAGCCCCGTGCGGCGGCTCAGCAGCGGCAAGGCCGACGGGCACGTGAAGAAGCTGGCGCAC
AAGCACAAGAAGAGCCGCGAGGTCCGCAAGAGCGCCGACGCCGGCTCGCAGAAGGACTCCGACGACAGTGCGGCCACCCCGCAGGACGAG
ACGGTCGAGGAGAGAGGCCGGAACGAGGGCCTGAGCAGCGGTACTCTCTCCAAATCCTCCTCCTCGGGGATGCAGAGCTGTGGAGAAGAG
GAAGGCGAGGAGGGGGCCGACGCCGTGCCCCTGCCGCCACCCATGGCCATCCAGCAGCACAGCCTCCTCCAGCCAGACTCACAGGATGAC
AAGGCCTCTTCTCGGTTATTAGTCCGCCCCACCAGCTCCGAAACACCGAGTGCAGCCGAGCTCGTCAGTGCAATTGAGGAACTCGTGAAA
AGCAAGATGGCACTGGAGGATCGCCCCAGCTCACTCCTTGTTGACCAGGGAGATAGTAGCAGCCCTTCCTTCAACCCTTCGGATAATTCC
CTTCTCTCTTCCTCCTCGCCCATTGATGAGATGGAAGAAAGGAAATCCAGCTCTTTAAAGAGAAGACACTACGTTTTGCAAGAACTAGTG
GAGACAGAGCGTGACTATGTGCGGGACCTTGGCTATGTGGTTGAGGGCTACATGGCACTTATGAAAGAAGATGGTGTTCCTGATGACATG
AAAGGAAAAGACAAAATTGTGTTCGGCAACATCCATCAGATTTACGACTGGCACAGAGACTTTTTTTTAGGAGAGTTAGAGAAGTGCCTT
GAAGATCCAGAAAAACTAGGATCCCTTTTTGTTAAACACGTTGTGGAAAATGCCCTTAAAGTGAACCCAATACTAGGTCCACAAATGTTT
CAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCACGTATCTTGGAGTTATGGGTCGA
GTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAGATGGACCAGCTTTTGGGAAAT
ATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTTTGGCTTTGCTCTCTCTTCTGCCA
TCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGATGTCATGACGGAAGATCCTGAA
ACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAGAACCACCCACAGAACAAGATAAG
AGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAGCTCAAGGCACAGCAGGAGATG
CTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGGAGTTTTTGCAAGGATTCTAAGAG
CACATGACATGTGGCTGCCTCCCCTTTCAGAAACAAGCTGAGTAACCCAGCCTGCCGTTTGTATGTGAGAGCCTGCTGAGATGAAGAAAT
CACTTCATGAAAATAAGCAAAGACCACACATTTTTTACTACAAAATGTAAAGGATAAATGTAAATCCTGCATAACTAAAATCACAAACCT
ATTCCTCAAAAGAATTTAATTTTATATTTATGAGGGGGCCCTTCACTAAAAAGTACATGTAAAAGTACATTTGATGACAATAGCTGCTTA
GTTTCCTGTTAAGAGAAGAAACTTTATCTTTTAATTATGTGCTCTTAATATTTGAAGATGAGAGTTAATACCTGAGATGTTTTTCTGCAA
CCAAAATTCATTAAATTTGGCTGCCTTATCCTTTTTTTAAGCTAATGAAACTACAGGTTTGAAAAATGACAAAGCTGTTCAGATGATGCT
ATTAAAGAAATGTGTGTACTAAGCAAAAATATATAAATAGTGACAAATACACATTACCAAGCTTATCTTGCAAGGGAGTTATTTTCATCT
AACATAGAAAGTGTGTTTTATCAGACAAATGCTTTTATTTTCATTCTAATAATTTGATACAGAAATTAGTAAAGGCATTTTTTTCTTTTT
TTTTCCAGTAAATACATTGGGTCTATAAATGTGCATTTGTAAGGGCCACAAAAGTGAACGTGTGGTACTGTAGTACCACGTGGGAGACCT
CTGGTTATGGTTTAGTCCTAGTTCCTTTGTTACTCCTGTGAGCACCGAGAAGAACTGGGCGACTCCCAGTCCCACCTGTGCTGTGACAGT
CCCACGTGGCTATGACAGACTGTTTAGTACTTACCCTTCTCAGGTTCCTCAGTGCAGGGGTGCATCAGGGCCTCAATAATAGGGGTATAC
CTGGGAGGATCCAGCAGTAATCCCCAGGGTACTAGGATTACTAGTACTCTGATGGAACTAGTCTTCCTTCCTTATTCCTCGAACATGCAG
TACATAAAAAGGGGAAAAGGAGAAAAAAAAAGCCTTACTTTGTTTTACTTGCCATTTATTGTAAGGAAACTTTAAAGCATTTTTTAGGAA
ATACTCAAAAGCAAGGTTGGAAAATGTTTTATCTTTCTATAGAAAGTTGGGTACAGTATGTAACTGCGGGAAACCCACTGCCCCTTTGTA

>94205_94205_3_TRIO-IPO11_TRIO_chr5_14477072_ENST00000537187_IPO11_chr5_61846194_ENST00000325324_length(amino acids)=2276AA_BP=2051
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH
KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQPDSQDDKA
SSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET
ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHVVENALKVNPILGPQMFQP
ILPYVFKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSD
NSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEMLG

--------------------------------------------------------------
>94205_94205_4_TRIO-IPO11_TRIO_chr5_14477072_ENST00000537187_IPO11_chr5_61846194_ENST00000409296_length(transcript)=7223nt_BP=6159nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAG
GACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGGTCAGCCAAGATGGGAAGTCGCTC
CTTGACAAGCTCCAGCGGCCCTTGACTCCCGGCAGCTCCGATTCCCTGACAGCCTCTGCCAACTACTCCAAGGCCGTGCACCATGTCCTG
GATGTCATCCACGAGGTGCTGCACCACCAGCGGCAGCTGGAGAACATCTGGCAACACCGCAAGGTCCGGCTGCATCAGAGGCTGCAGCTG
TGTGTTTTCCAGCAGGACGTTCAGCAGGTGCTAGACTGGATCGAGAACCACGGAGAAGCATTTCTGAGCAAACATACAGGTGTGGGGAAA
TCTCTTCATCGGGCCAGAGCATTGCAGAAACGTCATGAAGATTTTGAAGAAGTGGCACAGAACACATACACCAATGCGGATAAATTACTG
GAAGCAGCAGAACAGCTGGCTCAGACTGGGGAATGTGACCCCGAAGAGATTTATCAGGCTGCCCATCAGCTGGAAGACCGGATTCAAGAT
TTCGTTCGGCGTGTTGAGCAGCGAAAGATCCTACTGGACATGTCAGTGTCCTTTCACACCCATGTGAAAGAGCTGTGGACGTGGCTGGAG
GAGCTGCAGAAGGAGCTGCTGGACGACGTGTATGCCGAGTCGGTGGAGGCCGTGCAGGACCTCATCAAGCGCTTTGGCCAGCAGCAGCAG
ACCACCCTGCAGGTGACTGTCAACGTGATCAAGGAAGGGGAGGACCTCATCCAGCAGCTCAGGGACTCTGCCATCTCCAGTAACAAGACC
CCCCACAACAGCTCCATCAACCACATTGAGACGGTGCTGCAGCAGCTGGACGAGGCGCAGTCGCAGATGGAGGAGCTCTTCCAGGAGCGC
AAGATCAAGCTGGAGCTCTTCCTGCAGCTGCGCATCTTCGAGAGGGACGCCATCGACATTATCTCAGACCTCGAGTCTTGGAATGATGAG
CTTTCTCAGCAAATGAATGACTTCGACACAGAAGATCTCACGATTGCAGAGCAGCGCCTCCAGCACCATGCAGACAAAGCCTTGACCATG
AACAACTTGACTTTTGACGTCATCCACCAAGGGCAAGATCTTCTGCAGTATGTCAATGAGGTCCAGGCCTCTGGTGTGGAGCTGCTGTGT
GATAGAGATGTAGACATGGCAACTCGGGTCCAGGACCTGCTGGAGTTTCTTCATGAAAAACAGCAGGAATTGGATTTAGCCGCAGAGCAG
CATCGGAAACACCTGGAGCAGTGCGTGCAGCTGCGCCACCTGCAGGCAGAAGTGAAACAGGTGCTGGGTTGGATCCGCAACGGAGAGTCC
ATGTTAAATGCCGGACTTATCACAGCCAGCTCGTTACAAGAGGCAGAGCAGCTCCAGCGAGAGCACGAGCAGTTCCAGCATGCCATTGAG
AAAACACATCAGAGCGCGCTGCAGGTGCAGCAGAAGGCAGAAGCCATGCTACAGGCCAACCACTACGACATGGACATGATCCGGGACTGC
GCCGAGAAGGTGGCGTCTCACTGGCAACAGCTCATGCTCAAGATGGAAGATCGCCTCAAGCTCGTCAACGCCTCTGTCGCTTTCTACAAA
ACCTCAGAGCAGGTCTGCAGCGTCCTCGAGAGCCTGGAACAGGAGTACAAGAGAGAAGAAGACTGGTGTGGCGGGGCGGATAAGCTGGGC
CCAAACTCTGAGACGGACCACGTGACGCCCATGATCAGCAAGCACCTGGAGCAGAAGGAGGCATTCCTGAAGGCTTGCACCCTTGCTCGG
AGGAATGCAGACGTCTTCCTGAAATACCTGCACAGGAACAGCGTGAACATGCCAGGAATGGTGACGCACATCAAAGCTCCTGAACAGCAA
GTGAAAAATATCTTGAATGAACTCTTCCAACGGGAGAACAGGGTATTGCATTACTGGACCATGAGGAAGAGACGGCTGGACCAGTGTCAG
CAGTACGTGGTCTTTGAGAGGAGTGCCAAGCAGGCTTTGGAATGGATCCATGACAATGGCGAGTTCTACCTTTCCACACACACCTCCACG
GGCTCCAGTATACAGCACACCCAGGAGCTCCTGAAAGAGCACGAGGAGTTCCAGATAACTGCAAAGCAAACCAAAGAGAGAGTGAAGCTA
TTGATACAGCTGGCTGATGGCTTTTGTGAAAAAGGGCATGCCCATGCGGCAGAGATAAAAAAATGTGTTACTGCTGTGGATAAGAGGTAC
AGAGATTTCTCTCTGCGGATGGAGAAGTACAGGACCTCTTTGGAAAAAGCCCTGGGGATTTCTTCAGATTCCAACAAATCGAGTAAAAGT
CTCCAGCTAGATATCATTCCAGCCAGTATCCCTGGCTCAGAGGTGAAACTTCGAGATGCTGCTCATGAACTTAATGAAGAGAAGCGGAAA
TCTGCCCGCAGGAAAGAGTTCATAATGGCTGAGCTCATTCAAACTGAAAAGGCTTATGTAAGAGACCTCCGGGAATGTATGGATACGTAC
CTGTGGGAAATGACCAGTGGCGTGGAAGAGATTCCACCTGGCATTGTAAACAAAGAACTCATCATCTTCGGAAACATGCAAGAAATCTAC
GAATTTCATAATAACATATTCCTAAAGGAGCTGGAAAAATATGAACAGTTGCCAGAGGATGTTGGACATTGTTTTGTTACTTGGGCAGAC
AAGTTTCAGATGTATGTCACATATTGCAAAAATAAGCCTGATTCTACTCAGCTGATATTGGAACATGCAGGGTCCTATTTTGACGAGATA
CAGCAGCGACATGGATTAGCCAATTCCATTTCTTCCTACCTTATTAAACCAGTTCAGCGAATAACGAAGTATCAGCTCCTTTTAAAAGAG
CTGCTGACGTGCTGTGAGGAAGGAAAGGGAGAGATTAAAGATGGCCTGGAGGTGATGCTCAGCGTGCCGAAGCGAGCCAATGATGCCATG
CACCTCAGCATGCTGGAAGGGTTTGATGAAAACATTGAGTCTCAGGGAGAACTCATCCTACAGGAATCCTTCCAAGTGTGGGACCCAAAA
ACCTTAATTCGAAAGGGTCGAGAACGGCATCTCTTCCTTTTTGAAATGTCCTTAGTATTTAGTAAAGAAGTGAAAGATTCCAGTGGGAGA
AGCAAGTACCTTTATAAAAGCAAATTGTTTACCTCAGAGTTGGGTGTCACAGAACATGTTGAAGGAGACCCTTGCAAATTTGCACTGTGG
GTGGGGAGAACACCAACTTCAGATAATAAAATTGTCCTTAAGGCTTCCAGCATAGAGAACAAGCAGGACTGGATAAAGCATATCCGCGAA
GTCATCCAGGAGCGGACGATCCACCTGAAGGGAGCCCTGAAGGAGCCCATTCACATCCCTAAGACCGCTCCCGCCACAAGACAGAAGGGA
AGGAGGGATGGAGAGGATCTGGACAGCCAAGGAGACGGCAGCAGCCAGCCTGATACGATTTCCATCGCCTCACGGACGTCTCAGAACACG
CTGGACAGCGATAAGCTCTCTGGTGGCTGTGAGCTGACAGTGGTGATCCATGACTTCACCGCTTGCAACAGCAACGAGCTGACCATCCGA
CGGGGCCAGACCGTGGAAGTTCTGGAGCGGCCGCATGACAAGCCTGACTGGTGTCTGGTGCGGACAACTGACCGCTCCCCAGCGGCAGAA
GGCCTGGTCCCCTGTGGTTCACTGTGCATCGCCCACTCCAGAAGTAGCATGGAAATGGAGGGCATCTTCAACCACAAAGACTCGCTCTCC
GTCTCCAGCAATGACGCCAGTCCACCCGCATCCGTGGCTTCCCTCCAGCCCCACATGATCGGGGCCCAGAGCTCGCCGGGCCCCAAGCGG
CCGGGCAACACCCTGCGCAAGTGGCTCACCAGCCCCGTGCGGCGGCTCAGCAGCGGCAAGGCCGACGGGCACGTGAAGAAGCTGGCGCAC
AAGCACAAGAAGAGCCGCGAGGTCCGCAAGAGCGCCGACGCCGGCTCGCAGAAGGACTCCGACGACAGTGCGGCCACCCCGCAGGACGAG
ACGGTCGAGGAGAGAGGCCGGAACGAGGGCCTGAGCAGCGGTACTCTCTCCAAATCCTCCTCCTCGGGGATGCAGAGCTGTGGAGAAGAG
GAAGGCGAGGAGGGGGCCGACGCCGTGCCCCTGCCGCCACCCATGGCCATCCAGCAGCACAGCCTCCTCCAGCCAGACTCACAGGATGAC
AAGGCCTCTTCTCGGTTATTAGTCCGCCCCACCAGCTCCGAAACACCGAGTGCAGCCGAGCTCGTCAGTGCAATTGAGGAACTCGTGAAA
AGCAAGATGGCACTGGAGGATCGCCCCAGCTCACTCCTTGTTGACCAGGGAGATAGTAGCAGCCCTTCCTTCAACCCTTCGGATAATTCC
CTTCTCTCTTCCTCCTCGCCCATTGATGAGATGGAAGAAAGGAAATCCAGCTCTTTAAAGAGAAGACACTACGTTTTGCAAGAACTAGTG
GAGACAGAGCGTGACTATGTGCGGGACCTTGGCTATGTGGTTGAGGGCTACATGGCACTTATGAAAGAAGATGGTGTTCCTGATGACATG
AAAGGAAAAGACAAAATTGTGTTCGGCAACATCCATCAGATTTACGACTGGCACAGAGACTTTTTTTTAGGAGAGTTAGAGAAGTGCCTT
GAAGATCCAGAAAAACTAGGATCCCTTTTTGTTAAACACGTTGTGGAAAATGCCCTTAAAGTGAACCCAATACTAGGTCCACAAATGTTT
CAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCACGTATCTTGGAGTTATGGGTCGA
GTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAGATGGACCAGCTTTTGGGAAAT
ATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTTTGGCTTTGCTCTCTCTTCTGCCA
TCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGATGTCATGACGGAAGATCCTGAA
ACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAGAACCACCCACAGAACAAGATAAG
AGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAGCTCAAGGCACAGCAGGAGATG
CTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGGAGTTTTTGCAAGGATTCTAAGAG
CACATGACATGTGGCTGCCTCCCCTTTCAGAAACAAGCTGAGTAACCCAGCCTGCCGTTTGTATGTGAGAGCCTGCTGAGATGAAGAAAT
CACTTCATGAAAATAAGCAAAGACCACACATTTTTTACTACAAAATGTAAAGGATAAATGTAAATCCTGCATAACTAAAATCACAAACCT
ATTCCTCAAAAGAATTTAATTTTATATTTATGAGGGGGCCCTTCACTAAAAAGTACATGTAAAAGTACATTTGATGACAATAGCTGCTTA
GTTTCCTGTTAAGAGAAGAAACTTTATCTTTTAATTATGTGCTCTTAATATTTGAAGATGAGAGTTAATACCTGAGATGTTTTTCTGCAA

>94205_94205_4_TRIO-IPO11_TRIO_chr5_14477072_ENST00000537187_IPO11_chr5_61846194_ENST00000409296_length(amino acids)=2276AA_BP=2051
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH
KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQPDSQDDKA
SSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET
ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHVVENALKVNPILGPQMFQP
ILPYVFKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSD
NSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEMLG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TRIO-IPO11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TRIO-IPO11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TRIO-IPO11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource