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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TSHZ2-PIGU (FusionGDB2 ID:94608)

Fusion Gene Summary for TSHZ2-PIGU

check button Fusion gene summary
Fusion gene informationFusion gene name: TSHZ2-PIGU
Fusion gene ID: 94608
HgeneTgene
Gene symbol

TSHZ2

PIGU

Gene ID

128553

128869

Gene nameteashirt zinc finger homeobox 2phosphatidylinositol glycan anchor biosynthesis class U
SynonymsC20orf17|OVC10-2|TSH2|ZABC2|ZNF218CDC91L1|GAB1|GPIBD21
Cytomap

20q13.2

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionteashirt homolog 2cell growth-inhibiting protein 7ovarian cancer-related protein 10-2serologically defined colon cancer antigen 33 liketeashirt family zinc finger 2zinc finger protein 218phosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-li
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000371497, ENST00000603338, 
ENST00000329613, 		ENST00000374820, 
ENST00000452740, ENST00000480175, 
Fusion gene scores* DoF score24 X 19 X 5=228019 X 15 X 11=3135
# samples 2521
** MAII scorelog2(25/2280*10)=-3.18903382439002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/3135*10)=-3.90000421002328
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSHZ2 [Title/Abstract] AND PIGU [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSHZ2(51872983)-PIGU(33245048), # samples:2
Anticipated loss of major functional domain due to fusion event.TSHZ2-PIGU seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TSHZ2-PIGU seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TSHZ2-PIGU seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TSHZ2-PIGU seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePIGU

GO:0006506

GPI anchor biosynthetic process

15034568

TgenePIGU

GO:0046425

regulation of JAK-STAT cascade

15034568


check buttonFusion gene breakpoints across TSHZ2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PIGU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1405-01ATSHZ2chr20

51872983

+PIGUchr20

33245048

-
ChimerDB4OVTCGA-13-1405-01ATSHZ2chr20

51873110

+PIGUchr20

33245048

-


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Fusion Gene ORF analysis for TSHZ2-PIGU

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000371497ENST00000374820TSHZ2chr20

51873110

+PIGUchr20

33245048

-
3UTR-3CDSENST00000371497ENST00000452740TSHZ2chr20

51873110

+PIGUchr20

33245048

-
3UTR-3CDSENST00000603338ENST00000374820TSHZ2chr20

51873110

+PIGUchr20

33245048

-
3UTR-3CDSENST00000603338ENST00000452740TSHZ2chr20

51873110

+PIGUchr20

33245048

-
3UTR-intronENST00000371497ENST00000480175TSHZ2chr20

51873110

+PIGUchr20

33245048

-
3UTR-intronENST00000603338ENST00000480175TSHZ2chr20

51873110

+PIGUchr20

33245048

-
5CDS-intronENST00000329613ENST00000480175TSHZ2chr20

51872983

+PIGUchr20

33245048

-
5CDS-intronENST00000329613ENST00000480175TSHZ2chr20

51873110

+PIGUchr20

33245048

-
5CDS-intronENST00000371497ENST00000480175TSHZ2chr20

51872983

+PIGUchr20

33245048

-
5CDS-intronENST00000603338ENST00000480175TSHZ2chr20

51872983

+PIGUchr20

33245048

-
Frame-shiftENST00000329613ENST00000374820TSHZ2chr20

51872983

+PIGUchr20

33245048

-
Frame-shiftENST00000329613ENST00000374820TSHZ2chr20

51873110

+PIGUchr20

33245048

-
Frame-shiftENST00000371497ENST00000374820TSHZ2chr20

51872983

+PIGUchr20

33245048

-
Frame-shiftENST00000371497ENST00000452740TSHZ2chr20

51872983

+PIGUchr20

33245048

-
Frame-shiftENST00000603338ENST00000374820TSHZ2chr20

51872983

+PIGUchr20

33245048

-
Frame-shiftENST00000603338ENST00000452740TSHZ2chr20

51872983

+PIGUchr20

33245048

-
In-frameENST00000329613ENST00000452740TSHZ2chr20

51872983

+PIGUchr20

33245048

-
In-frameENST00000329613ENST00000452740TSHZ2chr20

51873110

+PIGUchr20

33245048

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000329613TSHZ2chr2051872983+ENST00000452740PIGUchr2033245048-18495105031651382
ENST00000329613TSHZ2chr2051873110+ENST00000452740PIGUchr2033245048-4795345629734461049

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000329613ENST00000452740TSHZ2chr2051872983+PIGUchr2033245048-0.0048731650.99512684
ENST00000329613ENST00000452740TSHZ2chr2051873110+PIGUchr2033245048-0.0012866650.9987134

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Fusion Genomic Features for TSHZ2-PIGU


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSHZ2-PIGU


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:51872983/chr20:33245048)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000329613+2213_3810351032.0Coiled coilOntology_term=ECO:0000255
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000371497+2313_3810373455.0Coiled coilOntology_term=ECO:0000255
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000603338+2313_3810341012.6666666666666Coiled coilOntology_term=ECO:0000255
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000329613+22841_91110351032.0DNA bindingNote=Homeobox%3B atypical
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000371497+23841_91110373455.0DNA bindingNote=Homeobox%3B atypical
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000603338+23841_91110341012.6666666666666DNA bindingNote=Homeobox%3B atypical
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000329613+22215_23910351032.0Zinc fingerC2H2-type 1
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000329613+22275_29910351032.0Zinc fingerC2H2-type 2
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000329613+22380_40410351032.0Zinc fingerC2H2-type 3%3B atypical
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000329613+22926_94810351032.0Zinc fingerC2H2-type 4
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000329613+22994_101710351032.0Zinc fingerC2H2-type 5
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000371497+23215_23910373455.0Zinc fingerC2H2-type 1
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000371497+23275_29910373455.0Zinc fingerC2H2-type 2
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000371497+23380_40410373455.0Zinc fingerC2H2-type 3%3B atypical
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000371497+23926_94810373455.0Zinc fingerC2H2-type 4
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000371497+23994_101710373455.0Zinc fingerC2H2-type 5
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000603338+23215_23910341012.6666666666666Zinc fingerC2H2-type 1
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000603338+23275_29910341012.6666666666666Zinc fingerC2H2-type 2
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000603338+23380_40410341012.6666666666666Zinc fingerC2H2-type 3%3B atypical
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000603338+23926_94810341012.6666666666666Zinc fingerC2H2-type 4
HgeneTSHZ2chr20:51873110chr20:33245048ENST00000603338+23994_101710341012.6666666666666Zinc fingerC2H2-type 5
TgenePIGUchr20:51872983chr20:33245048ENST00000374820011269_28943416.0RegionNote=May be involved in recognition of long-chain fatty acids in GPI
TgenePIGUchr20:51873110chr20:33245048ENST00000374820011269_28943416.0RegionNote=May be involved in recognition of long-chain fatty acids in GPI
TgenePIGUchr20:51872983chr20:33245048ENST00000374820011166_18643416.0TransmembraneHelical
TgenePIGUchr20:51872983chr20:33245048ENST00000374820011188_20843416.0TransmembraneHelical
TgenePIGUchr20:51872983chr20:33245048ENST00000374820011237_25743416.0TransmembraneHelical
TgenePIGUchr20:51872983chr20:33245048ENST00000374820011259_27943416.0TransmembraneHelical
TgenePIGUchr20:51872983chr20:33245048ENST00000374820011286_30643416.0TransmembraneHelical
TgenePIGUchr20:51872983chr20:33245048ENST00000374820011313_33343416.0TransmembraneHelical
TgenePIGUchr20:51872983chr20:33245048ENST00000374820011355_37543416.0TransmembraneHelical
TgenePIGUchr20:51872983chr20:33245048ENST00000374820011386_40643416.0TransmembraneHelical
TgenePIGUchr20:51872983chr20:33245048ENST0000037482001166_8643416.0TransmembraneHelical
TgenePIGUchr20:51873110chr20:33245048ENST00000374820011166_18643416.0TransmembraneHelical
TgenePIGUchr20:51873110chr20:33245048ENST00000374820011188_20843416.0TransmembraneHelical
TgenePIGUchr20:51873110chr20:33245048ENST00000374820011237_25743416.0TransmembraneHelical
TgenePIGUchr20:51873110chr20:33245048ENST00000374820011259_27943416.0TransmembraneHelical
TgenePIGUchr20:51873110chr20:33245048ENST00000374820011286_30643416.0TransmembraneHelical
TgenePIGUchr20:51873110chr20:33245048ENST00000374820011313_33343416.0TransmembraneHelical
TgenePIGUchr20:51873110chr20:33245048ENST00000374820011355_37543416.0TransmembraneHelical
TgenePIGUchr20:51873110chr20:33245048ENST00000374820011386_40643416.0TransmembraneHelical
TgenePIGUchr20:51873110chr20:33245048ENST0000037482001166_8643416.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000329613+1213_3801032.0Coiled coilOntology_term=ECO:0000255
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000371497+1313_3803455.0Coiled coilOntology_term=ECO:0000255
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000603338+1313_3801012.6666666666666Coiled coilOntology_term=ECO:0000255
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000329613+12841_91101032.0DNA bindingNote=Homeobox%3B atypical
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000371497+13841_91103455.0DNA bindingNote=Homeobox%3B atypical
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000603338+13841_91101012.6666666666666DNA bindingNote=Homeobox%3B atypical
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000329613+12215_23901032.0Zinc fingerC2H2-type 1
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000329613+12275_29901032.0Zinc fingerC2H2-type 2
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000329613+12380_40401032.0Zinc fingerC2H2-type 3%3B atypical
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000329613+12926_94801032.0Zinc fingerC2H2-type 4
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000329613+12994_101701032.0Zinc fingerC2H2-type 5
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000371497+13215_23903455.0Zinc fingerC2H2-type 1
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000371497+13275_29903455.0Zinc fingerC2H2-type 2
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000371497+13380_40403455.0Zinc fingerC2H2-type 3%3B atypical
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000371497+13926_94803455.0Zinc fingerC2H2-type 4
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000371497+13994_101703455.0Zinc fingerC2H2-type 5
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000603338+13215_23901012.6666666666666Zinc fingerC2H2-type 1
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000603338+13275_29901012.6666666666666Zinc fingerC2H2-type 2
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000603338+13380_40401012.6666666666666Zinc fingerC2H2-type 3%3B atypical
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000603338+13926_94801012.6666666666666Zinc fingerC2H2-type 4
HgeneTSHZ2chr20:51872983chr20:33245048ENST00000603338+13994_101701012.6666666666666Zinc fingerC2H2-type 5


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Fusion Gene Sequence for TSHZ2-PIGU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94608_94608_1_TSHZ2-PIGU_TSHZ2_chr20_51872983_ENST00000329613_PIGU_chr20_33245048_ENST00000452740_length(transcript)=1849nt_BP=510nt
AGAACACACCCGACATGTAGGCTCTATTGCAATACATCTGAAAACACAAAATCTGTTTGCTCCAAAATTGGTGATAGCCTCTGACTTAAG
ATGATGGTGGCCAGGCGAGGTGGTTCAAGCCTGTGATTCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCAGATCATGAGGTCAGGAGTT
CAAGACCAGCCTGGCCAACATGGTGAAACCTCAGGAGGCTGAGGCAGGAGAATTCCTTGAACTGGGACCCAGGAGGCAGAGGTTGCAGTG
AGCTGAGATCACGCCACTGCACTCCAGCTGGGGATACAGAGCAAGACTCCATCTCAAAAAAAGAAAAAAAAGAAAGAAAAGATGATGGCT
GCTGCGTTGCTCCATTATACAGGTAAGTTGTGCTGTCGGACATTTGTGAGCAAACATGCGGTAAAACTCCACCTAAGCAAAACGCACAGC
AAGTCACCCGAACACCATTCACAGTTTGTAACAGACGTGGATGAAGAATAGCTCTGCAGGTGGTTGAAGGCCTTTCACTGTTGGACTTGG
GAGTATCTCCGTATTCTGGAGCAGTATTTCATGAAACTCCATTAATAATATACCTCTTTCATTTCCTAATTGACTATGCTGAATTGGTGT
TTATGATAACTGATGCACTCACTGCTATTGCCCTGTATTTTGCAATCCAGGACTTCAATAAAGTTGTGTTTAAAAAGCAGAAACTCCTCC
TAGAACTGGACCAGTATGCCCCAGATGTGGCCGAACTCATCCGGACCCCTATGGAAATGCGTTACATCCCTTTGAAAGTGGCCCTGTTCT
ATCTCTTAAATCCTTACACGATTTTGTCTTGTGTTGCCAAGTCTACCTGTGCCATCAACAACACCCTCATTGCTTTCTTCATTTTGACTA
CGATAAAAGGCAGTGCTTTCCTCAGTGCTATTTTTCTTGCCTTAGCGACATACCAGTCTCTGTACCCACTCACCTTGTTTGTCCCAGGAC
TCCTCTATCTCCTCCAGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATG
TGGGAAGCCTAGTGGTAATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTG
TTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTC
AGATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCG
CCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATTCCTGAGAA
ACATCTTTGTCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACT
CTAATTTCTTTTATGCCATCACACTGACCTTCAACGTTGGGCAGATGGGCTTCTGTGGTGATAGAATGGCAGGTACTTGTCCTGAGGCCA
TCAGAGCTGCTGGTGACAGGACACCTTCCTGAACTCCTCCAGGCGCCTCTGATCTCTCCTTAGCTGCTGTTGTGTTACCTTCAGATCCTG
CTCATCTCTGATTACTTCTATGCCTTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCC

>94608_94608_1_TSHZ2-PIGU_TSHZ2_chr20_51872983_ENST00000329613_PIGU_chr20_33245048_ENST00000452740_length(amino acids)=382AA_BP=2
MQVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFLIDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPM
EMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKA
FWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEH
PIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAGSANSNFFYAITLTFNVGQMGF

--------------------------------------------------------------
>94608_94608_2_TSHZ2-PIGU_TSHZ2_chr20_51873110_ENST00000329613_PIGU_chr20_33245048_ENST00000452740_length(transcript)=4795nt_BP=3456nt
AGAACACACCCGACATGTAGGCTCTATTGCAATACATCTGAAAACACAAAATCTGTTTGCTCCAAAATTGGTGATAGCCTCTGACTTAAG
ATGATGGTGGCCAGGCGAGGTGGTTCAAGCCTGTGATTCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCAGATCATGAGGTCAGGAGTT
CAAGACCAGCCTGGCCAACATGGTGAAACCTCAGGAGGCTGAGGCAGGAGAATTCCTTGAACTGGGACCCAGGAGGCAGAGGTTGCAGTG
AGCTGAGATCACGCCACTGCACTCCAGCTGGGGATACAGAGCAAGACTCCATCTCAAAAAAAGAAAAAAAAGAAAGAAAAGATGATGGCT
GCTGCGTTGCTCCATTATACAGGCTACGCCCAGGAGGAACAGCTGAAAGAAGAGGAGGAAATAAAAGAAGAGGAGGAGGAGGAGGACAGC
GGTTCAGTAGCTCAACTGCAGGGTGGCAATGACACAGGGACGGACGAGGAGCTAGAAACGGGCCCAGAGCAAAAAGGCTGCTTCAGCTAC
CAGAACTCTCCAGGAAGTCATTTGTCCAATCAGGATGCCGAGAACGAGTCTCTGCTGAGTGACGCCAGTGATCAGGTGTCGGACATCAAG
AGTGTCTGCGGCAGAGATGCCTCAGACAAGAAAGCACACACTCACGTCAGGCTTCCAAACGAAGCACACAATTGCATGGATAAAATGACC
GCTGTCTACGCCAACATCCTGTCGGATTCCTACTGGTCAGGCCTGGGCCTTGGCTTCAAGCTGTCCAATAGTGAGAGGAGGAACTGTGAC
ACCCGAAACGGCAGCAACAAGAGTGATTTTGATTGGCACCAAGACGCTCTGTCCAAAAGCCTGCAGCAGAACTTGCCTTCTCGGTCCGTC
TCGAAACCCAGCCTGTTCAGCTCGGTGCAGTTGTACCGACAGAGCAGCAAGATGTGCGGGACTGTGTTCACAGGGGCCAGCAGATTCCGA
TGCCGACAGTGCAGCGCGGCCTATGACACCCTAGTCGAGCTGACTGTGCACATGAATGAAACGGGCCACTATCAAGATGACAACCGCAAA
AAGGACAAGCTCAGACCCACGAGCTATTCAAAGCCCAGGAAAAGGGCTTTCCAGGATATGGACAAAGAGGATGCTCAAAAGGTTCTGAAA
TGTATGTTTTGTGGCGACTCCTTTGATTCCCTCCAAGATTTGAGCGTCCACATGATTAAAACAAAACATTACCAAAAAGTGCCTTTGAAG
GAGCCAGTCCCAACCATTTCCTCGAAAATGGTCACCCCGGCTAAGAAACGCGTTTTTGATGTCAATCGGCCGTGTTCCCCCGATTCAACC
ACAGGATCTTTTGCAGATTCTTTTTCTTCTCAGAAGAACGCCAACTTGCAGTTGTCCTCCAACAACCGCTATGGCTACCAAAATGGAGCC
AGCTACACCTGGCAGTTTGAGGCCTGCAAGTCCCAGATCTTAAAGTGCATGGAGTGTGGGAGCTCCCATGACACCTTGCAGCAGCTCACC
ACCCACATGATGGTCACAGGTCACTTTCTCAAGGTCACCAGCTCTGCCTCCAAGAAAGGGAAGCAGCTGGTATTAGACCCGTTAGCAGTG
GAGAAAATGCAGTCGTTGTCTGAGGCCCCAAACAGTGATTCTCTGGCTCCCAAGCCATCCAGTAACTCAGCATCAGATTGTACAGCCTCT
ACAACTGAGTTAAAGAAAGAGAGTAAAAAAGAAAGGCCAGAGGAAACCAGCAAGGATGAGAAAGTCGTGAAAAGCGAGGACTATGAAGAT
CCTCTACAAAAACCTTTAGACCCTACAATCAAATATCAATACCTAAGGGAGGAAGACTTGGAAGATGGCTCAAAGGGTGGAGGGGACATT
TTGAAATCTTTGGAAAATACTGTCACCACAGCCATCAACAAAGCCCAAAACGGGGCCCCCAGCTGGAGTGCCTACCCCAGCATCCACGCA
GCCTACCAGCTGTCTGAGGGCACCAAGCCGCCTTTGCCTATGGGATCCCAGGTACTGCAGATCCGGCCTAATCTCACCAACAAGCTGAGG
CCCATTGCACCAAAGTGGAAAGTGATGCCACTGGTTTCTATGCCCACACACCTGGCCCCTTACACTCAAGTCAAGAAAGAGTCAGAAGAC
AAAGATGAAGCGGTGAAGGAGTGTGGGAAAGAAAGTCCCCACGAAGAGGCCTCATCTTTCAGCCACAGTGAGGGCGATTCTTTCCGCAAA
AGTGAAACACCTCCAGAAGCCAAAAAGACCGAGCTGGGTCCCCTGAAGGAGGAGGAGAAGCTGATGAAAGAGGGCAGCGAGAAGGAGAAA
CCCCAGCCCCTGGAGCCCACATCTGCTCTGAGCAATGGGTGCGCCCTCGCCAACCACGCCCCGGCCCTGCCATGCATCAACCCACTCAGC
GCCCTGCAGTCCGTCCTGAACAATCACTTGGGCAAAGCCACGGAGCCCTTGCGCTCACCTTCCTGCTCCAGCCCAAGTTCAAGCACAATT
TCCATGTTCCACAAGTCGAATCTCAATGTCATGGACAAGCCGGTCTTGAGTCCTGCCTCCACAAGGTCAGCCAGCGTGTCCAGGCGCTAC
CTGTTTGAGAACAGCGATCAGCCCATTGACCTGACCAAGTCCAAAAGCAAGAAAGCCGAGTCCTCGCAAGCACAATCTTGTATGTCCCCA
CCTCAGAAGCACGCTCTGTCTGACATCGCCGACATGGTCAAAGTCCTCCCCAAAGCCACCACCCCAAAGCCAGCCTCCTCCTCCAGGGTC
CCCCCCATGAAGCTGGAAATGGATGTCAGGCGCTTTGAGGATGTCTCCAGTGAAGTCTCAACTTTGCATAAAAGAAAAGGCCGGCAGTCC
AACTGGAATCCTCAGCATCTTCTGATTCTACAAGCCCAGTTTGCCTCGAGCCTCTTCCAGACATCAGAGGGCAAATACCTGCTGTCTGAT
CTGGGCCCACAAGAGCGTATGCAAATCTCTAAGTTTACGGGACTCTCAATGACCACTATCAGTCACTGGCTGGCCAACGTCAAGTACCAG
CTTAGGAAAACGGGCGGGACAAAATTTCTGAAAAACATGGACAAAGGCCACCCCATCTTTTATTGCAGTGACTGTGCCTCCCAGTTCAGA
ACCCCTTCTACCTACATCAGTCACTTAGAATCTCACCTGGGTTTCCAAATGAAGGACATGACCCGCTTGTCAGTGGACCAGCAAAGCAAG
GTGGAGCAAGAGATCTCCCGGGTATCGTCGGCTCAGAGGTCTCCAGAAACAATAGCTGCCGAAGAGGACACAGACTCTAAATTCAAGTGT
AAGTTGTGCTGTCGGACATTTGTGAGCAAACATGCGGTAAAACTCCACCTAAGCAAAACGCACAGCAAGTCACCCGAACACCATTCACAG
TTTGTAACAGACGTGGATGAAGAATAGCTCTGCAGGTGGTTGAAGGCCTTTCACTGTTGGACTTGGGAGTATCTCCGTATTCTGGAGCAG
TATTTCATGAAACTCCATTAATAATATACCTCTTTCATTTCCTAATTGACTATGCTGAATTGGTGTTTATGATAACTGATGCACTCACTG
CTATTGCCCTGTATTTTGCAATCCAGGACTTCAATAAAGTTGTGTTTAAAAAGCAGAAACTCCTCCTAGAACTGGACCAGTATGCCCCAG
ATGTGGCCGAACTCATCCGGACCCCTATGGAAATGCGTTACATCCCTTTGAAAGTGGCCCTGTTCTATCTCTTAAATCCTTACACGATTT
TGTCTTGTGTTGCCAAGTCTACCTGTGCCATCAACAACACCCTCATTGCTTTCTTCATTTTGACTACGATAAAAGGCAGTGCTTTCCTCA
GTGCTATTTTTCTTGCCTTAGCGACATACCAGTCTCTGTACCCACTCACCTTGTTTGTCCCAGGACTCCTCTATCTCCTCCAGCGGCAGT
ACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCCTAGTGGTAATCATTT
GCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTGTTCCAGATCTCACTCCAAACATTG
GTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTCAGATCAACGTCTTCTTCTACACCA
TCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTAAGTCCTACCCGACAG
TGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATTCCTGAGAAACATCTTTGTCCTCACCTGCATCA
TCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCTTTTATGCCATCACAC
TGACCTTCAACGTTGGGCAGATGGGCTTCTGTGGTGATAGAATGGCAGGTACTTGTCCTGAGGCCATCAGAGCTGCTGGTGACAGGACAC
CTTCCTGAACTCCTCCAGGCGCCTCTGATCTCTCCTTAGCTGCTGTTGTGTTACCTTCAGATCCTGCTCATCTCTGATTACTTCTATGCC
TTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTGCTCAAGTAGGCCTGG

>94608_94608_2_TSHZ2-PIGU_TSHZ2_chr20_51873110_ENST00000329613_PIGU_chr20_33245048_ENST00000452740_length(amino acids)=1049AA_BP=
MGIQSKTPSQKKKKKKEKMMAAALLHYTGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPGSHLS
NQDAENESLLSDASDQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSD
FDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLRPTSY
SKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFADSFS
SQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQSLSEA
PNSDSLAPKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLENTVT
TAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECG
KESPHEEASSFSHSEGDSFRKSETPPEAKKTELGPLKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSVLNNH
LGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHALSDI
ADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQERMQI
SKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEISRVS

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Fusion Gene PPI Analysis for TSHZ2-PIGU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TSHZ2-PIGU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TSHZ2-PIGU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource