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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TSPAN7-CIAPIN1 (FusionGDB2 ID:94781)

Fusion Gene Summary for TSPAN7-CIAPIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN7-CIAPIN1
Fusion gene ID: 94781
HgeneTgene
Gene symbol

TSPAN7

CIAPIN1

Gene ID

7102

57019

Gene nametetraspanin 7cytokine induced apoptosis inhibitor 1
SynonymsA15|CCG-B7|CD231|DXS1692E|MRX58|MXS1|TALLA-1|TM4SF2|TM4SF2bAnamorsin|CIAE2|DRE2|PRO0915
Cytomap

Xp11.4

16q21

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-7CD231 antigenT-cell acute lymphoblastic leukemia associated antigen 1cell surface glycoprotein A15membrane component chromosome X surface marker 1membrane component, X chromosome, surface marker 1tetraspanin proteintransmembrane 4 supeanamorsinfe-S cluster assembly protein DRE2 homologpredicted protein of HQ0915
Modification date2020032020200327
UniProtAcc.

Q6FI81

Ensembl transtripts involved in fusion geneENST00000286824, ENST00000378482, 
ENST00000422612, ENST00000488893, 
ENST00000545599, 		ENST00000394391, 
ENST00000565961, ENST00000567518, 
ENST00000568940, ENST00000569246, 
ENST00000569370, ENST00000569979, 
Fusion gene scores* DoF score4 X 5 X 1=205 X 5 X 2=50
# samples 55
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/50*10)=0
Context

PubMed: TSPAN7 [Title/Abstract] AND CIAPIN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSPAN7(38427586)-CIAPIN1(57462464), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TSPAN7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CIAPIN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABM970177TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+


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Fusion Gene ORF analysis for TSPAN7-CIAPIN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000286824ENST00000394391TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000286824ENST00000565961TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000286824ENST00000567518TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000378482ENST00000394391TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000378482ENST00000565961TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000378482ENST00000567518TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000422612ENST00000394391TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000422612ENST00000565961TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000422612ENST00000567518TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000488893ENST00000394391TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000488893ENST00000565961TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000488893ENST00000567518TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000545599ENST00000394391TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000545599ENST00000565961TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-3UTRENST00000545599ENST00000567518TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000286824ENST00000568940TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000286824ENST00000569246TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000286824ENST00000569370TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000286824ENST00000569979TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000378482ENST00000568940TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000378482ENST00000569246TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000378482ENST00000569370TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000378482ENST00000569979TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000422612ENST00000568940TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000422612ENST00000569246TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000422612ENST00000569370TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000422612ENST00000569979TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000488893ENST00000568940TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000488893ENST00000569246TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000488893ENST00000569370TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000488893ENST00000569979TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000545599ENST00000568940TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000545599ENST00000569246TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000545599ENST00000569370TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+
intron-intronENST00000545599ENST00000569979TSPAN7chrX

38427586

+CIAPIN1chr16

57462464

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TSPAN7-CIAPIN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSPAN7-CIAPIN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38427586/:57462464)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CIAPIN1

Q6FI81

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TSPAN7-CIAPIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TSPAN7-CIAPIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TSPAN7-CIAPIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TSPAN7-CIAPIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource