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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIO-KDSR (FusionGDB2 ID:94207)

Fusion Gene Summary for TRIO-KDSR

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO-KDSR
Fusion gene ID: 94207
HgeneTgene
Gene symbol

TRIO

KDSR

Gene ID

7204

2531

Gene nametrio Rho guanine nucleotide exchange factor3-ketodihydrosphingosine reductase
SynonymsARHGEF23|MEBAS|MRD44|tgatDHSR|EKVP4|FVT1|SDR35C1
Cytomap

5p15.2

18q21.33

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)3-ketodihydrosphingosine reductase3-dehydrosphinganine reductaseFVT-1KDS reductasefollicular lymphoma variant translocation 1follicular variant translocation protein 1short chain dehydrogenase/reductase family 35C member 1
Modification date2020031320200313
UniProtAcc

TRIOBP

Q06136

Ensembl transtripts involved in fusion geneENST00000344204, ENST00000509967, 
ENST00000537187, ENST00000344135, 
ENST00000515710, 		ENST00000326575, 
ENST00000589592, ENST00000406396, 
Fusion gene scores* DoF score34 X 28 X 12=114244 X 4 X 3=48
# samples 354
** MAII scorelog2(35/11424*10)=-5.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIO [Title/Abstract] AND KDSR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIO(14297372)-KDSR(61006116), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKDSR

GO:0006666

3-keto-sphinganine metabolic process

15364918


check buttonFusion gene breakpoints across TRIO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KDSR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AY-6196-01ATRIOchr5

14297372

-KDSRchr18

61006116

-


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Fusion Gene ORF analysis for TRIO-KDSR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000344204ENST00000326575TRIOchr5

14297372

-KDSRchr18

61006116

-
5CDS-5UTRENST00000344204ENST00000589592TRIOchr5

14297372

-KDSRchr18

61006116

-
5CDS-5UTRENST00000509967ENST00000326575TRIOchr5

14297372

-KDSRchr18

61006116

-
5CDS-5UTRENST00000509967ENST00000589592TRIOchr5

14297372

-KDSRchr18

61006116

-
5CDS-5UTRENST00000537187ENST00000326575TRIOchr5

14297372

-KDSRchr18

61006116

-
5CDS-5UTRENST00000537187ENST00000589592TRIOchr5

14297372

-KDSRchr18

61006116

-
In-frameENST00000344204ENST00000406396TRIOchr5

14297372

-KDSRchr18

61006116

-
In-frameENST00000509967ENST00000406396TRIOchr5

14297372

-KDSRchr18

61006116

-
In-frameENST00000537187ENST00000406396TRIOchr5

14297372

-KDSRchr18

61006116

-
intron-3CDSENST00000344135ENST00000406396TRIOchr5

14297372

-KDSRchr18

61006116

-
intron-3CDSENST00000515710ENST00000406396TRIOchr5

14297372

-KDSRchr18

61006116

-
intron-5UTRENST00000344135ENST00000326575TRIOchr5

14297372

-KDSRchr18

61006116

-
intron-5UTRENST00000344135ENST00000589592TRIOchr5

14297372

-KDSRchr18

61006116

-
intron-5UTRENST00000515710ENST00000326575TRIOchr5

14297372

-KDSRchr18

61006116

-
intron-5UTRENST00000515710ENST00000589592TRIOchr5

14297372

-KDSRchr18

61006116

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344204TRIOchr514297372-ENST00000406396KDSRchr1861006116-57541392241697557
ENST00000537187TRIOchr514297372-ENST00000406396KDSRchr1861006116-5736137461679557
ENST00000509967TRIOchr514297372-ENST00000406396KDSRchr1861006116-573513731521678508

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344204ENST00000406396TRIOchr514297372-KDSRchr1861006116-0.0004665230.99953353
ENST00000537187ENST00000406396TRIOchr514297372-KDSRchr1861006116-0.000469310.9995307
ENST00000509967ENST00000406396TRIOchr514297372-KDSRchr1861006116-0.0005179760.9994821

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Fusion Genomic Features for TRIO-KDSR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIO-KDSR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:14297372/chr18:61006116)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

TRIOBP

KDSR

Q06136

2365FUNCTION: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). {ECO:0000269|PubMed:28575652}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-75765_2104563098.0DomainCRAL-TRIO
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-75865_2104562922.0DomainCRAL-TRIO
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-757311_4184563098.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-758311_4184562922.0RepeatNote=Spectrin 1
TgeneKDSRchr5:14297372chr18:61006116ENST00000406396610292_293231333.0Topological domainLumenal
TgeneKDSRchr5:14297372chr18:61006116ENST00000406396610315_332231333.0Topological domainCytoplasmic
TgeneKDSRchr5:14297372chr18:61006116ENST00000406396610271_291231333.0TransmembraneHelical
TgeneKDSRchr5:14297372chr18:61006116ENST00000406396610294_314231333.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1101845_18500597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1102292_23120597.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1102545_25510597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-110715_7180597.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7571845_18504563098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7572292_23124563098.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7572545_25514563098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-757715_7184563098.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7581845_18504562922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7582292_23124562922.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7582545_25514562922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-758715_7184562922.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1101292_14670597.0DomainDH 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1101480_15910597.0DomainPH 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1101656_17210597.0DomainSH3 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1101969_21450597.0DomainDH 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1102157_22710597.0DomainPH 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1102551_26160597.0DomainSH3 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1102685_27750597.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1102796_30520597.0DomainProtein kinase
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-11065_2100597.0DomainCRAL-TRIO
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7571292_14674563098.0DomainDH 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7571480_15914563098.0DomainPH 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7571656_17214563098.0DomainSH3 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7571969_21454563098.0DomainDH 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7572157_22714563098.0DomainPH 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7572551_26164563098.0DomainSH3 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7572685_27754563098.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7572796_30524563098.0DomainProtein kinase
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7581292_14674562922.0DomainDH 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7581480_15914562922.0DomainPH 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7581656_17214562922.0DomainSH3 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7581969_21454562922.0DomainDH 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7582157_22714562922.0DomainPH 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7582551_26164562922.0DomainSH3 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7582685_27754562922.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7582796_30524562922.0DomainProtein kinase
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1102802_28100597.0Nucleotide bindingATP
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7572802_28104563098.0Nucleotide bindingATP
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7582802_28104562922.0Nucleotide bindingATP
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-1101109_12160597.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-110311_4180597.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-110538_6440597.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000344135-110878_9840597.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-7571109_12164563098.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-757538_6444563098.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000344204-757878_9844563098.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-7581109_12164562922.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-758538_6444562922.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14297372chr18:61006116ENST00000537187-758878_9844562922.0RepeatNote=Spectrin 3
TgeneKDSRchr5:14297372chr18:61006116ENST0000040639661036_60231333.0Nucleotide bindingNADP
TgeneKDSRchr5:14297372chr18:61006116ENST0000040639661026_270231333.0Topological domainCytoplasmic


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Fusion Gene Sequence for TRIO-KDSR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94207_94207_1_TRIO-KDSR_TRIO_chr5_14297372_ENST00000344204_KDSR_chr18_61006116_ENST00000406396_length(transcript)=5754nt_BP=1392nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGCGAGGAGGTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTG
AAGATCCTGCAGGAGTCCTTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTT
GGCAGTTCTAAATTTGAATTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTT
GATGGCTGCCTGGAATACAACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCT
CGGCTGGAGGAACTTCAGGACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAG
CTGAAGAAGAAGGTGATTAAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTT
CCCAAAAAGAACTCAGGCTCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGG
CAGCATCTGCACCAGATGTGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATG
TTTGACTGGATCACACACAACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACG
CAGCACAATCACTTTGCCATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGC
CACTATGCCTCGCAGCAGATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACC
TTGCTGGACATGTCCTCCATTTTCCACCAGAAGGCCGAAAAGCCTTTGGAGACTCGACTTATTTCAGAGACCACATCTGTGTGCAAACCA
GAACAGGTGGCCAAACAAATTGTTAAAGATGCCATACAAGGAAATTTCAACAGTTCCCTTGGCTCAGATGGGTACATGCTCTCGGCCCTG
ACCTGTGGGATGGCTCCAGTAACTTCTATTACTGAGGGGCTCCAGCAGGTGGTCACCATGGGCCTTTTCCGCACTATTGCTTTGTTTTAC
CTTGGAAGTTTTGACAGCATAGTTCGTCGCTGCATGATGCAGAGAGAAAAATCTGAAAATGCAGACAAAACTGCCTAATCTTCTTACCCC
TTGGAAGAAGACTGTTTCCAAATAATTTGAACAGCTTGCTGCTAAATGGGACCCAATTTTTGGCCTATAGACACTTATGTATTGTTTTCG
AATACGTCAGATTGGACCAGTGCTCTTCAGGAATGTGGCTGCAAGCAAGGGGCTAGAAGTTCACCTCCTGACAGTATTATTAATACTATG
CAAATATGGAATAGGAGACCATTTGATTTTCTAGGCTTTGTGGTAGAGAGGTGAAGGTATGAGAATTAATAGCGTGTGAACAAAGTAAAG
AACAGGATTCCAGAATGATCATTAAATTTGTTTCTATTTATTCTTTTTTGCCCCCCTAGAGATTAAGTCCAGAAATGTACTTTCTGGCAC
ATAAAGAAATCTTGAGGACTTTGTTTAAACCTTCCATAAAAAAACAATTTTCGGTTTCTCGGGTTCTCTCTCTCTCTCTCTCTGTCTCTC
TGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTCTCTCTCTCTCTTTCTTTCTTTGTGTATTTTATTCAAGATGAGTTGGAC
CCATTGCCAGTGAGTCTGAATGTCACTGACAGCCCTGTGTTGTGCTCAGGACTCACTCTGCTGCTGGTGGAAACTCATGGCTTCTCTCTC
TCTTTGATCCCATAAAGCTACGAGGGGGACGGGAGAGGGCAGTGCAATGGGAAGTAAAGAGATATTTTCCAGTAGGAAAAGCAATGCTTT
CTTGTCTTTAGACTCAAATGCTTAGGGAACGTTTCATTTCTCATTCATGGGGAAAGGCAGCCTCCTTAAATGTTTTCTGAAGAGCGGTAA
AATCTAGAAGCTTAAGAATTTACAGTTCCTTCAATAACCATGATGACCTGAAGTTCACCTATCCCATTTTAGCATCTACTTGTTTTTCCC
ATCTCTTCCTTTCCAATTTTGCTTATACTGCTGTAATATTTTTGTAAAAAAAAAAAAAAAGGAAAAAAAAGACCAGCTAAAATTTTCGAC
TTGACTTTTTAACTTAACTCATGAATTAATTAAAGCAAATGAAAAAATTAAAAAGTGTGACTTTTTCTCGGAGCATATATGTAGCTTTTA
GGAAAGGCTGATGATGGTATAAAGTTTGCTCATTAAGAAAAAAAGACAAGGCTGATTTTGAAGAGAGTTGCTTTTGAAATAAAATGATCA
CCTGTTCTTTATGTGACTCTCCCACTGAACCTGCAGACATTATTTTTATACCACATGCTAAGGAAGCCCACTCATCTAACTCTGTAGCCC
TGGAAACCCTCTTGGCCCCTGAATGTTGTTTCCAGGTTATAGGATCTGTGTTCATTAGTGGATTTTGACAGCAAGTGCCTCTGATGAGTT
TTAGCCAACATTCCCCGTTGCATCCTGCTCATTGTTCACACTCCTCTGACTTGAGGAGAGCTGCCTTCACCTTGATCTTGTAACCTGTCT
TCCTTGCATATACGGTAGCACATTCCAGATCACTTCGGTGAGAAAAGACCTCTGTTTTTGAAGAGGAAACTTTCTTAAATTGTAAAATAA
AACTTAAAAAACATAAAAACTCTATACAAAAATTGAAGACCTAAAAATTATAGCATACCTTTTTTTTGCTCTTGAGTTTTTGAAGCTCTT
GACTTTAAATGACTTAACTTTTTAAAAAATAAGATGTTTTATGGCTTTAACCCATGTTTTTATTAAGATCTGAGAATAGCATATTTTAAA
CACTGATAGATACAGAAGAAATTATTATTTAATATATAAATTGCTTGGAATGATTTCATTGCAGCTTGTAAGGATGGGTTGATGCCAGAA
TGGTTTCATAAATCTTTCAGTCTTACAGAGCCAAAGTTTGCAGATTATATCGAGTTGCGTTGTGCAGCTGCTAAAATGGAATCATAGCTT
TTTATAATTTGCAGAAAACAATTGCATTAATGTCTGGATGTTTCTCAGTTTTATTCTTTTCTCATAAATGTTCCTCGAATGTTGGCACCT
TCTACTGCTGATCTATATTAGAATCTAGTCCAAGAAAGTGTCTGATTTAATAACATTAAATAGTTATTTCAATATATTTTTTCAAATTAT
CCTCATAGAACCTGTTGCCTCCAGTGAGATGGTAATCTACTACCCGAATAAATTTAAGAGCACCTGTTGAGAGCCCCTGTTTTGCGGTAG
AAGACAATTGTCCCTATCCCAATTTCCACTGAAATATGAGAGCAGATTTGCAGAGACCATCATGTCAGAGAAGAAATTTCCTTGTCAGAG
ATGTTAAAGGGCTACAGTCCCTTAGCAAAGAAACTTCGAAATCTAAGTTGGTTTGTGTTTTTCTAAATTTGATACCGTAATTCATTTGGC
AGCAAAATCTGACTTGAACTGATGTGAGAGTATTGTACTTTATATTTATGCTACTTCATTGTGACTTAATTTTCCCTGAAGAAATATCCA
TGGATTTGATTATAGGTTTTCCCTTAGATGCTGTGGAGGTGTTTTGTAATATTCAAAATATGCCCATATTGCCTTTTTAAAACCCCAAAG
ATTATGAATTCTGAAACACATCCAGCCCAGCGGGTTTTGGATAAGGGGTTGTAGGCATTTAAGCAGCCTCACATAATGGGCTGACTTCAT
CCAAAACATGAAAATATTACAAGGCAAATTCTATTTTTTATATTTTTTGGTTCAATGCTTGAACAACTTGTTTTTCTGCTGGGGGAAGAA
AAAAAGAACCAACCCTGAGTGTGATTGTTACGGAAACTAATGACTTTGTTTTTAAAGGATCACATTGATTCAACACCTTCTATTGGACCC
AGAAGTGCGTAAATATTACCTATGGTAGTAAACGTTTAATTATCATTCAGTTTAAATGTTGGCCTTCTGTATGTAGCCAAGAACAGCTCA
TTTTGTGAATTTCAGTTTTTAAGTGGCTGCTTTTTGATTTGGTTGTATTATTTTATTATAATGTATTTGCAAGTATATTAAAAAATTAAC
ATTGAGCCATAAAAATCCCCAAATATGTTCAAGGACTTCATAATTGAAAAATATATAGAAAACAATCCTTACTTCTTTTTACAAAAACAA
AATCATGGGAATTATTCTTTTCTATATATTTAGTTATAAATCTTTCTCTGGGCCGGGCGTGGTGGCTCACGCCAGTAATCCCAGCACTTT
GGGAGGCTGAGACAGGCGAATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTGAAAATACAAAA
AATTAGCTGGACACGGTGGCAGGCGCCTGTGTGTGGCGGGCGCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGG
CAGAGGTTGCAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTAGGTGACAGTGCGAGACTCTGTCTCAAAAAAAAAAAAAAAGAAAAA
AAATCTTTATCTGGATCTGTTAAACCATATATTATTGATCATTGCAAGTGAAATTTTGAGAGATTGTTTCTAGTATTTAGGTGATGAAAA
CATTTGGTAATATTGCTTTGGTTCAAAGAATTTTATGTCTTTATCTTTCTAGAAGAAAGCAATTATATATATATTTTTGCTAAATTACAT
AAACATTTAATTACATCAGGTTCTAATTTAAACATGTATTACTCACTTGAGGCCACTTTTAAATATTCATACTCTTTGACATAAGATGCT
TTGTATATTTCTCATTTCTTTTAGTTCTTAGTAAGTCAGCTTTAAAAAGTACCTGCCAACCAGAACCTTCCATATTCTGGACTAAATCTT
GCTCTTCGGATTATACTTCAGTGCAGTAACTGTGGATTTGCAATTTTGAAGGGGAGATAGTAGCTATTATATTTTACACTTGCTTGATGT
GATAACTCTAAAGACTTTTTAACTGATAAAAGCGCACATGGCTATTTTGATACACAAAGTTGTGTTTGCTACTTTAGAAGCTTTTGTGGC

>94207_94207_1_TRIO-KDSR_TRIO_chr5_14297372_ENST00000344204_KDSR_chr18_61006116_ENST00000406396_length(amino acids)=557AA_BP=456
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDSIV

--------------------------------------------------------------
>94207_94207_2_TRIO-KDSR_TRIO_chr5_14297372_ENST00000509967_KDSR_chr18_61006116_ENST00000406396_length(transcript)=5735nt_BP=1373nt
ATTTGGGATATCTAGAGGTTGTTTGTTGGTGTTCTGGGATCCTGAGGGACACTGCCAACTGTTAACCTTTGGCAGATAGTGACTGTTTTA
CTTCGATTTTATTTTCGTGGTAACCGTTTTTTAAAAAAGATTAATAAATTACCCAAGAGGACATGGCAGAAGGGTTTCGAAAAAACGATG
AAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTAA
CGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAGG
TCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCCT
TCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAAT
TTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATACA
ACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAGG
ACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATTA
AGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGCT
CAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATGT
GGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACACA
ACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCCA
TGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAGA
TCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCCA
TTTTCCACCAGAAGGCCGAAAAGCCTTTGGAGACTCGACTTATTTCAGAGACCACATCTGTGTGCAAACCAGAACAGGTGGCCAAACAAA
TTGTTAAAGATGCCATACAAGGAAATTTCAACAGTTCCCTTGGCTCAGATGGGTACATGCTCTCGGCCCTGACCTGTGGGATGGCTCCAG
TAACTTCTATTACTGAGGGGCTCCAGCAGGTGGTCACCATGGGCCTTTTCCGCACTATTGCTTTGTTTTACCTTGGAAGTTTTGACAGCA
TAGTTCGTCGCTGCATGATGCAGAGAGAAAAATCTGAAAATGCAGACAAAACTGCCTAATCTTCTTACCCCTTGGAAGAAGACTGTTTCC
AAATAATTTGAACAGCTTGCTGCTAAATGGGACCCAATTTTTGGCCTATAGACACTTATGTATTGTTTTCGAATACGTCAGATTGGACCA
GTGCTCTTCAGGAATGTGGCTGCAAGCAAGGGGCTAGAAGTTCACCTCCTGACAGTATTATTAATACTATGCAAATATGGAATAGGAGAC
CATTTGATTTTCTAGGCTTTGTGGTAGAGAGGTGAAGGTATGAGAATTAATAGCGTGTGAACAAAGTAAAGAACAGGATTCCAGAATGAT
CATTAAATTTGTTTCTATTTATTCTTTTTTGCCCCCCTAGAGATTAAGTCCAGAAATGTACTTTCTGGCACATAAAGAAATCTTGAGGAC
TTTGTTTAAACCTTCCATAAAAAAACAATTTTCGGTTTCTCGGGTTCTCTCTCTCTCTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGT
CTCTCTGTCTCTCTGTCTCTCTCTCTCTCTCTCTTTCTTTCTTTGTGTATTTTATTCAAGATGAGTTGGACCCATTGCCAGTGAGTCTGA
ATGTCACTGACAGCCCTGTGTTGTGCTCAGGACTCACTCTGCTGCTGGTGGAAACTCATGGCTTCTCTCTCTCTTTGATCCCATAAAGCT
ACGAGGGGGACGGGAGAGGGCAGTGCAATGGGAAGTAAAGAGATATTTTCCAGTAGGAAAAGCAATGCTTTCTTGTCTTTAGACTCAAAT
GCTTAGGGAACGTTTCATTTCTCATTCATGGGGAAAGGCAGCCTCCTTAAATGTTTTCTGAAGAGCGGTAAAATCTAGAAGCTTAAGAAT
TTACAGTTCCTTCAATAACCATGATGACCTGAAGTTCACCTATCCCATTTTAGCATCTACTTGTTTTTCCCATCTCTTCCTTTCCAATTT
TGCTTATACTGCTGTAATATTTTTGTAAAAAAAAAAAAAAAGGAAAAAAAAGACCAGCTAAAATTTTCGACTTGACTTTTTAACTTAACT
CATGAATTAATTAAAGCAAATGAAAAAATTAAAAAGTGTGACTTTTTCTCGGAGCATATATGTAGCTTTTAGGAAAGGCTGATGATGGTA
TAAAGTTTGCTCATTAAGAAAAAAAGACAAGGCTGATTTTGAAGAGAGTTGCTTTTGAAATAAAATGATCACCTGTTCTTTATGTGACTC
TCCCACTGAACCTGCAGACATTATTTTTATACCACATGCTAAGGAAGCCCACTCATCTAACTCTGTAGCCCTGGAAACCCTCTTGGCCCC
TGAATGTTGTTTCCAGGTTATAGGATCTGTGTTCATTAGTGGATTTTGACAGCAAGTGCCTCTGATGAGTTTTAGCCAACATTCCCCGTT
GCATCCTGCTCATTGTTCACACTCCTCTGACTTGAGGAGAGCTGCCTTCACCTTGATCTTGTAACCTGTCTTCCTTGCATATACGGTAGC
ACATTCCAGATCACTTCGGTGAGAAAAGACCTCTGTTTTTGAAGAGGAAACTTTCTTAAATTGTAAAATAAAACTTAAAAAACATAAAAA
CTCTATACAAAAATTGAAGACCTAAAAATTATAGCATACCTTTTTTTTGCTCTTGAGTTTTTGAAGCTCTTGACTTTAAATGACTTAACT
TTTTAAAAAATAAGATGTTTTATGGCTTTAACCCATGTTTTTATTAAGATCTGAGAATAGCATATTTTAAACACTGATAGATACAGAAGA
AATTATTATTTAATATATAAATTGCTTGGAATGATTTCATTGCAGCTTGTAAGGATGGGTTGATGCCAGAATGGTTTCATAAATCTTTCA
GTCTTACAGAGCCAAAGTTTGCAGATTATATCGAGTTGCGTTGTGCAGCTGCTAAAATGGAATCATAGCTTTTTATAATTTGCAGAAAAC
AATTGCATTAATGTCTGGATGTTTCTCAGTTTTATTCTTTTCTCATAAATGTTCCTCGAATGTTGGCACCTTCTACTGCTGATCTATATT
AGAATCTAGTCCAAGAAAGTGTCTGATTTAATAACATTAAATAGTTATTTCAATATATTTTTTCAAATTATCCTCATAGAACCTGTTGCC
TCCAGTGAGATGGTAATCTACTACCCGAATAAATTTAAGAGCACCTGTTGAGAGCCCCTGTTTTGCGGTAGAAGACAATTGTCCCTATCC
CAATTTCCACTGAAATATGAGAGCAGATTTGCAGAGACCATCATGTCAGAGAAGAAATTTCCTTGTCAGAGATGTTAAAGGGCTACAGTC
CCTTAGCAAAGAAACTTCGAAATCTAAGTTGGTTTGTGTTTTTCTAAATTTGATACCGTAATTCATTTGGCAGCAAAATCTGACTTGAAC
TGATGTGAGAGTATTGTACTTTATATTTATGCTACTTCATTGTGACTTAATTTTCCCTGAAGAAATATCCATGGATTTGATTATAGGTTT
TCCCTTAGATGCTGTGGAGGTGTTTTGTAATATTCAAAATATGCCCATATTGCCTTTTTAAAACCCCAAAGATTATGAATTCTGAAACAC
ATCCAGCCCAGCGGGTTTTGGATAAGGGGTTGTAGGCATTTAAGCAGCCTCACATAATGGGCTGACTTCATCCAAAACATGAAAATATTA
CAAGGCAAATTCTATTTTTTATATTTTTTGGTTCAATGCTTGAACAACTTGTTTTTCTGCTGGGGGAAGAAAAAAAGAACCAACCCTGAG
TGTGATTGTTACGGAAACTAATGACTTTGTTTTTAAAGGATCACATTGATTCAACACCTTCTATTGGACCCAGAAGTGCGTAAATATTAC
CTATGGTAGTAAACGTTTAATTATCATTCAGTTTAAATGTTGGCCTTCTGTATGTAGCCAAGAACAGCTCATTTTGTGAATTTCAGTTTT
TAAGTGGCTGCTTTTTGATTTGGTTGTATTATTTTATTATAATGTATTTGCAAGTATATTAAAAAATTAACATTGAGCCATAAAAATCCC
CAAATATGTTCAAGGACTTCATAATTGAAAAATATATAGAAAACAATCCTTACTTCTTTTTACAAAAACAAAATCATGGGAATTATTCTT
TTCTATATATTTAGTTATAAATCTTTCTCTGGGCCGGGCGTGGTGGCTCACGCCAGTAATCCCAGCACTTTGGGAGGCTGAGACAGGCGA
ATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTGAAAATACAAAAAATTAGCTGGACACGGTGG
CAGGCGCCTGTGTGTGGCGGGCGCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCA
AGATTGCGCCACTGCACTCCAGCCTAGGTGACAGTGCGAGACTCTGTCTCAAAAAAAAAAAAAAAGAAAAAAAATCTTTATCTGGATCTG
TTAAACCATATATTATTGATCATTGCAAGTGAAATTTTGAGAGATTGTTTCTAGTATTTAGGTGATGAAAACATTTGGTAATATTGCTTT
GGTTCAAAGAATTTTATGTCTTTATCTTTCTAGAAGAAAGCAATTATATATATATTTTTGCTAAATTACATAAACATTTAATTACATCAG
GTTCTAATTTAAACATGTATTACTCACTTGAGGCCACTTTTAAATATTCATACTCTTTGACATAAGATGCTTTGTATATTTCTCATTTCT
TTTAGTTCTTAGTAAGTCAGCTTTAAAAAGTACCTGCCAACCAGAACCTTCCATATTCTGGACTAAATCTTGCTCTTCGGATTATACTTC
AGTGCAGTAACTGTGGATTTGCAATTTTGAAGGGGAGATAGTAGCTATTATATTTTACACTTGCTTGATGTGATAACTCTAAAGACTTTT
TAACTGATAAAAGCGCACATGGCTATTTTGATACACAAAGTTGTGTTTGCTACTTTAGAAGCTTTTGTGGCAGAATTGTAATCTAATTTT

>94207_94207_2_TRIO-KDSR_TRIO_chr5_14297372_ENST00000509967_KDSR_chr18_61006116_ENST00000406396_length(amino acids)=508AA_BP=407
MAEGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIK
PLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATH
MLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLH
STRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLV
ESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYML

--------------------------------------------------------------
>94207_94207_3_TRIO-KDSR_TRIO_chr5_14297372_ENST00000537187_KDSR_chr18_61006116_ENST00000406396_length(transcript)=5736nt_BP=1374nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGCGAGGAG
GTCTGCAAGCGTGGCTTCACGGTGATCGTGGACATGCGTGGGTCCAAGTGGGACTCCATCAAGCCCCTTCTGAAGATCCTGCAGGAGTCC
TTCCCCTGCTGCATCCATGTGGCCCTGATCATCAAGCCAGACAACTTCTGGCAGAAACAGAGGACTAATTTTGGCAGTTCTAAATTTGAA
TTTGAGACAAATATGGTCTCTTTAGAAGGCCTTACCAAAGTAGTTGATCCTTCTCAGCTAACTCCTGAGTTTGATGGCTGCCTGGAATAC
AACCACGAAGAATGGATTGAAATCAGAGTTGCTTTTGAAGACTACATTAGCAATGCCACCCACATGCTGTCTCGGCTGGAGGAACTTCAG
GACATCCTAGCTAAGAAGGAGCTGCCTCAGGATTTAGAGGGGGCTCGGAATATGATCGAGGAACATTCTCAGCTGAAGAAGAAGGTGATT
AAGGCCCCCATCGAGGACCTGGATTTGGAGGGACAGAAGCTGCTTCAGAGGATACAGAGCAGTGAAAGCTTTCCCAAAAAGAACTCAGGC
TCAGGCAATGCGGACCTGCAGAACCTCTTGCCCAAGGTGTCCACCATGCTGGACCGGCTGCACTCGACACGGCAGCATCTGCACCAGATG
TGGCATGTGAGGAAGCTGAAGCTGGACCAGTGCTTCCAGCTGAGGCTGTTTGAACAGGATGCTGAGAAGATGTTTGACTGGATCACACAC
AACAAAGGCCTGTTTCTAAACAGCTACACAGAGATTGGGACCAGCCACCCTCATGCCATGGAGCTTCAGACGCAGCACAATCACTTTGCC
ATGAACTGTATGAACGTGTATGTAAATATAAACCGCATCATGTCGGTGGCCAATCGTCTGGTGGAGTCTGGCCACTATGCCTCGCAGCAG
ATCAGGCAGATCGCGAGTCAGCTGGAGCAGGAGTGGAAGGCGTTTGCGGCAGCCCTGGATGAGCGGAGCACCTTGCTGGACATGTCCTCC
ATTTTCCACCAGAAGGCCGAAAAGCCTTTGGAGACTCGACTTATTTCAGAGACCACATCTGTGTGCAAACCAGAACAGGTGGCCAAACAA
ATTGTTAAAGATGCCATACAAGGAAATTTCAACAGTTCCCTTGGCTCAGATGGGTACATGCTCTCGGCCCTGACCTGTGGGATGGCTCCA
GTAACTTCTATTACTGAGGGGCTCCAGCAGGTGGTCACCATGGGCCTTTTCCGCACTATTGCTTTGTTTTACCTTGGAAGTTTTGACAGC
ATAGTTCGTCGCTGCATGATGCAGAGAGAAAAATCTGAAAATGCAGACAAAACTGCCTAATCTTCTTACCCCTTGGAAGAAGACTGTTTC
CAAATAATTTGAACAGCTTGCTGCTAAATGGGACCCAATTTTTGGCCTATAGACACTTATGTATTGTTTTCGAATACGTCAGATTGGACC
AGTGCTCTTCAGGAATGTGGCTGCAAGCAAGGGGCTAGAAGTTCACCTCCTGACAGTATTATTAATACTATGCAAATATGGAATAGGAGA
CCATTTGATTTTCTAGGCTTTGTGGTAGAGAGGTGAAGGTATGAGAATTAATAGCGTGTGAACAAAGTAAAGAACAGGATTCCAGAATGA
TCATTAAATTTGTTTCTATTTATTCTTTTTTGCCCCCCTAGAGATTAAGTCCAGAAATGTACTTTCTGGCACATAAAGAAATCTTGAGGA
CTTTGTTTAAACCTTCCATAAAAAAACAATTTTCGGTTTCTCGGGTTCTCTCTCTCTCTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTG
TCTCTCTGTCTCTCTGTCTCTCTCTCTCTCTCTCTTTCTTTCTTTGTGTATTTTATTCAAGATGAGTTGGACCCATTGCCAGTGAGTCTG
AATGTCACTGACAGCCCTGTGTTGTGCTCAGGACTCACTCTGCTGCTGGTGGAAACTCATGGCTTCTCTCTCTCTTTGATCCCATAAAGC
TACGAGGGGGACGGGAGAGGGCAGTGCAATGGGAAGTAAAGAGATATTTTCCAGTAGGAAAAGCAATGCTTTCTTGTCTTTAGACTCAAA
TGCTTAGGGAACGTTTCATTTCTCATTCATGGGGAAAGGCAGCCTCCTTAAATGTTTTCTGAAGAGCGGTAAAATCTAGAAGCTTAAGAA
TTTACAGTTCCTTCAATAACCATGATGACCTGAAGTTCACCTATCCCATTTTAGCATCTACTTGTTTTTCCCATCTCTTCCTTTCCAATT
TTGCTTATACTGCTGTAATATTTTTGTAAAAAAAAAAAAAAAGGAAAAAAAAGACCAGCTAAAATTTTCGACTTGACTTTTTAACTTAAC
TCATGAATTAATTAAAGCAAATGAAAAAATTAAAAAGTGTGACTTTTTCTCGGAGCATATATGTAGCTTTTAGGAAAGGCTGATGATGGT
ATAAAGTTTGCTCATTAAGAAAAAAAGACAAGGCTGATTTTGAAGAGAGTTGCTTTTGAAATAAAATGATCACCTGTTCTTTATGTGACT
CTCCCACTGAACCTGCAGACATTATTTTTATACCACATGCTAAGGAAGCCCACTCATCTAACTCTGTAGCCCTGGAAACCCTCTTGGCCC
CTGAATGTTGTTTCCAGGTTATAGGATCTGTGTTCATTAGTGGATTTTGACAGCAAGTGCCTCTGATGAGTTTTAGCCAACATTCCCCGT
TGCATCCTGCTCATTGTTCACACTCCTCTGACTTGAGGAGAGCTGCCTTCACCTTGATCTTGTAACCTGTCTTCCTTGCATATACGGTAG
CACATTCCAGATCACTTCGGTGAGAAAAGACCTCTGTTTTTGAAGAGGAAACTTTCTTAAATTGTAAAATAAAACTTAAAAAACATAAAA
ACTCTATACAAAAATTGAAGACCTAAAAATTATAGCATACCTTTTTTTTGCTCTTGAGTTTTTGAAGCTCTTGACTTTAAATGACTTAAC
TTTTTAAAAAATAAGATGTTTTATGGCTTTAACCCATGTTTTTATTAAGATCTGAGAATAGCATATTTTAAACACTGATAGATACAGAAG
AAATTATTATTTAATATATAAATTGCTTGGAATGATTTCATTGCAGCTTGTAAGGATGGGTTGATGCCAGAATGGTTTCATAAATCTTTC
AGTCTTACAGAGCCAAAGTTTGCAGATTATATCGAGTTGCGTTGTGCAGCTGCTAAAATGGAATCATAGCTTTTTATAATTTGCAGAAAA
CAATTGCATTAATGTCTGGATGTTTCTCAGTTTTATTCTTTTCTCATAAATGTTCCTCGAATGTTGGCACCTTCTACTGCTGATCTATAT
TAGAATCTAGTCCAAGAAAGTGTCTGATTTAATAACATTAAATAGTTATTTCAATATATTTTTTCAAATTATCCTCATAGAACCTGTTGC
CTCCAGTGAGATGGTAATCTACTACCCGAATAAATTTAAGAGCACCTGTTGAGAGCCCCTGTTTTGCGGTAGAAGACAATTGTCCCTATC
CCAATTTCCACTGAAATATGAGAGCAGATTTGCAGAGACCATCATGTCAGAGAAGAAATTTCCTTGTCAGAGATGTTAAAGGGCTACAGT
CCCTTAGCAAAGAAACTTCGAAATCTAAGTTGGTTTGTGTTTTTCTAAATTTGATACCGTAATTCATTTGGCAGCAAAATCTGACTTGAA
CTGATGTGAGAGTATTGTACTTTATATTTATGCTACTTCATTGTGACTTAATTTTCCCTGAAGAAATATCCATGGATTTGATTATAGGTT
TTCCCTTAGATGCTGTGGAGGTGTTTTGTAATATTCAAAATATGCCCATATTGCCTTTTTAAAACCCCAAAGATTATGAATTCTGAAACA
CATCCAGCCCAGCGGGTTTTGGATAAGGGGTTGTAGGCATTTAAGCAGCCTCACATAATGGGCTGACTTCATCCAAAACATGAAAATATT
ACAAGGCAAATTCTATTTTTTATATTTTTTGGTTCAATGCTTGAACAACTTGTTTTTCTGCTGGGGGAAGAAAAAAAGAACCAACCCTGA
GTGTGATTGTTACGGAAACTAATGACTTTGTTTTTAAAGGATCACATTGATTCAACACCTTCTATTGGACCCAGAAGTGCGTAAATATTA
CCTATGGTAGTAAACGTTTAATTATCATTCAGTTTAAATGTTGGCCTTCTGTATGTAGCCAAGAACAGCTCATTTTGTGAATTTCAGTTT
TTAAGTGGCTGCTTTTTGATTTGGTTGTATTATTTTATTATAATGTATTTGCAAGTATATTAAAAAATTAACATTGAGCCATAAAAATCC
CCAAATATGTTCAAGGACTTCATAATTGAAAAATATATAGAAAACAATCCTTACTTCTTTTTACAAAAACAAAATCATGGGAATTATTCT
TTTCTATATATTTAGTTATAAATCTTTCTCTGGGCCGGGCGTGGTGGCTCACGCCAGTAATCCCAGCACTTTGGGAGGCTGAGACAGGCG
AATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTGAAAATACAAAAAATTAGCTGGACACGGTG
GCAGGCGCCTGTGTGTGGCGGGCGCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCC
AAGATTGCGCCACTGCACTCCAGCCTAGGTGACAGTGCGAGACTCTGTCTCAAAAAAAAAAAAAAAGAAAAAAAATCTTTATCTGGATCT
GTTAAACCATATATTATTGATCATTGCAAGTGAAATTTTGAGAGATTGTTTCTAGTATTTAGGTGATGAAAACATTTGGTAATATTGCTT
TGGTTCAAAGAATTTTATGTCTTTATCTTTCTAGAAGAAAGCAATTATATATATATTTTTGCTAAATTACATAAACATTTAATTACATCA
GGTTCTAATTTAAACATGTATTACTCACTTGAGGCCACTTTTAAATATTCATACTCTTTGACATAAGATGCTTTGTATATTTCTCATTTC
TTTTAGTTCTTAGTAAGTCAGCTTTAAAAAGTACCTGCCAACCAGAACCTTCCATATTCTGGACTAAATCTTGCTCTTCGGATTATACTT
CAGTGCAGTAACTGTGGATTTGCAATTTTGAAGGGGAGATAGTAGCTATTATATTTTACACTTGCTTGATGTGATAACTCTAAAGACTTT
TTAACTGATAAAAGCGCACATGGCTATTTTGATACACAAAGTTGTGTTTGCTACTTTAGAAGCTTTTGTGGCAGAATTGTAATCTAATTT

>94207_94207_3_TRIO-KDSR_TRIO_chr5_14297372_ENST00000537187_KDSR_chr18_61006116_ENST00000406396_length(amino acids)=557AA_BP=456
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDSIV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRIO-KDSR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIO-KDSR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIO-KDSR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource