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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TRPS1-RAD21 (FusionGDB2 ID:94437)

Fusion Gene Summary for TRPS1-RAD21

Fusion gene summary

Fusion gene information	Fusion gene name: TRPS1-RAD21
	Fusion gene ID: 94437
		Hgene	Tgene
	Gene symbol	TRPS1	RAD21
	Gene ID	7227	5885
	Gene name	transcriptional repressor GATA binding 1	RAD21 cohesin complex component
	Synonyms	GC79\|LGCR	CDLS4\|HR21\|HRAD21\|MCD1\|MGS\|NXP1\|SCC1\|hHR21
	Cytomap	8q23.3	8q24.11
	Type of gene	protein-coding	protein-coding
	Description	zinc finger transcription factor Trps1tricho-rhino-phalangeal syndrome type I proteintrichorhinophalangeal syndrome Izinc finger protein GC79	double-strand-break repair protein rad21 homologNXP-1RAD21 homologSCC1 homologkleisinnuclear matrix protein 1protein involved in DNA double-strand break repairsister chromatid cohesion 1
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000220888, ENST00000395715, ENST00000519076, ENST00000519674, ENST00000520276,	ENST00000523547, ENST00000517749, ENST00000518055, ENST00000523986, ENST00000297338,
Fusion gene scores	* DoF score	27 X 17 X 6=2754	10 X 11 X 6=660
	# samples	31	12
	** MAII score	log2(31/2754*10)=-3.15118843886073 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/660*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TRPS1 [Title/Abstract] AND RAD21 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TRPS1(116599228)-RAD21(117869712), # samples:1
Anticipated loss of major functional domain due to fusion event.	TRPS1-RAD21 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TRPS1-RAD21 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. TRPS1-RAD21 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TRPS1	GO:0000122	negative regulation of transcription by RNA polymerase II	12885770\|21673316
Tgene	RAD21	GO:0006357	regulation of transcription by RNA polymerase II	19468298

Fusion gene breakpoints across TRPS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD21 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-E9-A1RB-11A	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-

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Fusion Gene ORF analysis for TRPS1-RAD21

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000220888	ENST00000523547	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-5UTR	ENST00000395715	ENST00000523547	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-5UTR	ENST00000519076	ENST00000523547	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-5UTR	ENST00000519674	ENST00000523547	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-5UTR	ENST00000520276	ENST00000523547	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000220888	ENST00000517749	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000220888	ENST00000518055	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000220888	ENST00000523986	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000395715	ENST00000517749	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000395715	ENST00000518055	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000395715	ENST00000523986	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000519076	ENST00000517749	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000519076	ENST00000518055	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000519076	ENST00000523986	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000519674	ENST00000517749	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000519674	ENST00000518055	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000519674	ENST00000523986	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000520276	ENST00000517749	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000520276	ENST00000518055	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
5CDS-intron	ENST00000520276	ENST00000523986	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
Frame-shift	ENST00000220888	ENST00000297338	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
Frame-shift	ENST00000519076	ENST00000297338	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
Frame-shift	ENST00000519674	ENST00000297338	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
Frame-shift	ENST00000520276	ENST00000297338	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-
In-frame	ENST00000395715	ENST00000297338	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000395715

TRPS1

chr8

116599228

ENST00000297338

RAD21

chr8

117869712

6258

3278

578

3307

909

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000395715	ENST00000297338	TRPS1	chr8	116599228	-	RAD21	chr8	117869712	-	0.000192916	0.99980706

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Fusion Genomic Features for TRPS1-RAD21

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRPS1-RAD21

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:116599228/chr8:117869712)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000220888

222_247

887

1282.0

Zinc finger

C2H2-type 1%3B atypical

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000220888

333_358

887

1282.0

Zinc finger

C2H2-type 2%3B atypical

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000220888

614_637

887

1282.0

Zinc finger

C2H2-type 3%3B atypical

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000220888

666_689

887

1282.0

Zinc finger

C2H2-type 4

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000220888

692_715

887

1282.0

Zinc finger

C2H2-type 5

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000395715

222_247

900

1295.0

Zinc finger

C2H2-type 1%3B atypical

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000395715

333_358

900

1295.0

Zinc finger

C2H2-type 2%3B atypical

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000395715

614_637

900

1295.0

Zinc finger

C2H2-type 3%3B atypical

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000395715

666_689

900

1295.0

Zinc finger

C2H2-type 4

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000395715

692_715

900

1295.0

Zinc finger

C2H2-type 5

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000520276

222_247

891

1286.0

Zinc finger

C2H2-type 1%3B atypical

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000520276

333_358

891

1286.0

Zinc finger

C2H2-type 2%3B atypical

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000520276

614_637

891

1286.0

Zinc finger

C2H2-type 3%3B atypical

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000520276

666_689

891

1286.0

Zinc finger

C2H2-type 4

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000520276

692_715

891

1286.0

Zinc finger

C2H2-type 5

Tgene

RAD21

chr8:116599228

chr8:117869712

ENST00000297338

469_510

160

632.0

Compositional bias

Note=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000220888

1163_1281

887

1282.0

Region

Transcriptional repressor domain

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000395715

1163_1281

900

1295.0

Region

Transcriptional repressor domain

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000520276

1163_1281

891

1286.0

Region

Transcriptional repressor domain

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000220888

1215_1237

887

1282.0

Zinc finger

C2H2-type 6

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000220888

1243_1267

887

1282.0

Zinc finger

C2H2-type 7

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000220888

896_920

887

1282.0

Zinc finger

GATA-type

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000395715

1215_1237

900

1295.0

Zinc finger

C2H2-type 6

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000395715

1243_1267

900

1295.0

Zinc finger

C2H2-type 7

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000395715

896_920

900

1295.0

Zinc finger

GATA-type

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000520276

1215_1237

891

1286.0

Zinc finger

C2H2-type 6

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000520276

1243_1267

891

1286.0

Zinc finger

C2H2-type 7

Hgene

TRPS1

chr8:116599228

chr8:117869712

ENST00000520276

896_920

891

1286.0

Zinc finger

GATA-type

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Fusion Gene Sequence for TRPS1-RAD21

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>94437_94437_1_TRPS1-RAD21_TRPS1_chr8_116599228_ENST00000395715_RAD21_chr8_117869712_ENST00000297338_length(transcript)=6258nt_BP=3278nt
AATAGTGTTGGTGTCTTGAAACTGACGTAATGCGCGGAGACTGAGGTCCTGACAAGCGATAACATTTCTGATAAAGACCCGATCTTACTG
CAATCTCTAGCGTCCTCTTTTTTGGTGCTGCTGGTTTCTCCAGACCTCGCGTCCTCTCGATTGCTCTCTCGCCTTCCTATTTCTTTTTTT
TTTTTTTAAACAAAAAACAACACCCCCTCCCCTCTCCCACCCGGCACCGGGCACATCCTTGCTCTATTTCCTTTCTCTTTCTCTCTCTCT
CTCTCTCTCTCTCTTTTTTAATAAGGGTGGGGGAGGGAAAGGGGGGGGAGGCAGGAAAGACCTTTTTCTCTCCCCCCCGCAATAATCCAA
GATCAACTCTGCAAACAACAGAAGACGGTTCATGGCTTTGGCCGCCGCGCCACCATCTTTCGGGCTGCCGAGGGTGTTCTTGACGATTAA
TCAACAGATGTACAGATCAGCTCTCAAAATGTCTTCTGTGTCTTCTGAGCGTCTTCTAAGACAATTGCATTAGCCTCCTGCTAGTTGACT
AATAGAATTAATAATTGTAAAAAGCACTCTAAAGCCACATGCCTTATGAAGTCAATGCTGGGTATGATTTTACAAATATGGTCCGGAAAA
AGAACCCCCCTCTGAGAAACGTTGCAAGTGAAGGCGAGGGCCAGATCCTGGAGCCTATAGGTACAGAAAGCAAGGTATCTGGAAAGAACA
AAGAATTTTCTGCAGATCAGATGTCAGAAAATACGGATCAGAGTGATGCTGCAGAACTAAATCATAAGGAGGAACATAGCTTGCATGTTC
AAGATCCATCTTCTAGCAGTAAGAAGGACTTGAAAAGCGCAGTTCTGAGTGAGAAGGCTGGCTTCAATTATGAAAGCCCCAGTAAGGGAG
GAAACTTTCCCTCCTTTCCGCATGATGAGGTGACAGACAGAAATATGTTGGCTTTCTCATCTCCAGCTGCTGGGGGAGTCTGTGAGCCCT
TGAAGTCTCCGCAAAGAGCAGAGGCAGATGACCCTCAAGATATGGCCTGCACCCCCTCAGGGGACTCACTGGAGACAAAGGAAGATCAGA
AGATGTCACCAAAGGCTACAGAGGAAACAGGGCAAGCACAGAGTGGTCAAGCCAATTGTCAAGGTTTGAGCCCAGTTTCAGTGGCCTCAA
AAAACCCACAAGTGCCTTCAGATGGGGGTGTAAGACTGAATAAATCCAAAACTGACTTACTGGTGAATGACAACCCAGACCCGGCACCTC
TGTCTCCAGAGCTTCAGGACTTTAAATGCAATATCTGTGGATATGGTTACTACGGCAACGACCCCACAGATCTGATTAAGCACTTCCGAA
AGTATCACTTAGGACTGCATAACCGCACCAGGCAAGATGCTGAGCTGGACAGCAAAATCTTGGCCCTTCATAACATGGTGCAGTTCAGCC
ATTCCAAAGACTTCCAGAAGGTCAACCGTTCTGTGTTTTCTGGTGTGCTGCAGGACATCAATTCTTCAAGGCCTGTTTTACTAAATGGGA
CCTATGATGTGCAGGTGACTTCAGGTGGAACATTCATTGGCATTGGACGGAAAACACCAGATTGCCAAGGGAACACCAAGTATTTCCGCT
GTAAATTCTGCAATTTCACTTATATGGGCAACTCATCCACCGAATTAGAACAACATTTTCTTCAGACTCACCCAAACAAAATAAAAGCTT
CTCTCCCCTCCTCTGAGGTTGCAAAACCTTCAGAGAAAAACTCTAACAAGTCCATCCCTGCACTTCAATCCAGTGATTCTGGAGACTTGG
GAAAATGGCAGGACAAGATAACAGTCAAAGCAGGAGATGACACTCCTGTTGGGTACTCAGTGCCCATAAAGCCCCTCGATTCCTCTAGAC
AAAATGGTACAGAGGCCACCAGTTACTACTGGTGTAAATTTTGTAGTTTCAGCTGTGAGTCATCTAGCTCACTTAAACTGCTAGAACATT
ATGGCAAGCAGCACGGAGCAGTGCAGTCAGGCGGCCTTAATCCAGAGTTAAATGATAAGCTTTCCAGGGGCTCTGTCATTAATCAGAATG
ATCTAGCCAAAAGTTCAGAAGGAGAGACAATGACCAAGACAGACAAGAGCTCGAGTGGGGCTAAAAAGAAGGACTTCTCCAGCAAGGGAG
CCGAGGATAATATGGTAACGAGCTATAATTGTCAGTTCTGTGACTTCCGATATTCCAAAAGCCATGGCCCTGATGTAATTGTAGTGGGGC
CACTTCTCCGTCATTATCAACAGCTCCATAACATTCACAAGTGTACCATTAAACACTGTCCATTCTGTCCCAGAGGACTTTGCAGCCCAG
AAAAGCACCTTGGAGAAATTACTTATCCGTTTGCTTGTAGAAAAAGTAATTGTTCCCACTGTGCACTCTTGCTTCTGCACTTGTCTCCTG
GGGCGGCTGGAAGCTCGCGAGTCAAACATCAGTGCCATCAGTGTTCATTCACCACCCCTGACGTAGATGTACTCCTCTTTCACTATGAAA
GTGTGCATGAGTCCCAAGCATCGGATGTCAAACAAGAAGCAAATCACCTGCAAGGATCGGATGGGCAGCAGTCTGTCAAGGAAAGCAAAG
AACACTCATGTACCAAATGTGATTTTATTACCCAAGTGGAAGAAGAGATTTCCCGACACTACAGGAGAGCACACAGCTGCTACAAATGCC
GTCAGTGCAGTTTTACAGCTGCCGATACTCAGTCACTACTGGAGCACTTCAACACTGTTCACTGCCAGGAACAGGACATCACTACAGCCA
ACGGCGAAGAGGACGGTCATGCCATATCCACCATCAAAGAGGAGCCCAAAATTGACTTCAGGGTCTACAATCTGCTAACTCCAGACTCTA
AAATGGGAGAGCCAGTTTCTGAGAGTGTGGTGAAGAGAGAGAAGCTGGAAGAGAAGGACGGGCTCAAAGAGAAAGTTTGGACCGAGAGTT
CCAGTGATGACCTTCGCAATGTGACTTGGAGAGGGGCAGACATCCTGCGGGGGAGTCCGTCATACACCCAAGCAAGCCTGGGGCTGCTGA
CGCCTGTGTCTGGCACCCAAGAGCAGACAAAGACTCTAAGGGATAGTCCCAATGTGGAGGCCGCCCATCTGGCGCGACCTATTTATGGCT
TGGCTGTGGAAACCAAGGGATTCCTGCAGGGGGCGCCAGCTGGCGGAGAGAAGTCTGGGGCCCTCCCCCAGCAGTATCCTGCATCGGGAG
AAAACAAGTCCAAGGATGAATCCCAGTCCCTGTTACGGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGCAGTGCTTTTGA
GGATGACGACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAGAAAATTAACCA
TTTAGAATATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATTAGTAATAATGA
TGGCGGTATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATGGATGAGGATGA
TAATGTATCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACAACACTTGTTCC
AAATGAGGAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTAATTGTTGACAG
TGTCAAAGAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCACCGCCCACCAA
GAAATTGATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGACTACTGAAGCT
CTTTACACGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGATGAATTCCTCAA
AGAATTTGAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATTATTGAAGAGCC
AAGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAGGGAGTTAAGCG
AAAAGCTGGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTTCCCCCAGAAGA
ACCTCCAAATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAAGATGATGAAGA
GGAAGAGGATGAAGATGCATCAGGGGGCGATCAAGATCAGGAAGAAAGAAGATGGAACAAAAGGACTCAGCAGATGCTTCATGGTCTTCA
GCGTGCTCTTGCTAAAACTGGAGCTGAATCTATCAGTTTGCTTGAGTTATGTCGAAATACGAACAGAAAACAAGCTGCCGCAAAGTTCTA
CAGCTTCTTGGTTCTTAAAAAGCAGCAAGCTATTGAGCTGACACAGGAAGAACCGTACAGTGACATCATCGCAACACCTGGACCAAGGTT
CCATATTATATAAGGAGCTAGAAGCATTATAGCTAGTGTTTGATTCACTAGTGCTTACAAATTGCCCCCATGTGTAGGGGACACAGAACC
CTTTGAGAAAACTTAGATTTTTGTCTGTACAAAGTCTTTGCCTTTTTCCTTCTTCATTTTTTTCCAGTACATTAAATTTGTCAATTTCAT
CTTTGAGGGAAACTGATTAGATGGGTTGTGTTTGTGTTCTGATGGAGAAAACAGCACCCCAAGGACTCAGAAGATGATTTTAACAGTTCA
GAACAGATGTGTGCAATATTGGTGCATGTAATAATGTTGAGTGGCAGTCAAAAGTCATGATTTTTATCTTAGTTCTTCATTACTGCATTG
AAAAGGAAAACCTGTCTGAGAAAATGCCTGACAGTTTAATTTAAAACTATGGTGTAAGTCTTTGACAAGAAAAAAAAACAAACAAACACT
TCTTTCCATCAGTAACACTGGCAATCTTCCTGTTAACCACTCTCCTTAGGGATGGTATCTGAAACAACAATGGTCACCCTCTTGAGATTC
GTTTTAAGTGTAATTCCATAATGAGCAGAGGTGTACGCGAAATTGTGTTATGACTGATAGCCTTCAGCTACAAAAAGATAGGACTGACCT
GGTTTAAAGTGTTCTATTTTGTAAATCATTCCATTTGAGTCTTTCTGATGAACTTGGCTATACTGAAATCTGTTATTTTAGTGAGGCTCC
AAAATGAGCAAAGCTAGGCCTGATTAGAGTAGAGTGACTATTAAAAAACATAACTTTCTAGGAGCTATAAATCAAAGTTTTAAAAAGATG
TTTGGATATATTTGAGTATTCCGATCATGAAAACAGAAATTGCCCTGCCTACTACAAGGACAGACTGATGGGAAATTATGCACCTGGTCA
ACTTAGCTTTTAAGCAGACGATGCTGTAAAAACTAACGGCTTCTCTGATATTTATTGTAAGTTTTAGTACTGATCTCCTTTTCCAGTGCT
GCACACTCCTGGTTTGGAACTTTAATAGCGTTGCAACGAAATCCTATATCCAGTTTCCTGTAATTTAATTGAAGAAAAATACATCCAAAT
AAAGACTTTATTATTAACAGACCAGATAGCATCAGAAATCATGTGACTGTTATGATTATCAGAATGTCTTAACTTTTTAGGGCAAAGTTA
ACACTGAAAGTTCTAGCTTAAGTGTTGAAACTTTTGTGGGAAAAAAAAATCACTTTTGAAACTCAGACTTCAGTGTATACCCAATAATTT
AAAATTATGTGAAATGTTTTAAATTTGTGAACTCGTAATTACTGTTTTAATGATTCAGTTTCTTCAGAGTGGTAATTGTATAAAATTGCT
ATTGCAGCTTTACATTCAATATGATGTGCCTGTAAACCAAGGAGTTTTCCCCGTTTGTAAAAAGACATTGTAGATAATTGAATGTTTGAT
TTTAGAAAGGTCATTAGTTTCTTGTTACACATTTTGTTAGTCTGGTTTTTGTTGCTTATCGGGTTTAATATTGTTCTTGAAAATAGTTGA

>94437_94437_1_TRPS1-RAD21_TRPS1_chr8_116599228_ENST00000395715_RAD21_chr8_117869712_ENST00000297338_length(amino acids)=909AA_BP=
MPYEVNAGYDFTNMVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSENTDQSDAAELNHKEEHSLHVQDPSSSSKKDLKS
AVLSEKAGFNYESPSKGGNFPSFPHDEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQKMSPKATEETGQA
QSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQD
AELDSKILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSS
TELEQHFLQTHPNKIKASLPSSEVAKPSEKNSNKSIPALQSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCK
FCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETMTKTDKSSSGAKKKDFSSKGAEDNMVTSYNCQF
CDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCH
QCSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSL
LEHFNTVHCQEQDITTANGEEDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNVTWRGA
DILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIYGLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLR

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Fusion Gene PPI Analysis for TRPS1-RAD21

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	RAD21	chr8:116599228	chr8:117869712	ENST00000297338		4	14	362_403	160.33333333333334	632.0	STAG1
Tgene	RAD21	chr8:116599228	chr8:117869712	ENST00000297338		4	14	287_403	160.33333333333334	632.0	WAPL and PDS5B

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TRPS1-RAD21

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TRPS1-RAD21

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source