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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TSPAN17-SFXN1 (FusionGDB2 ID:94721)

Fusion Gene Summary for TSPAN17-SFXN1

Fusion gene summary

Fusion gene information	Fusion gene name: TSPAN17-SFXN1
	Fusion gene ID: 94721
		Hgene	Tgene
	Gene symbol	TSPAN17	SFXN1
	Gene ID	26262	94081
	Gene name	tetraspanin 17	sideroflexin 1
	Synonyms	FBX23\|FBXO23\|TM4SF17	SLC56A1\|TCC
	Cytomap	5q35.2	5q35.2
	Type of gene	protein-coding	protein-coding
	Description	tetraspanin-17F-box only protein 23, transmembrane 4 superfamily member 17tetraspan protein SB134	sideroflexin-1tricarboxylate carrier protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000298564, ENST00000310032, ENST00000503045, ENST00000508164, ENST00000405525, ENST00000515708,	ENST00000502393, ENST00000515791, ENST00000321442,
Fusion gene scores	* DoF score	1 X 1 X 1=1	6 X 6 X 4=144
	# samples	1	7
	** MAII score	log2(1/1*10)=3.32192809488736	log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TSPAN17 [Title/Abstract] AND SFXN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TSPAN17(176083957)-SFXN1(174938454), # samples:2
Anticipated loss of major functional domain due to fusion event.	TSPAN17-SFXN1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TSPAN17	GO:0072594	establishment of protein localization to organelle	23091066
Tgene	SFXN1	GO:0006730	one-carbon metabolic process	30442778
Tgene	SFXN1	GO:0015825	L-serine transport	30442778
Tgene	SFXN1	GO:0042942	D-serine transport	30442778

Fusion gene breakpoints across TSPAN17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SFXN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-23-1032-01A	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+

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Fusion Gene ORF analysis for TSPAN17-SFXN1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000298564	ENST00000502393	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
5CDS-intron	ENST00000298564	ENST00000515791	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
5CDS-intron	ENST00000310032	ENST00000502393	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
5CDS-intron	ENST00000310032	ENST00000515791	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
5CDS-intron	ENST00000503045	ENST00000502393	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
5CDS-intron	ENST00000503045	ENST00000515791	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
5CDS-intron	ENST00000508164	ENST00000502393	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
5CDS-intron	ENST00000508164	ENST00000515791	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
Frame-shift	ENST00000298564	ENST00000321442	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
In-frame	ENST00000310032	ENST00000321442	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
In-frame	ENST00000503045	ENST00000321442	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
In-frame	ENST00000508164	ENST00000321442	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
intron-3CDS	ENST00000405525	ENST00000321442	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
intron-3CDS	ENST00000515708	ENST00000321442	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
intron-intron	ENST00000405525	ENST00000502393	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
intron-intron	ENST00000405525	ENST00000515791	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
intron-intron	ENST00000515708	ENST00000502393	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+
intron-intron	ENST00000515708	ENST00000515791	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000310032

TSPAN17

chr5

176083957

ENST00000321442

SFXN1

chr5

174938454

4590

1047

178

1581

467

ENST00000508164

TSPAN17

chr5

176083957

ENST00000321442

SFXN1

chr5

174938454

4466

923

1457

464

ENST00000503045

TSPAN17

chr5

176083957

ENST00000321442

SFXN1

chr5

174938454

4347

804

1338

444

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000310032	ENST00000321442	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+	0.001633962	0.99836606
ENST00000508164	ENST00000321442	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+	0.001528407	0.99847156
ENST00000503045	ENST00000321442	TSPAN17	chr5	176083957	+	SFXN1	chr5	174938454	+	0.000583545	0.9994165

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Fusion Genomic Features for TSPAN17-SFXN1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TSPAN17	chr5	176083957	+	SFXN1	chr5	174938453	+	0.003605632	0.99639434
TSPAN17	chr5	176083957	+	SFXN1	chr5	174938453	+	0.003605632	0.99639434

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSPAN17-SFXN1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176083957/chr5:174938454)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000508164

116_234

269

330.0

Topological domain

Extracellular

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000508164

1_19

269

330.0

Topological domain

Cytoplasmic

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000508164

256_270

269

330.0

Topological domain

Cytoplasmic

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000508164

41_63

269

330.0

Topological domain

Extracellular

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000508164

85_94

269

330.0

Topological domain

Cytoplasmic

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000508164

20_40

269

330.0

Transmembrane

Helical

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000508164

235_255

269

330.0

Transmembrane

Helical

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000508164

64_84

269

330.0

Transmembrane

Helical

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000508164

95_115

269

330.0

Transmembrane

Helical

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

168_174

144

323.0

Topological domain

Mitochondrial matrix

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

196_228

144

323.0

Topological domain

Mitochondrial intermembrane

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

250_266

144

323.0

Topological domain

Mitochondrial matrix

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

288_322

144

323.0

Topological domain

Mitochondrial intermembrane

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

147_167

144

323.0

Transmembrane

Helical

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

175_195

144

323.0

Transmembrane

Helical

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

229_249

144

323.0

Transmembrane

Helical

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

267_287

144

323.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000298564

116_234

189.0

Topological domain

Extracellular

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000298564

1_19

189.0

Topological domain

Cytoplasmic

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000298564

256_270

189.0

Topological domain

Cytoplasmic

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000298564

41_63

189.0

Topological domain

Extracellular

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000298564

85_94

189.0

Topological domain

Cytoplasmic

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000515708

116_234

264.0

Topological domain

Extracellular

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000515708

1_19

264.0

Topological domain

Cytoplasmic

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000515708

256_270

264.0

Topological domain

Cytoplasmic

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000515708

41_63

264.0

Topological domain

Extracellular

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000515708

85_94

264.0

Topological domain

Cytoplasmic

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000298564

20_40

189.0

Transmembrane

Helical

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000298564

235_255

189.0

Transmembrane

Helical

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000298564

64_84

189.0

Transmembrane

Helical

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000298564

95_115

189.0

Transmembrane

Helical

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000515708

20_40

264.0

Transmembrane

Helical

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000515708

235_255

264.0

Transmembrane

Helical

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000515708

64_84

264.0

Transmembrane

Helical

Hgene

TSPAN17

chr5:176083957

chr5:174938454

ENST00000515708

95_115

264.0

Transmembrane

Helical

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

121_146

144

323.0

Topological domain

Mitochondrial intermembrane

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

2_102

144

323.0

Topological domain

Mitochondrial matrix

Tgene

SFXN1

chr5:176083957

chr5:174938454

ENST00000321442

103_120

144

323.0

Transmembrane

Helical

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Fusion Gene Sequence for TSPAN17-SFXN1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>94721_94721_1_TSPAN17-SFXN1_TSPAN17_chr5_176083957_ENST00000310032_SFXN1_chr5_174938454_ENST00000321442_length(transcript)=4590nt_BP=1047nt
GGCGGGGCCCGGTCCAGAGGCGGGGACAGCAGGGCTCCGGGCAAGGAGGTCTGGATGCTGAGGGCGGTCCCTGAGGGGCGGGCGGGGCCC
GACCGGCGCTCTGTGTGGCCGAGGCCATGAAGCCGCAGCCGCCCGGCTAGGCCCCGGGCGGCTCTAGCCCAGGGCGGCCCGCGGGGCGCT
GGGCCTGGCTCCCGGCTCCGGTTTCCGGGCCGGCGGGTGGCCGCTCACCATGCCCGGCAAGCACCAGCATTTCCAGGAACCTGAGGTCGG
CTGCTGCGGGAAATACTTCCTGTTTGGCTTCAACATTGTCTTCTGGGTGCTGGGAGCCCTGTTCCTGGCTATCGGCCTCTGGGCCTGGGG
TGAGAAGGGCGTTCTCTCGAACATCTCAGCGCTGACAGATCTGGGAGGCCTTGACCCCGTGTGGCTGTTTGTGGTAGTTGGAGGCGTCAT
GTCGGTGCTGGGCTTTGCTGGCTGCATTGGGGCCCTCCGGGAGAACACCTTCCTGCTCAAGTTTTTCTCCGTGTTCCTCGGTCTCATCTT
CTTCCTGGAGCTGGCAACAGGGATCCTGGCCTTTGTCTTCAAGGACTGGATTCGAGACCAGCTCAACCTCTTCATCAACAACAACGTCAA
GGCCTACCGGGACGACATTGACCTCCAGAACCTCATTGACTTTGCTCAGGAATACTGGTCTTGCTGCGGAGCCCGAGGCCCCAATGACTG
GAACCTCAATATCTACTTCAACTGCACTGACTTGAACCCCAGCCGGGAGCGCTGCGGGGTGCCCTTCTCCTGCTGCGTCAGGGACCCTGC
GGAGGATGTCCTCAACACCCAGTGTGGCTACGACGTCCGGCTCAAACTGGTGAGAGGGGAGCTGGAGCAGCAGGGCTTCATCCACACCAA
AGGCTGCGTGGGCCAGTTTGAGAAGTGGCTGCAGGACAACCTGATTGTGGTGGCGGGAGTCTTCATGGGCATCGCCCTCCTCCAGATCTT
TGGCATCTGCCTGGCCCAGAACCTCGTGAGTGACATCAAGGCAGTGAAAGCCAACTGTGAGTTGGGAACAGCTTACGTTTCTGCAACAAC
TGGTGCCGTAGCAACAGCTCTAGGACTCAATGCATTGACCAAGCATGTCTCACCACTGATAGGACGTTTTGTTCCCTTTGCTGCCGTAGC
TGCTGCTAATTGCATTAATATTCCATTAATGAGGCAAAGGGAACTCAAAGTTGGCATTCCCGTCACGGATGAGAATGGGAACCGCTTGGG
GGAGTCGGCGAACGCTGCGAAACAAGCCATCACGCAAGTTGTCGTGTCCAGGATTCTCATGGCAGCCCCTGGCATGGCCATCCCTCCATT
CATTATGAACACTTTGGAAAAGAAAGCCTTTTTGAAGAGGTTCCCATGGATGAGTGCACCCATTCAAGTTGGGTTAGTTGGCTTCTGTTT
GGTGTTTGCTACACCCCTGTGTTGTGCCCTGTTTCCTCAGAAAAGTTCCATGTCTGTGACAAGCTTGGAGGCCGAGTTGCAAGCTAAGAT
CCAAGAGAGCCATCCTGAATTGCGACGCGTGTACTTCAATAAGGGATTGTAAAGCAGGGAGGAAACCTCTGCAGCTCATTCTGCCACTGC
AAAGCTGGTGTAGCCATGCTGGTGAGAAAAATCCTGTTCAACCTGGGTTCTCCCAGTTACGGAAACCTTTTAAAGATCCACATTAGCCTT
TTAGAATAAAGCTGCTACTTTAACAGAGCACCTGGCGTGGGCCAAGTGCCTGATACTCCCTTACACTGAATCATGTTATGATTTATAGAA
ATACCTTTCCTGTAGCTTTTATAGTCATTGTTTTTCAAAGACGATATACCAGCCCTCACCCAGGTTTTAAAAAAGCACTGGTAGGCATAG
AATAGGTGCTCAGTATATGGTCAGTAAATGTTCTATTGATTATCAATCAGTGAAAAAAGAAATCTGTTTAAAATACTGAATTTTCATCTC
ACTCCCATTGCAAATCAAGGAGATCTCAGCAGTGAACTGGGAAAATACAAAAGCTCTGGGCTAATCTATAAAAACTTACCCTGAAATATT
AAGGGCAGTTTGCTTCTAGTTTGGGGATTGCGCTAGCCCAATGAAGGTGATGAAGCTTTTGGATTTGGAGGGTAAAAGCTCCTTCACACC
CCTTCCAAAAGTCAGTCACAGACCACTGCAACATGCCTTCCCTGCTGGATCATTATATACATTCAGATTGTGAGTGGATTGCCTTGGTTG
ACTTTTAATTTATTGTTTTTTGTTCTTATAAAGATGATAATCTTACCTTGCAGTTATTGACTTTATATTCAATTATTTACATCAAATAAT
GAAATAACTGAAATGTACAAATGTCAAATTTTGGAAGTATATTCAATACCAATGCTGTATGAGTGGGCTGAATCCAGTTCATTGTTTTTT
TTTTGGTAAGAAGTGAGACTACAGTTCCAGCTACCTACATGTCTTTTCTTGTCATCCTTATAGATCTCTTTGGCTTTCAGAAAGATACAG
TGATAATGTGTGTATGAATCAGTCACAATGAATTTTACTTGAATATTGTATGTTGCATTCCACTTCATTTGAAAATAATGAAACCATGTA
CCACTGTTTACATCATCTGTAGTGATTTCATAGATAATATATTTAATATGACAGATTATGTTTCAACTCTGTAGATGTTTAACGTCATAG
ACAGTTGGCCCTCTGTATCCGTGAGCTCTATATCTGTGAATTCAACCAAGTTTGGATGGAAAATTTTTTTTTTTTTTTTTTTTTTGAGAC
GGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTAGTCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCGTTCTCCTG
CCTCAGCCTCTCTGAGAAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACT
GTGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTTGGCCTCCCAAGGTGCTGGGATTACAAGCGTGAGCCACCGCACCCGGCCTGAA
AATATTTTCTAAAAAGATAAAAAATATACATAACGATGAAAAATAATACAAATTTAAAAACCAATACAGTATAACAACTATTTACATAGT
GCTTACATTGTATTAGGTGTTATAAGCAATCTAGAGATGATTTAGCAAGTATACAGGAGGATGTGCCTAGGTTATATGCAAATACTGTGC
CATTTTATATCAGGAACTTGAGCATCTGCAGATATTGGTATCGGAGGGCGGTCCTGGAACCAAGCATCCACGGATACTGAGGGGTGACAT
TTCATGAAGTGTAGATCATTGTATTCAGAGATTGTAAATGAAAAAAATATAGAAACTATTTAGTTTTGGTAGATTTTTTTTCTGACAATG
TGACCAGACTGAATTTCCTCATAAAGAAAAAATGGCGTGCCTTGTGTCTGTGTTTCTCTTTTCTCTGAAAGGATTAATAGATCTGAAGCT
TTGGGCCACTCAGAGCCTTCCTTGATGCTGCCAGAGTCTTCTTATTTAGATTTTCTGTCTTAAACCATTGGAAGCAAAACGGTTTTCCCA
TGACATTCTGGCCTTGGACAGATTCTGTTGTCCTCGACGCGTCTCTTTATAAAGTGGTAAAAGCCTGAAATTCAGGGCAGCTCTCCATGA
GGTGCTGAAGGGCTCTTTTCATAAGAAGCTAAGGCACTGCTGCCTGCCCCAGGTGTCCCGCTCCTCTCAGAGTCCTCCCCCTACCAGGTA
GTGTGTAGCTCCATTTCAGAATGTTAACCTCCAGTGAAGAGCTAATGACTGGTTAGAAGATTGACAAACTAACCAAAATTTTACACACTC
CGGTTATGTGTGTGAAAGGTTATAAAAGGAATGGCCGGGTGCGGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTG
GATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGAGAAACCCCGCCTCTACTAAAAATACAAAAAATTAGCCAGGCATGG
AGGCACATGCCTATAATCCCAGCTACTCGGGAGGCTGAGGTAGGAGAATCGCTTGAATCCGGGAGCTGGAGGTTGCAGTGAGCCAAGATC
GCACCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAGAGATTATAAAAGGGATGATGAACATGGAG
CTGCATCTTTTTAAACGTTGTTTTTTGATGCTTCAGACTCTTAATGCTTTTATATAAAGCTATCAACTGTATGTTGATCACAGTTTATAA
GAAAGAACAAATCAAGATTGGCAATCCTTGCCGATCTTTTAGAAATACCTTTTCTGGAGAAAAAAAAATCCACATGAAGTGCAATAAGCT
TATAAAGCTAAGTAGTTATTAATATTTCTATTAACATGATACAAAGGATGATGATTGTAAGTGTTTACTGACTGGCAGCTTTTATTTCAG
TATTAGCACAGCGTCTTGCCAGTGTTGGAGGCCATGTATTATTTCAGTTCAACTGGATGAAATGTTAAATAAACTCAGAATGAAAATAAA

>94721_94721_1_TSPAN17-SFXN1_TSPAN17_chr5_176083957_ENST00000310032_SFXN1_chr5_174938454_ENST00000321442_length(amino acids)=467AA_BP=290
MGLAPGSGFRAGGWPLTMPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGGLDPVWLFVVVGGV
MSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPND
WNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLVRGELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQI
FGICLAQNLVSDIKAVKANCELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRL
GESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAK

--------------------------------------------------------------
>94721_94721_2_TSPAN17-SFXN1_TSPAN17_chr5_176083957_ENST00000503045_SFXN1_chr5_174938454_ENST00000321442_length(transcript)=4347nt_BP=804nt
GGCGCTGGGCCTGGCTCCCGGCTCCGGTTTCCGGGCCGGCGGGTGGCCGCTCACCATGCCCGGCAAGCACCAGCATTTCCAGGAACCTGA
GGTCGGCTGCTGCGGGAAATACTTCCTGTTTGGCTTCAACATTGTCTTCTGGGTGCTGGGAGCCCTGTTCCTGGCTATCGGCCTCTGGGC
CTGGGGTGAGAAGGGCGTTCTCTCGAACATCTCAGCGCTGACAGATCTGGGAGGCCTTGACCCCGTGTGGCTGTTTGTGGTAGTTGGAGG
CGTCATGTCGGTGCTGGGCTTTGCTGGCTGCATTGGGGCCCTCCGGGAGAACACCTTCCTGCTCAAGTTTGACTGGATTCGAGACCAGCT
CAACCTCTTCATCAACAACAACGTCAAGGCCTACCGGGACGACATTGACCTCCAGAACCTCATTGACTTTGCTCAGGAATACTGGTCTTG
CTGCGGAGCCCGAGGCCCCAATGACTGGAACCTCAATATCTACTTCAACTGCACTGACTTGAACCCCAGCCGGGAGCGCTGCGGGGTGCC
CTTCTCCTGCTGCGTCAGGGACCCTGCGGAGGATGTCCTCAACACCCAGTGTGGCTACGACGTCCGGCTCAAACTGGTGAGAGGGGAGCT
GGAGCAGCAGGGCTTCATCCACACCAAAGGCTGCGTGGGCCAGTTTGAGAAGTGGCTGCAGGACAACCTGATTGTGGTGGCGGGAGTCTT
CATGGGCATCGCCCTCCTCCAGATCTTTGGCATCTGCCTGGCCCAGAACCTCGTGAGTGACATCAAGGCAGTGAAAGCCAACTGTGAGTT
GGGAACAGCTTACGTTTCTGCAACAACTGGTGCCGTAGCAACAGCTCTAGGACTCAATGCATTGACCAAGCATGTCTCACCACTGATAGG
ACGTTTTGTTCCCTTTGCTGCCGTAGCTGCTGCTAATTGCATTAATATTCCATTAATGAGGCAAAGGGAACTCAAAGTTGGCATTCCCGT
CACGGATGAGAATGGGAACCGCTTGGGGGAGTCGGCGAACGCTGCGAAACAAGCCATCACGCAAGTTGTCGTGTCCAGGATTCTCATGGC
AGCCCCTGGCATGGCCATCCCTCCATTCATTATGAACACTTTGGAAAAGAAAGCCTTTTTGAAGAGGTTCCCATGGATGAGTGCACCCAT
TCAAGTTGGGTTAGTTGGCTTCTGTTTGGTGTTTGCTACACCCCTGTGTTGTGCCCTGTTTCCTCAGAAAAGTTCCATGTCTGTGACAAG
CTTGGAGGCCGAGTTGCAAGCTAAGATCCAAGAGAGCCATCCTGAATTGCGACGCGTGTACTTCAATAAGGGATTGTAAAGCAGGGAGGA
AACCTCTGCAGCTCATTCTGCCACTGCAAAGCTGGTGTAGCCATGCTGGTGAGAAAAATCCTGTTCAACCTGGGTTCTCCCAGTTACGGA
AACCTTTTAAAGATCCACATTAGCCTTTTAGAATAAAGCTGCTACTTTAACAGAGCACCTGGCGTGGGCCAAGTGCCTGATACTCCCTTA
CACTGAATCATGTTATGATTTATAGAAATACCTTTCCTGTAGCTTTTATAGTCATTGTTTTTCAAAGACGATATACCAGCCCTCACCCAG
GTTTTAAAAAAGCACTGGTAGGCATAGAATAGGTGCTCAGTATATGGTCAGTAAATGTTCTATTGATTATCAATCAGTGAAAAAAGAAAT
CTGTTTAAAATACTGAATTTTCATCTCACTCCCATTGCAAATCAAGGAGATCTCAGCAGTGAACTGGGAAAATACAAAAGCTCTGGGCTA
ATCTATAAAAACTTACCCTGAAATATTAAGGGCAGTTTGCTTCTAGTTTGGGGATTGCGCTAGCCCAATGAAGGTGATGAAGCTTTTGGA
TTTGGAGGGTAAAAGCTCCTTCACACCCCTTCCAAAAGTCAGTCACAGACCACTGCAACATGCCTTCCCTGCTGGATCATTATATACATT
CAGATTGTGAGTGGATTGCCTTGGTTGACTTTTAATTTATTGTTTTTTGTTCTTATAAAGATGATAATCTTACCTTGCAGTTATTGACTT
TATATTCAATTATTTACATCAAATAATGAAATAACTGAAATGTACAAATGTCAAATTTTGGAAGTATATTCAATACCAATGCTGTATGAG
TGGGCTGAATCCAGTTCATTGTTTTTTTTTTGGTAAGAAGTGAGACTACAGTTCCAGCTACCTACATGTCTTTTCTTGTCATCCTTATAG
ATCTCTTTGGCTTTCAGAAAGATACAGTGATAATGTGTGTATGAATCAGTCACAATGAATTTTACTTGAATATTGTATGTTGCATTCCAC
TTCATTTGAAAATAATGAAACCATGTACCACTGTTTACATCATCTGTAGTGATTTCATAGATAATATATTTAATATGACAGATTATGTTT
CAACTCTGTAGATGTTTAACGTCATAGACAGTTGGCCCTCTGTATCCGTGAGCTCTATATCTGTGAATTCAACCAAGTTTGGATGGAAAA
TTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTAGTCTCGGCTCACTGCAAGCTCC
GCCTCCCGGGTTCACGCCGTTCTCCTGCCTCAGCCTCTCTGAGAAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTTG
TATTTTTAGTAGAGACGGGGTTTCACTGTGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTTGGCCTCCCAAGGTGCTGGGATTACA
AGCGTGAGCCACCGCACCCGGCCTGAAAATATTTTCTAAAAAGATAAAAAATATACATAACGATGAAAAATAATACAAATTTAAAAACCA
ATACAGTATAACAACTATTTACATAGTGCTTACATTGTATTAGGTGTTATAAGCAATCTAGAGATGATTTAGCAAGTATACAGGAGGATG
TGCCTAGGTTATATGCAAATACTGTGCCATTTTATATCAGGAACTTGAGCATCTGCAGATATTGGTATCGGAGGGCGGTCCTGGAACCAA
GCATCCACGGATACTGAGGGGTGACATTTCATGAAGTGTAGATCATTGTATTCAGAGATTGTAAATGAAAAAAATATAGAAACTATTTAG
TTTTGGTAGATTTTTTTTCTGACAATGTGACCAGACTGAATTTCCTCATAAAGAAAAAATGGCGTGCCTTGTGTCTGTGTTTCTCTTTTC
TCTGAAAGGATTAATAGATCTGAAGCTTTGGGCCACTCAGAGCCTTCCTTGATGCTGCCAGAGTCTTCTTATTTAGATTTTCTGTCTTAA
ACCATTGGAAGCAAAACGGTTTTCCCATGACATTCTGGCCTTGGACAGATTCTGTTGTCCTCGACGCGTCTCTTTATAAAGTGGTAAAAG
CCTGAAATTCAGGGCAGCTCTCCATGAGGTGCTGAAGGGCTCTTTTCATAAGAAGCTAAGGCACTGCTGCCTGCCCCAGGTGTCCCGCTC
CTCTCAGAGTCCTCCCCCTACCAGGTAGTGTGTAGCTCCATTTCAGAATGTTAACCTCCAGTGAAGAGCTAATGACTGGTTAGAAGATTG
ACAAACTAACCAAAATTTTACACACTCCGGTTATGTGTGTGAAAGGTTATAAAAGGAATGGCCGGGTGCGGTGGCTCACCCCTGTAATCC
CAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGAGAAACCCCGCCTCTACTA
AAAATACAAAAAATTAGCCAGGCATGGAGGCACATGCCTATAATCCCAGCTACTCGGGAGGCTGAGGTAGGAGAATCGCTTGAATCCGGG
AGCTGGAGGTTGCAGTGAGCCAAGATCGCACCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAGAG
ATTATAAAAGGGATGATGAACATGGAGCTGCATCTTTTTAAACGTTGTTTTTTGATGCTTCAGACTCTTAATGCTTTTATATAAAGCTAT
CAACTGTATGTTGATCACAGTTTATAAGAAAGAACAAATCAAGATTGGCAATCCTTGCCGATCTTTTAGAAATACCTTTTCTGGAGAAAA
AAAAATCCACATGAAGTGCAATAAGCTTATAAAGCTAAGTAGTTATTAATATTTCTATTAACATGATACAAAGGATGATGATTGTAAGTG
TTTACTGACTGGCAGCTTTTATTTCAGTATTAGCACAGCGTCTTGCCAGTGTTGGAGGCCATGTATTATTTCAGTTCAACTGGATGAAAT

>94721_94721_2_TSPAN17-SFXN1_TSPAN17_chr5_176083957_ENST00000503045_SFXN1_chr5_174938454_ENST00000321442_length(amino acids)=444AA_BP=267
MGLAPGSGFRAGGWPLTMPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGGLDPVWLFVVVGGV
MSVLGFAGCIGALRENTFLLKFDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPF
SCCVRDPAEDVLNTQCGYDVRLKLVRGELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKAVKANCELG
TAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAA

--------------------------------------------------------------
>94721_94721_3_TSPAN17-SFXN1_TSPAN17_chr5_176083957_ENST00000508164_SFXN1_chr5_174938454_ENST00000321442_length(transcript)=4466nt_BP=923nt
CATGAAGCCGCAGCCGCCCGGCTAGGCCCCGGGCGGCTCTAGCCCAGGGCGGCCCGCGGGGCGCTGGGCCTGGCTCCCGGCTCCGGTTTC
CGGGCCGGCGGGTGGCCGCTCACCATGCCCGGCAAGCACCAGCATTTCCAGGAACCTGAGGTCGGCTGCTGCGGGAAATACTTCCTGTTT
GGCTTCAACATTGTCTTCTGGGTGCTGGGAGCCCTGTTCCTGGCTATCGGCCTCTGGGCCTGGGGTGAGAAGGGCGTTCTCTCGAACATC
TCAGCGCTGACAGATCTGGGAGGCCTTGACCCCGTGTGGCTGTTTGTGGTAGTTGGAGGCGTCATGTCGGTGCTGGGCTTTGCTGGCTGC
ATTGGGGCCCTCCGGGAGAACACCTTCCTGCTCAAGTTTTTCTCCGTGTTCCTCGGTCTCATCTTCTTCCTGGAGCTGGCAACAGGGATC
CTGGCCTTTGTCTTCAAGGACTGGATTCGAGACCAGCTCAACCTCTTCATCAACAACAACGTCAAGGCCTACCGGGACGACATTGACCTC
CAGAACCTCATTGACTTTGCTCAGGAATACTGGTCTTGCTGCGGAGCCCGAGGCCCCAATGACTGGAACCTCAATATCTACTTCAACTGC
ACTGACTTGAACCCCAGCCGGGAGCGCTGCGGGGTGCCCTTCTCCTGCTGCGTCAGGGACCCTGCGGAGGATGTCCTCAACACCCAGTGT
GGCTACGACGTCCGGCTCAAACTGGAGCTGGAGCAGCAGGGCTTCATCCACACCAAAGGCTGCGTGGGCCAGTTTGAGAAGTGGCTGCAG
GACAACCTGATTGTGGTGGCGGGAGTCTTCATGGGCATCGCCCTCCTCCAGATCTTTGGCATCTGCCTGGCCCAGAACCTCGTGAGTGAC
ATCAAGGCAGTGAAAGCCAACTGTGAGTTGGGAACAGCTTACGTTTCTGCAACAACTGGTGCCGTAGCAACAGCTCTAGGACTCAATGCA
TTGACCAAGCATGTCTCACCACTGATAGGACGTTTTGTTCCCTTTGCTGCCGTAGCTGCTGCTAATTGCATTAATATTCCATTAATGAGG
CAAAGGGAACTCAAAGTTGGCATTCCCGTCACGGATGAGAATGGGAACCGCTTGGGGGAGTCGGCGAACGCTGCGAAACAAGCCATCACG
CAAGTTGTCGTGTCCAGGATTCTCATGGCAGCCCCTGGCATGGCCATCCCTCCATTCATTATGAACACTTTGGAAAAGAAAGCCTTTTTG
AAGAGGTTCCCATGGATGAGTGCACCCATTCAAGTTGGGTTAGTTGGCTTCTGTTTGGTGTTTGCTACACCCCTGTGTTGTGCCCTGTTT
CCTCAGAAAAGTTCCATGTCTGTGACAAGCTTGGAGGCCGAGTTGCAAGCTAAGATCCAAGAGAGCCATCCTGAATTGCGACGCGTGTAC
TTCAATAAGGGATTGTAAAGCAGGGAGGAAACCTCTGCAGCTCATTCTGCCACTGCAAAGCTGGTGTAGCCATGCTGGTGAGAAAAATCC
TGTTCAACCTGGGTTCTCCCAGTTACGGAAACCTTTTAAAGATCCACATTAGCCTTTTAGAATAAAGCTGCTACTTTAACAGAGCACCTG
GCGTGGGCCAAGTGCCTGATACTCCCTTACACTGAATCATGTTATGATTTATAGAAATACCTTTCCTGTAGCTTTTATAGTCATTGTTTT
TCAAAGACGATATACCAGCCCTCACCCAGGTTTTAAAAAAGCACTGGTAGGCATAGAATAGGTGCTCAGTATATGGTCAGTAAATGTTCT
ATTGATTATCAATCAGTGAAAAAAGAAATCTGTTTAAAATACTGAATTTTCATCTCACTCCCATTGCAAATCAAGGAGATCTCAGCAGTG
AACTGGGAAAATACAAAAGCTCTGGGCTAATCTATAAAAACTTACCCTGAAATATTAAGGGCAGTTTGCTTCTAGTTTGGGGATTGCGCT
AGCCCAATGAAGGTGATGAAGCTTTTGGATTTGGAGGGTAAAAGCTCCTTCACACCCCTTCCAAAAGTCAGTCACAGACCACTGCAACAT
GCCTTCCCTGCTGGATCATTATATACATTCAGATTGTGAGTGGATTGCCTTGGTTGACTTTTAATTTATTGTTTTTTGTTCTTATAAAGA
TGATAATCTTACCTTGCAGTTATTGACTTTATATTCAATTATTTACATCAAATAATGAAATAACTGAAATGTACAAATGTCAAATTTTGG
AAGTATATTCAATACCAATGCTGTATGAGTGGGCTGAATCCAGTTCATTGTTTTTTTTTTGGTAAGAAGTGAGACTACAGTTCCAGCTAC
CTACATGTCTTTTCTTGTCATCCTTATAGATCTCTTTGGCTTTCAGAAAGATACAGTGATAATGTGTGTATGAATCAGTCACAATGAATT
TTACTTGAATATTGTATGTTGCATTCCACTTCATTTGAAAATAATGAAACCATGTACCACTGTTTACATCATCTGTAGTGATTTCATAGA
TAATATATTTAATATGACAGATTATGTTTCAACTCTGTAGATGTTTAACGTCATAGACAGTTGGCCCTCTGTATCCGTGAGCTCTATATC
TGTGAATTCAACCAAGTTTGGATGGAAAATTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAG
TGGCGTAGTCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCGTTCTCCTGCCTCAGCCTCTCTGAGAAGCTGGGACTACAGGCG
CCCGCCACCACGCCCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGGTCTCGATCTCCTGACCTCGTGATCCGCCCG
CCTTGGCCTCCCAAGGTGCTGGGATTACAAGCGTGAGCCACCGCACCCGGCCTGAAAATATTTTCTAAAAAGATAAAAAATATACATAAC
GATGAAAAATAATACAAATTTAAAAACCAATACAGTATAACAACTATTTACATAGTGCTTACATTGTATTAGGTGTTATAAGCAATCTAG
AGATGATTTAGCAAGTATACAGGAGGATGTGCCTAGGTTATATGCAAATACTGTGCCATTTTATATCAGGAACTTGAGCATCTGCAGATA
TTGGTATCGGAGGGCGGTCCTGGAACCAAGCATCCACGGATACTGAGGGGTGACATTTCATGAAGTGTAGATCATTGTATTCAGAGATTG
TAAATGAAAAAAATATAGAAACTATTTAGTTTTGGTAGATTTTTTTTCTGACAATGTGACCAGACTGAATTTCCTCATAAAGAAAAAATG
GCGTGCCTTGTGTCTGTGTTTCTCTTTTCTCTGAAAGGATTAATAGATCTGAAGCTTTGGGCCACTCAGAGCCTTCCTTGATGCTGCCAG
AGTCTTCTTATTTAGATTTTCTGTCTTAAACCATTGGAAGCAAAACGGTTTTCCCATGACATTCTGGCCTTGGACAGATTCTGTTGTCCT
CGACGCGTCTCTTTATAAAGTGGTAAAAGCCTGAAATTCAGGGCAGCTCTCCATGAGGTGCTGAAGGGCTCTTTTCATAAGAAGCTAAGG
CACTGCTGCCTGCCCCAGGTGTCCCGCTCCTCTCAGAGTCCTCCCCCTACCAGGTAGTGTGTAGCTCCATTTCAGAATGTTAACCTCCAG
TGAAGAGCTAATGACTGGTTAGAAGATTGACAAACTAACCAAAATTTTACACACTCCGGTTATGTGTGTGAAAGGTTATAAAAGGAATGG
CCGGGTGCGGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTG
GCCAACATGGAGAAACCCCGCCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGAGGCACATGCCTATAATCCCAGCTACTCGGGAGG
CTGAGGTAGGAGAATCGCTTGAATCCGGGAGCTGGAGGTTGCAGTGAGCCAAGATCGCACCATTGCACTCCAGCCTGGGCAACAAGAGCG
AAACTCCATCTCAAAAAAAAAAAAAAGAGATTATAAAAGGGATGATGAACATGGAGCTGCATCTTTTTAAACGTTGTTTTTTGATGCTTC
AGACTCTTAATGCTTTTATATAAAGCTATCAACTGTATGTTGATCACAGTTTATAAGAAAGAACAAATCAAGATTGGCAATCCTTGCCGA
TCTTTTAGAAATACCTTTTCTGGAGAAAAAAAAATCCACATGAAGTGCAATAAGCTTATAAAGCTAAGTAGTTATTAATATTTCTATTAA
CATGATACAAAGGATGATGATTGTAAGTGTTTACTGACTGGCAGCTTTTATTTCAGTATTAGCACAGCGTCTTGCCAGTGTTGGAGGCCA

>94721_94721_3_TSPAN17-SFXN1_TSPAN17_chr5_176083957_ENST00000508164_SFXN1_chr5_174938454_ENST00000321442_length(amino acids)=464AA_BP=287
MGLAPGSGFRAGGWPLTMPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGGLDPVWLFVVVGGV
MSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPND
WNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGI
CLAQNLVSDIKAVKANCELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGES
ANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TSPAN17-SFXN1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TSPAN17-SFXN1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TSPAN17-SFXN1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source