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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TRPV6-FOXN3 (FusionGDB2 ID:94452)

Fusion Gene Summary for TRPV6-FOXN3

Fusion gene summary

Fusion gene information	Fusion gene name: TRPV6-FOXN3
	Fusion gene ID: 94452
		Hgene	Tgene
	Gene symbol	TRPV6	FOXN3
	Gene ID	55503	1112
	Gene name	transient receptor potential cation channel subfamily V member 6	forkhead box N3
	Synonyms	ABP/ZF\|CAT1\|CATL\|ECAC2\|HRPTTN\|HSA277909\|LP6728\|ZFAB	C14orf116\|CHES1\|PRO1635
	Cytomap	7q34	14q31.3-q32.11
	Type of gene	protein-coding	protein-coding
	Description	transient receptor potential cation channel subfamily V member 6Alu-binding protein with zinc finger domaincalcium transport protein 1calcium transporter-like proteinepithelial apical membrane calcium transporter/channel CaT1epithelial calcium channe	forkhead box protein N3checkpoint suppressor 1
	Modification date	20200313	20200313
	UniProtAcc	.	O00409
	Ensembl transtripts involved in fusion gene	ENST00000359396,	ENST00000555658, ENST00000261302, ENST00000345097, ENST00000555353, ENST00000557258,
Fusion gene scores	* DoF score	3 X 3 X 3=27	19 X 14 X 9=2394
	# samples	3	20
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(20/2394*10)=-3.58135124716878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TRPV6 [Title/Abstract] AND FOXN3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TRPV6(142583133)-FOXN3(89817152), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TRPV6	GO:0006816	calcium ion transport	23612980
Hgene	TRPV6	GO:0070588	calcium ion transmembrane transport	11097838
Hgene	TRPV6	GO:0098703	calcium ion import across plasma membrane	11097838
Tgene	FOXN3	GO:0045892	negative regulation of transcription, DNA-templated	16102918

Fusion gene breakpoints across TRPV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FOXN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-EJ-7785-11A	TRPV6	chr7	142583133	-	FOXN3	chr14	89817152	-

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Fusion Gene ORF analysis for TRPV6-FOXN3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000359396	ENST00000555658	TRPV6	chr7	142583133	-	FOXN3	chr14	89817152	-
In-frame	ENST00000359396	ENST00000261302	TRPV6	chr7	142583133	-	FOXN3	chr14	89817152	-
In-frame	ENST00000359396	ENST00000345097	TRPV6	chr7	142583133	-	FOXN3	chr14	89817152	-
In-frame	ENST00000359396	ENST00000555353	TRPV6	chr7	142583133	-	FOXN3	chr14	89817152	-
In-frame	ENST00000359396	ENST00000557258	TRPV6	chr7	142583133	-	FOXN3	chr14	89817152	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000359396	TRPV6	chr7	142583133	-	ENST00000345097	FOXN3	chr14	89817152	-	7546	374	392	1303	303
ENST00000359396	TRPV6	chr7	142583133	-	ENST00000261302	FOXN3	chr14	89817152	-	7533	374	392	1303	303
ENST00000359396	TRPV6	chr7	142583133	-	ENST00000557258	FOXN3	chr14	89817152	-	2267	374	392	1237	281
ENST00000359396	TRPV6	chr7	142583133	-	ENST00000555353	FOXN3	chr14	89817152	-	1290	374	392	1237	281

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000359396	ENST00000345097	TRPV6	chr7	142583133	-	FOXN3	chr14	89817152	-	0.000646115	0.9993538
ENST00000359396	ENST00000261302	TRPV6	chr7	142583133	-	FOXN3	chr14	89817152	-	0.000552486	0.9994475
ENST00000359396	ENST00000557258	TRPV6	chr7	142583133	-	FOXN3	chr14	89817152	-	0.012769932	0.98723
ENST00000359396	ENST00000555353	TRPV6	chr7	142583133	-	FOXN3	chr14	89817152	-	0.013687663	0.9863123

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Fusion Genomic Features for TRPV6-FOXN3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRPV6-FOXN3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:142583133/chr14:89817152)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FOXN3 O00409
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269\|PubMed:16102918}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

566_585

726.0

Intramembrane

Pore-forming

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

581_585

726.0

Motif

Selectivity filter

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

118_147

726.0

Repeat

Note=ANK 2

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

156_185

726.0

Repeat

Note=ANK 3

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

202_231

726.0

Repeat

Note=ANK 4

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

235_277

726.0

Repeat

Note=ANK 5

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

279_308

726.0

Repeat

Note=ANK 5

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

84_114

726.0

Repeat

Note=ANK 1

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

1_367

726.0

Topological domain

Cytoplasmic

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

389_425

726.0

Topological domain

Extracellular

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

449_463

726.0

Topological domain

Cytoplasmic

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

484_489

726.0

Topological domain

Extracellular

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

510_529

726.0

Topological domain

Cytoplasmic

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

553_565

726.0

Topological domain

Extracellular

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

586_596

726.0

Topological domain

Extracellular

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

618_765

726.0

Topological domain

Cytoplasmic

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

368_388

726.0

Transmembrane

Helical

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

426_448

726.0

Transmembrane

Helical

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

464_483

726.0

Transmembrane

Helical

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

490_509

726.0

Transmembrane

Helical

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

530_552

726.0

Transmembrane

Helical

Hgene

TRPV6

chr7:142583133

chr14:89817152

ENST00000359396

597_617

726.0

Transmembrane

Helical

Tgene

FOXN3

chr7:142583133

chr14:89817152

ENST00000261302

113_204

181

491.0

DNA binding

Fork-head

Tgene

FOXN3

chr7:142583133

chr14:89817152

ENST00000345097

113_204

181

491.0

DNA binding

Fork-head

Tgene

FOXN3

chr7:142583133

chr14:89817152

ENST00000555353

113_204

181

469.0

DNA binding

Fork-head

Tgene

FOXN3

chr7:142583133

chr14:89817152

ENST00000557258

113_204

181

469.0

DNA binding

Fork-head

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Fusion Gene Sequence for TRPV6-FOXN3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>94452_94452_1_TRPV6-FOXN3_TRPV6_chr7_142583133_ENST00000359396_FOXN3_chr14_89817152_ENST00000261302_length(transcript)=7533nt_BP=374nt
AGACAGGCCAGCCCTGCAGAGTCCTGGCTGGCTCTGCCAAGTGTAACAAACTCACAGCCCTCTCCAAACTGGCTGGGGCTGCTGGGAGAC
TCCCAAGGAACTCGTCAGGAAGGCAGGAGACAGGAGACGGGACCTCTACAGGGAGACGGTGGGCCGGCCCTTGGGGGGGCTGATGTGTCC
CCAAGGCTGAGTCCCGTCAGGGTCTGGCCTCGGCCTCAGGCCCCCAAGGAGCCGGCCCTACACCCCATGGGTTTGTCACTGCCCAAGGAG
AAAGGGCTAATTCTCTGCCTATGGAGCAAGTTCTGCAGATGGTTCCAGAGACGGGAGTCCTGGGCCCAGAGCCGAGATGAGCAGAACCTG
CTGCAGCAGAAGAGAGTATTGGGAAAGGGTCGTTGTGGTGCATAGACCCAGAGTATAGACAAAATCTAATTCAGGCTTTGAAAAAGACAC
CTTATCACCCACACCCACACGTGTTCAATACACCTCCCACCTGTCCTCAGGCATATCAAAGCACATCAGGTCCACCCATCTGGCCGGGCA
GTACCTTCTTCAAGAGAAATGGAGCCCTTCTCCAAGATCCTGACATTGATGCTGCCAGTGCCATGATGCTTTTGAATACTCCCCCTGAGA
TACAAGCAGGTTTTCCTCCAGGAGTGATCCAAAATGGAGCGCGGGTCCTGAGCCGAGGGCTGTTTCCTGGCGTGCGGCCGCTGCCAATCA
CTCCCATTGGGGTGACAGCGGCCATGAGGAATGGCATCACCAGCTGCCGGATGCGGACTGAGAGTGAGCCATCTTGTGGCTCCCCAGTGG
TCAGCGGAGACCCCAAGGAGGATCACAACTACAGCAGTGCCAAGTCCTCCAACGCCCGGAGCACCTCGCCCACCAGCGACTCCATCTCCT
CCTCCTCCTCCTCAGCCGACGACCACTATGAGTTTGCCACCAAGGGGAGCCAGGAGGGCAGCGAGGGCAGCGAGGGGAGCTTCCGGAGCC
ACGAGAGCCCCAGCGACACGGAAGAGGACGACAGGAAGCACAGCCAGAAGGAGCCCAAGGATTCTCTGGGGGACAGCGGGTACGCATCCC
AGCACAAGAAGCGCCAGCACTTCGCCAAGGCCAGGAAGGTCCCCAGCGACACACTGCCCCTCAAAAAGAGACGCACCGAAAAGCCCCCCG
AGAGCGATGATGAGGAGATGAAAGAAGCGGCAGGGTCCCTCCTGCACTTAGCAGGGATCCGGTCCTGTTTGAATAACATCACCAATCGGA
CGGCAAAGGGGCAGAAAGAGCAAAAGGAAACCACAAAAAATTAAAAACAAGTCACTGATTTGTTTTGAACTTACGACCATTTGGTTTCAG
CATGTCAGGAGATTTCTAATGATTTGTGGCAATATCAGCAATTTTTTTTCTTTTTTCTTGTTTTTGGTTTGGTTTTCTTTCTTTTCTTTT
CCTTTTATTTTGTTTTAATTTGCCCCCTCTTCTTTGTTTTGGACCCTTAAGAATTTTATTTTTAAAGGAGATTGAAGCCATAGAACTCAT
ATTGACACTCAGCTGTTTTACAAAAGCTTTTCATTATCTGAAGACAAAACCGAAAAAGCCAAAATTACCATTGCTTCCTCCAGCTTGTCA
GAAACCTGTGGCTGAATCCGCAGGGATGTCAACGTCAATATCACAGGAACACACATTCGGCACCTAGAAGGCACGTGGGCAAAGTAATCA
TCGTTCAGGCCCAACCCTTAGGTTTAAAAAGTCAGGTTGTCCATCCCATTGGGTTCACTGAGTGAAGGCACATAAAGCAATTGAGGAGGA
GGAGGAACCCCTCGTCCCCCTAGGAGCAGACCCAAGCTTGTGGCACCAGGCATCTGATGGTGCCAGGAAAGCCACTGGAATTGTCACACG
GCGAGCACAGAGGGCCGGCCACCAGTCCTCGATGCTTCTGAACCCTGAAGCCCGATGACATCTTACGAGGTGGACGTTGGACTGTTCATG
CGCATCGGGTGTCAGTGACTCATGGAGAAGAAATGGGGTAAATTTTTAGTGATGTTGCTAATCATTGAATTCTGTTCTCTATTAAATTAA
GAAAATGTTCCAAAAGCCATAAGCCTGAAGATTGGCCCTGTGCACGCACGCACACACACACACACACACACACACACACACACACACACA
CGAAGGAGAGAGAGAGAAAACTGATGGGGAAAACAAGCTGTGTCTTCTTAACTGCCCAAGTGAAAAGCAACCAAGTCCAGGAAATTACAA
TAGCTGTTAAGGAAAGGAAATAATGGTACAGATCTTTTTCTGTCTATCAAAACTATTTGATCCAAGTGAAAAAAAAAAAAAAACTAGAAA
GCTACGGAACCTGCCATTAGTATTGTGGTGTATTTTTAAGATTAAAGGTACACTGATGGACAAAAAAAAAAAGTAAAACATGGCAAAAAA
TAAAATAACTCCTATACTGCCCTCAAAATGGAGTTTGCAATTAATATCAGGATTTATCTTTGCAAAAATCAGTGATTTCCACATTCAGCC
AGTATAGCCAGCAGAAATTTCTGATCCACAATGCATGGATTCCTTTGAAGAAAAAAAAGAAAAAGAGAAAAAAATCACAAAAACAAACTT
TTTTTATTCAAAAGTAACAAAGTTCTTGTAAGGTAAATAATGTATTTAGCATGAAGCATGAATTATTTTCATATAAATATAGAAAATAGA
GAAAAGGCTATGCCTGTAATTTTTAAGCCCTTAGGCTTAGAGTTTCTTTTGGTTTTCTTCTTTTTTCTTTCCTTTTCTTTGCTTTCTTTT
TTTCCTTTTTGTTTTTGTTTTTGTTTTTTGTTTTTGTTTTTTTTTCGGGTTATTTTGTTTTGGTTTTTTGAAGCAGGTGTTTAAGGTTTA
ACCTTCTTCAGGGACAAATTCTGACTGTTGGGGAACTTACTCTGCAATATAAAAATATCTTCATGCTCTGGTAGGGCTTGGATGGTTGAA
CTCTGTACTGCCTTGTGTGCACTTCAGCCCCGACCCCCTCTGATTCTCTGTTGAAAAGTGTGTCCTTTCTCTCTGTCTGTACATGTTTAA
CATGACGCAATAATTTGAGGGCAAACTTAGTAGTGAGTGTGTATGATAGAATCAAGAGAATTATGGGACGCTTACTTGAGAAAATCATTA
CCATGATTTGGTTCTAGGAAAAAGGCAGTGAATAATTATGCAAATTAGCCAGAAGAAGGGGAACCGTGCTAATGGGCCTTATTGGGTGAG
GGGACGAGATGGGGTTCATGTGAAGGAGGAAGCGATGCCGAGGTAGGAAAGGCCAGCCCCAGACATCCTATCGCCACAATGCCATGTCGC
AATAGGAAGCAGGGGCCGGCCATCGCTACCTTCAGCACACTGACCAACCTGGAATTAAGACCACCTAGATTGCGAGAGCTGAATTTAGAA
ACCAGACAACGTCATGCAGCCCAGAAACTCCTGTTGTTACCTTTGCCTAAGAAATTTTCTTTAATGGCGGGGGCGGGGGGCGGGGGTACA
AAGAGAAATCTCTAAAAGAATATGATCTTCCATCCAAGTGGAGGGAAACTTTAAAACAAAAACACCCAGTACTGTGGCTCAGGATATGAT
GCGTGAGGAGAGGGAGGGAACAGAGATGACCTTAACTTTTAAAAAAGGGACTGCTGTGGGCCAAAGCCAAGCCCATCTGCCAGGACGAGG
TAATGTCAGAGCTCCATCAGCCCGGACAGTGGGAACTAACTGGTGCATTCCCCACACTTACCTTCCGGTGGGTTGCTGATGAGAGAACCT
GAAAAAACCTACACCTCTACAGCAGGTCGAATTCATGACCTGAAGCTGAATACTTCCAGCATATTTATTCAGGGTGTAGGTGGGAATAAA
GTATCTTCGCAGTGCTCTGTTCCCTCCGTCTCCCCAGACATCTGACACCCTAAAAGCCATCCACAGCTATGGAACCTGAGCGACACCTTG
ATTTGTGTTGTCACCTGACCAAGCCTAAAGACCTCCAGCTCAGTCCCCCACCTTCATCCCACCCCACAGATGATAAAATTCAGACCTCTC
TCCTGAAAGGCAGAGGTTCAACATTCAGGACTGTTTCTGGCCGAGGACTTCTTCCAATTAAAACCCCCACCGTGGGCTGTCTCCCCTCAT
TTCATTTTTCTAAAGGGGCAGAGGCCTCTTTTAGAAAATAATAAAATGCAATGTGTGTGATTTACTTTTCTGATCTCTTTGAGAAATAGA
GAAATATAAAAGTGTGTTCTTAACTCCAGAACCACTCTTTTTGCATAAATACCTCATCGGGCAGCTTTCTAAGTGTGATTTTCCTGAGTC
TCCCTTCGTTGGATCTGCCGGAAGACTTGTCGGGGAACCTTTAGTGAGGGTACTTCTTCCTATTTTTCTTCTGTTTTTGGAGGCATACAC
ATTATGCATAACCAAAACAATGGCTCAATTGTGTTTAACTTTGTATTTTGATTGTTGAGAACAAAAACAAAAAGTATCAATGTGTATGTG
GCTGTTTGTAGTGAATTTATTGGAGAATGAGGTTGTCCGTGTCCTTAACAAGCCAAGGGGCAGGAGGCACCCTCTCTTATCCCCTCCTCC
AAGAGCAGTAGAGAATTTAAGCACAAGCCTATTTGTGAAAGAATATTTTGCTTAAGTGTCATTCACTTTAGTCTTGGAATTCCTTCCCAA
ACGTCAGGTGTTCTTTTAGCTTCCAAACTAGCATATGTATCCATTAGTCTGACAGATCGCCTGAACACCATTAAGAGGTGTGGCGTTTTT
GCTTTCATTTCTCCTGCTGGGAGAAGTGGCGGTTCATGTGTCATTCCAGTATCTCACATACTCACACGGGGCAGGGGGGAGGGGGAAACG
GGGAACTATAGCAATATTTAAAGATGCTTTGGAAACCAACCGTGAACACATCAACACCACGACGTCTACGATTACTTGCTATTGGCCCTC
GGATACATTTAAGAGAAAGAGACAGTCACTCTTTTTTTTCTTAAATGATATACATATAAACAGTTATTTTTATCCTATTATAATTGTCTT
TTGTCTTTATCTAGTACTATGTGGAAAGGGTTTGCATCATAGATTTTTCCCAGCCTTATAATATACCATAAGCTCCTACTTCCCTGCCCC
TCCCTAATCAGTATTCTTTCAAGAGTTCTTTGGTGAAGCCATCTATCTGAAACTAAAATGAACCAAACCCATATTTCACTGGTGGTTGGA
GAAAACCATGGCCAAAACGATTGTGGCAGGTCTCAATCTTGGGAGTTTTTAAGAAGGAATGTGCCAGAGGCCGATTCCCAAGAACAGAGT
TTTCTTTTGTTTTGCAGAGGCATTCAATGTGTCTAGTGCTTGCTGGCCACAGCAGTTACTACCACAGAGCCTTCTGGGAGGGGCCGTTGT
GTTGAAGGAGGCTCCTGCCTGAGGGACAGCATCAGGCAGTGGGCTCTGTAGAGTGAGAACCAGGTGGAGGCCTTCTGTGCCCAGCTCAGA
GTTCTGCACCACGCCAGGACTGCCCAGGCCAAGGGCTACTGACGCAAGTTCCACTCATTCCACTCTGTGGGGGGCGCCTTGGGCCTCTCC
TGGAAGGGCTCTTGGAGAAGGAATTGGAGTTACGTACAAGTGACCTAAATGGGAAGCTTTTCTAGATGAGATTGGATTAAATTCCATGTG
ATTTCTCTTTCCCTTTAATCCAGGTTGGGACTCGTTTCTTTCTGGTGGATCACAGCTGCCCAGATGTTGCAATTGATTTTTATGTTTCTG
TAGAGAAGTATTTTTCTTTCATCTTCAGGATTTTTTTTGCCACCAAAAGAAAACATTGGAACTCTGTGTTTCCTCTTGATTGTGACTTCC
CAGTGTTGACAGTTAAGTCCTTAGTGTCGTAGGTCCCAGCCCACCAATACTATATCAAACACTGTTATGCACATAATGCAGCACTGTGAT
CTAATTTAAATAATACTTTTTTATTATTTATACTACTATATATAATATACATCAACACTTTTGCTATATAACCTAAGTGATAACCCTCTT
TTAGTTACCTGCCAAACTCTGGACTTGGTTTATATTGCAGTTAACACAGTTACAAAGCTGTAATGGTGTCTTTTTTTCCTTTGTAACGGA
ATGTGTAAATCAAAGTATATACATTGTGTGGTGTTCCTGTTTCTGGAGTTTCATGAGGATTTACACATGGCATTCAGTGTTCTGTATAGA
TCTGCCTACCTTTGTGAATTCATCTGTTAACCCCTCTTCCTTTGAGAGAGCACCGGCGATGGTGGTTAACTCCTTGTGTTTTCTCTCTCT
CCTACTGGTTATTCTTGAATTAAGCACAGACTCGTCAGCTCGGTTGCTTTATCATGAATAATGTGTGTGACCTTGCAGTTCTTCCACAGT
TCAGCAAACAAGTGCTAGCTTCACTGACCAAAAATTAAGGAAGGAAAACACAGTTTTTAAAACGATCCATCTTTTAACAGCCGAAACCGA
TGTGTCTATGGTGCTGCACCTTGCTGTTGTACTTCTGAAATCAGACGTGTGTGAACGATCATTTCTGACTTAACCGTGAGATGCTCACGA
GTACCCTTCCTGTTGTTTTGTTAGCATTGAAATCGAGACTATTTATTTGGAATATATACAACAGTGTTTTTCCACTGTATTTCATTTGCA
AAAGTTGAGAACTGCTTTCTCTACCTTTTGCAAAATAATTGATATTCCATATTGGATTCTCAAAGACTTCGATATGGTGAACCTATTAAA
CCTAGAAATTGTATTCATCCTTTCATGACTGTGGCCTGAGTTCCCCAGCCCCTCTCCTCCTTTTTTTTAGATGAGATTTAGCACACTCTC
AGTTATTTAAACATGCAACATTTCTTGAGTATGTATGTTGAGGCCATCTGAGCTCATAGCTGATTCAGTAACCAGTTTCATGCTGTGTCA
TTCACACTCACTACTTAATACTGCCATGGTGAAAATGTGGAGGAAAAATGTATCCATGTGTGTCTGGGAAGCATATACACTTGTACATTT
TTTAATACTCTGATTCTGTAACATTTCTGAGTTTTGTTTTGTTTTACAGAAAAAAAAAAAAAGTGATAAAGCAATCAGAAGACCAAGAGG
TTTACTATTGATGCTTAGGGTCGTCTGACCTTGGCTGGCCAATAGACCTACACGGCCAAATTAATTTACGAGAGTAATAATTTTTCAAAA
GCCAATTTTTTTTCTGTATTTTCTGTATGAAACTGCCAATATCATGAATAGAAAGGGAGAACCATAAAGGAGAAAGAACGTGATGTTCTG
TTATGTTCATGTAAACCTAAAGAAACAGTGTGGAGGCAGGCGCGATCAGCCGAACTCTAGGGACTTGGTGTTGCTTGGAAGGCATCCATA
CCTGCATTTTGCATTCTTCGTATGTAATCATATTGCCAAAGACAAACTATTTCATCATTTATTGTAAATAACACTTTTCCCCAGACCTAC

>94452_94452_1_TRPV6-FOXN3_TRPV6_chr7_142583133_ENST00000359396_FOXN3_chr14_89817152_ENST00000261302_length(amino acids)=303AA_BP=
MWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNTPPEIQAGFPPGVIQ
NGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYE
FATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAA

--------------------------------------------------------------
>94452_94452_2_TRPV6-FOXN3_TRPV6_chr7_142583133_ENST00000359396_FOXN3_chr14_89817152_ENST00000345097_length(transcript)=7546nt_BP=374nt
AGACAGGCCAGCCCTGCAGAGTCCTGGCTGGCTCTGCCAAGTGTAACAAACTCACAGCCCTCTCCAAACTGGCTGGGGCTGCTGGGAGAC
TCCCAAGGAACTCGTCAGGAAGGCAGGAGACAGGAGACGGGACCTCTACAGGGAGACGGTGGGCCGGCCCTTGGGGGGGCTGATGTGTCC
CCAAGGCTGAGTCCCGTCAGGGTCTGGCCTCGGCCTCAGGCCCCCAAGGAGCCGGCCCTACACCCCATGGGTTTGTCACTGCCCAAGGAG
AAAGGGCTAATTCTCTGCCTATGGAGCAAGTTCTGCAGATGGTTCCAGAGACGGGAGTCCTGGGCCCAGAGCCGAGATGAGCAGAACCTG
CTGCAGCAGAAGAGAGTATTGGGAAAGGGTCGTTGTGGTGCATAGACCCAGAGTATAGACAAAATCTAATTCAGGCTTTGAAAAAGACAC
CTTATCACCCACACCCACACGTGTTCAATACACCTCCCACCTGTCCTCAGGCATATCAAAGCACATCAGGTCCACCCATCTGGCCGGGCA
GTACCTTCTTCAAGAGAAATGGAGCCCTTCTCCAAGATCCTGACATTGATGCTGCCAGTGCCATGATGCTTTTGAATACTCCCCCTGAGA
TACAAGCAGGTTTTCCTCCAGGAGTGATCCAAAATGGAGCGCGGGTCCTGAGCCGAGGGCTGTTTCCTGGCGTGCGGCCGCTGCCAATCA
CTCCCATTGGGGTGACAGCGGCCATGAGGAATGGCATCACCAGCTGCCGGATGCGGACTGAGAGTGAGCCATCTTGTGGCTCCCCAGTGG
TCAGCGGAGACCCCAAGGAGGATCACAACTACAGCAGTGCCAAGTCCTCCAACGCCCGGAGCACCTCGCCCACCAGCGACTCCATCTCCT
CCTCCTCCTCCTCAGCCGACGACCACTATGAGTTTGCCACCAAGGGGAGCCAGGAGGGCAGCGAGGGCAGCGAGGGGAGCTTCCGGAGCC
ACGAGAGCCCCAGCGACACGGAAGAGGACGACAGGAAGCACAGCCAGAAGGAGCCCAAGGATTCTCTGGGGGACAGCGGGTACGCATCCC
AGCACAAGAAGCGCCAGCACTTCGCCAAGGCCAGGAAGGTCCCCAGCGACACACTGCCCCTCAAAAAGAGACGCACCGAAAAGCCCCCCG
AGAGCGATGATGAGGAGATGAAAGAAGCGGCAGGGTCCCTCCTGCACTTAGCAGGGATCCGGTCCTGTTTGAATAACATCACCAATCGGA
CGGCAAAGGGGCAGAAAGAGCAAAAGGAAACCACAAAAAATTAAAAACAAGTCACTGATTTGTTTTGAACTTACGACCATTTGGTTTCAG
CATGTCAGGAGATTTCTAATGATTTGTGGCAATATCAGCAATTTTTTTTCTTTTTTCTTGTTTTTGGTTTGGTTTTCTTTCTTTTCTTTT
CCTTTTATTTTGTTTTAATTTGCCCCCTCTTCTTTGTTTTGGACCCTTAAGAATTTTATTTTTAAAGGAGATTGAAGCCATAGAACTCAT
ATTGACACTCAGCTGTTTTACAAAAGCTTTTCATTATCTGAAGACAAAACCGAAAAAGCCAAAATTACCATTGCTTCCTCCAGCTTGTCA
GAAACCTGTGGCTGAATCCGCAGGGATGTCAACGTCAATATCACAGGAACACACATTCGGCACCTAGAAGGCACGTGGGCAAAGTAATCA
TCGTTCAGGCCCAACCCTTAGGTTTAAAAAGTCAGGTTGTCCATCCCATTGGGTTCACTGAGTGAAGGCACATAAAGCAATTGAGGAGGA
GGAGGAACCCCTCGTCCCCCTAGGAGCAGACCCAAGCTTGTGGCACCAGGCATCTGATGGTGCCAGGAAAGCCACTGGAATTGTCACACG
GCGAGCACAGAGGGCCGGCCACCAGTCCTCGATGCTTCTGAACCCTGAAGCCCGATGACATCTTACGAGGTGGACGTTGGACTGTTCATG
CGCATCGGGTGTCAGTGACTCATGGAGAAGAAATGGGGTAAATTTTTAGTGATGTTGCTAATCATTGAATTCTGTTCTCTATTAAATTAA
GAAAATGTTCCAAAAGCCATAAGCCTGAAGATTGGCCCTGTGCACGCACGCACACACACACACACACACACACACACACACACACACACA
CGAAGGAGAGAGAGAGAAAACTGATGGGGAAAACAAGCTGTGTCTTCTTAACTGCCCAAGTGAAAAGCAACCAAGTCCAGGAAATTACAA
TAGCTGTTAAGGAAAGGAAATAATGGTACAGATCTTTTTCTGTCTATCAAAACTATTTGATCCAAGTGAAAAAAAAAAAAAAACTAGAAA
GCTACGGAACCTGCCATTAGTATTGTGGTGTATTTTTAAGATTAAAGGTACACTGATGGACAAAAAAAAAAAGTAAAACATGGCAAAAAA
TAAAATAACTCCTATACTGCCCTCAAAATGGAGTTTGCAATTAATATCAGGATTTATCTTTGCAAAAATCAGTGATTTCCACATTCAGCC
AGTATAGCCAGCAGAAATTTCTGATCCACAATGCATGGATTCCTTTGAAGAAAAAAAAGAAAAAGAGAAAAAAATCACAAAAACAAACTT
TTTTTATTCAAAAGTAACAAAGTTCTTGTAAGGTAAATAATGTATTTAGCATGAAGCATGAATTATTTTCATATAAATATAGAAAATAGA
GAAAAGGCTATGCCTGTAATTTTTAAGCCCTTAGGCTTAGAGTTTCTTTTGGTTTTCTTCTTTTTTCTTTCCTTTTCTTTGCTTTCTTTT
TTTCCTTTTTGTTTTTGTTTTTGTTTTTTGTTTTTGTTTTTTTTTCGGGTTATTTTGTTTTGGTTTTTTGAAGCAGGTGTTTAAGGTTTA
ACCTTCTTCAGGGACAAATTCTGACTGTTGGGGAACTTACTCTGCAATATAAAAATATCTTCATGCTCTGGTAGGGCTTGGATGGTTGAA
CTCTGTACTGCCTTGTGTGCACTTCAGCCCCGACCCCCTCTGATTCTCTGTTGAAAAGTGTGTCCTTTCTCTCTGTCTGTACATGTTTAA
CATGACGCAATAATTTGAGGGCAAACTTAGTAGTGAGTGTGTATGATAGAATCAAGAGAATTATGGGACGCTTACTTGAGAAAATCATTA
CCATGATTTGGTTCTAGGAAAAAGGCAGTGAATAATTATGCAAATTAGCCAGAAGAAGGGGAACCGTGCTAATGGGCCTTATTGGGTGAG
GGGACGAGATGGGGTTCATGTGAAGGAGGAAGCGATGCCGAGGTAGGAAAGGCCAGCCCCAGACATCCTATCGCCACAATGCCATGTCGC
AATAGGAAGCAGGGGCCGGCCATCGCTACCTTCAGCACACTGACCAACCTGGAATTAAGACCACCTAGATTGCGAGAGCTGAATTTAGAA
ACCAGACAACGTCATGCAGCCCAGAAACTCCTGTTGTTACCTTTGCCTAAGAAATTTTCTTTAATGGCGGGGGCGGGGGGCGGGGGTACA
AAGAGAAATCTCTAAAAGAATATGATCTTCCATCCAAGTGGAGGGAAACTTTAAAACAAAAACACCCAGTACTGTGGCTCAGGATATGAT
GCGTGAGGAGAGGGAGGGAACAGAGATGACCTTAACTTTTAAAAAAGGGACTGCTGTGGGCCAAAGCCAAGCCCATCTGCCAGGACGAGG
TAATGTCAGAGCTCCATCAGCCCGGACAGTGGGAACTAACTGGTGCATTCCCCACACTTACCTTCCGGTGGGTTGCTGATGAGAGAACCT
GAAAAAACCTACACCTCTACAGCAGGTCGAATTCATGACCTGAAGCTGAATACTTCCAGCATATTTATTCAGGGTGTAGGTGGGAATAAA
GTATCTTCGCAGTGCTCTGTTCCCTCCGTCTCCCCAGACATCTGACACCCTAAAAGCCATCCACAGCTATGGAACCTGAGCGACACCTTG
ATTTGTGTTGTCACCTGACCAAGCCTAAAGACCTCCAGCTCAGTCCCCCACCTTCATCCCACCCCACAGATGATAAAATTCAGACCTCTC
TCCTGAAAGGCAGAGGTTCAACATTCAGGACTGTTTCTGGCCGAGGACTTCTTCCAATTAAAACCCCCACCGTGGGCTGTCTCCCCTCAT
TTCATTTTTCTAAAGGGGCAGAGGCCTCTTTTAGAAAATAATAAAATGCAATGTGTGTGATTTACTTTTCTGATCTCTTTGAGAAATAGA
GAAATATAAAAGTGTGTTCTTAACTCCAGAACCACTCTTTTTGCATAAATACCTCATCGGGCAGCTTTCTAAGTGTGATTTTCCTGAGTC
TCCCTTCGTTGGATCTGCCGGAAGACTTGTCGGGGAACCTTTAGTGAGGGTACTTCTTCCTATTTTTCTTCTGTTTTTGGAGGCATACAC
ATTATGCATAACCAAAACAATGGCTCAATTGTGTTTAACTTTGTATTTTGATTGTTGAGAACAAAAACAAAAAGTATCAATGTGTATGTG
GCTGTTTGTAGTGAATTTATTGGAGAATGAGGTTGTCCGTGTCCTTAACAAGCCAAGGGGCAGGAGGCACCCTCTCTTATCCCCTCCTCC
AAGAGCAGTAGAGAATTTAAGCACAAGCCTATTTGTGAAAGAATATTTTGCTTAAGTGTCATTCACTTTAGTCTTGGAATTCCTTCCCAA
ACGTCAGGTGTTCTTTTAGCTTCCAAACTAGCATATGTATCCATTAGTCTGACAGATCGCCTGAACACCATTAAGAGGTGTGGCGTTTTT
GCTTTCATTTCTCCTGCTGGGAGAAGTGGCGGTTCATGTGTCATTCCAGTATCTCACATACTCACACGGGGCAGGGGGGAGGGGGAAACG
GGGAACTATAGCAATATTTAAAGATGCTTTGGAAACCAACCGTGAACACATCAACACCACGACGTCTACGATTACTTGCTATTGGCCCTC
GGATACATTTAAGAGAAAGAGACAGTCACTCTTTTTTTTCTTAAATGATATACATATAAACAGTTATTTTTATCCTATTATAATTGTCTT
TTGTCTTTATCTAGTACTATGTGGAAAGGGTTTGCATCATAGATTTTTCCCAGCCTTATAATATACCATAAGCTCCTACTTCCCTGCCCC
TCCCTAATCAGTATTCTTTCAAGAGTTCTTTGGTGAAGCCATCTATCTGAAACTAAAATGAACCAAACCCATATTTCACTGGTGGTTGGA
GAAAACCATGGCCAAAACGATTGTGGCAGGTCTCAATCTTGGGAGTTTTTAAGAAGGAATGTGCCAGAGGCCGATTCCCAAGAACAGAGT
TTTCTTTTGTTTTGCAGAGGCATTCAATGTGTCTAGTGCTTGCTGGCCACAGCAGTTACTACCACAGAGCCTTCTGGGAGGGGCCGTTGT
GTTGAAGGAGGCTCCTGCCTGAGGGACAGCATCAGGCAGTGGGCTCTGTAGAGTGAGAACCAGGTGGAGGCCTTCTGTGCCCAGCTCAGA
GTTCTGCACCACGCCAGGACTGCCCAGGCCAAGGGCTACTGACGCAAGTTCCACTCATTCCACTCTGTGGGGGGCGCCTTGGGCCTCTCC
TGGAAGGGCTCTTGGAGAAGGAATTGGAGTTACGTACAAGTGACCTAAATGGGAAGCTTTTCTAGATGAGATTGGATTAAATTCCATGTG
ATTTCTCTTTCCCTTTAATCCAGGTTGGGACTCGTTTCTTTCTGGTGGATCACAGCTGCCCAGATGTTGCAATTGATTTTTATGTTTCTG
TAGAGAAGTATTTTTCTTTCATCTTCAGGATTTTTTTTGCCACCAAAAGAAAACATTGGAACTCTGTGTTTCCTCTTGATTGTGACTTCC
CAGTGTTGACAGTTAAGTCCTTAGTGTCGTAGGTCCCAGCCCACCAATACTATATCAAACACTGTTATGCACATAATGCAGCACTGTGAT
CTAATTTAAATAATACTTTTTTATTATTTATACTACTATATATAATATACATCAACACTTTTGCTATATAACCTAAGTGATAACCCTCTT
TTAGTTACCTGCCAAACTCTGGACTTGGTTTATATTGCAGTTAACACAGTTACAAAGCTGTAATGGTGTCTTTTTTTCCTTTGTAACGGA
ATGTGTAAATCAAAGTATATACATTGTGTGGTGTTCCTGTTTCTGGAGTTTCATGAGGATTTACACATGGCATTCAGTGTTCTGTATAGA
TCTGCCTACCTTTGTGAATTCATCTGTTAACCCCTCTTCCTTTGAGAGAGCACCGGCGATGGTGGTTAACTCCTTGTGTTTTCTCTCTCT
CCTACTGGTTATTCTTGAATTAAGCACAGACTCGTCAGCTCGGTTGCTTTATCATGAATAATGTGTGTGACCTTGCAGTTCTTCCACAGT
TCAGCAAACAAGTGCTAGCTTCACTGACCAAAAATTAAGGAAGGAAAACACAGTTTTTAAAACGATCCATCTTTTAACAGCCGAAACCGA
TGTGTCTATGGTGCTGCACCTTGCTGTTGTACTTCTGAAATCAGACGTGTGTGAACGATCATTTCTGACTTAACCGTGAGATGCTCACGA
GTACCCTTCCTGTTGTTTTGTTAGCATTGAAATCGAGACTATTTATTTGGAATATATACAACAGTGTTTTTCCACTGTATTTCATTTGCA
AAAGTTGAGAACTGCTTTCTCTACCTTTTGCAAAATAATTGATATTCCATATTGGATTCTCAAAGACTTCGATATGGTGAACCTATTAAA
CCTAGAAATTGTATTCATCCTTTCATGACTGTGGCCTGAGTTCCCCAGCCCCTCTCCTCCTTTTTTTTAGATGAGATTTAGCACACTCTC
AGTTATTTAAACATGCAACATTTCTTGAGTATGTATGTTGAGGCCATCTGAGCTCATAGCTGATTCAGTAACCAGTTTCATGCTGTGTCA
TTCACACTCACTACTTAATACTGCCATGGTGAAAATGTGGAGGAAAAATGTATCCATGTGTGTCTGGGAAGCATATACACTTGTACATTT
TTTAATACTCTGATTCTGTAACATTTCTGAGTTTTGTTTTGTTTTACAGAAAAAAAAAAAAAGTGATAAAGCAATCAGAAGACCAAGAGG
TTTACTATTGATGCTTAGGGTCGTCTGACCTTGGCTGGCCAATAGACCTACACGGCCAAATTAATTTACGAGAGTAATAATTTTTCAAAA
GCCAATTTTTTTTCTGTATTTTCTGTATGAAACTGCCAATATCATGAATAGAAAGGGAGAACCATAAAGGAGAAAGAACGTGATGTTCTG
TTATGTTCATGTAAACCTAAAGAAACAGTGTGGAGGCAGGCGCGATCAGCCGAACTCTAGGGACTTGGTGTTGCTTGGAAGGCATCCATA
CCTGCATTTTGCATTCTTCGTATGTAATCATATTGCCAAAGACAAACTATTTCATCATTTATTGTAAATAACACTTTTCCCCAGACCTAC

>94452_94452_2_TRPV6-FOXN3_TRPV6_chr7_142583133_ENST00000359396_FOXN3_chr14_89817152_ENST00000345097_length(amino acids)=303AA_BP=
MWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNTPPEIQAGFPPGVIQ
NGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYE
FATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAA

--------------------------------------------------------------
>94452_94452_3_TRPV6-FOXN3_TRPV6_chr7_142583133_ENST00000359396_FOXN3_chr14_89817152_ENST00000555353_length(transcript)=1290nt_BP=374nt
AGACAGGCCAGCCCTGCAGAGTCCTGGCTGGCTCTGCCAAGTGTAACAAACTCACAGCCCTCTCCAAACTGGCTGGGGCTGCTGGGAGAC
TCCCAAGGAACTCGTCAGGAAGGCAGGAGACAGGAGACGGGACCTCTACAGGGAGACGGTGGGCCGGCCCTTGGGGGGGCTGATGTGTCC
CCAAGGCTGAGTCCCGTCAGGGTCTGGCCTCGGCCTCAGGCCCCCAAGGAGCCGGCCCTACACCCCATGGGTTTGTCACTGCCCAAGGAG
AAAGGGCTAATTCTCTGCCTATGGAGCAAGTTCTGCAGATGGTTCCAGAGACGGGAGTCCTGGGCCCAGAGCCGAGATGAGCAGAACCTG
CTGCAGCAGAAGAGAGTATTGGGAAAGGGTCGTTGTGGTGCATAGACCCAGAGTATAGACAAAATCTAATTCAGGCTTTGAAAAAGACAC
CTTATCACCCACACCCACACGTGTTCAATACACCTCCCACCTGTCCTCAGGCATATCAAAGCACATCAGGTCCACCCATCTGGCCGGGCA
GTACCTTCTTCAAGAGAAATGGAGCCCTTCTCCAAGTTCCTCCAGGAGTGATCCAAAATGGAGCGCGGGTCCTGAGCCGAGGGCTGTTTC
CTGGCGTGCGGCCGCTGCCAATCACTCCCATTGGGGTGACAGCGGCCATGAGGAATGGCATCACCAGCTGCCGGATGCGGACTGAGAGTG
AGCCATCTTGTGGCTCCCCAGTGGTCAGCGGAGACCCCAAGGAGGATCACAACTACAGCAGTGCCAAGTCCTCCAACGCCCGGAGCACCT
CGCCCACCAGCGACTCCATCTCCTCCTCCTCCTCCTCAGCCGACGACCACTATGAGTTTGCCACCAAGGGGAGCCAGGAGGGCAGCGAGG
GCAGCGAGGGGAGCTTCCGGAGCCACGAGAGCCCCAGCGACACGGAAGAGGACGACAGGAAGCACAGCCAGAAGGAGCCCAAGGATTCTC
TGGGGGACAGCGGGTACGCATCCCAGCACAAGAAGCGCCAGCACTTCGCCAAGGCCAGGAAGGTCCCCAGCGACACACTGCCCCTCAAAA
AGAGACGCACCGAAAAGCCCCCCGAGAGCGATGATGAGGAGATGAAAGAAGCGGCAGGGTCCCTCCTGCACTTAGCAGGGATCCGGTCCT
GTTTGAATAACATCACCAATCGGACGGCAAAGGGGCAGAAAGAGCAAAAGGAAACCACAAAAAATTAAAAACAAGTCACTGATTTGTTTT

>94452_94452_3_TRPV6-FOXN3_TRPV6_chr7_142583133_ENST00000359396_FOXN3_chr14_89817152_ENST00000555353_length(amino acids)=281AA_BP=
MWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQVPPGVIQNGARVLSRGLFPGVRPLPITPI
GVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFRSHES
PSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAK

--------------------------------------------------------------
>94452_94452_4_TRPV6-FOXN3_TRPV6_chr7_142583133_ENST00000359396_FOXN3_chr14_89817152_ENST00000557258_length(transcript)=2267nt_BP=374nt
AGACAGGCCAGCCCTGCAGAGTCCTGGCTGGCTCTGCCAAGTGTAACAAACTCACAGCCCTCTCCAAACTGGCTGGGGCTGCTGGGAGAC
TCCCAAGGAACTCGTCAGGAAGGCAGGAGACAGGAGACGGGACCTCTACAGGGAGACGGTGGGCCGGCCCTTGGGGGGGCTGATGTGTCC
CCAAGGCTGAGTCCCGTCAGGGTCTGGCCTCGGCCTCAGGCCCCCAAGGAGCCGGCCCTACACCCCATGGGTTTGTCACTGCCCAAGGAG
AAAGGGCTAATTCTCTGCCTATGGAGCAAGTTCTGCAGATGGTTCCAGAGACGGGAGTCCTGGGCCCAGAGCCGAGATGAGCAGAACCTG
CTGCAGCAGAAGAGAGTATTGGGAAAGGGTCGTTGTGGTGCATAGACCCAGAGTATAGACAAAATCTAATTCAGGCTTTGAAAAAGACAC
CTTATCACCCACACCCACACGTGTTCAATACACCTCCCACCTGTCCTCAGGCATATCAAAGCACATCAGGTCCACCCATCTGGCCGGGCA
GTACCTTCTTCAAGAGAAATGGAGCCCTTCTCCAAGTTCCTCCAGGAGTGATCCAAAATGGAGCGCGGGTCCTGAGCCGAGGGCTGTTTC
CTGGCGTGCGGCCGCTGCCAATCACTCCCATTGGGGTGACAGCGGCCATGAGGAATGGCATCACCAGCTGCCGGATGCGGACTGAGAGTG
AGCCATCTTGTGGCTCCCCAGTGGTCAGCGGAGACCCCAAGGAGGATCACAACTACAGCAGTGCCAAGTCCTCCAACGCCCGGAGCACCT
CGCCCACCAGCGACTCCATCTCCTCCTCCTCCTCCTCAGCCGACGACCACTATGAGTTTGCCACCAAGGGGAGCCAGGAGGGCAGCGAGG
GCAGCGAGGGGAGCTTCCGGAGCCACGAGAGCCCCAGCGACACGGAAGAGGACGACAGGAAGCACAGCCAGAAGGAGCCCAAGGATTCTC
TGGGGGACAGCGGGTACGCATCCCAGCACAAGAAGCGCCAGCACTTCGCCAAGGCCAGGAAGGTCCCCAGCGACACACTGCCCCTCAAAA
AGAGACGCACCGAAAAGCCCCCCGAGAGCGATGATGAGGAGATGAAAGAAGCGGCAGGGTCCCTCCTGCACTTAGCAGGGATCCGGTCCT
GTTTGAATAACATCACCAATCGGACGGCAAAGGGGCAGAAAGAGCAAAAGGAAACCACAAAAAATTAAAAACAAGTCACTGATTTGTTTT
GAACTTACGACCATTTGGTTTCAGCATGTCAGGAGATTTCTAATGATTTGTGGCAATATCAGCAATTTTTTTTCTTTTTTCTTGTTTTTG
GTTTGGTTTTCTTTCTTTTCTTTTCCTTTTATTTTGTTTTAATTTGCCCCCTCTTCTTTGTTTTGGACCCTTAAGAATTTTATTTTTAAA
GGAGATTGAAGCCATAGAACTCATATTGACACTCAGCTGTTTTACAAAAGCTTTTCATTATCTGAAGACAAAACCGAAAAAGCCAAAATT
ACCATTGCTTCCTCCAGCTTGTCAGAAACCTGTGGCTGAATCCGCAGGGATGTCAACGTCAATATCACAGGAACACACATTCGGCACCTA
GAAGGCACGTGGGCAAAGTAATCATCGTTCAGGCCCAACCCTTAGGTTTAAAAAGTCAGGTTGTCCATCCCATTGGGTTCACTGAGTGAA
GGCACATAAAGCAATTGAGGAGGAGGAGGAACCCCTCGTCCCCCTAGGAGCAGACCCAAGCTTGTGGCACCAGGCATCTGATGGTGCCAG
GAAAGCCACTGGAATTGTCACACGGCGAGCACAGAGGGCCGGCCACCAGTCCTCGATGCTTCTGAACCCTGAAGCCCGATGACATCTTAC
GAGGTGGACGTTGGACTGTTCATGCGCATCGGGTGTCAGTGACTCATGGAGAAGAAATGGGGTAAATTTTTAGTGATGTTGCTAATCATT
GAATTCTGTTCTCTATTAAATTAAGAAAATGTTCCAAAAGCCATAAGCCTGAAGATTGGCCCTGTGCACGCACGCACACACACACACACA
CACACACACACACACACACACACACGAAGGAGAGAGAGAGAAAACTGATGGGGAAAACAAGCTGTGTCTTCTTAACTGCCCAAGTGAAAA
GCAACCAAGTCCAGGAAATTACAATAGCTGTTAAGGAAAGGAAATAATGGTACAGATCTTTTTCTGTCTATCAAAACTATTTGATCCAAG

>94452_94452_4_TRPV6-FOXN3_TRPV6_chr7_142583133_ENST00000359396_FOXN3_chr14_89817152_ENST00000557258_length(amino acids)=281AA_BP=
MWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQVPPGVIQNGARVLSRGLFPGVRPLPITPI
GVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFRSHES
PSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TRPV6-FOXN3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	TRPV6	chr7:142583133	chr14:89817152	ENST00000359396	-	1	15	133_143	42.666666666666664	726.0	calmodulin
Hgene	TRPV6	chr7:142583133	chr14:89817152	ENST00000359396	-	1	15	731_751	42.666666666666664	726.0	calmodulin
Hgene	TRPV6	chr7:142583133	chr14:89817152	ENST00000359396	-	1	15	638_642	42.666666666666664	726.0	S100A10

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TRPV6-FOXN3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TRPV6-FOXN3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source