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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRPS1-LRP12 (FusionGDB2 ID:94430)

Fusion Gene Summary for TRPS1-LRP12

check button Fusion gene summary
Fusion gene informationFusion gene name: TRPS1-LRP12
Fusion gene ID: 94430
HgeneTgene
Gene symbol

TRPS1

LRP12

Gene ID

7227

29967

Gene nametranscriptional repressor GATA binding 1LDL receptor related protein 12
SynonymsGC79|LGCRMIG13A|ST7
Cytomap

8q23.3

8q22.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger transcription factor Trps1tricho-rhino-phalangeal syndrome type I proteintrichorhinophalangeal syndrome Izinc finger protein GC79low-density lipoprotein receptor-related protein 12LDLR-related protein 12suppressor of tumorigenicity 7 protein
Modification date2020031320200313
UniProtAcc.

Q9Y561

Ensembl transtripts involved in fusion geneENST00000220888, ENST00000395715, 
ENST00000519076, ENST00000519674, 
ENST00000520276, 		ENST00000518375, 
ENST00000276654, ENST00000424843, 
Fusion gene scores* DoF score27 X 17 X 6=27545 X 3 X 5=75
# samples 316
** MAII scorelog2(31/2754*10)=-3.15118843886073
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRPS1 [Title/Abstract] AND LRP12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRPS1(116599228)-LRP12(105521302), # samples:1
Anticipated loss of major functional domain due to fusion event.TRPS1-LRP12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TRPS1-LRP12 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TRPS1-LRP12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRPS1

GO:0000122

negative regulation of transcription by RNA polymerase II

12885770|21673316

TgeneLRP12

GO:0001764

neuron migration

26639854

TgeneLRP12

GO:0031175

neuron projection development

26639854


check buttonFusion gene breakpoints across TRPS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRP12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A5XU-01ATRPS1chr8

116599228

-LRP12chr8

105521302

-


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Fusion Gene ORF analysis for TRPS1-LRP12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000220888ENST00000518375TRPS1chr8

116599228

-LRP12chr8

105521302

-
5CDS-intronENST00000395715ENST00000518375TRPS1chr8

116599228

-LRP12chr8

105521302

-
5CDS-intronENST00000519076ENST00000518375TRPS1chr8

116599228

-LRP12chr8

105521302

-
5CDS-intronENST00000519674ENST00000518375TRPS1chr8

116599228

-LRP12chr8

105521302

-
5CDS-intronENST00000520276ENST00000518375TRPS1chr8

116599228

-LRP12chr8

105521302

-
Frame-shiftENST00000220888ENST00000276654TRPS1chr8

116599228

-LRP12chr8

105521302

-
Frame-shiftENST00000220888ENST00000424843TRPS1chr8

116599228

-LRP12chr8

105521302

-
Frame-shiftENST00000519076ENST00000276654TRPS1chr8

116599228

-LRP12chr8

105521302

-
Frame-shiftENST00000519076ENST00000424843TRPS1chr8

116599228

-LRP12chr8

105521302

-
Frame-shiftENST00000519674ENST00000276654TRPS1chr8

116599228

-LRP12chr8

105521302

-
Frame-shiftENST00000519674ENST00000424843TRPS1chr8

116599228

-LRP12chr8

105521302

-
Frame-shiftENST00000520276ENST00000276654TRPS1chr8

116599228

-LRP12chr8

105521302

-
Frame-shiftENST00000520276ENST00000424843TRPS1chr8

116599228

-LRP12chr8

105521302

-
In-frameENST00000395715ENST00000276654TRPS1chr8

116599228

-LRP12chr8

105521302

-
In-frameENST00000395715ENST00000424843TRPS1chr8

116599228

-LRP12chr8

105521302

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395715TRPS1chr8116599228-ENST00000424843LRP12chr8105521302-716432785783322914
ENST00000395715TRPS1chr8116599228-ENST00000276654LRP12chr8105521302-714532785783322914

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395715ENST00000424843TRPS1chr8116599228-LRP12chr8105521302-0.0001435970.99985635
ENST00000395715ENST00000276654TRPS1chr8116599228-LRP12chr8105521302-0.0001456540.9998543

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Fusion Genomic Features for TRPS1-LRP12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRPS1-LRP12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:116599228/chr8:105521302)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRP12

Q9Y561

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. {ECO:0000269|PubMed:12809483}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRPS1chr8:116599228chr8:105521302ENST00000220888-46222_2478871282.0Zinc fingerC2H2-type 1%3B atypical
HgeneTRPS1chr8:116599228chr8:105521302ENST00000220888-46333_3588871282.0Zinc fingerC2H2-type 2%3B atypical
HgeneTRPS1chr8:116599228chr8:105521302ENST00000220888-46614_6378871282.0Zinc fingerC2H2-type 3%3B atypical
HgeneTRPS1chr8:116599228chr8:105521302ENST00000220888-46666_6898871282.0Zinc fingerC2H2-type 4
HgeneTRPS1chr8:116599228chr8:105521302ENST00000220888-46692_7158871282.0Zinc fingerC2H2-type 5
HgeneTRPS1chr8:116599228chr8:105521302ENST00000395715-57222_2479001295.0Zinc fingerC2H2-type 1%3B atypical
HgeneTRPS1chr8:116599228chr8:105521302ENST00000395715-57333_3589001295.0Zinc fingerC2H2-type 2%3B atypical
HgeneTRPS1chr8:116599228chr8:105521302ENST00000395715-57614_6379001295.0Zinc fingerC2H2-type 3%3B atypical
HgeneTRPS1chr8:116599228chr8:105521302ENST00000395715-57666_6899001295.0Zinc fingerC2H2-type 4
HgeneTRPS1chr8:116599228chr8:105521302ENST00000395715-57692_7159001295.0Zinc fingerC2H2-type 5
HgeneTRPS1chr8:116599228chr8:105521302ENST00000520276-46222_2478911286.0Zinc fingerC2H2-type 1%3B atypical
HgeneTRPS1chr8:116599228chr8:105521302ENST00000520276-46333_3588911286.0Zinc fingerC2H2-type 2%3B atypical
HgeneTRPS1chr8:116599228chr8:105521302ENST00000520276-46614_6378911286.0Zinc fingerC2H2-type 3%3B atypical
HgeneTRPS1chr8:116599228chr8:105521302ENST00000520276-46666_6898911286.0Zinc fingerC2H2-type 4
HgeneTRPS1chr8:116599228chr8:105521302ENST00000520276-46692_7158911286.0Zinc fingerC2H2-type 5
TgeneLRP12chr8:116599228chr8:105521302ENST0000027665417165_20145860.0DomainLDL-receptor class A 1
TgeneLRP12chr8:116599228chr8:105521302ENST0000027665417214_25545860.0DomainLDL-receptor class A 2
TgeneLRP12chr8:116599228chr8:105521302ENST0000027665417259_37245860.0DomainCUB 2
TgeneLRP12chr8:116599228chr8:105521302ENST0000027665417374_41145860.0DomainLDL-receptor class A 3
TgeneLRP12chr8:116599228chr8:105521302ENST0000027665417412_44945860.0DomainLDL-receptor class A 4
TgeneLRP12chr8:116599228chr8:105521302ENST0000027665417450_48645860.0DomainLDL-receptor class A 5
TgeneLRP12chr8:116599228chr8:105521302ENST000002766541747_15945860.0DomainCUB 1
TgeneLRP12chr8:116599228chr8:105521302ENST0000042484306165_20126841.0DomainLDL-receptor class A 1
TgeneLRP12chr8:116599228chr8:105521302ENST0000042484306214_25526841.0DomainLDL-receptor class A 2
TgeneLRP12chr8:116599228chr8:105521302ENST0000042484306259_37226841.0DomainCUB 2
TgeneLRP12chr8:116599228chr8:105521302ENST0000042484306374_41126841.0DomainLDL-receptor class A 3
TgeneLRP12chr8:116599228chr8:105521302ENST0000042484306412_44926841.0DomainLDL-receptor class A 4
TgeneLRP12chr8:116599228chr8:105521302ENST0000042484306450_48626841.0DomainLDL-receptor class A 5
TgeneLRP12chr8:116599228chr8:105521302ENST000004248430647_15926841.0DomainCUB 1
TgeneLRP12chr8:116599228chr8:105521302ENST0000027665417514_85945860.0Topological domainCytoplasmic
TgeneLRP12chr8:116599228chr8:105521302ENST000004248430633_49226841.0Topological domainExtracellular
TgeneLRP12chr8:116599228chr8:105521302ENST0000042484306514_85926841.0Topological domainCytoplasmic
TgeneLRP12chr8:116599228chr8:105521302ENST0000027665417493_51345860.0TransmembraneHelical
TgeneLRP12chr8:116599228chr8:105521302ENST0000042484306493_51326841.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRPS1chr8:116599228chr8:105521302ENST00000220888-461163_12818871282.0RegionTranscriptional repressor domain
HgeneTRPS1chr8:116599228chr8:105521302ENST00000395715-571163_12819001295.0RegionTranscriptional repressor domain
HgeneTRPS1chr8:116599228chr8:105521302ENST00000520276-461163_12818911286.0RegionTranscriptional repressor domain
HgeneTRPS1chr8:116599228chr8:105521302ENST00000220888-461215_12378871282.0Zinc fingerC2H2-type 6
HgeneTRPS1chr8:116599228chr8:105521302ENST00000220888-461243_12678871282.0Zinc fingerC2H2-type 7
HgeneTRPS1chr8:116599228chr8:105521302ENST00000220888-46896_9208871282.0Zinc fingerGATA-type
HgeneTRPS1chr8:116599228chr8:105521302ENST00000395715-571215_12379001295.0Zinc fingerC2H2-type 6
HgeneTRPS1chr8:116599228chr8:105521302ENST00000395715-571243_12679001295.0Zinc fingerC2H2-type 7
HgeneTRPS1chr8:116599228chr8:105521302ENST00000395715-57896_9209001295.0Zinc fingerGATA-type
HgeneTRPS1chr8:116599228chr8:105521302ENST00000520276-461215_12378911286.0Zinc fingerC2H2-type 6
HgeneTRPS1chr8:116599228chr8:105521302ENST00000520276-461243_12678911286.0Zinc fingerC2H2-type 7
HgeneTRPS1chr8:116599228chr8:105521302ENST00000520276-46896_9208911286.0Zinc fingerGATA-type
TgeneLRP12chr8:116599228chr8:105521302ENST000002766541733_49245860.0Topological domainExtracellular


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Fusion Gene Sequence for TRPS1-LRP12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94430_94430_1_TRPS1-LRP12_TRPS1_chr8_116599228_ENST00000395715_LRP12_chr8_105521302_ENST00000276654_length(transcript)=7145nt_BP=3278nt
AATAGTGTTGGTGTCTTGAAACTGACGTAATGCGCGGAGACTGAGGTCCTGACAAGCGATAACATTTCTGATAAAGACCCGATCTTACTG
CAATCTCTAGCGTCCTCTTTTTTGGTGCTGCTGGTTTCTCCAGACCTCGCGTCCTCTCGATTGCTCTCTCGCCTTCCTATTTCTTTTTTT
TTTTTTTAAACAAAAAACAACACCCCCTCCCCTCTCCCACCCGGCACCGGGCACATCCTTGCTCTATTTCCTTTCTCTTTCTCTCTCTCT
CTCTCTCTCTCTCTTTTTTAATAAGGGTGGGGGAGGGAAAGGGGGGGGAGGCAGGAAAGACCTTTTTCTCTCCCCCCCGCAATAATCCAA
GATCAACTCTGCAAACAACAGAAGACGGTTCATGGCTTTGGCCGCCGCGCCACCATCTTTCGGGCTGCCGAGGGTGTTCTTGACGATTAA
TCAACAGATGTACAGATCAGCTCTCAAAATGTCTTCTGTGTCTTCTGAGCGTCTTCTAAGACAATTGCATTAGCCTCCTGCTAGTTGACT
AATAGAATTAATAATTGTAAAAAGCACTCTAAAGCCACATGCCTTATGAAGTCAATGCTGGGTATGATTTTACAAATATGGTCCGGAAAA
AGAACCCCCCTCTGAGAAACGTTGCAAGTGAAGGCGAGGGCCAGATCCTGGAGCCTATAGGTACAGAAAGCAAGGTATCTGGAAAGAACA
AAGAATTTTCTGCAGATCAGATGTCAGAAAATACGGATCAGAGTGATGCTGCAGAACTAAATCATAAGGAGGAACATAGCTTGCATGTTC
AAGATCCATCTTCTAGCAGTAAGAAGGACTTGAAAAGCGCAGTTCTGAGTGAGAAGGCTGGCTTCAATTATGAAAGCCCCAGTAAGGGAG
GAAACTTTCCCTCCTTTCCGCATGATGAGGTGACAGACAGAAATATGTTGGCTTTCTCATCTCCAGCTGCTGGGGGAGTCTGTGAGCCCT
TGAAGTCTCCGCAAAGAGCAGAGGCAGATGACCCTCAAGATATGGCCTGCACCCCCTCAGGGGACTCACTGGAGACAAAGGAAGATCAGA
AGATGTCACCAAAGGCTACAGAGGAAACAGGGCAAGCACAGAGTGGTCAAGCCAATTGTCAAGGTTTGAGCCCAGTTTCAGTGGCCTCAA
AAAACCCACAAGTGCCTTCAGATGGGGGTGTAAGACTGAATAAATCCAAAACTGACTTACTGGTGAATGACAACCCAGACCCGGCACCTC
TGTCTCCAGAGCTTCAGGACTTTAAATGCAATATCTGTGGATATGGTTACTACGGCAACGACCCCACAGATCTGATTAAGCACTTCCGAA
AGTATCACTTAGGACTGCATAACCGCACCAGGCAAGATGCTGAGCTGGACAGCAAAATCTTGGCCCTTCATAACATGGTGCAGTTCAGCC
ATTCCAAAGACTTCCAGAAGGTCAACCGTTCTGTGTTTTCTGGTGTGCTGCAGGACATCAATTCTTCAAGGCCTGTTTTACTAAATGGGA
CCTATGATGTGCAGGTGACTTCAGGTGGAACATTCATTGGCATTGGACGGAAAACACCAGATTGCCAAGGGAACACCAAGTATTTCCGCT
GTAAATTCTGCAATTTCACTTATATGGGCAACTCATCCACCGAATTAGAACAACATTTTCTTCAGACTCACCCAAACAAAATAAAAGCTT
CTCTCCCCTCCTCTGAGGTTGCAAAACCTTCAGAGAAAAACTCTAACAAGTCCATCCCTGCACTTCAATCCAGTGATTCTGGAGACTTGG
GAAAATGGCAGGACAAGATAACAGTCAAAGCAGGAGATGACACTCCTGTTGGGTACTCAGTGCCCATAAAGCCCCTCGATTCCTCTAGAC
AAAATGGTACAGAGGCCACCAGTTACTACTGGTGTAAATTTTGTAGTTTCAGCTGTGAGTCATCTAGCTCACTTAAACTGCTAGAACATT
ATGGCAAGCAGCACGGAGCAGTGCAGTCAGGCGGCCTTAATCCAGAGTTAAATGATAAGCTTTCCAGGGGCTCTGTCATTAATCAGAATG
ATCTAGCCAAAAGTTCAGAAGGAGAGACAATGACCAAGACAGACAAGAGCTCGAGTGGGGCTAAAAAGAAGGACTTCTCCAGCAAGGGAG
CCGAGGATAATATGGTAACGAGCTATAATTGTCAGTTCTGTGACTTCCGATATTCCAAAAGCCATGGCCCTGATGTAATTGTAGTGGGGC
CACTTCTCCGTCATTATCAACAGCTCCATAACATTCACAAGTGTACCATTAAACACTGTCCATTCTGTCCCAGAGGACTTTGCAGCCCAG
AAAAGCACCTTGGAGAAATTACTTATCCGTTTGCTTGTAGAAAAAGTAATTGTTCCCACTGTGCACTCTTGCTTCTGCACTTGTCTCCTG
GGGCGGCTGGAAGCTCGCGAGTCAAACATCAGTGCCATCAGTGTTCATTCACCACCCCTGACGTAGATGTACTCCTCTTTCACTATGAAA
GTGTGCATGAGTCCCAAGCATCGGATGTCAAACAAGAAGCAAATCACCTGCAAGGATCGGATGGGCAGCAGTCTGTCAAGGAAAGCAAAG
AACACTCATGTACCAAATGTGATTTTATTACCCAAGTGGAAGAAGAGATTTCCCGACACTACAGGAGAGCACACAGCTGCTACAAATGCC
GTCAGTGCAGTTTTACAGCTGCCGATACTCAGTCACTACTGGAGCACTTCAACACTGTTCACTGCCAGGAACAGGACATCACTACAGCCA
ACGGCGAAGAGGACGGTCATGCCATATCCACCATCAAAGAGGAGCCCAAAATTGACTTCAGGGTCTACAATCTGCTAACTCCAGACTCTA
AAATGGGAGAGCCAGTTTCTGAGAGTGTGGTGAAGAGAGAGAAGCTGGAAGAGAAGGACGGGCTCAAAGAGAAAGTTTGGACCGAGAGTT
CCAGTGATGACCTTCGCAATGTGACTTGGAGAGGGGCAGACATCCTGCGGGGGAGTCCGTCATACACCCAAGCAAGCCTGGGGCTGCTGA
CGCCTGTGTCTGGCACCCAAGAGCAGACAAAGACTCTAAGGGATAGTCCCAATGTGGAGGCCGCCCATCTGGCGCGACCTATTTATGGCT
TGGCTGTGGAAACCAAGGGATTCCTGCAGGGGGCGCCAGCTGGCGGAGAGAAGTCTGGGGCCCTCCCCCAGCAGTATCCTGCATCGGGAG
AAAACAAGTCCAAGGATGAATCCCAGTCCCTGTTACGGCTTGTGGAGAGACTCCAGAGCAAATACGAGCACCAAGTGGCATAATCACAAG
CCCAGGCTGGCCTTCTGAATATCCTGCAAAAATCAACTGTAGCTGGTTCATAAGGGCAAACCCAGGCGAAATCATTACTATAAGTTTTCA
GGATTTTGATATTCAAGGATCCAGAAGGTGCAATTTGGACTGGTTGACAATAGAAACATACAAGAATATTGAAAGTTACAGAGCTTGTGG
TTCCACAATTCCACCTCCGTATATCTCTTCACAAGACCACATCTGGATTAGGTTTCATTCGGATGACAACATCTCTAGAAAGGGTTTCAG
ACTGGCATATTTTTCAGGGAAATCTGAGGAACCAAATTGTGCTTGTGATCAGTTTCGTTGTGGTAATGGAAAGTGTATACCAGAAGCCTG
GAAATGTAATAACATGGATGAATGTGGAGATAGTTCCGATGAAGAGATCTGTGCCAAAGAAGCAAATCCTCCAACTGCTGCTGCTTTTCA
ACCCTGTGCTTACAACCAGTTCCAGTGTTTATCCCGTTTTACCAAAGTTTACACTTGCCTCCCCGAATCTTTAAAATGTGATGGGAACAT
TGACTGCCTTGACCTAGGAGATGAGATAGACTGTGATGTGCCAACATGTGGGCAATGGCTAAAATATTTTTATGGTACTTTTAATTCTCC
CAATTATCCAGACTTTTATCCTCCTGGAAGCAATTGCACCTGGTTAATAGACACTGGTGATCACCGTAAAGTCATTTTACGCTTCACTGA
CTTTAAACTTGATGGTACTGGTTATGGTGATTATGTCAAAATATATGATGGATTAGAGGAGAATCCACACAAGCTTTTGCGTGTGTTGAC
AGCTTTTGATTCTCATGCACCTCTTACAGTTGTTTCTTCTTCTGGACAGATAAGGGTACATTTTTGTGCTGATAAAGTGAATGCTGCAAG
GGGATTTAATGCTACTTACCAAGTAGATGGGTTCTGTTTGCCATGGGAAATACCCTGTGGAGGTAACTGGGGGTGTTATACTGAGCAGCA
GCGTTGTGATGGGTATTGGCATTGCCCAAATGGAAGGGATGAAACCAATTGTACCATGTGCCAGAAGGAAGAATTTCCATGTTCCCGAAA
TGGTGTCTGTTATCCTCGTTCTGATCGCTGCAACTACCAGAATCATTGCCCAAATGGCTCAGATGAAAAAAACTGCTTTTTTTGCCAACC
AGGAAATTTCCATTGTAAAAACAATCGTTGTGTGTTTGAAAGTTGGGTGTGTGATTCTCAAGATGACTGTGGTGATGGCAGCGATGAAGA
AAATTGCCCAGTAATCGTGCCTACAAGAGTCATCACTGCTGCCGTCATAGGGAGCCTCATCTGTGGCCTGTTACTCGTCATAGCATTGGG
ATGTACTTGTAAGCTTTATTCTCTGAGAATGTTTGAAAGAAGATCATTTGAAACACAGTTGTCAAGAGTGGAAGCAGAATTGTTAAGAAG
AGAAGCTCCTCCCTCGTATGGACAATTGATTGCTCAGGGTTTAATTCCACCAGTTGAAGATTTTCCTGTTTGTTCACCTAATCAGGCTTC
TGTTTTGGAAAATCTGAGGCTAGCGGTACGATCTCAGCTTGGATTTACTTCAGTCAGGCTTCCTATGGCAGGCAGATCAAGCAACATTTG
GAACCGTATTTTTAATTTTGCAAGATCACGTCATTCTGGGTCATTGGCTTTGGTCTCAGCAGATGGAGATGAGGTTGTCCCTAGTCAGAG
TACCAGTAGAGAACCTGAGAGAAATCATACTCACAGAAGTTTGTTTTCCGTGGAGTCTGATGATACAGACACAGAAAATGAGAGAAGAGA
TATGGCAGGAGCATCTGGTGGGGTTGCAGCTCCTTTGCCTCAAAAAGTCCCTCCCACAACGGCAGTAGAAGCGACAGTAGGAGCATGTGC
AAGTTCCTCAACTCAGAGTACCCGAGGTGGTCATGCAGATAATGGAAGGGATGTGACAAGTGTGGAACCCCCAAGTGTGAGTCCAGCACG
TCACCAGCTTACAAGTGCACTCAGTCGTATGACTCAGGGGCTACGCTGGGTACGTTTTACATTAGGACGATCAAGTTCCCTAAGTCAGAA
CCAGAGTCCTTTGAGACAACTTGATAATGGGGTAAGTGGAAGAGAAGATGATGATGATGTTGAAATGCTAATTCCAATTTCTGATGGATC
TTCAGACTTTGATGTGAATGACTGCTCCAGACCTCTTCTTGATCTTGCCTCAGATCAAGGACAAGGGCTTAGACAACCATATAATGCAAC
AAATCCTGGAGTAAGGCCAAGTAATCGAGATGGCCCCTGTGAGCGCTGTGGTATTGTCCACACTGCCCAGATACCAGACACTTGCTTAGA
AGTAACACTGAAAAACGAAACGAGTGATGATGAGGCTTTGTTACTTTGTTAGGTACGAATCACATAAGGGAGATTGTATACAAGTTGGAG
CAATATCCATTTATTATTTTGTAACTTTACAGTTAAACTAGTTTTAGTTTAAAAAGAAAAAATGCAGGGTGATTTCTTATTATTATATGT
TAGCCTGCATGGTTAAATTCGACAACTTGTAACTCTATGAACTTAGAGTTTACTATTTTAGCAGCTAAAAATGCATCACATATTCATATT
GTTCAATAATGTCCTTTCATTTGTTTCTGATTGTTTTCATCCTGATACTGTAGTTCACTGTAGAAATGTGGCTGCTGAAACTCATTTGAT
TGTCATTTTTATCTATCCTATGTTAAATGGTTTGTTTTTACAAAATAATACCTTATTTTAATTGAAACGTTTATGCTTTTGCCAACACAT
CTTGTAACTTAATATACTAGATGTTAAGGTTGTTAATGTACAAAAAAAAAACCCTTATACTCACCTGCGTTTTCATTTGTTTGACATTTG
TCTATTATTGGATTTCATTATCATATGAACTTGTCAGTGGGAAACAAACTGTCTAAAAATTTTTCTCTTACGTTTAACATACAATCATGT
GAAATTTAGGCAGAGTTCGATAAATTACTGGCAAAAACAAAACTCTTTTATAAAGATTTTCTAATGTTGACTTTAATACTCTAACATGGT
ACAAACCAAATGGTAAAATCCCAAGTCATTTCTTTTTTCATCTCTATTTAGCAACAGAATTAAGTGGATGAAGATATTCTACTATGCATT
AAATCTTGAACTTTATAAAACATGTACAAAAATTGTACAAGATAAGTTCCACCTGGTAATGTCTTTCCCTAATACAGGGTTGCGCTTGCA
TTGGACCCTAGGGATTTGCACTAAAATTATATCAAGGTCTCAGATGAGCTTAGTGCACAAGCACTATCACTTTAAATACTATTATTTGCT
ACCACAGCAACTATATATTTCCATAGCTTTTGGCTGGGGGCGGGGGACATTTTTATTACAACTTGAAATTGCTTTGCTGGTTTCATATTT
ATTTGTTGTATTTAAAAAATACATTGTTGTAAGAGTGATTTTTTCAATATATTTTATTCCTGGGGGGGATCATGCTACACTCTCAAAAGA
AAATTAAGAAATCATTCAGATCATCCCCCCTTTTTAAGTAGTGTGAATTGCAAAACCCAACATATTTTTTTTACTGTCAGTTGCGGTTTA
TTTATTCTTTAACTGTCTGTTTTAGTAGTTTAATGATTATGAAAAATGTATCTGTGTGTGATTTGCTATTTATTAAATTTTAAGTACTTT
GCTGAATGTCATTTTAAAGCATGTTTGAAGTCTTGTGTATTTGTCTGTGTTAATGCTGTCAGGAGGAACTGACTAAGATGTTTTAATATG

>94430_94430_1_TRPS1-LRP12_TRPS1_chr8_116599228_ENST00000395715_LRP12_chr8_105521302_ENST00000276654_length(amino acids)=914AA_BP=
MPYEVNAGYDFTNMVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSENTDQSDAAELNHKEEHSLHVQDPSSSSKKDLKS
AVLSEKAGFNYESPSKGGNFPSFPHDEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQKMSPKATEETGQA
QSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQD
AELDSKILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSS
TELEQHFLQTHPNKIKASLPSSEVAKPSEKNSNKSIPALQSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCK
FCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETMTKTDKSSSGAKKKDFSSKGAEDNMVTSYNCQF
CDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCH
QCSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSL
LEHFNTVHCQEQDITTANGEEDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNVTWRGA
DILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIYGLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLR

--------------------------------------------------------------
>94430_94430_2_TRPS1-LRP12_TRPS1_chr8_116599228_ENST00000395715_LRP12_chr8_105521302_ENST00000424843_length(transcript)=7164nt_BP=3278nt
AATAGTGTTGGTGTCTTGAAACTGACGTAATGCGCGGAGACTGAGGTCCTGACAAGCGATAACATTTCTGATAAAGACCCGATCTTACTG
CAATCTCTAGCGTCCTCTTTTTTGGTGCTGCTGGTTTCTCCAGACCTCGCGTCCTCTCGATTGCTCTCTCGCCTTCCTATTTCTTTTTTT
TTTTTTTAAACAAAAAACAACACCCCCTCCCCTCTCCCACCCGGCACCGGGCACATCCTTGCTCTATTTCCTTTCTCTTTCTCTCTCTCT
CTCTCTCTCTCTCTTTTTTAATAAGGGTGGGGGAGGGAAAGGGGGGGGAGGCAGGAAAGACCTTTTTCTCTCCCCCCCGCAATAATCCAA
GATCAACTCTGCAAACAACAGAAGACGGTTCATGGCTTTGGCCGCCGCGCCACCATCTTTCGGGCTGCCGAGGGTGTTCTTGACGATTAA
TCAACAGATGTACAGATCAGCTCTCAAAATGTCTTCTGTGTCTTCTGAGCGTCTTCTAAGACAATTGCATTAGCCTCCTGCTAGTTGACT
AATAGAATTAATAATTGTAAAAAGCACTCTAAAGCCACATGCCTTATGAAGTCAATGCTGGGTATGATTTTACAAATATGGTCCGGAAAA
AGAACCCCCCTCTGAGAAACGTTGCAAGTGAAGGCGAGGGCCAGATCCTGGAGCCTATAGGTACAGAAAGCAAGGTATCTGGAAAGAACA
AAGAATTTTCTGCAGATCAGATGTCAGAAAATACGGATCAGAGTGATGCTGCAGAACTAAATCATAAGGAGGAACATAGCTTGCATGTTC
AAGATCCATCTTCTAGCAGTAAGAAGGACTTGAAAAGCGCAGTTCTGAGTGAGAAGGCTGGCTTCAATTATGAAAGCCCCAGTAAGGGAG
GAAACTTTCCCTCCTTTCCGCATGATGAGGTGACAGACAGAAATATGTTGGCTTTCTCATCTCCAGCTGCTGGGGGAGTCTGTGAGCCCT
TGAAGTCTCCGCAAAGAGCAGAGGCAGATGACCCTCAAGATATGGCCTGCACCCCCTCAGGGGACTCACTGGAGACAAAGGAAGATCAGA
AGATGTCACCAAAGGCTACAGAGGAAACAGGGCAAGCACAGAGTGGTCAAGCCAATTGTCAAGGTTTGAGCCCAGTTTCAGTGGCCTCAA
AAAACCCACAAGTGCCTTCAGATGGGGGTGTAAGACTGAATAAATCCAAAACTGACTTACTGGTGAATGACAACCCAGACCCGGCACCTC
TGTCTCCAGAGCTTCAGGACTTTAAATGCAATATCTGTGGATATGGTTACTACGGCAACGACCCCACAGATCTGATTAAGCACTTCCGAA
AGTATCACTTAGGACTGCATAACCGCACCAGGCAAGATGCTGAGCTGGACAGCAAAATCTTGGCCCTTCATAACATGGTGCAGTTCAGCC
ATTCCAAAGACTTCCAGAAGGTCAACCGTTCTGTGTTTTCTGGTGTGCTGCAGGACATCAATTCTTCAAGGCCTGTTTTACTAAATGGGA
CCTATGATGTGCAGGTGACTTCAGGTGGAACATTCATTGGCATTGGACGGAAAACACCAGATTGCCAAGGGAACACCAAGTATTTCCGCT
GTAAATTCTGCAATTTCACTTATATGGGCAACTCATCCACCGAATTAGAACAACATTTTCTTCAGACTCACCCAAACAAAATAAAAGCTT
CTCTCCCCTCCTCTGAGGTTGCAAAACCTTCAGAGAAAAACTCTAACAAGTCCATCCCTGCACTTCAATCCAGTGATTCTGGAGACTTGG
GAAAATGGCAGGACAAGATAACAGTCAAAGCAGGAGATGACACTCCTGTTGGGTACTCAGTGCCCATAAAGCCCCTCGATTCCTCTAGAC
AAAATGGTACAGAGGCCACCAGTTACTACTGGTGTAAATTTTGTAGTTTCAGCTGTGAGTCATCTAGCTCACTTAAACTGCTAGAACATT
ATGGCAAGCAGCACGGAGCAGTGCAGTCAGGCGGCCTTAATCCAGAGTTAAATGATAAGCTTTCCAGGGGCTCTGTCATTAATCAGAATG
ATCTAGCCAAAAGTTCAGAAGGAGAGACAATGACCAAGACAGACAAGAGCTCGAGTGGGGCTAAAAAGAAGGACTTCTCCAGCAAGGGAG
CCGAGGATAATATGGTAACGAGCTATAATTGTCAGTTCTGTGACTTCCGATATTCCAAAAGCCATGGCCCTGATGTAATTGTAGTGGGGC
CACTTCTCCGTCATTATCAACAGCTCCATAACATTCACAAGTGTACCATTAAACACTGTCCATTCTGTCCCAGAGGACTTTGCAGCCCAG
AAAAGCACCTTGGAGAAATTACTTATCCGTTTGCTTGTAGAAAAAGTAATTGTTCCCACTGTGCACTCTTGCTTCTGCACTTGTCTCCTG
GGGCGGCTGGAAGCTCGCGAGTCAAACATCAGTGCCATCAGTGTTCATTCACCACCCCTGACGTAGATGTACTCCTCTTTCACTATGAAA
GTGTGCATGAGTCCCAAGCATCGGATGTCAAACAAGAAGCAAATCACCTGCAAGGATCGGATGGGCAGCAGTCTGTCAAGGAAAGCAAAG
AACACTCATGTACCAAATGTGATTTTATTACCCAAGTGGAAGAAGAGATTTCCCGACACTACAGGAGAGCACACAGCTGCTACAAATGCC
GTCAGTGCAGTTTTACAGCTGCCGATACTCAGTCACTACTGGAGCACTTCAACACTGTTCACTGCCAGGAACAGGACATCACTACAGCCA
ACGGCGAAGAGGACGGTCATGCCATATCCACCATCAAAGAGGAGCCCAAAATTGACTTCAGGGTCTACAATCTGCTAACTCCAGACTCTA
AAATGGGAGAGCCAGTTTCTGAGAGTGTGGTGAAGAGAGAGAAGCTGGAAGAGAAGGACGGGCTCAAAGAGAAAGTTTGGACCGAGAGTT
CCAGTGATGACCTTCGCAATGTGACTTGGAGAGGGGCAGACATCCTGCGGGGGAGTCCGTCATACACCCAAGCAAGCCTGGGGCTGCTGA
CGCCTGTGTCTGGCACCCAAGAGCAGACAAAGACTCTAAGGGATAGTCCCAATGTGGAGGCCGCCCATCTGGCGCGACCTATTTATGGCT
TGGCTGTGGAAACCAAGGGATTCCTGCAGGGGGCGCCAGCTGGCGGAGAGAAGTCTGGGGCCCTCCCCCAGCAGTATCCTGCATCGGGAG
AAAACAAGTCCAAGGATGAATCCCAGTCCCTGTTACGGCTTGTGGAGAGACTCCAGAGCAAATACGAGCACCAAGTGGCATAATCACAAG
CCCAGGCTGGCCTTCTGAATATCCTGCAAAAATCAACTGTAGCTGGTTCATAAGGGCAAACCCAGGCGAAATCATTACTATAAGTTTTCA
GGATTTTGATATTCAAGGATCCAGAAGGTGCAATTTGGACTGGTTGACAATAGAAACATACAAGAATATTGAAAGTTACAGAGCTTGTGG
TTCCACAATTCCACCTCCGTATATCTCTTCACAAGACCACATCTGGATTAGGTTTCATTCGGATGACAACATCTCTAGAAAGGGTTTCAG
ACTGGCATATTTTTCAGGGAAATCTGAGGAACCAAATTGTGCTTGTGATCAGTTTCGTTGTGGTAATGGAAAGTGTATACCAGAAGCCTG
GAAATGTAATAACATGGATGAATGTGGAGATAGTTCCGATGAAGAGATCTGTGCCAAAGAAGCAAATCCTCCAACTGCTGCTGCTTTTCA
ACCCTGTGCTTACAACCAGTTCCAGTGTTTATCCCGTTTTACCAAAGTTTACACTTGCCTCCCCGAATCTTTAAAATGTGATGGGAACAT
TGACTGCCTTGACCTAGGAGATGAGATAGACTGTGATGTGCCAACATGTGGGCAATGGCTAAAATATTTTTATGGTACTTTTAATTCTCC
CAATTATCCAGACTTTTATCCTCCTGGAAGCAATTGCACCTGGTTAATAGACACTGGTGATCACCGTAAAGTCATTTTACGCTTCACTGA
CTTTAAACTTGATGGTACTGGTTATGGTGATTATGTCAAAATATATGATGGATTAGAGGAGAATCCACACAAGCTTTTGCGTGTGTTGAC
AGCTTTTGATTCTCATGCACCTCTTACAGTTGTTTCTTCTTCTGGACAGATAAGGGTACATTTTTGTGCTGATAAAGTGAATGCTGCAAG
GGGATTTAATGCTACTTACCAAGTAGATGGGTTCTGTTTGCCATGGGAAATACCCTGTGGAGGTAACTGGGGGTGTTATACTGAGCAGCA
GCGTTGTGATGGGTATTGGCATTGCCCAAATGGAAGGGATGAAACCAATTGTACCATGTGCCAGAAGGAAGAATTTCCATGTTCCCGAAA
TGGTGTCTGTTATCCTCGTTCTGATCGCTGCAACTACCAGAATCATTGCCCAAATGGCTCAGATGAAAAAAACTGCTTTTTTTGCCAACC
AGGAAATTTCCATTGTAAAAACAATCGTTGTGTGTTTGAAAGTTGGGTGTGTGATTCTCAAGATGACTGTGGTGATGGCAGCGATGAAGA
AAATTGCCCAGTAATCGTGCCTACAAGAGTCATCACTGCTGCCGTCATAGGGAGCCTCATCTGTGGCCTGTTACTCGTCATAGCATTGGG
ATGTACTTGTAAGCTTTATTCTCTGAGAATGTTTGAAAGAAGATCATTTGAAACACAGTTGTCAAGAGTGGAAGCAGAATTGTTAAGAAG
AGAAGCTCCTCCCTCGTATGGACAATTGATTGCTCAGGGTTTAATTCCACCAGTTGAAGATTTTCCTGTTTGTTCACCTAATCAGGCTTC
TGTTTTGGAAAATCTGAGGCTAGCGGTACGATCTCAGCTTGGATTTACTTCAGTCAGGCTTCCTATGGCAGGCAGATCAAGCAACATTTG
GAACCGTATTTTTAATTTTGCAAGATCACGTCATTCTGGGTCATTGGCTTTGGTCTCAGCAGATGGAGATGAGGTTGTCCCTAGTCAGAG
TACCAGTAGAGAACCTGAGAGAAATCATACTCACAGAAGTTTGTTTTCCGTGGAGTCTGATGATACAGACACAGAAAATGAGAGAAGAGA
TATGGCAGGAGCATCTGGTGGGGTTGCAGCTCCTTTGCCTCAAAAAGTCCCTCCCACAACGGCAGTAGAAGCGACAGTAGGAGCATGTGC
AAGTTCCTCAACTCAGAGTACCCGAGGTGGTCATGCAGATAATGGAAGGGATGTGACAAGTGTGGAACCCCCAAGTGTGAGTCCAGCACG
TCACCAGCTTACAAGTGCACTCAGTCGTATGACTCAGGGGCTACGCTGGGTACGTTTTACATTAGGACGATCAAGTTCCCTAAGTCAGAA
CCAGAGTCCTTTGAGACAACTTGATAATGGGGTAAGTGGAAGAGAAGATGATGATGATGTTGAAATGCTAATTCCAATTTCTGATGGATC
TTCAGACTTTGATGTGAATGACTGCTCCAGACCTCTTCTTGATCTTGCCTCAGATCAAGGACAAGGGCTTAGACAACCATATAATGCAAC
AAATCCTGGAGTAAGGCCAAGTAATCGAGATGGCCCCTGTGAGCGCTGTGGTATTGTCCACACTGCCCAGATACCAGACACTTGCTTAGA
AGTAACACTGAAAAACGAAACGAGTGATGATGAGGCTTTGTTACTTTGTTAGGTACGAATCACATAAGGGAGATTGTATACAAGTTGGAG
CAATATCCATTTATTATTTTGTAACTTTACAGTTAAACTAGTTTTAGTTTAAAAAGAAAAAATGCAGGGTGATTTCTTATTATTATATGT
TAGCCTGCATGGTTAAATTCGACAACTTGTAACTCTATGAACTTAGAGTTTACTATTTTAGCAGCTAAAAATGCATCACATATTCATATT
GTTCAATAATGTCCTTTCATTTGTTTCTGATTGTTTTCATCCTGATACTGTAGTTCACTGTAGAAATGTGGCTGCTGAAACTCATTTGAT
TGTCATTTTTATCTATCCTATGTTAAATGGTTTGTTTTTACAAAATAATACCTTATTTTAATTGAAACGTTTATGCTTTTGCCAACACAT
CTTGTAACTTAATATACTAGATGTTAAGGTTGTTAATGTACAAAAAAAAAACCCTTATACTCACCTGCGTTTTCATTTGTTTGACATTTG
TCTATTATTGGATTTCATTATCATATGAACTTGTCAGTGGGAAACAAACTGTCTAAAAATTTTTCTCTTACGTTTAACATACAATCATGT
GAAATTTAGGCAGAGTTCGATAAATTACTGGCAAAAACAAAACTCTTTTATAAAGATTTTCTAATGTTGACTTTAATACTCTAACATGGT
ACAAACCAAATGGTAAAATCCCAAGTCATTTCTTTTTTCATCTCTATTTAGCAACAGAATTAAGTGGATGAAGATATTCTACTATGCATT
AAATCTTGAACTTTATAAAACATGTACAAAAATTGTACAAGATAAGTTCCACCTGGTAATGTCTTTCCCTAATACAGGGTTGCGCTTGCA
TTGGACCCTAGGGATTTGCACTAAAATTATATCAAGGTCTCAGATGAGCTTAGTGCACAAGCACTATCACTTTAAATACTATTATTTGCT
ACCACAGCAACTATATATTTCCATAGCTTTTGGCTGGGGGCGGGGGACATTTTTATTACAACTTGAAATTGCTTTGCTGGTTTCATATTT
ATTTGTTGTATTTAAAAAATACATTGTTGTAAGAGTGATTTTTTCAATATATTTTATTCCTGGGGGGGATCATGCTACACTCTCAAAAGA
AAATTAAGAAATCATTCAGATCATCCCCCCTTTTTAAGTAGTGTGAATTGCAAAACCCAACATATTTTTTTTACTGTCAGTTGCGGTTTA
TTTATTCTTTAACTGTCTGTTTTAGTAGTTTAATGATTATGAAAAATGTATCTGTGTGTGATTTGCTATTTATTAAATTTTAAGTACTTT
GCTGAATGTCATTTTAAAGCATGTTTGAAGTCTTGTGTATTTGTCTGTGTTAATGCTGTCAGGAGGAACTGACTAAGATGTTTTAATATG

>94430_94430_2_TRPS1-LRP12_TRPS1_chr8_116599228_ENST00000395715_LRP12_chr8_105521302_ENST00000424843_length(amino acids)=914AA_BP=
MPYEVNAGYDFTNMVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSENTDQSDAAELNHKEEHSLHVQDPSSSSKKDLKS
AVLSEKAGFNYESPSKGGNFPSFPHDEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQKMSPKATEETGQA
QSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQD
AELDSKILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSS
TELEQHFLQTHPNKIKASLPSSEVAKPSEKNSNKSIPALQSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCK
FCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETMTKTDKSSSGAKKKDFSSKGAEDNMVTSYNCQF
CDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCH
QCSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSL
LEHFNTVHCQEQDITTANGEEDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNVTWRGA
DILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIYGLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRPS1-LRP12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRPS1-LRP12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRPS1-LRP12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource