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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TSPAN15-ASAP2 (FusionGDB2 ID:94709)

Fusion Gene Summary for TSPAN15-ASAP2

Fusion gene summary

Fusion gene information	Fusion gene name: TSPAN15-ASAP2
	Fusion gene ID: 94709
		Hgene	Tgene
	Gene symbol	TSPAN15	ASAP2
	Gene ID	23555	8853
	Gene name	tetraspanin 15	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
	Synonyms	2700063A19Rik\|NET-7\|NET7\|TM4SF15	AMAP2\|CENTB3\|DDEF2\|PAG3\|PAP\|Pap-alpha\|SHAG1
	Cytomap	10q22.1	2p25.1\|2p24
	Type of gene	protein-coding	protein-coding
	Description	tetraspanin-15tetraspan NET-7transmembrane 4 superfamily member 15transmembrane 4 superfamily member tetraspan NET-7tspan-15	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2PYK2 C terminus-associated proteincentaurin, beta 3development and differentiation-enhancing factor 2paxillin-associated protein with ARF GAP activity 3pyk2 C-terminus-associated p
	Modification date	20200313	20200327
	UniProtAcc	.	O43150
	Ensembl transtripts involved in fusion gene	ENST00000373290, ENST00000459981,	ENST00000491413, ENST00000281419, ENST00000315273,
Fusion gene scores	* DoF score	8 X 10 X 4=320	9 X 10 X 4=360
	# samples	9	11
	** MAII score	log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TSPAN15 [Title/Abstract] AND ASAP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TSPAN15(71244971)-ASAP2(9508554), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TSPAN15	GO:0045746	negative regulation of Notch signaling pathway	30463011

Fusion gene breakpoints across TSPAN15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ASAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-EQ-A4SO-01A	TSPAN15	chr10	71244971	+	ASAP2	chr2	9508554	+

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Fusion Gene ORF analysis for TSPAN15-ASAP2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000373290	ENST00000491413	TSPAN15	chr10	71244971	+	ASAP2	chr2	9508554	+
In-frame	ENST00000373290	ENST00000281419	TSPAN15	chr10	71244971	+	ASAP2	chr2	9508554	+
In-frame	ENST00000373290	ENST00000315273	TSPAN15	chr10	71244971	+	ASAP2	chr2	9508554	+
intron-3CDS	ENST00000459981	ENST00000281419	TSPAN15	chr10	71244971	+	ASAP2	chr2	9508554	+
intron-3CDS	ENST00000459981	ENST00000315273	TSPAN15	chr10	71244971	+	ASAP2	chr2	9508554	+
intron-intron	ENST00000459981	ENST00000491413	TSPAN15	chr10	71244971	+	ASAP2	chr2	9508554	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000373290

TSPAN15

chr10

71244971

ENST00000281419

ASAP2

chr2

9508554

4390

479

122

2038

638

ENST00000373290

TSPAN15

chr10

71244971

ENST00000315273

ASAP2

chr2

9508554

4260

479

122

1903

593

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000373290	ENST00000281419	TSPAN15	chr10	71244971	+	ASAP2	chr2	9508554	+	0.000961999	0.999038
ENST00000373290	ENST00000315273	TSPAN15	chr10	71244971	+	ASAP2	chr2	9508554	+	0.000823541	0.99917644

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Fusion Genomic Features for TSPAN15-ASAP2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TSPAN15	chr10	71244971	+	ASAP2	chr2	9508553	+	1.03E-06	0.9999989
TSPAN15	chr10	71244971	+	ASAP2	chr2	9508553	+	1.03E-06	0.9999989

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSPAN15-ASAP2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:71244971/chr2:9508554)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ASAP2 O43150
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. {ECO:0000269\|PubMed:10022920, ECO:0000269\|PubMed:10749932, ECO:0000269\|PubMed:11304556}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TSPAN15

chr10:71244971

chr2:9508554

ENST00000373290

1_23

119

295.0

Topological domain

Cytoplasmic

Hgene

TSPAN15

chr10:71244971

chr2:9508554

ENST00000373290

45_62

119

295.0

Topological domain

Extracellular

Hgene

TSPAN15

chr10:71244971

chr2:9508554

ENST00000373290

84_93

119

295.0

Topological domain

Cytoplasmic

Hgene

TSPAN15

chr10:71244971

chr2:9508554

ENST00000373290

24_44

119

295.0

Transmembrane

Helical

Hgene

TSPAN15

chr10:71244971

chr2:9508554

ENST00000373290

63_83

119

295.0

Transmembrane

Helical

Hgene

TSPAN15

chr10:71244971

chr2:9508554

ENST00000373290

94_114

119

295.0

Transmembrane

Helical

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000281419

729_752

487

1007.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000315273

729_752

487

962.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000281419

771_936

487

1007.0

Compositional bias

Note=Pro-rich

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000315273

771_936

487

962.0

Compositional bias

Note=Pro-rich

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000281419

944_1006

487

1007.0

Domain

SH3

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000315273

944_1006

487

962.0

Domain

SH3

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000281419

584_616

487

1007.0

Repeat

Note=ANK 1

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000281419

620_649

487

1007.0

Repeat

Note=ANK 2

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000315273

584_616

487

962.0

Repeat

Note=ANK 1

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000315273

620_649

487

962.0

Repeat

Note=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TSPAN15

chr10:71244971

chr2:9508554

ENST00000373290

115_235

119

295.0

Topological domain

Extracellular

Hgene

TSPAN15

chr10:71244971

chr2:9508554

ENST00000373290

257_294

119

295.0

Topological domain

Cytoplasmic

Hgene

TSPAN15

chr10:71244971

chr2:9508554

ENST00000373290

236_256

119

295.0

Transmembrane

Helical

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000281419

256_283

487

1007.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000315273

256_283

487

962.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000281419

305_397

487

1007.0

Domain

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000281419

421_543

487

1007.0

Domain

Arf-GAP

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000315273

305_397

487

962.0

Domain

Tgene

ASAP2

chr10:71244971

chr2:9508554

ENST00000315273

421_543

487

962.0

Domain

Arf-GAP

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Fusion Gene Sequence for TSPAN15-ASAP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>94709_94709_1_TSPAN15-ASAP2_TSPAN15_chr10_71244971_ENST00000373290_ASAP2_chr2_9508554_ENST00000281419_length(transcript)=4390nt_BP=479nt
CGGAGAGAACGCCGGTGGCGGGGCTGGTAGCCCGGCAGCCGCAGGTGGGGCCACGAGCGCTGGCTGAGGGACCGAGCCGGAGAGCCCCGG
AGCCCCCGTAACCCGCGCGGGGAGCGCCCAGGATGCCGCGCGGGGACTCGGAGCAGGTGCGCTACTGCGCGCGCTTCTCCTACCTCTGGC
TCAAGTTTTCACTTATCATCTATTCCACCGTGTTCTGGCTGATTGGGGCCCTGGTCCTGTCTGTGGGCATCTATGCAGAGGTTGAGCGGC
AGAAATATAAAACCCTTGAAAGTGCCTTCCTGGCTCCAGCCATCATCCTCATCCTCCTGGGCGTCGTCATGTTCATGGTCTCCTTCATTG
GTGTGCTGGCGTCCCTCCGTGACAACCTGTACCTTCTCCAAGCATTCATGTACATCCTTGGGATCTGCCTCATCATGGAGCTCATTGGTG
GCGTGGTGGCCTTGACCTTCCGGAACCAGCTCGCCAAGAATATTGGGAATGCAGGCTTTAATGAGATCATGGAATGTTGCCTACCAGCTG
AGGACTCAGTCAAACCCAACCCAGGCAGCGACATGAATGCAAGAAAGGACTACATCACAGCCAAGTACATCGAGAGGAGATACGCAAGGA
AGAAGCACGCGGATAACGCGGCGAAGCTTCACAGTCTTTGCGAGGCCGTCAAAACGAGAGATATTTTTGGATTGCTCCAAGCTTATGCTG
ATGGTGTGGATCTTACGGAAAAAATCCCACTGGCCAACGGACATGAGCCGGATGAAACGGCCCTCCACCTTGCAGTCAGATCCGTGGATC
GAACCTCTCTTCACATTGTAGACTTTTTAGTTCAGAACAGTGGGAACCTGGATAAACAGACAGGGAAAGGCAGCACAGCCCTGCACTACT
GCTGCCTGACCGACAATGCCGAGTGCCTCAAGTTGCTCCTGCGGGGGAAGGCCTCCATCGAGATAGCAAACGAGTCAGGAGAGACTCCGC
TGGACATTGCCAAGCGCCTCAAGCACGAGCACTGTGAGGAGCTGCTGACCCAAGCCTTATCTGGAAGATTTAATTCTCACGTTCACGTTG
AATATGAATGGCGACTACTCCACGAAGACCTGGATGAAAGTGATGACGACATGGATGAGAAATTGCAGCCCAGTCCCAACCGGCGGGAAG
ACCGGCCCATCAGCTTCTACCAGCTGGGCTCCAACCAGCTTCAGTCTAACGCTGTATCTTTGGCCAGAGATGCTGCAAACCTTGCCAAGG
AGAAGCAGAGGGCTTTCATGCCCAGCATCTTGCAGAATGAGACTTACGGAGCCCTCCTGAGTGGCAGCCCACCTCCCGCCCAGCCTGCAG
CCCCCAGCACCACCAGCGCCCCCCCGCTTCCTCCACGGAATGTTGGCAAAGTTCAGACAGCCTCCTCTGCTAACACCCTGTGGAAGACAA
ACTCTGTAAGTGTGGACGGTGGAAGCCGGCAGCGATCTTCGTCAGATCCGCCAGCTGTCCATCCACCGCTGCCCCCTCTTCGCGTGACAT
CTACCAATCCCCTGACCCCCACGCCGCCCCCACCCGTTGCCAAGACGCCCAGCGTAATGGAAGCCTTGAGCCAGCCGAGCAAGCCTGCCC
CGCCTGGGATCTCACAGATCAGGCCCCCACCTCTGCCCCCACAGCCGCCCAGCCGCCTCCCGCAGAAGAAGCCTGCGCCGGGGGCTGACA
AGTCCACCCCACTGACCAACAAAGGCCAACCGAGAGGACCTGTGGATCTCTCTGCAACGGAAGCTCTGGGTCCTCTGTCCAATGCTATGG
TCCTGCAGCCCCCTGCACCCATGCCTAGGAAGTCGCAGGCAACCAAGTTGAAGCCTAAGCGGGTGAAAGCGCTCTATAACTGTGTGGCTG
ACAACCCCGATGAGCTCACCTTCTCCGAGGGGGATGTGATCATCGTGGACGGGGAGGAGGACCAGGAGTGGTGGATTGGCCACATTGATG
GAGATCCTGGTCGCAAAGGCGCATTCCCGGTGTCATTTGTGCACTTTATCGCTGACTGAATTGCTACTGAACAAAAGCATTAACAGTTAT
GTTCCTGTTTCGTTATTGGTACCAAAACTCTTGCCAGATAACCAGTTTCATGAACTGTTTGTATGGCAGCCCATGTTCTCTAATGCCACT
GCTCTGTTTTAAAAACTCAGAGGCAATTTTTACATATCAGTAATTGTTTTTATAATTTGTGGTTTTCATGAAACATTGCTATGCATTTAT
TAGGAAAAACTGAATTTCCCAACAGGTGAACTGAAAAGTTATTTTAACTATTATACATAATCAAGATCCTGCCTCTACGGAATTAGCTAA
ACCTAAAAATGTTTGCATTAATGAATAAATTCTTCCTGCATTCCTTGGCCCAGTTCTGGAGTTGGTGACCTTTATCACAATTATTATTTT
AGGCGGCCAGTGAACTGCTGCTTCAGAAGTCCATAGCCCAGCTCTGAACTTTCTCGATAAAATGCCATCAGTTCACCTTTAAAGACACAC
ATTCCTTTGAAATCCACCCAGTGTTTAAAAAGCAACTTGGAAATTTACACATTAGCATTGTACTTTCTAGCCCTAATTTGTGAGGTTGCA
GCTATCATTATATTCTGCATGTATGTATAACCTGTTGTGAACAATCATACTTAACAAAACTACTGATGGTTTATGACAACGTAGGGTAAC
TACAGTTCATTCTGTTCCAGGTTATATAAAACTGCATTTCCTGAATTTGGTTAAAAACTAAGGATGATGGATTGCAAAACAGTTCTTTTA
AATTAGTTTATATGCTTTAGGTGTTTTGGAATTTGCCTTCTTGAACTTCCTGAGTCACACAGAAAGCAACTGTACACAGTAGAATTCTGT
GGCGCAGACCATGCTGTATTAACACATCACTTGCTGTTTCCTACTGAGTGTACCACTGCCTTCCCTTCTAGCCCAGGAGAATGTTTACTC
AGTTTAGTGTCTTGTATTTCTATAATACTCCAACAGGAATGGTAGTCACACTGTCTTGAAATTGAATCTGTCCATCTGTTTATAATCAAG
AACATATCAGAAATATATAGGTCCCAGGTAATACTCCCAAACATCCCACTTTTTACTGTTTCAGGCCATCATATCATTCTTAAGCTACTT
GGGGTGGTAGTAGAGGATTAGGTTGTCTATTATAAAACCAAAACTCATTCGTTTAATGAACTTGACTGTCATACCTCTATTTAGTAATTG
CGAGGGTAAGATTCATAGTAGGAATATTGGAAATTTTGGCACTCTGAGAATAAATAGGCATATGATACCCACTTGGACTTTTAACAAAAG
TAAAGGAATAAATTTGCATATAGGCTTGGAAAGTGAGGCAGCAATGCTGTTAACTGCATTTGTTGTGATGGTGCATTTGATTGAAGCAGC
TTGTCTTTATTATGCAAGACTGTGTAGAGTTTTTTTTTTTTTTGGCATTGTACTTTTTGTTTTTGTTATAAAGGAAGACAGAACAAACTG
GAATGTTTTATGATGTTGTATAGCAATCGCTTTTTACCTTTCAAAGTTCCGGGTAAAAATGTGTTATATCTGTAGTTTTTTGTTTTTGTT
TTTTTTTAAAGCACTACATCTGTTTTCACTAATTGTTAATTTCTGTTTGAACCCTTCATTTAATTTTCTCATAGATTTAAGTAAACAGAT
GTATTTTGCACAGTGCACTTATGTCTATTTTAACAATCCTCCTGCATCTGTATTTTATAGTCAGCCTTTTGACCACCTGGTGCCAGCTAT
ATAAGGAATAAAGTTGATTCATATCAACATTAGAACTCCAGTCCCAAACTAATCTGTCAGGTTCACTGGTACATAAATACCTAGGAAATA
TTTTTCCAGTCTACAATTTGGTGCTATTGTGCAGTAACTAATAGTACTCTTACCAGAGGAGAAATTATATTAACGACCCTGCTAATATCC
TTTCTTAGTTATTTGCTCCTTGCAAATTAAAAAAGCAACTAAGAGAAAGAAAAACATTGTAGATATCTATTTATATTTAAAGTTTATGTT
TCATGAACTGCAGCTGCAGGATTCTGGCATTTTGCATGCCATTCTCCATCAGATCTGGGATGATGGCTCAGAACATGTACACAGACTAAG
AGTAACTGTGTGATCTGTTAAGGGGTGGATAACATAATATGCAGCTTAGGATGCTATTTTGAGATGTATGATATTCAGTTCATTCACCTG
ATTACTTTGGTTGCAGCACAACTGTATATATTGTATAACCGAAATTGATTATTTTCATTGTCCTTAATGCAGTGATTTATAATTAGAGCA

>94709_94709_1_TSPAN15-ASAP2_TSPAN15_chr10_71244971_ENST00000373290_ASAP2_chr2_9508554_ENST00000281419_length(amino acids)=638AA_BP=118
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWLIGALVLSVGIYAEVERQKYKTLESAFLAPAIILILLGVVMFMVSFIGVLASLRDNLY
LLQAFMYILGICLIMELIGGVVALTFRNQLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLH
SLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLK
LLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRPISFYQLGS
NQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQ
RSSSDPPAVHPPLPPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKSTPLTNKGQP
RGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPV

--------------------------------------------------------------
>94709_94709_2_TSPAN15-ASAP2_TSPAN15_chr10_71244971_ENST00000373290_ASAP2_chr2_9508554_ENST00000315273_length(transcript)=4260nt_BP=479nt
CGGAGAGAACGCCGGTGGCGGGGCTGGTAGCCCGGCAGCCGCAGGTGGGGCCACGAGCGCTGGCTGAGGGACCGAGCCGGAGAGCCCCGG
AGCCCCCGTAACCCGCGCGGGGAGCGCCCAGGATGCCGCGCGGGGACTCGGAGCAGGTGCGCTACTGCGCGCGCTTCTCCTACCTCTGGC
TCAAGTTTTCACTTATCATCTATTCCACCGTGTTCTGGCTGATTGGGGCCCTGGTCCTGTCTGTGGGCATCTATGCAGAGGTTGAGCGGC
AGAAATATAAAACCCTTGAAAGTGCCTTCCTGGCTCCAGCCATCATCCTCATCCTCCTGGGCGTCGTCATGTTCATGGTCTCCTTCATTG
GTGTGCTGGCGTCCCTCCGTGACAACCTGTACCTTCTCCAAGCATTCATGTACATCCTTGGGATCTGCCTCATCATGGAGCTCATTGGTG
GCGTGGTGGCCTTGACCTTCCGGAACCAGCTCGCCAAGAATATTGGGAATGCAGGCTTTAATGAGATCATGGAATGTTGCCTACCAGCTG
AGGACTCAGTCAAACCCAACCCAGGCAGCGACATGAATGCAAGAAAGGACTACATCACAGCCAAGTACATCGAGAGGAGATACGCAAGGA
AGAAGCACGCGGATAACGCGGCGAAGCTTCACAGTCTTTGCGAGGCCGTCAAAACGAGAGATATTTTTGGATTGCTCCAAGCTTATGCTG
ATGGTGTGGATCTTACGGAAAAAATCCCACTGGCCAACGGACATGAGCCGGATGAAACGGCCCTCCACCTTGCAGTCAGATCCGTGGATC
GAACCTCTCTTCACATTGTAGACTTTTTAGTTCAGAACAGTGGGAACCTGGATAAACAGACAGGGAAAGGCAGCACAGCCCTGCACTACT
GCTGCCTGACCGACAATGCCGAGTGCCTCAAGTTGCTCCTGCGGGGGAAGGCCTCCATCGAGATAGCAAACGAGTCAGGAGAGACTCCGC
TGGACATTGCCAAGCGCCTCAAGCACGAGCACTGTGAGGAGCTGCTGACCCAAGCCTTATCTGGAAGATTTAATTCTCACGTTCACGTTG
AATATGAATGGCGACTACTCCACGAAGACCTGGATGAAAGTGATGACGACATGGATGAGAAATTGCAGCCCAGTCCCAACCGGCGGGAAG
ACCGGCCCATCAGCTTCTACCAGCTGGGCTCCAACCAGCTTCAGTCTAACGCTGTATCTTTGGCCAGAGATGCTGCAAACCTTGCCAAGG
AGAAGCAGAGGGCTTTCATGCCCAGCATCTTGCAGAATGAGACTTACGGAGCCCTCCTGAGTGGCAGCCCACCTCCCGCCCAGCCTGCAG
CCCCCAGCACCACCAGCGCCCCCCCGCTTCCTCCACGGAATGTTGGCAAAGATCCCCTGACCCCCACGCCGCCCCCACCCGTTGCCAAGA
CGCCCAGCGTAATGGAAGCCTTGAGCCAGCCGAGCAAGCCTGCCCCGCCTGGGATCTCACAGATCAGGCCCCCACCTCTGCCCCCACAGC
CGCCCAGCCGCCTCCCGCAGAAGAAGCCTGCGCCGGGGGCTGACAAGTCCACCCCACTGACCAACAAAGGCCAACCGAGAGGACCTGTGG
ATCTCTCTGCAACGGAAGCTCTGGGTCCTCTGTCCAATGCTATGGTCCTGCAGCCCCCTGCACCCATGCCTAGGAAGTCGCAGGCAACCA
AGTTGAAGCCTAAGCGGGTGAAAGCGCTCTATAACTGTGTGGCTGACAACCCCGATGAGCTCACCTTCTCCGAGGGGGATGTGATCATCG
TGGACGGGGAGGAGGACCAGGAGTGGTGGATTGGCCACATTGATGGAGATCCTGGTCGCAAAGGCGCATTCCCGGTGTCATTTGTGCACT
TTATCGCTGACTGAATTGCTACTGAACAAAAGCATTAACAGTTATGTTCCTGTTTCGTTATTGGTACCAAAACTCTTGCCAGATAACCAG
TTTCATGAACTGTTTGTATGGCAGCCCATGTTCTCTAATGCCACTGCTCTGTTTTAAAAACTCAGAGGCAATTTTTACATATCAGTAATT
GTTTTTATAATTTGTGGTTTTCATGAAACATTGCTATGCATTTATTAGGAAAAACTGAATTTCCCAACAGGTGAACTGAAAAGTTATTTT
AACTATTATACATAATCAAGATCCTGCCTCTACGGAATTAGCTAAACCTAAAAATGTTTGCATTAATGAATAAATTCTTCCTGCATTCCT
TGGCCCAGTTCTGGAGTTGGTGACCTTTATCACAATTATTATTTTAGGCGGCCAGTGAACTGCTGCTTCAGAAGTCCATAGCCCAGCTCT
GAACTTTCTCGATAAAATGCCATCAGTTCACCTTTAAAGACACACATTCCTTTGAAATCCACCCAGTGTTTAAAAAGCAACTTGGAAATT
TACACATTAGCATTGTACTTTCTAGCCCTAATTTGTGAGGTTGCAGCTATCATTATATTCTGCATGTATGTATAACCTGTTGTGAACAAT
CATACTTAACAAAACTACTGATGGTTTATGACAACGTAGGGTAACTACAGTTCATTCTGTTCCAGGTTATATAAAACTGCATTTCCTGAA
TTTGGTTAAAAACTAAGGATGATGGATTGCAAAACAGTTCTTTTAAATTAGTTTATATGCTTTAGGTGTTTTGGAATTTGCCTTCTTGAA
CTTCCTGAGTCACACAGAAAGCAACTGTACACAGTAGAATTCTGTGGCGCAGACCATGCTGTATTAACACATCACTTGCTGTTTCCTACT
GAGTGTACCACTGCCTTCCCTTCTAGCCCAGGAGAATGTTTACTCAGTTTAGTGTCTTGTATTTCTATAATACTCCAACAGGAATGGTAG
TCACACTGTCTTGAAATTGAATCTGTCCATCTGTTTATAATCAAGAACATATCAGAAATATATAGGTCCCAGGTAATACTCCCAAACATC
CCACTTTTTACTGTTTCAGGCCATCATATCATTCTTAAGCTACTTGGGGTGGTAGTAGAGGATTAGGTTGTCTATTATAAAACCAAAACT
CATTCGTTTAATGAACTTGACTGTCATACCTCTATTTAGTAATTGCGAGGGTAAGATTCATAGTAGGAATATTGGAAATTTTGGCACTCT
GAGAATAAATAGGCATATGATACCCACTTGGACTTTTAACAAAAGTAAAGGAATAAATTTGCATATAGGCTTGGAAAGTGAGGCAGCAAT
GCTGTTAACTGCATTTGTTGTGATGGTGCATTTGATTGAAGCAGCTTGTCTTTATTATGCAAGACTGTGTAGAGTTTTTTTTTTTTTTGG
CATTGTACTTTTTGTTTTTGTTATAAAGGAAGACAGAACAAACTGGAATGTTTTATGATGTTGTATAGCAATCGCTTTTTACCTTTCAAA
GTTCCGGGTAAAAATGTGTTATATCTGTAGTTTTTTGTTTTTGTTTTTTTTTAAAGCACTACATCTGTTTTCACTAATTGTTAATTTCTG
TTTGAACCCTTCATTTAATTTTCTCATAGATTTAAGTAAACAGATGTATTTTGCACAGTGCACTTATGTCTATTTTAACAATCCTCCTGC
ATCTGTATTTTATAGTCAGCCTTTTGACCACCTGGTGCCAGCTATATAAGGAATAAAGTTGATTCATATCAACATTAGAACTCCAGTCCC
AAACTAATCTGTCAGGTTCACTGGTACATAAATACCTAGGAAATATTTTTCCAGTCTACAATTTGGTGCTATTGTGCAGTAACTAATAGT
ACTCTTACCAGAGGAGAAATTATATTAACGACCCTGCTAATATCCTTTCTTAGTTATTTGCTCCTTGCAAATTAAAAAAGCAACTAAGAG
AAAGAAAAACATTGTAGATATCTATTTATATTTAAAGTTTATGTTTCATGAACTGCAGCTGCAGGATTCTGGCATTTTGCATGCCATTCT
CCATCAGATCTGGGATGATGGCTCAGAACATGTACACAGACTAAGAGTAACTGTGTGATCTGTTAAGGGGTGGATAACATAATATGCAGC
TTAGGATGCTATTTTGAGATGTATGATATTCAGTTCATTCACCTGATTACTTTGGTTGCAGCACAACTGTATATATTGTATAACCGAAAT
TGATTATTTTCATTGTCCTTAATGCAGTGATTTATAATTAGAGCATGTTTAATAAGTTTACTCTTCTTGTTAACTAGTCATTTGACTGGA

>94709_94709_2_TSPAN15-ASAP2_TSPAN15_chr10_71244971_ENST00000373290_ASAP2_chr2_9508554_ENST00000315273_length(amino acids)=593AA_BP=118
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWLIGALVLSVGIYAEVERQKYKTLESAFLAPAIILILLGVVMFMVSFIGVLASLRDNLY
LLQAFMYILGICLIMELIGGVVALTFRNQLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLH
SLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLK
LLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRPISFYQLGS
NQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKDPLTPTPPPPVAKTPSVMEALSQP
SKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALY

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Fusion Gene PPI Analysis for TSPAN15-ASAP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TSPAN15-ASAP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TSPAN15-ASAP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source