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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIP10-C1orf186 (FusionGDB2 ID:94227)

Fusion Gene Summary for TRIP10-C1orf186

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIP10-C1orf186
Fusion gene ID: 94227
HgeneTgene
Gene symbol

TRIP10

C1orf186

Gene ID

9322

440712

Gene namethyroid hormone receptor interactor 10regulator of hemoglobinization and erythroid cell expansion
SynonymsCIP4|HSTP|STOT|STP|TRIP-10C1orf186
Cytomap

19p13.3

1q32.1

Type of geneprotein-codingprotein-coding
Descriptioncdc42-interacting protein 4TR-interacting protein 10protein Felicsalt tolerant proteinsalt toleratorthyroid receptor-interacting protein 10regulator of hemoglobinization and erythroid cell expansion proteinregulator of human erythroid cell expansionregulator of human erythroid cell expansion proteinuncharacterized protein C1orf186
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000313244, ENST00000313285, 
ENST00000596758, ENST00000600428, 
ENST00000596543, 		ENST00000469540, 
ENST00000331555, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 4=64
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIP10 [Title/Abstract] AND C1orf186 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIP10(6750644)-C1orf186(206241676), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRIP10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C1orf186 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A3DGTRIP10chr19

6750644

+C1orf186chr1

206241676

-


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Fusion Gene ORF analysis for TRIP10-C1orf186

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000313244ENST00000469540TRIP10chr19

6750644

+C1orf186chr1

206241676

-
5CDS-intronENST00000313285ENST00000469540TRIP10chr19

6750644

+C1orf186chr1

206241676

-
5CDS-intronENST00000596758ENST00000469540TRIP10chr19

6750644

+C1orf186chr1

206241676

-
5CDS-intronENST00000600428ENST00000469540TRIP10chr19

6750644

+C1orf186chr1

206241676

-
In-frameENST00000313244ENST00000331555TRIP10chr19

6750644

+C1orf186chr1

206241676

-
In-frameENST00000313285ENST00000331555TRIP10chr19

6750644

+C1orf186chr1

206241676

-
In-frameENST00000596758ENST00000331555TRIP10chr19

6750644

+C1orf186chr1

206241676

-
In-frameENST00000600428ENST00000331555TRIP10chr19

6750644

+C1orf186chr1

206241676

-
intron-3CDSENST00000596543ENST00000331555TRIP10chr19

6750644

+C1orf186chr1

206241676

-
intron-intronENST00000596543ENST00000469540TRIP10chr19

6750644

+C1orf186chr1

206241676

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000600428TRIP10chr196750644+ENST00000331555C1orf186chr1206241676-272518113852217610
ENST00000313285TRIP10chr196750644+ENST00000331555C1orf186chr1206241676-24851571821977631
ENST00000313244TRIP10chr196750644+ENST00000331555C1orf186chr1206241676-26061692352098687
ENST00000596758TRIP10chr196750644+ENST00000331555C1orf186chr1206241676-2403148901895631

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000600428ENST00000331555TRIP10chr196750644+C1orf186chr1206241676-0.0034968060.99650323
ENST00000313285ENST00000331555TRIP10chr196750644+C1orf186chr1206241676-0.0058267530.9941732
ENST00000313244ENST00000331555TRIP10chr196750644+C1orf186chr1206241676-0.0090776990.9909223
ENST00000596758ENST00000331555TRIP10chr196750644+C1orf186chr1206241676-0.0055311530.9944688

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Fusion Genomic Features for TRIP10-C1orf186


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIP10-C1orf186


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:6750644/chr1:206241676)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+1415388_481552602.0Coiled coil.
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+141567_259552602.0Coiled coil.
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+1314388_481496546.0Coiled coil.
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+131467_259496546.0Coiled coil.
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+14151_264552602.0DomainF-BAR
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+1415393_470552602.0DomainREM-1
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+13141_264496546.0DomainF-BAR
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+1314393_470496546.0DomainREM-1
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+14151_117552602.0RegionRequired for translocation to the plasma membrane in response to insulin
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+13141_117496546.0RegionRequired for translocation to the plasma membrane in response to insulin

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+1415540_601552602.0DomainSH3
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+1314540_601496546.0DomainSH3
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+1415538_601552602.0RegionNote=Required for podosome formation
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+1314538_601496546.0RegionNote=Required for podosome formation
TgeneC1orf186chr19:6750644chr1:206241676ENST00000331555269_2937173.0TransmembraneHelical


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Fusion Gene Sequence for TRIP10-C1orf186


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94227_94227_1_TRIP10-C1orf186_TRIP10_chr19_6750644_ENST00000313244_C1orf186_chr1_206241676_ENST00000331555_length(transcript)=2606nt_BP=1692nt
GCGGTGGTGGCTGCGGCGGCGGCGGCGGGAGCAGCATGGATTGGGGCACTGAGCTGTGGGATCAGTTCGAGGTGCTCGAGCGCCACACGC
AGTGGGGGCTGGACCTGTTGGACAGATATGTAAAGTTCGTGAAAGAACGCACCGAAGTGGAACAGGCTTACGCCAAACAACTGCGGAGCC
TGGTGAAAAAATATCTGCCCAAGAGACCTGCCAAGGATGATCCTGAGTCCAAATTCAGCCAGCAACAGTCCTTCGTACAGATTCTCCAGG
AGGTGAATGACTTTGCAGGCCAGCGGGAGCTGGTGGCTGAGAACCTCAGTGTCCGTGTATGTCTTGAGCTGACCAAGTACTCACAAGAGA
TGAAACAGGAGAGGAAGATGCACTTCCAAGAAGGGCGGCGGGCCCAGCAGCAGCTGGAAAATGGCTTTAAACAGCTGGAGAATAGTAAGC
GTAAATTTGAGCGGGACTGCCGGGAGGCAGAGAAGGCAGCCCAGACTGCTGAACGGCTAGACCAGGATATCAACGCCACCAAGGCTGATG
TGGAGAAGGCCAAGCAGCAAGCCCACCTTCGGAGTCACATGGCCGAAGAAAGCAAAAACGAATATGCGGCTCAACTGCAGCGCTTCAACC
GAGACCAAGCCCACTTCTATTTTTCACAGATGCCCCAGATATTCGATAAGCTCCAAGACATGGATGAACGCAGGGCCACCCGCCTGGGTG
CCGGGTATGGGCTCCTGTCGGAGGCCGAGCTGGAGGTGGTGCCCATAATAGCCAAGTGCTTGGAGGGCATGAAGGTGGCTGCAAATGCTG
TGGATCCCAAGAACGACTCCCACGTCCTTATAGAGCTGCACAAGTCAGGTTTTGCCCGCCCGGGCGACGTGGAATTCGAGGACTTCAGCC
AGCCCATGAACCGTGCACCCTCCGACAGCAGTCTGGGCACCCCCTCGGATGGACGGCCTGAACTCCGAGGCCCGGGTCGCAGCCGCACCA
AGCGCTGGCCTTTTGGCAAGAAGAACAAGCCTCGCCCCCCACCCCTCTCCCCCCTGGGGGGCCCCGTACCCTCGGCATTGCCTAACGGAC
CCCCGTCCCCCCGCTCCGGCCGTGACCCCTTGGCCATACTGAGCGAGATCAGTAAGTCGGTCAAACCGAGGCTAGCATCCTTCCGCAGCC
TTCGAGGCAGCCGTGGGACAGTGGTGACCGAGGATTTTAGCCACTTGCCCCCAGAGCAGCAGCGAAAACGGCTTCAACAGCAGTTGGAAG
AACGCAGTCGTGAACTTCAGAAGGAGGTTGACCAGAGGGAAGCCCTAAAGAAAATGAAGGATGTCTATGAGAAGACACCTCAGATGGGGG
ACCCCGCCAGCTTGGAGCCCCAGATCGCTGAAACCCTGAGCAACATTGAACGGCTGAAATTGGAAGTGCAGAAGTATGAGGCGTGGCTGG
CAGAAGCTGAAAGTCGAGTCCTTAGCAACCGGGGAGACAGCCTGAGCCGGCACGCCCGGCCTCCCGACCCCCCCGCTAGCGCCCCGCCAG
ACAGCAGCAGCAACAGCGCATCACAGGACACCAAGGAGAGCTCTGAAGAGCCTCCCTCAGAAGAGAGCCAGGACACCCCCATTTACACGG
AGTTTGATGAGGATTTCGAGGAGGAACCCACATCCCCCATAGGTCACTGTGTGGCCATCTACCACTTTGAAGCCCACAAGAGTGAACAGA
TACTGAAAGCGGCCAGTCTCCAGGTTCCCAGGCCCAGCCCTGGCCACCATCATCCACCTGCTGTCAAAGAGATGAAGGAGACTCAGACAG
AGAGAGACATCCCAATGTCTGATTCCCTTTACAGGCATGACAGCGACACACCCTCAGATAGCTTGGATAGCTCCTGCAGTTCGCCTCCTG
CCTGCCAGGCCACAGAGGATGTGGATTACACACAAGTCGTCTTTTCTGACCCTGGAGAACTAAAAAATGACTCCCCGCTGGACTATGAGA
ACATAAAGGAAATCACAGATTATGTCAATGTCAATCCAGAAAGACACAAGCCCAGTTTCTGGTATTTTGTCAACCCTGCTCTGTCTGAGC
CAGCGGAATATGATCAAGTGGCCATGTGAATTCCAAATATTTTTAATGGGGTCCAGTTCTCTATGGATTCTTACATTTAATTTGTAGGGA
AATGCCATTTTTCCCCCTTAAACAAGGCATGGGGCTCACAAGTCTATGGAGACAGGCCAAAAAGAATGTGGAGAAGAAAACTGATAAATA
CACAGAGGTCCTCAAGACCCATGGACTCCTGGTCTGTACCCAAAAAAGCTGTTCGTTCCTCAAAAACAAAAACAAGGCTTGGCTGGGAAA
ACAGGCCAATGCCCCGGCAAGAAAGGTTGAGATCAGATGTTAGGAAGAACTTTCAGGTAAAGTATGAGAACTATGGAGTCCATCAGCAGA
GATAGTAGTGAAGTCTCTCCCCAGGGAAAATTTTAAAAAGGTTGAATCAGCTGTTGTAGAGTTCTATTTGGCAATCTCATGGTTAAATGA

>94227_94227_1_TRIP10-C1orf186_TRIP10_chr19_6750644_ENST00000313244_C1orf186_chr1_206241676_ENST00000331555_length(amino acids)=687AA_BP=552
MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQQSFVQILQEVNDFAGQRELV
AENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRS
HMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIE
LHKSGFARPGDVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKPRPPPLSPLGGPVPSALPNGPPSPRSGRDPLA
ILSEISKSVKPRLASFRSLRGSRGTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAET
LSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTS
PIGHCVAIYHFEAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKETQTERDIPMSDSLYRHDSDTPSDSLDSSCSSPPACQATEDVDYTQ

--------------------------------------------------------------
>94227_94227_2_TRIP10-C1orf186_TRIP10_chr19_6750644_ENST00000313285_C1orf186_chr1_206241676_ENST00000331555_length(transcript)=2485nt_BP=1571nt
GAGTCTCCCCGGGGAGGGCGGCGGGCGGCGGGCGGCGGGGACCGGGTGCGGTGGTGGCTGCGGCGGCGGCGGCGGGAGCAGCATGGATTG
GGGCACTGAGCTGTGGGATCAGTTCGAGGTGCTCGAGCGCCACACGCAGTGGGGGCTGGACCTGTTGGACAGATATGTAAAGTTCGTGAA
AGAACGCACCGAAGTGGAACAGGCTTACGCCAAACAACTGCGGAGCCTGGTGAAAAAATATCTGCCCAAGAGACCTGCCAAGGATGATCC
TGAGTCCAAATTCAGCCAGCAACAGTCCTTCGTACAGATTCTCCAGGAGGTGAATGACTTTGCAGGCCAGCGGGAGCTGGTGGCTGAGAA
CCTCAGTGTCCGTGTATGTCTTGAGCTGACCAAGTACTCACAAGAGATGAAACAGGAGAGGAAGATGCACTTCCAAGAAGGGCGGCGGGC
CCAGCAGCAGCTGGAAAATGGCTTTAAACAGCTGGAGAATAGTAAGCGTAAATTTGAGCGGGACTGCCGGGAGGCAGAGAAGGCAGCCCA
GACTGCTGAACGGCTAGACCAGGATATCAACGCCACCAAGGCTGATGTGGAGAAGGCCAAGCAGCAAGCCCACCTTCGGAGTCACATGGC
CGAAGAAAGCAAAAACGAATATGCGGCTCAACTGCAGCGCTTCAACCGAGACCAAGCCCACTTCTATTTTTCACAGATGCCCCAGATATT
CGATAAGCTCCAAGACATGGATGAACGCAGGGCCACCCGCCTGGGTGCCGGGTATGGGCTCCTGTCGGAGGCCGAGCTGGAGGTGGTGCC
CATAATAGCCAAGTGCTTGGAGGGCATGAAGGTGGCTGCAAATGCTGTGGATCCCAAGAACGACTCCCACGTCCTTATAGAGCTGCACAA
GTCAGGTTTTGCCCGCCCGGGCGACGTGGAATTCGAGGACTTCAGCCAGCCCATGAACCGTGCACCCTCCGACAGCAGTCTGGGCACCCC
CTCGGATGGACGGCCTGAACTCCGAGGCCCGGGTCGCAGCCGCACCAAGCGCTGGCCTTTTGGCAAGAAGAACAAGACAGTGGTGACCGA
GGATTTTAGCCACTTGCCCCCAGAGCAGCAGCGAAAACGGCTTCAACAGCAGTTGGAAGAACGCAGTCGTGAACTTCAGAAGGAGGTTGA
CCAGAGGGAAGCCCTAAAGAAAATGAAGGATGTCTATGAGAAGACACCTCAGATGGGGGACCCCGCCAGCTTGGAGCCCCAGATCGCTGA
AACCCTGAGCAACATTGAACGGCTGAAATTGGAAGTGCAGAAGTATGAGGCGTGGCTGGCAGAAGCTGAAAGTCGAGTCCTTAGCAACCG
GGGAGACAGCCTGAGCCGGCACGCCCGGCCTCCCGACCCCCCCGCTAGCGCCCCGCCAGACAGCAGCAGCAACAGCGCATCACAGGACAC
CAAGGAGAGCTCTGAAGAGCCTCCCTCAGAAGAGAGCCAGGACACCCCCATTTACACGGAGTTTGATGAGGATTTCGAGGAGGAACCCAC
ATCCCCCATAGGTCACTGTGTGGCCATCTACCACTTTGAAGCCCACAAGAGTGAACAGATACTGAAAGCGGCCAGTCTCCAGGTTCCCAG
GCCCAGCCCTGGCCACCATCATCCACCTGCTGTCAAAGAGATGAAGGAGACTCAGACAGAGAGAGACATCCCAATGTCTGATTCCCTTTA
CAGGCATGACAGCGACACACCCTCAGATAGCTTGGATAGCTCCTGCAGTTCGCCTCCTGCCTGCCAGGCCACAGAGGATGTGGATTACAC
ACAAGTCGTCTTTTCTGACCCTGGAGAACTAAAAAATGACTCCCCGCTGGACTATGAGAACATAAAGGAAATCACAGATTATGTCAATGT
CAATCCAGAAAGACACAAGCCCAGTTTCTGGTATTTTGTCAACCCTGCTCTGTCTGAGCCAGCGGAATATGATCAAGTGGCCATGTGAAT
TCCAAATATTTTTAATGGGGTCCAGTTCTCTATGGATTCTTACATTTAATTTGTAGGGAAATGCCATTTTTCCCCCTTAAACAAGGCATG
GGGCTCACAAGTCTATGGAGACAGGCCAAAAAGAATGTGGAGAAGAAAACTGATAAATACACAGAGGTCCTCAAGACCCATGGACTCCTG
GTCTGTACCCAAAAAAGCTGTTCGTTCCTCAAAAACAAAAACAAGGCTTGGCTGGGAAAACAGGCCAATGCCCCGGCAAGAAAGGTTGAG
ATCAGATGTTAGGAAGAACTTTCAGGTAAAGTATGAGAACTATGGAGTCCATCAGCAGAGATAGTAGTGAAGTCTCTCCCCAGGGAAAAT
TTTAAAAAGGTTGAATCAGCTGTTGTAGAGTTCTATTTGGCAATCTCATGGTTAAATGACTTCCCTTTGAGCTCTTTAATTATTGGCAAT

>94227_94227_2_TRIP10-C1orf186_TRIP10_chr19_6750644_ENST00000313285_C1orf186_chr1_206241676_ENST00000331555_length(amino acids)=631AA_BP=496
MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQQSFVQILQEVNDFAGQRELV
AENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRS
HMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIE
LHKSGFARPGDVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKTVVTEDFSHLPPEQQRKRLQQQLEERSRELQK
EVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSAS
QDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKETQTERDIPMSD
SLYRHDSDTPSDSLDSSCSSPPACQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVNPALSEPAEYDQVA

--------------------------------------------------------------
>94227_94227_3_TRIP10-C1orf186_TRIP10_chr19_6750644_ENST00000596758_C1orf186_chr1_206241676_ENST00000331555_length(transcript)=2403nt_BP=1489nt
ATGGATTGGGGCACTGAGCTGTGGGATCAGTTCGAGGTGCTCGAGCGCCACACGCAGTGGGGGCTGGACCTGTTGGACAGATATGTAAAG
TTCGTGAAAGAACGCACCGAAGTGGAACAGGCTTACGCCAAACAACTGCGGAGCCTGGTGAAAAAATATCTGCCCAAGAGACCTGCCAAG
GATGATCCTGAGTCCAAATTCAGCCAGCAACAGTCCTTCGTACAGATTCTCCAGGAGGTGAATGACTTTGCAGGCCAGCGGGAGCTGGTG
GCTGAGAACCTCAGTGTCCGTGTATGTCTTGAGCTGACCAAGTACTCACAAGAGATGAAACAGGAGAGGAAGATGCACTTCCAAGAAGGG
CGGCGGGCCCAGCAGCAGCTGGAAAATGGCTTTAAACAGCTGGAGAATAGTAAGCGTAAATTTGAGCGGGACTGCCGGGAGGCAGAGAAG
GCAGCCCAGACTGCTGAACGGCTAGACCAGGATATCAACGCCACCAAGGCTGATGTGGAGAAGGCCAAGCAGCAAGCCCACCTTCGGAGT
CACATGGCCGAAGAAAGCAAAAACGAATATGCGGCTCAACTGCAGCGCTTCAACCGAGACCAAGCCCACTTCTATTTTTCACAGATGCCC
CAGATATTCGATAAGCTCCAAGACATGGATGAACGCAGGGCCACCCGCCTGGGTGCCGGGTATGGGCTCCTGTCGGAGGCCGAGCTGGAG
GTGGTGCCCATAATAGCCAAGTGCTTGGAGGGCATGAAGGTGGCTGCAAATGCTGTGGATCCCAAGAACGACTCCCACGTCCTTATAGAG
CTGCACAAGTCAGGTTTTGCCCGCCCGGGCGACGTGGAATTCGAGGACTTCAGCCAGCCCATGAACCGTGCACCCTCCGACAGCAGTCTG
GGCACCCCCTCGGATGGACGGCCTGAACTCCGAGGCCCGGGTCGCAGCCGCACCAAGCGCTGGCCTTTTGGCAAGAAGAACAAGACAGTG
GTGACCGAGGATTTTAGCCACTTGCCCCCAGAGCAGCAGCGAAAACGGCTTCAACAGCAGTTGGAAGAACGCAGTCGTGAACTTCAGAAG
GAGGTTGACCAGAGGGAAGCCCTAAAGAAAATGAAGGATGTCTATGAGAAGACACCTCAGATGGGGGACCCCGCCAGCTTGGAGCCCCAG
ATCGCTGAAACCCTGAGCAACATTGAACGGCTGAAATTGGAAGTGCAGAAGTATGAGGCGTGGCTGGCAGAAGCTGAAAGTCGAGTCCTT
AGCAACCGGGGAGACAGCCTGAGCCGGCACGCCCGGCCTCCCGACCCCCCCGCTAGCGCCCCGCCAGACAGCAGCAGCAACAGCGCATCA
CAGGACACCAAGGAGAGCTCTGAAGAGCCTCCCTCAGAAGAGAGCCAGGACACCCCCATTTACACGGAGTTTGATGAGGATTTCGAGGAG
GAACCCACATCCCCCATAGGTCACTGTGTGGCCATCTACCACTTTGAAGCCCACAAGAGTGAACAGATACTGAAAGCGGCCAGTCTCCAG
GTTCCCAGGCCCAGCCCTGGCCACCATCATCCACCTGCTGTCAAAGAGATGAAGGAGACTCAGACAGAGAGAGACATCCCAATGTCTGAT
TCCCTTTACAGGCATGACAGCGACACACCCTCAGATAGCTTGGATAGCTCCTGCAGTTCGCCTCCTGCCTGCCAGGCCACAGAGGATGTG
GATTACACACAAGTCGTCTTTTCTGACCCTGGAGAACTAAAAAATGACTCCCCGCTGGACTATGAGAACATAAAGGAAATCACAGATTAT
GTCAATGTCAATCCAGAAAGACACAAGCCCAGTTTCTGGTATTTTGTCAACCCTGCTCTGTCTGAGCCAGCGGAATATGATCAAGTGGCC
ATGTGAATTCCAAATATTTTTAATGGGGTCCAGTTCTCTATGGATTCTTACATTTAATTTGTAGGGAAATGCCATTTTTCCCCCTTAAAC
AAGGCATGGGGCTCACAAGTCTATGGAGACAGGCCAAAAAGAATGTGGAGAAGAAAACTGATAAATACACAGAGGTCCTCAAGACCCATG
GACTCCTGGTCTGTACCCAAAAAAGCTGTTCGTTCCTCAAAAACAAAAACAAGGCTTGGCTGGGAAAACAGGCCAATGCCCCGGCAAGAA
AGGTTGAGATCAGATGTTAGGAAGAACTTTCAGGTAAAGTATGAGAACTATGGAGTCCATCAGCAGAGATAGTAGTGAAGTCTCTCCCCA
GGGAAAATTTTAAAAAGGTTGAATCAGCTGTTGTAGAGTTCTATTTGGCAATCTCATGGTTAAATGACTTCCCTTTGAGCTCTTTAATTA

>94227_94227_3_TRIP10-C1orf186_TRIP10_chr19_6750644_ENST00000596758_C1orf186_chr1_206241676_ENST00000331555_length(amino acids)=631AA_BP=496
MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQQSFVQILQEVNDFAGQRELV
AENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRS
HMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIE
LHKSGFARPGDVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKTVVTEDFSHLPPEQQRKRLQQQLEERSRELQK
EVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSAS
QDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKETQTERDIPMSD
SLYRHDSDTPSDSLDSSCSSPPACQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVNPALSEPAEYDQVA

--------------------------------------------------------------
>94227_94227_4_TRIP10-C1orf186_TRIP10_chr19_6750644_ENST00000600428_C1orf186_chr1_206241676_ENST00000331555_length(transcript)=2725nt_BP=1811nt
AATGCAGCGGGAGCAGACAAGGGCCACAAAGCATTAAATAAACTACCTTTCCCAGTATCCCCAAGGACGGACTTCCTCTTCTTGAGCCAG
GGATGTGGCTCCCAGCCAGAGCTGAGGCTTTTGGTAAACACACGCATCTGTTCAGGCCTGACCTGTTTTCCTAATCTTCCTGGTCCACAG
AGAGGCCTAAAGCTGGCCTCAGGTTAAAGTTTGACCCTAGGATGACCTATGACCCCAGGCTGAGACCCCAGCCTTAGGCTAAGCCTTTTA
TTCCAGAGTGAGGCAATTGGAGCCCCACCCCCAGATTCCAGGCTAGACCGGACTCCGGGCTGAACTCTGACCCCAGGATCAGTTCGAGGT
GCTCGAGCGCCACACGCAGTGGGGGCTGGACCTGTTGGACAGATATGTAAAGTTCGTGAAAGAACGCACCGAAGTGGAACAGGCTTACGC
CAAACAACTGCGGAGCCTGGTGAAAAAATATCTGCCCAAGAGACCTGCCAAGGATGATCCTGAGTCCAAATTCAGCCAGCAACAGTCCTT
CGTACAGATTCTCCAGGAGGTGAATGACTTTGCAGGCCAGCGGGAGCTGGTGGCTGAGAACCTCAGTGTCCGTGTATGTCTTGAGCTGAC
CAAGTACTCACAAGAGATGAAACAGGAGAGGAAGATGCACTTCCAAGAAGGGCGGCGGGCCCAGCAGCAGCTGGAAAATGGCTTTAAACA
GCTGGAGAATAGTAAGCGTAAATTTGAGCGGGACTGCCGGGAGGCAGAGAAGGCAGCCCAGACTGCTGAACGGCTAGACCAGGATATCAA
CGCCACCAAGGCTGATGTGGAGAAGGCCAAGCAGCAAGCCCACCTTCGGAGTCACATGGCCGAAGAAAGCAAAAACGAATATGCGGCTCA
ACTGCAGCGCTTCAACCGAGACCAAGCCCACTTCTATTTTTCACAGATGCCCCAGATATTCGATAAGCTCCAAGACATGGATGAACGCAG
GGCCACCCGCCTGGGTGCCGGGTATGGGCTCCTGTCGGAGGCCGAGCTGGAGGTGGTGCCCATAATAGCCAAGTGCTTGGAGGGCATGAA
GGTGGCTGCAAATGCTGTGGATCCCAAGAACGACTCCCACGTCCTTATAGAGCTGCACAAGTCAGGTTTTGCCCGCCCGGGCGACGTGGA
ATTCGAGGACTTCAGCCAGCCCATGAACCGTGCACCCTCCGACAGCAGTCTGGGCACCCCCTCGGATGGACGGCCTGAACTCCGAGGCCC
GGGTCGCAGCCGCACCAAGCGCTGGCCTTTTGGCAAGAAGAACAAGACAGTGGTGACCGAGGATTTTAGCCACTTGCCCCCAGAGCAGCA
GCGAAAACGGCTTCAACAGCAGTTGGAAGAACGCAGTCGTGAACTTCAGAAGGAGGTTGACCAGAGGGAAGCCCTAAAGAAAATGAAGGA
TGTCTATGAGAAGACACCTCAGATGGGGGACCCCGCCAGCTTGGAGCCCCAGATCGCTGAAACCCTGAGCAACATTGAACGGCTGAAATT
GGAAGTGCAGAAGTATGAGGCGTGGCTGGCAGAAGCTGAAAGTCGAGTCCTTAGCAACCGGGGAGACAGCCTGAGCCGGCACGCCCGGCC
TCCCGACCCCCCCGCTAGCGCCCCGCCAGACAGCAGCAGCAACAGCGCATCACAGGACACCAAGGAGAGCTCTGAAGAGCCTCCCTCAGA
AGAGAGCCAGGACACCCCCATTTACACGGAGTTTGATGAGGATTTCGAGGAGGAACCCACATCCCCCATAGGTCACTGTGTGGCCATCTA
CCACTTTGAAGCCCACAAGAGTGAACAGATACTGAAAGCGGCCAGTCTCCAGGTTCCCAGGCCCAGCCCTGGCCACCATCATCCACCTGC
TGTCAAAGAGATGAAGGAGACTCAGACAGAGAGAGACATCCCAATGTCTGATTCCCTTTACAGGCATGACAGCGACACACCCTCAGATAG
CTTGGATAGCTCCTGCAGTTCGCCTCCTGCCTGCCAGGCCACAGAGGATGTGGATTACACACAAGTCGTCTTTTCTGACCCTGGAGAACT
AAAAAATGACTCCCCGCTGGACTATGAGAACATAAAGGAAATCACAGATTATGTCAATGTCAATCCAGAAAGACACAAGCCCAGTTTCTG
GTATTTTGTCAACCCTGCTCTGTCTGAGCCAGCGGAATATGATCAAGTGGCCATGTGAATTCCAAATATTTTTAATGGGGTCCAGTTCTC
TATGGATTCTTACATTTAATTTGTAGGGAAATGCCATTTTTCCCCCTTAAACAAGGCATGGGGCTCACAAGTCTATGGAGACAGGCCAAA
AAGAATGTGGAGAAGAAAACTGATAAATACACAGAGGTCCTCAAGACCCATGGACTCCTGGTCTGTACCCAAAAAAGCTGTTCGTTCCTC
AAAAACAAAAACAAGGCTTGGCTGGGAAAACAGGCCAATGCCCCGGCAAGAAAGGTTGAGATCAGATGTTAGGAAGAACTTTCAGGTAAA
GTATGAGAACTATGGAGTCCATCAGCAGAGATAGTAGTGAAGTCTCTCCCCAGGGAAAATTTTAAAAAGGTTGAATCAGCTGTTGTAGAG
TTCTATTTGGCAATCTCATGGTTAAATGACTTCCCTTTGAGCTCTTTAATTATTGGCAATAAACAACTTCTTTAAAAGTTTTAAATAAAA

>94227_94227_4_TRIP10-C1orf186_TRIP10_chr19_6750644_ENST00000600428_C1orf186_chr1_206241676_ENST00000331555_length(amino acids)=610AA_BP=475
MDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQ
ERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQ
AHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPM
NRAPSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQM
GDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIY
TEFDEDFEEEPTSPIGHCVAIYHFEAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKETQTERDIPMSDSLYRHDSDTPSDSLDSSCSSP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRIP10-C1orf186


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+1415293_537552.3333333333334602.0CDC42
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+1415487_541552.3333333333334602.0DNM2 and WASL


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+1415546_601552.3333333333334602.0ARHGAP17%2C DAAM1%2C DIAPH1 and DIAPH2
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+1314546_601496.3333333333333546.0ARHGAP17%2C DAAM1%2C DIAPH1 and DIAPH2
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+1314293_537496.3333333333333546.0CDC42
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+1415529_601552.3333333333334602.0DNM1 and WASL
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+1314529_601496.3333333333333546.0DNM1 and WASL
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+1314487_541496.3333333333333546.0DNM2 and WASL
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+1415293_601552.3333333333334602.0PDE6G
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+1314293_601496.3333333333333546.0PDE6G
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313244+1415544_601552.3333333333334602.0WAS
HgeneTRIP10chr19:6750644chr1:206241676ENST00000313285+1314544_601496.3333333333333546.0WAS


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIP10-C1orf186


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIP10-C1orf186


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource