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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIO-MOV10 (FusionGDB2 ID:94213)

Fusion Gene Summary for TRIO-MOV10

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO-MOV10
Fusion gene ID: 94213
HgeneTgene
Gene symbol

TRIO

MOV10

Gene ID

7204

4343

Gene nametrio Rho guanine nucleotide exchange factorMov10 RISC complex RNA helicase
SynonymsARHGEF23|MEBAS|MRD44|tgatfSAP113|gb110
Cytomap

5p15.2

1p13.2

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)helicase MOV-10Mov10, Moloney leukemia virus 10, homologarmitage homologfunctional spliceosome-associated protein 113moloney leukemia virus 10 proteinputative helicase MOV-10
Modification date2020031320200320
UniProtAcc

TRIOBP

Q9BXT6

Ensembl transtripts involved in fusion geneENST00000344204, ENST00000509967, 
ENST00000537187, ENST00000344135, 
ENST00000515710, 		ENST00000468624, 
ENST00000357443, ENST00000369644, 
ENST00000369645, ENST00000413052, 
ENST00000544796, 
Fusion gene scores* DoF score34 X 28 X 12=114246 X 6 X 2=72
# samples 356
** MAII scorelog2(35/11424*10)=-5.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIO [Title/Abstract] AND MOV10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIO(14369500)-MOV10(113241269), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMOV10

GO:0010526

negative regulation of transposition, RNA-mediated

23093941|30122351

TgeneMOV10

GO:0035279

mRNA cleavage involved in gene silencing by miRNA

16289642

TgeneMOV10

GO:0061014

positive regulation of mRNA catabolic process

24726324

TgeneMOV10

GO:0061158

3'-UTR-mediated mRNA destabilization

24726324


check buttonFusion gene breakpoints across TRIO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MOV10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF926051TRIOchr5

14369500

-MOV10chr1

113241269

+


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Fusion Gene ORF analysis for TRIO-MOV10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000344204ENST00000468624TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-3UTRENST00000509967ENST00000468624TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-3UTRENST00000537187ENST00000468624TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000344204ENST00000357443TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000344204ENST00000369644TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000344204ENST00000369645TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000344204ENST00000413052TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000344204ENST00000544796TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000509967ENST00000357443TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000509967ENST00000369644TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000509967ENST00000369645TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000509967ENST00000413052TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000509967ENST00000544796TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000537187ENST00000357443TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000537187ENST00000369644TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000537187ENST00000369645TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000537187ENST00000413052TRIOchr5

14369500

-MOV10chr1

113241269

+
5CDS-intronENST00000537187ENST00000544796TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-3UTRENST00000344135ENST00000468624TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-3UTRENST00000515710ENST00000468624TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-intronENST00000344135ENST00000357443TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-intronENST00000344135ENST00000369644TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-intronENST00000344135ENST00000369645TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-intronENST00000344135ENST00000413052TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-intronENST00000344135ENST00000544796TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-intronENST00000515710ENST00000357443TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-intronENST00000515710ENST00000369644TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-intronENST00000515710ENST00000369645TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-intronENST00000515710ENST00000413052TRIOchr5

14369500

-MOV10chr1

113241269

+
intron-intronENST00000515710ENST00000544796TRIOchr5

14369500

-MOV10chr1

113241269

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TRIO-MOV10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIO-MOV10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:14369500/:113241269)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

TRIOBP

MOV10

Q9BXT6

2365FUNCTION: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. {ECO:0000250|UniProtKB:Q99MV5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TRIO-MOV10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TRIO-MOV10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIO-MOV10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIO-MOV10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource