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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIO-PPP2R5E (FusionGDB2 ID:94214)

Fusion Gene Summary for TRIO-PPP2R5E

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO-PPP2R5E
Fusion gene ID: 94214
HgeneTgene
Gene symbol

TRIO

PPP2R5E

Gene ID

7204

5529

Gene nametrio Rho guanine nucleotide exchange factorprotein phosphatase 2 regulatory subunit B'epsilon
SynonymsARHGEF23|MEBAS|MRD44|tgatB56E|B56epsilon
Cytomap

5p15.2

14q23.2

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoformPP2A, B subunit, B' epsilonPP2A, B subunit, B56 epsilonPP2A, B subunit, PR61 epsilonPP2A, B subunit, R5 epsilonepsilon isoform of regulatory subunit B56, protein phospha
Modification date2020031320200320
UniProtAcc

TRIOBP

.
Ensembl transtripts involved in fusion geneENST00000344204, ENST00000509967, 
ENST00000537187, ENST00000344135, 
ENST00000515710, 
ENST00000553266, 
ENST00000337537, ENST00000422769, 
ENST00000555899, 
Fusion gene scores* DoF score34 X 28 X 12=1142416 X 15 X 5=1200
# samples 3516
** MAII scorelog2(35/11424*10)=-5.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/1200*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIO [Title/Abstract] AND PPP2R5E [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIO(14280545)-PPP2R5E(63848875), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRIO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP2R5E (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BA-5153-01ATRIOchr5

14280545

-PPP2R5Echr14

63848875

-
ChimerDB4HNSCTCGA-BA-5153-01ATRIOchr5

14280545

+PPP2R5Echr14

63848875

-
ChimerDB4HNSCTCGA-BA-5153TRIOchr5

14280545

+PPP2R5Echr14

63848875

-


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Fusion Gene ORF analysis for TRIO-PPP2R5E

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000344204ENST00000553266TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
5CDS-5UTRENST00000509967ENST00000553266TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
5CDS-5UTRENST00000537187ENST00000553266TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
In-frameENST00000344204ENST00000337537TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
In-frameENST00000344204ENST00000422769TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
In-frameENST00000344204ENST00000555899TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
In-frameENST00000509967ENST00000337537TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
In-frameENST00000509967ENST00000422769TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
In-frameENST00000509967ENST00000555899TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
In-frameENST00000537187ENST00000337537TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
In-frameENST00000537187ENST00000422769TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
In-frameENST00000537187ENST00000555899TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
intron-3CDSENST00000344135ENST00000337537TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
intron-3CDSENST00000344135ENST00000422769TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
intron-3CDSENST00000344135ENST00000555899TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
intron-3CDSENST00000515710ENST00000337537TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
intron-3CDSENST00000515710ENST00000422769TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
intron-3CDSENST00000515710ENST00000555899TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
intron-5UTRENST00000344135ENST00000553266TRIOchr5

14280545

+PPP2R5Echr14

63848875

-
intron-5UTRENST00000515710ENST00000553266TRIOchr5

14280545

+PPP2R5Echr14

63848875

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000344204TRIOchr514280545+ENST00000337537PPP2R5Echr1463848875-522537124572182
ENST00000344204TRIOchr514280545+ENST00000555899PPP2R5Echr1463848875-80637124557177
ENST00000344204TRIOchr514280545+ENST00000422769PPP2R5Echr1463848875-72937124572182
ENST00000537187TRIOchr514280545+ENST00000337537PPP2R5Echr1463848875-52073536554182
ENST00000537187TRIOchr514280545+ENST00000555899PPP2R5Echr1463848875-7883536539177
ENST00000537187TRIOchr514280545+ENST00000422769PPP2R5Echr1463848875-7113536554182
ENST00000509967TRIOchr514280545+ENST00000337537PPP2R5Echr1463848875-5206352152553133
ENST00000509967TRIOchr514280545+ENST00000555899PPP2R5Echr1463848875-787352152538128
ENST00000509967TRIOchr514280545+ENST00000422769PPP2R5Echr1463848875-710352152553133

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344204ENST00000337537TRIOchr514280545+PPP2R5Echr1463848875-0.0004323950.99956757
ENST00000344204ENST00000555899TRIOchr514280545+PPP2R5Echr1463848875-0.0010694950.9989305
ENST00000344204ENST00000422769TRIOchr514280545+PPP2R5Echr1463848875-0.0013426580.99865735
ENST00000537187ENST00000337537TRIOchr514280545+PPP2R5Echr1463848875-0.0004433570.9995566
ENST00000537187ENST00000555899TRIOchr514280545+PPP2R5Echr1463848875-0.0008924550.99910754
ENST00000537187ENST00000422769TRIOchr514280545+PPP2R5Echr1463848875-0.0011912740.99880874
ENST00000509967ENST00000337537TRIOchr514280545+PPP2R5Echr1463848875-0.0056864030.9943136
ENST00000509967ENST00000555899TRIOchr514280545+PPP2R5Echr1463848875-0.0126828880.98731714
ENST00000509967ENST00000422769TRIOchr514280545+PPP2R5Echr1463848875-0.0288499910.97115

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Fusion Genomic Features for TRIO-PPP2R5E


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIO-PPP2R5E


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:14280545/chr14:63848875)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

TRIOBP

.
2365FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1101845_18500597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1102292_23120597.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1102545_25510597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+110715_7180597.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3571845_18501153098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3572292_23121153098.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3572545_25511153098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+357715_7181153098.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3581845_18501152922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3582292_23121152922.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3582545_25511152922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+358715_7181152922.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1101292_14670597.0DomainDH 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1101480_15910597.0DomainPH 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1101656_17210597.0DomainSH3 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1101969_21450597.0DomainDH 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1102157_22710597.0DomainPH 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1102551_26160597.0DomainSH3 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1102685_27750597.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1102796_30520597.0DomainProtein kinase
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+11065_2100597.0DomainCRAL-TRIO
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3571292_14671153098.0DomainDH 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3571480_15911153098.0DomainPH 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3571656_17211153098.0DomainSH3 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3571969_21451153098.0DomainDH 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3572157_22711153098.0DomainPH 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3572551_26161153098.0DomainSH3 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3572685_27751153098.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3572796_30521153098.0DomainProtein kinase
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+35765_2101153098.0DomainCRAL-TRIO
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3581292_14671152922.0DomainDH 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3581480_15911152922.0DomainPH 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3581656_17211152922.0DomainSH3 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3581969_21451152922.0DomainDH 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3582157_22711152922.0DomainPH 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3582551_26161152922.0DomainSH3 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3582685_27751152922.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3582796_30521152922.0DomainProtein kinase
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+35865_2101152922.0DomainCRAL-TRIO
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1102802_28100597.0Nucleotide bindingATP
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3572802_28101153098.0Nucleotide bindingATP
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3582802_28101152922.0Nucleotide bindingATP
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+1101109_12160597.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+110311_4180597.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+110538_6440597.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000344135+110878_9840597.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+3571109_12161153098.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+357311_4181153098.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+357538_6441153098.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000344204+357878_9841153098.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+3581109_12161152922.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+358311_4181152922.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+358538_6441152922.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14280545chr14:63848875ENST00000537187+358878_9841152922.0RepeatNote=Spectrin 3


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Fusion Gene Sequence for TRIO-PPP2R5E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94214_94214_1_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000344204_PPP2R5E_chr14_63848875_ENST00000337537_length(transcript)=5225nt_BP=371nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGGGCTATTGTGGCGTTGGTGTACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCC
ACATACAAGTCAGATCGTCAGCGTGAGAAAAAGAAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGA
GGTCTTAGACGTGATGGAATAATTCCAACTTAACAAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAA
GATGGAGCAACAGTTTTCTGTATTGTGCAACTTTACAGTAGATTTCACCTTTGTTTCATTATTACAGCAGCACTGTATATACCTGTCTCT
AAGTAAAGGAAAAAACAAAATAAGGACTTCAATCCAAAGTTTGGACAGTAGATGGACTTCTCAGAACTTTGCAAACATAATCATTGTTCT
CACCCTCTTTTAAAAAAAAAAATCGGTCTTCAAAGATCTGTTGATGAAATTGCTATGTTAAAATTCCATTATCGGGAGTTCCTTATTTAT
CACTAGCAGAGAGTATGATACAATTTTCAAATGTGAACAATCTTAAATTTAGCTTGTCTTTCTGCTAAGCTGTTAAATGTATTTATAGTA
AAGGAAGAAAAAAAGACTGTCATTTCCTTATAAGTTTGTGTAACATCCTCCTCTGGATAACTTGACTGTAATTTAACATCTTTTTCTTTT
GCACATCTTCCTGAGTTGAATGTCCACGTGGAATGGGGTCATGAATTATAAAAGTCCCTGATAAAAGTTTTGTTTACTGGGGTGAACATC
TTTCCAGTAACCAGGTAGTCCTGGTACTCCTTTAGTTTTAAAATTAGGAGTTAAGAGAGAAGAGGTGATAAACATAGTAGGGAAGGGAAT
ATCGGATTCATGCATCAGTTTATGGTGAATCCAAATCAATGTCTTGAATCCTTTGAAAACAGGCACTGGGACATCACAGGCTTCAGTACC
TGACCAGTATTAGTTGCATATATCATTGAACACACATACCAGAGATGTTTTAGAAATGTGAGAAAAACATCCTTTTGGACCATTTGAAAT
AAGAAAGACAAACACTAAACAATACAACCATGAAATTGATCACCGGGATTGCAAATCTAATTGGGAAAAGAGTTGAGCAAACAGCTTGGA
CTGTTTGGAGTTGTTGCCTTACTTTTTAATATGTATTTATAAAGTATTCCAGCAAAAGAGGATGTAGCCTCTGGGAAAAAACAAACATGT
TACAGTGTTTTTTGTAGATTCTCGTTCTATATCTCATCACAGCGCCAGCCCTGTTTTTAGCCGGAAAGGATTCAGGATAAACATTATTAT
GCATTCTGAATTGGATGCATATTCCTAACTACTGTATTTGTTACCAAAAGTGGTTCTACAAATGCTACTGAAAAAAATCTGGAAATTCCT
AATGTCCTGAGTATTAATAATAAAGTTTAAAAATGCTTTTATATCAAAGGTGCATCGTGACCAAATTGTTTAAGAAAAAAAAACAAAAAA
AACAAAATCTAGGGCTGTATTTTATATATATATATATATATATATATATATATATATCTTATTGGCTCTCTGCTTTGTATTTAAATGAAG
AATCTTACATCTTGGGTAGGTAAACTGCTGATAAAATTTGTGTACAGTATGTACTTACCTAATGCAGTTGCATTATTACGTACTGAAAGA
TATGTGTTTGGAGGTTTATTTCCAGGATGCATTTGCTTGTTTTGGTCATGGCAGCAGTGAGTTGGTAATCCTAAACCATCACTTCCAGCA
GTATTCATGGTATAGAGCTGATCTGTGTTCATATGTTGAATTGTGATAGTAGCAAACATGAACATATGAACTATTGTTGCTCTTAATAGA
AATACAATATAAATATGGGCTTGTATATTTTCTTCCTTACATTTAAATATAAAGTAGAATACGCAGTTTTATTATTTTCAAGAAAAAGAA
AGAGAAGCTGCTGACCTTTCTCCCCCATAAAGTTTTTCAGGATGATCAGGTCACAGTGTGTACGTAAGAGTCAGCTAATTATGGATATTG
TCATCTCGGTAACTTTGTAAAAAAACAAACAAAACTGGCATTGTTAATTCCAAAAAGAAAAAAAAAAGCAGTAAAAAAAAAAAGTCATAT
GCAACACCAGACGCAACATGGTTTAATGGAATTAATAGTTTTTTTTTTTTTTTTTTTAAAGAACATTGATGGGGATTCACTGTAAAGTTG
GCAGAGGCTGCCAAAGACGAAACAACTGACTTTAAAAATGCTGGAACAATGTGATAAAAAATAAATTTGTAACAAATCTTCTCCTTTTTA
GCCCTTGTCATTTTAGCCCTTTAGTTTCAACTCTGCATTATATTTAGTTTATATAGTGTAAACTTTTGTTTGCCATTAATTCATCTTTTT
AGGTAGAAGACATTAAAATCACAGGTTTATGAAGAATCTCTGCTCATTGGAATGAAATGCAGTCATTTGAAATGAGAAAGGCCAGGATCC
TTTTTTGTACCTTACCCTGTCTTCAAGAGTAAAGGTGAACACTTACAGCTCTCCTCCTTGATGTCAATTTTGTATGTTGATCATTCCAAA
CTGAGAAGAATAAAGCCACATTTTAGACATATTTATAGAATCAATTAAAGCTATATGTCTAAAATTCGTAGGGCAACTTCTGAGAAGAAA
CACCGTCTTTTTCTTTTTTAATGGAAAGTGACAATGTGACATTAGTCATGTTGTGTGCGGTGACGCAGAGTAACTGAGGTAATCTGACTG
TTGCACTATGTGACATATTTCAGGACGTACTTGCTGCATTTGCAGCAGCCCTCTCTCTCTGTCCCTTCCCACAATTCTGCTGTTGCTGCA
ACTTGAGTTAATTGTGACAAATGCATCTTTGTGTTATATTTTGTTTGCTTCATAATTTCCAGAACTATATATAAATATATTTTTTAAATA
GCAAATATTGTAGTTAGTGAGTGATGATCACTCCAACCTTATCCTTACCATATTGGTTTCAGGGATAGGATTAAGAGTGTCTTTGGAAGA
GAAAAATACACACAACCCTGTGGTTTAGAATGACGCTGAGGCCTTAGGCTGTGGGCCTAGAACAACTATGTGAGTGAATTCACCCATCTC
ATACTTTGAATCAAGCATGCATTCCTGTTTCTCATTGTGAAGTATCCCCAGTTGTTTTCCTTCAGTGTTGAGTTTTTGTCCTTTTAAATT
TTATTATATTTTGCTCTCCCTAACATTTGACTGTTTTTTATAAAAGAAAAGAAAAAAAAAGAAATAAATAATACCCTCGATGCCACTGGA
TACTCACAAGCAGGGTTATGCTCCTTCATCTTGGGCTTGTTTGCCTAAATGAAAGGGTTTAATTTATTTTGTACCTCCTATGCGTGGGAT
AGTCCAGGGTGCAGAGCCAGGACTTGCTTGTAATTGCACCTGCTATACTTAAATGTATAGCCCTAGGCTCAATCACACTATGGAAAGAAA
CAAAAAAAGTATATTTAGAGCTTTAAAAGCTTTTTTATTTTTTTGTGGGGATGAGGGTGGGATGGGAAAGGGATGTATGGATGTTATTGG
CATTTTTAAGTGTTTAGAGTTTTTTGGGGTTTGGGGTGGTTTTTTTTCCTTGTTTTCCTTTTTTCCTTTTAATTGGATGCACTGACCTGG
CCCAGGAAATGAAGAGATTCTCTTTTGATGCTATTACCAATGTTATCATAAAGTGACAGTCACCTGTAACAAAAAGGTGGCACCAGACAT
GATCACTGATGTTTTATTTGCACATCAATATTTTTATTTTTGTATTCTGGCTCAGCTGCTTCTCTGAGTGGAGTTAAGGAATGAGCCACA
AAGATTTTTGTAGTAGGTATATTGGCATTGCATTTTATATTCCTCTATATTTAATTTTGAAAACCTAAAAGAAGGATTGTGCATCTTGAG
AGAAAGTTGAGCAAATTGTGATCTAGCGGAATGTTAATTTGTGCTGCTTCTTGTGCACGATAGCAGCAGTAGTATCTCTCTTGGAAATAA
ACATCCCATATTATGATGTCTATGAATATAGGTTTCCTTTTCTTCCTTCCCTCCCTCCTTCCCCCACCTTTCTCTTTTTTTTTTCTCTCT
CAGCTTCTCTTTTCCTCCTTCCCTCTTCCCTTCCTCTTTCTTTACTTTTTTTGAAATCACTTATTGTAAATAAGTTGTAATCCAAACCTC
ATGTATCAATGGGGAATTTTCAAATATAAATATTACCAATGCATTTTCTGGTTGTTGTCTGATTTTTGATTGAAGTATAATGAGAATGAC
ATGTCTGTTGCTTTTGGTTTGAGGACTTCGCTTTAGCTTCATAAATCTTTTGGTATTTTAGTATTTCATTGTTTTAGCAGGAGAGGGCAG
CAAAAGTTCATTTTCCCTGTTAGTAATGCTGTGGTTCATGATCGGTTTTAAATTTAGCTGTGTGTGTGTTTTTTTAAACAGCATCTCTTT
GTGAGTAGAGGTAAAAATGAAACATTTTTGATATGAAAAGTTGCATATGAAAATTATAGACTGGTTCAACCAGACAGTGAAGACTTCTGA
TCCACATCAAACTTAAAATGCCACAAAACAATCTTCCACCTCTGGCTAAAACATGCTACTTCCTTTTCAAACACCACAAAATACAAGCTG
AGTCTTAAACACTTGGAATTTAAAATGTTTTTCTTTGGAAATGATTTGCTTTCTTCAAAGTGGTAACAGAAACAAAAATGAAGGTGCTCC
CCAAAAAGAAATGTAACCTTCCCCTTTCACAGATGTGTGAGAGGTTCTGTACTGTGGGTGCATCATAATAAAGAAGCAGTGAAGAGTTTT

>94214_94214_1_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000344204_PPP2R5E_chr14_63848875_ENST00000337537_length(amino acids)=182AA_BP=115
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPRAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQREKKKEKEREELWKKLEDLELKRGLRRDGII

--------------------------------------------------------------
>94214_94214_2_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000344204_PPP2R5E_chr14_63848875_ENST00000422769_length(transcript)=729nt_BP=371nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGGGCTATTGTGGCGTTGGTGTACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCC
ACATACAAGTCAGATCGTCAGCGTGAGAAAAAGAAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGA
GGTCTTAGACGTGATGGAATAATTCCAACTTAACAAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAA
GATGGAGCAACAGTTTTCTGTATTGTGCAACTTTACAGTAGATTTCACCTTTGTTTCATTATTACAGCAGCACTGTATATACCTGTCTCT

>94214_94214_2_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000344204_PPP2R5E_chr14_63848875_ENST00000422769_length(amino acids)=182AA_BP=115
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPRAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQREKKKEKEREELWKKLEDLELKRGLRRDGII

--------------------------------------------------------------
>94214_94214_3_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000344204_PPP2R5E_chr14_63848875_ENST00000555899_length(transcript)=806nt_BP=371nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GGGTTTCGAAAAAACGATGAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAA
CGTGGAGGTCCCATTTTAACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCC
TGTATTCCCAGGGCTATTGTGGCGTTGGTGTACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCC
ACATACAATGAGAAAAAGAAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGAT
GGAATAATTCCAACTTAACAAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAAGATGGAGCAACAGTT
TTCTGTATTGTGCAACTTTACAGTAGATTTCACCTTTGTTTCATTATTACAGCAGCACTGTATATACCTGTCTCTAAGTAAAGGAAAAAA

>94214_94214_3_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000344204_PPP2R5E_chr14_63848875_ENST00000555899_length(amino acids)=177AA_BP=115
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF

--------------------------------------------------------------
>94214_94214_4_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000509967_PPP2R5E_chr14_63848875_ENST00000337537_length(transcript)=5206nt_BP=352nt
ATTTGGGATATCTAGAGGTTGTTTGTTGGTGTTCTGGGATCCTGAGGGACACTGCCAACTGTTAACCTTTGGCAGATAGTGACTGTTTTA
CTTCGATTTTATTTTCGTGGTAACCGTTTTTTAAAAAAGATTAATAAATTACCCAAGAGGACATGGCAGAAGGGTTTCGAAAAAACGATG
AAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTAA
CGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGGGCTATTG
TGGCGTTGGTGTACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAAGTCAGATCGTC
AGCGTGAGAAAAAGAAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGATGGAA
TAATTCCAACTTAACAAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAAGATGGAGCAACAGTTTTCT
GTATTGTGCAACTTTACAGTAGATTTCACCTTTGTTTCATTATTACAGCAGCACTGTATATACCTGTCTCTAAGTAAAGGAAAAAACAAA
ATAAGGACTTCAATCCAAAGTTTGGACAGTAGATGGACTTCTCAGAACTTTGCAAACATAATCATTGTTCTCACCCTCTTTTAAAAAAAA
AAATCGGTCTTCAAAGATCTGTTGATGAAATTGCTATGTTAAAATTCCATTATCGGGAGTTCCTTATTTATCACTAGCAGAGAGTATGAT
ACAATTTTCAAATGTGAACAATCTTAAATTTAGCTTGTCTTTCTGCTAAGCTGTTAAATGTATTTATAGTAAAGGAAGAAAAAAAGACTG
TCATTTCCTTATAAGTTTGTGTAACATCCTCCTCTGGATAACTTGACTGTAATTTAACATCTTTTTCTTTTGCACATCTTCCTGAGTTGA
ATGTCCACGTGGAATGGGGTCATGAATTATAAAAGTCCCTGATAAAAGTTTTGTTTACTGGGGTGAACATCTTTCCAGTAACCAGGTAGT
CCTGGTACTCCTTTAGTTTTAAAATTAGGAGTTAAGAGAGAAGAGGTGATAAACATAGTAGGGAAGGGAATATCGGATTCATGCATCAGT
TTATGGTGAATCCAAATCAATGTCTTGAATCCTTTGAAAACAGGCACTGGGACATCACAGGCTTCAGTACCTGACCAGTATTAGTTGCAT
ATATCATTGAACACACATACCAGAGATGTTTTAGAAATGTGAGAAAAACATCCTTTTGGACCATTTGAAATAAGAAAGACAAACACTAAA
CAATACAACCATGAAATTGATCACCGGGATTGCAAATCTAATTGGGAAAAGAGTTGAGCAAACAGCTTGGACTGTTTGGAGTTGTTGCCT
TACTTTTTAATATGTATTTATAAAGTATTCCAGCAAAAGAGGATGTAGCCTCTGGGAAAAAACAAACATGTTACAGTGTTTTTTGTAGAT
TCTCGTTCTATATCTCATCACAGCGCCAGCCCTGTTTTTAGCCGGAAAGGATTCAGGATAAACATTATTATGCATTCTGAATTGGATGCA
TATTCCTAACTACTGTATTTGTTACCAAAAGTGGTTCTACAAATGCTACTGAAAAAAATCTGGAAATTCCTAATGTCCTGAGTATTAATA
ATAAAGTTTAAAAATGCTTTTATATCAAAGGTGCATCGTGACCAAATTGTTTAAGAAAAAAAAACAAAAAAAACAAAATCTAGGGCTGTA
TTTTATATATATATATATATATATATATATATATATATCTTATTGGCTCTCTGCTTTGTATTTAAATGAAGAATCTTACATCTTGGGTAG
GTAAACTGCTGATAAAATTTGTGTACAGTATGTACTTACCTAATGCAGTTGCATTATTACGTACTGAAAGATATGTGTTTGGAGGTTTAT
TTCCAGGATGCATTTGCTTGTTTTGGTCATGGCAGCAGTGAGTTGGTAATCCTAAACCATCACTTCCAGCAGTATTCATGGTATAGAGCT
GATCTGTGTTCATATGTTGAATTGTGATAGTAGCAAACATGAACATATGAACTATTGTTGCTCTTAATAGAAATACAATATAAATATGGG
CTTGTATATTTTCTTCCTTACATTTAAATATAAAGTAGAATACGCAGTTTTATTATTTTCAAGAAAAAGAAAGAGAAGCTGCTGACCTTT
CTCCCCCATAAAGTTTTTCAGGATGATCAGGTCACAGTGTGTACGTAAGAGTCAGCTAATTATGGATATTGTCATCTCGGTAACTTTGTA
AAAAAACAAACAAAACTGGCATTGTTAATTCCAAAAAGAAAAAAAAAAGCAGTAAAAAAAAAAAGTCATATGCAACACCAGACGCAACAT
GGTTTAATGGAATTAATAGTTTTTTTTTTTTTTTTTTTAAAGAACATTGATGGGGATTCACTGTAAAGTTGGCAGAGGCTGCCAAAGACG
AAACAACTGACTTTAAAAATGCTGGAACAATGTGATAAAAAATAAATTTGTAACAAATCTTCTCCTTTTTAGCCCTTGTCATTTTAGCCC
TTTAGTTTCAACTCTGCATTATATTTAGTTTATATAGTGTAAACTTTTGTTTGCCATTAATTCATCTTTTTAGGTAGAAGACATTAAAAT
CACAGGTTTATGAAGAATCTCTGCTCATTGGAATGAAATGCAGTCATTTGAAATGAGAAAGGCCAGGATCCTTTTTTGTACCTTACCCTG
TCTTCAAGAGTAAAGGTGAACACTTACAGCTCTCCTCCTTGATGTCAATTTTGTATGTTGATCATTCCAAACTGAGAAGAATAAAGCCAC
ATTTTAGACATATTTATAGAATCAATTAAAGCTATATGTCTAAAATTCGTAGGGCAACTTCTGAGAAGAAACACCGTCTTTTTCTTTTTT
AATGGAAAGTGACAATGTGACATTAGTCATGTTGTGTGCGGTGACGCAGAGTAACTGAGGTAATCTGACTGTTGCACTATGTGACATATT
TCAGGACGTACTTGCTGCATTTGCAGCAGCCCTCTCTCTCTGTCCCTTCCCACAATTCTGCTGTTGCTGCAACTTGAGTTAATTGTGACA
AATGCATCTTTGTGTTATATTTTGTTTGCTTCATAATTTCCAGAACTATATATAAATATATTTTTTAAATAGCAAATATTGTAGTTAGTG
AGTGATGATCACTCCAACCTTATCCTTACCATATTGGTTTCAGGGATAGGATTAAGAGTGTCTTTGGAAGAGAAAAATACACACAACCCT
GTGGTTTAGAATGACGCTGAGGCCTTAGGCTGTGGGCCTAGAACAACTATGTGAGTGAATTCACCCATCTCATACTTTGAATCAAGCATG
CATTCCTGTTTCTCATTGTGAAGTATCCCCAGTTGTTTTCCTTCAGTGTTGAGTTTTTGTCCTTTTAAATTTTATTATATTTTGCTCTCC
CTAACATTTGACTGTTTTTTATAAAAGAAAAGAAAAAAAAAGAAATAAATAATACCCTCGATGCCACTGGATACTCACAAGCAGGGTTAT
GCTCCTTCATCTTGGGCTTGTTTGCCTAAATGAAAGGGTTTAATTTATTTTGTACCTCCTATGCGTGGGATAGTCCAGGGTGCAGAGCCA
GGACTTGCTTGTAATTGCACCTGCTATACTTAAATGTATAGCCCTAGGCTCAATCACACTATGGAAAGAAACAAAAAAAGTATATTTAGA
GCTTTAAAAGCTTTTTTATTTTTTTGTGGGGATGAGGGTGGGATGGGAAAGGGATGTATGGATGTTATTGGCATTTTTAAGTGTTTAGAG
TTTTTTGGGGTTTGGGGTGGTTTTTTTTCCTTGTTTTCCTTTTTTCCTTTTAATTGGATGCACTGACCTGGCCCAGGAAATGAAGAGATT
CTCTTTTGATGCTATTACCAATGTTATCATAAAGTGACAGTCACCTGTAACAAAAAGGTGGCACCAGACATGATCACTGATGTTTTATTT
GCACATCAATATTTTTATTTTTGTATTCTGGCTCAGCTGCTTCTCTGAGTGGAGTTAAGGAATGAGCCACAAAGATTTTTGTAGTAGGTA
TATTGGCATTGCATTTTATATTCCTCTATATTTAATTTTGAAAACCTAAAAGAAGGATTGTGCATCTTGAGAGAAAGTTGAGCAAATTGT
GATCTAGCGGAATGTTAATTTGTGCTGCTTCTTGTGCACGATAGCAGCAGTAGTATCTCTCTTGGAAATAAACATCCCATATTATGATGT
CTATGAATATAGGTTTCCTTTTCTTCCTTCCCTCCCTCCTTCCCCCACCTTTCTCTTTTTTTTTTCTCTCTCAGCTTCTCTTTTCCTCCT
TCCCTCTTCCCTTCCTCTTTCTTTACTTTTTTTGAAATCACTTATTGTAAATAAGTTGTAATCCAAACCTCATGTATCAATGGGGAATTT
TCAAATATAAATATTACCAATGCATTTTCTGGTTGTTGTCTGATTTTTGATTGAAGTATAATGAGAATGACATGTCTGTTGCTTTTGGTT
TGAGGACTTCGCTTTAGCTTCATAAATCTTTTGGTATTTTAGTATTTCATTGTTTTAGCAGGAGAGGGCAGCAAAAGTTCATTTTCCCTG
TTAGTAATGCTGTGGTTCATGATCGGTTTTAAATTTAGCTGTGTGTGTGTTTTTTTAAACAGCATCTCTTTGTGAGTAGAGGTAAAAATG
AAACATTTTTGATATGAAAAGTTGCATATGAAAATTATAGACTGGTTCAACCAGACAGTGAAGACTTCTGATCCACATCAAACTTAAAAT
GCCACAAAACAATCTTCCACCTCTGGCTAAAACATGCTACTTCCTTTTCAAACACCACAAAATACAAGCTGAGTCTTAAACACTTGGAAT
TTAAAATGTTTTTCTTTGGAAATGATTTGCTTTCTTCAAAGTGGTAACAGAAACAAAAATGAAGGTGCTCCCCAAAAAGAAATGTAACCT

>94214_94214_4_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000509967_PPP2R5E_chr14_63848875_ENST00000337537_length(amino acids)=133AA_BP=66
MAEGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPRAIVALVYNVLKAFMEMNSTMFDE

--------------------------------------------------------------
>94214_94214_5_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000509967_PPP2R5E_chr14_63848875_ENST00000422769_length(transcript)=710nt_BP=352nt
ATTTGGGATATCTAGAGGTTGTTTGTTGGTGTTCTGGGATCCTGAGGGACACTGCCAACTGTTAACCTTTGGCAGATAGTGACTGTTTTA
CTTCGATTTTATTTTCGTGGTAACCGTTTTTTAAAAAAGATTAATAAATTACCCAAGAGGACATGGCAGAAGGGTTTCGAAAAAACGATG
AAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTAA
CGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGGGCTATTG
TGGCGTTGGTGTACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAAGTCAGATCGTC
AGCGTGAGAAAAAGAAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGATGGAA
TAATTCCAACTTAACAAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAAGATGGAGCAACAGTTTTCT

>94214_94214_5_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000509967_PPP2R5E_chr14_63848875_ENST00000422769_length(amino acids)=133AA_BP=66
MAEGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPRAIVALVYNVLKAFMEMNSTMFDE

--------------------------------------------------------------
>94214_94214_6_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000509967_PPP2R5E_chr14_63848875_ENST00000555899_length(transcript)=787nt_BP=352nt
ATTTGGGATATCTAGAGGTTGTTTGTTGGTGTTCTGGGATCCTGAGGGACACTGCCAACTGTTAACCTTTGGCAGATAGTGACTGTTTTA
CTTCGATTTTATTTTCGTGGTAACCGTTTTTTAAAAAAGATTAATAAATTACCCAAGAGGACATGGCAGAAGGGTTTCGAAAAAACGATG
AAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTAA
CGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGGGCTATTG
TGGCGTTGGTGTACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAATGAGAAAAAGA
AAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGATGGAATAATTCCAACTTAAC
AAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAAGATGGAGCAACAGTTTTCTGTATTGTGCAACTTT
ACAGTAGATTTCACCTTTGTTTCATTATTACAGCAGCACTGTATATACCTGTCTCTAAGTAAAGGAAAAAACAAAATAAGGACTTCAATC

>94214_94214_6_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000509967_PPP2R5E_chr14_63848875_ENST00000555899_length(amino acids)=128AA_BP=66
MAEGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPRAIVALVYNVLKAFMEMNSTMFDE

--------------------------------------------------------------
>94214_94214_7_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000537187_PPP2R5E_chr14_63848875_ENST00000337537_length(transcript)=5207nt_BP=353nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGGGCTATT
GTGGCGTTGGTGTACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAAGTCAGATCGT
CAGCGTGAGAAAAAGAAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGATGGA
ATAATTCCAACTTAACAAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAAGATGGAGCAACAGTTTTC
TGTATTGTGCAACTTTACAGTAGATTTCACCTTTGTTTCATTATTACAGCAGCACTGTATATACCTGTCTCTAAGTAAAGGAAAAAACAA
AATAAGGACTTCAATCCAAAGTTTGGACAGTAGATGGACTTCTCAGAACTTTGCAAACATAATCATTGTTCTCACCCTCTTTTAAAAAAA
AAAATCGGTCTTCAAAGATCTGTTGATGAAATTGCTATGTTAAAATTCCATTATCGGGAGTTCCTTATTTATCACTAGCAGAGAGTATGA
TACAATTTTCAAATGTGAACAATCTTAAATTTAGCTTGTCTTTCTGCTAAGCTGTTAAATGTATTTATAGTAAAGGAAGAAAAAAAGACT
GTCATTTCCTTATAAGTTTGTGTAACATCCTCCTCTGGATAACTTGACTGTAATTTAACATCTTTTTCTTTTGCACATCTTCCTGAGTTG
AATGTCCACGTGGAATGGGGTCATGAATTATAAAAGTCCCTGATAAAAGTTTTGTTTACTGGGGTGAACATCTTTCCAGTAACCAGGTAG
TCCTGGTACTCCTTTAGTTTTAAAATTAGGAGTTAAGAGAGAAGAGGTGATAAACATAGTAGGGAAGGGAATATCGGATTCATGCATCAG
TTTATGGTGAATCCAAATCAATGTCTTGAATCCTTTGAAAACAGGCACTGGGACATCACAGGCTTCAGTACCTGACCAGTATTAGTTGCA
TATATCATTGAACACACATACCAGAGATGTTTTAGAAATGTGAGAAAAACATCCTTTTGGACCATTTGAAATAAGAAAGACAAACACTAA
ACAATACAACCATGAAATTGATCACCGGGATTGCAAATCTAATTGGGAAAAGAGTTGAGCAAACAGCTTGGACTGTTTGGAGTTGTTGCC
TTACTTTTTAATATGTATTTATAAAGTATTCCAGCAAAAGAGGATGTAGCCTCTGGGAAAAAACAAACATGTTACAGTGTTTTTTGTAGA
TTCTCGTTCTATATCTCATCACAGCGCCAGCCCTGTTTTTAGCCGGAAAGGATTCAGGATAAACATTATTATGCATTCTGAATTGGATGC
ATATTCCTAACTACTGTATTTGTTACCAAAAGTGGTTCTACAAATGCTACTGAAAAAAATCTGGAAATTCCTAATGTCCTGAGTATTAAT
AATAAAGTTTAAAAATGCTTTTATATCAAAGGTGCATCGTGACCAAATTGTTTAAGAAAAAAAAACAAAAAAAACAAAATCTAGGGCTGT
ATTTTATATATATATATATATATATATATATATATATATCTTATTGGCTCTCTGCTTTGTATTTAAATGAAGAATCTTACATCTTGGGTA
GGTAAACTGCTGATAAAATTTGTGTACAGTATGTACTTACCTAATGCAGTTGCATTATTACGTACTGAAAGATATGTGTTTGGAGGTTTA
TTTCCAGGATGCATTTGCTTGTTTTGGTCATGGCAGCAGTGAGTTGGTAATCCTAAACCATCACTTCCAGCAGTATTCATGGTATAGAGC
TGATCTGTGTTCATATGTTGAATTGTGATAGTAGCAAACATGAACATATGAACTATTGTTGCTCTTAATAGAAATACAATATAAATATGG
GCTTGTATATTTTCTTCCTTACATTTAAATATAAAGTAGAATACGCAGTTTTATTATTTTCAAGAAAAAGAAAGAGAAGCTGCTGACCTT
TCTCCCCCATAAAGTTTTTCAGGATGATCAGGTCACAGTGTGTACGTAAGAGTCAGCTAATTATGGATATTGTCATCTCGGTAACTTTGT
AAAAAAACAAACAAAACTGGCATTGTTAATTCCAAAAAGAAAAAAAAAAGCAGTAAAAAAAAAAAGTCATATGCAACACCAGACGCAACA
TGGTTTAATGGAATTAATAGTTTTTTTTTTTTTTTTTTTAAAGAACATTGATGGGGATTCACTGTAAAGTTGGCAGAGGCTGCCAAAGAC
GAAACAACTGACTTTAAAAATGCTGGAACAATGTGATAAAAAATAAATTTGTAACAAATCTTCTCCTTTTTAGCCCTTGTCATTTTAGCC
CTTTAGTTTCAACTCTGCATTATATTTAGTTTATATAGTGTAAACTTTTGTTTGCCATTAATTCATCTTTTTAGGTAGAAGACATTAAAA
TCACAGGTTTATGAAGAATCTCTGCTCATTGGAATGAAATGCAGTCATTTGAAATGAGAAAGGCCAGGATCCTTTTTTGTACCTTACCCT
GTCTTCAAGAGTAAAGGTGAACACTTACAGCTCTCCTCCTTGATGTCAATTTTGTATGTTGATCATTCCAAACTGAGAAGAATAAAGCCA
CATTTTAGACATATTTATAGAATCAATTAAAGCTATATGTCTAAAATTCGTAGGGCAACTTCTGAGAAGAAACACCGTCTTTTTCTTTTT
TAATGGAAAGTGACAATGTGACATTAGTCATGTTGTGTGCGGTGACGCAGAGTAACTGAGGTAATCTGACTGTTGCACTATGTGACATAT
TTCAGGACGTACTTGCTGCATTTGCAGCAGCCCTCTCTCTCTGTCCCTTCCCACAATTCTGCTGTTGCTGCAACTTGAGTTAATTGTGAC
AAATGCATCTTTGTGTTATATTTTGTTTGCTTCATAATTTCCAGAACTATATATAAATATATTTTTTAAATAGCAAATATTGTAGTTAGT
GAGTGATGATCACTCCAACCTTATCCTTACCATATTGGTTTCAGGGATAGGATTAAGAGTGTCTTTGGAAGAGAAAAATACACACAACCC
TGTGGTTTAGAATGACGCTGAGGCCTTAGGCTGTGGGCCTAGAACAACTATGTGAGTGAATTCACCCATCTCATACTTTGAATCAAGCAT
GCATTCCTGTTTCTCATTGTGAAGTATCCCCAGTTGTTTTCCTTCAGTGTTGAGTTTTTGTCCTTTTAAATTTTATTATATTTTGCTCTC
CCTAACATTTGACTGTTTTTTATAAAAGAAAAGAAAAAAAAAGAAATAAATAATACCCTCGATGCCACTGGATACTCACAAGCAGGGTTA
TGCTCCTTCATCTTGGGCTTGTTTGCCTAAATGAAAGGGTTTAATTTATTTTGTACCTCCTATGCGTGGGATAGTCCAGGGTGCAGAGCC
AGGACTTGCTTGTAATTGCACCTGCTATACTTAAATGTATAGCCCTAGGCTCAATCACACTATGGAAAGAAACAAAAAAAGTATATTTAG
AGCTTTAAAAGCTTTTTTATTTTTTTGTGGGGATGAGGGTGGGATGGGAAAGGGATGTATGGATGTTATTGGCATTTTTAAGTGTTTAGA
GTTTTTTGGGGTTTGGGGTGGTTTTTTTTCCTTGTTTTCCTTTTTTCCTTTTAATTGGATGCACTGACCTGGCCCAGGAAATGAAGAGAT
TCTCTTTTGATGCTATTACCAATGTTATCATAAAGTGACAGTCACCTGTAACAAAAAGGTGGCACCAGACATGATCACTGATGTTTTATT
TGCACATCAATATTTTTATTTTTGTATTCTGGCTCAGCTGCTTCTCTGAGTGGAGTTAAGGAATGAGCCACAAAGATTTTTGTAGTAGGT
ATATTGGCATTGCATTTTATATTCCTCTATATTTAATTTTGAAAACCTAAAAGAAGGATTGTGCATCTTGAGAGAAAGTTGAGCAAATTG
TGATCTAGCGGAATGTTAATTTGTGCTGCTTCTTGTGCACGATAGCAGCAGTAGTATCTCTCTTGGAAATAAACATCCCATATTATGATG
TCTATGAATATAGGTTTCCTTTTCTTCCTTCCCTCCCTCCTTCCCCCACCTTTCTCTTTTTTTTTTCTCTCTCAGCTTCTCTTTTCCTCC
TTCCCTCTTCCCTTCCTCTTTCTTTACTTTTTTTGAAATCACTTATTGTAAATAAGTTGTAATCCAAACCTCATGTATCAATGGGGAATT
TTCAAATATAAATATTACCAATGCATTTTCTGGTTGTTGTCTGATTTTTGATTGAAGTATAATGAGAATGACATGTCTGTTGCTTTTGGT
TTGAGGACTTCGCTTTAGCTTCATAAATCTTTTGGTATTTTAGTATTTCATTGTTTTAGCAGGAGAGGGCAGCAAAAGTTCATTTTCCCT
GTTAGTAATGCTGTGGTTCATGATCGGTTTTAAATTTAGCTGTGTGTGTGTTTTTTTAAACAGCATCTCTTTGTGAGTAGAGGTAAAAAT
GAAACATTTTTGATATGAAAAGTTGCATATGAAAATTATAGACTGGTTCAACCAGACAGTGAAGACTTCTGATCCACATCAAACTTAAAA
TGCCACAAAACAATCTTCCACCTCTGGCTAAAACATGCTACTTCCTTTTCAAACACCACAAAATACAAGCTGAGTCTTAAACACTTGGAA
TTTAAAATGTTTTTCTTTGGAAATGATTTGCTTTCTTCAAAGTGGTAACAGAAACAAAAATGAAGGTGCTCCCCAAAAAGAAATGTAACC

>94214_94214_7_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000537187_PPP2R5E_chr14_63848875_ENST00000337537_length(amino acids)=182AA_BP=115
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPRAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQREKKKEKEREELWKKLEDLELKRGLRRDGII

--------------------------------------------------------------
>94214_94214_8_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000537187_PPP2R5E_chr14_63848875_ENST00000422769_length(transcript)=711nt_BP=353nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGGGCTATT
GTGGCGTTGGTGTACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAAGTCAGATCGT
CAGCGTGAGAAAAAGAAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGATGGA
ATAATTCCAACTTAACAAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAAGATGGAGCAACAGTTTTC

>94214_94214_8_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000537187_PPP2R5E_chr14_63848875_ENST00000422769_length(amino acids)=182AA_BP=115
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPRAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQREKKKEKEREELWKKLEDLELKRGLRRDGII

--------------------------------------------------------------
>94214_94214_9_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000537187_PPP2R5E_chr14_63848875_ENST00000555899_length(transcript)=788nt_BP=353nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGGGTTTCGAAAAAACGAT
GAAATGAAAGCTATGGATGTTTTACCAATTTTGAAGGAAAAAGTTGCATACCTTTCAGGTGGGAGAGATAAACGTGGAGGTCCCATTTTA
ACGTTTCCGGCCCGCAGCAATCATGACAGAATACGACAGGAGGATCTCAGGAGACTCATTTCCTATCTAGCCTGTATTCCCAGGGCTATT
GTGGCGTTGGTGTACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAATGAGAAAAAG
AAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGATGGAATAATTCCAACTTAA
CAAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAAGATGGAGCAACAGTTTTCTGTATTGTGCAACTT
TACAGTAGATTTCACCTTTGTTTCATTATTACAGCAGCACTGTATATACCTGTCTCTAAGTAAAGGAAAAAACAAAATAAGGACTTCAAT

>94214_94214_9_TRIO-PPP2R5E_TRIO_chr5_14280545_ENST00000537187_PPP2R5E_chr14_63848875_ENST00000555899_length(amino acids)=177AA_BP=115
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF

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Fusion Gene PPI Analysis for TRIO-PPP2R5E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIO-PPP2R5E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIO-PPP2R5E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource