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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TSNARE1-AK2 (FusionGDB2 ID:94644)

Fusion Gene Summary for TSNARE1-AK2

check button Fusion gene summary
Fusion gene informationFusion gene name: TSNARE1-AK2
Fusion gene ID: 94644
HgeneTgene
Gene symbol

TSNARE1

AK2

Gene ID

203062

204

Gene namet-SNARE domain containing 1adenylate kinase 2
Synonyms-ADK2
Cytomap

8q24.3

1p35.1

Type of geneprotein-codingprotein-coding
Descriptiont-SNARE domain-containing protein 1adenylate kinase 2, mitochondrialATP-AMP transphosphorylase 2ATP:AMP phosphotransferaseadenylate kinase isoenzyme 2, mitochondrialadenylate monophosphate kinasetestis secretory sperm-binding protein Li 220n
Modification date2020031320200313
UniProtAcc.

P54819

Ensembl transtripts involved in fusion geneENST00000307180, ENST00000519651, 
ENST00000520166, ENST00000524325, 
ENST00000518928, 		ENST00000467905, 
ENST00000491241, ENST00000354858, 
ENST00000480134, ENST00000487289, 
ENST00000373449, ENST00000548033, 
Fusion gene scores* DoF score11 X 9 X 6=5948 X 9 X 3=216
# samples 119
** MAII scorelog2(11/594*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSNARE1 [Title/Abstract] AND AK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSNARE1(143356141)-AK2(33476434), # samples:1
Anticipated loss of major functional domain due to fusion event.TSNARE1-AK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TSNARE1-AK2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TSNARE1-AK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TSNARE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0913TSNARE1chr8

143356141

-AK2chr1

33476434

-


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Fusion Gene ORF analysis for TSNARE1-AK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000307180ENST00000467905TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-3UTRENST00000519651ENST00000467905TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-3UTRENST00000520166ENST00000467905TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-3UTRENST00000524325ENST00000467905TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-5UTRENST00000307180ENST00000491241TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-5UTRENST00000519651ENST00000491241TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-5UTRENST00000520166ENST00000491241TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-5UTRENST00000524325ENST00000491241TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000307180ENST00000354858TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000307180ENST00000480134TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000307180ENST00000487289TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000519651ENST00000354858TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000519651ENST00000480134TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000519651ENST00000487289TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000520166ENST00000354858TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000520166ENST00000480134TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000520166ENST00000487289TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000524325ENST00000354858TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000524325ENST00000480134TSNARE1chr8

143356141

-AK2chr1

33476434

-
5CDS-intronENST00000524325ENST00000487289TSNARE1chr8

143356141

-AK2chr1

33476434

-
Frame-shiftENST00000307180ENST00000373449TSNARE1chr8

143356141

-AK2chr1

33476434

-
Frame-shiftENST00000307180ENST00000548033TSNARE1chr8

143356141

-AK2chr1

33476434

-
Frame-shiftENST00000519651ENST00000373449TSNARE1chr8

143356141

-AK2chr1

33476434

-
Frame-shiftENST00000519651ENST00000548033TSNARE1chr8

143356141

-AK2chr1

33476434

-
Frame-shiftENST00000524325ENST00000373449TSNARE1chr8

143356141

-AK2chr1

33476434

-
Frame-shiftENST00000524325ENST00000548033TSNARE1chr8

143356141

-AK2chr1

33476434

-
In-frameENST00000520166ENST00000373449TSNARE1chr8

143356141

-AK2chr1

33476434

-
In-frameENST00000520166ENST00000548033TSNARE1chr8

143356141

-AK2chr1

33476434

-
intron-3CDSENST00000518928ENST00000373449TSNARE1chr8

143356141

-AK2chr1

33476434

-
intron-3CDSENST00000518928ENST00000548033TSNARE1chr8

143356141

-AK2chr1

33476434

-
intron-3UTRENST00000518928ENST00000467905TSNARE1chr8

143356141

-AK2chr1

33476434

-
intron-5UTRENST00000518928ENST00000491241TSNARE1chr8

143356141

-AK2chr1

33476434

-
intron-intronENST00000518928ENST00000354858TSNARE1chr8

143356141

-AK2chr1

33476434

-
intron-intronENST00000518928ENST00000480134TSNARE1chr8

143356141

-AK2chr1

33476434

-
intron-intronENST00000518928ENST00000487289TSNARE1chr8

143356141

-AK2chr1

33476434

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000520166TSNARE1chr8143356141-ENST00000373449AK2chr133476434-43351485391553504
ENST00000520166TSNARE1chr8143356141-ENST00000548033AK2chr133476434-18411485391553504

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000520166ENST00000373449TSNARE1chr8143356141-AK2chr133476434-0.0312288010.96877116
ENST00000520166ENST00000548033TSNARE1chr8143356141-AK2chr133476434-0.0908037650.9091962

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Fusion Genomic Features for TSNARE1-AK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSNARE1-AK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:143356141/chr1:33476434)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AK2

P54819

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:19043416}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSNARE1chr8:143356141chr1:33476434ENST00000307180-1214416_478482558.6666666666666Domaint-SNARE coiled-coil homology
TgeneAK2chr8:143356141chr1:33476434ENST0000035485806100_1030240.0Nucleotide bindingAMP
TgeneAK2chr8:143356141chr1:33476434ENST0000035485806151_1520240.0Nucleotide bindingATP
TgeneAK2chr8:143356141chr1:33476434ENST000003548580625_300240.0Nucleotide bindingATP
TgeneAK2chr8:143356141chr1:33476434ENST000003548580672_740240.0Nucleotide bindingAMP
TgeneAK2chr8:143356141chr1:33476434ENST0000035485806141_1780240.0RegionLID
TgeneAK2chr8:143356141chr1:33476434ENST000003548580645_740240.0RegionNMP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSNARE1chr8:143356141chr1:33476434ENST00000307180-1214503_507482558.6666666666666Compositional biasNote=Poly-Ile
HgeneTSNARE1chr8:143356141chr1:33476434ENST00000307180-1214491_511482558.6666666666666TransmembraneHelical
TgeneAK2chr8:143356141chr1:33476434ENST0000037344957100_103231233.0Nucleotide bindingAMP
TgeneAK2chr8:143356141chr1:33476434ENST0000037344957151_152231233.0Nucleotide bindingATP
TgeneAK2chr8:143356141chr1:33476434ENST000003734495725_30231233.0Nucleotide bindingATP
TgeneAK2chr8:143356141chr1:33476434ENST000003734495772_74231233.0Nucleotide bindingAMP
TgeneAK2chr8:143356141chr1:33476434ENST0000037344957141_178231233.0RegionLID
TgeneAK2chr8:143356141chr1:33476434ENST000003734495745_74231233.0RegionNMP


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Fusion Gene Sequence for TSNARE1-AK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94644_94644_1_TSNARE1-AK2_TSNARE1_chr8_143356141_ENST00000520166_AK2_chr1_33476434_ENST00000373449_length(transcript)=4335nt_BP=1485nt
CTCAGTGTGGAGGCTGCTGGCCCTGCCATCTGTAAGAAGATGTCATACGGATCCATCGCCCGTGGAGGTGGCCTGGGGAGCCGTGGCCCT
TTCGGGGGACCTTCGAGACAAGGCTGTCAGCCCCTAGAGTGCGCTAGATGTTGGACCGAGTATGGAATCCGCCATTTCCCCTGCCCGTCG
CCAGAGAGCAAGCTGCAGAACCGCTGTGTGGGGAAGGACGGGGAAGGTGATCTGGGGCCAGCAGGCACGCCTATTGTCCCAAGGGCCAGG
AAGCGAGGGCCTGGGGTTGCCCCTGAAGGCAGCCGGATGCCGGAGCCCACCTCATCACCCACCATTGGCCCGAGGAAGGACTCGGCTGCT
GGGCCCCATGGCCGGATGGCGGGGCCCAGCACTACCCGGGCCAAGAAGAGGAAGCCCAACTTCTGCCCGCAGGAGACCGAGGTGCTGGTG
TCCAAGGTGAGCAAGCACCACCAGCTGCTGTTTGGCACGGGGCTGCTGAAGGCCGAGCCCACTCGCAGGTACCGCGTGTGGAGCCGCATC
CTGCAGGCCGTGAATGCGCTGGGCTACTGTCGCCGCGACGTTGTGGACCTGAAGCACAAGTGGCGGGACCTACGAGCCGTCGTGCGGCGC
AAGCTGGGCGACCTCCGGAAGGCGGCCCATGGCCCCAGCCCTGGTTCCGGCAAGCCCCAGGCCCTGGCTCTCACGCCCGTGGAGCAGGTG
GTGGCCAAGACCTTCTCTTGCCAGGCCCTGCCCTCCGAGGGCTTCAGTCTGGAGCCGCCCAGAGCCACCCAGGTCGATCCGTGCAACCTC
CAGGAGCTGTTCCAGGAGATGTCGGCCAACGTCTTCCGAATCAACTCCAGTGTGACCTCCTTGGAGCGGAGCCTTCAGTCCTTAGGGACA
CCGAGTGACACGCAGGAGCTTCGGGACAGCCTGCACACGGCACAGCAGGAGACCAACAAGACCATTGCAGCCAGCGCCAGCTCCGTGAAG
CAGATGGCCGAGCTGCTGCGCAGCTCCTGCCCGGAGCGTCTGCAGCAGGAGCGTCCTCAGCTGGACCGGCTGAAAACCCAGCTCTCAGAT
GCCATTCAGTGCTATGGAGTGGTGCAGAAGAAAATTGCAGAAAAGTCCAGAGCGCTGCTTCCCATGGCGCAGAGGGGCAGTAAACAGCAG
AGTCCCCAGGCCCCGTTTGCCGAGCTGGCTGATGATGAGAAGGTCTTTAACGGGAGTGACAACATGTGGCAGGGCCAGGAGCAGGCGCTG
CTCCCGGACATCACTGAAGAGGACCTGGAGGCCATCCGGCTGCGGGAGGAGGCCATCCTGCAGATGGAGAGCAACTTGCTGGATGTGAAT
CAGATCATCAAGGACTTGGCCTCCATGGTGTCAGAGCAAGGAGAAGCTGTTGATAGTATTGAAGCCAGCCTTGAGGCTGCGTCCTCGCAT
GCGGAGGCAGCCCGCCAGCTCCTGGCTGGAGCCAGCCGGCACCAACCTAGTATCAGAAGGCCAGGCGAGACTGCAACACTGCTCATCACC
CCGCGGCGTGATCCCTGCTCTTAGGTGCTGGGCAGAGGGGAAGGGTGGTCAGGGTGAGGATGGTGAGGGAGGGCTGGTGAGGGGCTCAGA
GGAATACTTGGAACAACAGCAGTGTTATTGTAGTGTGGCAGTTTCTTTTATACATAGGTGAGAGTTTTTAAAGTGTAAGGGAAAAATTAA
TTTTTTAAAAAACACCATGCTTGGAGGGTGGGGGTAGAAATAGACACAATATTATTTCTAAGGAATCGGGTTTTCATTTACTCTGGACTG
GTGAAAATATTTTTTAAAGCCAGTGCTCTAAGACCTCAGCTTTTATCTCAGAACCCCATGGGTTCCAGACCAAGAGTACAGGAAATCAAA
TTGTTGTCCTGTCTGTCTATAGCTTGGAACAGGGAGCTTTGATTACTGACTCCGGTTCCACACACTGTAAGATCAAAAAACCATCTCCAC
ATTTGAAAGAGATGTAAGGTGTATTCATAGGGATGGTGGCTCAACAAATCAAGCAAACTGGAATCAAGGGGAGGGGGAAGGGAATGAAAT
GGAAAGGGAGGCTGATTCCCTTCCCCTGACTTACCACTAATTTACTAGGCTACCTACTTTCATGAGTAACCTCTCACAGCTACCCAGCAC
ATGCCACAATCCTATGCTCTTGCCTTCTTTTATCTGCACTGTGTGAAGGGACTCTTTTAAATAAATGAGCAAGTGTCCTAAGCTATGTCA
TCCAAAGATTGTCCTTTCCATTCTCAAATCCTGTGACTGGGATCACTCAACAGCACTGTGATGTATTATTTTCAATGAGGTGCCTTTCTT
AACTGACCAAATGCTGCCTTGTTTGGCCCCTAAATCAATAAAATATGTTAAAATTTGTATCCCCTGTTGTGGCATTTTTTTTAGATAATC
TAAGCTAGAAAAATGACATTGAATTCTGGACCTGGCTGGAAGGAAAAGAAGCCCTTTCTTGTCGCTGGCAGCTGTGTGGTAGGGAGGTCC
AAGTATGTGCATATGAGATAAGCCTGCAACCTCTTGACCTTCAGCTCCTATGCAGGCTTCTCTTGAGCCCAGAGACAAGGCAGCTTGGTC
TAGTGGAGATAGCACTGTGCTTGGAGTTCAGGGGACCTAGGACAAATCCCAGCCAGTTAGTTATTCACTGTGCTCCTGTTTCCTCAGCTG
AAAAAGGAAGTTGGTTATGCCACCTTCTTGGCCTTAATGGCATTAAATGAAATTTATAGGAAGAAGGTTTTTGCTCAGTACCTGGCATGC
AACAGACATTGGATAAATGTTAGTTGGATCCAGATATACACAGAAAGATATCTGCTTCCTGCCAGGCTGGATAACTGTTGAATGGACACT
TGTCCATAGTCTAGAAAGCCAGTGCTTCTAATCCTTAAGCCAGATCTTTGACTACCTTTTCAGTTGCTTCTTTAACACTCTTTGTTGCTT
CTCTGTGTGTCCTAGTTTAAATTCATTTCCTCTCCAGCAAAAGTGAGCTTAAATAATTTCTCCAAACTAAAGCTCTCATGTTTTTGGAAG
GGCTGCCTTTGCAAGTGAGGTTTCTGAGAAATGACTGTTGTTCCCAAAACAAGAGGGAGCTGGGCTGGAAGCACCACTATTCTTCTTTAG
GCATCTTGTTACAGAGAGAGGCAGGGTCTTCACTGACATATTAAATCCTGTTCCCTGAACCAGCCCCTCCCTCTTCTGCTCCACTTCCTC
ACCTGTGCAGAGTCATTTTCAGGTGTTAGCCTTACTGATTTGCACTGATCTGTTTGTTCCCTGAGCTTTTTAAATACCCTGTGAAAATTT
TCTTTCCTCCCTTGGTCATCATGCATCTAATTGTGGGGAAATGTTTGTCAAACCAACCTGCAAAGCAGCATGGTGTAGTTGAGAAGAATA
AACAGAGAAGACTGGGTGAGCTATTGTTTGTTTGCTTCTTTGGGCCTGGGTTTCCTCATCTAATCTGCAAACCAAGAATGCAGACTAGTC
CTACCACTCCCGGAAGACTGACGTTGTGCCAGGTATTATGCAAAGGCTTCATGTAACCCTCGACTTCACGTAACCCTCACACAGCACCCT
GTGGAGTCAGAACTGTCCTTCACTTTTATAGGTGAGGAAACCAGACTCAGAGAGGTGAAGTGGCATTCCTGAGGTCATGCATAAGAGGCA
GTCAGGACTGAAACACAGTCTCTAACACTTATCCGTCCCCTTGATCTTGTTGCTGAAGTGATTTAATTACTTGCGTAGCTCTGCACACAG
GAAGGGCTGCTCTGAATAAGAGCTCTTTTCCATGGACACTCAGCGCTGCCGGAACTGATTTTGAAGAAGTCACTGCCGGCTCTGAGGGCC
TAGGGTATGTGTCTTAGGATCTCCTGTGTGCACAAAGTGTCACTGACAGAACACAGCAGGATGGAGAGCAGCCTCCTCAGAAGCCTCACA
AGTCTTTCCTCAGATGAAGACAGAGCAACGAGTCAGAAGACAGATTTCAACAGCGACTTCACCATGCGACCTTGGACAAGTTATCTCACC
TCATCAGTAGAATAGGAATGATCCCTACCCCTCAAAGGTGCTGATGACACTAGTGACCAAGATACTCATGTGGGTTGGACTGCCCAGGAC
ACAGCAGATGCTTAGTAAACACAGATGGAATTCAGAGGGAAAATGTAGGCATTGAAGAAAGTTGTCTTACTGACCATCCGGAACCAGGCT
AAGGATCCCCTAGAAATCATAGACCTCTGAAATTATATGCAGAATTCTTTATGTGTTTTCATAATTAATAATAGTCTAACATATTAAATT

>94644_94644_1_TSNARE1-AK2_TSNARE1_chr8_143356141_ENST00000520166_AK2_chr1_33476434_ENST00000373449_length(amino acids)=504AA_BP=481
MSYGSIARGGGLGSRGPFGGPSRQGCQPLECARCWTEYGIRHFPCPSPESKLQNRCVGKDGEGDLGPAGTPIVPRARKRGPGVAPEGSRM
PEPTSSPTIGPRKDSAAGPHGRMAGPSTTRAKKRKPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEPTRRYRVWSRILQAVNALGYCRRD
VVDLKHKWRDLRAVVRRKLGDLRKAAHGPSPGSGKPQALALTPVEQVVAKTFSCQALPSEGFSLEPPRATQVDPCNLQELFQEMSANVFR
INSSVTSLERSLQSLGTPSDTQELRDSLHTAQQETNKTIAASASSVKQMAELLRSSCPERLQQERPQLDRLKTQLSDAIQCYGVVQKKIA
EKSRALLPMAQRGSKQQSPQAPFAELADDEKVFNGSDNMWQGQEQALLPDITEEDLEAIRLREEAILQMESNLLDVNQIIKDLASMVSEQ

--------------------------------------------------------------
>94644_94644_2_TSNARE1-AK2_TSNARE1_chr8_143356141_ENST00000520166_AK2_chr1_33476434_ENST00000548033_length(transcript)=1841nt_BP=1485nt
CTCAGTGTGGAGGCTGCTGGCCCTGCCATCTGTAAGAAGATGTCATACGGATCCATCGCCCGTGGAGGTGGCCTGGGGAGCCGTGGCCCT
TTCGGGGGACCTTCGAGACAAGGCTGTCAGCCCCTAGAGTGCGCTAGATGTTGGACCGAGTATGGAATCCGCCATTTCCCCTGCCCGTCG
CCAGAGAGCAAGCTGCAGAACCGCTGTGTGGGGAAGGACGGGGAAGGTGATCTGGGGCCAGCAGGCACGCCTATTGTCCCAAGGGCCAGG
AAGCGAGGGCCTGGGGTTGCCCCTGAAGGCAGCCGGATGCCGGAGCCCACCTCATCACCCACCATTGGCCCGAGGAAGGACTCGGCTGCT
GGGCCCCATGGCCGGATGGCGGGGCCCAGCACTACCCGGGCCAAGAAGAGGAAGCCCAACTTCTGCCCGCAGGAGACCGAGGTGCTGGTG
TCCAAGGTGAGCAAGCACCACCAGCTGCTGTTTGGCACGGGGCTGCTGAAGGCCGAGCCCACTCGCAGGTACCGCGTGTGGAGCCGCATC
CTGCAGGCCGTGAATGCGCTGGGCTACTGTCGCCGCGACGTTGTGGACCTGAAGCACAAGTGGCGGGACCTACGAGCCGTCGTGCGGCGC
AAGCTGGGCGACCTCCGGAAGGCGGCCCATGGCCCCAGCCCTGGTTCCGGCAAGCCCCAGGCCCTGGCTCTCACGCCCGTGGAGCAGGTG
GTGGCCAAGACCTTCTCTTGCCAGGCCCTGCCCTCCGAGGGCTTCAGTCTGGAGCCGCCCAGAGCCACCCAGGTCGATCCGTGCAACCTC
CAGGAGCTGTTCCAGGAGATGTCGGCCAACGTCTTCCGAATCAACTCCAGTGTGACCTCCTTGGAGCGGAGCCTTCAGTCCTTAGGGACA
CCGAGTGACACGCAGGAGCTTCGGGACAGCCTGCACACGGCACAGCAGGAGACCAACAAGACCATTGCAGCCAGCGCCAGCTCCGTGAAG
CAGATGGCCGAGCTGCTGCGCAGCTCCTGCCCGGAGCGTCTGCAGCAGGAGCGTCCTCAGCTGGACCGGCTGAAAACCCAGCTCTCAGAT
GCCATTCAGTGCTATGGAGTGGTGCAGAAGAAAATTGCAGAAAAGTCCAGAGCGCTGCTTCCCATGGCGCAGAGGGGCAGTAAACAGCAG
AGTCCCCAGGCCCCGTTTGCCGAGCTGGCTGATGATGAGAAGGTCTTTAACGGGAGTGACAACATGTGGCAGGGCCAGGAGCAGGCGCTG
CTCCCGGACATCACTGAAGAGGACCTGGAGGCCATCCGGCTGCGGGAGGAGGCCATCCTGCAGATGGAGAGCAACTTGCTGGATGTGAAT
CAGATCATCAAGGACTTGGCCTCCATGGTGTCAGAGCAAGGAGAAGCTGTTGATAGTATTGAAGCCAGCCTTGAGGCTGCGTCCTCGCAT
GCGGAGGCAGCCCGCCAGCTCCTGGCTGGAGCCAGCCGGCACCAACCTAGTATCAGAAGGCCAGGCGAGACTGCAACACTGCTCATCACC
CCGCGGCGTGATCCCTGCTCTTAGGTGCTGGGCAGAGGGGAAGGGTGGTCAGGGTGAGGATGGTGAGGGAGGGCTGGTGAGGGGCTCAGA
GGAATACTTGGAACAACAGCAGTGTTATTGTAGTGTGGCAGTTTCTTTTATACATAGGTGAGAGTTTTTAAAGTGTAAGGGAAAAATTAA
TTTTTTAAAAAACACCATGCTTGGAGGGTGGGGGTAGAAATAGACACAATATTATTTCTAAGGAATCGGGTTTTCATTTACTCTGGACTG

>94644_94644_2_TSNARE1-AK2_TSNARE1_chr8_143356141_ENST00000520166_AK2_chr1_33476434_ENST00000548033_length(amino acids)=504AA_BP=481
MSYGSIARGGGLGSRGPFGGPSRQGCQPLECARCWTEYGIRHFPCPSPESKLQNRCVGKDGEGDLGPAGTPIVPRARKRGPGVAPEGSRM
PEPTSSPTIGPRKDSAAGPHGRMAGPSTTRAKKRKPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEPTRRYRVWSRILQAVNALGYCRRD
VVDLKHKWRDLRAVVRRKLGDLRKAAHGPSPGSGKPQALALTPVEQVVAKTFSCQALPSEGFSLEPPRATQVDPCNLQELFQEMSANVFR
INSSVTSLERSLQSLGTPSDTQELRDSLHTAQQETNKTIAASASSVKQMAELLRSSCPERLQQERPQLDRLKTQLSDAIQCYGVVQKKIA
EKSRALLPMAQRGSKQQSPQAPFAELADDEKVFNGSDNMWQGQEQALLPDITEEDLEAIRLREEAILQMESNLLDVNQIIKDLASMVSEQ

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Fusion Gene PPI Analysis for TSNARE1-AK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TSNARE1-AK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TSNARE1-AK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource