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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:TSPAN3-REEP1 (FusionGDB2 ID:94760)

Fusion Gene Summary for TSPAN3-REEP1

Fusion gene summary

Fusion gene information	Fusion gene name: TSPAN3-REEP1
	Fusion gene ID: 94760
		Hgene	Tgene
	Gene symbol	TSPAN3	REEP1
	Gene ID	10099	65055
	Gene name	tetraspanin 3	receptor accessory protein 1
	Synonyms	TM4-A\|TM4SF8\|TSPAN-3	C2orf23\|HMN5B\|SPG31\|Yip2a
	Cytomap	15q24.3	2p11.2
	Type of gene	protein-coding	protein-coding
	Description	tetraspanin-3tetraspan 3tetraspan TM4SFtetraspanin TM4-Atransmembrane 4 superfamily member 8	receptor expression-enhancing protein 1spastic paraplegia 31 protein
	Modification date	20200322	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000267970, ENST00000346495, ENST00000424443, ENST00000559494, ENST00000558394, ENST00000558745, ENST00000561277,	ENST00000473407, ENST00000165698, ENST00000535845, ENST00000538924, ENST00000540790, ENST00000541910,
Fusion gene scores	* DoF score	13 X 10 X 7=910	9 X 5 X 8=360
	# samples	14	9
	** MAII score	log2(14/910*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TSPAN3 [Title/Abstract] AND REEP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TSPAN3(77363234)-REEP1(86444233), # samples:1
Anticipated loss of major functional domain due to fusion event.	TSPAN3-REEP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	REEP1	GO:0051205	protein insertion into membrane	15550249

Fusion gene breakpoints across TSPAN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across REEP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-CG-5733-11A	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-

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Fusion Gene ORF analysis for TSPAN3-REEP1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000267970	ENST00000473407	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
5CDS-intron	ENST00000346495	ENST00000473407	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
5CDS-intron	ENST00000424443	ENST00000473407	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
5CDS-intron	ENST00000559494	ENST00000473407	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
5UTR-3CDS	ENST00000558394	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
5UTR-3CDS	ENST00000558394	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
5UTR-3CDS	ENST00000558394	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
5UTR-3CDS	ENST00000558394	ENST00000540790	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
5UTR-3CDS	ENST00000558394	ENST00000541910	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
5UTR-intron	ENST00000558394	ENST00000473407	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
Frame-shift	ENST00000267970	ENST00000540790	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
Frame-shift	ENST00000267970	ENST00000541910	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
Frame-shift	ENST00000346495	ENST00000540790	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
Frame-shift	ENST00000346495	ENST00000541910	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
Frame-shift	ENST00000424443	ENST00000540790	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
Frame-shift	ENST00000424443	ENST00000541910	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
Frame-shift	ENST00000559494	ENST00000540790	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
Frame-shift	ENST00000559494	ENST00000541910	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000267970	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000267970	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000267970	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000346495	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000346495	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000346495	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000424443	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000424443	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000424443	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000559494	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000559494	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
In-frame	ENST00000559494	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-3CDS	ENST00000558745	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-3CDS	ENST00000558745	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-3CDS	ENST00000558745	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-3CDS	ENST00000558745	ENST00000540790	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-3CDS	ENST00000558745	ENST00000541910	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-3CDS	ENST00000561277	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-3CDS	ENST00000561277	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-3CDS	ENST00000561277	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-3CDS	ENST00000561277	ENST00000540790	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-3CDS	ENST00000561277	ENST00000541910	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-intron	ENST00000558745	ENST00000473407	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-
intron-intron	ENST00000561277	ENST00000473407	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000267970	TSPAN3	chr15	77363234	-	ENST00000165698	REEP1	chr2	86444233	-	3455	337	25	408	127
ENST00000267970	TSPAN3	chr15	77363234	-	ENST00000535845	REEP1	chr2	86444233	-	3449	337	25	408	127
ENST00000267970	TSPAN3	chr15	77363234	-	ENST00000538924	REEP1	chr2	86444233	-	3449	337	25	408	127
ENST00000346495	TSPAN3	chr15	77363234	-	ENST00000165698	REEP1	chr2	86444233	-	3336	218	2193	1861	110
ENST00000346495	TSPAN3	chr15	77363234	-	ENST00000535845	REEP1	chr2	86444233	-	3330	218	2193	1861	110
ENST00000346495	TSPAN3	chr15	77363234	-	ENST00000538924	REEP1	chr2	86444233	-	3330	218	2193	1861	110
ENST00000424443	TSPAN3	chr15	77363234	-	ENST00000165698	REEP1	chr2	86444233	-	3336	218	2193	1861	110
ENST00000424443	TSPAN3	chr15	77363234	-	ENST00000535845	REEP1	chr2	86444233	-	3330	218	2193	1861	110
ENST00000424443	TSPAN3	chr15	77363234	-	ENST00000538924	REEP1	chr2	86444233	-	3330	218	2193	1861	110
ENST00000559494	TSPAN3	chr15	77363234	-	ENST00000165698	REEP1	chr2	86444233	-	3261	143	2118	1786	110
ENST00000559494	TSPAN3	chr15	77363234	-	ENST00000535845	REEP1	chr2	86444233	-	3255	143	2118	1786	110
ENST00000559494	TSPAN3	chr15	77363234	-	ENST00000538924	REEP1	chr2	86444233	-	3255	143	2118	1786	110

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000267970	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.49962592	0.5003741
ENST00000267970	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.35279942	0.64720064
ENST00000267970	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.35279942	0.64720064
ENST00000346495	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.5020513	0.4979487
ENST00000346495	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.3555924	0.6444076
ENST00000346495	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.3555924	0.6444076
ENST00000424443	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.5020513	0.4979487
ENST00000424443	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.3555924	0.6444076
ENST00000424443	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.3555924	0.6444076
ENST00000559494	ENST00000165698	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.51905066	0.4809493
ENST00000559494	ENST00000535845	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.36854744	0.6314526
ENST00000559494	ENST00000538924	TSPAN3	chr15	77363234	-	REEP1	chr2	86444233	-	0.36854744	0.6314526

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Fusion Genomic Features for TSPAN3-REEP1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSPAN3-REEP1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:77363234/chr2:86444233)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000267970

1_11

254.0

Topological domain

Cytoplasmic

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000346495

1_11

229.0

Topological domain

Cytoplasmic

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000424443

1_11

190.0

Topological domain

Cytoplasmic

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000535845

170_173

171

175.0

Compositional bias

Note=Poly-Pro

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000541910

170_173

120

144.0

Compositional bias

Note=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000267970

107_212

254.0

Topological domain

Extracellular

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000267970

234_253

254.0

Topological domain

Cytoplasmic

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000267970

33_50

254.0

Topological domain

Extracellular

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000267970

72_85

254.0

Topological domain

Cytoplasmic

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000346495

107_212

229.0

Topological domain

Extracellular

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000346495

234_253

229.0

Topological domain

Cytoplasmic

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000346495

33_50

229.0

Topological domain

Extracellular

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000346495

72_85

229.0

Topological domain

Cytoplasmic

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000424443

107_212

190.0

Topological domain

Extracellular

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000424443

234_253

190.0

Topological domain

Cytoplasmic

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000424443

33_50

190.0

Topological domain

Extracellular

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000424443

72_85

190.0

Topological domain

Cytoplasmic

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000267970

12_32

254.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000267970

213_233

254.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000267970

51_71

254.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000267970

86_106

254.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000346495

12_32

229.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000346495

213_233

229.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000346495

51_71

229.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000346495

86_106

229.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000424443

12_32

190.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000424443

213_233

190.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000424443

51_71

190.0

Transmembrane

Helical

Hgene

TSPAN3

chr15:77363234

chr2:86444233

ENST00000424443

86_106

190.0

Transmembrane

Helical

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000165698

170_173

198

202.0

Compositional bias

Note=Poly-Pro

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000538924

170_173

205

209.0

Compositional bias

Note=Poly-Pro

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000165698

1_21

198

202.0

Transmembrane

Helical

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000165698

35_55

198

202.0

Transmembrane

Helical

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000535845

1_21

171

175.0

Transmembrane

Helical

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000535845

35_55

171

175.0

Transmembrane

Helical

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000538924

1_21

205

209.0

Transmembrane

Helical

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000538924

35_55

205

209.0

Transmembrane

Helical

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000541910

1_21

120

144.0

Transmembrane

Helical

Tgene

REEP1

chr15:77363234

chr2:86444233

ENST00000541910

35_55

120

144.0

Transmembrane

Helical

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Fusion Gene Sequence for TSPAN3-REEP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>94760_94760_1_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000267970_REEP1_chr2_86444233_ENST00000165698_length(transcript)=3455nt_BP=337nt
CTGCAGCCTCCGCAGAGGCGATTGGCTGAAGCTACCGGCCGCGTGGGGCGGGACTCGGTTGCCAGGGAGCGGCGCGGGAGCCCTGAGGGG
ACTGCGGCGGCTGCGCGGAGGAGCGAGGCACTTGCTGGGGTCGGGGCTGCGCGACGGCGCAGGGGCTGCGGGGAGCGCCGCGCAGGCCGT
GCAGTTCCTAGCGAGGAGGCGCCGCCGCCATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGG
CGCCATGGGCCAGTGCGGCATCACCTCCTCCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATC
TCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTT
CTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCT
CTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGG
GGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAG
AATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTT
ACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGC
TGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAG
CTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACA
AGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAG
GAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTG
AGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTT
CCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAAC
TGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAG
CTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATG
TAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTC
TCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCA
CTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAG
TTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAG
TCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTT
AGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGAT
TTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGT
GCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATA
TACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTAC
ACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTT
CGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCA
GACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTC
AAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACG
TATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAG
GATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAA
CTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCC
TGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTT
GTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGT
ACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAAT
AGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACAT

>94760_94760_1_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000267970_REEP1_chr2_86444233_ENST00000165698_length(amino acids)=127AA_BP=66
MKLPAAWGGTRLPGSGAGALRGLRRLRGGARHLLGSGLRDGAGAAGSAAQAVQFLARRRRRHCRSLGERSPALRAGPSRATGAMGQCGIT

--------------------------------------------------------------
>94760_94760_2_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000267970_REEP1_chr2_86444233_ENST00000535845_length(transcript)=3449nt_BP=337nt
CTGCAGCCTCCGCAGAGGCGATTGGCTGAAGCTACCGGCCGCGTGGGGCGGGACTCGGTTGCCAGGGAGCGGCGCGGGAGCCCTGAGGGG
ACTGCGGCGGCTGCGCGGAGGAGCGAGGCACTTGCTGGGGTCGGGGCTGCGCGACGGCGCAGGGGCTGCGGGGAGCGCCGCGCAGGCCGT
GCAGTTCCTAGCGAGGAGGCGCCGCCGCCATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGG
CGCCATGGGCCAGTGCGGCATCACCTCCTCCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATC
TCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTT
CTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCT
CTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGG
GGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAG
AATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTT
ACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGC
TGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAG
CTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACA
AGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAG
GAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTG
AGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTT
CCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAAC
TGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAG
CTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATG
TAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTC
TCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCA
CTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAG
TTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAG
TCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTT
AGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGAT
TTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGT
GCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATA
TACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTAC
ACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTT
CGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCA
GACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTC
AAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACG
TATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAG
GATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAA
CTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCC
TGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTT
GTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGT
ACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAAT
AGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACAT

>94760_94760_2_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000267970_REEP1_chr2_86444233_ENST00000535845_length(amino acids)=127AA_BP=66
MKLPAAWGGTRLPGSGAGALRGLRRLRGGARHLLGSGLRDGAGAAGSAAQAVQFLARRRRRHCRSLGERSPALRAGPSRATGAMGQCGIT

--------------------------------------------------------------
>94760_94760_3_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000267970_REEP1_chr2_86444233_ENST00000538924_length(transcript)=3449nt_BP=337nt
CTGCAGCCTCCGCAGAGGCGATTGGCTGAAGCTACCGGCCGCGTGGGGCGGGACTCGGTTGCCAGGGAGCGGCGCGGGAGCCCTGAGGGG
ACTGCGGCGGCTGCGCGGAGGAGCGAGGCACTTGCTGGGGTCGGGGCTGCGCGACGGCGCAGGGGCTGCGGGGAGCGCCGCGCAGGCCGT
GCAGTTCCTAGCGAGGAGGCGCCGCCGCCATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGG
CGCCATGGGCCAGTGCGGCATCACCTCCTCCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATC
TCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTT
CTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCT
CTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGG
GGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAG
AATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTT
ACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGC
TGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAG
CTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACA
AGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAG
GAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTG
AGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTT
CCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAAC
TGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAG
CTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATG
TAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTC
TCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCA
CTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAG
TTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAG
TCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTT
AGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGAT
TTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGT
GCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATA
TACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTAC
ACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTT
CGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCA
GACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTC
AAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACG
TATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAG
GATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAA
CTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCC
TGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTT
GTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGT
ACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAAT
AGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACAT

>94760_94760_3_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000267970_REEP1_chr2_86444233_ENST00000538924_length(amino acids)=127AA_BP=66
MKLPAAWGGTRLPGSGAGALRGLRRLRGGARHLLGSGLRDGAGAAGSAAQAVQFLARRRRRHCRSLGERSPALRAGPSRATGAMGQCGIT

--------------------------------------------------------------
>94760_94760_4_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000346495_REEP1_chr2_86444233_ENST00000165698_length(transcript)=3336nt_BP=218nt
ACTTGCTGGGGTCGGGGCTGCGCGACGGCGCAGGGGCTGCGGGGAGCGCCGCGCAGGCCGTGCAGTTCCTAGCGAGGAGGCGCCGCCGCC
ATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGGCGCCATGGGCCAGTGCGGCATCACCTCCT
CCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCT
CGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAA
CATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATT
TTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTG
GTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACAT
TTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATAC
TTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACT
GCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCC
CTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCA
CAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGAT
TAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAG
GAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCAC
CTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCAT
AACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTG
GTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCAC
TACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGA
ATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAA
TATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTT
CGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACT
GTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAG
CTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAA
TATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGT
TAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGT
TGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTG
CCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAA
GTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAA
GATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTC
TTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGA
ACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGA
CTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGT
TCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTT
GCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCT
AGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTT
GACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATG
TAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACATCTTGAATAAAGTCTTAACATTTTTCTTTT

>94760_94760_4_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000346495_REEP1_chr2_86444233_ENST00000165698_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ

--------------------------------------------------------------
>94760_94760_5_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000346495_REEP1_chr2_86444233_ENST00000535845_length(transcript)=3330nt_BP=218nt
ACTTGCTGGGGTCGGGGCTGCGCGACGGCGCAGGGGCTGCGGGGAGCGCCGCGCAGGCCGTGCAGTTCCTAGCGAGGAGGCGCCGCCGCC
ATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGGCGCCATGGGCCAGTGCGGCATCACCTCCT
CCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCT
CGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAA
CATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATT
TTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTG
GTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACAT
TTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATAC
TTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACT
GCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCC
CTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCA
CAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGAT
TAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAG
GAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCAC
CTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCAT
AACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTG
GTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCAC
TACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGA
ATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAA
TATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTT
CGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACT
GTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAG
CTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAA
TATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGT
TAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGT
TGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTG
CCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAA
GTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAA
GATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTC
TTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGA
ACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGA
CTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGT
TCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTT
GCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCT
AGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTT
GACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATG
TAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACATCTTGAATAAAGTCTTAACATTTTTCTTTT

>94760_94760_5_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000346495_REEP1_chr2_86444233_ENST00000535845_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ

--------------------------------------------------------------
>94760_94760_6_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000346495_REEP1_chr2_86444233_ENST00000538924_length(transcript)=3330nt_BP=218nt
ACTTGCTGGGGTCGGGGCTGCGCGACGGCGCAGGGGCTGCGGGGAGCGCCGCGCAGGCCGTGCAGTTCCTAGCGAGGAGGCGCCGCCGCC
ATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGGCGCCATGGGCCAGTGCGGCATCACCTCCT
CCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCT
CGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAA
CATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATT
TTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTG
GTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACAT
TTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATAC
TTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACT
GCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCC
CTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCA
CAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGAT
TAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAG
GAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCAC
CTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCAT
AACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTG
GTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCAC
TACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGA
ATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAA
TATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTT
CGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACT
GTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAG
CTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAA
TATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGT
TAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGT
TGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTG
CCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAA
GTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAA
GATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTC
TTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGA
ACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGA
CTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGT
TCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTT
GCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCT
AGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTT
GACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATG
TAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACATCTTGAATAAAGTCTTAACATTTTTCTTTT

>94760_94760_6_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000346495_REEP1_chr2_86444233_ENST00000538924_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ

--------------------------------------------------------------
>94760_94760_7_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000424443_REEP1_chr2_86444233_ENST00000165698_length(transcript)=3336nt_BP=218nt
ACTTGCTGGGGTCGGGGCTGCGCGACGGCGCAGGGGCTGCGGGGAGCGCCGCGCAGGCCGTGCAGTTCCTAGCGAGGAGGCGCCGCCGCC
ATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGGCGCCATGGGCCAGTGCGGCATCACCTCCT
CCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCT
CGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAA
CATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATT
TTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTG
GTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACAT
TTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATAC
TTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACT
GCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCC
CTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCA
CAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGAT
TAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAG
GAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCAC
CTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCAT
AACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTG
GTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCAC
TACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGA
ATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAA
TATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTT
CGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACT
GTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAG
CTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAA
TATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGT
TAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGT
TGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTG
CCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAA
GTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAA
GATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTC
TTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGA
ACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGA
CTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGT
TCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTT
GCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCT
AGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTT
GACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATG
TAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACATCTTGAATAAAGTCTTAACATTTTTCTTTT

>94760_94760_7_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000424443_REEP1_chr2_86444233_ENST00000165698_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ

--------------------------------------------------------------
>94760_94760_8_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000424443_REEP1_chr2_86444233_ENST00000535845_length(transcript)=3330nt_BP=218nt
ACTTGCTGGGGTCGGGGCTGCGCGACGGCGCAGGGGCTGCGGGGAGCGCCGCGCAGGCCGTGCAGTTCCTAGCGAGGAGGCGCCGCCGCC
ATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGGCGCCATGGGCCAGTGCGGCATCACCTCCT
CCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCT
CGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAA
CATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATT
TTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTG
GTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACAT
TTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATAC
TTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACT
GCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCC
CTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCA
CAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGAT
TAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAG
GAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCAC
CTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCAT
AACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTG
GTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCAC
TACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGA
ATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAA
TATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTT
CGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACT
GTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAG
CTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAA
TATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGT
TAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGT
TGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTG
CCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAA
GTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAA
GATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTC
TTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGA
ACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGA
CTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGT
TCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTT
GCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCT
AGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTT
GACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATG
TAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACATCTTGAATAAAGTCTTAACATTTTTCTTTT

>94760_94760_8_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000424443_REEP1_chr2_86444233_ENST00000535845_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ

--------------------------------------------------------------
>94760_94760_9_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000424443_REEP1_chr2_86444233_ENST00000538924_length(transcript)=3330nt_BP=218nt
ACTTGCTGGGGTCGGGGCTGCGCGACGGCGCAGGGGCTGCGGGGAGCGCCGCGCAGGCCGTGCAGTTCCTAGCGAGGAGGCGCCGCCGCC
ATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGGCGCCATGGGCCAGTGCGGCATCACCTCCT
CCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCT
CGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAA
CATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATT
TTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTG
GTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACAT
TTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATAC
TTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACT
GCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCC
CTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCA
CAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGAT
TAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAG
GAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCAC
CTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCAT
AACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTG
GTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCAC
TACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGA
ATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAA
TATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTT
CGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACT
GTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAG
CTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAA
TATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGT
TAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGT
TGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTG
CCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAA
GTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAA
GATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTC
TTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGA
ACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGA
CTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGT
TCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTT
GCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCT
AGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTT
GACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATG
TAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACATCTTGAATAAAGTCTTAACATTTTTCTTTT

>94760_94760_9_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000424443_REEP1_chr2_86444233_ENST00000538924_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ

--------------------------------------------------------------
>94760_94760_10_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000559494_REEP1_chr2_86444233_ENST00000165698_length(transcript)=3261nt_BP=143nt
GGAGGCGCCGCCGCCATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGGCGCCATGGGCCAGT
GCGGCATCACCTCCTCCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGA
AAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGA
GCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCAC
TTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTA
AGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGC
TGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGT
TCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTG
ATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAAC
TCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAG
AGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCT
CCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATG
TAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGC
TTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTG
TTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCAT
GGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTC
ATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTT
CCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCC
GAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATT
TGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAG
GCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAA
GGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAA
AAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACC
AATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATG
TATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCA
ATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAAT
GGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTA
TTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGG
GAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTG
TACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATG
TTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTG
CCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAA
TAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCA
TCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCT
GATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTG
TGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACATCTTGAATAAAGTCT

>94760_94760_10_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000559494_REEP1_chr2_86444233_ENST00000165698_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ

--------------------------------------------------------------
>94760_94760_11_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000559494_REEP1_chr2_86444233_ENST00000535845_length(transcript)=3255nt_BP=143nt
GGAGGCGCCGCCGCCATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGGCGCCATGGGCCAGT
GCGGCATCACCTCCTCCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGA
AAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGA
GCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCAC
TTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTA
AGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGC
TGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGT
TCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTG
ATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAAC
TCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAG
AGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCT
CCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATG
TAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGC
TTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTG
TTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCAT
GGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTC
ATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTT
CCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCC
GAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATT
TGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAG
GCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAA
GGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAA
AAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACC
AATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATG
TATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCA
ATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAAT
GGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTA
TTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGG
GAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTG
TACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATG
TTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTG
CCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAA
TAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCA
TCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCT
GATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTG
TGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACATCTTGAATAAAGTCT

>94760_94760_11_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000559494_REEP1_chr2_86444233_ENST00000535845_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ

--------------------------------------------------------------
>94760_94760_12_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000559494_REEP1_chr2_86444233_ENST00000538924_length(transcript)=3255nt_BP=143nt
GGAGGCGCCGCCGCCATTGCCGCTCTCTCGGTGAGCGCAGCCCCGCTCTCCGGGCCGGGCCTTCGCGGGCCACCGGCGCCATGGGCCAGT
GCGGCATCACCTCCTCCAAGACCGTGCTGGTCTTTCTCAACCTCATCTTCTGGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGA
AAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGA
GCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCAC
TTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTA
AGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGC
TGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGT
TCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTG
ATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAAC
TCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAG
AGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCT
CCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATG
TAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGC
TTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTG
TTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCAT
GGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTC
ATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTT
CCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCC
GAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATT
TGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAG
GCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAA
GGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAA
AAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACC
AATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATG
TATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCA
ATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAAT
GGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTA
TTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGG
GAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTG
TACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATG
TTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTG
CCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAA
TAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCA
TCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCT
GATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTG
TGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACATCTTGAATAAAGTCT

>94760_94760_12_TSPAN3-REEP1_TSPAN3_chr15_77363234_ENST00000559494_REEP1_chr2_86444233_ENST00000538924_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TSPAN3-REEP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TSPAN3-REEP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TSPAN3-REEP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source