FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TSC22D1-CAPZA2 (FusionGDB2 ID:94480)

Fusion Gene Summary for TSC22D1-CAPZA2

check button Fusion gene summary
Fusion gene informationFusion gene name: TSC22D1-CAPZA2
Fusion gene ID: 94480
HgeneTgene
Gene symbol

TSC22D1

CAPZA2

Gene ID

8848

830

Gene nameTSC22 domain family member 1capping actin protein of muscle Z-line subunit alpha 2
SynonymsPtg-2|TGFB1I4|TSC22CAPPA2|CAPZ
Cytomap

13q14.11

7q31.2

Type of geneprotein-codingprotein-coding
DescriptionTSC22 domain family protein 1TGFB-stimulated clone 22 homologTGFbeta-stimulated clone 22cerebral protein 2regulatory protein TSC-22transcriptional regulator TSC-22transforming growth factor beta-1-induced transcript 4 proteintransforming growth facF-actin-capping protein subunit alpha-2F-actin capping protein alpha-2 subunitcapZ alpha-2capping actin protein of muscle Z-line alpha subunit 2capping protein (actin filament) muscle Z-line, alpha 2epididymis secretory sperm binding protein
Modification date2020031320200313
UniProtAcc.

P47755

Ensembl transtripts involved in fusion geneENST00000458659, ENST00000460842, 
ENST00000261489, ENST00000501704, 
ENST00000466023, ENST00000361183, 
ENST00000458284, ENST00000490693, 
Fusion gene scores* DoF score22 X 19 X 8=33448 X 5 X 7=280
# samples 258
** MAII scorelog2(25/3344*10)=-3.7415748474188
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSC22D1 [Title/Abstract] AND CAPZA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSC22D1(45147299)-CAPZA2(116528181), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TSC22D1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAPZA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A1FV-01ATSC22D1chr13

45147299

-CAPZA2chr7

116528181

+


Top

Fusion Gene ORF analysis for TSC22D1-CAPZA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000458659ENST00000466023TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
5UTR-3CDSENST00000460842ENST00000361183TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
5UTR-3CDSENST00000460842ENST00000458284TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
5UTR-3CDSENST00000460842ENST00000490693TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
5UTR-intronENST00000460842ENST00000466023TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
In-frameENST00000458659ENST00000361183TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
In-frameENST00000458659ENST00000458284TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
In-frameENST00000458659ENST00000490693TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
intron-3CDSENST00000261489ENST00000361183TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
intron-3CDSENST00000261489ENST00000458284TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
intron-3CDSENST00000261489ENST00000490693TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
intron-3CDSENST00000501704ENST00000361183TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
intron-3CDSENST00000501704ENST00000458284TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
intron-3CDSENST00000501704ENST00000490693TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
intron-intronENST00000261489ENST00000466023TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+
intron-intronENST00000501704ENST00000466023TSC22D1chr13

45147299

-CAPZA2chr7

116528181

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000458659TSC22D1chr1345147299-ENST00000361183CAPZA2chr7116528181+840734034913412973
ENST00000458659TSC22D1chr1345147299-ENST00000458284CAPZA2chr7116528181+473434034913412973
ENST00000458659TSC22D1chr1345147299-ENST00000490693CAPZA2chr7116528181+416134034913412973

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000458659ENST00000361183TSC22D1chr1345147299-CAPZA2chr7116528181+0.0001769830.99982303
ENST00000458659ENST00000458284TSC22D1chr1345147299-CAPZA2chr7116528181+0.0010475170.9989525
ENST00000458659ENST00000490693TSC22D1chr1345147299-CAPZA2chr7116528181+0.0011542030.9988458

Top

Fusion Genomic Features for TSC22D1-CAPZA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TSC22D1chr1345147298-CAPZA2chr7116528180+2.91E-070.99999976
TSC22D1chr1345147298-CAPZA2chr7116528180+2.91E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for TSC22D1-CAPZA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:45147299/chr7:116528181)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAPZA2

P47755

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000458659-13195_2419701074.0Compositional biasNote=His-rich
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000458659-13497_8179701074.0Compositional biasNote=Gln-rich
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000458659-1359_829701074.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000261489-13195_2410145.0Compositional biasNote=His-rich
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000261489-13497_8170145.0Compositional biasNote=Gln-rich
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000261489-1359_820145.0Compositional biasNote=Pro-rich
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000501704-12195_2410571.0Compositional biasNote=His-rich
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000501704-12497_8170571.0Compositional biasNote=Gln-rich
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000501704-1259_820571.0Compositional biasNote=Pro-rich
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000261489-131006_10270145.0RegionNote=Leucine-zipper
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000458659-131006_10279701074.0RegionNote=Leucine-zipper
HgeneTSC22D1chr13:45147299chr7:116528181ENST00000501704-121006_10270571.0RegionNote=Leucine-zipper


Top

Fusion Gene Sequence for TSC22D1-CAPZA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94480_94480_1_TSC22D1-CAPZA2_TSC22D1_chr13_45147299_ENST00000458659_CAPZA2_chr7_116528181_ENST00000361183_length(transcript)=8407nt_BP=3403nt
CCGGGGGTGGCGAGGGGAAGGCGACATTTGCTTGGCGCTGCCTCCGTGCAGAGCGGCCGGGAGGGCTTTGCAGCGGCCGCCGACGCGGCG
GGAGGAGGGGGCTGAGGCGGCTTCGGAGTTGGCCGGAGAAGGTGGGCATTTCTCGCTTTTCCTCCCCTTCCTGCGCTCTCCCCCTCCCTC
CTGCCCCGCACCCCACGTGAAGCAGAATATAAAGGGGGGTGTGAGGCTAGAGGGGAAAGTGAATGGCGAAGGACTGAAGGGATCCCCCCT
TCGGGTCCCCGGCCGCCCTGTTCACCCTCGTTCATCCTCCTTTCCGAAGCTCGCTCTCGAAGGCAGGAGCGACCGGCGCCTTTGGCTGAG
GAGGAGGAGAAGGAGGAATCGCGCCAGGCGGAGCGTCAGGTCCCGTTTTCCTCTCCGGCGTCTCCAATACAAAGATTACGGTGCAGAAGG
AAATTGCACTCGTCTCCTCCGCGCCCCCGGTACCCAACACAATGCACCAGCCGCCTGAGTCCACCGCCGCGGCCGCCGCCGCTGCAGACA
TTAGCGCTAGGAAGATGGCGCACCCGGCAATGTTCCCTCGAAGGGGCAGCGGTAGTGGCAGCGCCTCTGCTCTCAATGCAGCAGGTACCG
GCGTCGGTAGTAATGCCACATCTTCCGAGGATTTTCCGCCTCCGTCGCTGCTTCAGCCGCCGCCCCCTGCAGCATCTTCTACGTCGGGAC
CACAGCCTCCGCCTCCACAAAGCCTGAACCTCCTTTCGCAGGCTCAGCTGCAGGCACAGCCTCTTGCGCCAGGCGGAACTCAAATGAAAA
AGAAAAGTGGCTTCCAGATAACTAGCGTTACTCCTGCTCAGATCTCCGCTAGTATCAGCTCTAACAACAGTATAGCAGAGGACACTGAGA
GCTATGATGATCTGGATGAATCTCACACGGAAGATCTCTCTTCTTCGGAGATCCTTGATGTGTCACTTTCCAGGGCTACTGACTTAGGGG
AGCCCGAACGCAGCTCCTCAGAAGAGACCCTAAATAACTTCCAGGAAGCCGAGACACCTGGGGCAGTCTCTCCCAACCAGCCCCACCTTC
CTCAGCCTCATTTGCCTCACCTTCCACAACAGAATGTTGTGATCAATGGGAATGCTCATCCACACCACCTCCATCACCACCATCAGATTC
ATCATGGGCACCACCTCCAACATGGTCACCACCATCCATCTCATGTTGCTGTGGCCAGTGCATCCATTACTGGTGGGCCACCCTCAAGCC
CAGTATCTAGAAAACTCTCTACAACTGGAAGCTCTGACAGTATCACACCAGTTGCACCAACTTCTGCTGTATCATCCAGTGGTTCACCTG
CATCTGTAATGACTAATATGCGTGCTCCAAGTACTACAGGTGGAATAGGTATAAATTCTGTTACTGGCACTAGTACAGTAAATAATGTTA
ACATTACTGCTGTGGGTAGTTTTAATCCTAATGTGACAAGCAGCATGCTTGGTAATGTTAATATAAGTACAAGCAATATTCCTAGTGCTG
CTGGTGTGAGTGTTGGGCCTGGAGTTACCAGTGGTGTTAATGTGAATATCTTGAGTGGCATGGGCAATGGTACTATTTCTTCCTCTGCTG
CTGTTAGCAGTGTTCCTAATGCAGCTGCAGGGATGACTGGGGGATCGGTTTCAAGTCAGCAGCAACAACCAACAGTTAACACTTCGAGGT
TCAGAGTTGTGAAGTTAGATTCTAGTTCTGAGCCCTTTAAAAAAGGTAGATGGACTTGCACTGAGTTCTATGAAAAAGAAAATGCTGTAC
CTGCTACAGAAGGTGTGCTGATAAATAAAGTGGTGGAGACTGTAAAGCAAAATCCGATAGAAGTGACTTCTGAAAGGGAGAGCACTAGTG
GGAGTTCAGTGAGCAGTAGTGTCAGCACACTGAGTCACTATACAGAGAGTGTGGGAAGTGGAGAGATGGGAGCCCCTACTGTGGTGGTGC
AGCAGCAGCAGCAGCAACAACAACAACAACAGCAACAACCAGCTCTCCAAGGTGTGACCCTCCAACAGATGGATTTTGGTAGCACTGGTC
CACAGAGTATTCCAGCAGTTAGTATACCACAGAGTATTTCTCAGTCACAGATCTCACAAGTACAATTACAGTCTCAAGAACTGAGCTATC
AGCAAAAGCAAGGTCTTCAGCCAGTACCTCTGCAAGCCACTATGAGTGCTGCAACTGGTATCCAGCCATCGCCTGTAAATGTGGTTGGTG
TAACTTCAGCTTTAGGTCAGCAGCCTTCCATTTCCAGTTTGGCTCAACCCCAGCTACCATATTCTCAGGCGGCTCCTCCAGTGCAAACTC
CCCTTCCAGGGGCACCACCACCCCAACAGTTACAGTATGGACAACAGCAACCAATGGTTTCTACACAGATGGCCCCAGGCCATGTCAAAT
CAGTGACTCAAAATCCTGCTTCAGAGTATGTACAACAGCAGCCAATTCTTCAAACAGCAATGTCCTCCGGACAGCCCAGTTCTGCAGGAG
TAGGAGCAGGAACAACAGTGATTCCTGTGGCTCAGCCACAGGGTATCCAGCTGCCAGTGCAGCCCACAGCAGTCCCAGCACAACCTGCAG
GGGCATCTGTCCAGCCTGTTGGCCAGGCTCCGGCAGCAGTGTCTGCTGTACCTACTGGCAGTCAGATTGCAAATATTGGTCAGCAAGCAA
ACATACCTACTGCAGTGCAGCAGCCCTCTACCCAGGTTCCACCTTCAGTTATTCAGCAGGGTGCTCCTCCATCTTCGCAAGTGGTTCCAC
CTGCTCAAACTGGGATTATTCATCAGGGAGTTCAAACTAGTGCTCCAAGCCTTCCTCAACAATTGGTTATTGCATCCCAAAGTTCCTTGT
TAACTGTGCCTCCCCAGCCACAAGGAGTAGAACCAGTAGCTCAAGGAATTGTTTCACAGCAGTTGCCTGCAGTTAGTTCTTTGCCCTCTG
CTAGTAGTATTTCTGTTACAAGTCAGGTTAGTTCAACTGGTCCTTCTGGAATGCCTTCTGCCCCAACAAACTTGGTTCCACCACAAAATA
TAGCACAAACCCCTGCTACCCAAAATGGTAATTTGGTTCAAAGTGTTAGTCAACCTCCCTTGATAGCAACTAATACAAATTTGCCTTTGG
CACAACAGATACCACTAAGTTCTACCCAGTTCTCCGCACAATCATTAGCTCAGGCAATTGGAAGCCAAATTGAAGATGCCAGGCGTGCAG
CGGAGCCCTCCTTAGTTGGCTTACCTCAGACTATCAGTGGTGACAGTGGGGGAATGTCAGCAGTTTCAGATGGGAGTAGCAGCAGCCTAG
CAGCCTCTGCTTCTCTTTTCCCGTTGAAGGTGCTACCGCTGACGACACCCCTGGTGGATGGCGAGGATGAGAGGTGCGTATAGCAGCAAA
ATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTTCGGTTACTGCTTAATAATGACAATCTTCTCAGGGAAGG
AGCAGCCCATGCATTTGCACAGTATAACTTGGACCAGTTTACTCCAGTAAAAATTGAAGGTTATGAAGATCAGGTATTGATAACAGAACA
TGGCGACTTGGGAAATGGAAAGTTTTTGGATCCAAAGAACAGAATCTGTTTTAAATTTGATCACTTAAGGAAGGAGGCAACTGATCCAAG
ACCCTGTGAAGTAGAAAATGCAGTTGAATCATGGAGAACTTCAGTAGAAACTGCTCTGAGAGCTTACGTAAAAGAACATTACCCGAATGG
AGTCTGCACTGTGTATGGCAAAAAAATAGATGGACAGCAAACCATTATTGCATGCATAGAAAGCCATCAGTTCCAAGCAAAAAATTTTTG
GAATGGTCGTTGGAGGTCAGAATGGAAGTTTACAATCACTCCTTCAACCACTCAAGTGGTTGGCATCTTGAAAATTCAGGTTCATTATTA
TGAAGATGGTAATGTTCAGCTAGTGAGTCATAAAGATATACAAGATTCCCTAACAGTGTCTAATGAAGTGCAAACAGCAAAAGAATTTAT
AAAGATTGTAGAAGCTGCAGAAAATGAATACCAGACTGCCATCAGTGAGAATTATCAGACAATGTCGGACACTACTTTCAAAGCCTTACG
TCGACAGTTGCCAGTTACACGCACTAAGATTGATTGGAACAAGATCCTTAGCTACAAGATTGGCAAAGAGATGCAGAATGCATAAGATGA
ACATTGCATGACCGGATCATTTTAGTGTCTTTGCGTTAAAAAATCATTGCAAAAGTATTCTGAACTGTCAAGCTGCCCAGTCAGATGGGC
TGTTGCCATTTAAAATCACTGTAATTAATTAGTTTGATTAGAGCACAAAGCTTAGCTAATCAACCATTATTTTTCATTTTGTTTGTTCTA
AGAGGATTGAAAATCAGTTTAGTTTAAATGTCTTTCTGTTAGGCCTTTCTTTCTTACAATGAAGAGATGATTCTTCTAGTTTATGGTTAA
AAGTTTTTGAAGTGTCTCAAAAATATTTTACTAACTGTAACCCTAAAATTGATGTCTTTTGGTTTATGAAATCAGTAATTTTTGATATTT
CCCCAGTTCTTTTTAATGGGGTCAATAATGGACATTCTAGTTTAAGGTGGTTGATGGATTTAGCCATATATGCTGCTAAAGAAATTGTCT
ACCTTTTCTTCCTCACCTGTTCCATTTATGTAAAGTTGAGATTAGAGGGAAAGCATTTTCTATATCAATTGTGTTTAAACCTTTCAAGAA
GGTTATTTAGCTAGCTTAGTGTTGAACTAAATTTTTTTTAAACAAGGCAAGGTCTAATGCTGTTTTGAGATTCTGAAATTAATGAAAATA
CTTATTTCAGAAATGCATTTAATGCTTTTTTTCTTGTGACAGTTACGCAAATCAGCTTGAATTCCATATGTCCCTGAGTTATTTTTATCA
TAAAGCCACAAATGTATTATAACAAGGCAAATTGTAATATATATAATCCTGAACTCATGACCATGTCTCGGTTTATTTTTTTTTTCTTGG
ATTGAAAAGTACTGAAATTCAATGTGACATTAAAATGCAAATTTTCCTATTTATTTGAGTAGAAAATCACTTACCAGTGAGCATATATAT
TTTAAAATACTTTCTTTGGATATTGTAATTCTTAACTGGTTGTAAATTAGAAAAGCTGGGATTACATATGGTGTGCGGTTACAGTCTAAA
TTTTTTCATCCTCCTATGCATCATAAGCATGTTTGTAATATTTTCAAAAATAGTTCTACTGATGCTACAGGAATTTCAAGCCTGTGGTGA
ATGTTAGTATTTACCATAGGGAGTGAAGTGGAGTTATGGTTTCATTCAATAGAGTATTGCTGATTATACTTGAGTGGAATCCTTTCCTCA
CGTACTCCCACAGACGTCTGGGCCTGGAAATTTTTTTTTTATTTTATTTTATTGTTTTTTTTTTTAGAAAAACACCACTTTTATTATGTA
CAATAAAATATTTCATTAGCTTGAATTGTATAGATTTTTAAAAATTCAATGAAAGCATGTTGTTTAATTTCTTTTTAAAATCACTGTTGG
GCTTTGAAAGCATTGAGAATATAATATGAAATTATGACATTTTGTCTAAATCATCTTTTCTTTAGTTTTAAAATACAAGTTTTGGCACAT
TGGGATTCCTAAAGAAAATGAATTGGTAACATTAATTATCTGTTCCTTTTTAAAATATATATATTTGAAAGTTTGATGATGGTGAACTAA
ATACTAGATCTAATTGACAAGCTTAGTTGTATCAGTTAGGCCATCATGAGTTTCTATCCCATGAAAGTCATCAATTTCCTATCTCTGTTC
TAGTCTGGAATGCATTACTGAAAATGTATGCAACTGTTTTTAAGGTGATTTGCTTGTGAGACGGAAGATTTATCAAAAATAATTTAGAAC
AGGCTGGGCGCGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGGGGTCAGGAGATTGAGACCACCCT
GACTAACACAGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGACAGGCGCTTGTAGTCCCAGCTACTCGGGAG
GCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTCGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCA
AGACTCTGTCTCAAAAAATAATAATAATAATAATAATAATATAATTTAGAACAGTCTGAAATAATGATGGCACAGAATAGTCTTTTATAG
TATAAGAATGGCATTTATTAGGCAGGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTC
AGGAGTTCGAGACCAGCCTGACCAACATGCTGAAACCCCGTCTCTACTAAAAACAAAAAAAAATTAGCCGGGGATGGTGATGCGCGCCTG
TAATCCCAACTACTCAGGAGGCTGAGACAGGAGAATCATTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCAGAGATCGAGCCACTGTACT
CCAGCCTGGGTGACACAGGGAGCCTCTGTCTCAAAATAATAATAATAATAAAAGAATGGCATTTATTAAAGTGAAAGAAGAATGGAAACC
CAGAGTATCCTATAGCTCAGGGATGTAATTTTAGTAGGAGACATTATGGCTGCTTTGCTGAGTAGGCTGAAGTGTGGTGGCAAAGGCATA
ATCAGGGAGAACAGCTAGGAGACTACTGCAGTAATCTAGTTGAGAGAGCATGCTGGCTTGGACTGAGGTGGTTGCTGTAGAGGTGGTATA
AAGCAGTGAGGTCTAGGTATATCCTAAAGGTAAAATCAGCAAGACCTGGGGAGAGTTTGGTCATGGAGTGTGAGATAAAGAGAACCATGT
CTGGGGCTGGAGAAATTGAGGAAGATTCTTGTAGGAGCAAGTTGGTTTGGAGAAGAAGGCTGGTCAGGAGCTCAGTTTTCTATTCAAAGG
AGAAATATCTCATGTAGCAGTTAGATACAGGAGACAGGAACTAGAGGAAAGCTCTGGGCTAGAAGAATGGGAAAGTGCATGAACCTGGAA
ACAATTTTATAGGCAGACAGGATGAAGGACCTCAAGGTTAGTGATAATGAATTTAAAGTAAATGAGACCAATGATGAGCATGGCTGTATG
TTTTTCTTCAACCGTGTAAAGCTGTTTGGGTGCAGGCATAGAGTAGATGAAATAAATTTCACCAGGGCTGTGGTTTTGCCCAGAGTGAAT
GACCACATGAAGAGGGGCAGGGTATGATGATGGTCTGTGGAATTTCAGCTGGGTAAGCAGGGAAGTGAGGGCTTGAGACGGGGGGAGGGA
TAGTGAAAATGTACAACCAGTGGATTATAGGTGTGTTAAAGTAGGGGAACTAGAAAGAATGACCTGGAAATGTAAGAAGTGGGCCGGGCG
CAGTGGCTCATGCCTGTAATCCCAGCACTTTAGGAGGCTGAGGTGGGTGGATCATGAGGTCCAGAGATCAAGACCATCCTGGCCAATATG
GTGCAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGTGCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGCAGGAG
AATCGCTTGAACCCAGGATGCGAAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGGCTGGCGACAGAGCGAGACTCTGTCCCAA
AAAAAAAAAAAAGTGGTGGGCTGGCCACGATGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCCACGGCAAGTGGATCATTTAAGGTC
AGGAGTTCAAGACCAGTCTGGCTAATATGATGAAACCCCTTCTGTATTAAAAATACAAATATTAGCCGGGCATGGTGGCACATGCCTGTA
GTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCTTTGAACCCAGGAAGTGACAGTTACAACGAGCGGAGACTGTGCCACTTCACTGCA
GCCTGGGTGACAGGGTGAGAGTCTGTCTCAAAAAAAGAAAAAGGAAATGTAAGAAGTGGTGATTGGAGAATGGTGTGCTTAATTAAAATT
GAGGTTTTGAGGAGTTACTAGTAATGACAAATATGACCAACGGAGTGACTGGCTGAGGGGAGAGAGGAGAGGACTTAAGCAACTGTGCCA
CTCAGCATTGGAAAGGTCACCTCTGTGACATTAAAATCAAGAATTCTGATAGAAGTAAGAGTTCTGGCATGAGTGGTGCTTTTCCAGAGT
ACACTTGGATATATGATTACATTTTAATAAGTTATATAAATATGCAGATATTCATGCGGCTTTTCCTCATTTGGGATTTTGGAAACTAAA

>94480_94480_1_TSC22D1-CAPZA2_TSC22D1_chr13_45147299_ENST00000458659_CAPZA2_chr7_116528181_ENST00000361183_length(amino acids)=973AA_BP=
MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGSGSASALNAAGTGVGSNATSSEDFPPPSLLQPPPPAASSTSGPQPPPPQSLNLLSQ
AQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNF
QEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASITGGPPSSPVSRKLSTTGSSDS
ITPVAPTSAVSSSGSPASVMTNMRAPSTTGGIGINSVTGTSTVNNVNITAVGSFNPNVTSSMLGNVNISTSNIPSAAGVSVGPGVTSGVN
VNILSGMGNGTISSSAAVSSVPNAAAGMTGGSVSSQQQQPTVNTSRFRVVKLDSSSEPFKKGRWTCTEFYEKENAVPATEGVLINKVVET
VKQNPIEVTSERESTSGSSVSSSVSTLSHYTESVGSGEMGAPTVVVQQQQQQQQQQQQQPALQGVTLQQMDFGSTGPQSIPAVSIPQSIS
QSQISQVQLQSQELSYQQKQGLQPVPLQATMSAATGIQPSPVNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYG
QQQPMVSTQMAPGHVKSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAVPAQPAGASVQPVGQAPAAV
SAVPTGSQIANIGQQANIPTAVQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQPQGVEPVA
QGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSAQ

--------------------------------------------------------------
>94480_94480_2_TSC22D1-CAPZA2_TSC22D1_chr13_45147299_ENST00000458659_CAPZA2_chr7_116528181_ENST00000458284_length(transcript)=4734nt_BP=3403nt
CCGGGGGTGGCGAGGGGAAGGCGACATTTGCTTGGCGCTGCCTCCGTGCAGAGCGGCCGGGAGGGCTTTGCAGCGGCCGCCGACGCGGCG
GGAGGAGGGGGCTGAGGCGGCTTCGGAGTTGGCCGGAGAAGGTGGGCATTTCTCGCTTTTCCTCCCCTTCCTGCGCTCTCCCCCTCCCTC
CTGCCCCGCACCCCACGTGAAGCAGAATATAAAGGGGGGTGTGAGGCTAGAGGGGAAAGTGAATGGCGAAGGACTGAAGGGATCCCCCCT
TCGGGTCCCCGGCCGCCCTGTTCACCCTCGTTCATCCTCCTTTCCGAAGCTCGCTCTCGAAGGCAGGAGCGACCGGCGCCTTTGGCTGAG
GAGGAGGAGAAGGAGGAATCGCGCCAGGCGGAGCGTCAGGTCCCGTTTTCCTCTCCGGCGTCTCCAATACAAAGATTACGGTGCAGAAGG
AAATTGCACTCGTCTCCTCCGCGCCCCCGGTACCCAACACAATGCACCAGCCGCCTGAGTCCACCGCCGCGGCCGCCGCCGCTGCAGACA
TTAGCGCTAGGAAGATGGCGCACCCGGCAATGTTCCCTCGAAGGGGCAGCGGTAGTGGCAGCGCCTCTGCTCTCAATGCAGCAGGTACCG
GCGTCGGTAGTAATGCCACATCTTCCGAGGATTTTCCGCCTCCGTCGCTGCTTCAGCCGCCGCCCCCTGCAGCATCTTCTACGTCGGGAC
CACAGCCTCCGCCTCCACAAAGCCTGAACCTCCTTTCGCAGGCTCAGCTGCAGGCACAGCCTCTTGCGCCAGGCGGAACTCAAATGAAAA
AGAAAAGTGGCTTCCAGATAACTAGCGTTACTCCTGCTCAGATCTCCGCTAGTATCAGCTCTAACAACAGTATAGCAGAGGACACTGAGA
GCTATGATGATCTGGATGAATCTCACACGGAAGATCTCTCTTCTTCGGAGATCCTTGATGTGTCACTTTCCAGGGCTACTGACTTAGGGG
AGCCCGAACGCAGCTCCTCAGAAGAGACCCTAAATAACTTCCAGGAAGCCGAGACACCTGGGGCAGTCTCTCCCAACCAGCCCCACCTTC
CTCAGCCTCATTTGCCTCACCTTCCACAACAGAATGTTGTGATCAATGGGAATGCTCATCCACACCACCTCCATCACCACCATCAGATTC
ATCATGGGCACCACCTCCAACATGGTCACCACCATCCATCTCATGTTGCTGTGGCCAGTGCATCCATTACTGGTGGGCCACCCTCAAGCC
CAGTATCTAGAAAACTCTCTACAACTGGAAGCTCTGACAGTATCACACCAGTTGCACCAACTTCTGCTGTATCATCCAGTGGTTCACCTG
CATCTGTAATGACTAATATGCGTGCTCCAAGTACTACAGGTGGAATAGGTATAAATTCTGTTACTGGCACTAGTACAGTAAATAATGTTA
ACATTACTGCTGTGGGTAGTTTTAATCCTAATGTGACAAGCAGCATGCTTGGTAATGTTAATATAAGTACAAGCAATATTCCTAGTGCTG
CTGGTGTGAGTGTTGGGCCTGGAGTTACCAGTGGTGTTAATGTGAATATCTTGAGTGGCATGGGCAATGGTACTATTTCTTCCTCTGCTG
CTGTTAGCAGTGTTCCTAATGCAGCTGCAGGGATGACTGGGGGATCGGTTTCAAGTCAGCAGCAACAACCAACAGTTAACACTTCGAGGT
TCAGAGTTGTGAAGTTAGATTCTAGTTCTGAGCCCTTTAAAAAAGGTAGATGGACTTGCACTGAGTTCTATGAAAAAGAAAATGCTGTAC
CTGCTACAGAAGGTGTGCTGATAAATAAAGTGGTGGAGACTGTAAAGCAAAATCCGATAGAAGTGACTTCTGAAAGGGAGAGCACTAGTG
GGAGTTCAGTGAGCAGTAGTGTCAGCACACTGAGTCACTATACAGAGAGTGTGGGAAGTGGAGAGATGGGAGCCCCTACTGTGGTGGTGC
AGCAGCAGCAGCAGCAACAACAACAACAACAGCAACAACCAGCTCTCCAAGGTGTGACCCTCCAACAGATGGATTTTGGTAGCACTGGTC
CACAGAGTATTCCAGCAGTTAGTATACCACAGAGTATTTCTCAGTCACAGATCTCACAAGTACAATTACAGTCTCAAGAACTGAGCTATC
AGCAAAAGCAAGGTCTTCAGCCAGTACCTCTGCAAGCCACTATGAGTGCTGCAACTGGTATCCAGCCATCGCCTGTAAATGTGGTTGGTG
TAACTTCAGCTTTAGGTCAGCAGCCTTCCATTTCCAGTTTGGCTCAACCCCAGCTACCATATTCTCAGGCGGCTCCTCCAGTGCAAACTC
CCCTTCCAGGGGCACCACCACCCCAACAGTTACAGTATGGACAACAGCAACCAATGGTTTCTACACAGATGGCCCCAGGCCATGTCAAAT
CAGTGACTCAAAATCCTGCTTCAGAGTATGTACAACAGCAGCCAATTCTTCAAACAGCAATGTCCTCCGGACAGCCCAGTTCTGCAGGAG
TAGGAGCAGGAACAACAGTGATTCCTGTGGCTCAGCCACAGGGTATCCAGCTGCCAGTGCAGCCCACAGCAGTCCCAGCACAACCTGCAG
GGGCATCTGTCCAGCCTGTTGGCCAGGCTCCGGCAGCAGTGTCTGCTGTACCTACTGGCAGTCAGATTGCAAATATTGGTCAGCAAGCAA
ACATACCTACTGCAGTGCAGCAGCCCTCTACCCAGGTTCCACCTTCAGTTATTCAGCAGGGTGCTCCTCCATCTTCGCAAGTGGTTCCAC
CTGCTCAAACTGGGATTATTCATCAGGGAGTTCAAACTAGTGCTCCAAGCCTTCCTCAACAATTGGTTATTGCATCCCAAAGTTCCTTGT
TAACTGTGCCTCCCCAGCCACAAGGAGTAGAACCAGTAGCTCAAGGAATTGTTTCACAGCAGTTGCCTGCAGTTAGTTCTTTGCCCTCTG
CTAGTAGTATTTCTGTTACAAGTCAGGTTAGTTCAACTGGTCCTTCTGGAATGCCTTCTGCCCCAACAAACTTGGTTCCACCACAAAATA
TAGCACAAACCCCTGCTACCCAAAATGGTAATTTGGTTCAAAGTGTTAGTCAACCTCCCTTGATAGCAACTAATACAAATTTGCCTTTGG
CACAACAGATACCACTAAGTTCTACCCAGTTCTCCGCACAATCATTAGCTCAGGCAATTGGAAGCCAAATTGAAGATGCCAGGCGTGCAG
CGGAGCCCTCCTTAGTTGGCTTACCTCAGACTATCAGTGGTGACAGTGGGGGAATGTCAGCAGTTTCAGATGGGAGTAGCAGCAGCCTAG
CAGCCTCTGCTTCTCTTTTCCCGTTGAAGGTGCTACCGCTGACGACACCCCTGGTGGATGGCGAGGATGAGAGGTGCGTATAGCAGCAAA
ATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTTCGGTTACTGCTTAATAATGACAATCTTCTCAGGGAAGG
AGCAGCCCATGCATTTGCACAGTATAACTTGGACCAGTTTACTCCAGTAAAAATTGAAGGTTATGAAGATCAGGTATTGATAACAGAACA
TGGCGACTTGGGAAATGGAAAGTTTTTGGATCCAAAGAACAGAATCTGTTTTAAATTTGATCACTTAAGGAAGGAGGCAACTGATCCAAG
ACCCTGTGAAGTAGAAAATGCAGTTGAATCATGGAGAACTTCAGTAGAAACTGCTCTGAGAGCTTACGTAAAAGAACATTACCCGAATGG
AGTCTGCACTGAATGGTCGTTGGAGGTCAGAATGGAAGTTTACAATCACTCCTTCAACCACTCAAGTGGTTGGCATCTTGAAAATTCAGG
TTCATTATTATGAAGATGGTAATGTTCAGCTAGTGAGTCATAAAGATATACAAGATTCCCTAACAGTGTCTAATGAAGTGCAAACAGCAA
AAGAATTTATAAAGATTGTAGAAGCTGCAGAAAATGAATACCAGACTGCCATCAGTGAGAATTATCAGACAATGTCGGACACTACTTTCA
AAGCCTTACGTCGACAGTTGCCAGTTACACGCACTAAGATTGATTGGAACAAGATCCTTAGCTACAAGATTGGCAAAGAGATGCAGAATG
CATAAGATGAACATTGCATGACCGGATCATTTTAGTGTCTTTGCGTTAAAAAATCATTGCAAAAGTATTCTGAACTGTCAAGCTGCCCAG
TCAGATGGGCTGTTGCCATTTAAAATCACTGTAATTAATTAGTTTGATTAGAGCACAAAGCTTAGCTAATCAACCATTATTTTTCATTTT
GTTTGTTCTAAGAGGATTGAAAATCAGTTTAGTTTAAATGTCTTTCTGTTAGGCCTTTCTTTCTTACAATGAAGAGATGATTCTTCTAGT
TTATGGTTAAAAGTTTTTGAAGTGTCTCAAAAATATTTTACTAACTGTAACCCTAAAATTGATGTCTTTTGGTTTATGAAATCAGTAATT
TTTGATATTTCCCCAGTTCTTTTTAATGGGGTCAATAATGGACATTCTAGTTTAAGGTGGTTGATGGATTTAGCCATATATGCTGCTAAA
GAAATTGTCTACCTTTTCTTCCTCACCTGTTCCATTTATGTAAAGTTGAGATTAGAGGGAAAGCATTTTCTATATCAATTGTGTTTAAAC

>94480_94480_2_TSC22D1-CAPZA2_TSC22D1_chr13_45147299_ENST00000458659_CAPZA2_chr7_116528181_ENST00000458284_length(amino acids)=973AA_BP=
MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGSGSASALNAAGTGVGSNATSSEDFPPPSLLQPPPPAASSTSGPQPPPPQSLNLLSQ
AQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNF
QEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASITGGPPSSPVSRKLSTTGSSDS
ITPVAPTSAVSSSGSPASVMTNMRAPSTTGGIGINSVTGTSTVNNVNITAVGSFNPNVTSSMLGNVNISTSNIPSAAGVSVGPGVTSGVN
VNILSGMGNGTISSSAAVSSVPNAAAGMTGGSVSSQQQQPTVNTSRFRVVKLDSSSEPFKKGRWTCTEFYEKENAVPATEGVLINKVVET
VKQNPIEVTSERESTSGSSVSSSVSTLSHYTESVGSGEMGAPTVVVQQQQQQQQQQQQQPALQGVTLQQMDFGSTGPQSIPAVSIPQSIS
QSQISQVQLQSQELSYQQKQGLQPVPLQATMSAATGIQPSPVNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYG
QQQPMVSTQMAPGHVKSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAVPAQPAGASVQPVGQAPAAV
SAVPTGSQIANIGQQANIPTAVQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQPQGVEPVA
QGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSAQ

--------------------------------------------------------------
>94480_94480_3_TSC22D1-CAPZA2_TSC22D1_chr13_45147299_ENST00000458659_CAPZA2_chr7_116528181_ENST00000490693_length(transcript)=4161nt_BP=3403nt
CCGGGGGTGGCGAGGGGAAGGCGACATTTGCTTGGCGCTGCCTCCGTGCAGAGCGGCCGGGAGGGCTTTGCAGCGGCCGCCGACGCGGCG
GGAGGAGGGGGCTGAGGCGGCTTCGGAGTTGGCCGGAGAAGGTGGGCATTTCTCGCTTTTCCTCCCCTTCCTGCGCTCTCCCCCTCCCTC
CTGCCCCGCACCCCACGTGAAGCAGAATATAAAGGGGGGTGTGAGGCTAGAGGGGAAAGTGAATGGCGAAGGACTGAAGGGATCCCCCCT
TCGGGTCCCCGGCCGCCCTGTTCACCCTCGTTCATCCTCCTTTCCGAAGCTCGCTCTCGAAGGCAGGAGCGACCGGCGCCTTTGGCTGAG
GAGGAGGAGAAGGAGGAATCGCGCCAGGCGGAGCGTCAGGTCCCGTTTTCCTCTCCGGCGTCTCCAATACAAAGATTACGGTGCAGAAGG
AAATTGCACTCGTCTCCTCCGCGCCCCCGGTACCCAACACAATGCACCAGCCGCCTGAGTCCACCGCCGCGGCCGCCGCCGCTGCAGACA
TTAGCGCTAGGAAGATGGCGCACCCGGCAATGTTCCCTCGAAGGGGCAGCGGTAGTGGCAGCGCCTCTGCTCTCAATGCAGCAGGTACCG
GCGTCGGTAGTAATGCCACATCTTCCGAGGATTTTCCGCCTCCGTCGCTGCTTCAGCCGCCGCCCCCTGCAGCATCTTCTACGTCGGGAC
CACAGCCTCCGCCTCCACAAAGCCTGAACCTCCTTTCGCAGGCTCAGCTGCAGGCACAGCCTCTTGCGCCAGGCGGAACTCAAATGAAAA
AGAAAAGTGGCTTCCAGATAACTAGCGTTACTCCTGCTCAGATCTCCGCTAGTATCAGCTCTAACAACAGTATAGCAGAGGACACTGAGA
GCTATGATGATCTGGATGAATCTCACACGGAAGATCTCTCTTCTTCGGAGATCCTTGATGTGTCACTTTCCAGGGCTACTGACTTAGGGG
AGCCCGAACGCAGCTCCTCAGAAGAGACCCTAAATAACTTCCAGGAAGCCGAGACACCTGGGGCAGTCTCTCCCAACCAGCCCCACCTTC
CTCAGCCTCATTTGCCTCACCTTCCACAACAGAATGTTGTGATCAATGGGAATGCTCATCCACACCACCTCCATCACCACCATCAGATTC
ATCATGGGCACCACCTCCAACATGGTCACCACCATCCATCTCATGTTGCTGTGGCCAGTGCATCCATTACTGGTGGGCCACCCTCAAGCC
CAGTATCTAGAAAACTCTCTACAACTGGAAGCTCTGACAGTATCACACCAGTTGCACCAACTTCTGCTGTATCATCCAGTGGTTCACCTG
CATCTGTAATGACTAATATGCGTGCTCCAAGTACTACAGGTGGAATAGGTATAAATTCTGTTACTGGCACTAGTACAGTAAATAATGTTA
ACATTACTGCTGTGGGTAGTTTTAATCCTAATGTGACAAGCAGCATGCTTGGTAATGTTAATATAAGTACAAGCAATATTCCTAGTGCTG
CTGGTGTGAGTGTTGGGCCTGGAGTTACCAGTGGTGTTAATGTGAATATCTTGAGTGGCATGGGCAATGGTACTATTTCTTCCTCTGCTG
CTGTTAGCAGTGTTCCTAATGCAGCTGCAGGGATGACTGGGGGATCGGTTTCAAGTCAGCAGCAACAACCAACAGTTAACACTTCGAGGT
TCAGAGTTGTGAAGTTAGATTCTAGTTCTGAGCCCTTTAAAAAAGGTAGATGGACTTGCACTGAGTTCTATGAAAAAGAAAATGCTGTAC
CTGCTACAGAAGGTGTGCTGATAAATAAAGTGGTGGAGACTGTAAAGCAAAATCCGATAGAAGTGACTTCTGAAAGGGAGAGCACTAGTG
GGAGTTCAGTGAGCAGTAGTGTCAGCACACTGAGTCACTATACAGAGAGTGTGGGAAGTGGAGAGATGGGAGCCCCTACTGTGGTGGTGC
AGCAGCAGCAGCAGCAACAACAACAACAACAGCAACAACCAGCTCTCCAAGGTGTGACCCTCCAACAGATGGATTTTGGTAGCACTGGTC
CACAGAGTATTCCAGCAGTTAGTATACCACAGAGTATTTCTCAGTCACAGATCTCACAAGTACAATTACAGTCTCAAGAACTGAGCTATC
AGCAAAAGCAAGGTCTTCAGCCAGTACCTCTGCAAGCCACTATGAGTGCTGCAACTGGTATCCAGCCATCGCCTGTAAATGTGGTTGGTG
TAACTTCAGCTTTAGGTCAGCAGCCTTCCATTTCCAGTTTGGCTCAACCCCAGCTACCATATTCTCAGGCGGCTCCTCCAGTGCAAACTC
CCCTTCCAGGGGCACCACCACCCCAACAGTTACAGTATGGACAACAGCAACCAATGGTTTCTACACAGATGGCCCCAGGCCATGTCAAAT
CAGTGACTCAAAATCCTGCTTCAGAGTATGTACAACAGCAGCCAATTCTTCAAACAGCAATGTCCTCCGGACAGCCCAGTTCTGCAGGAG
TAGGAGCAGGAACAACAGTGATTCCTGTGGCTCAGCCACAGGGTATCCAGCTGCCAGTGCAGCCCACAGCAGTCCCAGCACAACCTGCAG
GGGCATCTGTCCAGCCTGTTGGCCAGGCTCCGGCAGCAGTGTCTGCTGTACCTACTGGCAGTCAGATTGCAAATATTGGTCAGCAAGCAA
ACATACCTACTGCAGTGCAGCAGCCCTCTACCCAGGTTCCACCTTCAGTTATTCAGCAGGGTGCTCCTCCATCTTCGCAAGTGGTTCCAC
CTGCTCAAACTGGGATTATTCATCAGGGAGTTCAAACTAGTGCTCCAAGCCTTCCTCAACAATTGGTTATTGCATCCCAAAGTTCCTTGT
TAACTGTGCCTCCCCAGCCACAAGGAGTAGAACCAGTAGCTCAAGGAATTGTTTCACAGCAGTTGCCTGCAGTTAGTTCTTTGCCCTCTG
CTAGTAGTATTTCTGTTACAAGTCAGGTTAGTTCAACTGGTCCTTCTGGAATGCCTTCTGCCCCAACAAACTTGGTTCCACCACAAAATA
TAGCACAAACCCCTGCTACCCAAAATGGTAATTTGGTTCAAAGTGTTAGTCAACCTCCCTTGATAGCAACTAATACAAATTTGCCTTTGG
CACAACAGATACCACTAAGTTCTACCCAGTTCTCCGCACAATCATTAGCTCAGGCAATTGGAAGCCAAATTGAAGATGCCAGGCGTGCAG
CGGAGCCCTCCTTAGTTGGCTTACCTCAGACTATCAGTGGTGACAGTGGGGGAATGTCAGCAGTTTCAGATGGGAGTAGCAGCAGCCTAG
CAGCCTCTGCTTCTCTTTTCCCGTTGAAGGTGCTACCGCTGACGACACCCCTGGTGGATGGCGAGGATGAGAGGTGCGTATAGCAGCAAA
ATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTTCGGTTACTGCTTAATAATGACAATCTTCTCAGGGAAGG
AGCAGCCCATGCATTTGCACAGTATAACTTGGACCAGTTTACTCCAGTAAAAATTGAAGGTTATGAAGATCAGGTATTGATAACAGAACA
TGGCGACTTGGGAAATGGAAAGTTTTTGGATCCAAAGAACAGAATCTGTTTTAAATTTGATCACTTAAGGAAGGAGGCAACTGATCCAAG
ACCCTGTGAAGTAGAAAATGCAGTTGAATCATGGAGAACTTCAGTAGAAACTGCTCTGAGAGCTTACGTAAAAGAACATTACCCGAATGG
AGTCTGCACTGTAAGTCATCAGTAGCAGCTTTGTGTGTGTGTTTTGTGTAAATGTGAGTCTTTAGCGTCTCTTAAAATTTACAGTAACTT
ACAGAATTGACATTGTATAATTTGTCATTTTTTTCCTTAAATATTTCTAAGAATGTTTACTATTTTTTCAAGAAATTCTGGATAATAAAT
AGATATACTAGGATGGCTTAAAATAGAGAAATGGTTGTACCTTGATTTAAATCCATGTAGAAATTCTAATACATTGATTAAAGGAGCAGG
ATATGGTGAGATTCTGTAATCTTATGTTCATGACTCGTCTCAGTTTAGATCAAAGTTATTTTTATTAAGTCACAGAAATCTTAGAACAAA

>94480_94480_3_TSC22D1-CAPZA2_TSC22D1_chr13_45147299_ENST00000458659_CAPZA2_chr7_116528181_ENST00000490693_length(amino acids)=973AA_BP=
MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGSGSASALNAAGTGVGSNATSSEDFPPPSLLQPPPPAASSTSGPQPPPPQSLNLLSQ
AQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNF
QEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASITGGPPSSPVSRKLSTTGSSDS
ITPVAPTSAVSSSGSPASVMTNMRAPSTTGGIGINSVTGTSTVNNVNITAVGSFNPNVTSSMLGNVNISTSNIPSAAGVSVGPGVTSGVN
VNILSGMGNGTISSSAAVSSVPNAAAGMTGGSVSSQQQQPTVNTSRFRVVKLDSSSEPFKKGRWTCTEFYEKENAVPATEGVLINKVVET
VKQNPIEVTSERESTSGSSVSSSVSTLSHYTESVGSGEMGAPTVVVQQQQQQQQQQQQQPALQGVTLQQMDFGSTGPQSIPAVSIPQSIS
QSQISQVQLQSQELSYQQKQGLQPVPLQATMSAATGIQPSPVNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYG
QQQPMVSTQMAPGHVKSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAVPAQPAGASVQPVGQAPAAV
SAVPTGSQIANIGQQANIPTAVQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQPQGVEPVA
QGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSAQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TSC22D1-CAPZA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TSC22D1-CAPZA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TSC22D1-CAPZA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource