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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRMU-ST13 (FusionGDB2 ID:94319)

Fusion Gene Summary for TRMU-ST13

check button Fusion gene summary
Fusion gene informationFusion gene name: TRMU-ST13
Fusion gene ID: 94319
HgeneTgene
Gene symbol

TRMU

ST13

Gene ID

55687

6767

Gene nametRNA 5-methylaminomethyl-2-thiouridylate methyltransferaseST13 Hsp70 interacting protein
SynonymsLCAL3|MTO2|MTU1|TRMT|TRMT1AAG2|FAM10A1|FAM10A4|HIP|HOP|HSPABP|HSPABP1|P48|PRO0786|SNC6
Cytomap

22q13.31

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial tRNA-specific 2-thiouridylase 1MTO2 homologlung cancer associated lncRNA 3mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferasehsc70-interacting proteinHsp70-interacting proteinaging-associated protein 2heat shock 70kD protein binding proteinprogesterone receptor-associated p48 proteinputative tumor suppressor ST13renal carcinoma antigen NY-REN-33suppression of tumorigenic
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000424260, ENST00000290846, 
ENST00000381019, ENST00000476901, 
ENST00000216218, 
Fusion gene scores* DoF score11 X 8 X 10=8809 X 8 X 6=432
# samples 1613
** MAII scorelog2(16/880*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/432*10)=-1.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRMU [Title/Abstract] AND ST13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRMU(46748227)-ST13(41231891), # samples:2
TRMU(46749764)-ST13(41231891), # samples:2
Anticipated loss of major functional domain due to fusion event.TRMU-ST13 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TRMU-ST13 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRMU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ST13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A2JC-06ATRMUchr22

46742441

+ST13chr22

41231891

-
ChimerDB4SKCMTCGA-D3-A2JC-06ATRMUchr22

46748227

+ST13chr22

41231891

-
ChimerDB4SKCMTCGA-D3-A2JC-06ATRMUchr22

46749764

+ST13chr22

41231891

-
ChimerDB4SKCMTCGA-D3-A2JCTRMUchr22

46749764

+ST13chr22

41231891

-


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Fusion Gene ORF analysis for TRMU-ST13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000424260ENST00000216218TRMUchr22

46748227

+ST13chr22

41231891

-
Frame-shiftENST00000290846ENST00000216218TRMUchr22

46749764

+ST13chr22

41231891

-
Frame-shiftENST00000381019ENST00000216218TRMUchr22

46749764

+ST13chr22

41231891

-
In-frameENST00000290846ENST00000216218TRMUchr22

46742441

+ST13chr22

41231891

-
In-frameENST00000290846ENST00000216218TRMUchr22

46748227

+ST13chr22

41231891

-
In-frameENST00000381019ENST00000216218TRMUchr22

46742441

+ST13chr22

41231891

-
In-frameENST00000381019ENST00000216218TRMUchr22

46748227

+ST13chr22

41231891

-
In-frameENST00000424260ENST00000216218TRMUchr22

46742441

+ST13chr22

41231891

-
intron-3CDSENST00000424260ENST00000216218TRMUchr22

46749764

+ST13chr22

41231891

-
intron-3CDSENST00000476901ENST00000216218TRMUchr22

46742441

+ST13chr22

41231891

-
intron-3CDSENST00000476901ENST00000216218TRMUchr22

46748227

+ST13chr22

41231891

-
intron-3CDSENST00000476901ENST00000216218TRMUchr22

46749764

+ST13chr22

41231891

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000290846TRMUchr2246748227+ENST00000216218ST13chr2241231891-384311123101839509
ENST00000381019TRMUchr2246748227+ENST00000216218ST13chr2241231891-352379251519504
ENST00000290846TRMUchr2246742441+ENST00000216218ST13chr2241231891-35498183101545411
ENST00000381019TRMUchr2246742441+ENST00000216218ST13chr2241231891-322949851225406
ENST00000424260TRMUchr2246742441+ENST00000216218ST13chr2241231891-33125812081308366

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290846ENST00000216218TRMUchr2246748227+ST13chr2241231891-0.0001359090.9998641
ENST00000381019ENST00000216218TRMUchr2246748227+ST13chr2241231891-0.0001206030.99987936
ENST00000290846ENST00000216218TRMUchr2246742441+ST13chr2241231891-0.0001108210.99988914
ENST00000381019ENST00000216218TRMUchr2246742441+ST13chr2241231891-9.82E-050.9999018
ENST00000424260ENST00000216218TRMUchr2246742441+ST13chr2241231891-0.000125770.99987423

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Fusion Genomic Features for TRMU-ST13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRMU-ST13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:46748227/chr22:41231891)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRMUchr22:46742441chr22:41231891ENST00000290846+41110_17159422.0Nucleotide bindingATP
HgeneTRMUchr22:46742441chr22:41231891ENST00000381019+41010_17159377.0Nucleotide bindingATP
HgeneTRMUchr22:46748227chr22:41231891ENST00000290846+71110_17257422.0Nucleotide bindingATP
HgeneTRMUchr22:46748227chr22:41231891ENST00000381019+71010_17257377.0Nucleotide bindingATP
TgeneST13chr22:46742441chr22:41231891ENST00000216218412279_312127370.0Compositional biasNote=Gly/Met/Pro-rich
TgeneST13chr22:46748227chr22:41231891ENST00000216218412279_312127370.0Compositional biasNote=Gly/Met/Pro-rich
TgeneST13chr22:46742441chr22:41231891ENST00000216218412319_358127370.0DomainNote=STI1
TgeneST13chr22:46748227chr22:41231891ENST00000216218412319_358127370.0DomainNote=STI1
TgeneST13chr22:46742441chr22:41231891ENST00000216218412148_181127370.0RepeatNote=TPR 2
TgeneST13chr22:46742441chr22:41231891ENST00000216218412182_215127370.0RepeatNote=TPR 3
TgeneST13chr22:46748227chr22:41231891ENST00000216218412148_181127370.0RepeatNote=TPR 2
TgeneST13chr22:46748227chr22:41231891ENST00000216218412182_215127370.0RepeatNote=TPR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneST13chr22:46742441chr22:41231891ENST00000216218412114_147127370.0RepeatNote=TPR 1
TgeneST13chr22:46748227chr22:41231891ENST00000216218412114_147127370.0RepeatNote=TPR 1


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Fusion Gene Sequence for TRMU-ST13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94319_94319_1_TRMU-ST13_TRMU_chr22_46742441_ENST00000290846_ST13_chr22_41231891_ENST00000216218_length(transcript)=3549nt_BP=818nt
GGCTGGGGGGCTTAGAATTTTATTTTTGGTTTACAGCGCAGAAGAAGAGCAGTGAGGCCGGGGCGCGGGTGGGGAGGGCAAGGCGGCGGC
TCAAAAAAAAAGCCAGCCCCTCGCGGCCCGACAGAGTCTCGGCGCCCCGCGGGTCGGTGGAGCCTCAGGGGTGAGCGCAGGCCGGAGACA
GGGGAACCCGCCGCGGGACAGGGGAAGGCCGGACGGAACGCGGGTAAGCTGCCGCAGCTTCCGGCCGGGCCACTAGCGCGGACCCTACGG
CCGGGGCGGGACTTCCGGCAAGGCGCGGAAGCGGCGGTAGCTGCAGCTGGCGAAGTTGGGCGACTGGCGGATGCAGGCCTTGCGGCACGT
CGTGTGCGCCCTGTCCGGCGGCGTGGACAGCGCCGTGGCCGCGCTGCTGCTGAGGCGGAGAGGTTACCAGGTGACAGGGGTGTTTATGAA
GAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACTGTGAAGATGCTTACAGAGTTTGCCAGATCTTAGACATCCC
TTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGTGACTTTTTGAATGAGTATGAAAAAGGAAGGACTCCCAATCC
TGACATAGTTTGCAACAAGCACATCAAATTTAGTTGCTTTTTTCATTATGCTGTGGATAATCTTGGGGCAGATGCCATTGCCACAGGTCA
CTATGCAAGAACTTCCCTGGAAGATGAAGAAGTCTTTGAGCAGAAGCACGTTAAGAAGCCCGAAGGGCTTTTCAGAAATCGGTTTGAAGT
TAGAAATGGTGAACTCCAGAAAGCCATTGACTTATTCACAGATGCCATCAAGCTGAATCCTCGCTTGGCCATTTTGTATGCCAAGAGGGC
CAGTGTCTTCGTCAAATTACAGAAGCCAAATGCTGCCATCCGAGACTGTGACAGAGCCATTGAAATAAATCCTGATTCAGCTCAGCCTTA
CAAGTGGCGGGGGAAAGCACACAGACTTCTAGGCCACTGGGAAGAAGCAGCCCATGATCTTGCCCTTGCCTGTAAATTGGATTATGATGA
AGATGCTAGTGCAATGCTGAAAGAAGTTCAACCTAGGGCACAGAAAATTGCAGAACATCGGAGAAAGTATGAGCGAAAACGTGAAGAGCG
AGAGATCAAAGAAAGAATAGAACGAGTTAAGAAGGCTCGAGAAGAGCATGAGAGAGCCCAGAGGGAGGAAGAAGCCAGACGACAGTCAGG
AGCTCAGTATGGCTCTTTTCCAGGTGGCTTTCCTGGGGGAATGCCTGGTAATTTTCCCGGAGGAATGCCTGGAATGGGAGGGGGCATGCC
TGGAATGGCTGGAATGCCTGGACTCAATGAAATTCTTAGTGATCCAGAGGTTCTTGCAGCCATGCAGGATCCAGAAGTTATGGTGGCTTT
CCAGGATGTGGCTCAGAACCCAGCAAATATGTCAAAATACCAGAGCAACCCAAAGGTTATGAATCTCATCAGTAAATTGTCAGCCAAATT
TGGAGGTCAAGCGTAATGTCCTTCTGATAAATAAAGCCCTTGCTGAAGGAAAAGCAACCTAGATCACCTTATGGATGTCGCAATAATACA
AACCAGTGTACCTCTGACCTTCTCATCAAGAGAGCTGGGGTGCTTTGAAGATAATCCCTACCCCTCTCCCCCAAATGCAGCTGAAGCATT
TTACAGTGGTTTGCCATTAGGGTATTCATTCAGATAATGTTTTCCTACTAGGAATTACAAACTTTAAACACTTTTTAAATCTTCAAAATA
TTTAAAACAAATTTAAAGGGCCTGTTAATTCTTATATTTTTCTTTACTAATCATTTTGGATTTTTTTCTTTGAATTATTGGCAGGGAATA
TACTTATGTATGGAAGATTACTGCTCTGAGTGAAATAAAAGTTATTAGTGCGAGGCAAACATAACTCATTTGAGGATAAAGTTTGTGTTG
GATATGTGGTTCCTGATGCATTTTGACTTGTCTTTTTAAATGCTTTATCTTTTTCTTTAAAGATTTATTTCAATAAAACTAATTGGGACC
ACCCGTATTTCAGTAGGACCTGGGTAGGGATTGGAAGTACTTGGCAGGGCAGCAGCAATCTTGCTGTGTTTGATATAACATGCATCCTTG
GGCAGGTTGCCCTTAAATCTTACACTGTGGTGAAGGGATGTTTTTTTTGTAATGCTGCAGTAGAGTTGGAGTACTTAGTTCTCTTGTTGT
CCAGTATATCTAATAAGTGTTTTTCATATTATTTCCACGTAAGGGAAATAAGGTAGTACTTTTCTTTTTATATTTCTATGCTTAAAATTC
TCTTTCCTAGTCAAAAATTGCCCAAATCTGTGTTTGCTTTCTGCTTGCTACATTTGTCTCCCTTACTTTTCTTGAGCTAAAGACAGGCTT
TTTCCACCGGCATCATCACTGCTATCATCATTAACAGCGTAATTATACAAGCATATTTAATGCTGAGTTTAATTTAATATGTAATACATA
TGGTAATTGTAGGGTAATACCCACAACAACTGTAGTTTCTTACTTGGCCAAGAGAATGCTTATTTAAGTGTTAGACTTCCATTCTGGCAA
AATCTTGCCTTATCAGAAGACATTGGAAAGAGGGATTCCCTTTGGTGTTTGGTCTTCTACTTAGAAAAACCTATTGCAGTTAGTTTATCT
TGTAGTATTCATCTTTGTATTCTGAAGATAAGGTTTGAATTAAATTGATACACACAGAGGGGAACCGATTTTTTTTATCCAATGTGAATT
ATAAATGAGATAATCCACAGTTATTCATTGTGGAGTTGTTGAGACTATGAAAGACTCATTGTCTTTGTATTCAGCTCTTAAATAGTGTAA
CTATATCCCCACCTCTGCTTGCTTTCTTTCCCTCCCCTCCAATGATAAAGAAAATGATAAATTTTCTGTTGTGCATTCAATTCTTATTTT
AAATAAGACTAAGTATAGGCATTGTACCTGACATTGCTACGTTTCTACCAGTGTTTCAATTTAAAGTGCTAGTGTTTAAAAACATTTTCA
AGGGATAAGGCCTTCTGTACTTTGCTTATTTGAAGAATCAGTGGTAGGAGCAGTGAAGTAAATTCTATGGAGTACATTTCTAAAATACCA
CATTTCTGAAATCATAAATAAGTTTATTCAGGTTCTAACCCTTTGCTGTACACAAGCAGACAGAAATGCATCTGTTACATAAATGAGAAA
AAGCTATTATGCTGATGGAGCATGCTTTTTAAATCCTTTAAAAACACTCACCATATAAACTTGCATTTGAGCTTGTGTGTTCTTTTGTTA
ATGTGTAGAGTTCTCCTTTCTCGAAATTGCCAGTGTGTACTTGGCTTAACTCAAGAACAGTTTCTTCTGGATTCCTTATTTGATTTATTT
AACCTAATTATATTCTAATATTGCAAATATTACCATAAGTGGGTAAAAGTAAAATTCCTCTTCTGAAAATGTGTCCTGTGCTTTTAGATT

>94319_94319_1_TRMU-ST13_TRMU_chr22_46742441_ENST00000290846_ST13_chr22_41231891_ENST00000216218_length(amino acids)=411AA_BP=169
MQLAKLGDWRMQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWND
VFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNGELQKAIDLFT
DAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKEVQPRA
QKIAEHRRKYERKREEREIKERIERVKKAREEHERAQREEEARRQSGAQYGSFPGGFPGGMPGNFPGGMPGMGGGMPGMAGMPGLNEILS

--------------------------------------------------------------
>94319_94319_2_TRMU-ST13_TRMU_chr22_46742441_ENST00000381019_ST13_chr22_41231891_ENST00000216218_length(transcript)=3229nt_BP=498nt
CGAAGTTGGGCGACTGGCGGATGCAGGCCTTGCGGCACGTCGTGTGCGCCCTGTCCGGCGGCGTGGACAGCGCCGTGGCCGCGCTGCTGC
TGAGGCGGAGAGGTTACCAGGTGACAGGGGTGTTTATGAAGAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACT
GTGAAGATGCTTACAGAGTTTGCCAGATCTTAGACATCCCTTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGTG
ACTTTTTGAATGAGTATGAAAAAGGAAGGACTCCCAATCCTGACATAGTTTGCAACAAGCACATCAAATTTAGTTGCTTTTTTCATTATG
CTGTGGATAATCTTGGGGCAGATGCCATTGCCACAGGTCACTATGCAAGAACTTCCCTGGAAGATGAAGAAGTCTTTGAGCAGAAGCACG
TTAAGAAGCCCGAAGGGCTTTTCAGAAATCGGTTTGAAGTTAGAAATGGTGAACTCCAGAAAGCCATTGACTTATTCACAGATGCCATCA
AGCTGAATCCTCGCTTGGCCATTTTGTATGCCAAGAGGGCCAGTGTCTTCGTCAAATTACAGAAGCCAAATGCTGCCATCCGAGACTGTG
ACAGAGCCATTGAAATAAATCCTGATTCAGCTCAGCCTTACAAGTGGCGGGGGAAAGCACACAGACTTCTAGGCCACTGGGAAGAAGCAG
CCCATGATCTTGCCCTTGCCTGTAAATTGGATTATGATGAAGATGCTAGTGCAATGCTGAAAGAAGTTCAACCTAGGGCACAGAAAATTG
CAGAACATCGGAGAAAGTATGAGCGAAAACGTGAAGAGCGAGAGATCAAAGAAAGAATAGAACGAGTTAAGAAGGCTCGAGAAGAGCATG
AGAGAGCCCAGAGGGAGGAAGAAGCCAGACGACAGTCAGGAGCTCAGTATGGCTCTTTTCCAGGTGGCTTTCCTGGGGGAATGCCTGGTA
ATTTTCCCGGAGGAATGCCTGGAATGGGAGGGGGCATGCCTGGAATGGCTGGAATGCCTGGACTCAATGAAATTCTTAGTGATCCAGAGG
TTCTTGCAGCCATGCAGGATCCAGAAGTTATGGTGGCTTTCCAGGATGTGGCTCAGAACCCAGCAAATATGTCAAAATACCAGAGCAACC
CAAAGGTTATGAATCTCATCAGTAAATTGTCAGCCAAATTTGGAGGTCAAGCGTAATGTCCTTCTGATAAATAAAGCCCTTGCTGAAGGA
AAAGCAACCTAGATCACCTTATGGATGTCGCAATAATACAAACCAGTGTACCTCTGACCTTCTCATCAAGAGAGCTGGGGTGCTTTGAAG
ATAATCCCTACCCCTCTCCCCCAAATGCAGCTGAAGCATTTTACAGTGGTTTGCCATTAGGGTATTCATTCAGATAATGTTTTCCTACTA
GGAATTACAAACTTTAAACACTTTTTAAATCTTCAAAATATTTAAAACAAATTTAAAGGGCCTGTTAATTCTTATATTTTTCTTTACTAA
TCATTTTGGATTTTTTTCTTTGAATTATTGGCAGGGAATATACTTATGTATGGAAGATTACTGCTCTGAGTGAAATAAAAGTTATTAGTG
CGAGGCAAACATAACTCATTTGAGGATAAAGTTTGTGTTGGATATGTGGTTCCTGATGCATTTTGACTTGTCTTTTTAAATGCTTTATCT
TTTTCTTTAAAGATTTATTTCAATAAAACTAATTGGGACCACCCGTATTTCAGTAGGACCTGGGTAGGGATTGGAAGTACTTGGCAGGGC
AGCAGCAATCTTGCTGTGTTTGATATAACATGCATCCTTGGGCAGGTTGCCCTTAAATCTTACACTGTGGTGAAGGGATGTTTTTTTTGT
AATGCTGCAGTAGAGTTGGAGTACTTAGTTCTCTTGTTGTCCAGTATATCTAATAAGTGTTTTTCATATTATTTCCACGTAAGGGAAATA
AGGTAGTACTTTTCTTTTTATATTTCTATGCTTAAAATTCTCTTTCCTAGTCAAAAATTGCCCAAATCTGTGTTTGCTTTCTGCTTGCTA
CATTTGTCTCCCTTACTTTTCTTGAGCTAAAGACAGGCTTTTTCCACCGGCATCATCACTGCTATCATCATTAACAGCGTAATTATACAA
GCATATTTAATGCTGAGTTTAATTTAATATGTAATACATATGGTAATTGTAGGGTAATACCCACAACAACTGTAGTTTCTTACTTGGCCA
AGAGAATGCTTATTTAAGTGTTAGACTTCCATTCTGGCAAAATCTTGCCTTATCAGAAGACATTGGAAAGAGGGATTCCCTTTGGTGTTT
GGTCTTCTACTTAGAAAAACCTATTGCAGTTAGTTTATCTTGTAGTATTCATCTTTGTATTCTGAAGATAAGGTTTGAATTAAATTGATA
CACACAGAGGGGAACCGATTTTTTTTATCCAATGTGAATTATAAATGAGATAATCCACAGTTATTCATTGTGGAGTTGTTGAGACTATGA
AAGACTCATTGTCTTTGTATTCAGCTCTTAAATAGTGTAACTATATCCCCACCTCTGCTTGCTTTCTTTCCCTCCCCTCCAATGATAAAG
AAAATGATAAATTTTCTGTTGTGCATTCAATTCTTATTTTAAATAAGACTAAGTATAGGCATTGTACCTGACATTGCTACGTTTCTACCA
GTGTTTCAATTTAAAGTGCTAGTGTTTAAAAACATTTTCAAGGGATAAGGCCTTCTGTACTTTGCTTATTTGAAGAATCAGTGGTAGGAG
CAGTGAAGTAAATTCTATGGAGTACATTTCTAAAATACCACATTTCTGAAATCATAAATAAGTTTATTCAGGTTCTAACCCTTTGCTGTA
CACAAGCAGACAGAAATGCATCTGTTACATAAATGAGAAAAAGCTATTATGCTGATGGAGCATGCTTTTTAAATCCTTTAAAAACACTCA
CCATATAAACTTGCATTTGAGCTTGTGTGTTCTTTTGTTAATGTGTAGAGTTCTCCTTTCTCGAAATTGCCAGTGTGTACTTGGCTTAAC
TCAAGAACAGTTTCTTCTGGATTCCTTATTTGATTTATTTAACCTAATTATATTCTAATATTGCAAATATTACCATAAGTGGGTAAAAGT

>94319_94319_2_TRMU-ST13_TRMU_chr22_46742441_ENST00000381019_ST13_chr22_41231891_ENST00000216218_length(amino acids)=406AA_BP=164
MGDWRMQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDF
LNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNGELQKAIDLFTDAIKL
NPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKEVQPRAQKIAE
HRRKYERKREEREIKERIERVKKAREEHERAQREEEARRQSGAQYGSFPGGFPGGMPGNFPGGMPGMGGGMPGMAGMPGLNEILSDPEVL

--------------------------------------------------------------
>94319_94319_3_TRMU-ST13_TRMU_chr22_46742441_ENST00000424260_ST13_chr22_41231891_ENST00000216218_length(transcript)=3312nt_BP=581nt
GTGCACGTCTCCTCCCTCCCTGGGCCGCTGGTTGCGCGCGGGTCGGCAGGAGGATACCCCGTCCTCTGACTTTGGTTCGGAGGCTCCTCG
CCCTCCACCTGTGTAGTCGGAGGTGTGCGCGACTGCAGCTCCGACTACCTGGGAGCAGTTCCGCGCCCCTCTCCACCCACGCGCGCCCAC
CCACAGTTACCAGGTGACAGGGGTGTTTATGAAGAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACTGTGAAGA
TGCTTACAGAGTTTGCCAGATCTTAGACATCCCTTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGTGACTTTTT
GAATGAGTATGAAAAAGGAAGGACTCCCAATCCTGACATAGTTTGCAACAAGCACATCAAATTTAGTTGCTTTTTTCATTATGCTGTGGA
TAATCTTGGGGCAGATGCCATTGCCACAGGTCACTATGCAAGAACTTCCCTGGAAGATGAAGAAGTCTTTGAGCAGAAGCACGTTAAGAA
GCCCGAAGGGCTTTTCAGAAATCGGTTTGAAGTTAGAAATGGTGAACTCCAGAAAGCCATTGACTTATTCACAGATGCCATCAAGCTGAA
TCCTCGCTTGGCCATTTTGTATGCCAAGAGGGCCAGTGTCTTCGTCAAATTACAGAAGCCAAATGCTGCCATCCGAGACTGTGACAGAGC
CATTGAAATAAATCCTGATTCAGCTCAGCCTTACAAGTGGCGGGGGAAAGCACACAGACTTCTAGGCCACTGGGAAGAAGCAGCCCATGA
TCTTGCCCTTGCCTGTAAATTGGATTATGATGAAGATGCTAGTGCAATGCTGAAAGAAGTTCAACCTAGGGCACAGAAAATTGCAGAACA
TCGGAGAAAGTATGAGCGAAAACGTGAAGAGCGAGAGATCAAAGAAAGAATAGAACGAGTTAAGAAGGCTCGAGAAGAGCATGAGAGAGC
CCAGAGGGAGGAAGAAGCCAGACGACAGTCAGGAGCTCAGTATGGCTCTTTTCCAGGTGGCTTTCCTGGGGGAATGCCTGGTAATTTTCC
CGGAGGAATGCCTGGAATGGGAGGGGGCATGCCTGGAATGGCTGGAATGCCTGGACTCAATGAAATTCTTAGTGATCCAGAGGTTCTTGC
AGCCATGCAGGATCCAGAAGTTATGGTGGCTTTCCAGGATGTGGCTCAGAACCCAGCAAATATGTCAAAATACCAGAGCAACCCAAAGGT
TATGAATCTCATCAGTAAATTGTCAGCCAAATTTGGAGGTCAAGCGTAATGTCCTTCTGATAAATAAAGCCCTTGCTGAAGGAAAAGCAA
CCTAGATCACCTTATGGATGTCGCAATAATACAAACCAGTGTACCTCTGACCTTCTCATCAAGAGAGCTGGGGTGCTTTGAAGATAATCC
CTACCCCTCTCCCCCAAATGCAGCTGAAGCATTTTACAGTGGTTTGCCATTAGGGTATTCATTCAGATAATGTTTTCCTACTAGGAATTA
CAAACTTTAAACACTTTTTAAATCTTCAAAATATTTAAAACAAATTTAAAGGGCCTGTTAATTCTTATATTTTTCTTTACTAATCATTTT
GGATTTTTTTCTTTGAATTATTGGCAGGGAATATACTTATGTATGGAAGATTACTGCTCTGAGTGAAATAAAAGTTATTAGTGCGAGGCA
AACATAACTCATTTGAGGATAAAGTTTGTGTTGGATATGTGGTTCCTGATGCATTTTGACTTGTCTTTTTAAATGCTTTATCTTTTTCTT
TAAAGATTTATTTCAATAAAACTAATTGGGACCACCCGTATTTCAGTAGGACCTGGGTAGGGATTGGAAGTACTTGGCAGGGCAGCAGCA
ATCTTGCTGTGTTTGATATAACATGCATCCTTGGGCAGGTTGCCCTTAAATCTTACACTGTGGTGAAGGGATGTTTTTTTTGTAATGCTG
CAGTAGAGTTGGAGTACTTAGTTCTCTTGTTGTCCAGTATATCTAATAAGTGTTTTTCATATTATTTCCACGTAAGGGAAATAAGGTAGT
ACTTTTCTTTTTATATTTCTATGCTTAAAATTCTCTTTCCTAGTCAAAAATTGCCCAAATCTGTGTTTGCTTTCTGCTTGCTACATTTGT
CTCCCTTACTTTTCTTGAGCTAAAGACAGGCTTTTTCCACCGGCATCATCACTGCTATCATCATTAACAGCGTAATTATACAAGCATATT
TAATGCTGAGTTTAATTTAATATGTAATACATATGGTAATTGTAGGGTAATACCCACAACAACTGTAGTTTCTTACTTGGCCAAGAGAAT
GCTTATTTAAGTGTTAGACTTCCATTCTGGCAAAATCTTGCCTTATCAGAAGACATTGGAAAGAGGGATTCCCTTTGGTGTTTGGTCTTC
TACTTAGAAAAACCTATTGCAGTTAGTTTATCTTGTAGTATTCATCTTTGTATTCTGAAGATAAGGTTTGAATTAAATTGATACACACAG
AGGGGAACCGATTTTTTTTATCCAATGTGAATTATAAATGAGATAATCCACAGTTATTCATTGTGGAGTTGTTGAGACTATGAAAGACTC
ATTGTCTTTGTATTCAGCTCTTAAATAGTGTAACTATATCCCCACCTCTGCTTGCTTTCTTTCCCTCCCCTCCAATGATAAAGAAAATGA
TAAATTTTCTGTTGTGCATTCAATTCTTATTTTAAATAAGACTAAGTATAGGCATTGTACCTGACATTGCTACGTTTCTACCAGTGTTTC
AATTTAAAGTGCTAGTGTTTAAAAACATTTTCAAGGGATAAGGCCTTCTGTACTTTGCTTATTTGAAGAATCAGTGGTAGGAGCAGTGAA
GTAAATTCTATGGAGTACATTTCTAAAATACCACATTTCTGAAATCATAAATAAGTTTATTCAGGTTCTAACCCTTTGCTGTACACAAGC
AGACAGAAATGCATCTGTTACATAAATGAGAAAAAGCTATTATGCTGATGGAGCATGCTTTTTAAATCCTTTAAAAACACTCACCATATA
AACTTGCATTTGAGCTTGTGTGTTCTTTTGTTAATGTGTAGAGTTCTCCTTTCTCGAAATTGCCAGTGTGTACTTGGCTTAACTCAAGAA
CAGTTTCTTCTGGATTCCTTATTTGATTTATTTAACCTAATTATATTCTAATATTGCAAATATTACCATAAGTGGGTAAAAGTAAAATTC

>94319_94319_3_TRMU-ST13_TRMU_chr22_46742441_ENST00000424260_ST13_chr22_41231891_ENST00000216218_length(amino acids)=366AA_BP=124
MKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIAT
GHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQ
PYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKEVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHERAQREEEARRQ
SGAQYGSFPGGFPGGMPGNFPGGMPGMGGGMPGMAGMPGLNEILSDPEVLAAMQDPEVMVAFQDVAQNPANMSKYQSNPKVMNLISKLSA

--------------------------------------------------------------
>94319_94319_4_TRMU-ST13_TRMU_chr22_46748227_ENST00000290846_ST13_chr22_41231891_ENST00000216218_length(transcript)=3843nt_BP=1112nt
GGCTGGGGGGCTTAGAATTTTATTTTTGGTTTACAGCGCAGAAGAAGAGCAGTGAGGCCGGGGCGCGGGTGGGGAGGGCAAGGCGGCGGC
TCAAAAAAAAAGCCAGCCCCTCGCGGCCCGACAGAGTCTCGGCGCCCCGCGGGTCGGTGGAGCCTCAGGGGTGAGCGCAGGCCGGAGACA
GGGGAACCCGCCGCGGGACAGGGGAAGGCCGGACGGAACGCGGGTAAGCTGCCGCAGCTTCCGGCCGGGCCACTAGCGCGGACCCTACGG
CCGGGGCGGGACTTCCGGCAAGGCGCGGAAGCGGCGGTAGCTGCAGCTGGCGAAGTTGGGCGACTGGCGGATGCAGGCCTTGCGGCACGT
CGTGTGCGCCCTGTCCGGCGGCGTGGACAGCGCCGTGGCCGCGCTGCTGCTGAGGCGGAGAGGTTACCAGGTGACAGGGGTGTTTATGAA
GAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACTGTGAAGATGCTTACAGAGTTTGCCAGATCTTAGACATCCC
TTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGTGACTTTTTGAATGAGTATGAAAAAGGAAGGACTCCCAATCC
TGACATAGTTTGCAACAAGCACATCAAATTTAGTTGCTTTTTTCATTATGCTGTGGATAATCTTGGGGCAGATGCCATTGCCACAGGTCA
CTATGCAAGAACTTCCCTGGAAGATGAAGAAGTCTTTGAGCAGAAGCACGTTAAGAAGCCCGAAGGGCTTTTCAGAAATCGGTTTGAAGT
TAGAAATGCGGTAAAACTCCTCCAGGCAGCTGACAGCTTTAAAGACCAGACCTTCTTTCTCAGCCAGGTTTCCCAGGATGCCCTGAGGAG
AACCATCTTCCCTCTGGGGGGATTAACGAAAGAGTTTGTAAAGAAAATCGCTGCTGAGAATAGACTTCATCATGTGCTTCAGAAGAAAGA
GAGCATGGGCATGTGTTTCATCGGGAAGAGGAATTTTGAACATTTCCTTCTTCAGTATCTGCAGCCTCGACCTGGTCACTTTATTTCCAT
AGAAGACAATAAGGTTCTGGGAACACATAAAGGTGAACTCCAGAAAGCCATTGACTTATTCACAGATGCCATCAAGCTGAATCCTCGCTT
GGCCATTTTGTATGCCAAGAGGGCCAGTGTCTTCGTCAAATTACAGAAGCCAAATGCTGCCATCCGAGACTGTGACAGAGCCATTGAAAT
AAATCCTGATTCAGCTCAGCCTTACAAGTGGCGGGGGAAAGCACACAGACTTCTAGGCCACTGGGAAGAAGCAGCCCATGATCTTGCCCT
TGCCTGTAAATTGGATTATGATGAAGATGCTAGTGCAATGCTGAAAGAAGTTCAACCTAGGGCACAGAAAATTGCAGAACATCGGAGAAA
GTATGAGCGAAAACGTGAAGAGCGAGAGATCAAAGAAAGAATAGAACGAGTTAAGAAGGCTCGAGAAGAGCATGAGAGAGCCCAGAGGGA
GGAAGAAGCCAGACGACAGTCAGGAGCTCAGTATGGCTCTTTTCCAGGTGGCTTTCCTGGGGGAATGCCTGGTAATTTTCCCGGAGGAAT
GCCTGGAATGGGAGGGGGCATGCCTGGAATGGCTGGAATGCCTGGACTCAATGAAATTCTTAGTGATCCAGAGGTTCTTGCAGCCATGCA
GGATCCAGAAGTTATGGTGGCTTTCCAGGATGTGGCTCAGAACCCAGCAAATATGTCAAAATACCAGAGCAACCCAAAGGTTATGAATCT
CATCAGTAAATTGTCAGCCAAATTTGGAGGTCAAGCGTAATGTCCTTCTGATAAATAAAGCCCTTGCTGAAGGAAAAGCAACCTAGATCA
CCTTATGGATGTCGCAATAATACAAACCAGTGTACCTCTGACCTTCTCATCAAGAGAGCTGGGGTGCTTTGAAGATAATCCCTACCCCTC
TCCCCCAAATGCAGCTGAAGCATTTTACAGTGGTTTGCCATTAGGGTATTCATTCAGATAATGTTTTCCTACTAGGAATTACAAACTTTA
AACACTTTTTAAATCTTCAAAATATTTAAAACAAATTTAAAGGGCCTGTTAATTCTTATATTTTTCTTTACTAATCATTTTGGATTTTTT
TCTTTGAATTATTGGCAGGGAATATACTTATGTATGGAAGATTACTGCTCTGAGTGAAATAAAAGTTATTAGTGCGAGGCAAACATAACT
CATTTGAGGATAAAGTTTGTGTTGGATATGTGGTTCCTGATGCATTTTGACTTGTCTTTTTAAATGCTTTATCTTTTTCTTTAAAGATTT
ATTTCAATAAAACTAATTGGGACCACCCGTATTTCAGTAGGACCTGGGTAGGGATTGGAAGTACTTGGCAGGGCAGCAGCAATCTTGCTG
TGTTTGATATAACATGCATCCTTGGGCAGGTTGCCCTTAAATCTTACACTGTGGTGAAGGGATGTTTTTTTTGTAATGCTGCAGTAGAGT
TGGAGTACTTAGTTCTCTTGTTGTCCAGTATATCTAATAAGTGTTTTTCATATTATTTCCACGTAAGGGAAATAAGGTAGTACTTTTCTT
TTTATATTTCTATGCTTAAAATTCTCTTTCCTAGTCAAAAATTGCCCAAATCTGTGTTTGCTTTCTGCTTGCTACATTTGTCTCCCTTAC
TTTTCTTGAGCTAAAGACAGGCTTTTTCCACCGGCATCATCACTGCTATCATCATTAACAGCGTAATTATACAAGCATATTTAATGCTGA
GTTTAATTTAATATGTAATACATATGGTAATTGTAGGGTAATACCCACAACAACTGTAGTTTCTTACTTGGCCAAGAGAATGCTTATTTA
AGTGTTAGACTTCCATTCTGGCAAAATCTTGCCTTATCAGAAGACATTGGAAAGAGGGATTCCCTTTGGTGTTTGGTCTTCTACTTAGAA
AAACCTATTGCAGTTAGTTTATCTTGTAGTATTCATCTTTGTATTCTGAAGATAAGGTTTGAATTAAATTGATACACACAGAGGGGAACC
GATTTTTTTTATCCAATGTGAATTATAAATGAGATAATCCACAGTTATTCATTGTGGAGTTGTTGAGACTATGAAAGACTCATTGTCTTT
GTATTCAGCTCTTAAATAGTGTAACTATATCCCCACCTCTGCTTGCTTTCTTTCCCTCCCCTCCAATGATAAAGAAAATGATAAATTTTC
TGTTGTGCATTCAATTCTTATTTTAAATAAGACTAAGTATAGGCATTGTACCTGACATTGCTACGTTTCTACCAGTGTTTCAATTTAAAG
TGCTAGTGTTTAAAAACATTTTCAAGGGATAAGGCCTTCTGTACTTTGCTTATTTGAAGAATCAGTGGTAGGAGCAGTGAAGTAAATTCT
ATGGAGTACATTTCTAAAATACCACATTTCTGAAATCATAAATAAGTTTATTCAGGTTCTAACCCTTTGCTGTACACAAGCAGACAGAAA
TGCATCTGTTACATAAATGAGAAAAAGCTATTATGCTGATGGAGCATGCTTTTTAAATCCTTTAAAAACACTCACCATATAAACTTGCAT
TTGAGCTTGTGTGTTCTTTTGTTAATGTGTAGAGTTCTCCTTTCTCGAAATTGCCAGTGTGTACTTGGCTTAACTCAAGAACAGTTTCTT
CTGGATTCCTTATTTGATTTATTTAACCTAATTATATTCTAATATTGCAAATATTACCATAAGTGGGTAAAAGTAAAATTCCTCTTCTGA

>94319_94319_4_TRMU-ST13_TRMU_chr22_46748227_ENST00000290846_ST13_chr22_41231891_ENST00000216218_length(amino acids)=509AA_BP=267
MQLAKLGDWRMQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWND
VFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNAVKLLQAADSF
KDQTFFLSQVSQDALRRTIFPLGGLTKEFVKKIAAENRLHHVLQKKESMGMCFIGKRNFEHFLLQYLQPRPGHFISIEDNKVLGTHKGEL
QKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAM
LKEVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHERAQREEEARRQSGAQYGSFPGGFPGGMPGNFPGGMPGMGGGMPGMAGM

--------------------------------------------------------------
>94319_94319_5_TRMU-ST13_TRMU_chr22_46748227_ENST00000381019_ST13_chr22_41231891_ENST00000216218_length(transcript)=3523nt_BP=792nt
CGAAGTTGGGCGACTGGCGGATGCAGGCCTTGCGGCACGTCGTGTGCGCCCTGTCCGGCGGCGTGGACAGCGCCGTGGCCGCGCTGCTGC
TGAGGCGGAGAGGTTACCAGGTGACAGGGGTGTTTATGAAGAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACT
GTGAAGATGCTTACAGAGTTTGCCAGATCTTAGACATCCCTTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGTG
ACTTTTTGAATGAGTATGAAAAAGGAAGGACTCCCAATCCTGACATAGTTTGCAACAAGCACATCAAATTTAGTTGCTTTTTTCATTATG
CTGTGGATAATCTTGGGGCAGATGCCATTGCCACAGGTCACTATGCAAGAACTTCCCTGGAAGATGAAGAAGTCTTTGAGCAGAAGCACG
TTAAGAAGCCCGAAGGGCTTTTCAGAAATCGGTTTGAAGTTAGAAATGCGGTAAAACTCCTCCAGGCAGCTGACAGCTTTAAAGACCAGA
CCTTCTTTCTCAGCCAGGTTTCCCAGGATGCCCTGAGGAGAACCATCTTCCCTCTGGGGGGATTAACGAAAGAGTTTGTAAAGAAAATCG
CTGCTGAGAATAGACTTCATCATGTGCTTCAGAAGAAAGAGAGCATGGGCATGTGTTTCATCGGGAAGAGGAATTTTGAACATTTCCTTC
TTCAGTATCTGCAGCCTCGACCTGGTCACTTTATTTCCATAGAAGACAATAAGGTTCTGGGAACACATAAAGGTGAACTCCAGAAAGCCA
TTGACTTATTCACAGATGCCATCAAGCTGAATCCTCGCTTGGCCATTTTGTATGCCAAGAGGGCCAGTGTCTTCGTCAAATTACAGAAGC
CAAATGCTGCCATCCGAGACTGTGACAGAGCCATTGAAATAAATCCTGATTCAGCTCAGCCTTACAAGTGGCGGGGGAAAGCACACAGAC
TTCTAGGCCACTGGGAAGAAGCAGCCCATGATCTTGCCCTTGCCTGTAAATTGGATTATGATGAAGATGCTAGTGCAATGCTGAAAGAAG
TTCAACCTAGGGCACAGAAAATTGCAGAACATCGGAGAAAGTATGAGCGAAAACGTGAAGAGCGAGAGATCAAAGAAAGAATAGAACGAG
TTAAGAAGGCTCGAGAAGAGCATGAGAGAGCCCAGAGGGAGGAAGAAGCCAGACGACAGTCAGGAGCTCAGTATGGCTCTTTTCCAGGTG
GCTTTCCTGGGGGAATGCCTGGTAATTTTCCCGGAGGAATGCCTGGAATGGGAGGGGGCATGCCTGGAATGGCTGGAATGCCTGGACTCA
ATGAAATTCTTAGTGATCCAGAGGTTCTTGCAGCCATGCAGGATCCAGAAGTTATGGTGGCTTTCCAGGATGTGGCTCAGAACCCAGCAA
ATATGTCAAAATACCAGAGCAACCCAAAGGTTATGAATCTCATCAGTAAATTGTCAGCCAAATTTGGAGGTCAAGCGTAATGTCCTTCTG
ATAAATAAAGCCCTTGCTGAAGGAAAAGCAACCTAGATCACCTTATGGATGTCGCAATAATACAAACCAGTGTACCTCTGACCTTCTCAT
CAAGAGAGCTGGGGTGCTTTGAAGATAATCCCTACCCCTCTCCCCCAAATGCAGCTGAAGCATTTTACAGTGGTTTGCCATTAGGGTATT
CATTCAGATAATGTTTTCCTACTAGGAATTACAAACTTTAAACACTTTTTAAATCTTCAAAATATTTAAAACAAATTTAAAGGGCCTGTT
AATTCTTATATTTTTCTTTACTAATCATTTTGGATTTTTTTCTTTGAATTATTGGCAGGGAATATACTTATGTATGGAAGATTACTGCTC
TGAGTGAAATAAAAGTTATTAGTGCGAGGCAAACATAACTCATTTGAGGATAAAGTTTGTGTTGGATATGTGGTTCCTGATGCATTTTGA
CTTGTCTTTTTAAATGCTTTATCTTTTTCTTTAAAGATTTATTTCAATAAAACTAATTGGGACCACCCGTATTTCAGTAGGACCTGGGTA
GGGATTGGAAGTACTTGGCAGGGCAGCAGCAATCTTGCTGTGTTTGATATAACATGCATCCTTGGGCAGGTTGCCCTTAAATCTTACACT
GTGGTGAAGGGATGTTTTTTTTGTAATGCTGCAGTAGAGTTGGAGTACTTAGTTCTCTTGTTGTCCAGTATATCTAATAAGTGTTTTTCA
TATTATTTCCACGTAAGGGAAATAAGGTAGTACTTTTCTTTTTATATTTCTATGCTTAAAATTCTCTTTCCTAGTCAAAAATTGCCCAAA
TCTGTGTTTGCTTTCTGCTTGCTACATTTGTCTCCCTTACTTTTCTTGAGCTAAAGACAGGCTTTTTCCACCGGCATCATCACTGCTATC
ATCATTAACAGCGTAATTATACAAGCATATTTAATGCTGAGTTTAATTTAATATGTAATACATATGGTAATTGTAGGGTAATACCCACAA
CAACTGTAGTTTCTTACTTGGCCAAGAGAATGCTTATTTAAGTGTTAGACTTCCATTCTGGCAAAATCTTGCCTTATCAGAAGACATTGG
AAAGAGGGATTCCCTTTGGTGTTTGGTCTTCTACTTAGAAAAACCTATTGCAGTTAGTTTATCTTGTAGTATTCATCTTTGTATTCTGAA
GATAAGGTTTGAATTAAATTGATACACACAGAGGGGAACCGATTTTTTTTATCCAATGTGAATTATAAATGAGATAATCCACAGTTATTC
ATTGTGGAGTTGTTGAGACTATGAAAGACTCATTGTCTTTGTATTCAGCTCTTAAATAGTGTAACTATATCCCCACCTCTGCTTGCTTTC
TTTCCCTCCCCTCCAATGATAAAGAAAATGATAAATTTTCTGTTGTGCATTCAATTCTTATTTTAAATAAGACTAAGTATAGGCATTGTA
CCTGACATTGCTACGTTTCTACCAGTGTTTCAATTTAAAGTGCTAGTGTTTAAAAACATTTTCAAGGGATAAGGCCTTCTGTACTTTGCT
TATTTGAAGAATCAGTGGTAGGAGCAGTGAAGTAAATTCTATGGAGTACATTTCTAAAATACCACATTTCTGAAATCATAAATAAGTTTA
TTCAGGTTCTAACCCTTTGCTGTACACAAGCAGACAGAAATGCATCTGTTACATAAATGAGAAAAAGCTATTATGCTGATGGAGCATGCT
TTTTAAATCCTTTAAAAACACTCACCATATAAACTTGCATTTGAGCTTGTGTGTTCTTTTGTTAATGTGTAGAGTTCTCCTTTCTCGAAA
TTGCCAGTGTGTACTTGGCTTAACTCAAGAACAGTTTCTTCTGGATTCCTTATTTGATTTATTTAACCTAATTATATTCTAATATTGCAA
ATATTACCATAAGTGGGTAAAAGTAAAATTCCTCTTCTGAAAATGTGTCCTGTGCTTTTAGATTTTTAAATTCCATAATATACATTCTTA

>94319_94319_5_TRMU-ST13_TRMU_chr22_46748227_ENST00000381019_ST13_chr22_41231891_ENST00000216218_length(amino acids)=504AA_BP=262
MGDWRMQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDF
LNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNAVKLLQAADSFKDQTF
FLSQVSQDALRRTIFPLGGLTKEFVKKIAAENRLHHVLQKKESMGMCFIGKRNFEHFLLQYLQPRPGHFISIEDNKVLGTHKGELQKAID
LFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKEVQ
PRAQKIAEHRRKYERKREEREIKERIERVKKAREEHERAQREEEARRQSGAQYGSFPGGFPGGMPGNFPGGMPGMGGGMPGMAGMPGLNE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRMU-ST13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneTRMUchr22:46742441chr22:41231891ENST00000290846+41196_98159.33333333333334422.0target base in tRNA
HgeneTRMUchr22:46742441chr22:41231891ENST00000381019+41096_98159.33333333333334377.0target base in tRNA
HgeneTRMUchr22:46748227chr22:41231891ENST00000290846+71196_98257.3333333333333422.0target base in tRNA
HgeneTRMUchr22:46748227chr22:41231891ENST00000381019+71096_98257.3333333333333377.0target base in tRNA
HgeneTRMUchr22:46748227chr22:41231891ENST00000290846+711171_173257.3333333333333422.0tRNA
HgeneTRMUchr22:46748227chr22:41231891ENST00000381019+710171_173257.3333333333333377.0tRNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRMUchr22:46742441chr22:41231891ENST00000290846+411171_173159.33333333333334422.0tRNA
HgeneTRMUchr22:46742441chr22:41231891ENST00000290846+411334_335159.33333333333334422.0tRNA
HgeneTRMUchr22:46742441chr22:41231891ENST00000381019+410171_173159.33333333333334377.0tRNA
HgeneTRMUchr22:46742441chr22:41231891ENST00000381019+410334_335159.33333333333334377.0tRNA
HgeneTRMUchr22:46748227chr22:41231891ENST00000290846+711334_335257.3333333333333422.0tRNA
HgeneTRMUchr22:46748227chr22:41231891ENST00000381019+710334_335257.3333333333333377.0tRNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRMU-ST13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRMU-ST13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource