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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TTC12-LUC7L2 (FusionGDB2 ID:94893)

Fusion Gene Summary for TTC12-LUC7L2

Fusion gene summary

Fusion gene information	Fusion gene name: TTC12-LUC7L2
	Fusion gene ID: 94893
		Hgene	Tgene
	Gene symbol	TTC12	LUC7L2
	Gene ID	54970	51631
	Gene name	tetratricopeptide repeat domain 12	LUC7 like 2, pre-mRNA splicing factor
	Synonyms	CILD45\|TPARM	CGI-59\|CGI-74\|LUC7B2
	Cytomap	11q23.2	7q34
	Type of gene	protein-coding	protein-coding
	Description	tetratricopeptide repeat protein 12TPR repeat protein 12	putative RNA-binding protein Luc7-like 2LUC7-like 2
	Modification date	20200314	20200313
	UniProtAcc	.	Q9Y383
	Ensembl transtripts involved in fusion gene	ENST00000478125, ENST00000314756, ENST00000393020, ENST00000483239, ENST00000529221,	ENST00000541515,
Fusion gene scores	* DoF score	8 X 6 X 4=192	14 X 13 X 7=1274
	# samples	9	14
	** MAII score	log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1274*10)=-3.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TTC12 [Title/Abstract] AND LUC7L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TTC12(113215162)-LUC7L2(139097297), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TTC12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LUC7L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CR-6467-01A	TTC12	chr11	113215162	-	LUC7L2	chr7	139097297	+
ChimerDB4	HNSC	TCGA-CR-6467-01A	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+
ChimerDB4	HNSC	TCGA-CR-6467	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+

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Fusion Gene ORF analysis for TTC12-LUC7L2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000478125	ENST00000541515	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+
In-frame	ENST00000314756	ENST00000541515	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+
In-frame	ENST00000393020	ENST00000541515	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+
In-frame	ENST00000483239	ENST00000541515	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+
In-frame	ENST00000529221	ENST00000541515	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000393020

TTC12

chr11

113215162

ENST00000541515

LUC7L2

chr7

139097297

2218

1559

405

1958

517

ENST00000529221

TTC12

chr11

113215162

ENST00000541515

LUC7L2

chr7

139097297

1918

1259

1658

543

ENST00000314756

TTC12

chr11

113215162

ENST00000541515

LUC7L2

chr7

139097297

1864

1205

1604

517

ENST00000483239

TTC12

chr11

113215162

ENST00000541515

LUC7L2

chr7

139097297

1848

1189

1588

523

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393020	ENST00000541515	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+	0.007393035	0.992607
ENST00000529221	ENST00000541515	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+	0.009181691	0.9908183
ENST00000314756	ENST00000541515	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+	0.010834463	0.9891655
ENST00000483239	ENST00000541515	TTC12	chr11	113215162	+	LUC7L2	chr7	139097297	+	0.008049426	0.99195063

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Fusion Genomic Features for TTC12-LUC7L2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TTC12	chr11	113215162	+	LUC7L2	chr7	139097296	+	0.001759937	0.9982401
TTC12	chr11	113215162	+	LUC7L2	chr7	139097296	+	0.001759937	0.9982401
TTC12	chr11	113215162	+	LUC7L2	chr7	139097296	+	0.001759937	0.9982401
TTC12	chr11	113215162	+	LUC7L2	chr7	139097296	+	0.001759937	0.9982401

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTC12-LUC7L2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:113215162/chr7:139097297)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LUC7L2 Q9Y383
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May bind to RNA via its Arg/Ser-rich domain.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TTC12

chr11:113215162

chr7:139097297

ENST00000314756

106_139

384

733.0

Repeat

Note=TPR 1

Hgene

TTC12

chr11:113215162

chr7:139097297

ENST00000314756

140_173

384

733.0

Repeat

Note=TPR 2

Hgene

TTC12

chr11:113215162

chr7:139097297

ENST00000314756

174_207

384

733.0

Repeat

Note=TPR 3

Hgene

TTC12

chr11:113215162

chr7:139097297

ENST00000529221

106_139

384

706.0

Repeat

Note=TPR 1

Hgene

TTC12

chr11:113215162

chr7:139097297

ENST00000529221

140_173

384

706.0

Repeat

Note=TPR 2

Hgene

TTC12

chr11:113215162

chr7:139097297

ENST00000529221

174_207

384

706.0

Repeat

Note=TPR 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TTC12-LUC7L2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>94893_94893_1_TTC12-LUC7L2_TTC12_chr11_113215162_ENST00000314756_LUC7L2_chr7_139097297_ENST00000541515_length(transcript)=1864nt_BP=1205nt
ACTGCGCCATTTCCTGTCCAAAGCTGGGCGAATCAGGGATTCCGGTTCACAATGGATGCTGATAAAGAGAAAGATTTGCAGAAATTTCTT
AAAAATGTGGATGAAATCTCCAATTTAATTCAGGAGATGAATTCTGATGACCCAGTTGTGCAACAGAAAGCTGTCCTGGAGACAGAAAAG
AGACTACTGCTTATGGAGGAAGACCAGGAGGAGGATGAATGCAGGACCACCTTGAACAAGACTATGATCAGTCCTCCACAAACTGCTATG
AAGAGTGCAGAAGAAATAAACTCAGAGGCCTTCTTGGCATCTGTGGAGAAGGATGCAAAGGAACGAGCCAAGAGAAGAAGGGAAAACAAA
GTCTTGGCGGATGCCCTAAAAGAAAAAGGGAATGAAGCATTTGCTGAAGGCAATTATGAAACAGCTATCCTGCGCTACAGTGAGGGTTTG
GAGAAGCTGAAGGACATGAAAGTGCTGTACACCAACCGAGCCCAGGCTTATATGAAACTTGAGGACTATGAGAAGGCACTGGTGGATTGT
GAGTGGGCTCTCAAGTGTGATGAAAAATGCACAAAAGCATATTTTCACATGGGAAAAGCCAACCTGGCCCTGAAGAACTACAGTGTGTCT
AGAGAGTGTTATAAGAAGATCTTAGAAATAAACCCCAAGCTGCAAACCCAGGTGAAAGGTTACCTGAATCAAGTAGATCTTCAGGAAAAA
GCAGACCTTCAAGAAAAGGAAGCCCACGAACTGCTGGATTCAGGAAAGAACACAGCCGTGACCACCAAGAACCTCCTGGAGACCCTTTCC
AAGCCTGACCAGATCCCCTTGTTCTATGCTGGGGGGATTGAGATCCTGACTGAAATGATAAATGAGTGCACAGAACAAACTTTATTCAGA
ATGCACAATGGATTTAGTATCATCAGTGACAACGAGGTCATAAGAAGGTGTTTTTCCACAGCAGGAAATGATGCAGTTGAAGAAATGGTC
TGTGTGTCTGTTCTCAAGCTCTGGCAAGCAGTGTGCAGCAGGAACGAGGAAAACCAGCGTGTGCTAGTGATACACCATGACAGGGCCAGG
CTGTTGGCCGCCCTCTTGTCCTCCAAGGTCCTGGCCATCCGGCAGCAGAGCTTTGCCCTGCTGCTGCATCTCGCCCAGACTGAGAGCGGA
CGGAGCCTGATCATCAACCACCTTGACCTGACCAGGTCCCGATCACACAGCAAGAATCCAAAAAGATCCAGGTCCAGAGAGCATCGCAGA
CATCGATCTCGCTCCATGTCACGTGAACGCAAGAGGAGAACTCGATCCAAATCTCGGGAGAAACGCCATCGCCACAGGTCCCGCTCCAGC
AGCCGTAGCCGCAGCCGTAGCCACCAGAGAAGTCGGCACAGTTCTAGAGATAGGAGCAGAGAACGATCCAAGAGGAGATCCTCAAAAGAA
AGATTCAGAGACCAAGACTTAGCATCATGTGACAGAGACAGGAGTTCAAGAGACAGATCACCTCGTGACAGAGATCGGAAAGATAAGAAG
CGGTCCTATGAGAGTGCTAATGGCAGATCAGAAGACAGGAGGAGCTCTGAAGAGCGCGAAGCAGGGGAGATCTAACTAGCTGTGTACATT
TCTTCAGTCCTTAAGCTTCCTACGGAGTTACGTACTATTGTTTAGTTCACAGCTGTTCAGGGTGACAGTGAGCAGATCCAGACACCAGAT
CCAGCTAGGCTAGATGTACAGTATCTAACTTGATCTGAACTGAACCTGTTTTCCTTGATGATGCCTAAAACTACATCCATAGTTTCTGGT

>94893_94893_1_TTC12-LUC7L2_TTC12_chr11_113215162_ENST00000314756_LUC7L2_chr7_139097297_ENST00000541515_length(amino acids)=517AA_BP=384
MDADKEKDLQKFLKNVDEISNLIQEMNSDDPVVQQKAVLETEKRLLLMEEDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEK
DAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHM
GKANLALKNYSVSRECYKKILEINPKLQTQVKGYLNQVDLQEKADLQEKEAHELLDSGKNTAVTTKNLLETLSKPDQIPLFYAGGIEILT
EMINECTEQTLFRMHNGFSIISDNEVIRRCFSTAGNDAVEEMVCVSVLKLWQAVCSRNEENQRVLVIHHDRARLLAALLSSKVLAIRQQS
FALLLHLAQTESGRSLIINHLDLTRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRSRHSSRD

--------------------------------------------------------------
>94893_94893_2_TTC12-LUC7L2_TTC12_chr11_113215162_ENST00000393020_LUC7L2_chr7_139097297_ENST00000541515_length(transcript)=2218nt_BP=1559nt
AGTGCGTGCGGCCTGGCCTCTTTGCGCCCGGCGGGCAGCGCGCGTCTGGGGCAGGCTCCGCGCGGGGCTCGGGCACAGGTCCCCGCTGCC
GCAGCCCTACCGAGTGAAGCACTGAGCGCGGCGCCGCTTCGCCATCACCTGGCTCTGGCCCTCTCACCCTAGCGTAGGGGGGCACTGGCC
AGGCAGTGAGGACCCTGAGATCCATGCCCTGGGAGACAGAGGTTGTCTCCTGTCCATGCACCCGCGCGCCTGCCTTCTAACCTTCATACC
GTTGGGCAGATTAATTCACTGGACTAGGCCTCTGTTCCGTGGGAGTTGAAAAGATTTGACCTGGAAGAAACCCTAGCGATTATTCAGTTA
AGCCGCAACCCCACCCCCTGTTTTATATAGGGATTCCGGTTCACAATGGATGCTGATAAAGAGAAAGATTTGCAGAAATTTCTTAAAAAT
GTGGATGAAATCTCCAATTTAATTCAGGAGATGAATTCTGATGACCCAGTTGTGCAACAGAAAGCTGTCCTGGAGACAGAAAAGAGACTA
CTGCTTATGGAGGAAGACCAGGAGGAGGATGAATGCAGGACCACCTTGAACAAGACTATGATCAGTCCTCCACAAACTGCTATGAAGAGT
GCAGAAGAAATAAACTCAGAGGCCTTCTTGGCATCTGTGGAGAAGGATGCAAAGGAACGAGCCAAGAGAAGAAGGGAAAACAAAGTCTTG
GCGGATGCCCTAAAAGAAAAAGGGAATGAAGCATTTGCTGAAGGCAATTATGAAACAGCTATCCTGCGCTACAGTGAGGGTTTGGAGAAG
CTGAAGGACATGAAAGTGCTGTACACCAACCGAGCCCAGGCTTATATGAAACTTGAGGACTATGAGAAGGCACTGGTGGATTGTGAGTGG
GCTCTCAAGTGTGATGAAAAATGCACAAAAGCATATTTTCACATGGGAAAAGCCAACCTGGCCCTGAAGAACTACAGTGTGTCTAGAGAG
TGTTATAAGAAGATCTTAGAAATAAACCCCAAGCTGCAAACCCAGGTGAAAGGTTACCTGAATCAAGTAGATCTTCAGGAAAAAGCAGAC
CTTCAAGAAAAGGAAGCCCACGAACTGCTGGATTCAGGAAAGAACACAGCCGTGACCACCAAGAACCTCCTGGAGACCCTTTCCAAGCCT
GACCAGATCCCCTTGTTCTATGCTGGGGGGATTGAGATCCTGACTGAAATGATAAATGAGTGCACAGAACAAACTTTATTCAGAATGCAC
AATGGATTTAGTATCATCAGTGACAACGAGGTCATAAGAAGGTGTTTTTCCACAGCAGGAAATGATGCAGTTGAAGAAATGGTCTGTGTG
TCTGTTCTCAAGCTCTGGCAAGCAGTGTGCAGCAGGAACGAGGAAAACCAGCGTGTGCTAGTGATACACCATGACAGGGCCAGGCTGTTG
GCCGCCCTCTTGTCCTCCAAGGTCCTGGCCATCCGGCAGCAGAGCTTTGCCCTGCTGCTGCATCTCGCCCAGACTGAGAGCGGACGGAGC
CTGATCATCAACCACCTTGACCTGACCAGGTCCCGATCACACAGCAAGAATCCAAAAAGATCCAGGTCCAGAGAGCATCGCAGACATCGA
TCTCGCTCCATGTCACGTGAACGCAAGAGGAGAACTCGATCCAAATCTCGGGAGAAACGCCATCGCCACAGGTCCCGCTCCAGCAGCCGT
AGCCGCAGCCGTAGCCACCAGAGAAGTCGGCACAGTTCTAGAGATAGGAGCAGAGAACGATCCAAGAGGAGATCCTCAAAAGAAAGATTC
AGAGACCAAGACTTAGCATCATGTGACAGAGACAGGAGTTCAAGAGACAGATCACCTCGTGACAGAGATCGGAAAGATAAGAAGCGGTCC
TATGAGAGTGCTAATGGCAGATCAGAAGACAGGAGGAGCTCTGAAGAGCGCGAAGCAGGGGAGATCTAACTAGCTGTGTACATTTCTTCA
GTCCTTAAGCTTCCTACGGAGTTACGTACTATTGTTTAGTTCACAGCTGTTCAGGGTGACAGTGAGCAGATCCAGACACCAGATCCAGCT
AGGCTAGATGTACAGTATCTAACTTGATCTGAACTGAACCTGTTTTCCTTGATGATGCCTAAAACTACATCCATAGTTTCTGGTGAACCT

>94893_94893_2_TTC12-LUC7L2_TTC12_chr11_113215162_ENST00000393020_LUC7L2_chr7_139097297_ENST00000541515_length(amino acids)=517AA_BP=384
MDADKEKDLQKFLKNVDEISNLIQEMNSDDPVVQQKAVLETEKRLLLMEEDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEK
DAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHM
GKANLALKNYSVSRECYKKILEINPKLQTQVKGYLNQVDLQEKADLQEKEAHELLDSGKNTAVTTKNLLETLSKPDQIPLFYAGGIEILT
EMINECTEQTLFRMHNGFSIISDNEVIRRCFSTAGNDAVEEMVCVSVLKLWQAVCSRNEENQRVLVIHHDRARLLAALLSSKVLAIRQQS
FALLLHLAQTESGRSLIINHLDLTRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRSRHSSRD

--------------------------------------------------------------
>94893_94893_3_TTC12-LUC7L2_TTC12_chr11_113215162_ENST00000483239_LUC7L2_chr7_139097297_ENST00000541515_length(transcript)=1848nt_BP=1189nt
AGGGATTCCGGTTCACAATGGATGCTGATAAAGAGAAAGATTTGCAGAAATTTCTTAAAAATGTGGATGAAATCTCCAATTTAATTCAGG
AGATGAATTCTGATGACCCAGTTGTGCAACAGAAAGCTGTCCTGGAGACAGAAAAGAGACTACTGCTTATGGAGGAAGACCAGGAGGAGG
ATGAATGCAGGACCACCTTGAACAAGACTATGATCAGTCCTCCACAAACTGCTATGAAGAGTGCAGAAGAAATAAACTCAGAGGCCTTCT
TGGCATCTGTGGAGAAGGATGCAAAGGAACGAGCCAAGAGAAGAAGGGAAAACAAAGTCTTGGCGGATGCCCTAAAAGAAAAAGGGAATG
AAGCATTTGCTGAAGGCAATTATGAAACAGCTATCCTGCGCTACAGTGAGGGTTTGGAGAAGCTGAAGGACATGAAAGTGCTGTACACCA
ACCGAGCCCAGGCTTATATGAAACTTGAGGACTATGAGAAGGCACTGGTGGATTGTGAGTGGGCTCTCAAGTCATTCTCTTTTATGCAGT
GTGATGAAAAATGCACAAAAGCATATTTTCACATGGGAAAAGCCAACCTGGCCCTGAAGAACTACAGTGTGTCTAGAGAGTGTTATAAGA
AGATCTTAGAAATAAACCCCAAGCTGCAAACCCAGGTGAAAGGTTACCTGAATCAAGTAGATCTTCAGGAAAAAGCAGACCTTCAAGAAA
AGGAAGCCCACGAACTGCTGGATTCAGGAAAGAACACAGCCGTGACCACCAAGAACCTCCTGGAGACCCTTTCCAAGCCTGACCAGATCC
CCTTGTTCTATGCTGGGGGGATTGAGATCCTGACTGAAATGATAAATGAGTGCACAGAACAAACTTTATTCAGAATGCACAATGGATTTA
GTATCATCAGTGACAACGAGGTCATAAGAAGGTGTTTTTCCACAGCAGGAAATGATGCAGTTGAAGAAATGGTCTGTGTGTCTGTTCTCA
AGCTCTGGCAAGCAGTGTGCAGCAGGAACGAGGAAAACCAGCGTGTGCTAGTGATACACCATGACAGGGCCAGGCTGTTGGCCGCCCTCT
TGTCCTCCAAGGTCCTGGCCATCCGGCAGCAGAGCTTTGCCCTGCTGCTGCATCTCGCCCAGACTGAGAGCGGACGGAGCCTGATCATCA
ACCACCTTGACCTGACCAGGTCCCGATCACACAGCAAGAATCCAAAAAGATCCAGGTCCAGAGAGCATCGCAGACATCGATCTCGCTCCA
TGTCACGTGAACGCAAGAGGAGAACTCGATCCAAATCTCGGGAGAAACGCCATCGCCACAGGTCCCGCTCCAGCAGCCGTAGCCGCAGCC
GTAGCCACCAGAGAAGTCGGCACAGTTCTAGAGATAGGAGCAGAGAACGATCCAAGAGGAGATCCTCAAAAGAAAGATTCAGAGACCAAG
ACTTAGCATCATGTGACAGAGACAGGAGTTCAAGAGACAGATCACCTCGTGACAGAGATCGGAAAGATAAGAAGCGGTCCTATGAGAGTG
CTAATGGCAGATCAGAAGACAGGAGGAGCTCTGAAGAGCGCGAAGCAGGGGAGATCTAACTAGCTGTGTACATTTCTTCAGTCCTTAAGC
TTCCTACGGAGTTACGTACTATTGTTTAGTTCACAGCTGTTCAGGGTGACAGTGAGCAGATCCAGACACCAGATCCAGCTAGGCTAGATG
TACAGTATCTAACTTGATCTGAACTGAACCTGTTTTCCTTGATGATGCCTAAAACTACATCCATAGTTTCTGGTGAACCTGTAATACAGT

>94893_94893_3_TTC12-LUC7L2_TTC12_chr11_113215162_ENST00000483239_LUC7L2_chr7_139097297_ENST00000541515_length(amino acids)=523AA_BP=390
MDADKEKDLQKFLKNVDEISNLIQEMNSDDPVVQQKAVLETEKRLLLMEEDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEK
DAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSFSFMQCDEKCT
KAYFHMGKANLALKNYSVSRECYKKILEINPKLQTQVKGYLNQVDLQEKADLQEKEAHELLDSGKNTAVTTKNLLETLSKPDQIPLFYAG
GIEILTEMINECTEQTLFRMHNGFSIISDNEVIRRCFSTAGNDAVEEMVCVSVLKLWQAVCSRNEENQRVLVIHHDRARLLAALLSSKVL
AIRQQSFALLLHLAQTESGRSLIINHLDLTRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRS

--------------------------------------------------------------
>94893_94893_4_TTC12-LUC7L2_TTC12_chr11_113215162_ENST00000529221_LUC7L2_chr7_139097297_ENST00000541515_length(transcript)=1918nt_BP=1259nt
CTTGGTCCCGCCCCGGGCCCCTGGCTCCTGGCCCCGCCCCAGCCCAGGCAGGTCACTGCGCCATTTCCTGTCCAAAGCTGGGCGAATCAG
GGATTCCGGTTCACAATGGATGCTGATAAAGAGAAAGATTTGCAGAAATTTCTTAAAAATGTGGATGAAATCTCCAATTTAATTCAGGAG
ATGAATTCTGATGACCCAGTTGTGCAACAGAAAGCTGTCCTGGAGACAGAAAAGAGACTACTGCTTATGGAGGAAGACCAGGAGGAGGAT
GAATGCAGGACCACCTTGAACAAGACTATGATCAGTCCTCCACAAACTGCTATGAAGAGTGCAGAAGAAATAAACTCAGAGGCCTTCTTG
GCATCTGTGGAGAAGGATGCAAAGGAACGAGCCAAGAGAAGAAGGGAAAACAAAGTCTTGGCGGATGCCCTAAAAGAAAAAGGGAATGAA
GCATTTGCTGAAGGCAATTATGAAACAGCTATCCTGCGCTACAGTGAGGGTTTGGAGAAGCTGAAGGACATGAAAGTGCTGTACACCAAC
CGAGCCCAGGCTTATATGAAACTTGAGGACTATGAGAAGGCACTGGTGGATTGTGAGTGGGCTCTCAAGTGTGATGAAAAATGCACAAAA
GCATATTTTCACATGGGAAAAGCCAACCTGGCCCTGAAGAACTACAGTGTGTCTAGAGAGTGTTATAAGAAGATCTTAGAAATAAACCCC
AAGCTGCAAACCCAGGTGAAAGGTTACCTGAATCAAGTAGATCTTCAGGAAAAAGCAGACCTTCAAGAAAAGGAAGCCCACGAACTGCTG
GATTCAGGAAAGAACACAGCCGTGACCACCAAGAACCTCCTGGAGACCCTTTCCAAGCCTGACCAGATCCCCTTGTTCTATGCTGGGGGG
ATTGAGATCCTGACTGAAATGATAAATGAGTGCACAGAACAAACTTTATTCAGAATGCACAATGGATTTAGTATCATCAGTGACAACGAG
GTCATAAGAAGGTGTTTTTCCACAGCAGGAAATGATGCAGTTGAAGAAATGGTCTGTGTGTCTGTTCTCAAGCTCTGGCAAGCAGTGTGC
AGCAGGAACGAGGAAAACCAGCGTGTGCTAGTGATACACCATGACAGGGCCAGGCTGTTGGCCGCCCTCTTGTCCTCCAAGGTCCTGGCC
ATCCGGCAGCAGAGCTTTGCCCTGCTGCTGCATCTCGCCCAGACTGAGAGCGGACGGAGCCTGATCATCAACCACCTTGACCTGACCAGG
TCCCGATCACACAGCAAGAATCCAAAAAGATCCAGGTCCAGAGAGCATCGCAGACATCGATCTCGCTCCATGTCACGTGAACGCAAGAGG
AGAACTCGATCCAAATCTCGGGAGAAACGCCATCGCCACAGGTCCCGCTCCAGCAGCCGTAGCCGCAGCCGTAGCCACCAGAGAAGTCGG
CACAGTTCTAGAGATAGGAGCAGAGAACGATCCAAGAGGAGATCCTCAAAAGAAAGATTCAGAGACCAAGACTTAGCATCATGTGACAGA
GACAGGAGTTCAAGAGACAGATCACCTCGTGACAGAGATCGGAAAGATAAGAAGCGGTCCTATGAGAGTGCTAATGGCAGATCAGAAGAC
AGGAGGAGCTCTGAAGAGCGCGAAGCAGGGGAGATCTAACTAGCTGTGTACATTTCTTCAGTCCTTAAGCTTCCTACGGAGTTACGTACT
ATTGTTTAGTTCACAGCTGTTCAGGGTGACAGTGAGCAGATCCAGACACCAGATCCAGCTAGGCTAGATGTACAGTATCTAACTTGATCT
GAACTGAACCTGTTTTCCTTGATGATGCCTAAAACTACATCCATAGTTTCTGGTGAACCTGTAATACAGTTCTGAAAGTACAGTTTTATA

>94893_94893_4_TTC12-LUC7L2_TTC12_chr11_113215162_ENST00000529221_LUC7L2_chr7_139097297_ENST00000541515_length(amino acids)=543AA_BP=410
MAPPQPRQVTAPFPVQSWANQGFRFTMDADKEKDLQKFLKNVDEISNLIQEMNSDDPVVQQKAVLETEKRLLLMEEDQEEDECRTTLNKT
MISPPQTAMKSAEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLE
DYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPKLQTQVKGYLNQVDLQEKADLQEKEAHELLDSGKNTAVT
TKNLLETLSKPDQIPLFYAGGIEILTEMINECTEQTLFRMHNGFSIISDNEVIRRCFSTAGNDAVEEMVCVSVLKLWQAVCSRNEENQRV
LVIHHDRARLLAALLSSKVLAIRQQSFALLLHLAQTESGRSLIINHLDLTRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREK
RHRHRSRSSSRSRSRSHQRSRHSSRDRSRERSKRRSSKERFRDQDLASCDRDRSSRDRSPRDRDRKDKKRSYESANGRSEDRRSSEEREA

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Fusion Gene PPI Analysis for TTC12-LUC7L2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TTC12-LUC7L2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TTC12-LUC7L2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source