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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRPC4AP-DYNLRB1 (FusionGDB2 ID:94344)

Fusion Gene Summary for TRPC4AP-DYNLRB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRPC4AP-DYNLRB1
Fusion gene ID: 94344
HgeneTgene
Gene symbol

TRPC4AP

DYNLRB1

Gene ID

26133

83658

Gene nametransient receptor potential cation channel subfamily C member 4 associated proteindynein light chain roadblock-type 1
SynonymsC20orf188|PPP1R158|TRRP4AP|TRUSSBITH|BLP|DNCL2A|DNLC2A|ROBLD1
Cytomap

20q11.22

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionshort transient receptor potential channel 4-associated proteinTNF-receptor ubiquitous scaffolding/signaling proteinTRP4-associated proteinprotein phosphatase 1, regulatory subunit 158trpc4-associated proteintumor necrosis factor receptor-associated dynein light chain roadblock-type 1ROBL/LC7-like 1bithoraxoid-like proteindynein, cytoplasmic, light polypeptide 2Adynein-associated protein Km23roadblock domain-containing protein 1
Modification date2020031320200320
UniProtAcc.

Q9NP97

Ensembl transtripts involved in fusion geneENST00000252015, ENST00000432634, 
ENST00000451813, ENST00000539834, 
ENST00000480759, ENST00000300469, 
ENST00000374846, ENST00000417166, 
ENST00000357156, 
Fusion gene scores* DoF score30 X 25 X 10=750017 X 12 X 12=2448
# samples 3323
** MAII scorelog2(33/7500*10)=-4.50635266602479
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2448*10)=-3.41189779174828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRPC4AP [Title/Abstract] AND DYNLRB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRPC4AP(33622926)-DYNLRB1(33128385), # samples:3
Anticipated loss of major functional domain due to fusion event.TRPC4AP-DYNLRB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TRPC4AP-DYNLRB1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRPC4AP

GO:0006511

ubiquitin-dependent protein catabolic process

20551172

HgeneTRPC4AP

GO:0016567

protein ubiquitination

20551172


check buttonFusion gene breakpoints across TRPC4AP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DYNLRB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A1HN-01ATRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
ChimerDB4COADTCGA-A6-6782-01ATRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
ChimerDB4COADTCGA-A6-6782TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+


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Fusion Gene ORF analysis for TRPC4AP-DYNLRB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000252015ENST00000480759TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-3UTRENST00000252015ENST00000480759TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-3UTRENST00000432634ENST00000480759TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-3UTRENST00000432634ENST00000480759TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-3UTRENST00000451813ENST00000480759TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-3UTRENST00000451813ENST00000480759TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-3UTRENST00000539834ENST00000480759TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-3UTRENST00000539834ENST00000480759TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000252015ENST00000300469TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000252015ENST00000300469TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000252015ENST00000374846TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000252015ENST00000374846TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000252015ENST00000417166TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000252015ENST00000417166TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000432634ENST00000300469TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000432634ENST00000300469TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000432634ENST00000374846TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000432634ENST00000374846TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000432634ENST00000417166TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000432634ENST00000417166TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000451813ENST00000300469TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000451813ENST00000300469TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000451813ENST00000374846TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000451813ENST00000374846TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000451813ENST00000417166TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000451813ENST00000417166TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000539834ENST00000300469TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000539834ENST00000300469TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000539834ENST00000374846TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000539834ENST00000374846TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
5CDS-intronENST00000539834ENST00000417166TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
5CDS-intronENST00000539834ENST00000417166TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
Frame-shiftENST00000252015ENST00000357156TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
Frame-shiftENST00000252015ENST00000357156TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
Frame-shiftENST00000432634ENST00000357156TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
Frame-shiftENST00000432634ENST00000357156TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
Frame-shiftENST00000451813ENST00000357156TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
Frame-shiftENST00000451813ENST00000357156TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+
Frame-shiftENST00000539834ENST00000357156TRPC4APchr20

33622926

-DYNLRB1chr20

33128385

+
Frame-shiftENST00000539834ENST00000357156TRPC4APchr20

33622925

-DYNLRB1chr20

33128384

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TRPC4AP-DYNLRB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRPC4APchr2033622925-DYNLRB1chr2033128384+2.50E-070.99999976
TRPC4APchr2033622925-DYNLRB1chr2033128384+2.50E-070.99999976
TRPC4APchr2033622925-DYNLRB1chr2033128384+2.50E-070.99999976
TRPC4APchr2033622925-DYNLRB1chr2033128384+2.50E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TRPC4AP-DYNLRB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:33622926/:33128385)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DYNLRB1

Q9NP97

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TRPC4AP-DYNLRB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TRPC4AP-DYNLRB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRPC4AP-DYNLRB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRPC4AP-DYNLRB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource