FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TRPC4AP-KCNB1 (FusionGDB2 ID:94346)

Fusion Gene Summary for TRPC4AP-KCNB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRPC4AP-KCNB1
Fusion gene ID: 94346
HgeneTgene
Gene symbol

TRPC4AP

KCNB1

Gene ID

26133

3745

Gene nametransient receptor potential cation channel subfamily C member 4 associated proteinpotassium voltage-gated channel subfamily B member 1
SynonymsC20orf188|PPP1R158|TRRP4AP|TRUSSDRK1|Kv2.1
Cytomap

20q11.22

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionshort transient receptor potential channel 4-associated proteinTNF-receptor ubiquitous scaffolding/signaling proteinTRP4-associated proteinprotein phosphatase 1, regulatory subunit 158trpc4-associated proteintumor necrosis factor receptor-associated potassium voltage-gated channel subfamily B member 1delayed rectifier potassium channel 1potassium voltage-gated channel, Shab-related subfamily, member 1voltage-gated potassium channel subunit Kv2.1
Modification date2020031320200329
UniProtAcc.

Q14721

Ensembl transtripts involved in fusion geneENST00000252015, ENST00000451813, 
ENST00000432634, ENST00000539834, 
ENST00000371741, 
Fusion gene scores* DoF score30 X 25 X 10=75007 X 4 X 6=168
# samples 337
** MAII scorelog2(33/7500*10)=-4.50635266602479
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRPC4AP [Title/Abstract] AND KCNB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRPC4AP(33657099)-KCNB1(47991529), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRPC4AP

GO:0006511

ubiquitin-dependent protein catabolic process

20551172

HgeneTRPC4AP

GO:0016567

protein ubiquitination

20551172

TgeneKCNB1

GO:0001508

action potential

19223394

TgeneKCNB1

GO:0071805

potassium ion transmembrane transport

19074135|19223394

TgeneKCNB1

GO:0090314

positive regulation of protein targeting to membrane

19074135


check buttonFusion gene breakpoints across TRPC4AP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A84H-01ATRPC4APchr20

33657099

-KCNB1chr20

47991529

-
ChimerDB4LGGTCGA-TM-A84HTRPC4APchr20

33657099

-KCNB1chr20

47991529

-


Top

Fusion Gene ORF analysis for TRPC4AP-KCNB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000252015ENST00000371741TRPC4APchr20

33657099

-KCNB1chr20

47991529

-
In-frameENST00000451813ENST00000371741TRPC4APchr20

33657099

-KCNB1chr20

47991529

-
intron-3CDSENST00000432634ENST00000371741TRPC4APchr20

33657099

-KCNB1chr20

47991529

-
intron-3CDSENST00000539834ENST00000371741TRPC4APchr20

33657099

-KCNB1chr20

47991529

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000451813TRPC4APchr2033657099-ENST00000371741KCNB1chr2047991529-1155644052449814
ENST00000252015TRPC4APchr2033657099-ENST00000371741KCNB1chr2047991529-11620504692513814

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000451813ENST00000371741TRPC4APchr2033657099-KCNB1chr2047991529-0.0008132260.9991868
ENST00000252015ENST00000371741TRPC4APchr2033657099-KCNB1chr2047991529-0.0008282880.99917173

Top

Fusion Genomic Features for TRPC4AP-KCNB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TRPC4AP-KCNB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:33657099/chr20:47991529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KCNB1

Q14721

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:8081723, PubMed:1283219, PubMed:10484328, PubMed:12560340, PubMed:19074135, PubMed:19717558, PubMed:24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:23161216, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:8081723}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102517_520189859.0Compositional biasNote=Poly-Ser
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102701_706189859.0Compositional biasNote=Poly-Ala
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102365_376189859.0IntramembraneHelical%3B Name%3DPore helix
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102377_384189859.0IntramembraneOntology_term=ECO:0000250
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102377_382189859.0MotifSelectivity filter
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102448_481189859.0RegionSelf-association
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102209_228189859.0Topological domainExtracellular
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102251_259189859.0Topological domainCytoplasmic
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102281_294189859.0Topological domainExtracellular
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102317_330189859.0Topological domainCytoplasmic
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102352_364189859.0Topological domainExtracellular
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102385_391189859.0Topological domainExtracellular
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102421_858189859.0Topological domainCytoplasmic
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102187_208189859.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102229_250189859.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102260_280189859.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102295_316189859.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102331_351189859.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNB1chr20:33657099chr20:47991529ENST0000037174102392_420189859.0TransmembraneHelical%3B Name%3DSegment S6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNB1chr20:33657099chr20:47991529ENST000003717410259_75189859.0RegionSelf-association
TgeneKCNB1chr20:33657099chr20:47991529ENST00000371741021_186189859.0Topological domainCytoplasmic


Top

Fusion Gene Sequence for TRPC4AP-KCNB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94346_94346_1_TRPC4AP-KCNB1_TRPC4AP_chr20_33657099_ENST00000252015_KCNB1_chr20_47991529_ENST00000371741_length(transcript)=11620nt_BP=504nt
ACTGGGGGCGCTGCGGCGACCCCTCCGCCGCCCCGTAGAAATCTCCGCGGCCCCGAGGCCGCTTGCTTCCTGTTTGTCCGACGAGGAGAC
ATGGCGGCGGCGCCGGTAGCGGCTGGGTCTGGAGCCGGCCGAGGGAGACGGTCGGCAGCCACAGTGGCGGCTTGGGGCGGATGGGGCGGC
CGGCCGCGGCCTGGTAACATTCTGCTGCAGCTGCGGCAGGGCCAGCTGACCGGCCGGGGCCTGGTCCGGGCGGTGCAGTTCACTGAGACT
TTTTTGACGGAGAGGGACAAACAATCCAAGTGGAGTGGAATTCCTCAGCTGCTCCTCAAGCTGCACACCACCAGCCACCTCCACAGTGAC
TTTGTTGAGTGTCAAAACATCCTCAAGGAAATTTCTCCTCTTCTCTCCATGGAGGCTATGGCATTTGTTACTGAAGAGAGGAAACTTACC
CAAGAAACCACTTATCCAAATACTTACATTTTTGACTTGTTTGGAGGTGTTGATATCCTTGCCATAATTTCCATCATGTTCATCGTCCTC
TCCACCATTGCCCTGTCCCTCAACACGCTGCCTGAGCTACAGAGCCTCGATGAGTTCGGCCAGTCCACAGACAACCCCCAGCTGGCCCAC
GTGGAGGCCGTGTGCATCGCATGGTTCACCATGGAGTACCTGCTGAGGTTCCTCTCCTCGCCCAAGAAGTGGAAGTTCTTCAAGGGCCCA
CTCAATGCCATTGACTTGTTGGCCATTCTGCCATACTATGTCACCATTTTCCTCACCGAATCCAACAAGAGCGTGCTGCAATTCCAGAAT
GTCCGCCGCGTGGTCCAGATCTTCCGCATCATGCGAATTCTCCGCATCCTTAAGCTTGCACGCCACTCCACTGGCCTCCAGTCTCTGGGC
TTCACTTTGCGGAGGAGCTACAATGAGTTGGGCTTGCTCATCCTCTTCCTTGCCATGGGCATTATGATCTTCTCCAGCCTTGTCTTCTTT
GCTGAGAAGGATGAGGACGACACCAAGTTCAAAAGCATCCCAGCCTCTTTCTGGTGGGCCACCATCACCATGACTACTGTTGGGTATGGA
GACATCTACCCCAAGACTCTCCTGGGGAAAATTGTTGGGGGACTCTGCTGCATTGCAGGAGTCCTGGTGATTGCTCTTCCCATCCCCATC
ATCGTCAATAACTTCTCTGAGTTCTATAAGGAGCAGAAGAGACAGGAGAAAGCAATCAAACGGCGAGAGGCTCTGGAGAGAGCCAAGAGG
AATGGCAGCATCGTATCCATGAACATGAAGGATGCTTTTGCCCGGAGCATTGAGATGATGGACATTGTGGTTGAGAAAAATGGGGAGAAT
ATGGGTAAGAAAGACAAAGTACAAGATAACCACTTGTCTCCTAACAAATGGAAATGGACAAAGAGGACACTGTCTGAAACCAGCTCAAGT
AAGTCCTTTGAAACCAAGGAACAGGGATCCCCTGAAAAAGCCAGATCGTCTTCTAGTCCTCAGCACCTGAACGTTCAGCAGTTGGAAGAC
ATGTACAATAAGATGGCCAAGACCCAATCCCAACCCATCCTCAATACCAAGGAGTCAGCAGCACAGAGCAAACCAAAGGAAGAACTTGAA
ATGGAGAGTATCCCCAGCCCCGTAGCCCCTCTGCCCACTCGCACAGAAGGGGTCATTGACATGCGAAGTATGTCAAGCATTGATAGTTTC
ATTAGCTGTGCCACAGACTTCCCTGAGGCCACCAGATTCTCCCACAGCCCTTTGACATCACTCCCCAGCAAGACTGGGGGCAGCACAGCC
CCAGAAGTGGGCTGGCGGGGAGCTCTGGGTGCCAGTGGTGGTAGGTTTGTGGAGGCCAACCCCAGCCCTGATGCCAGCCAGCACTCTAGT
TTCTTCATCGAGAGCCCCAAGAGTTCCATGAAAACTAACAACCCTTTGAAGCTCCGAGCACTTAAAGTCAACTTCATGGAGGGTGACCCC
AGTCCACTCCTCCCCGTTCTAGGGATGTACCATGACCCTCTCAGGAACCGGGGGAGTGCTGCGGCTGCTGTCGCTGGACTGGAGTGTGCC
ACGCTTTTGGACAAGGCTGTGCTGAGCCCAGAGTCCTCCATCTACACCACAGCAAGTGCTAAGACACCCCCCCGGTCTCCTGAGAAACAC
ACAGCAATAGCGTTCAACTTTGAGGCGGGTGTCCACCAGTACATTGACGCAGACACAGATGATGAGGGACAGCTGCTCTACAGTGTGGAC
TCCAGCCCCCCCAAAAGCCTCCCTGGGAGCACCAGTCCGAAGTTCAGCACGGGGACAAGATCGGAGAAAAACCACTTTGAAAGCTCCCCT
TTACCCACCTCCCCTAAGTTCTTAAGGCAGAACTGTATTTACTCCACAGAAGCATTGACTGGAAAAGGCCCCAGTGGTCAGGAAAAGTGC
AAACTTGAGAACCACATCTCCCCTGACGTCCGTGTGTTGCCAGGGGGAGGAGCCCATGGAAGCACACGAGATCAGAGCATCTGAACTGCC
CTGCCTTGGAGGAGAGACTTTTGGGTGAGGTCCAAAGAGGAGAGCTGTTCAGCTTACCTGCCACAGAGCTTTTCTGCATGAACTCTGGAA
CAGAAAGGCCCTGTAAAGCCCTCAGAGAGAAGAGAGACTCCAGAGAAGGCTCCCTAAGACCTTGAGAGCCATGACAGGTCCATCAGCATG
AAGTTGGCCAAGCCATAGGGCACAGCACCTCCTTGTAACAACTCTATAGCCCTCTTTGGGAGATGACATGAGTGGAACTCACAGCCACCA
CTACCACCACTTTAGACAGGACCGAGGCCACATACTCCCCATTCTCTCGTGGCTTTCCATCTCAGCCTCGGAGGGCAACATTGACAGTCC
TCCTGGCTTCAGCTAGAGAAGGATGCTGGAACAAGCGGCTGGTGTTGAAAGAGTGGGTTGACCAATTTGGTATTGAATGTTGCCCAGCCA
CCCCTAGGAACACCTGTCCATCACCTCCTGGATGGATTCCACTGTTAGACAGCTACAGGGAATGATTGGTCATGGGGAAGTCTCTGCGCC
ATAAGCCACGATCCCAGCGCAAAACCCTTACTCAAATGTCTTCATTGACTTCGGTATTTCATAGTACCTGAGATTTTATTTTGAGATACC
ATCAGGGTGAGTTGCACCACTTGTACTCAATTCTAATTGCCCCCTGGCAATCTGGGAAGGGTTCAGAAGGTGGGCACCCAGCCAACAGCA
TGAACTCAGAGCATTGTTTTAGGGTTGGAGGAGGAACACGCTTTCTTTACATCACTAGTGTAGACTCAAAAGATATGCAAGTGTCAAATA
TGCAAAAGAAATAGTTTATTCAAAGAGACTGTGTGTTACTGAAGAACAGCATAAAAATATGATTTTTTTACTTGCAAAAATGAAAGGAAA
AAAATACCACGCATTGAAATGCCCAGTTCAGACTGAATAATTCCTGCTGCAGCAAGGAAAGTACCTACTATAATAGAAATTCTGTTTTGT
TTTCTGTGGTTTTCAAGTTAAAAAAAAAAAAGTTAAAATAAAAAGCACTTTATGTTTTTCAAAAATAGGTTCTGCCAGGGACAGTGTCAA
CATCTTGCACTTTAAAATAAGCACTATTTCCCATAGCCCAATTGTTGGGACTGTAGTTGGATTGTTGCTACCTGCCCATTTCTGGCCAGC
ATGGGTAATATTGTGCTGGTATTACTGTCTGCCATATCAAAGTCTGTGGGCTCCTTCCCTGCCCCTCTGAAACCTTCCCTTAACCCTCAT
GGGTCAGGAGGGGTTCTTGCCCCTTGGGTGGGGCCTCTCATGAAGTCAAGTATACAGGAGACATGCACATCTCAAAAGGACACAGTGACA
GTTGGACATTGGGTGTTTTACTCTGTTCTCTTTCTTGTCAACCAGCTATTGGTTTTTCAGTGTCACTGTCTGTACTAAAAGCTCAACTCT
CCTTCCTGCAGCCATCGATGCAGCCAGTACAGACAAAAGCAATAAGTATTTGTGTGCATCCTGAGTGGTTCTGGTGTATTTCTTGGTGTT
GGTTTTCCTGTCCTCGTTTGATGACCTGGCATTGTCCTGCCTGCTTTTAGTCCAACAGCATGGTGTTGTTGGCCATTCCTCAGTACAGTG
GCATTAGGTTGAACCACTGATGAATACAATGCTATAGTGTTGGCTCACCTGTCAGTAAAGATGACATGTTATTGGTCTGCCTGTCTGTAG
TACAATGGAACAATGTTGTTCTCTTAATGTAATGTTGATGGATGATGTCCCAAGTACAATAGTGTAGTTCTGTCTATCCTCAATACAGTA
ACAGGCATATGTCTTCCCAGTGGAAGAAAGATATGGTATTGGTTCACCTAGTCTTAAGTCTCAATATCATCTGTTGCTGGTCTGCCTGTT
AGTACAATGGCATGATCCACCTCTCAGTACACAAATATCATGGAGCTGTTCTGCCTGCTCTTCATACATAAGGCATAAGGTTGAGCCACC
TGCCACACATATGATGAGATGGGATCATTCCACCACCCTTAAAAATATGTCTTCTCTGCTGTATACAAACCCAATTCATAACACTTCTCA
GCATCTCCAGAGACTGTAGATCCCCCCAAGAGGGTGCAGTCCTGTTCTTTGCCGCATTAACAGAGAAAACGAGAACGTCACTCTTCCTAG
GTATCTTCAGAGTATTCGCGCAGCAACTGCAAAGGGACTTAGGGGCAGGGAGAGTGTGAGGTCATCCCGTGCCAGGCAGAGGAAGCAGCA
CTCCCAAAACACTTTGCTGAACACGCAGTCTGAGCTGGGGGCCTCTTGAGGAATGACTGTGGGACAGTTCTCCGCCGACCATCTCACATG
TCTCTTCTTTGTTTTCATCACCATTAATGTCCACCATCAGCACAAATGTGAAAATTCAGGGAAAAAAACAAATGCTTTTTGATAAAAGTA
AATAGTTGTGATTTCCAATTCAGATATTTTTAGAGCTGATGCTATCTGTAAAAAATAATAATAATAATAATATAGTCTATTTTACATATC
AGGAAAGTGAACATGTTTCAATATAGCCATATATATTGAGAAGGAACTTACCACCCCTTCTTCCAATCGAGGCATTTCATTTGTTGGTTG
AAGCAGATGAGAACTGTACAGATTGAAAATGATTTGTTTTTTTTTTTTTTTAAAAAAAACGAAAACCAATTGGTGCAACTCTCCTTGTAA
CCAAAGGCCCTTTCTGCCTTCTGTGGTCATGTAGGACCTGGCCCTTCCTTCCTTGTGTATTTTGTCCAACCGTAAAGTAGCATTTTATTG
AGTCACTTTTGAAGGACGAATTCAGAAGTATCATTAAGAACCTACCTTTTCAGGCTTCATAGCCAGAGTCCTATAGAGTTCTTATAGAAA
CAGAATAATTGAAATTCAGCATATACTATGCTTAGAAAGTATTTTGTTTGGGTTTGATTGGGTTTTTTTTTCTTTTACTTGTGTGTGTAT
GTACTGGGGGAGTATAGCTTTTATTCTGTGCTCAATTCGAAAGAGAGTATTATAAGTTTTCCCAGCCCATCCACCCGCTAAAAAAGAACA
TATCCAAATTTTAATATGTATACACCCAACCTGTACCTATGTACGTGAATATACATGCACTGGGAAATCTACTTAAGAGTCTTCACTGAG
AAGTTCACTCGATAGAAAGGTCTTGATAGAGAAGAGAAGAGGAAAGCAATGGTCTGAAGGCAAATCCTGCTTTAACTTGGTGGTCCATTT
CCCATTCATTCCTGAACCAATGAGAGCAGAAAGAAACAAGTCAACCCAAACAAGCAAACTAGGGGCTGGACGCGGCGAATGGATGCTGGT
CAGTTTGGCAAATTCACTGAAACTCATCAAGAACCCAGCTGAACTTGCATTCCAACTTCCACAATTATCTGAAAGGGCTAGGGACCAGGT
AGCCATGTGTCCCAATCACACGGGGGAGAGTCTGCCACCGGCGGTGAGAGAGGTGGGGAAGCTTTGGAGGAGACAGTATATTCACCTTTT
TATCTTTGGGTAAAAGAAACCAACAGGACTTTGGTGCAGTAGATTTCTCAGTGCCTTCTTTAGGAATTCTATCTTAAGCACACTTCAAGG
GGAAAGAAAAAAGGAGGAGAGAACATTTGTTCCCGTGAAGTCCCTTTCTCCAAAGGACTGGGGATCAAGAAGGAAGAAGAGTAAGAAGGA
AAAACAACAAAATCCTGAGGAGGCCATTTCTTTTAACCCACCCAGCTTGCCCCTGAAAACTGCTGGTGATACAAACTTTTTCAAACTGAC
TTCCAGCTTCTCCATGTGTCTTGGTAACTGTAGCCTCGTCTCTGCCCTTTCTCCTAATAAGATCCATGTTTCTAAGGAGAAAAACAAAAC
AGTATTCTCTTCTGTAAAACTGTAATGTATTGTTGATATTTGTAACTATTGTATATTTCTGTCTTGCTCCAGTCCCAGCTGGAGTGTCTA
GTTCCATGGACAAGGGGATATTTAAAATTCACCACGGACAAGAGCCACTAAAGCCAGGTCTCTATCGCTAATCTCTCTCCTATTCTTATT
TCTCTACCAACTAATCTCAAGTAACAATACCCCAGGCTTTTTTTCAGCCTCAATTCAAGTAACTTTGAATCAAAAGAGAGCAAGGCAAAA
AGCCTCCGGACATGCTTCTTTGGGAAAGGACTTTTTCTGTAGCTGCAGAGTGGGCAGGAGGGAGAAGGGGCTCCCCTGAGACCCCGGCAG
GACAATGGAAAGCTTCCAGCCCCGAGCTGATGTTTCCTCACCTATCACTGCTTATAGGACAGCATCCAAATGCTTTCATGTCACTCAGCC
CAGGCAACCCAAACCAGTCCTGGCTACACCCAGAAATAAGAGTTACCTCTGCATTTTCTGTTGCCATTTTTCTGGCTCTAGAAGTATCTG
ATGCGCGACTATGTCATAGAATGTCCACGCATCTCAGAGTAGTCTATTTTTCTGTTCAGATAAAATATATATATATATGTATTTTTAGCA
AATTTATAATAGGGCAATTGAGTCTAATTTCTTCTTTTGTAATACAGAACAATATCTTAGGAGTTTCATTGTTGGTCATTATCGTAGCTG
ATGTTTTCTGGTCTTTTGCAGTTCCTACCATTGTCCCTTGGGCTGTTTGGGTTTTCTTCCTTTTGATTCTGATTTCTTGAGGGTGGGGAA
AGACTTTGGGGTTTGACTTCCTTGTGTAGGCATTTCTTGACACTAGGCCTGGACTCTGTCAATGCTGTGACTTTCCTCATTCATTTCTGT
GTGTTTCTCCCATTCGTTGTTCTTAAGAATCCAGGGCATGAATGCAGGAATGAGACCCAGGGAAGCAGAGCTACAGATGGCCCTCAAAAT
CAGGATGGGATGTGGGCTGGTTTCACTTATATCCCACACCCCTTTAGGGATCTGAAGGGACTGAGTTTTCTCATCCCCAGAGATCTTGGA
ACCAAAAATCTCATGCAAGCAAACTCATCACTGGCATTTCTGAGATCCAGAACACATGTGAGTCCCTCCTGGCTGGGCTGCTCCCACATG
TCCAGCACCCTGTCGGCCTGTAACATCAATCAGAGCTGAAGGTCAGAGGTTTTTCAGGTTCTCGTGAACCTCACAAGAACATGCTGGGCC
TCCGATCTCACCAACTTGTTTATCAGTTCCTTGTTTCGATCTGTTTATTTATTTATTTTTTTGTTATTATTATTTTGAGACAAAGTCTTG
CTCTGTTGCCCAGGCTGCAGTGCAATGGCGCAATCTCGGCTCACTGCAACCTCCTCCACCCAGGTTCAAGTGATTCTCATGTCTCAGCCT
CCTGAGTAACTGGGATTACAAGAGCGCACCATCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGGCAGAGTTTCTCCATGTTGGCCAGG
CTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAGTGCTAGGATTACAGGTGTGAGCCACCACTGCACCCAGTCC
ATTTCAATCCATTTCTAACAGCTTCACCAAAAAACAGTGGCCAGACACCCTTGCAGCCAAACCCTGAGAAGAGATGTCCCCGAATCTGCT
AGCTCATCTCCCCTTCCCTTGCCAGCTGCCTGGCTCCATAGAGCAGGAGGTGTGTGGCAAGGACAGGGGCAGTTTTCCAGCTTCCACCTA
TCCACGCCTGGGGGAGTTTTTGGACTGTCCTGATAATTAATTCCAGAGGCAGTTTTCAGTCCTGGGTGGGCGGAGGACATCTCACTAGGC
AGGATCTTCAGCAGAAAGTGATTCTCCATCCGTCAACTCATGCAGGAAGATGAAGAAAGCCCAGATAATCTCCAACTTGCATTCGTTTAG
GTTTTGGTATACCACCCACCTCACTGTCAGCTGCAGGGCTTGGGGCTCTGCCTAGAATCAGAAATTTGAGCCAAACTGGGACCCTCAGAT
GGCAGTGAGCCATCCCATCAGATAACTCCCAAGAGGAAGCCAACTCAAATATGAATTTTATTATTCTGGACTATGACCCTGATCAGAGTT
CTCCCACCCCGAAAACCTCTGATAGTCTGGTTTGAACCAGAGTCAAATAAAACAGACAAGATTTTTTTTTCCTCTGCACAAAAGCAAAAA
AACAAAACAAAAAAAAGTCTGCCAGTAGTTTCCTGGGTTTGATGCCCAGATAAGCAAACACTGTTGCCTATGGCTGTTGCTGTTTTCATC
AAGAAAGAGGTTATATAGTTTGCATTTCCATCCACTCTCCCTGATTTTATCTTAACCTAGAATTTCTCCTGAACTACCCCAAATGCCAAC
TTGAATTTGGGTAGGGCTCTGTTAATCGAGGGAACCCTCATCTTCACTTATAAACCTAATTCTCTGTTCCTCCCTCCAAAGATCCTGAAA
AGATCTCCTAAAGGCTGGCCAGGATGGGGTGGAGTGGGGCAGTGCACCTGAAGAAAAAAACTTAGCTGCCAGCTGGCTGTATGCAAGTTC
TCCGAAAATTTCTATTGTATGAAAGGGATGGGGTCAATTGCAGCTCAAATTAAGGAAGCCCTCCTAACAGGCTGGGTTGTCTGACCATGG
AGCTCAATGCCATGGTGGACAGTGAGCTCCCTTATATCACAGGTGTTTAAAGAGAGGCTGGCTAGATGGTGTAAAAAATGGGCATTGCAG
AGGGGCCCTAGCATTGCATGGAAACTGGGCTGAACAACCACAGAAATTCCTCTTTGTTTCTTGGAGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTAGGTGGTTTCAACACTCTGGATATAAGCTCAAGCCACTGAGGCAAAGGCATGCAGCACAATTAGCAGGAAT
GCAACTTCTGGGCTTTGGAGCTCTCAGAGGGGGTGTCCAAGAGACAAGTCTGCTTCCTTCCGGCTCCGTCTTGGAACATTTTAATGACTG
TCAGTCACCAATCCAACCCATCCCCAGTGGCCTACCAGGCACCACATTGGGATGAGACTCATGCTACCCTTCCCCAGGCCAGCCAAGGAG
CAATCCACGCTGTCCCCCATCCCTGGCTGGCTGTCTTATGGTGCTTCAGCCCCTCCGCCCAGCTCCTGTGCCCTCATGAGCCTGGGGCTT
TCTGTATAAAAGATGCAATGATATCTGTTCCCCACTAGCCATCCCCACAATGAACAACTTCCCAGGCAATAGCAAATGGCTCCATTCCAA
AAGGGCTTGTTTTTTTGGTAAATCAAATAAGAGACCCCACTCAAGACCTTTGAAAGTCCCCGTCAATGAAAAAAATCCAGAAGGGTCAAA
AGAGAAAGGCAGCTTTTAATCCAGTTTCACAGCAAAACCAGGCTCTTGGCTGCCTCCAAGCAGAATGCCACTCTCCTGCAGCTGTGGCCT
CCATCCCAAATCATCCTGCATACTGCATTCTCTAAGGAAAGCATTTGACAAGAGAGGGTTTATGTATGGTGGATTGGGAGAAAGTGAGAC
TTCAACCTCAGGGTGAACCGAAGACTGGTTTGTCTTTGGTTGTTTTAGTATGAGGTTGGGCAGGATGATATGTTTGGATGGGTAGAATGA
GCAGCCGCCTTCCTCTGAAACCAAAATAAAATAAAAACCAGTTTTCAAGATTCCTCCCAACTCCTCACTGGAGGCTCTGCCCTGCAGAAT
CACTCAAGTTGCAACAACACAAGGAGACAAAAATAGGATATTTCATGAAAATATAAGAAACTCCCAATTCCGTCCCATTAGGATGCCCTC
AAGGGGCCATGCAGGGATCTTCCCATACTTCCTGCTTCCCTGATCTGAACCAAGATTGGAAAGAGGCAGGCAGCAGAGAAGATGCCCAAG
AAACTCTGACATATCCACAGCTTGGCTCTGCCCCTTGGGCTTCACTGGGGTTTGGGCCTCCCTCTTGGTTGAGCTGAGTGTGCCTGAGTG
GGTGGGGACAGGGAGGATTCTCCAGGTCTATCTTGATTTCATAGGTCCTTCTCAATCCAAGGTCAAAAACTGAGAATCTTATTTTCTGCA
CCAGGAACTCAGGGTTATCCCCAACCTATGCCGCTGGCACATGATGGTCATCCAACCTGTGTTTTTGTGAGTGAGTGAATGTGTGACTGG
TTGGCCTCTGAGTGGATGACTGGATGCGTGAATGTGTGAGTGAATGGGGGAGTTAATGAATCCCTACCTAACTGTGAAGAGAAGAAAAAT
GAGGAGCCCCTCTCCCACTGAAACCCATAACTGCCCCATCAAGGTCATCTTTCTTTGACTCAAGATGACATCTCAATTTGATGCTTGTAG
GCCCCAAGCTGATAAGGGCCACAGCCCTCTCAGAGCCACACTTCCTGGGGGCCCACAGAGCAGCTCTGCCCTCCTTCCTCTTCCCCTACC
CTGCATTTCTCAGCCTCATGTTCTATTTTAGCTCACACACGACCCATGGGGGGGACCACCAAGTGGTTTTCCAATGGACTAAGCCAAGGG
TTCGAAGTTGGGACTTCCTTTGGTCTGGGACTTCCTGGGGCAGAAACATAGGAGCCAACATCTGGAAACTGGATTGCATTCCCTGAGCCA
TGGGAGTCCAGCTGGATATTAAGGCCAGCCTGCCCTCCAGCTTTTAGAGCCGAAGATCTTTTTTTCTGAGCCCCAAAGCCGTCATGATAG
TATGCCCCCAGATCCCATCAGCTAAGACCCTGTCTCTCCCAGGAACCCGTCGTGTGAGGTTGGGGCTTTTCTGCCAGTAAAGCCATTCTG
ATCACCTCACCCTTGACAGGGGCCAAGCCAATCACATTAGCCATAAATGACCAATGTCCTCAGCCACTCTTTTCTCGGGGGTGCATTCGT
GGGTCCTATTCATCTCTCGTCAGTTAATGTCTCTAGTCCTTCCTGTAAAGGTGAAAATAAGCATTGCGCATGTGCGCAACACACACGCAC
ACACACACACACACACACACACACAAATCCCAGTGTCTTTTTATGCATGTGGTGAGATGAAATTGTGATCTTTGTGTGACCTCCAGCTGC
TGTCTTGTCTTGTAAAATATGTCCAAATGTTTAAGAATTTCTAAGCAAATGGTCCCTTAATGAAGTCTGCAGAGTTCAATAAAAGGTATG

>94346_94346_1_TRPC4AP-KCNB1_TRPC4AP_chr20_33657099_ENST00000252015_KCNB1_chr20_47991529_ENST00000371741_length(amino acids)=814AA_BP=145
MFVRRGDMAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHT
TSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDILAIISIMFIVLSTIALSLNTLPELQSLDEFGQST
DNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHS
TGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV
IALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKRT
LSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRS
MSSIDSFISCATDFPEATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSSMKTNNPLKLRALKV
NFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEG
QLLYSVDSSPPKSLPGSTSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPDVRVLPGGGAHGSTR

--------------------------------------------------------------
>94346_94346_2_TRPC4AP-KCNB1_TRPC4AP_chr20_33657099_ENST00000451813_KCNB1_chr20_47991529_ENST00000371741_length(transcript)=11556nt_BP=440nt
GCTTCCTGTTTGTCCGACGAGGAGACATGGCGGCGGCGCCGGTAGCGGCTGGGTCTGGAGCCGGCCGAGGGAGACGGTCGGCAGCCACAG
TGGCGGCTTGGGGCGGATGGGGCGGCCGGCCGCGGCCTGGTAACATTCTGCTGCAGCTGCGGCAGGGCCAGCTGACCGGCCGGGGCCTGG
TCCGGGCGGTGCAGTTCACTGAGACTTTTTTGACGGAGAGGGACAAACAATCCAAGTGGAGTGGAATTCCTCAGCTGCTCCTCAAGCTGC
ACACCACCAGCCACCTCCACAGTGACTTTGTTGAGTGTCAAAACATCCTCAAGGAAATTTCTCCTCTTCTCTCCATGGAGGCTATGGCAT
TTGTTACTGAAGAGAGGAAACTTACCCAAGAAACCACTTATCCAAATACTTACATTTTTGACTTGTTTGGAGGTGTTGATATCCTTGCCA
TAATTTCCATCATGTTCATCGTCCTCTCCACCATTGCCCTGTCCCTCAACACGCTGCCTGAGCTACAGAGCCTCGATGAGTTCGGCCAGT
CCACAGACAACCCCCAGCTGGCCCACGTGGAGGCCGTGTGCATCGCATGGTTCACCATGGAGTACCTGCTGAGGTTCCTCTCCTCGCCCA
AGAAGTGGAAGTTCTTCAAGGGCCCACTCAATGCCATTGACTTGTTGGCCATTCTGCCATACTATGTCACCATTTTCCTCACCGAATCCA
ACAAGAGCGTGCTGCAATTCCAGAATGTCCGCCGCGTGGTCCAGATCTTCCGCATCATGCGAATTCTCCGCATCCTTAAGCTTGCACGCC
ACTCCACTGGCCTCCAGTCTCTGGGCTTCACTTTGCGGAGGAGCTACAATGAGTTGGGCTTGCTCATCCTCTTCCTTGCCATGGGCATTA
TGATCTTCTCCAGCCTTGTCTTCTTTGCTGAGAAGGATGAGGACGACACCAAGTTCAAAAGCATCCCAGCCTCTTTCTGGTGGGCCACCA
TCACCATGACTACTGTTGGGTATGGAGACATCTACCCCAAGACTCTCCTGGGGAAAATTGTTGGGGGACTCTGCTGCATTGCAGGAGTCC
TGGTGATTGCTCTTCCCATCCCCATCATCGTCAATAACTTCTCTGAGTTCTATAAGGAGCAGAAGAGACAGGAGAAAGCAATCAAACGGC
GAGAGGCTCTGGAGAGAGCCAAGAGGAATGGCAGCATCGTATCCATGAACATGAAGGATGCTTTTGCCCGGAGCATTGAGATGATGGACA
TTGTGGTTGAGAAAAATGGGGAGAATATGGGTAAGAAAGACAAAGTACAAGATAACCACTTGTCTCCTAACAAATGGAAATGGACAAAGA
GGACACTGTCTGAAACCAGCTCAAGTAAGTCCTTTGAAACCAAGGAACAGGGATCCCCTGAAAAAGCCAGATCGTCTTCTAGTCCTCAGC
ACCTGAACGTTCAGCAGTTGGAAGACATGTACAATAAGATGGCCAAGACCCAATCCCAACCCATCCTCAATACCAAGGAGTCAGCAGCAC
AGAGCAAACCAAAGGAAGAACTTGAAATGGAGAGTATCCCCAGCCCCGTAGCCCCTCTGCCCACTCGCACAGAAGGGGTCATTGACATGC
GAAGTATGTCAAGCATTGATAGTTTCATTAGCTGTGCCACAGACTTCCCTGAGGCCACCAGATTCTCCCACAGCCCTTTGACATCACTCC
CCAGCAAGACTGGGGGCAGCACAGCCCCAGAAGTGGGCTGGCGGGGAGCTCTGGGTGCCAGTGGTGGTAGGTTTGTGGAGGCCAACCCCA
GCCCTGATGCCAGCCAGCACTCTAGTTTCTTCATCGAGAGCCCCAAGAGTTCCATGAAAACTAACAACCCTTTGAAGCTCCGAGCACTTA
AAGTCAACTTCATGGAGGGTGACCCCAGTCCACTCCTCCCCGTTCTAGGGATGTACCATGACCCTCTCAGGAACCGGGGGAGTGCTGCGG
CTGCTGTCGCTGGACTGGAGTGTGCCACGCTTTTGGACAAGGCTGTGCTGAGCCCAGAGTCCTCCATCTACACCACAGCAAGTGCTAAGA
CACCCCCCCGGTCTCCTGAGAAACACACAGCAATAGCGTTCAACTTTGAGGCGGGTGTCCACCAGTACATTGACGCAGACACAGATGATG
AGGGACAGCTGCTCTACAGTGTGGACTCCAGCCCCCCCAAAAGCCTCCCTGGGAGCACCAGTCCGAAGTTCAGCACGGGGACAAGATCGG
AGAAAAACCACTTTGAAAGCTCCCCTTTACCCACCTCCCCTAAGTTCTTAAGGCAGAACTGTATTTACTCCACAGAAGCATTGACTGGAA
AAGGCCCCAGTGGTCAGGAAAAGTGCAAACTTGAGAACCACATCTCCCCTGACGTCCGTGTGTTGCCAGGGGGAGGAGCCCATGGAAGCA
CACGAGATCAGAGCATCTGAACTGCCCTGCCTTGGAGGAGAGACTTTTGGGTGAGGTCCAAAGAGGAGAGCTGTTCAGCTTACCTGCCAC
AGAGCTTTTCTGCATGAACTCTGGAACAGAAAGGCCCTGTAAAGCCCTCAGAGAGAAGAGAGACTCCAGAGAAGGCTCCCTAAGACCTTG
AGAGCCATGACAGGTCCATCAGCATGAAGTTGGCCAAGCCATAGGGCACAGCACCTCCTTGTAACAACTCTATAGCCCTCTTTGGGAGAT
GACATGAGTGGAACTCACAGCCACCACTACCACCACTTTAGACAGGACCGAGGCCACATACTCCCCATTCTCTCGTGGCTTTCCATCTCA
GCCTCGGAGGGCAACATTGACAGTCCTCCTGGCTTCAGCTAGAGAAGGATGCTGGAACAAGCGGCTGGTGTTGAAAGAGTGGGTTGACCA
ATTTGGTATTGAATGTTGCCCAGCCACCCCTAGGAACACCTGTCCATCACCTCCTGGATGGATTCCACTGTTAGACAGCTACAGGGAATG
ATTGGTCATGGGGAAGTCTCTGCGCCATAAGCCACGATCCCAGCGCAAAACCCTTACTCAAATGTCTTCATTGACTTCGGTATTTCATAG
TACCTGAGATTTTATTTTGAGATACCATCAGGGTGAGTTGCACCACTTGTACTCAATTCTAATTGCCCCCTGGCAATCTGGGAAGGGTTC
AGAAGGTGGGCACCCAGCCAACAGCATGAACTCAGAGCATTGTTTTAGGGTTGGAGGAGGAACACGCTTTCTTTACATCACTAGTGTAGA
CTCAAAAGATATGCAAGTGTCAAATATGCAAAAGAAATAGTTTATTCAAAGAGACTGTGTGTTACTGAAGAACAGCATAAAAATATGATT
TTTTTACTTGCAAAAATGAAAGGAAAAAAATACCACGCATTGAAATGCCCAGTTCAGACTGAATAATTCCTGCTGCAGCAAGGAAAGTAC
CTACTATAATAGAAATTCTGTTTTGTTTTCTGTGGTTTTCAAGTTAAAAAAAAAAAAGTTAAAATAAAAAGCACTTTATGTTTTTCAAAA
ATAGGTTCTGCCAGGGACAGTGTCAACATCTTGCACTTTAAAATAAGCACTATTTCCCATAGCCCAATTGTTGGGACTGTAGTTGGATTG
TTGCTACCTGCCCATTTCTGGCCAGCATGGGTAATATTGTGCTGGTATTACTGTCTGCCATATCAAAGTCTGTGGGCTCCTTCCCTGCCC
CTCTGAAACCTTCCCTTAACCCTCATGGGTCAGGAGGGGTTCTTGCCCCTTGGGTGGGGCCTCTCATGAAGTCAAGTATACAGGAGACAT
GCACATCTCAAAAGGACACAGTGACAGTTGGACATTGGGTGTTTTACTCTGTTCTCTTTCTTGTCAACCAGCTATTGGTTTTTCAGTGTC
ACTGTCTGTACTAAAAGCTCAACTCTCCTTCCTGCAGCCATCGATGCAGCCAGTACAGACAAAAGCAATAAGTATTTGTGTGCATCCTGA
GTGGTTCTGGTGTATTTCTTGGTGTTGGTTTTCCTGTCCTCGTTTGATGACCTGGCATTGTCCTGCCTGCTTTTAGTCCAACAGCATGGT
GTTGTTGGCCATTCCTCAGTACAGTGGCATTAGGTTGAACCACTGATGAATACAATGCTATAGTGTTGGCTCACCTGTCAGTAAAGATGA
CATGTTATTGGTCTGCCTGTCTGTAGTACAATGGAACAATGTTGTTCTCTTAATGTAATGTTGATGGATGATGTCCCAAGTACAATAGTG
TAGTTCTGTCTATCCTCAATACAGTAACAGGCATATGTCTTCCCAGTGGAAGAAAGATATGGTATTGGTTCACCTAGTCTTAAGTCTCAA
TATCATCTGTTGCTGGTCTGCCTGTTAGTACAATGGCATGATCCACCTCTCAGTACACAAATATCATGGAGCTGTTCTGCCTGCTCTTCA
TACATAAGGCATAAGGTTGAGCCACCTGCCACACATATGATGAGATGGGATCATTCCACCACCCTTAAAAATATGTCTTCTCTGCTGTAT
ACAAACCCAATTCATAACACTTCTCAGCATCTCCAGAGACTGTAGATCCCCCCAAGAGGGTGCAGTCCTGTTCTTTGCCGCATTAACAGA
GAAAACGAGAACGTCACTCTTCCTAGGTATCTTCAGAGTATTCGCGCAGCAACTGCAAAGGGACTTAGGGGCAGGGAGAGTGTGAGGTCA
TCCCGTGCCAGGCAGAGGAAGCAGCACTCCCAAAACACTTTGCTGAACACGCAGTCTGAGCTGGGGGCCTCTTGAGGAATGACTGTGGGA
CAGTTCTCCGCCGACCATCTCACATGTCTCTTCTTTGTTTTCATCACCATTAATGTCCACCATCAGCACAAATGTGAAAATTCAGGGAAA
AAAACAAATGCTTTTTGATAAAAGTAAATAGTTGTGATTTCCAATTCAGATATTTTTAGAGCTGATGCTATCTGTAAAAAATAATAATAA
TAATAATATAGTCTATTTTACATATCAGGAAAGTGAACATGTTTCAATATAGCCATATATATTGAGAAGGAACTTACCACCCCTTCTTCC
AATCGAGGCATTTCATTTGTTGGTTGAAGCAGATGAGAACTGTACAGATTGAAAATGATTTGTTTTTTTTTTTTTTTAAAAAAAACGAAA
ACCAATTGGTGCAACTCTCCTTGTAACCAAAGGCCCTTTCTGCCTTCTGTGGTCATGTAGGACCTGGCCCTTCCTTCCTTGTGTATTTTG
TCCAACCGTAAAGTAGCATTTTATTGAGTCACTTTTGAAGGACGAATTCAGAAGTATCATTAAGAACCTACCTTTTCAGGCTTCATAGCC
AGAGTCCTATAGAGTTCTTATAGAAACAGAATAATTGAAATTCAGCATATACTATGCTTAGAAAGTATTTTGTTTGGGTTTGATTGGGTT
TTTTTTTCTTTTACTTGTGTGTGTATGTACTGGGGGAGTATAGCTTTTATTCTGTGCTCAATTCGAAAGAGAGTATTATAAGTTTTCCCA
GCCCATCCACCCGCTAAAAAAGAACATATCCAAATTTTAATATGTATACACCCAACCTGTACCTATGTACGTGAATATACATGCACTGGG
AAATCTACTTAAGAGTCTTCACTGAGAAGTTCACTCGATAGAAAGGTCTTGATAGAGAAGAGAAGAGGAAAGCAATGGTCTGAAGGCAAA
TCCTGCTTTAACTTGGTGGTCCATTTCCCATTCATTCCTGAACCAATGAGAGCAGAAAGAAACAAGTCAACCCAAACAAGCAAACTAGGG
GCTGGACGCGGCGAATGGATGCTGGTCAGTTTGGCAAATTCACTGAAACTCATCAAGAACCCAGCTGAACTTGCATTCCAACTTCCACAA
TTATCTGAAAGGGCTAGGGACCAGGTAGCCATGTGTCCCAATCACACGGGGGAGAGTCTGCCACCGGCGGTGAGAGAGGTGGGGAAGCTT
TGGAGGAGACAGTATATTCACCTTTTTATCTTTGGGTAAAAGAAACCAACAGGACTTTGGTGCAGTAGATTTCTCAGTGCCTTCTTTAGG
AATTCTATCTTAAGCACACTTCAAGGGGAAAGAAAAAAGGAGGAGAGAACATTTGTTCCCGTGAAGTCCCTTTCTCCAAAGGACTGGGGA
TCAAGAAGGAAGAAGAGTAAGAAGGAAAAACAACAAAATCCTGAGGAGGCCATTTCTTTTAACCCACCCAGCTTGCCCCTGAAAACTGCT
GGTGATACAAACTTTTTCAAACTGACTTCCAGCTTCTCCATGTGTCTTGGTAACTGTAGCCTCGTCTCTGCCCTTTCTCCTAATAAGATC
CATGTTTCTAAGGAGAAAAACAAAACAGTATTCTCTTCTGTAAAACTGTAATGTATTGTTGATATTTGTAACTATTGTATATTTCTGTCT
TGCTCCAGTCCCAGCTGGAGTGTCTAGTTCCATGGACAAGGGGATATTTAAAATTCACCACGGACAAGAGCCACTAAAGCCAGGTCTCTA
TCGCTAATCTCTCTCCTATTCTTATTTCTCTACCAACTAATCTCAAGTAACAATACCCCAGGCTTTTTTTCAGCCTCAATTCAAGTAACT
TTGAATCAAAAGAGAGCAAGGCAAAAAGCCTCCGGACATGCTTCTTTGGGAAAGGACTTTTTCTGTAGCTGCAGAGTGGGCAGGAGGGAG
AAGGGGCTCCCCTGAGACCCCGGCAGGACAATGGAAAGCTTCCAGCCCCGAGCTGATGTTTCCTCACCTATCACTGCTTATAGGACAGCA
TCCAAATGCTTTCATGTCACTCAGCCCAGGCAACCCAAACCAGTCCTGGCTACACCCAGAAATAAGAGTTACCTCTGCATTTTCTGTTGC
CATTTTTCTGGCTCTAGAAGTATCTGATGCGCGACTATGTCATAGAATGTCCACGCATCTCAGAGTAGTCTATTTTTCTGTTCAGATAAA
ATATATATATATATGTATTTTTAGCAAATTTATAATAGGGCAATTGAGTCTAATTTCTTCTTTTGTAATACAGAACAATATCTTAGGAGT
TTCATTGTTGGTCATTATCGTAGCTGATGTTTTCTGGTCTTTTGCAGTTCCTACCATTGTCCCTTGGGCTGTTTGGGTTTTCTTCCTTTT
GATTCTGATTTCTTGAGGGTGGGGAAAGACTTTGGGGTTTGACTTCCTTGTGTAGGCATTTCTTGACACTAGGCCTGGACTCTGTCAATG
CTGTGACTTTCCTCATTCATTTCTGTGTGTTTCTCCCATTCGTTGTTCTTAAGAATCCAGGGCATGAATGCAGGAATGAGACCCAGGGAA
GCAGAGCTACAGATGGCCCTCAAAATCAGGATGGGATGTGGGCTGGTTTCACTTATATCCCACACCCCTTTAGGGATCTGAAGGGACTGA
GTTTTCTCATCCCCAGAGATCTTGGAACCAAAAATCTCATGCAAGCAAACTCATCACTGGCATTTCTGAGATCCAGAACACATGTGAGTC
CCTCCTGGCTGGGCTGCTCCCACATGTCCAGCACCCTGTCGGCCTGTAACATCAATCAGAGCTGAAGGTCAGAGGTTTTTCAGGTTCTCG
TGAACCTCACAAGAACATGCTGGGCCTCCGATCTCACCAACTTGTTTATCAGTTCCTTGTTTCGATCTGTTTATTTATTTATTTTTTTGT
TATTATTATTTTGAGACAAAGTCTTGCTCTGTTGCCCAGGCTGCAGTGCAATGGCGCAATCTCGGCTCACTGCAACCTCCTCCACCCAGG
TTCAAGTGATTCTCATGTCTCAGCCTCCTGAGTAACTGGGATTACAAGAGCGCACCATCACGCCCAGCTAATTTTTGTATTTTTAGTAGA
GGCAGAGTTTCTCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAGTGCTAGGATTACAG
GTGTGAGCCACCACTGCACCCAGTCCATTTCAATCCATTTCTAACAGCTTCACCAAAAAACAGTGGCCAGACACCCTTGCAGCCAAACCC
TGAGAAGAGATGTCCCCGAATCTGCTAGCTCATCTCCCCTTCCCTTGCCAGCTGCCTGGCTCCATAGAGCAGGAGGTGTGTGGCAAGGAC
AGGGGCAGTTTTCCAGCTTCCACCTATCCACGCCTGGGGGAGTTTTTGGACTGTCCTGATAATTAATTCCAGAGGCAGTTTTCAGTCCTG
GGTGGGCGGAGGACATCTCACTAGGCAGGATCTTCAGCAGAAAGTGATTCTCCATCCGTCAACTCATGCAGGAAGATGAAGAAAGCCCAG
ATAATCTCCAACTTGCATTCGTTTAGGTTTTGGTATACCACCCACCTCACTGTCAGCTGCAGGGCTTGGGGCTCTGCCTAGAATCAGAAA
TTTGAGCCAAACTGGGACCCTCAGATGGCAGTGAGCCATCCCATCAGATAACTCCCAAGAGGAAGCCAACTCAAATATGAATTTTATTAT
TCTGGACTATGACCCTGATCAGAGTTCTCCCACCCCGAAAACCTCTGATAGTCTGGTTTGAACCAGAGTCAAATAAAACAGACAAGATTT
TTTTTTCCTCTGCACAAAAGCAAAAAAACAAAACAAAAAAAAGTCTGCCAGTAGTTTCCTGGGTTTGATGCCCAGATAAGCAAACACTGT
TGCCTATGGCTGTTGCTGTTTTCATCAAGAAAGAGGTTATATAGTTTGCATTTCCATCCACTCTCCCTGATTTTATCTTAACCTAGAATT
TCTCCTGAACTACCCCAAATGCCAACTTGAATTTGGGTAGGGCTCTGTTAATCGAGGGAACCCTCATCTTCACTTATAAACCTAATTCTC
TGTTCCTCCCTCCAAAGATCCTGAAAAGATCTCCTAAAGGCTGGCCAGGATGGGGTGGAGTGGGGCAGTGCACCTGAAGAAAAAAACTTA
GCTGCCAGCTGGCTGTATGCAAGTTCTCCGAAAATTTCTATTGTATGAAAGGGATGGGGTCAATTGCAGCTCAAATTAAGGAAGCCCTCC
TAACAGGCTGGGTTGTCTGACCATGGAGCTCAATGCCATGGTGGACAGTGAGCTCCCTTATATCACAGGTGTTTAAAGAGAGGCTGGCTA
GATGGTGTAAAAAATGGGCATTGCAGAGGGGCCCTAGCATTGCATGGAAACTGGGCTGAACAACCACAGAAATTCCTCTTTGTTTCTTGG
AGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAGGTGGTTTCAACACTCTGGATATAAGCTCAAGCCACTGAGGCAA
AGGCATGCAGCACAATTAGCAGGAATGCAACTTCTGGGCTTTGGAGCTCTCAGAGGGGGTGTCCAAGAGACAAGTCTGCTTCCTTCCGGC
TCCGTCTTGGAACATTTTAATGACTGTCAGTCACCAATCCAACCCATCCCCAGTGGCCTACCAGGCACCACATTGGGATGAGACTCATGC
TACCCTTCCCCAGGCCAGCCAAGGAGCAATCCACGCTGTCCCCCATCCCTGGCTGGCTGTCTTATGGTGCTTCAGCCCCTCCGCCCAGCT
CCTGTGCCCTCATGAGCCTGGGGCTTTCTGTATAAAAGATGCAATGATATCTGTTCCCCACTAGCCATCCCCACAATGAACAACTTCCCA
GGCAATAGCAAATGGCTCCATTCCAAAAGGGCTTGTTTTTTTGGTAAATCAAATAAGAGACCCCACTCAAGACCTTTGAAAGTCCCCGTC
AATGAAAAAAATCCAGAAGGGTCAAAAGAGAAAGGCAGCTTTTAATCCAGTTTCACAGCAAAACCAGGCTCTTGGCTGCCTCCAAGCAGA
ATGCCACTCTCCTGCAGCTGTGGCCTCCATCCCAAATCATCCTGCATACTGCATTCTCTAAGGAAAGCATTTGACAAGAGAGGGTTTATG
TATGGTGGATTGGGAGAAAGTGAGACTTCAACCTCAGGGTGAACCGAAGACTGGTTTGTCTTTGGTTGTTTTAGTATGAGGTTGGGCAGG
ATGATATGTTTGGATGGGTAGAATGAGCAGCCGCCTTCCTCTGAAACCAAAATAAAATAAAAACCAGTTTTCAAGATTCCTCCCAACTCC
TCACTGGAGGCTCTGCCCTGCAGAATCACTCAAGTTGCAACAACACAAGGAGACAAAAATAGGATATTTCATGAAAATATAAGAAACTCC
CAATTCCGTCCCATTAGGATGCCCTCAAGGGGCCATGCAGGGATCTTCCCATACTTCCTGCTTCCCTGATCTGAACCAAGATTGGAAAGA
GGCAGGCAGCAGAGAAGATGCCCAAGAAACTCTGACATATCCACAGCTTGGCTCTGCCCCTTGGGCTTCACTGGGGTTTGGGCCTCCCTC
TTGGTTGAGCTGAGTGTGCCTGAGTGGGTGGGGACAGGGAGGATTCTCCAGGTCTATCTTGATTTCATAGGTCCTTCTCAATCCAAGGTC
AAAAACTGAGAATCTTATTTTCTGCACCAGGAACTCAGGGTTATCCCCAACCTATGCCGCTGGCACATGATGGTCATCCAACCTGTGTTT
TTGTGAGTGAGTGAATGTGTGACTGGTTGGCCTCTGAGTGGATGACTGGATGCGTGAATGTGTGAGTGAATGGGGGAGTTAATGAATCCC
TACCTAACTGTGAAGAGAAGAAAAATGAGGAGCCCCTCTCCCACTGAAACCCATAACTGCCCCATCAAGGTCATCTTTCTTTGACTCAAG
ATGACATCTCAATTTGATGCTTGTAGGCCCCAAGCTGATAAGGGCCACAGCCCTCTCAGAGCCACACTTCCTGGGGGCCCACAGAGCAGC
TCTGCCCTCCTTCCTCTTCCCCTACCCTGCATTTCTCAGCCTCATGTTCTATTTTAGCTCACACACGACCCATGGGGGGGACCACCAAGT
GGTTTTCCAATGGACTAAGCCAAGGGTTCGAAGTTGGGACTTCCTTTGGTCTGGGACTTCCTGGGGCAGAAACATAGGAGCCAACATCTG
GAAACTGGATTGCATTCCCTGAGCCATGGGAGTCCAGCTGGATATTAAGGCCAGCCTGCCCTCCAGCTTTTAGAGCCGAAGATCTTTTTT
TCTGAGCCCCAAAGCCGTCATGATAGTATGCCCCCAGATCCCATCAGCTAAGACCCTGTCTCTCCCAGGAACCCGTCGTGTGAGGTTGGG
GCTTTTCTGCCAGTAAAGCCATTCTGATCACCTCACCCTTGACAGGGGCCAAGCCAATCACATTAGCCATAAATGACCAATGTCCTCAGC
CACTCTTTTCTCGGGGGTGCATTCGTGGGTCCTATTCATCTCTCGTCAGTTAATGTCTCTAGTCCTTCCTGTAAAGGTGAAAATAAGCAT
TGCGCATGTGCGCAACACACACGCACACACACACACACACACACACACACAAATCCCAGTGTCTTTTTATGCATGTGGTGAGATGAAATT
GTGATCTTTGTGTGACCTCCAGCTGCTGTCTTGTCTTGTAAAATATGTCCAAATGTTTAAGAATTTCTAAGCAAATGGTCCCTTAATGAA

>94346_94346_2_TRPC4AP-KCNB1_TRPC4AP_chr20_33657099_ENST00000451813_KCNB1_chr20_47991529_ENST00000371741_length(amino acids)=814AA_BP=145
MFVRRGDMAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHT
TSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDILAIISIMFIVLSTIALSLNTLPELQSLDEFGQST
DNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHS
TGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV
IALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKRT
LSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRS
MSSIDSFISCATDFPEATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSSMKTNNPLKLRALKV
NFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEG
QLLYSVDSSPPKSLPGSTSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPDVRVLPGGGAHGSTR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TRPC4AP-KCNB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRPC4APchr20:33657099chr20:47991529ENST00000252015-3192_400138.0798.0TNFRSF1A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TRPC4AP-KCNB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TRPC4AP-KCNB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource