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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIO-IQUB (FusionGDB2 ID:94206)

Fusion Gene Summary for TRIO-IQUB

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO-IQUB
Fusion gene ID: 94206
HgeneTgene
Gene symbol

TRIO

IQUB

Gene ID

7204

154865

Gene nametrio Rho guanine nucleotide exchange factorIQ motif and ubiquitin domain containing
SynonymsARHGEF23|MEBAS|MRD44|tgat-
Cytomap

5p15.2

7q31.32

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)IQ and ubiquitin-like domain-containing protein
Modification date2020031320200313
UniProtAcc

TRIOBP

Q8NA54

Ensembl transtripts involved in fusion geneENST00000344204, ENST00000509967, 
ENST00000537187, ENST00000344135, 
ENST00000515710, 		ENST00000434450, 
ENST00000488987, ENST00000324698, 
ENST00000466202, 
Fusion gene scores* DoF score34 X 28 X 12=114243 X 3 X 3=27
# samples 353
** MAII scorelog2(35/11424*10)=-5.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TRIO [Title/Abstract] AND IQUB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIO(14304701)-IQUB(123097620), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRIO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IQUB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5741-01ATRIOchr5

14304701

-IQUBchr7

123097620

-
ChimerDB4PRADTCGA-CH-5741-01ATRIOchr5

14304701

+IQUBchr7

123097620

-
ChimerDB4PRADTCGA-CH-5741TRIOchr5

14304701

+IQUBchr7

123097620

-


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Fusion Gene ORF analysis for TRIO-IQUB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344204ENST00000434450TRIOchr5

14304701

+IQUBchr7

123097620

-
5CDS-intronENST00000344204ENST00000488987TRIOchr5

14304701

+IQUBchr7

123097620

-
5CDS-intronENST00000509967ENST00000434450TRIOchr5

14304701

+IQUBchr7

123097620

-
5CDS-intronENST00000509967ENST00000488987TRIOchr5

14304701

+IQUBchr7

123097620

-
5CDS-intronENST00000537187ENST00000434450TRIOchr5

14304701

+IQUBchr7

123097620

-
5CDS-intronENST00000537187ENST00000488987TRIOchr5

14304701

+IQUBchr7

123097620

-
In-frameENST00000344204ENST00000324698TRIOchr5

14304701

+IQUBchr7

123097620

-
In-frameENST00000344204ENST00000466202TRIOchr5

14304701

+IQUBchr7

123097620

-
In-frameENST00000509967ENST00000324698TRIOchr5

14304701

+IQUBchr7

123097620

-
In-frameENST00000509967ENST00000466202TRIOchr5

14304701

+IQUBchr7

123097620

-
In-frameENST00000537187ENST00000324698TRIOchr5

14304701

+IQUBchr7

123097620

-
In-frameENST00000537187ENST00000466202TRIOchr5

14304701

+IQUBchr7

123097620

-
intron-3CDSENST00000344135ENST00000324698TRIOchr5

14304701

+IQUBchr7

123097620

-
intron-3CDSENST00000344135ENST00000466202TRIOchr5

14304701

+IQUBchr7

123097620

-
intron-3CDSENST00000515710ENST00000324698TRIOchr5

14304701

+IQUBchr7

123097620

-
intron-3CDSENST00000515710ENST00000466202TRIOchr5

14304701

+IQUBchr7

123097620

-
intron-intronENST00000344135ENST00000434450TRIOchr5

14304701

+IQUBchr7

123097620

-
intron-intronENST00000344135ENST00000488987TRIOchr5

14304701

+IQUBchr7

123097620

-
intron-intronENST00000515710ENST00000434450TRIOchr5

14304701

+IQUBchr7

123097620

-
intron-intronENST00000515710ENST00000488987TRIOchr5

14304701

+IQUBchr7

123097620

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344204TRIOchr514304701+ENST00000466202IQUBchr7123097620-22361524241892622
ENST00000344204TRIOchr514304701+ENST00000324698IQUBchr7123097620-22311524241892622
ENST00000537187TRIOchr514304701+ENST00000466202IQUBchr7123097620-2218150661874622
ENST00000537187TRIOchr514304701+ENST00000324698IQUBchr7123097620-2213150661874622
ENST00000509967TRIOchr514304701+ENST00000466202IQUBchr7123097620-221715051521873573
ENST00000509967TRIOchr514304701+ENST00000324698IQUBchr7123097620-221215051521873573

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344204ENST00000466202TRIOchr514304701+IQUBchr7123097620-0.0081161070.9918839
ENST00000344204ENST00000324698TRIOchr514304701+IQUBchr7123097620-0.0082764880.9917235
ENST00000537187ENST00000466202TRIOchr514304701+IQUBchr7123097620-0.0082688990.9917311
ENST00000537187ENST00000324698TRIOchr514304701+IQUBchr7123097620-0.0084388180.99156123
ENST00000509967ENST00000466202TRIOchr514304701+IQUBchr7123097620-0.0075306660.9924694
ENST00000509967ENST00000324698TRIOchr514304701+IQUBchr7123097620-0.0076456750.9923543

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Fusion Genomic Features for TRIO-IQUB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIO-IQUB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:14304701/chr7:123097620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

TRIOBP

IQUB

Q8NA54

2365FUNCTION: May play roles in cilia formation and/or maintenance. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+85765_2105003098.0DomainCRAL-TRIO
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+85865_2105002922.0DomainCRAL-TRIO
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+857311_4185003098.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+858311_4185002922.0RepeatNote=Spectrin 1
TgeneIQUBchr5:14304701chr7:123097620ENST00000434450011131_2070597.0DomainUbiquitin-like
TgeneIQUBchr5:14304701chr7:123097620ENST00000434450011338_3670597.0DomainNote=IQ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1101845_18500597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1102292_23120597.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1102545_25510597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+110715_7180597.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8571845_18505003098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8572292_23125003098.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8572545_25515003098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+857715_7185003098.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8581845_18505002922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8582292_23125002922.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8582545_25515002922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+858715_7185002922.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1101292_14670597.0DomainDH 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1101480_15910597.0DomainPH 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1101656_17210597.0DomainSH3 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1101969_21450597.0DomainDH 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1102157_22710597.0DomainPH 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1102551_26160597.0DomainSH3 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1102685_27750597.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1102796_30520597.0DomainProtein kinase
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+11065_2100597.0DomainCRAL-TRIO
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8571292_14675003098.0DomainDH 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8571480_15915003098.0DomainPH 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8571656_17215003098.0DomainSH3 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8571969_21455003098.0DomainDH 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8572157_22715003098.0DomainPH 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8572551_26165003098.0DomainSH3 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8572685_27755003098.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8572796_30525003098.0DomainProtein kinase
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8581292_14675002922.0DomainDH 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8581480_15915002922.0DomainPH 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8581656_17215002922.0DomainSH3 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8581969_21455002922.0DomainDH 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8582157_22715002922.0DomainPH 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8582551_26165002922.0DomainSH3 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8582685_27755002922.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8582796_30525002922.0DomainProtein kinase
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1102802_28100597.0Nucleotide bindingATP
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8572802_28105003098.0Nucleotide bindingATP
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8582802_28105002922.0Nucleotide bindingATP
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+1101109_12160597.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+110311_4180597.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+110538_6440597.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000344135+110878_9840597.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+8571109_12165003098.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+857538_6445003098.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000344204+857878_9845003098.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+8581109_12165002922.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+858538_6445002922.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14304701chr7:123097620ENST00000537187+858878_9845002922.0RepeatNote=Spectrin 3
TgeneIQUBchr5:14304701chr7:123097620ENST000003246981013131_207669792.0DomainUbiquitin-like
TgeneIQUBchr5:14304701chr7:123097620ENST000003246981013338_367669792.0DomainNote=IQ
TgeneIQUBchr5:14304701chr7:123097620ENST000004662021013131_207669792.0DomainUbiquitin-like
TgeneIQUBchr5:14304701chr7:123097620ENST000004662021013338_367669792.0DomainNote=IQ


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Fusion Gene Sequence for TRIO-IQUB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94206_94206_1_TRIO-IQUB_TRIO_chr5_14304701_ENST00000344204_IQUB_chr7_123097620_ENST00000324698_length(transcript)=2231nt_BP=1524nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGAC
CTTCCCTCAGAGCTGCAGGACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGCTACAA
GACATTCAGTACCTGACAGAGAACATCTGGGCGTCCCAGTCAGTCCTCAGTGCTTGCGACAATCTCAGTGATCTGGTCATGGTCAGATGG
AATAAATCCCTGGAGTGGTCCCCCTGGAACTGCATTCTTCTTACCAAAGATGAAGCAGCTGCTCATCTCAAGCTAACAAGTATTGAAGAG
GGATATGAACGCTCATTTATTCACAAGATCAAACACAAACATATCCTGGCTAAGAACTATTTTTCTCAGGTTCCAGTGCTGGCTTCATTT
ATACTTGATGATGGTGAAATTGATGAGATCAGATGGAAGTATCACTCAGACACAACACCTAAGATTATAGAATCCCAGAGGCCTCCTCAT
TAGGTGATCCAGGAGTATTTGTTTGATGATCGGCATTTTGTTCACTGCTAATAGGGTAATACAGAGGTCACAGAGTATGGAAATGGAATT
TAATCTGTTTATTGATTTTGTTTTTTGTTTTTCATAGTATTTTGAGTTATATAAAGAGAAAACATTTCTATATAAGTAAGTATTCTTTGT
TAGGAAGTTGGTGCTAAATTGAAATGCAATTTTGTTACTGAAATTAATATTTTGGGGTAAAGAAAACATTTTAAAATGTGTTTTCACATT

>94206_94206_1_TRIO-IQUB_TRIO_chr5_14304701_ENST00000344204_IQUB_chr7_123097620_ENST00000324698_length(amino acids)=622AA_BP=500
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSELQDIQYLTENIWASQSVLSACDNLSDLVMVRWNKSLEWSP

--------------------------------------------------------------
>94206_94206_2_TRIO-IQUB_TRIO_chr5_14304701_ENST00000344204_IQUB_chr7_123097620_ENST00000466202_length(transcript)=2236nt_BP=1524nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGAC
CTTCCCTCAGAGCTGCAGGACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGCTACAA
GACATTCAGTACCTGACAGAGAACATCTGGGCGTCCCAGTCAGTCCTCAGTGCTTGCGACAATCTCAGTGATCTGGTCATGGTCAGATGG
AATAAATCCCTGGAGTGGTCCCCCTGGAACTGCATTCTTCTTACCAAAGATGAAGCAGCTGCTCATCTCAAGCTAACAAGTATTGAAGAG
GGATATGAACGCTCATTTATTCACAAGATCAAACACAAACATATCCTGGCTAAGAACTATTTTTCTCAGGTTCCAGTGCTGGCTTCATTT
ATACTTGATGATGGTGAAATTGATGAGATCAGATGGAAGTATCACTCAGACACAACACCTAAGATTATAGAATCCCAGAGGCCTCCTCAT
TAGGTGATCCAGGAGTATTTGTTTGATGATCGGCATTTTGTTCACTGCTAATAGGGTAATACAGAGGTCACAGAGTATGGAAATGGAATT
TAATCTGTTTATTGATTTTGTTTTTTGTTTTTCATAGTATTTTGAGTTATATAAAGAGAAAACATTTCTATATAAGTAAGTATTCTTTGT
TAGGAAGTTGGTGCTAAATTGAAATGCAATTTTGTTACTGAAATTAATATTTTGGGGTAAAGAAAACATTTTAAAATGTGTTTTCACATT

>94206_94206_2_TRIO-IQUB_TRIO_chr5_14304701_ENST00000344204_IQUB_chr7_123097620_ENST00000466202_length(amino acids)=622AA_BP=500
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSELQDIQYLTENIWASQSVLSACDNLSDLVMVRWNKSLEWSP

--------------------------------------------------------------
>94206_94206_3_TRIO-IQUB_TRIO_chr5_14304701_ENST00000509967_IQUB_chr7_123097620_ENST00000324698_length(transcript)=2212nt_BP=1505nt
ATTTGGGATATCTAGAGGTTGTTTGTTGGTGTTCTGGGATCCTGAGGGACACTGCCAACTGTTAACCTTTGGCAGATAGTGACTGTTTTA
CTTCGATTTTATTTTCGTGGTAACCGTTTTTTAAAAAAGATTAATAAATTACCCAAGAGGACATGGCAGAAGGGTTTCGAAAAAACGATG
AAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTAA
CGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAGG
TCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCCT
TCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAAT
TTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATACA
ACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAGG
ACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATTA
AGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGCT
CAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATGT
GGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACACA
ACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCCA
TGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAGA
TCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCCA
TTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAGG
ACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGCTACAAGACATTCAGTACCTGACAG
AGAACATCTGGGCGTCCCAGTCAGTCCTCAGTGCTTGCGACAATCTCAGTGATCTGGTCATGGTCAGATGGAATAAATCCCTGGAGTGGT
CCCCCTGGAACTGCATTCTTCTTACCAAAGATGAAGCAGCTGCTCATCTCAAGCTAACAAGTATTGAAGAGGGATATGAACGCTCATTTA
TTCACAAGATCAAACACAAACATATCCTGGCTAAGAACTATTTTTCTCAGGTTCCAGTGCTGGCTTCATTTATACTTGATGATGGTGAAA
TTGATGAGATCAGATGGAAGTATCACTCAGACACAACACCTAAGATTATAGAATCCCAGAGGCCTCCTCATTAGGTGATCCAGGAGTATT
TGTTTGATGATCGGCATTTTGTTCACTGCTAATAGGGTAATACAGAGGTCACAGAGTATGGAAATGGAATTTAATCTGTTTATTGATTTT
GTTTTTTGTTTTTCATAGTATTTTGAGTTATATAAAGAGAAAACATTTCTATATAAGTAAGTATTCTTTGTTAGGAAGTTGGTGCTAAAT
TGAAATGCAATTTTGTTACTGAAATTAATATTTTGGGGTAAAGAAAACATTTTAAAATGTGTTTTCACATTAAATTTTTTAAATTTTTTC

>94206_94206_3_TRIO-IQUB_TRIO_chr5_14304701_ENST00000509967_IQUB_chr7_123097620_ENST00000324698_length(amino acids)=573AA_BP=451
MAEGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIK
PLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATH
MLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLH
STRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLV
ESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYS
ELQDIQYLTENIWASQSVLSACDNLSDLVMVRWNKSLEWSPWNCILLTKDEAAAHLKLTSIEEGYERSFIHKIKHKHILAKNYFSQVPVL

--------------------------------------------------------------
>94206_94206_4_TRIO-IQUB_TRIO_chr5_14304701_ENST00000509967_IQUB_chr7_123097620_ENST00000466202_length(transcript)=2217nt_BP=1505nt
ATTTGGGATATCTAGAGGTTGTTTGTTGGTGTTCTGGGATCCTGAGGGACACTGCCAACTGTTAACCTTTGGCAGATAGTGACTGTTTTA
CTTCGATTTTATTTTCGTGGTAACCGTTTTTTAAAAAAGATTAATAAATTACCCAAGAGGACATGGCAGAAGGGTTTCGAAAAAACGATG
AAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTAA
CGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAGG
TCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCCT
TCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAAT
TTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATACA
ACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAGG
ACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATTA
AGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGCT
CAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATGT
GGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACACA
ACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCCA
TGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAGA
TCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCCA
TTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAGG
ACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGCTACAAGACATTCAGTACCTGACAG
AGAACATCTGGGCGTCCCAGTCAGTCCTCAGTGCTTGCGACAATCTCAGTGATCTGGTCATGGTCAGATGGAATAAATCCCTGGAGTGGT
CCCCCTGGAACTGCATTCTTCTTACCAAAGATGAAGCAGCTGCTCATCTCAAGCTAACAAGTATTGAAGAGGGATATGAACGCTCATTTA
TTCACAAGATCAAACACAAACATATCCTGGCTAAGAACTATTTTTCTCAGGTTCCAGTGCTGGCTTCATTTATACTTGATGATGGTGAAA
TTGATGAGATCAGATGGAAGTATCACTCAGACACAACACCTAAGATTATAGAATCCCAGAGGCCTCCTCATTAGGTGATCCAGGAGTATT
TGTTTGATGATCGGCATTTTGTTCACTGCTAATAGGGTAATACAGAGGTCACAGAGTATGGAAATGGAATTTAATCTGTTTATTGATTTT
GTTTTTTGTTTTTCATAGTATTTTGAGTTATATAAAGAGAAAACATTTCTATATAAGTAAGTATTCTTTGTTAGGAAGTTGGTGCTAAAT
TGAAATGCAATTTTGTTACTGAAATTAATATTTTGGGGTAAAGAAAACATTTTAAAATGTGTTTTCACATTAAATTTTTTAAATTTTTTC

>94206_94206_4_TRIO-IQUB_TRIO_chr5_14304701_ENST00000509967_IQUB_chr7_123097620_ENST00000466202_length(amino acids)=573AA_BP=451
MAEGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIK
PLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATH
MLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLH
STRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLV
ESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYS
ELQDIQYLTENIWASQSVLSACDNLSDLVMVRWNKSLEWSPWNCILLTKDEAAAHLKLTSIEEGYERSFIHKIKHKHILAKNYFSQVPVL

--------------------------------------------------------------
>94206_94206_5_TRIO-IQUB_TRIO_chr5_14304701_ENST00000537187_IQUB_chr7_123097620_ENST00000324698_length(transcript)=2213nt_BP=1506nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAG
GACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGCTACAAGACATTCAGTACCTGACA
GAGAACATCTGGGCGTCCCAGTCAGTCCTCAGTGCTTGCGACAATCTCAGTGATCTGGTCATGGTCAGATGGAATAAATCCCTGGAGTGG
TCCCCCTGGAACTGCATTCTTCTTACCAAAGATGAAGCAGCTGCTCATCTCAAGCTAACAAGTATTGAAGAGGGATATGAACGCTCATTT
ATTCACAAGATCAAACACAAACATATCCTGGCTAAGAACTATTTTTCTCAGGTTCCAGTGCTGGCTTCATTTATACTTGATGATGGTGAA
ATTGATGAGATCAGATGGAAGTATCACTCAGACACAACACCTAAGATTATAGAATCCCAGAGGCCTCCTCATTAGGTGATCCAGGAGTAT
TTGTTTGATGATCGGCATTTTGTTCACTGCTAATAGGGTAATACAGAGGTCACAGAGTATGGAAATGGAATTTAATCTGTTTATTGATTT
TGTTTTTTGTTTTTCATAGTATTTTGAGTTATATAAAGAGAAAACATTTCTATATAAGTAAGTATTCTTTGTTAGGAAGTTGGTGCTAAA
TTGAAATGCAATTTTGTTACTGAAATTAATATTTTGGGGTAAAGAAAACATTTTAAAATGTGTTTTCACATTAAATTTTTTAAATTTTTT

>94206_94206_5_TRIO-IQUB_TRIO_chr5_14304701_ENST00000537187_IQUB_chr7_123097620_ENST00000324698_length(amino acids)=622AA_BP=500
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSELQDIQYLTENIWASQSVLSACDNLSDLVMVRWNKSLEWSP

--------------------------------------------------------------
>94206_94206_6_TRIO-IQUB_TRIO_chr5_14304701_ENST00000537187_IQUB_chr7_123097620_ENST00000466202_length(transcript)=2218nt_BP=1506nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGTATATGAGCAACGTGGATTCATGGTGTAAAGCTTGCGGTGAGGTAGACCTTCCCTCAGAGCTGCAG
GACCTAGAAGATGCCATTCATCACCACCAGGGAATATATGAACATATCACTCTTGCTTATTCTGAGCTACAAGACATTCAGTACCTGACA
GAGAACATCTGGGCGTCCCAGTCAGTCCTCAGTGCTTGCGACAATCTCAGTGATCTGGTCATGGTCAGATGGAATAAATCCCTGGAGTGG
TCCCCCTGGAACTGCATTCTTCTTACCAAAGATGAAGCAGCTGCTCATCTCAAGCTAACAAGTATTGAAGAGGGATATGAACGCTCATTT
ATTCACAAGATCAAACACAAACATATCCTGGCTAAGAACTATTTTTCTCAGGTTCCAGTGCTGGCTTCATTTATACTTGATGATGGTGAA
ATTGATGAGATCAGATGGAAGTATCACTCAGACACAACACCTAAGATTATAGAATCCCAGAGGCCTCCTCATTAGGTGATCCAGGAGTAT
TTGTTTGATGATCGGCATTTTGTTCACTGCTAATAGGGTAATACAGAGGTCACAGAGTATGGAAATGGAATTTAATCTGTTTATTGATTT
TGTTTTTTGTTTTTCATAGTATTTTGAGTTATATAAAGAGAAAACATTTCTATATAAGTAAGTATTCTTTGTTAGGAAGTTGGTGCTAAA
TTGAAATGCAATTTTGTTACTGAAATTAATATTTTGGGGTAAAGAAAACATTTTAAAATGTGTTTTCACATTAAATTTTTTAAATTTTTT

>94206_94206_6_TRIO-IQUB_TRIO_chr5_14304701_ENST00000537187_IQUB_chr7_123097620_ENST00000466202_length(amino acids)=622AA_BP=500
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSELQDIQYLTENIWASQSVLSACDNLSDLVMVRWNKSLEWSP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRIO-IQUB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIO-IQUB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIO-IQUB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource