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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TSFM-LYZ (FusionGDB2 ID:94560)

Fusion Gene Summary for TSFM-LYZ

check button Fusion gene summary
Fusion gene informationFusion gene name: TSFM-LYZ
Fusion gene ID: 94560
HgeneTgene
Gene symbol

TSFM

LYZ

Gene ID

10102

4069

Gene nameTs translation elongation factor, mitochondriallysozyme
SynonymsEFTS|EFTSMTLYZF1|LZM
Cytomap

12q14.1

12q15

Type of geneprotein-codingprotein-coding
Descriptionelongation factor Ts, mitochondrialEF-TsEF-TsMtmitochondrial elongation factor Tslysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1
Modification date2020031320200313
UniProtAcc.

P61626

Ensembl transtripts involved in fusion geneENST00000497617, ENST00000323833, 
ENST00000350762, ENST00000454289, 
ENST00000543727, ENST00000548851, 
ENST00000550559, ENST00000540550, 
ENST00000261267, ENST00000548839, 
ENST00000549690, 
Fusion gene scores* DoF score26 X 8 X 7=145651 X 27 X 13=17901
# samples 3060
** MAII scorelog2(30/1456*10)=-2.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(60/17901*10)=-4.89893387178018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSFM [Title/Abstract] AND LYZ [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSFM(58186856)-LYZ(69743888), # samples:2
Anticipated loss of major functional domain due to fusion event.TSFM-LYZ seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTSFM

GO:0070129

regulation of mitochondrial translation

27677415

TgeneLYZ

GO:0031640

killing of cells of other organism

9727055

TgeneLYZ

GO:0042742

defense response to bacterium

21093056

TgeneLYZ

GO:0050830

defense response to Gram-positive bacterium

21093056


check buttonFusion gene breakpoints across TSFM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LYZ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0138-01ATSFMchr12

58186856

+LYZchr12

69743888

+


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Fusion Gene ORF analysis for TSFM-LYZ

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497617ENST00000261267TSFMchr12

58186856

+LYZchr12

69743888

+
3UTR-3CDSENST00000497617ENST00000548839TSFMchr12

58186856

+LYZchr12

69743888

+
3UTR-3CDSENST00000497617ENST00000549690TSFMchr12

58186856

+LYZchr12

69743888

+
Frame-shiftENST00000323833ENST00000548839TSFMchr12

58186856

+LYZchr12

69743888

+
Frame-shiftENST00000350762ENST00000548839TSFMchr12

58186856

+LYZchr12

69743888

+
Frame-shiftENST00000454289ENST00000548839TSFMchr12

58186856

+LYZchr12

69743888

+
Frame-shiftENST00000543727ENST00000548839TSFMchr12

58186856

+LYZchr12

69743888

+
Frame-shiftENST00000548851ENST00000548839TSFMchr12

58186856

+LYZchr12

69743888

+
Frame-shiftENST00000550559ENST00000548839TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000323833ENST00000261267TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000323833ENST00000549690TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000350762ENST00000261267TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000350762ENST00000549690TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000454289ENST00000261267TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000454289ENST00000549690TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000543727ENST00000261267TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000543727ENST00000549690TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000548851ENST00000261267TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000548851ENST00000549690TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000550559ENST00000261267TSFMchr12

58186856

+LYZchr12

69743888

+
In-frameENST00000550559ENST00000549690TSFMchr12

58186856

+LYZchr12

69743888

+
intron-3CDSENST00000540550ENST00000261267TSFMchr12

58186856

+LYZchr12

69743888

+
intron-3CDSENST00000540550ENST00000548839TSFMchr12

58186856

+LYZchr12

69743888

+
intron-3CDSENST00000540550ENST00000549690TSFMchr12

58186856

+LYZchr12

69743888

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000543727TSFMchr1258186856+ENST00000261267LYZchr1269743888+19546286938310
ENST00000543727TSFMchr1258186856+ENST00000549690LYZchr1269743888+11366286905299
ENST00000550559TSFMchr1258186856+ENST00000261267LYZchr1269743888+191258615896293
ENST00000550559TSFMchr1258186856+ENST00000549690LYZchr1269743888+109458615863282
ENST00000548851TSFMchr1258186856+ENST00000261267LYZchr1269743888+191258615896293
ENST00000548851TSFMchr1258186856+ENST00000549690LYZchr1269743888+109458615863282
ENST00000454289TSFMchr1258186856+ENST00000261267LYZchr1269743888+2110784421094350
ENST00000454289TSFMchr1258186856+ENST00000549690LYZchr1269743888+1292784421061339
ENST00000323833TSFMchr1258186856+ENST00000261267LYZchr1269743888+198666026970314
ENST00000323833TSFMchr1258186856+ENST00000549690LYZchr1269743888+116866026937303
ENST00000350762TSFMchr1258186856+ENST00000261267LYZchr1269743888+21868604091170253
ENST00000350762TSFMchr1258186856+ENST00000549690LYZchr1269743888+13688604091137242

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000543727ENST00000261267TSFMchr1258186856+LYZchr1269743888+0.0018881670.99811184
ENST00000543727ENST00000549690TSFMchr1258186856+LYZchr1269743888+0.0060100080.99399006
ENST00000550559ENST00000261267TSFMchr1258186856+LYZchr1269743888+0.0020043510.99799573
ENST00000550559ENST00000549690TSFMchr1258186856+LYZchr1269743888+0.0069690340.99303097
ENST00000548851ENST00000261267TSFMchr1258186856+LYZchr1269743888+0.0020043510.99799573
ENST00000548851ENST00000549690TSFMchr1258186856+LYZchr1269743888+0.0069690340.99303097
ENST00000454289ENST00000261267TSFMchr1258186856+LYZchr1269743888+0.0216808560.9783191
ENST00000454289ENST00000549690TSFMchr1258186856+LYZchr1269743888+0.066741480.9332585
ENST00000323833ENST00000261267TSFMchr1258186856+LYZchr1269743888+0.0012693310.9987307
ENST00000323833ENST00000549690TSFMchr1258186856+LYZchr1269743888+0.007558990.99244106
ENST00000350762ENST00000261267TSFMchr1258186856+LYZchr1269743888+0.0021950380.99780494
ENST00000350762ENST00000549690TSFMchr1258186856+LYZchr1269743888+0.0067279330.9932721

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Fusion Genomic Features for TSFM-LYZ


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TSFMchr1258186856+LYZchr1269743887+1.09E-091
TSFMchr1258186856+LYZchr1269743887+1.09E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TSFM-LYZ


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:58186856/chr12:69743888)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LYZ

P61626

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLYZchr12:58186856chr12:69743888ENST000002612670419_14845149.0DomainC-type lysozyme


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Fusion Gene Sequence for TSFM-LYZ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94560_94560_1_TSFM-LYZ_TSFM_chr12_58186856_ENST00000323833_LYZ_chr12_69743888_ENST00000261267_length(transcript)=1986nt_BP=660nt
GGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGT
CTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGA
AGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGC
TCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGG
AAGGAAACACAACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAATTTAAAATTTCAACTGTTGGTCCAGCAAGTAG
CCCTTGGAACCATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAAGTGCAGTGGCTCACGCCTGTAAACCTAGCAC
TTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGGTTTCTTGAATTCCTCTGAGCTTTCTGGACTTCCAGCTGGGCCTGACAGAGAAGGCT
CACTCAAGGATCAGTTGGCTTTAGCAATTGGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTG
GAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTC
ATTTATCCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAG
CATGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTT
CAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTT
TACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTC
AGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCTCCAGTACATTCCGTTCTTTTTTTTTTT
GAGACAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTC
CTGCCTCAGCCTCCCGAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCAC
CGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTG
CGCCCGGCCACATTCAGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAATGATACGATTATGCCCAATATTAAGTAAAAAATATAA
GAAAAGGTTATCTTAAATAGATCTTAGGCAAAATACCAGCTGATGAAGGCATCTGATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGT
AAAAATAACCACTTTTTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGACTGCCTGAATTGAGAATTTT
GATTTCTTAAAGTGTGTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAATTTAATTCATGTATTATGATTAAATCTGAGGCAGATGAG
CTTACAAGTATTGAAATAATTACTAATTAATCACAAATGTGAAGTTATGCATGATGTAAAAAATACAAACATTCTAATTAAAGGCTTTGC

>94560_94560_1_TSFM-LYZ_TSFM_chr12_58186856_ENST00000323833_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=314AA_BP=161
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG
WSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKVQWLTPVNLALWEAEAGGS
LEGFLNSSELSGLPAGPDREGSLKDQLALAIGMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQ

--------------------------------------------------------------
>94560_94560_2_TSFM-LYZ_TSFM_chr12_58186856_ENST00000323833_LYZ_chr12_69743888_ENST00000549690_length(transcript)=1168nt_BP=660nt
GGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGT
CTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGA
AGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGC
TCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGG
AAGGAAACACAACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAATTTAAAATTTCAACTGTTGGTCCAGCAAGTAG
CCCTTGGAACCATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAAGTGCAGTGGCTCACGCCTGTAAACCTAGCAC
TTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGGTTTCTTGAATTCCTCTGAGCTTTCTGGACTTCCAGCTGGGCCTGACAGAGAAGGCT
CACTCAAGGATCAGTTGGCTTTAGCAATTGGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTG
GAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTC
ATTTATCCTGCAGTGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAA
TTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACA
AATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTA

>94560_94560_2_TSFM-LYZ_TSFM_chr12_58186856_ENST00000323833_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=303AA_BP=161
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG
WSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKVQWLTPVNLALWEAEAGGS
LEGFLNSSELSGLPAGPDREGSLKDQLALAIGMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSGWHG

--------------------------------------------------------------
>94560_94560_3_TSFM-LYZ_TSFM_chr12_58186856_ENST00000350762_LYZ_chr12_69743888_ENST00000261267_length(transcript)=2186nt_BP=860nt
GTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTT
CTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTG
CGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGACGGAGTCTTGCTCTGTG
GCCCAGGCCGGCGTGCAATGAGTTGTGTAGTTTTTGCCTGTACGGTCATGCGTCTCTTAATAGGAAGATACATTCTGAGAAATGGCGTCG
TTAGGAGATTTTGGCTTATGCACATCATAGAGTACCTACACAAACCTAGATGGTATATTGTACTACAACCTGGGCTATATGGAATTGCCA
GCTGCTCCTAGGCTACAAACCGTTACAAAATGTTACTGGACTGAATACTGTAGGCAGTTGTAACACAGTGGCAGAGATCTGGCTCCACAA
GGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAA
CACAACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAATTTAAAATTTCAACTGTTGGTCCAGCAAGTAGCCCTTGG
AACCATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAAGGTTTCTTGAATTCCTCTGAGCTTTCTGGACTTCCAGC
TGGGCCTGACAGAGAAGGCTCACTCAAGGATCAGTTGGCTTTAGCAATTGGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACG
AGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCC
AGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCG
TGATCCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTA
ACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCC
CTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACA
TTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCTCCAGTAC
ATTCCGTTCTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCT
CCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTT
TAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGG
ATTACAGGCGTGAGCCACTGCGCCCGGCCACATTCAGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAATGATACGATTATGCCCA
ATATTAAGTAAAAAATATAAGAAAAGGTTATCTTAAATAGATCTTAGGCAAAATACCAGCTGATGAAGGCATCTGATGCCTTCATCTGTT
CAGTCATCTCCAAAAACAGTAAAAATAACCACTTTTTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGA
CTGCCTGAATTGAGAATTTTGATTTCTTAAAGTGTGTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAATTTAATTCATGTATTATGA
TTAAATCTGAGGCAGATGAGCTTACAAGTATTGAAATAATTACTAATTAATCACAAATGTGAAGTTATGCATGATGTAAAAAATACAAAC

>94560_94560_3_TSFM-LYZ_TSFM_chr12_58186856_ENST00000350762_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=253AA_BP=8
MVYCTTTWAIWNCQLLLGYKPLQNVTGLNTVGSCNTVAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSR
NLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGMCLAKWESGYNTRATNYNAGDRSTDYGIF

--------------------------------------------------------------
>94560_94560_4_TSFM-LYZ_TSFM_chr12_58186856_ENST00000350762_LYZ_chr12_69743888_ENST00000549690_length(transcript)=1368nt_BP=860nt
GTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTT
CTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTG
CGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGACGGAGTCTTGCTCTGTG
GCCCAGGCCGGCGTGCAATGAGTTGTGTAGTTTTTGCCTGTACGGTCATGCGTCTCTTAATAGGAAGATACATTCTGAGAAATGGCGTCG
TTAGGAGATTTTGGCTTATGCACATCATAGAGTACCTACACAAACCTAGATGGTATATTGTACTACAACCTGGGCTATATGGAATTGCCA
GCTGCTCCTAGGCTACAAACCGTTACAAAATGTTACTGGACTGAATACTGTAGGCAGTTGTAACACAGTGGCAGAGATCTGGCTCCACAA
GGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAA
CACAACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAATTTAAAATTTCAACTGTTGGTCCAGCAAGTAGCCCTTGG
AACCATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAAGGTTTCTTGAATTCCTCTGAGCTTTCTGGACTTCCAGC
TGGGCCTGACAGAGAAGGCTCACTCAAGGATCAGTTGGCTTTAGCAATTGGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACG
AGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCC
AGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGT
TGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTAC
CATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTG
GTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATAC

>94560_94560_4_TSFM-LYZ_TSFM_chr12_58186856_ENST00000350762_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=242AA_BP=8
MVYCTTTWAIWNCQLLLGYKPLQNVTGLNTVGSCNTVAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSR
NLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGMCLAKWESGYNTRATNYNAGDRSTDYGIF

--------------------------------------------------------------
>94560_94560_5_TSFM-LYZ_TSFM_chr12_58186856_ENST00000454289_LYZ_chr12_69743888_ENST00000261267_length(transcript)=2110nt_BP=784nt
ATTTTACCTGGGGTGGGAGGTGGGGGGTAATTCCCGTATGAAATGTGTCGTCTCAAGAAATCAAGTAGAGGCGAGGACTGTGTTCCTCCG
GCCAGCAGGTGGCACCATACTCGTTTGGTGCGTTCCGCTGGAGAATTCTGGCCCTTCCGCCGCGCCGTAGGTTTGTTGCCTCACCAGTGC
GCCCGCCGGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCG
GCTGGGTCTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTC
CTCATGAAGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAG
ATCTGGCTCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTG
TTGCAGGAAGGAAACACAACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAATTTAAAATTTCAACTGTTGGTCCAG
CAAGTAGCCCTTGGAACCATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAAGGTTTCTTGAATTCCTCTGAGCTT
TCTGGACTTCCAGCTGGGCCTGACAGAGAAGGCTCACTCAAGGATCAGTTGGCTTTAGCAATTGGGATGTGTTTGGCCAAATGGGAGAGT
GGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAAT
GATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCA
AAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAA
GGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACAC
TACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAAT
GTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAA
TACATCTCCAGTACATTCCGTTCTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCAC
TGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGCTA
ATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCGGCCT
CCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCACATTCAGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAATGA
TACGATTATGCCCAATATTAAGTAAAAAATATAAGAAAAGGTTATCTTAAATAGATCTTAGGCAAAATACCAGCTGATGAAGGCATCTGA
TGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCACTTTTTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACCAA
ATGATAGAAACAGACTGCCTGAATTGAGAATTTTGATTTCTTAAAGTGTGTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAATTTAA
TTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATTGAAATAATTACTAATTAATCACAAATGTGAAGTTATGCATGATG

>94560_94560_5_TSFM-LYZ_TSFM_chr12_58186856_ENST00000454289_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=350AA_BP=247
MCRLKKSSRGEDCVPPASRWHHTRLVRSAGEFWPFRRAVGLLPHQCARRRVFIAAREMSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHT
FYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNC
ETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGMCLAKWESGYNTRATNYNAGDR

--------------------------------------------------------------
>94560_94560_6_TSFM-LYZ_TSFM_chr12_58186856_ENST00000454289_LYZ_chr12_69743888_ENST00000549690_length(transcript)=1292nt_BP=784nt
ATTTTACCTGGGGTGGGAGGTGGGGGGTAATTCCCGTATGAAATGTGTCGTCTCAAGAAATCAAGTAGAGGCGAGGACTGTGTTCCTCCG
GCCAGCAGGTGGCACCATACTCGTTTGGTGCGTTCCGCTGGAGAATTCTGGCCCTTCCGCCGCGCCGTAGGTTTGTTGCCTCACCAGTGC
GCCCGCCGGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCG
GCTGGGTCTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTC
CTCATGAAGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAG
ATCTGGCTCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTG
TTGCAGGAAGGAAACACAACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAATTTAAAATTTCAACTGTTGGTCCAG
CAAGTAGCCCTTGGAACCATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAAGGTTTCTTGAATTCCTCTGAGCTT
TCTGGACTTCCAGCTGGGCCTGACAGAGAAGGCTCACTCAAGGATCAGTTGGCTTTAGCAATTGGGATGTGTTTGGCCAAATGGGAGAGT
GGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAAT
GATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTC
AGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTG
AAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAA
TGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCT

>94560_94560_6_TSFM-LYZ_TSFM_chr12_58186856_ENST00000454289_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=339AA_BP=247
MCRLKKSSRGEDCVPPASRWHHTRLVRSAGEFWPFRRAVGLLPHQCARRRVFIAAREMSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHT
FYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNC
ETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGMCLAKWESGYNTRATNYNAGDR

--------------------------------------------------------------
>94560_94560_7_TSFM-LYZ_TSFM_chr12_58186856_ENST00000543727_LYZ_chr12_69743888_ENST00000261267_length(transcript)=1954nt_BP=628nt
GTAGGTTTGTTGCCTCACCAGTGCGCCCGCCGGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTG
GTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCT
GCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGT
GGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAG
ACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACAACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAAT
TTAAAATTTCAACTGTTGGTCCAGCAAGTAGCCCTTGGAACCATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAA
GGTTTCTTGAATTCCTCTGAGCTTTCTGGACTTCCAGCTGGGCCTGACAGAGAAGGCTCACTCAAGGATCAGTTGGCTTTAGCAATTGGG
ATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAG
ATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATAAC
ATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGTTGTCAAAAC
AGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAG
TAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTT
CTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAAT
TTACCTAAAACCTTGGTTATCAAATACATCTCCAGTACATTCCGTTCTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGGCTGGAG
TGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACG
GGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGAC
CTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCACATTCAGTTCTTATCAAAGAAA
TAACCCAGACTTAATCTTGAATGATACGATTATGCCCAATATTAAGTAAAAAATATAAGAAAAGGTTATCTTAAATAGATCTTAGGCAAA
ATACCAGCTGATGAAGGCATCTGATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCACTTTTTGTTGGGCAATATGAA
ATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGACTGCCTGAATTGAGAATTTTGATTTCTTAAAGTGTGTTTCTTTCTAAATTGC
TGTTCCTTAATTTGATTAATTTAATTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATTGAAATAATTACTAATTAATC

>94560_94560_7_TSFM-LYZ_TSFM_chr12_58186856_ENST00000543727_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=310AA_BP=207
MLPHQCARRRVFIAAREMSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGG
DLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGF
LNSSELSGLPAGPDREGSLKDQLALAIGMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIA

--------------------------------------------------------------
>94560_94560_8_TSFM-LYZ_TSFM_chr12_58186856_ENST00000543727_LYZ_chr12_69743888_ENST00000549690_length(transcript)=1136nt_BP=628nt
GTAGGTTTGTTGCCTCACCAGTGCGCCCGCCGGAGGGTGTTTATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTG
GTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGTCAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCT
GCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGGAAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGT
GGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAGGCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAG
ACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACAACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAAT
TTAAAATTTCAACTGTTGGTCCAGCAAGTAGCCCTTGGAACCATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAA
GGTTTCTTGAATTCCTCTGAGCTTTCTGGACTTCCAGCTGGGCCTGACAGAGAAGGCTCACTCAAGGATCAGTTGGCTTTAGCAATTGGG
ATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAG
ATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCATGGAGAAATC
GTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCA
CATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATA
TGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATA

>94560_94560_8_TSFM-LYZ_TSFM_chr12_58186856_ENST00000543727_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=299AA_BP=207
MLPHQCARRRVFIAAREMSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGG
DLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGF
LNSSELSGLPAGPDREGSLKDQLALAIGMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSGWHGEIVV

--------------------------------------------------------------
>94560_94560_9_TSFM-LYZ_TSFM_chr12_58186856_ENST00000548851_LYZ_chr12_69743888_ENST00000261267_length(transcript)=1912nt_BP=586nt
ATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGT
CAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGG
AAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAG
GCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACA
ACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAATTTAAAATTTCAACTGTTGGTCCAGCAAGTAGCCCTTGGAACC
ATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAAGGTTTCTTGAATTCCTCTGAGCTTTCTGGACTTCCAGCTGGG
CCTGACAGAGAAGGCTCACTCAAGGATCAGTTGGCTTTAGCAATTGGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCT
ACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGA
GCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGAT
CCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTC
CAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTC
AAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAA
GCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCTCCAGTACATTC
CGTTCTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCG
GGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGT
AGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTA
CAGGCGTGAGCCACTGCGCCCGGCCACATTCAGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAATGATACGATTATGCCCAATAT
TAAGTAAAAAATATAAGAAAAGGTTATCTTAAATAGATCTTAGGCAAAATACCAGCTGATGAAGGCATCTGATGCCTTCATCTGTTCAGT
CATCTCCAAAAACAGTAAAAATAACCACTTTTTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGACTGC
CTGAATTGAGAATTTTGATTTCTTAAAGTGTGTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAATTTAATTCATGTATTATGATTAA
ATCTGAGGCAGATGAGCTTACAAGTATTGAAATAATTACTAATTAATCACAAATGTGAAGTTATGCATGATGTAAAAAATACAAACATTC

>94560_94560_9_TSFM-LYZ_TSFM_chr12_58186856_ENST00000548851_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=293AA_BP=190
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG
WSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREG
SLKDQLALAIGMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIR

--------------------------------------------------------------
>94560_94560_10_TSFM-LYZ_TSFM_chr12_58186856_ENST00000548851_LYZ_chr12_69743888_ENST00000549690_length(transcript)=1094nt_BP=586nt
ATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGT
CAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGG
AAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAG
GCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACA
ACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAATTTAAAATTTCAACTGTTGGTCCAGCAAGTAGCCCTTGGAACC
ATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAAGGTTTCTTGAATTCCTCTGAGCTTTCTGGACTTCCAGCTGGG
CCTGACAGAGAAGGCTCACTCAAGGATCAGTTGGCTTTAGCAATTGGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCT
ACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGA
GCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTG
GAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATT
ATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTA
TTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCT

>94560_94560_10_TSFM-LYZ_TSFM_chr12_58186856_ENST00000548851_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=282AA_BP=190
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG
WSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREG
SLKDQLALAIGMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSGWHGEIVVKTEMSVSMFKVVECNSR

--------------------------------------------------------------
>94560_94560_11_TSFM-LYZ_TSFM_chr12_58186856_ENST00000550559_LYZ_chr12_69743888_ENST00000261267_length(transcript)=1912nt_BP=586nt
ATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGT
CAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGG
AAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAG
GCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACA
ACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAATTTAAAATTTCAACTGTTGGTCCAGCAAGTAGCCCTTGGAACC
ATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAAGGTTTCTTGAATTCCTCTGAGCTTTCTGGACTTCCAGCTGGG
CCTGACAGAGAAGGCTCACTCAAGGATCAGTTGGCTTTAGCAATTGGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCT
ACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGA
GCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGAT
CCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTC
CAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTC
AAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAA
GCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCTCCAGTACATTC
CGTTCTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCG
GGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGT
AGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTA
CAGGCGTGAGCCACTGCGCCCGGCCACATTCAGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAATGATACGATTATGCCCAATAT
TAAGTAAAAAATATAAGAAAAGGTTATCTTAAATAGATCTTAGGCAAAATACCAGCTGATGAAGGCATCTGATGCCTTCATCTGTTCAGT
CATCTCCAAAAACAGTAAAAATAACCACTTTTTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGACTGC
CTGAATTGAGAATTTTGATTTCTTAAAGTGTGTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAATTTAATTCATGTATTATGATTAA
ATCTGAGGCAGATGAGCTTACAAGTATTGAAATAATTACTAATTAATCACAAATGTGAAGTTATGCATGATGTAAAAAATACAAACATTC

>94560_94560_11_TSFM-LYZ_TSFM_chr12_58186856_ENST00000550559_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=293AA_BP=190
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG
WSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREG
SLKDQLALAIGMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIR

--------------------------------------------------------------
>94560_94560_12_TSFM-LYZ_TSFM_chr12_58186856_ENST00000550559_LYZ_chr12_69743888_ENST00000549690_length(transcript)=1094nt_BP=586nt
ATCGCGGCTAGAGAGATGTCGCTGCTGCGGTCGCTGCGCGTGTTTCTGGTCGCGCGGACCGGGAGCTACCCGGCTGGGTCTCTTCTGCGT
CAGTCGCCCCAGCCAAGGCACACATTTTATGCTGGGCCCCGTCTGTCTGCCTCGGCCTCCAGCAAGGAGCTCCTCATGAAGCTGCGGCGG
AAAACAGGCTACTCCTTTGTAAATTGCAAGAAAGCTCTGGAGACTTGTGGCGGGGACCTCAAACAGGCAGAGATCTGGCTCCACAAGGAG
GCCCAGAAGGAGGGCTGGAGCAAAGCTGCCAAGCTCCAAGGGAGGAAGACCAAAGAAGGCCTGATTGGGCTGTTGCAGGAAGGAAACACA
ACTGTATTAGTAGAGGTAAACTGTGAGACAGATTTTGTTTCTAGAAATTTAAAATTTCAACTGTTGGTCCAGCAAGTAGCCCTTGGAACC
ATGATGCATTGTCAGACCCTAAAGGATCAACCCTCTGCATACAGTAAAGGTTTCTTGAATTCCTCTGAGCTTTCTGGACTTCCAGCTGGG
CCTGACAGAGAAGGCTCACTCAAGGATCAGTTGGCTTTAGCAATTGGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCT
ACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGA
GCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTG
GAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATT
ATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTA
TTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCT

>94560_94560_12_TSFM-LYZ_TSFM_chr12_58186856_ENST00000550559_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=282AA_BP=190
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEG
WSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREG
SLKDQLALAIGMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSGWHGEIVVKTEMSVSMFKVVECNSR

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Fusion Gene PPI Analysis for TSFM-LYZ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TSFM-LYZ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TSFM-LYZ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource