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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIO-LIFR (FusionGDB2 ID:94208)

Fusion Gene Summary for TRIO-LIFR

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO-LIFR
Fusion gene ID: 94208
HgeneTgene
Gene symbol

TRIO

LIFR

Gene ID

7204

3977

Gene nametrio Rho guanine nucleotide exchange factorLIF receptor subunit alpha
SynonymsARHGEF23|MEBAS|MRD44|tgatCD118|LIF-R|SJS2|STWS|SWS
Cytomap

5p15.2

5p13.1

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)leukemia inhibitory factor receptorCD118 antigenLIF receptorLIF receptor alphaleukemia inhibitory factor receptor alpha
Modification date2020031320200313
UniProtAcc

TRIOBP

P42702

Ensembl transtripts involved in fusion geneENST00000344204, ENST00000537187, 
ENST00000344135, ENST00000509967, 
ENST00000515710, 		ENST00000503088, 
ENST00000263409, ENST00000453190, 
Fusion gene scores* DoF score34 X 28 X 12=114246 X 5 X 3=90
# samples 356
** MAII scorelog2(35/11424*10)=-5.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIO [Title/Abstract] AND LIFR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIO(14143991)-LIFR(38489347), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLIFR

GO:0008284

positive regulation of cell proliferation

7957045|8999038

TgeneLIFR

GO:0019221

cytokine-mediated signaling pathway

7957045

TgeneLIFR

GO:0034097

response to cytokine

8999038

TgeneLIFR

GO:0048861

leukemia inhibitory factor signaling pathway

8999038|12643274

TgeneLIFR

GO:0070120

ciliary neurotrophic factor-mediated signaling pathway

12643274


check buttonFusion gene breakpoints across TRIO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LIFR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A44Q-06ATRIOchr5

14143991

-LIFRchr5

38489347

-
ChimerDB4SKCMTCGA-EB-A44Q-06ATRIOchr5

14143991

+LIFRchr5

38489347

-


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Fusion Gene ORF analysis for TRIO-LIFR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344204ENST00000503088TRIOchr5

14143991

+LIFRchr5

38489347

-
5CDS-intronENST00000537187ENST00000503088TRIOchr5

14143991

+LIFRchr5

38489347

-
In-frameENST00000344204ENST00000263409TRIOchr5

14143991

+LIFRchr5

38489347

-
In-frameENST00000344204ENST00000453190TRIOchr5

14143991

+LIFRchr5

38489347

-
In-frameENST00000537187ENST00000263409TRIOchr5

14143991

+LIFRchr5

38489347

-
In-frameENST00000537187ENST00000453190TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000344135ENST00000263409TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000344135ENST00000453190TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000509967ENST00000263409TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000509967ENST00000453190TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000515710ENST00000263409TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000515710ENST00000453190TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-intronENST00000344135ENST00000503088TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-intronENST00000509967ENST00000503088TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-intronENST00000515710ENST00000503088TRIOchr5

14143991

+LIFRchr5

38489347

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344204TRIOchr514143991+ENST00000263409LIFRchr538489347-7940181241307427
ENST00000344204TRIOchr514143991+ENST00000453190LIFRchr538489347-1935181241307427
ENST00000537187TRIOchr514143991+ENST00000263409LIFRchr538489347-792216361289427
ENST00000537187TRIOchr514143991+ENST00000453190LIFRchr538489347-191716361289427

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344204ENST00000263409TRIOchr514143991+LIFRchr538489347-7.24E-050.99992764
ENST00000344204ENST00000453190TRIOchr514143991+LIFRchr538489347-0.0001481460.9998518
ENST00000537187ENST00000263409TRIOchr514143991+LIFRchr538489347-7.32E-050.9999268
ENST00000537187ENST00000453190TRIOchr514143991+LIFRchr538489347-0.0001537260.9998462

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Fusion Genomic Features for TRIO-LIFR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIO-LIFR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:14143991/chr5:38489347)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

TRIOBP

LIFR

P42702

2365FUNCTION: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLIFRchr5:14143991chr5:38489347ENST000002634091420724_8337221098.0DomainFibronectin type-III 6
TgeneLIFRchr5:14143991chr5:38489347ENST000004531901420724_8337221098.0DomainFibronectin type-III 6
TgeneLIFRchr5:14143991chr5:38489347ENST000002634091420869_8777221098.0MotifNote=Box 1 motif
TgeneLIFRchr5:14143991chr5:38489347ENST000004531901420869_8777221098.0MotifNote=Box 1 motif
TgeneLIFRchr5:14143991chr5:38489347ENST000002634091420859_10977221098.0Topological domainCytoplasmic
TgeneLIFRchr5:14143991chr5:38489347ENST000004531901420859_10977221098.0Topological domainCytoplasmic
TgeneLIFRchr5:14143991chr5:38489347ENST000002634091420834_8587221098.0TransmembraneHelical
TgeneLIFRchr5:14143991chr5:38489347ENST000004531901420834_8587221098.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101845_18500597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102292_23120597.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102545_25510597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+110715_7180597.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571845_1850523098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572292_2312523098.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572545_2551523098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+157715_718523098.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581845_1850522922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582292_2312522922.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582545_2551522922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+158715_718522922.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101292_14670597.0DomainDH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101480_15910597.0DomainPH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101656_17210597.0DomainSH3 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101969_21450597.0DomainDH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102157_22710597.0DomainPH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102551_26160597.0DomainSH3 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102685_27750597.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102796_30520597.0DomainProtein kinase
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+11065_2100597.0DomainCRAL-TRIO
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571292_1467523098.0DomainDH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571480_1591523098.0DomainPH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571656_1721523098.0DomainSH3 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571969_2145523098.0DomainDH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572157_2271523098.0DomainPH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572551_2616523098.0DomainSH3 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572685_2775523098.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572796_3052523098.0DomainProtein kinase
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+15765_210523098.0DomainCRAL-TRIO
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581292_1467522922.0DomainDH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581480_1591522922.0DomainPH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581656_1721522922.0DomainSH3 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581969_2145522922.0DomainDH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582157_2271522922.0DomainPH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582551_2616522922.0DomainSH3 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582685_2775522922.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582796_3052522922.0DomainProtein kinase
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+15865_210522922.0DomainCRAL-TRIO
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102802_28100597.0Nucleotide bindingATP
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572802_2810523098.0Nucleotide bindingATP
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582802_2810522922.0Nucleotide bindingATP
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101109_12160597.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+110311_4180597.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+110538_6440597.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+110878_9840597.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571109_1216523098.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+157311_418523098.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+157538_644523098.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+157878_984523098.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581109_1216522922.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+158311_418522922.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+158538_644522922.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+158878_984522922.0RepeatNote=Spectrin 3
TgeneLIFRchr5:14143991chr5:38489347ENST000002634091420335_4347221098.0DomainFibronectin type-III 2
TgeneLIFRchr5:14143991chr5:38489347ENST000002634091420435_5347221098.0DomainFibronectin type-III 3
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409142049_1387221098.0DomainFibronectin type-III 1
TgeneLIFRchr5:14143991chr5:38489347ENST000002634091420538_6297221098.0DomainFibronectin type-III 4
TgeneLIFRchr5:14143991chr5:38489347ENST000002634091420627_7197221098.0DomainFibronectin type-III 5
TgeneLIFRchr5:14143991chr5:38489347ENST000004531901420335_4347221098.0DomainFibronectin type-III 2
TgeneLIFRchr5:14143991chr5:38489347ENST000004531901420435_5347221098.0DomainFibronectin type-III 3
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190142049_1387221098.0DomainFibronectin type-III 1
TgeneLIFRchr5:14143991chr5:38489347ENST000004531901420538_6297221098.0DomainFibronectin type-III 4
TgeneLIFRchr5:14143991chr5:38489347ENST000004531901420627_7197221098.0DomainFibronectin type-III 5
TgeneLIFRchr5:14143991chr5:38489347ENST000002634091420519_5237221098.0MotifNote=WSXWS motif
TgeneLIFRchr5:14143991chr5:38489347ENST000004531901420519_5237221098.0MotifNote=WSXWS motif
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409142045_8337221098.0Topological domainExtracellular
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190142045_8337221098.0Topological domainExtracellular


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Fusion Gene Sequence for TRIO-LIFR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94208_94208_1_TRIO-LIFR_TRIO_chr5_14143991_ENST00000344204_LIFR_chr5_38489347_ENST00000263409_length(transcript)=7940nt_BP=181nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GCTCCCATTGTTGCACCAAATTTTACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTT
AGAGGCTTTTTAAGAGGATATTTGTTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGAC
ATAAAAGTTAAGAATATTACTGACATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGA
GCCTATACAGATGGTGGAGTGGGCCCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATC
CCAGTGGCAGTGGCTGTCATTGTTGGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGAT
ATTCCAAATCCAGAAAACTGTAAAGCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCT
TGTACCCCAAATAATGTTGAGGTTCTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGT
CCTGAAGATCGCTCTGATGCAGAGCCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCC
GCAGATGAAGCTGGAGGGACTGCACAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAA
AATGACCCTGTAGGAGGGGCAGGCTATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTA
GATAAAACTGCGGGTTACAGACCTCAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGT
GAGATTGTCTCATTTGGAAGTCCATGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGA
GGAGGGTGGTCCTTTACAAACTTTTTTCAGAACAAACCAAACGATTAACAGTGTCACCGTGTCACTTCAGTCAGCCATCTCAATAAGCTC
TTACTGCTAGTGTTGCTACATCAGCACTGGGCATTCTTGGAGGGATCCTGTGAAGTATTGTTAGGAGGTGAACTTCACTACATGTTAAGT
TACACTGAAAGTGTTCATGTGCTTTTAATGTAGTCTAAAAGCCAAAGTATAGTGACTCAGAATCCTCAATCCACAAAACTCAAGATTGGG
AGCTCTTTGTGATCAAGCCAAAGAATTCTCATGTACTCTACCTTCAAGAAGCATTTCAAGGCTAATACCTACTTGTACGTACATGTAAAA
CAAATCCCGCCGCAACTGTTTTCTGTTCTGTTGTTTGTGGTTTTCTCATGTGTATACTTGGTGGAATTGTAAGTGGATTTGCAGGCCAGG
GAGAAAATGTCCAAGTAACAGGTGAAGTTTATTTGCCTGACGTTTACTCCTTTCTAGATGAAAACCAAGCACAGATTTTAAAACTTCTAA
GATTATTCTCCTCTATCCACAGCATTCACAAAAATTAATATAATTTTTAATGTAGTGACAGCGATTTAGTGTTTTGTTTGATAAAGTATG
CTTATTTCTGTGCCTACTGTATAATGGTTATCAAACAGTTGTCTCAGGGGTACAAACTTTGAAAACAAGTGTGACACTGACCAGCCCAAA
TCATAATCATGTTTTCTTGCTGTGATAGGTTTTGCAAGCCTTTTCATTATTTTTTAGCTTTTATGCTTGCTTCCATTATTTCAGTTGGTT
GCCCTAATATTTAAAATTTACACTTCTAAGACTAGAGACCCACATTTTTTAAAAATCATTTTATTTTGTGATACAGTGACAGCTTTATAT
GAGCAAATTCAATATTATTCATAAGCATGTAATTCCAGTGACTTACTATGTGAGATGACTACTAAGCAATATCTAGCAGCGTTAGCTGTC
CATATAGTTCTGATTGGATTTCGTTCCTCCTGAGGAGACCATGCCGTTGAGCTTGGCTACCCAGGCAGTGGTGATCTTTGACACCTTCTG
GTGGATGTTCCTCCCACTCATGAGTCTTTTCATCATGCCACATTATCTGATCCAGTCCTCACATTTTTAAATATAAAACTAAAGAGAGAA
TGCTTCTTACAGGAACAGTTACCCAAGGGCTGTTTCTTAGTAACTGTCATAAACTGATCTGAATCCATGGGCATACCTGTGTTGCAGGTG
CAGCAATTGCTTGGTGAGCTGTGCAGAATTGATTGCCTTCAGCACAGCATCCTCTGCCCACCCTTGTTTCTCATAAGCGATGTCTGGAGT
GATTGTGGTTCTTGGAAAAGCAGAAGGAAAAACTAAAAAGTGTATCTTGTATTTTCCCTGCCCTCAGGTTGCCTATGTATTTTACCTTTT
CATATTTAAGGCAAAAGTACTTGAAAATTTTAAGTGTCCGAATAAGATATGTCTTTTTTGTTTGTTTTTTTTGGTTGTTTGTTTGTTTTT
TATCATCTGAGATTCTGTAATGTATTTGCAAATAATGGATCAATTAATTTTTTTTGAAGCTCATATTGTATCTTTTTAAAAACCATGTTG
TGGAAAAAAGCCAGAGTGACAAGTGACAAAATCTATTTAGGTTCTCTGTGTATGAATCCTGATTTTAACTGCTAGGATTCAGCTAAATTT
CTGAGCTTTATGATCTGTGGAAATTTGGAATGAAATGCAATTCATTTTGTACATACATAGTATATTAAAACTATATAATAGTTCATAGAA
ATGTTCAGTAATGAAAAATATATCCAATCAGAGCCATCCCTAAAGAGTGTTCTCTTGTCTTCCTTTGTATCCTCTTTGGCTCCTTCCCTT
AGCTTCCACCCCAGACATCAGACCTGGGGCTGCCTTCTCTCCCTGCCAAAGCTTGCTGTTAGCATTGTCTGCTTGCCCTCAACTCCTGCC
TTGTTCCCTGTTGAAATGTATCAATCCCGTACTTTATCTCTCCAGGACAAGGATAAGTGTGGCTACAGTAAAAGTTTATTGCTCTAAACG
GCGCTAACCTGAGATAATGAGAAAAGGCCAGAAGAGATTGTTTGATCTCTGTCTGTCAATATATATGCATTTCAACTGTGACCATCTGGA
TCCAGGGCCCTTTCTAACCTATATAACGACTCATTTGTTTGGTTAATGATGAATATCACTGGGGCTCTTAAGTCCTTTCGTTCTATCCAA
GACTTCATTGTTTTTTTCTGTATGAAAAAAGTGCAGAATATCACTCACCTTTCCCCTACTTTTGGATCCCCTACACGAGGATCACTAGCT
TAATGAGAAGCAGAGTAACGCTATTAAGTCTGGGCAAGCTCCTTATAAGTTGCTGTGTGCTTAAAAGAATGTGATTTATGTCTGGGGCCA
AAGCAGTTTTCCTTCTTTTCCCTCATTGAATTCAAGACAGCTAGACCCTTGTGTAGATCCCAGGATATTACCTCTACTCCCCCCAACCTG
TGTGTGTAGGGAGAGTAACAACACGGGAAGAGGGGAGGGAAGTTGGAAGGAGATTGGTCACATGTTCAGTTGTCTGAGATACTGGTAAAT
GTGCGCTGTTTGTCAATGAAGGTTGCATGCCTGCATTTACAAGGTGGTCTCATACTGATTGTGCTCTGTCCAGTTAGATTCGTGGCTTCT
CCCTTGGAAGCTACAATTAAGGACTAGTTAGAAGCAGAGGCTAGATGTGTTCTCTCCAGCCCTTACTAACTGGGAAAATAATTGAGAAAT
CCCTCTTTTCCTCAGTGAAAGCCCAGTCATTGGTTAGAAAAATCTAATTGTCAAACTAGCATTATGTTCCATCATATCTGTGGGATAGTA
ATTCATGTAAGACACATTTTTACCTCTCTTACAAGTCAATTCACTTACAAGCCAGTTTCAAATCAAGCTTCCCTTGCGAGGAATGGAGAT
CATTATGGGGCTTATTATGACTACATTTCTTTTATGAGTGACCATTTTAAATAATTAATATTTTATTTAATATTAAATTATTAAAGACTT
AGCTAGACTTTTAACATTAGATGAACCTTGTGAATCATATATTGCATAGATTAGCACATGTATGCAATCTAGGTCATCAATTTGTTGAAT
TTATACAGCCCTAGATTTGAGATTGTGGCCCTGAGTATCTGGATAGTTGAGTTGTGTGTTTATGTGCTTATATGATAGAGGTGCTTTGTT
CCTGCAGCTTAGAAACAGAAGCAGCCATTCACTGAGAAGCTTAAGAGAGGAAGTATCAACCTCATTTTCCAAACCAGCATTACTTTCACC
GCTCGTGGATCTGAAAGATTACATTTAGAACATTTAGTACTATTACACTCTCAGAAACTGTGGTAAAAAGTCACATTTTCAAAACTTCAT
GCATATTGTATTCTTGTTGGAAATAAGTCCTATAGTTTCTTAATTGTCTTCATGCCGTCCATATTTAACAAACATTGCAAGTCCTTTTTA
TATTTGGGTAATTATTTGTAATTTAGTGAAGGAGACTAGGGGATGTTTTCTTCCAAAGGGAATTTAAAATCAATTTTATGGTATTTTGAA
AGTAAAATACTCCTTAACGTGTCAATATTTTTAAAATGTTATCTCGAAGTTTTCTATTGCTCAGGTATATAATCTAATAAAATTTTTTGT
TTGCTCTAAGGTTATTTTTGCTATTCTCTATTTTGAATTATGTTAAAATTTGTGTGCATTTTATGAAATGCCTTTTTTCTTATTTTGAAA
GTGTAAAATTGGGCATCTCAGAGTAAAATGTGGGATTATTAGCTACAAAGACTAGGCACATCGTGAAAGCTCAGTAACTAATTTTCTTGA
CTGAGTCCTATCCCAGAGTGTCACAGATTCAACAGAATTTTCCTGAAGGGTGATACACACCAAAATCTAGCTTGTGTGGATCTGAGACTA
TTGACTCAAAGATTCAAATCTACTTCGGAAGTGACTCCACGGTTTGAGTGAAAACTGAGGAAGGACTCATGCCTGTATATCACTAGATAT
CTTATTTCTCCATAATTTTAAGTGTTCATAATTTCTTCTTCTTTGATGGGTGTGCAACTGGGGCATGTTTGTACCAGCCAGCATGTGTTC
TGCCCAACAGTGTGTCCGTGTGTGAGGTTAACTGATTCAGAACTCATTCTCTTGATAAACTATTTCTTGAAAGCATTTATTTTAAGTCTT
TATTTCCTGCTGAAATGAAGTTTCATGCTGTCATGCCCATCTTATTTATTCTAGAAGAAAATTTTCATAGAAGAAAATGATTTATGGCCA
AAGTTACAGAACATTCATCTTTTAGACTTAGCCTTAGAATATCATTGGAAATTACTTGGCTTGAATTTGGTTCGTTTTTATCTTTATGGA
TTATGTACCAGGGCTATTAATAATACTTAAACCCCTTATTTTGCTATGGTGGTTAGATTTTTTTATTCCTTTTCAATTAGTGCTATTAAT
TATTACATGGTCGTATTCATGCTTATTACAGATGAACTATTTTTAGTGCCAGTGTAAAGGATTAAGAATAACATTCAATTAGTTGGCTAT
TTCAGGCTTTATTGTACATGGTAATGTTTCAGGGAGTGTGATTTGGTCTAGAATATATCCAGATCCTTGTAATTATGATATTGGGTTATG
ACAGGATTCTATTATTTTTAGCTATGAATGGTGCTTATTTTTCCCTATATTAGGAATGTTAATATTTGGATTATCAGAGTCCATGTTATA
AACAGAATTTACCTATGCAAGACAAATTCTAACTGTGCAACATTTTCATGAGAATTAAAAGTTGTGTGTTAAGGGGAAAACCCTCTGAAT
GTTTTTATGTGTAAGTGCCTAAAGAACCGTAGAAACAGTACATCAAAAGCTCTTATAAAAGAAAAACTGATTGAACATTAGCCAGAAACA
AAATATGATTTACATTTTTTTTTTTGGTTGCTGGGACTGAATACCCTAAAAACTAAGAGATGTGAGTGGGGAAAATGTCTAATTGATAAG
AAAGTTGATTTATATTATATTTACATGCATCTTCTAAGATTGCCTTTACAGTAGCCAATCAGAACTTTAAAAAAAAAAAAGCTAACAACA
TAGATCCTATGTGTTGCCCTTAAGACTAAAATACTTTGCACACGTGATTGAATGGCTCACTTAAGTTGTTGAATTTCCTTATACATTTAA
AGTGTACTTCCGTTAAGAATTATTCCATTTTAAATGGGTAACTTTCAGCTTCCGAACTATTTTCCTAAACATTCCAGTTGTGTATTATAA
AAGATCAAAATATCTCTAGGTGGTAGTACAATTTTCATTTATAACGTGGAAAAGTTAACTGTTAGGTTTAACATTAGTATTAGTGTTTTT
GCAATTGCTCATAGAAAAGAACACTGAATAATGGTTTTCATACAATTTTTGTAAAACATTCTTCTCCCAGTTTGATTCCAAATGCTTTTC
CCCAAATTGTCTAATATATCATAAGCTAGTGTTTCCTTGTATTTAATTTTTCCTTCCAACACAATATTTAGGAAAAATATGAATAACATT
GTGAGTAGCGGGAGACAACACGAAAAAGAAACCTTTCATTGTTGTGGAGGGGTAGGTGTTATGTGATTGATGCCCTTCCTGGCGTTTGTT
TTATCCTGTTATTTTCTCAAAAAAGAGCACGGCTTTTTCTTAAATACATTTAAATTCAGAATTGCTTGCAAAAGATTGGCCTGGATAGAT
AGACATCCTAGATTTAAGATAGTACCATCTTAAAAGTATGTTGAAAGGTAAAATAAATCATTTCAAAATACTTAACTTTCCTAATAAGGA
TGTTAGGTTTTCTTCTCTTTCATTAGCTGGCCATAAGTCAAGGTCCTTATAACACTAGGAAATTACCTTTTTTTACTTTCAAAATTGCAT
TATAGTGAATTACTGTTTACAAAATACACATACTGTGAACAGATATAAGTTTCTGTCTTTTATAAGGTTTGTAGAATGAATGTTTTTTTA
AAGTGAGTATTATATGTTAAATATTTTAAGTTTTTTATAAATACTAGTAACTGTTTACTAATTTTTGTTTGGTCAAATGCTTGTAAATGT
AGCTGAAAGAAGATAGGGAGAAACTGCGGATCCCAAACTGTTCCCTTTTTCATTTCTTGAAATGTTACCACTACAGACATTTTTTTAAGG
TGAATAAACAGTTGTGATGTGCTGTACCTAAAATCATGTTTAATCGTATAAGGAAACATTTCAATACACTTATACAGGAAGAAAACTATA
GATGAAGTACATGTGTGTGATTCAGTCTGATTCACAGAATTCTGAGAGTAATATGGAATAAAACAACTCCACTTAGATGATAACTGAAGC
ATTTCCTGCCTTGTGAAAATTTGGATTTTAAATTGCTGTTAGAATGGGAAATTTGGACACTTTATATCATTGTATAATTTCAGAATTTAG
TTTCTGTATCTTTTGGAAAACATGATTATAGCAAAAACATAGAAAATAATCTATTACTAAAACACCATAAATGTAAAACTAGTATGCTTG
GCTGTTAACTCTAAAGATGTTACTTATGTCTGTTTTTAAAACATGCATGTATTTAACAATTTTATCATAGTATTGTCATGGAAAAAATAA

>94208_94208_1_TRIO-LIFR_TRIO_chr5_14143991_ENST00000344204_LIFR_chr5_38489347_ENST00000263409_length(amino acids)=427AA_BP=52
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYL
FYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIV
GVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAE
PENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRP

--------------------------------------------------------------
>94208_94208_2_TRIO-LIFR_TRIO_chr5_14143991_ENST00000344204_LIFR_chr5_38489347_ENST00000453190_length(transcript)=1935nt_BP=181nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GCTCCCATTGTTGCACCAAATTTTACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTT
AGAGGCTTTTTAAGAGGATATTTGTTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGAC
ATAAAAGTTAAGAATATTACTGACATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGA
GCCTATACAGATGGTGGAGTGGGCCCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATC
CCAGTGGCAGTGGCTGTCATTGTTGGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGAT
ATTCCAAATCCAGAAAACTGTAAAGCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCT
TGTACCCCAAATAATGTTGAGGTTCTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGT
CCTGAAGATCGCTCTGATGCAGAGCCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCC
GCAGATGAAGCTGGAGGGACTGCACAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAA
AATGACCCTGTAGGAGGGGCAGGCTATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTA
GATAAAACTGCGGGTTACAGACCTCAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGT
GAGATTGTCTCATTTGGAAGTCCATGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGA
GGAGGGTGGTCCTTTACAAACTTTTTTCAGAACAAACCAAACGATTAACAGTGTCACCGTGTCACTTCAGTCAGCCATCTCAATAAGCTC
TTACTGCTAGTGTTGCTACATCAGCACTGGGCATTCTTGGAGGGATCCTGTGAAGTATTGTTAGGAGGTGAACTTCACTACATGTTAAGT
TACACTGAAAGTGTTCATGTGCTTTTAATGTAGTCTAAAAGCCAAAGTATAGTGACTCAGAATCCTCAATCCACAAAACTCAAGATTGGG
AGCTCTTTGTGATCAAGCCAAAGAATTCTCATGTACTCTACCTTCAAGAAGCATTTCAAGGCTAATACCTACTTGTACGTACATGTAAAA
CAAATCCCGCCGCAACTGTTTTCTGTTCTGTTGTTTGTGGTTTTCTCATGTGTATACTTGGTGGAATTGTAAGTGGATTTGCAGGCCAGG
GAGAAAATGTCCAAGTAACAGGTGAAGTTTATTTGCCTGACGTTTACTCCTTTCTAGATGAAAACCAAGCACAGATTTTAAAACTTCTAA
GATTATTCTCCTCTATCCACAGCATTCACAAAAATTAATATAATTTTTAATGTAGTGACAGCGATTTAGTGTTTTGTTTGATAAAGTATG

>94208_94208_2_TRIO-LIFR_TRIO_chr5_14143991_ENST00000344204_LIFR_chr5_38489347_ENST00000453190_length(amino acids)=427AA_BP=52
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYL
FYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIV
GVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAE
PENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRP

--------------------------------------------------------------
>94208_94208_3_TRIO-LIFR_TRIO_chr5_14143991_ENST00000537187_LIFR_chr5_38489347_ENST00000263409_length(transcript)=7922nt_BP=163nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGCTCCCATTGTTGCACCA
AATTTTACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTTAGAGGCTTTTTAAGAGGA
TATTTGTTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGACATAAAAGTTAAGAATATT
ACTGACATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGAGCCTATACAGATGGTGGA
GTGGGCCCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATCCCAGTGGCAGTGGCTGTC
ATTGTTGGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGATATTCCAAATCCAGAAAAC
TGTAAAGCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCTTGTACCCCAAATAATGTT
GAGGTTCTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGTCCTGAAGATCGCTCTGAT
GCAGAGCCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCCGCAGATGAAGCTGGAGGG
ACTGCACAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAAAATGACCCTGTAGGAGGG
GCAGGCTATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTAGATAAAACTGCGGGTTAC
AGACCTCAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGTGAGATTGTCTCATTTGGA
AGTCCATGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGAGGAGGGTGGTCCTTTACA
AACTTTTTTCAGAACAAACCAAACGATTAACAGTGTCACCGTGTCACTTCAGTCAGCCATCTCAATAAGCTCTTACTGCTAGTGTTGCTA
CATCAGCACTGGGCATTCTTGGAGGGATCCTGTGAAGTATTGTTAGGAGGTGAACTTCACTACATGTTAAGTTACACTGAAAGTGTTCAT
GTGCTTTTAATGTAGTCTAAAAGCCAAAGTATAGTGACTCAGAATCCTCAATCCACAAAACTCAAGATTGGGAGCTCTTTGTGATCAAGC
CAAAGAATTCTCATGTACTCTACCTTCAAGAAGCATTTCAAGGCTAATACCTACTTGTACGTACATGTAAAACAAATCCCGCCGCAACTG
TTTTCTGTTCTGTTGTTTGTGGTTTTCTCATGTGTATACTTGGTGGAATTGTAAGTGGATTTGCAGGCCAGGGAGAAAATGTCCAAGTAA
CAGGTGAAGTTTATTTGCCTGACGTTTACTCCTTTCTAGATGAAAACCAAGCACAGATTTTAAAACTTCTAAGATTATTCTCCTCTATCC
ACAGCATTCACAAAAATTAATATAATTTTTAATGTAGTGACAGCGATTTAGTGTTTTGTTTGATAAAGTATGCTTATTTCTGTGCCTACT
GTATAATGGTTATCAAACAGTTGTCTCAGGGGTACAAACTTTGAAAACAAGTGTGACACTGACCAGCCCAAATCATAATCATGTTTTCTT
GCTGTGATAGGTTTTGCAAGCCTTTTCATTATTTTTTAGCTTTTATGCTTGCTTCCATTATTTCAGTTGGTTGCCCTAATATTTAAAATT
TACACTTCTAAGACTAGAGACCCACATTTTTTAAAAATCATTTTATTTTGTGATACAGTGACAGCTTTATATGAGCAAATTCAATATTAT
TCATAAGCATGTAATTCCAGTGACTTACTATGTGAGATGACTACTAAGCAATATCTAGCAGCGTTAGCTGTCCATATAGTTCTGATTGGA
TTTCGTTCCTCCTGAGGAGACCATGCCGTTGAGCTTGGCTACCCAGGCAGTGGTGATCTTTGACACCTTCTGGTGGATGTTCCTCCCACT
CATGAGTCTTTTCATCATGCCACATTATCTGATCCAGTCCTCACATTTTTAAATATAAAACTAAAGAGAGAATGCTTCTTACAGGAACAG
TTACCCAAGGGCTGTTTCTTAGTAACTGTCATAAACTGATCTGAATCCATGGGCATACCTGTGTTGCAGGTGCAGCAATTGCTTGGTGAG
CTGTGCAGAATTGATTGCCTTCAGCACAGCATCCTCTGCCCACCCTTGTTTCTCATAAGCGATGTCTGGAGTGATTGTGGTTCTTGGAAA
AGCAGAAGGAAAAACTAAAAAGTGTATCTTGTATTTTCCCTGCCCTCAGGTTGCCTATGTATTTTACCTTTTCATATTTAAGGCAAAAGT
ACTTGAAAATTTTAAGTGTCCGAATAAGATATGTCTTTTTTGTTTGTTTTTTTTGGTTGTTTGTTTGTTTTTTATCATCTGAGATTCTGT
AATGTATTTGCAAATAATGGATCAATTAATTTTTTTTGAAGCTCATATTGTATCTTTTTAAAAACCATGTTGTGGAAAAAAGCCAGAGTG
ACAAGTGACAAAATCTATTTAGGTTCTCTGTGTATGAATCCTGATTTTAACTGCTAGGATTCAGCTAAATTTCTGAGCTTTATGATCTGT
GGAAATTTGGAATGAAATGCAATTCATTTTGTACATACATAGTATATTAAAACTATATAATAGTTCATAGAAATGTTCAGTAATGAAAAA
TATATCCAATCAGAGCCATCCCTAAAGAGTGTTCTCTTGTCTTCCTTTGTATCCTCTTTGGCTCCTTCCCTTAGCTTCCACCCCAGACAT
CAGACCTGGGGCTGCCTTCTCTCCCTGCCAAAGCTTGCTGTTAGCATTGTCTGCTTGCCCTCAACTCCTGCCTTGTTCCCTGTTGAAATG
TATCAATCCCGTACTTTATCTCTCCAGGACAAGGATAAGTGTGGCTACAGTAAAAGTTTATTGCTCTAAACGGCGCTAACCTGAGATAAT
GAGAAAAGGCCAGAAGAGATTGTTTGATCTCTGTCTGTCAATATATATGCATTTCAACTGTGACCATCTGGATCCAGGGCCCTTTCTAAC
CTATATAACGACTCATTTGTTTGGTTAATGATGAATATCACTGGGGCTCTTAAGTCCTTTCGTTCTATCCAAGACTTCATTGTTTTTTTC
TGTATGAAAAAAGTGCAGAATATCACTCACCTTTCCCCTACTTTTGGATCCCCTACACGAGGATCACTAGCTTAATGAGAAGCAGAGTAA
CGCTATTAAGTCTGGGCAAGCTCCTTATAAGTTGCTGTGTGCTTAAAAGAATGTGATTTATGTCTGGGGCCAAAGCAGTTTTCCTTCTTT
TCCCTCATTGAATTCAAGACAGCTAGACCCTTGTGTAGATCCCAGGATATTACCTCTACTCCCCCCAACCTGTGTGTGTAGGGAGAGTAA
CAACACGGGAAGAGGGGAGGGAAGTTGGAAGGAGATTGGTCACATGTTCAGTTGTCTGAGATACTGGTAAATGTGCGCTGTTTGTCAATG
AAGGTTGCATGCCTGCATTTACAAGGTGGTCTCATACTGATTGTGCTCTGTCCAGTTAGATTCGTGGCTTCTCCCTTGGAAGCTACAATT
AAGGACTAGTTAGAAGCAGAGGCTAGATGTGTTCTCTCCAGCCCTTACTAACTGGGAAAATAATTGAGAAATCCCTCTTTTCCTCAGTGA
AAGCCCAGTCATTGGTTAGAAAAATCTAATTGTCAAACTAGCATTATGTTCCATCATATCTGTGGGATAGTAATTCATGTAAGACACATT
TTTACCTCTCTTACAAGTCAATTCACTTACAAGCCAGTTTCAAATCAAGCTTCCCTTGCGAGGAATGGAGATCATTATGGGGCTTATTAT
GACTACATTTCTTTTATGAGTGACCATTTTAAATAATTAATATTTTATTTAATATTAAATTATTAAAGACTTAGCTAGACTTTTAACATT
AGATGAACCTTGTGAATCATATATTGCATAGATTAGCACATGTATGCAATCTAGGTCATCAATTTGTTGAATTTATACAGCCCTAGATTT
GAGATTGTGGCCCTGAGTATCTGGATAGTTGAGTTGTGTGTTTATGTGCTTATATGATAGAGGTGCTTTGTTCCTGCAGCTTAGAAACAG
AAGCAGCCATTCACTGAGAAGCTTAAGAGAGGAAGTATCAACCTCATTTTCCAAACCAGCATTACTTTCACCGCTCGTGGATCTGAAAGA
TTACATTTAGAACATTTAGTACTATTACACTCTCAGAAACTGTGGTAAAAAGTCACATTTTCAAAACTTCATGCATATTGTATTCTTGTT
GGAAATAAGTCCTATAGTTTCTTAATTGTCTTCATGCCGTCCATATTTAACAAACATTGCAAGTCCTTTTTATATTTGGGTAATTATTTG
TAATTTAGTGAAGGAGACTAGGGGATGTTTTCTTCCAAAGGGAATTTAAAATCAATTTTATGGTATTTTGAAAGTAAAATACTCCTTAAC
GTGTCAATATTTTTAAAATGTTATCTCGAAGTTTTCTATTGCTCAGGTATATAATCTAATAAAATTTTTTGTTTGCTCTAAGGTTATTTT
TGCTATTCTCTATTTTGAATTATGTTAAAATTTGTGTGCATTTTATGAAATGCCTTTTTTCTTATTTTGAAAGTGTAAAATTGGGCATCT
CAGAGTAAAATGTGGGATTATTAGCTACAAAGACTAGGCACATCGTGAAAGCTCAGTAACTAATTTTCTTGACTGAGTCCTATCCCAGAG
TGTCACAGATTCAACAGAATTTTCCTGAAGGGTGATACACACCAAAATCTAGCTTGTGTGGATCTGAGACTATTGACTCAAAGATTCAAA
TCTACTTCGGAAGTGACTCCACGGTTTGAGTGAAAACTGAGGAAGGACTCATGCCTGTATATCACTAGATATCTTATTTCTCCATAATTT
TAAGTGTTCATAATTTCTTCTTCTTTGATGGGTGTGCAACTGGGGCATGTTTGTACCAGCCAGCATGTGTTCTGCCCAACAGTGTGTCCG
TGTGTGAGGTTAACTGATTCAGAACTCATTCTCTTGATAAACTATTTCTTGAAAGCATTTATTTTAAGTCTTTATTTCCTGCTGAAATGA
AGTTTCATGCTGTCATGCCCATCTTATTTATTCTAGAAGAAAATTTTCATAGAAGAAAATGATTTATGGCCAAAGTTACAGAACATTCAT
CTTTTAGACTTAGCCTTAGAATATCATTGGAAATTACTTGGCTTGAATTTGGTTCGTTTTTATCTTTATGGATTATGTACCAGGGCTATT
AATAATACTTAAACCCCTTATTTTGCTATGGTGGTTAGATTTTTTTATTCCTTTTCAATTAGTGCTATTAATTATTACATGGTCGTATTC
ATGCTTATTACAGATGAACTATTTTTAGTGCCAGTGTAAAGGATTAAGAATAACATTCAATTAGTTGGCTATTTCAGGCTTTATTGTACA
TGGTAATGTTTCAGGGAGTGTGATTTGGTCTAGAATATATCCAGATCCTTGTAATTATGATATTGGGTTATGACAGGATTCTATTATTTT
TAGCTATGAATGGTGCTTATTTTTCCCTATATTAGGAATGTTAATATTTGGATTATCAGAGTCCATGTTATAAACAGAATTTACCTATGC
AAGACAAATTCTAACTGTGCAACATTTTCATGAGAATTAAAAGTTGTGTGTTAAGGGGAAAACCCTCTGAATGTTTTTATGTGTAAGTGC
CTAAAGAACCGTAGAAACAGTACATCAAAAGCTCTTATAAAAGAAAAACTGATTGAACATTAGCCAGAAACAAAATATGATTTACATTTT
TTTTTTTGGTTGCTGGGACTGAATACCCTAAAAACTAAGAGATGTGAGTGGGGAAAATGTCTAATTGATAAGAAAGTTGATTTATATTAT
ATTTACATGCATCTTCTAAGATTGCCTTTACAGTAGCCAATCAGAACTTTAAAAAAAAAAAAGCTAACAACATAGATCCTATGTGTTGCC
CTTAAGACTAAAATACTTTGCACACGTGATTGAATGGCTCACTTAAGTTGTTGAATTTCCTTATACATTTAAAGTGTACTTCCGTTAAGA
ATTATTCCATTTTAAATGGGTAACTTTCAGCTTCCGAACTATTTTCCTAAACATTCCAGTTGTGTATTATAAAAGATCAAAATATCTCTA
GGTGGTAGTACAATTTTCATTTATAACGTGGAAAAGTTAACTGTTAGGTTTAACATTAGTATTAGTGTTTTTGCAATTGCTCATAGAAAA
GAACACTGAATAATGGTTTTCATACAATTTTTGTAAAACATTCTTCTCCCAGTTTGATTCCAAATGCTTTTCCCCAAATTGTCTAATATA
TCATAAGCTAGTGTTTCCTTGTATTTAATTTTTCCTTCCAACACAATATTTAGGAAAAATATGAATAACATTGTGAGTAGCGGGAGACAA
CACGAAAAAGAAACCTTTCATTGTTGTGGAGGGGTAGGTGTTATGTGATTGATGCCCTTCCTGGCGTTTGTTTTATCCTGTTATTTTCTC
AAAAAAGAGCACGGCTTTTTCTTAAATACATTTAAATTCAGAATTGCTTGCAAAAGATTGGCCTGGATAGATAGACATCCTAGATTTAAG
ATAGTACCATCTTAAAAGTATGTTGAAAGGTAAAATAAATCATTTCAAAATACTTAACTTTCCTAATAAGGATGTTAGGTTTTCTTCTCT
TTCATTAGCTGGCCATAAGTCAAGGTCCTTATAACACTAGGAAATTACCTTTTTTTACTTTCAAAATTGCATTATAGTGAATTACTGTTT
ACAAAATACACATACTGTGAACAGATATAAGTTTCTGTCTTTTATAAGGTTTGTAGAATGAATGTTTTTTTAAAGTGAGTATTATATGTT
AAATATTTTAAGTTTTTTATAAATACTAGTAACTGTTTACTAATTTTTGTTTGGTCAAATGCTTGTAAATGTAGCTGAAAGAAGATAGGG
AGAAACTGCGGATCCCAAACTGTTCCCTTTTTCATTTCTTGAAATGTTACCACTACAGACATTTTTTTAAGGTGAATAAACAGTTGTGAT
GTGCTGTACCTAAAATCATGTTTAATCGTATAAGGAAACATTTCAATACACTTATACAGGAAGAAAACTATAGATGAAGTACATGTGTGT
GATTCAGTCTGATTCACAGAATTCTGAGAGTAATATGGAATAAAACAACTCCACTTAGATGATAACTGAAGCATTTCCTGCCTTGTGAAA
ATTTGGATTTTAAATTGCTGTTAGAATGGGAAATTTGGACACTTTATATCATTGTATAATTTCAGAATTTAGTTTCTGTATCTTTTGGAA
AACATGATTATAGCAAAAACATAGAAAATAATCTATTACTAAAACACCATAAATGTAAAACTAGTATGCTTGGCTGTTAACTCTAAAGAT
GTTACTTATGTCTGTTTTTAAAACATGCATGTATTTAACAATTTTATCATAGTATTGTCATGGAAAAAATAAATATATTTTCTTACATCT

>94208_94208_3_TRIO-LIFR_TRIO_chr5_14143991_ENST00000537187_LIFR_chr5_38489347_ENST00000263409_length(amino acids)=427AA_BP=52
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYL
FYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIV
GVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAE
PENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRP

--------------------------------------------------------------
>94208_94208_4_TRIO-LIFR_TRIO_chr5_14143991_ENST00000537187_LIFR_chr5_38489347_ENST00000453190_length(transcript)=1917nt_BP=163nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGCTCCCATTGTTGCACCA
AATTTTACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTTAGAGGCTTTTTAAGAGGA
TATTTGTTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGACATAAAAGTTAAGAATATT
ACTGACATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGAGCCTATACAGATGGTGGA
GTGGGCCCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATCCCAGTGGCAGTGGCTGTC
ATTGTTGGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGATATTCCAAATCCAGAAAAC
TGTAAAGCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCTTGTACCCCAAATAATGTT
GAGGTTCTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGTCCTGAAGATCGCTCTGAT
GCAGAGCCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCCGCAGATGAAGCTGGAGGG
ACTGCACAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAAAATGACCCTGTAGGAGGG
GCAGGCTATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTAGATAAAACTGCGGGTTAC
AGACCTCAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGTGAGATTGTCTCATTTGGA
AGTCCATGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGAGGAGGGTGGTCCTTTACA
AACTTTTTTCAGAACAAACCAAACGATTAACAGTGTCACCGTGTCACTTCAGTCAGCCATCTCAATAAGCTCTTACTGCTAGTGTTGCTA
CATCAGCACTGGGCATTCTTGGAGGGATCCTGTGAAGTATTGTTAGGAGGTGAACTTCACTACATGTTAAGTTACACTGAAAGTGTTCAT
GTGCTTTTAATGTAGTCTAAAAGCCAAAGTATAGTGACTCAGAATCCTCAATCCACAAAACTCAAGATTGGGAGCTCTTTGTGATCAAGC
CAAAGAATTCTCATGTACTCTACCTTCAAGAAGCATTTCAAGGCTAATACCTACTTGTACGTACATGTAAAACAAATCCCGCCGCAACTG
TTTTCTGTTCTGTTGTTTGTGGTTTTCTCATGTGTATACTTGGTGGAATTGTAAGTGGATTTGCAGGCCAGGGAGAAAATGTCCAAGTAA
CAGGTGAAGTTTATTTGCCTGACGTTTACTCCTTTCTAGATGAAAACCAAGCACAGATTTTAAAACTTCTAAGATTATTCTCCTCTATCC
ACAGCATTCACAAAAATTAATATAATTTTTAATGTAGTGACAGCGATTTAGTGTTTTGTTTGATAAAGTATGCTTATTTCTGTGCCTACT

>94208_94208_4_TRIO-LIFR_TRIO_chr5_14143991_ENST00000537187_LIFR_chr5_38489347_ENST00000453190_length(amino acids)=427AA_BP=52
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYL
FYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIV
GVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAE
PENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRP

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Fusion Gene PPI Analysis for TRIO-LIFR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIO-LIFR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIO-LIFR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource