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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TSC2-RBP1 (FusionGDB2 ID:94521)

Fusion Gene Summary for TSC2-RBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TSC2-RBP1
Fusion gene ID: 94521
HgeneTgene
Gene symbol

TSC2

RBP1

Gene ID

7249

5947

Gene nameTSC complex subunit 2retinol binding protein 1
SynonymsLAM|PPP1R160|TSC4CRABP-I|CRBP|CRBP1|CRBPI|RBPC
Cytomap

16p13.3

3q23

Type of geneprotein-codingprotein-coding
Descriptiontuberinprotein phosphatase 1, regulatory subunit 160tuberous sclerosis 2 proteinretinol-binding protein 1CRBP-Icellular retinol binding protein 1cellular retinol-binding protein Iretinol-binding protein 1, cellular
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000219476, ENST00000350773, 
ENST00000353929, ENST00000382538, 
ENST00000401874, ENST00000439673, 
ENST00000568454, ENST00000568366, 
ENST00000483943, ENST00000492918, 
ENST00000232219, 
Fusion gene scores* DoF score10 X 12 X 6=7204 X 3 X 3=36
# samples 126
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TSC2 [Title/Abstract] AND RBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSC2(2108874)-RBP1(139258671), # samples:1
TSC2(2108874)-RBP1(139258674), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TSC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1552-01ATSC2chr16

2108874

+RBP1chr3

139258674

-
ChimerDB4OVTCGA-24-1552TSC2chr16

2108874

+RBP1chr3

139258671

-


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Fusion Gene ORF analysis for TSC2-RBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000219476ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000219476ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000219476ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000219476ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000350773ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000350773ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000350773ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000350773ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000353929ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000353929ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000353929ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000353929ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000382538ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000382538ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000382538ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000382538ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000401874ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000401874ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000401874ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000401874ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000439673ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000439673ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000439673ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000439673ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000568454ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000568454ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258671

-
5CDS-intronENST00000568454ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258674

-
5CDS-intronENST00000568454ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258671

-
In-frameENST00000219476ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258674

-
In-frameENST00000219476ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258671

-
In-frameENST00000350773ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258674

-
In-frameENST00000350773ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258671

-
In-frameENST00000353929ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258674

-
In-frameENST00000353929ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258671

-
In-frameENST00000382538ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258674

-
In-frameENST00000382538ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258671

-
In-frameENST00000401874ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258674

-
In-frameENST00000401874ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258671

-
In-frameENST00000439673ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258674

-
In-frameENST00000439673ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258671

-
In-frameENST00000568454ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258674

-
In-frameENST00000568454ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258671

-
intron-3CDSENST00000568366ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258674

-
intron-3CDSENST00000568366ENST00000232219TSC2chr16

2108874

+RBP1chr3

139258671

-
intron-intronENST00000568366ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258674

-
intron-intronENST00000568366ENST00000483943TSC2chr16

2108874

+RBP1chr3

139258671

-
intron-intronENST00000568366ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258674

-
intron-intronENST00000568366ENST00000492918TSC2chr16

2108874

+RBP1chr3

139258671

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000219476TSC2chr162108874+ENST00000232219RBP1chr3139258671-25031605572309750
ENST00000382538TSC2chr162108874+ENST00000232219RBP1chr3139258671-1821923891627512
ENST00000401874TSC2chr162108874+ENST00000232219RBP1chr3139258671-197910811061785559
ENST00000353929TSC2chr162108874+ENST00000232219RBP1chr3139258671-197910811061785559
ENST00000439673TSC2chr162108874+ENST00000232219RBP1chr3139258671-1843945811649522
ENST00000350773TSC2chr162108874+ENST00000232219RBP1chr3139258671-19481050751754559
ENST00000568454TSC2chr162108874+ENST00000232219RBP1chr3139258671-19741076591780573
ENST00000219476TSC2chr162108874+ENST00000232219RBP1chr3139258674-25031605572309750
ENST00000382538TSC2chr162108874+ENST00000232219RBP1chr3139258674-1821923891627512
ENST00000401874TSC2chr162108874+ENST00000232219RBP1chr3139258674-197910811061785559
ENST00000353929TSC2chr162108874+ENST00000232219RBP1chr3139258674-197910811061785559
ENST00000439673TSC2chr162108874+ENST00000232219RBP1chr3139258674-1843945811649522
ENST00000350773TSC2chr162108874+ENST00000232219RBP1chr3139258674-19481050751754559
ENST00000568454TSC2chr162108874+ENST00000232219RBP1chr3139258674-19741076591780573

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000219476ENST00000232219TSC2chr162108874+RBP1chr3139258671-0.029652120.9703479
ENST00000382538ENST00000232219TSC2chr162108874+RBP1chr3139258671-0.005794620.9942054
ENST00000401874ENST00000232219TSC2chr162108874+RBP1chr3139258671-0.0083987380.9916013
ENST00000353929ENST00000232219TSC2chr162108874+RBP1chr3139258671-0.0083987380.9916013
ENST00000439673ENST00000232219TSC2chr162108874+RBP1chr3139258671-0.0081263960.99187356
ENST00000350773ENST00000232219TSC2chr162108874+RBP1chr3139258671-0.0089880960.991012
ENST00000568454ENST00000232219TSC2chr162108874+RBP1chr3139258671-0.0074460960.9925539
ENST00000219476ENST00000232219TSC2chr162108874+RBP1chr3139258674-0.029652120.9703479
ENST00000382538ENST00000232219TSC2chr162108874+RBP1chr3139258674-0.005794620.9942054
ENST00000401874ENST00000232219TSC2chr162108874+RBP1chr3139258674-0.0083987380.9916013
ENST00000353929ENST00000232219TSC2chr162108874+RBP1chr3139258674-0.0083987380.9916013
ENST00000439673ENST00000232219TSC2chr162108874+RBP1chr3139258674-0.0081263960.99187356
ENST00000350773ENST00000232219TSC2chr162108874+RBP1chr3139258674-0.0089880960.991012
ENST00000568454ENST00000232219TSC2chr162108874+RBP1chr3139258674-0.0074460960.9925539

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Fusion Genomic Features for TSC2-RBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSC2-RBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:2108874/chr3:139258671)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSC2chr16:2108874chr3:139258671ENST00000219476+10421531_17583251808.0DomainRap-GAP
HgeneTSC2chr16:2108874chr3:139258671ENST00000350773+10411531_17583251785.0DomainRap-GAP
HgeneTSC2chr16:2108874chr3:139258671ENST00000353929+10411531_17583251765.0DomainRap-GAP
HgeneTSC2chr16:2108874chr3:139258671ENST00000401874+10401531_17583251741.0DomainRap-GAP
HgeneTSC2chr16:2108874chr3:139258671ENST00000439673+9391531_17582881705.0DomainRap-GAP
HgeneTSC2chr16:2108874chr3:139258674ENST00000219476+10421531_17583251808.0DomainRap-GAP
HgeneTSC2chr16:2108874chr3:139258674ENST00000350773+10411531_17583251785.0DomainRap-GAP
HgeneTSC2chr16:2108874chr3:139258674ENST00000353929+10411531_17583251765.0DomainRap-GAP
HgeneTSC2chr16:2108874chr3:139258674ENST00000401874+10401531_17583251741.0DomainRap-GAP
HgeneTSC2chr16:2108874chr3:139258674ENST00000439673+9391531_17582881705.0DomainRap-GAP


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Fusion Gene Sequence for TSC2-RBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94521_94521_1_TSC2-RBP1_TSC2_chr16_2108874_ENST00000219476_RBP1_chr3_139258671_ENST00000232219_length(transcript)=2503nt_BP=1605nt
CGTTTTCTTGCTTGGGGCGAAAGGGGGCAGCGGAGCGGAGCGCCCGAAACCCAGCCCCTGCGGACCGCAATCTTTGGGAAAAAGGCGCAA
GGTGGGAACGCAGGGCCGCACGTGGGAACCGTTCGCGGCTGCCGGGTTTGCAGCCCCTGCCCGCGCAGCTGGGAGCCGCAGGAGGCGGCC
CGGGACTCCAGCCTGCAGCCCCTATCCCGCCTCCTCCCACGCTCCAGCCACGGCGCGGCGCTACCTGCTGCAGCCTCTCTTCTCCGGAGA
GGCCCGGGCTCCTCCCTACACCCCCGCGGCCCAGCCCCGGGTCCCAGGCTCCGGCTCCGGGTCAGCATCCTCGCGCTCAAGGCGGTCATG
CCGGACTCCTGCGGACTACACATCCCGGCGGCCCATGCGGCCCCGTCACGTGATGCAAGGATCGCCGGCCTTTCCGCCAGAGGGCGGCAC
AGAACTACAACTCCCAGCAAGCTCCCAAGGCGGCCCTCCGCGCAATGCCGCTACCGGAAGTGCGGGTCGCGCTTCCGGCGGCGTCCCGGG
GCCAGGGGGGTGCGCCTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGAGGGGTTTTCTGGTGCGTCCTGGTCCACC
ATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAAATCCCAGGTCT
GCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATG
ATAGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGTCGCGGATCTGTTGCAG
CCGGAGCGGCCGCTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCGTTTGGGGGTCCTCAGA
GCCCTCTTCTTTAAGGTCATCAAGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGG
AGACACATCACCTACTTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTG
GTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCG
TCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATC
GTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGGCACCCACCTGGGCCAC
AGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGCCGTGTTTTTTGTGGGC
ATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGAAACGAACTGAACGT
CTGAAACGAAGGTGGCGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAAGCGGGGAGGAGCGACC
GCTACAATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTCCCCGGAGGGCGCTCAT
TTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGTGGCCAACTGGCTCCAG
TCACTCCCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCTGCGCGCCCTCGACGTC
AATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGATCATCCGCACGCTGAGC
ACTTTTAGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCGCAAGTGCATGACAACA
GTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTG
CACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAA
TCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTG

>94521_94521_1_TSC2-RBP1_TSC2_chr16_2108874_ENST00000219476_RBP1_chr3_139258671_ENST00000232219_length(amino acids)=750AA_BP=516
MRTAIFGKKAQGGNAGPHVGTVRGCRVCSPCPRSWEPQEAARDSSLQPLSRLLPRSSHGAALPAAASLLRRGPGSSLHPRGPAPGPRLRL
RVSILALKAVMPDSCGLHIPAAHAAPSRDARIAGLSARGRHRTTTPSKLPRRPSAQCRYRKCGSRFRRRPGARGVRLSPRRGGPERGGAA
REGFSGASWSTMAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVE
ALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMD
VGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKL
MRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTSPAP
APALAKRGGATATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNE
NFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGR

--------------------------------------------------------------
>94521_94521_2_TSC2-RBP1_TSC2_chr16_2108874_ENST00000219476_RBP1_chr3_139258674_ENST00000232219_length(transcript)=2503nt_BP=1605nt
CGTTTTCTTGCTTGGGGCGAAAGGGGGCAGCGGAGCGGAGCGCCCGAAACCCAGCCCCTGCGGACCGCAATCTTTGGGAAAAAGGCGCAA
GGTGGGAACGCAGGGCCGCACGTGGGAACCGTTCGCGGCTGCCGGGTTTGCAGCCCCTGCCCGCGCAGCTGGGAGCCGCAGGAGGCGGCC
CGGGACTCCAGCCTGCAGCCCCTATCCCGCCTCCTCCCACGCTCCAGCCACGGCGCGGCGCTACCTGCTGCAGCCTCTCTTCTCCGGAGA
GGCCCGGGCTCCTCCCTACACCCCCGCGGCCCAGCCCCGGGTCCCAGGCTCCGGCTCCGGGTCAGCATCCTCGCGCTCAAGGCGGTCATG
CCGGACTCCTGCGGACTACACATCCCGGCGGCCCATGCGGCCCCGTCACGTGATGCAAGGATCGCCGGCCTTTCCGCCAGAGGGCGGCAC
AGAACTACAACTCCCAGCAAGCTCCCAAGGCGGCCCTCCGCGCAATGCCGCTACCGGAAGTGCGGGTCGCGCTTCCGGCGGCGTCCCGGG
GCCAGGGGGGTGCGCCTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGAGGGGTTTTCTGGTGCGTCCTGGTCCACC
ATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAAATCCCAGGTCT
GCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATG
ATAGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGTCGCGGATCTGTTGCAG
CCGGAGCGGCCGCTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCGTTTGGGGGTCCTCAGA
GCCCTCTTCTTTAAGGTCATCAAGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGG
AGACACATCACCTACTTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTG
GTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCG
TCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATC
GTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGGCACCCACCTGGGCCAC
AGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGCCGTGTTTTTTGTGGGC
ATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGAAACGAACTGAACGT
CTGAAACGAAGGTGGCGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAAGCGGGGAGGAGCGACC
GCTACAATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTCCCCGGAGGGCGCTCAT
TTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGTGGCCAACTGGCTCCAG
TCACTCCCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCTGCGCGCCCTCGACGTC
AATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGATCATCCGCACGCTGAGC
ACTTTTAGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCGCAAGTGCATGACAACA
GTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTG
CACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAA
TCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTG

>94521_94521_2_TSC2-RBP1_TSC2_chr16_2108874_ENST00000219476_RBP1_chr3_139258674_ENST00000232219_length(amino acids)=750AA_BP=516
MRTAIFGKKAQGGNAGPHVGTVRGCRVCSPCPRSWEPQEAARDSSLQPLSRLLPRSSHGAALPAAASLLRRGPGSSLHPRGPAPGPRLRL
RVSILALKAVMPDSCGLHIPAAHAAPSRDARIAGLSARGRHRTTTPSKLPRRPSAQCRYRKCGSRFRRRPGARGVRLSPRRGGPERGGAA
REGFSGASWSTMAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVE
ALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMD
VGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKL
MRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTSPAP
APALAKRGGATATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNE
NFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGR

--------------------------------------------------------------
>94521_94521_3_TSC2-RBP1_TSC2_chr16_2108874_ENST00000350773_RBP1_chr3_139258671_ENST00000232219_length(transcript)=1948nt_BP=1050nt
CTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGAGGGGTTTTCTGGTGCGTCCTGGTCCACCATGGCCAAACCAACA
AGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAAATCCCAGGTCTGCAGAGGGTAAACAG
ACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATGATAGGGCAGATTTGT
GAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGTCGCGGATCTGTTGCAGCCGGAGCGGCCGCTG
GAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCGTTTGGGGGTCCTCAGAGCCCTCTTCTTTAAG
GTCATCAAGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGGAGACACATCACCTAC
TTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTGGTGAACTTGGTCAAA
TTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCGTCCTCTGTGGACATA
GAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATCGTTACCCTCTGTCGC
ACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGGCACCCACCTGGGCCACAGCGCCATCTACAAC
ATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGCCGTGTTTTTTGTGGGCATGGCTCTCTGGGGA
GCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGAAACGAACTGAACGTCTGAAACGAAGGTGG
CGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAAGCGGGGAGGAGCGACCGCTACAATGGATCCT
CCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTCCCCGGAGGGCGCTCATTTCCGGGCCGCCCAC
CACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGTGGCCAACTGGCTCCAGTCACTCCCCGAAATG
CCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCTGCGCGCCCTCGACGTCAATGTGGCCTTGCGC
AAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGATCATCCGCACGCTGAGCACTTTTAGGAACTAC
ATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCGCAAGTGCATGACAACAGTGAGCTGGGACGGA
GACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGCACCTGGAGATGAGA
GTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAATCAGCAGGATGTGTG
GGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGTCTCTTGGCTTTGTC

>94521_94521_3_TSC2-RBP1_TSC2_chr16_2108874_ENST00000350773_RBP1_chr3_139258671_ENST00000232219_length(amino acids)=559AA_BP=325
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQ
PERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGH
SAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTSPAPAPALAKRGGAT
ATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDV
NVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDEL

--------------------------------------------------------------
>94521_94521_4_TSC2-RBP1_TSC2_chr16_2108874_ENST00000350773_RBP1_chr3_139258674_ENST00000232219_length(transcript)=1948nt_BP=1050nt
CTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGAGGGGTTTTCTGGTGCGTCCTGGTCCACCATGGCCAAACCAACA
AGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAAATCCCAGGTCTGCAGAGGGTAAACAG
ACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATGATAGGGCAGATTTGT
GAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGTCGCGGATCTGTTGCAGCCGGAGCGGCCGCTG
GAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCGTTTGGGGGTCCTCAGAGCCCTCTTCTTTAAG
GTCATCAAGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGGAGACACATCACCTAC
TTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTGGTGAACTTGGTCAAA
TTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCGTCCTCTGTGGACATA
GAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATCGTTACCCTCTGTCGC
ACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGGCACCCACCTGGGCCACAGCGCCATCTACAAC
ATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGCCGTGTTTTTTGTGGGCATGGCTCTCTGGGGA
GCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGAAACGAACTGAACGTCTGAAACGAAGGTGG
CGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAAGCGGGGAGGAGCGACCGCTACAATGGATCCT
CCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTCCCCGGAGGGCGCTCATTTCCGGGCCGCCCAC
CACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGTGGCCAACTGGCTCCAGTCACTCCCCGAAATG
CCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCTGCGCGCCCTCGACGTCAATGTGGCCTTGCGC
AAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGATCATCCGCACGCTGAGCACTTTTAGGAACTAC
ATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCGCAAGTGCATGACAACAGTGAGCTGGGACGGA
GACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGCACCTGGAGATGAGA
GTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAATCAGCAGGATGTGTG
GGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGTCTCTTGGCTTTGTC

>94521_94521_4_TSC2-RBP1_TSC2_chr16_2108874_ENST00000350773_RBP1_chr3_139258674_ENST00000232219_length(amino acids)=559AA_BP=325
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQ
PERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGH
SAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTSPAPAPALAKRGGAT
ATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDV
NVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDEL

--------------------------------------------------------------
>94521_94521_5_TSC2-RBP1_TSC2_chr16_2108874_ENST00000353929_RBP1_chr3_139258671_ENST00000232219_length(transcript)=1979nt_BP=1081nt
CCGGCGGCGTCCCGGGGCCAGGGGGGTGCGCCTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGAGGGGTTTTCTGG
TGCGTCCTGGTCCACCATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAG
GCCAAATCCCAGGTCTGCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAA
CAATCGCATCCGGATGATAGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGT
CGCGGATCTGTTGCAGCCGGAGCGGCCGCTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCG
TTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCAAGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGC
CCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGA
ATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCT
GTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAG
CCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGG
CACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGC
CGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCA
GAAACGAACTGAACGTCTGAAACGAAGGTGGCGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAA
GCGGGGAGGAGCGACCGCTACAATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTC
CCCGGAGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGT
GGCCAACTGGCTCCAGTCACTCCCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCT
GCGCGCCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGAT
CATCCGCACGCTGAGCACTTTTAGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCG
CAAGTGCATGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGAT
CGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACA
ACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCAT

>94521_94521_5_TSC2-RBP1_TSC2_chr16_2108874_ENST00000353929_RBP1_chr3_139258671_ENST00000232219_length(amino acids)=559AA_BP=325
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQ
PERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGH
SAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTSPAPAPALAKRGGAT
ATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDV
NVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDEL

--------------------------------------------------------------
>94521_94521_6_TSC2-RBP1_TSC2_chr16_2108874_ENST00000353929_RBP1_chr3_139258674_ENST00000232219_length(transcript)=1979nt_BP=1081nt
CCGGCGGCGTCCCGGGGCCAGGGGGGTGCGCCTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGAGGGGTTTTCTGG
TGCGTCCTGGTCCACCATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAG
GCCAAATCCCAGGTCTGCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAA
CAATCGCATCCGGATGATAGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGT
CGCGGATCTGTTGCAGCCGGAGCGGCCGCTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCG
TTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCAAGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGC
CCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGA
ATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCT
GTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAG
CCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGG
CACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGC
CGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCA
GAAACGAACTGAACGTCTGAAACGAAGGTGGCGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAA
GCGGGGAGGAGCGACCGCTACAATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTC
CCCGGAGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGT
GGCCAACTGGCTCCAGTCACTCCCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCT
GCGCGCCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGAT
CATCCGCACGCTGAGCACTTTTAGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCG
CAAGTGCATGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGAT
CGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACA
ACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCAT

>94521_94521_6_TSC2-RBP1_TSC2_chr16_2108874_ENST00000353929_RBP1_chr3_139258674_ENST00000232219_length(amino acids)=559AA_BP=325
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQ
PERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGH
SAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTSPAPAPALAKRGGAT
ATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDV
NVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDEL

--------------------------------------------------------------
>94521_94521_7_TSC2-RBP1_TSC2_chr16_2108874_ENST00000382538_RBP1_chr3_139258671_ENST00000232219_length(transcript)=1821nt_BP=923nt
GTCGCGCTTCCGGCGGCGTCCCGGGGCCAGGGGGGTGCGCCTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGGAAC
TGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATGATAGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAG
TGGAAGCACTCTGGAAGGCGGTCGCGGATCTGTTGCAGCCGGAGCGGCCGCTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCA
TCGTGCAGGGGCAGGGCGAGCGTTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCAAGGATTACCCTTCCAACGAAGACCTTCACG
AAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGA
TGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGA
TGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCT
ACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGA
AGCTGATGCGGAACCTCCTTGGCACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGG
ACGCGCCCCTGCTGAGAGGAGCCGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACAT
CTGTGTTGCCATCATTTTACCAGAAACGAACTGAACGTCTGAAACGAAGGTGGCGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCG
CCCCTGCGCCCGCCCTCGCTAAGCGGGGAGGAGCGACCGCTACAATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCG
CCGCCCCGCAGAGCCCCCTGTCCCCGGAGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTC
TCCAGCCGTCCCGCCCGCTTGTGGCCAACTGGCTCCAGTCACTCCCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCA
ACGAGAATTTCGAGGAGTACCTGCGCGCCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCG
TGCAGGACGGTGACCATATGATCATCCGCACGCTGAGCACTTTTAGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGG
ATCTGACAGGCATAGATGACCGCAAGTGCATGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGG
GGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGG
TGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAA
ATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGTCTCTTGGCTTTGTCACTTTTCCTTTTCTTAAAACAAAGCCATGCCAATAAA

>94521_94521_7_TSC2-RBP1_TSC2_chr16_2108874_ENST00000382538_RBP1_chr3_139258671_ENST00000232219_length(amino acids)=512AA_BP=278
MSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLH
ERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVC
YNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPT
SVLPSFYQKRTERLKRRWRGLDKPDPSTSPAPAPALAKRGGATATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGS
LQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEE

--------------------------------------------------------------
>94521_94521_8_TSC2-RBP1_TSC2_chr16_2108874_ENST00000382538_RBP1_chr3_139258674_ENST00000232219_length(transcript)=1821nt_BP=923nt
GTCGCGCTTCCGGCGGCGTCCCGGGGCCAGGGGGGTGCGCCTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGGAAC
TGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATGATAGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAG
TGGAAGCACTCTGGAAGGCGGTCGCGGATCTGTTGCAGCCGGAGCGGCCGCTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCA
TCGTGCAGGGGCAGGGCGAGCGTTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCAAGGATTACCCTTCCAACGAAGACCTTCACG
AAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGA
TGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGA
TGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCT
ACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGA
AGCTGATGCGGAACCTCCTTGGCACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGG
ACGCGCCCCTGCTGAGAGGAGCCGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACAT
CTGTGTTGCCATCATTTTACCAGAAACGAACTGAACGTCTGAAACGAAGGTGGCGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCG
CCCCTGCGCCCGCCCTCGCTAAGCGGGGAGGAGCGACCGCTACAATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCG
CCGCCCCGCAGAGCCCCCTGTCCCCGGAGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTC
TCCAGCCGTCCCGCCCGCTTGTGGCCAACTGGCTCCAGTCACTCCCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCA
ACGAGAATTTCGAGGAGTACCTGCGCGCCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCG
TGCAGGACGGTGACCATATGATCATCCGCACGCTGAGCACTTTTAGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGG
ATCTGACAGGCATAGATGACCGCAAGTGCATGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGG
GGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGG
TGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAA
ATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGTCTCTTGGCTTTGTCACTTTTCCTTTTCTTAAAACAAAGCCATGCCAATAAA

>94521_94521_8_TSC2-RBP1_TSC2_chr16_2108874_ENST00000382538_RBP1_chr3_139258674_ENST00000232219_length(amino acids)=512AA_BP=278
MSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLH
ERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVC
YNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPT
SVLPSFYQKRTERLKRRWRGLDKPDPSTSPAPAPALAKRGGATATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGS
LQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEE

--------------------------------------------------------------
>94521_94521_9_TSC2-RBP1_TSC2_chr16_2108874_ENST00000401874_RBP1_chr3_139258671_ENST00000232219_length(transcript)=1979nt_BP=1081nt
CCGGCGGCGTCCCGGGGCCAGGGGGGTGCGCCTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGAGGGGTTTTCTGG
TGCGTCCTGGTCCACCATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAG
GCCAAATCCCAGGTCTGCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAA
CAATCGCATCCGGATGATAGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGT
CGCGGATCTGTTGCAGCCGGAGCGGCCGCTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCG
TTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCAAGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGC
CCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGA
ATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCT
GTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAG
CCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGG
CACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGC
CGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCA
GAAACGAACTGAACGTCTGAAACGAAGGTGGCGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAA
GCGGGGAGGAGCGACCGCTACAATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTC
CCCGGAGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGT
GGCCAACTGGCTCCAGTCACTCCCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCT
GCGCGCCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGAT
CATCCGCACGCTGAGCACTTTTAGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCG
CAAGTGCATGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGAT
CGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACA
ACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCAT

>94521_94521_9_TSC2-RBP1_TSC2_chr16_2108874_ENST00000401874_RBP1_chr3_139258671_ENST00000232219_length(amino acids)=559AA_BP=325
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQ
PERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGH
SAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTSPAPAPALAKRGGAT
ATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDV
NVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDEL

--------------------------------------------------------------
>94521_94521_10_TSC2-RBP1_TSC2_chr16_2108874_ENST00000401874_RBP1_chr3_139258674_ENST00000232219_length(transcript)=1979nt_BP=1081nt
CCGGCGGCGTCCCGGGGCCAGGGGGGTGCGCCTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGAGGGGTTTTCTGG
TGCGTCCTGGTCCACCATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAG
GCCAAATCCCAGGTCTGCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAA
CAATCGCATCCGGATGATAGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGT
CGCGGATCTGTTGCAGCCGGAGCGGCCGCTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCG
TTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCAAGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGC
CCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGA
ATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCT
GTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAG
CCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGG
CACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGC
CGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCA
GAAACGAACTGAACGTCTGAAACGAAGGTGGCGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAA
GCGGGGAGGAGCGACCGCTACAATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTC
CCCGGAGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGT
GGCCAACTGGCTCCAGTCACTCCCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCT
GCGCGCCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGAT
CATCCGCACGCTGAGCACTTTTAGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCG
CAAGTGCATGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGAT
CGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACA
ACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCAT

>94521_94521_10_TSC2-RBP1_TSC2_chr16_2108874_ENST00000401874_RBP1_chr3_139258674_ENST00000232219_length(amino acids)=559AA_BP=325
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQ
PERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGH
SAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTSPAPAPALAKRGGAT
ATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDV
NVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDEL

--------------------------------------------------------------
>94521_94521_11_TSC2-RBP1_TSC2_chr16_2108874_ENST00000439673_RBP1_chr3_139258671_ENST00000232219_length(transcript)=1843nt_BP=945nt
GTGCGCCTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGAGGGGTTTTCTGGTGCGTCCTGGTCCACCATGGCCAAA
CCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAAATCCCAGGTCTGCAGAGGGT
AAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATGATAGGGCAG
ATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGGGCGAGCGTTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCAAGGATTAC
CCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTG
GCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTAC
CTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAG
GTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAG
GAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGGCACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATG
GAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGCCGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTAT
TCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGAAACGAACTGAACGTCTGAAACGAAGGTGGCGCGGCCTGGACAAA
CCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAAGCGGGGAGGAGCGACCGCTACAATGGATCCTCCCGCAGGCTTTGTG
CGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTCCCCGGAGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACC
GGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGTGGCCAACTGGCTCCAGTCACTCCCCGAAATGCCAGTCGACTTCACT
GGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCTGCGCGCCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTG
CTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGATCATCCGCACGCTGAGCACTTTTAGGAACTACATCATGGACTTCCAG
GTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCGCAAGTGCATGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGT
GTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTC
TGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCT
CTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGTCTCTTGGCTTTGTCACTTTTCCTTTTCTT

>94521_94521_11_TSC2-RBP1_TSC2_chr16_2108874_ENST00000439673_RBP1_chr3_139258671_ENST00000232219_length(amino acids)=522AA_BP=288
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEGERLGVLRALFFKVI
KDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEV
SLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAH
RLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTSPAPAPALAKRGGATATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHP
RSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIM

--------------------------------------------------------------
>94521_94521_12_TSC2-RBP1_TSC2_chr16_2108874_ENST00000439673_RBP1_chr3_139258674_ENST00000232219_length(transcript)=1843nt_BP=945nt
GTGCGCCTTTCTCCGCGTCGGGGCGGCCCGGAGCGCGGTGGCGCGGCGCGGGAGGGGTTTTCTGGTGCGTCCTGGTCCACCATGGCCAAA
CCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAAATCCCAGGTCTGCAGAGGGT
AAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATGATAGGGCAG
ATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGGGCGAGCGTTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCAAGGATTAC
CCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTG
GCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTAC
CTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAG
GTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAG
GAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGGCACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATG
GAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGCCGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTAT
TCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGAAACGAACTGAACGTCTGAAACGAAGGTGGCGCGGCCTGGACAAA
CCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAAGCGGGGAGGAGCGACCGCTACAATGGATCCTCCCGCAGGCTTTGTG
CGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTCCCCGGAGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACC
GGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGTGGCCAACTGGCTCCAGTCACTCCCCGAAATGCCAGTCGACTTCACT
GGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCTGCGCGCCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTG
CTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGATCATCCGCACGCTGAGCACTTTTAGGAACTACATCATGGACTTCCAG
GTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCGCAAGTGCATGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGT
GTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTC
TGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCT
CTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGTCTCTTGGCTTTGTCACTTTTCCTTTTCTT

>94521_94521_12_TSC2-RBP1_TSC2_chr16_2108874_ENST00000439673_RBP1_chr3_139258674_ENST00000232219_length(amino acids)=522AA_BP=288
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEGERLGVLRALFFKVI
KDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEV
SLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAH
RLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTSPAPAPALAKRGGATATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHP
RSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIM

--------------------------------------------------------------
>94521_94521_13_TSC2-RBP1_TSC2_chr16_2108874_ENST00000568454_RBP1_chr3_139258671_ENST00000232219_length(transcript)=1974nt_BP=1076nt
AGTTTTAAGTCATGGCGGGTGCGAACGGGTCTCTGCTGCAGGCGGCTCCGTGACAGCTCCTGCTTCACATGGAGGGGTTTTCTGGTGCGT
CCTGGTCCACCATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAA
ATCCCAGGTCTGCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATC
GCATCCGGATGATAGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGTCGCGG
ATCTGTTGCAGCCGGAGCGGCCGCTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCGTTTGG
GGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCAAGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCA
CAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCC
TTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCG
TCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAGCCTCC
CGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGGCACCC
ACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGCCGTGT
TTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGAAAC
GAACTGAACGTCTGAAACGAAGGTGGCGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAAGCGGG
GAGGAGCGACCGCTACAATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTCCCCGG
AGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGTGGCCA
ACTGGCTCCAGTCACTCCCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCTGCGCG
CCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGATCATCC
GCACGCTGAGCACTTTTAGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCGCAAGT
GCATGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGG
GTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTT
GTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTT

>94521_94521_13_TSC2-RBP1_TSC2_chr16_2108874_ENST00000568454_RBP1_chr3_139258671_ENST00000232219_length(amino acids)=573AA_BP=339
MLHMEGFSGASWSTMAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEH
AVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQ
WMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPC
WKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTS
PAPAPALAKRGGATATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKML
VNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEK

--------------------------------------------------------------
>94521_94521_14_TSC2-RBP1_TSC2_chr16_2108874_ENST00000568454_RBP1_chr3_139258674_ENST00000232219_length(transcript)=1974nt_BP=1076nt
AGTTTTAAGTCATGGCGGGTGCGAACGGGTCTCTGCTGCAGGCGGCTCCGTGACAGCTCCTGCTTCACATGGAGGGGTTTTCTGGTGCGT
CCTGGTCCACCATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAA
ATCCCAGGTCTGCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATC
GCATCCGGATGATAGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGTCGCGG
ATCTGTTGCAGCCGGAGCGGCCGCTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCGTTTGG
GGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCAAGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCA
CAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGCTGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCC
TTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTACATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCG
TCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCTACAACTGCCTGCCGGCTGAGAGCCTCC
CGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCGGAACCTCCTTGGCACCC
ACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGAGCCGTGT
TTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGAAAC
GAACTGAACGTCTGAAACGAAGGTGGCGCGGCCTGGACAAACCTGACCCTTCGACATCCCCCGCCCCTGCGCCCGCCCTCGCTAAGCGGG
GAGGAGCGACCGCTACAATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGCCCCCTGTCCCCGG
AGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGCCGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGTGGCCA
ACTGGCTCCAGTCACTCCCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAGGAGTACCTGCGCG
CCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAGCCAGACAAAGAGATCGTGCAGGACGGTGACCATATGATCATCC
GCACGCTGAGCACTTTTAGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATAGATGACCGCAAGT
GCATGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGG
GTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTT
GTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTT

>94521_94521_14_TSC2-RBP1_TSC2_chr16_2108874_ENST00000568454_RBP1_chr3_139258674_ENST00000232219_length(amino acids)=573AA_BP=339
MLHMEGFSGASWSTMAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEH
AVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQ
WMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPC
WKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQKRTERLKRRWRGLDKPDPSTS
PAPAPALAKRGGATATMDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPGSLQPSRPLVANWLQSLPEMPVDFTGYWKML
VNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEK

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Fusion Gene PPI Analysis for TSC2-RBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TSC2-RBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TSC2-RBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource