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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TSFM-HMGA2 (FusionGDB2 ID:94553)

Fusion Gene Summary for TSFM-HMGA2

Fusion gene summary

Fusion gene information	Fusion gene name: TSFM-HMGA2
	Fusion gene ID: 94553
		Hgene	Tgene
	Gene symbol	TSFM	HMGA2
	Gene ID	10102	8091
	Gene name	Ts translation elongation factor, mitochondrial	high mobility group AT-hook 2
	Synonyms	EFTS\|EFTSMT	BABL\|HMGI-C\|HMGIC\|LIPO\|STQTL9
	Cytomap	12q14.1	12q14.3
	Type of gene	protein-coding	protein-coding
	Description	elongation factor Ts, mitochondrialEF-TsEF-TsMtmitochondrial elongation factor Ts	high mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C
	Modification date	20200313	20200329
	UniProtAcc	.	P52926
	Ensembl transtripts involved in fusion gene	ENST00000497617, ENST00000323833, ENST00000350762, ENST00000454289, ENST00000540550, ENST00000543727, ENST00000548851, ENST00000550559,	ENST00000393577, ENST00000403681, ENST00000541363, ENST00000354636, ENST00000393578, ENST00000425208, ENST00000536545,
Fusion gene scores	* DoF score	26 X 8 X 7=1456	16 X 12 X 5=960
	# samples	30	15
	** MAII score	log2(30/1456*10)=-2.27897594970282 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/960*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TSFM [Title/Abstract] AND HMGA2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TSFM(58180074)-HMGA2(66345163), # samples:3
Anticipated loss of major functional domain due to fusion event.	TSFM-HMGA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TSFM-HMGA2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. TSFM-HMGA2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TSFM	GO:0070129	regulation of mitochondrial translation	27677415
Tgene	HMGA2	GO:0000122	negative regulation of transcription by RNA polymerase II	14627817
Tgene	HMGA2	GO:0002062	chondrocyte differentiation	21484705
Tgene	HMGA2	GO:0006284	base-excision repair	19465398
Tgene	HMGA2	GO:0007095	mitotic G2 DNA damage checkpoint	16061642
Tgene	HMGA2	GO:0010564	regulation of cell cycle process	14645522
Tgene	HMGA2	GO:0010628	positive regulation of gene expression	18832382
Tgene	HMGA2	GO:0031052	chromosome breakage	19549901
Tgene	HMGA2	GO:0031507	heterochromatin assembly	16901784
Tgene	HMGA2	GO:0035978	histone H2A-S139 phosphorylation	16061642
Tgene	HMGA2	GO:0035986	senescence-associated heterochromatin focus assembly	16901784
Tgene	HMGA2	GO:0035988	chondrocyte proliferation	21484705
Tgene	HMGA2	GO:0042769	DNA damage response, detection of DNA damage	19465398
Tgene	HMGA2	GO:0043065	positive regulation of apoptotic process	16061642
Tgene	HMGA2	GO:0043066	negative regulation of apoptotic process	19465398
Tgene	HMGA2	GO:0043392	negative regulation of DNA binding	14645522
Tgene	HMGA2	GO:0043922	negative regulation by host of viral transcription	17005673
Tgene	HMGA2	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	17005673
Tgene	HMGA2	GO:0045892	negative regulation of transcription, DNA-templated	18832382
Tgene	HMGA2	GO:0045893	positive regulation of transcription, DNA-templated	15225648\|15755872\|17005673\|17324944\|17426251
Tgene	HMGA2	GO:0045944	positive regulation of transcription by RNA polymerase II	14645522\|18832382
Tgene	HMGA2	GO:0071158	positive regulation of cell cycle arrest	16061642
Tgene	HMGA2	GO:0071902	positive regulation of protein serine/threonine kinase activity	19549901
Tgene	HMGA2	GO:0090402	oncogene-induced cell senescence	16901784
Tgene	HMGA2	GO:2000648	positive regulation of stem cell proliferation	21484705
Tgene	HMGA2	GO:2000679	positive regulation of transcription regulatory region DNA binding	18832382
Tgene	HMGA2	GO:2000685	positive regulation of cellular response to X-ray	16061642
Tgene	HMGA2	GO:2001022	positive regulation of response to DNA damage stimulus	16061642\|19465398
Tgene	HMGA2	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	19549901
Tgene	HMGA2	GO:2001038	regulation of cellular response to drug	16061642

Fusion gene breakpoints across TSFM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HMGA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-GN-A26D-06A	TSFM	chr12	58180074	-	HMGA2	chr12	66345163	+
ChimerDB4	SKCM	TCGA-GN-A26D-06A	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+

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Fusion Gene ORF analysis for TSFM-HMGA2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000497617	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
3UTR-3CDS	ENST00000497617	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
3UTR-3CDS	ENST00000497617	ENST00000541363	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
3UTR-intron	ENST00000497617	ENST00000354636	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
3UTR-intron	ENST00000497617	ENST00000393578	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
3UTR-intron	ENST00000497617	ENST00000425208	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
3UTR-intron	ENST00000497617	ENST00000536545	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000323833	ENST00000354636	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000323833	ENST00000393578	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000323833	ENST00000425208	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000323833	ENST00000536545	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000350762	ENST00000354636	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000350762	ENST00000393578	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000350762	ENST00000425208	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000350762	ENST00000536545	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000454289	ENST00000354636	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000454289	ENST00000393578	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000454289	ENST00000425208	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000454289	ENST00000536545	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000540550	ENST00000354636	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000540550	ENST00000393578	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000540550	ENST00000425208	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000540550	ENST00000536545	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000543727	ENST00000354636	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000543727	ENST00000393578	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000543727	ENST00000425208	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000543727	ENST00000536545	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000548851	ENST00000354636	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000548851	ENST00000393578	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000548851	ENST00000425208	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000548851	ENST00000536545	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000550559	ENST00000354636	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000550559	ENST00000393578	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000550559	ENST00000425208	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
5CDS-intron	ENST00000550559	ENST00000536545	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
Frame-shift	ENST00000323833	ENST00000541363	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
Frame-shift	ENST00000350762	ENST00000541363	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
Frame-shift	ENST00000454289	ENST00000541363	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
Frame-shift	ENST00000540550	ENST00000541363	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
Frame-shift	ENST00000543727	ENST00000541363	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
Frame-shift	ENST00000548851	ENST00000541363	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
Frame-shift	ENST00000550559	ENST00000541363	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000323833	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000323833	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000350762	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000350762	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000454289	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000454289	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000540550	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000540550	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000543727	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000543727	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000548851	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000548851	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000550559	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+
In-frame	ENST00000550559	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000543727	TSFM	chr12	58180074	+	ENST00000403681	HMGA2	chr12	66345163	+	3501	417	6	497	163
ENST00000543727	TSFM	chr12	58180074	+	ENST00000393577	HMGA2	chr12	66345163	+	631	417	6	524	172
ENST00000550559	TSFM	chr12	58180074	+	ENST00000403681	HMGA2	chr12	66345163	+	3459	375	15	455	146
ENST00000550559	TSFM	chr12	58180074	+	ENST00000393577	HMGA2	chr12	66345163	+	589	375	15	482	155
ENST00000548851	TSFM	chr12	58180074	+	ENST00000403681	HMGA2	chr12	66345163	+	3459	375	15	455	146
ENST00000548851	TSFM	chr12	58180074	+	ENST00000393577	HMGA2	chr12	66345163	+	589	375	15	482	155
ENST00000454289	TSFM	chr12	58180074	+	ENST00000403681	HMGA2	chr12	66345163	+	3657	573	42	653	203
ENST00000454289	TSFM	chr12	58180074	+	ENST00000393577	HMGA2	chr12	66345163	+	787	573	42	680	212
ENST00000540550	TSFM	chr12	58180074	+	ENST00000403681	HMGA2	chr12	66345163	+	3501	417	6	497	163
ENST00000540550	TSFM	chr12	58180074	+	ENST00000393577	HMGA2	chr12	66345163	+	631	417	6	524	172
ENST00000323833	TSFM	chr12	58180074	+	ENST00000403681	HMGA2	chr12	66345163	+	3470	386	26	466	146
ENST00000323833	TSFM	chr12	58180074	+	ENST00000393577	HMGA2	chr12	66345163	+	600	386	26	493	155
ENST00000350762	TSFM	chr12	58180074	+	ENST00000403681	HMGA2	chr12	66345163	+	3733	649	409	729	106
ENST00000350762	TSFM	chr12	58180074	+	ENST00000393577	HMGA2	chr12	66345163	+	863	649	409	756	115

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000543727	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.005733472	0.99426657
ENST00000543727	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.027045429	0.9729546
ENST00000550559	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.00585893	0.99414104
ENST00000550559	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.019325556	0.98067445
ENST00000548851	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.00585893	0.99414104
ENST00000548851	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.019325556	0.98067445
ENST00000454289	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.069384895	0.93061507
ENST00000454289	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.20960799	0.790392
ENST00000540550	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.005733472	0.99426657
ENST00000540550	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.027045429	0.9729546
ENST00000323833	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.005839227	0.9941607
ENST00000323833	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.02162355	0.9783764
ENST00000350762	ENST00000403681	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.020668495	0.9793315
ENST00000350762	ENST00000393577	TSFM	chr12	58180074	+	HMGA2	chr12	66345163	+	0.021513255	0.9784868

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Fusion Genomic Features for TSFM-HMGA2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TSFM	chr12	58180074	+	HMGA2	chr12	66345162	+	2.01E-10	1
TSFM	chr12	58180074	+	HMGA2	chr12	66345162	+	2.01E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSFM-HMGA2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:58180074/chr12:66345163)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HMGA2 P52926
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250\|UniProtKB:P52927, ECO:0000269\|PubMed:14645522, ECO:0000269\|PubMed:28796236}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000354636

24_34

107.0

DNA binding

Note=A.T hook 1

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000354636

44_54

107.0

DNA binding

Note=A.T hook 2

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000354636

71_82

107.0

DNA binding

Note=A.T hook 3

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000393578

24_34

91.0

DNA binding

Note=A.T hook 1

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000393578

44_54

91.0

DNA binding

Note=A.T hook 2

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000393578

71_82

91.0

DNA binding

Note=A.T hook 3

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000425208

24_34

93.0

DNA binding

Note=A.T hook 1

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000425208

44_54

93.0

DNA binding

Note=A.T hook 2

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000425208

71_82

93.0

DNA binding

Note=A.T hook 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000403681

24_34

110.0

DNA binding

Note=A.T hook 1

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000403681

44_54

110.0

DNA binding

Note=A.T hook 2

Tgene

HMGA2

chr12:58180074

chr12:66345163

ENST00000403681

71_82

110.0

DNA binding

Note=A.T hook 3

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Fusion Gene Sequence for TSFM-HMGA2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>94553_94553_1_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000323833_HMGA2_chr12_66345163_ENST00000393577_length(transcript)=600nt_BP=386nt
GGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGT
CTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGA
AGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGC
TCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGG
AAGGAAACACAACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACC
CGGGCAATCTTATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTG

>94553_94553_1_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000323833_HMGA2_chr12_66345163_ENST00000393577_length(amino acids)=155AA_BP=120
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG

--------------------------------------------------------------
>94553_94553_2_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000323833_HMGA2_chr12_66345163_ENST00000403681_length(transcript)=3470nt_BP=386nt
GGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGT
CTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGA
AGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGC
TCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGG
AAGGAAACACAACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGT
CTGCCGAAGAGGACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCAC
TTATTCTGTATTGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACA
TAACCTTAAAAAGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACA
CAGCTTAACAATGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGA
GAAAAACCGAATTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATTCATATAGGAAGA
ACGCGGTGTGTAACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGAC
TAGATACTACTTTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAATGCTGAT
GTATCCTTTCATTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTAT
TTATGGATATCACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAATCTACTTC
CTACAGAGCCAAAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTG
TAATTTAATGAAAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTAT
AGTTATACATCAATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTC
TTTTCATTGTGTATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCATATGTGTTACTTCAAGTAATACGTTTTGACA
TAAGATGGTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAACTGCACTTTTAGCCAGAGATGCAATATATCCC
CACTACTCAATACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAGAAAAAAA
CTTACTGGGTAGGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCAT
GACTATGTATTTTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAAT
TTTTTAACCAAGTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATTTAAATAT
TACCCTCCAAGTCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGA
ACTTGTTACTTGCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGA
CATTTGATAGAAAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAA
GCTTTGTAGGTGAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCT
TGACAAATATTTTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTT
TATGCCTTTCTCTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCA
GTATGGCTTTTAGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTC
TCTGAGACTGGCAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGTTAA
ATAAGCAAATAAACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAA
AATGGAAGCAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGT
ACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGA
ACATCATAAAATTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATA
AGACTGGACATTTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTC
TCCCTGTTCCTTTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTT
GAAAATATTTCTCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTCCTGCTCT

>94553_94553_2_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000323833_HMGA2_chr12_66345163_ENST00000403681_length(amino acids)=146AA_BP=120
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG

--------------------------------------------------------------
>94553_94553_3_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000350762_HMGA2_chr12_66345163_ENST00000393577_length(transcript)=863nt_BP=649nt
GTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTT
CTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTG
CGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGACGGAGTCTTGCTCTGTG
GCCCAGGCCGGCGTGCAATGAGTTGTGTAGTTTTTGCCTGTACGGTCATGCGTCTCTTAATAGGAAGATACATTCTGAGAAATGGCGTCG
TTAGGAGATTTTGGCTTATGCACATCATAGAGTACCTACACAAACCTAGATGGTATATTGTACTACAACCTGGGCTATATGGAATTGCCA
GCTGCTCCTAGGCTACAAACCGTTACAAAATGTTACTGGACTGAATACTGTAGGCAGTTGTAACACAGTGGCAGAGATCTGGCTCCACAA
GGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAA
CACAACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAA
TCTTATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAA

>94553_94553_3_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000350762_HMGA2_chr12_66345163_ENST00000393577_length(amino acids)=115AA_BP=6
MVYCTTTWAIWNCQLLLGYKPLQNVTGLNTVGSCNTVAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEPQQVVQKKPA

--------------------------------------------------------------
>94553_94553_4_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000350762_HMGA2_chr12_66345163_ENST00000403681_length(transcript)=3733nt_BP=649nt
GTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTT
CTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTG
CGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGACGGAGTCTTGCTCTGTG
GCCCAGGCCGGCGTGCAATGAGTTGTGTAGTTTTTGCCTGTACGGTCATGCGTCTCTTAATAGGAAGATACATTCTGAGAAATGGCGTCG
TTAGGAGATTTTGGCTTATGCACATCATAGAGTACCTACACAAACCTAGATGGTATATTGTACTACAACCTGGGCTATATGGAATTGCCA
GCTGCTCCTAGGCTACAAACCGTTACAAAATGTTACTGGACTGAATACTGTAGGCAGTTGTAACACAGTGGCAGAGATCTGGCTCCACAA
GGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAA
CACAACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGA
AGAGGACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCT
GTATTGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTT
AAAAAGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTA
ACAATGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAAC
CGAATTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGT
GTGTAACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATAC
TACTTTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCT
TTCATTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGA
TATCACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGA
GCCAAAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTA
ATGAAAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATA
CATCAATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCAT
TGTGTATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATG
GTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACT
CAATACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTG
GGTAGGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATG
TATTTTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAA
CCAAGTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTC
CAAGTCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTT
ACTTGCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGA
TAGAAAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGT
AGGTGAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAA
TATTTTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCT
TTCTCTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGC
TTTTAGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGA
CTGGCAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCA
AATAAACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAA
GCAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCA
AAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCAT
AAAATTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGG
ACATTTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGT
TCCTTTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATA
TTTCTCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTCCTGCTCTTTGTTAC

>94553_94553_4_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000350762_HMGA2_chr12_66345163_ENST00000403681_length(amino acids)=106AA_BP=6
MVYCTTTWAIWNCQLLLGYKPLQNVTGLNTVGSCNTVAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEPQQVVQKKPA

--------------------------------------------------------------
>94553_94553_5_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000454289_HMGA2_chr12_66345163_ENST00000393577_length(transcript)=787nt_BP=573nt
ATTTTACCTGGGGTGGGAGGTGGGGGGTAATTCCCGTATGAAATGTGTCGTCTCAAGAAATCAAGTAGAGGCGAGGACTGTGTTCCTCCG
GCCAGCAGGTGGCACCATACTCGTTTGGTGCGTTCCGCTGGAGAATTCTGGCCCTTCCGCCGCGCCGTAGGTTTGTTGCCTCACCAGTGC
GCCCGCCGGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCG
GCTGGGTCTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTC
CTCATGAAGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAG
ATCTGGCTCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTG
TTGCAGGAAGGAAACACAACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGTCAATGTTGCCTTGCCTGGGAAG
GACCACCCGGGCAATCTTATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACTTCCAAACACATGAAAGGATCCAAG

>94553_94553_5_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000454289_HMGA2_chr12_66345163_ENST00000393577_length(amino acids)=212AA_BP=177
MCRLKKSSRGEDCVPPASRWHHTRLVRSAGEFWPFRRAVGLLPHQCARRRVFIAAREMSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHT
FYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEPQQ

--------------------------------------------------------------
>94553_94553_6_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000454289_HMGA2_chr12_66345163_ENST00000403681_length(transcript)=3657nt_BP=573nt
ATTTTACCTGGGGTGGGAGGTGGGGGGTAATTCCCGTATGAAATGTGTCGTCTCAAGAAATCAAGTAGAGGCGAGGACTGTGTTCCTCCG
GCCAGCAGGTGGCACCATACTCGTTTGGTGCGTTCCGCTGGAGAATTCTGGCCCTTCCGCCGCGCCGTAGGTTTGTTGCCTCACCAGTGC
GCCCGCCGGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCG
GCTGGGTCTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTC
CTCATGAAGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAG
ATCTGGCTCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTG
TTGCAGGAAGGAAACACAACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGAGGAAACTGAAGAGACATCCTCA
CAAGAGTCTGCCGAAGAGGACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAG
TGACCACTTATTCTGTATTGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGA
AATCACATAACCTTAAAAAGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACA
GGGGACACAGCTTAACAATGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTTGTTGATCTGATAAGCAAGAGTGGG
CGGGTGAGAAAAACCGAATTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATTCATAT
AGGAAGAACGCGGTGTGTAACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGA
TAAGGACTAGATACTACTTTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAA
TGCTGATGTATCCTTTCATTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACT
CTTCTATTTATGGATATCACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAAT
CTACTTCCTACAGAGCCAAAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATC
CTCTTTGTAATTTAATGAAAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAATTTCTT
TTGCTATAGTTATACATCAATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCTCTCTCTCTTCCTCTCC
CTCTCTCTTTTCATTGTGTATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCATATGTGTTACTTCAAGTAATACGT
TTTGACATAAGATGGTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAACTGCACTTTTAGCCAGAGATGCAAT
ATATCCCCACTACTCAATACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAG
AAAAAAACTTACTGGGTAGGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTT
TCAGCATGACTATGTATTTTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACT
TGAAAATTTTTTAACCAAGTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATT
TAAATATTACCCTCCAAGTCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACTTCAAAA
GGAATGAACTTGTTACTTGCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGCTAACCCTAGTCAAAACTATTTTTG
TAAAAGACATTTGATAGAAAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATAAAATAAAAGCCAACCTTCAAAGAA
ACTTGAAGCTTTGTAGGTGAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGTTTTTAAGATTAGTTGAATATAAGA
AAATGCTTGACAAATATTTTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTA
GAGTTTTTATGCCTTTCTCTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCT
TTTGTCAGTATGGCTTTTAGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCAC
ATACCTCTCTGAGACTGGCAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGT
GCGTTAAATAAGCAAATAAACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATTGGCCAG
CTCATAAAATGGAAGCAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTACACTTTTATTTCCTGT
ATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAAAAAAAAGCTTGTGGCCAATGGAAC
AGTAAGAACATCATAAAATTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAG
CTACATAAGACTGGACATTTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTT
GACTTTCTCCCTGTTCCTTTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTT
GCTTGTTGAAAATATTTCTCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTC

>94553_94553_6_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000454289_HMGA2_chr12_66345163_ENST00000403681_length(amino acids)=203AA_BP=177
MCRLKKSSRGEDCVPPASRWHHTRLVRSAGEFWPFRRAVGLLPHQCARRRVFIAAREMSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHT
FYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEPQQ

--------------------------------------------------------------
>94553_94553_7_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000540550_HMGA2_chr12_66345163_ENST00000393577_length(transcript)=631nt_BP=417nt
GTAGGTTTGTTGCCTCACCAGTGCGCCCGCCGGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTG
GTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCT
GCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGT
GGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAG
ACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACAACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAG
GTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACT
TCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATATGAGCTTTAAGTGGAATAAAAACAGAGTTACCATGAAAAAA

>94553_94553_7_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000540550_HMGA2_chr12_66345163_ENST00000393577_length(amino acids)=172AA_BP=137
MLPHQCARRRVFIAAREMSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGG

--------------------------------------------------------------
>94553_94553_8_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000540550_HMGA2_chr12_66345163_ENST00000403681_length(transcript)=3501nt_BP=417nt
GTAGGTTTGTTGCCTCACCAGTGCGCCCGCCGGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTG
GTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCT
GCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGT
GGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAG
ACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACAACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAG
GAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATC
TTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGG
GGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTT
TAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTT
GTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCAC
ACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGA
ATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAAC
TTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAA
GTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAG
GACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAA
GGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTG
GGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGT
CTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCA
TATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAAC
TGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACAT
GCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTA
AAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTT
CTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACAT
CACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCA
AAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGC
TAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATA
AAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGT
TTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGA
TTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCC
AGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTT
CAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTA
AAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGG
CCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGG
TAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAA
AAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACT
GTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAA
GTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGT
CTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTC

>94553_94553_8_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000540550_HMGA2_chr12_66345163_ENST00000403681_length(amino acids)=163AA_BP=137
MLPHQCARRRVFIAAREMSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGG

--------------------------------------------------------------
>94553_94553_9_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000543727_HMGA2_chr12_66345163_ENST00000393577_length(transcript)=631nt_BP=417nt
GTAGGTTTGTTGCCTCACCAGTGCGCCCGCCGGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTG
GTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCT
GCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGT
GGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAG
ACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACAACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAG
GTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACT
TCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATATGAGCTTTAAGTGGAATAAAAACAGAGTTACCATGAAAAAA

>94553_94553_9_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000543727_HMGA2_chr12_66345163_ENST00000393577_length(amino acids)=172AA_BP=137
MLPHQCARRRVFIAAREMSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGG

--------------------------------------------------------------
>94553_94553_10_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000543727_HMGA2_chr12_66345163_ENST00000403681_length(transcript)=3501nt_BP=417nt
GTAGGTTTGTTGCCTCACCAGTGCGCCCGCCGGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTG
GTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCT
GCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGT
GGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAG
ACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACAACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAG
GAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATC
TTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGG
GGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTT
TAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTT
GTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCAC
ACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGA
ATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAAC
TTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAA
GTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAG
GACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAA
GGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTG
GGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGT
CTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCA
TATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAAC
TGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACAT
GCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTA
AAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTT
CTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACAT
CACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCA
AAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGC
TAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATA
AAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGT
TTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGA
TTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCC
AGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTT
CAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTA
AAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGG
CCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGG
TAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAA
AAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACT
GTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAA
GTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGT
CTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTC

>94553_94553_10_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000543727_HMGA2_chr12_66345163_ENST00000403681_length(amino acids)=163AA_BP=137
MLPHQCARRRVFIAAREMSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGG

--------------------------------------------------------------
>94553_94553_11_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000548851_HMGA2_chr12_66345163_ENST00000393577_length(transcript)=589nt_BP=375nt
ATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGT
CAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGG
AAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAG
GCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACA
ACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTT
ATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAA

>94553_94553_11_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000548851_HMGA2_chr12_66345163_ENST00000393577_length(amino acids)=155AA_BP=120
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG

--------------------------------------------------------------
>94553_94553_12_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000548851_HMGA2_chr12_66345163_ENST00000403681_length(transcript)=3459nt_BP=375nt
ATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGT
CAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGG
AAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAG
GCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACA
ACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAG
GACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTAT
TGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAA
AGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAA
TGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAA
TTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGT
AACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACT
TTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCA
TTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATC
ACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCA
AAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGA
AAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATC
AATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTG
TATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTG
ACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAAT
ACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTA
GGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATT
TTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAA
GTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAG
TCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTT
GCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGA
AAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGT
GAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATT
TTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCT
CTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTT
AGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGG
CAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATA
AACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAA
TTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAAC
ACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAA
TTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACAT
TTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCT
TTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTC
TCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTCCTGCTCTTTGTTACAGTT

>94553_94553_12_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000548851_HMGA2_chr12_66345163_ENST00000403681_length(amino acids)=146AA_BP=120
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG

--------------------------------------------------------------
>94553_94553_13_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000550559_HMGA2_chr12_66345163_ENST00000393577_length(transcript)=589nt_BP=375nt
ATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGT
CAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGG
AAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAG
GCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACA
ACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTT
ATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAA

>94553_94553_13_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000550559_HMGA2_chr12_66345163_ENST00000393577_length(amino acids)=155AA_BP=120
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG

--------------------------------------------------------------
>94553_94553_14_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000550559_HMGA2_chr12_66345163_ENST00000403681_length(transcript)=3459nt_BP=375nt
ATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGT
CAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGG
AAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAG
GCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACA
ACTGTATTAGTAGAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAG
GACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTAT
TGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAA
AGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAA
TGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAA
TTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGT
AACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACT
TTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCA
TTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATC
ACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCA
AAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGA
AAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATC
AATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTG
TATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTG
ACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAAT
ACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTA
GGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATT
TTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAA
GTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAG
TCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTT
GCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGA
AAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGT
GAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATT
TTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCT
CTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTT
AGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGG
CAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATA
AACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAA
TTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAAC
ACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAA
TTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACAT
TTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCT
TTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTC
TCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTCCTGCTCTTTGTTACAGTT

>94553_94553_14_TSFM-HMGA2_TSFM_chr12_58180074_ENST00000550559_HMGA2_chr12_66345163_ENST00000403681_length(amino acids)=146AA_BP=120
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG

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Fusion Gene PPI Analysis for TSFM-HMGA2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	HMGA2	chr12:58180074	chr12:66345163	ENST00000354636		0	4	44_63	0	107.0	E4F1
Tgene	HMGA2	chr12:58180074	chr12:66345163	ENST00000393578		0	4	44_63	0	91.0	E4F1
Tgene	HMGA2	chr12:58180074	chr12:66345163	ENST00000425208		0	4	44_63	0	93.0	E4F1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	HMGA2	chr12:58180074	chr12:66345163	ENST00000403681		2	5	44_63	83.0	110.0	E4F1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TSFM-HMGA2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TSFM-HMGA2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source