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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTC19-PIGL (FusionGDB2 ID:94924)

Fusion Gene Summary for TTC19-PIGL

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC19-PIGL
Fusion gene ID: 94924
HgeneTgene
Gene symbol

TTC19

PIGL

Gene ID

54902

9487

Gene nametetratricopeptide repeat domain 19phosphatidylinositol glycan anchor biosynthesis class L
Synonyms2010204O13Rik|MC3DN2CHIME
Cytomap

17p12

17p11.2

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 19, mitochondrialTPR repeat protein 19N-acetylglucosaminyl-phosphatidylinositol de-N-acetylaseN-acetylglucosaminylphosphatidylinositol deacetylasePIG-Lphosphatidylinositol glycan, class Lphosphatidylinositol-glycan biosynthesis class L protein
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000497842, ENST00000261647, 
ENST00000486880, 		ENST00000225609, 
ENST00000395844, ENST00000498772, 
ENST00000581006, ENST00000463810, 
Fusion gene scores* DoF score12 X 8 X 8=7688 X 7 X 7=392
# samples 1410
** MAII scorelog2(14/768*10)=-2.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTC19 [Title/Abstract] AND PIGL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTC19(15909882)-PIGL(16203202), # samples:1
TTC19(15909882)-PIGL(16137285), # samples:1
Anticipated loss of major functional domain due to fusion event.TTC19-PIGL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TTC19-PIGL seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TTC19 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PIGL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-IQ-A6SGTTC19chr17

15909882

+PIGLchr17

16203202

+
ChimerDB4STADTCGA-BR-7716-01ATTC19chr17

15909882

+PIGLchr17

16137285

+


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Fusion Gene ORF analysis for TTC19-PIGL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497842ENST00000225609TTC19chr17

15909882

+PIGLchr17

16203202

+
3UTR-3CDSENST00000497842ENST00000225609TTC19chr17

15909882

+PIGLchr17

16137285

+
3UTR-3CDSENST00000497842ENST00000395844TTC19chr17

15909882

+PIGLchr17

16203202

+
3UTR-3CDSENST00000497842ENST00000395844TTC19chr17

15909882

+PIGLchr17

16137285

+
3UTR-3CDSENST00000497842ENST00000498772TTC19chr17

15909882

+PIGLchr17

16203202

+
3UTR-3CDSENST00000497842ENST00000498772TTC19chr17

15909882

+PIGLchr17

16137285

+
3UTR-3CDSENST00000497842ENST00000581006TTC19chr17

15909882

+PIGLchr17

16203202

+
3UTR-3CDSENST00000497842ENST00000581006TTC19chr17

15909882

+PIGLchr17

16137285

+
3UTR-intronENST00000497842ENST00000463810TTC19chr17

15909882

+PIGLchr17

16203202

+
3UTR-intronENST00000497842ENST00000463810TTC19chr17

15909882

+PIGLchr17

16137285

+
5CDS-intronENST00000261647ENST00000463810TTC19chr17

15909882

+PIGLchr17

16203202

+
5CDS-intronENST00000261647ENST00000463810TTC19chr17

15909882

+PIGLchr17

16137285

+
5CDS-intronENST00000486880ENST00000463810TTC19chr17

15909882

+PIGLchr17

16203202

+
5CDS-intronENST00000486880ENST00000463810TTC19chr17

15909882

+PIGLchr17

16137285

+
Frame-shiftENST00000261647ENST00000225609TTC19chr17

15909882

+PIGLchr17

16203202

+
Frame-shiftENST00000261647ENST00000395844TTC19chr17

15909882

+PIGLchr17

16203202

+
Frame-shiftENST00000261647ENST00000498772TTC19chr17

15909882

+PIGLchr17

16203202

+
Frame-shiftENST00000261647ENST00000581006TTC19chr17

15909882

+PIGLchr17

16203202

+
Frame-shiftENST00000486880ENST00000225609TTC19chr17

15909882

+PIGLchr17

16203202

+
Frame-shiftENST00000486880ENST00000395844TTC19chr17

15909882

+PIGLchr17

16203202

+
Frame-shiftENST00000486880ENST00000498772TTC19chr17

15909882

+PIGLchr17

16203202

+
Frame-shiftENST00000486880ENST00000581006TTC19chr17

15909882

+PIGLchr17

16203202

+
In-frameENST00000261647ENST00000225609TTC19chr17

15909882

+PIGLchr17

16137285

+
In-frameENST00000261647ENST00000395844TTC19chr17

15909882

+PIGLchr17

16137285

+
In-frameENST00000261647ENST00000498772TTC19chr17

15909882

+PIGLchr17

16137285

+
In-frameENST00000261647ENST00000581006TTC19chr17

15909882

+PIGLchr17

16137285

+
In-frameENST00000486880ENST00000225609TTC19chr17

15909882

+PIGLchr17

16137285

+
In-frameENST00000486880ENST00000395844TTC19chr17

15909882

+PIGLchr17

16137285

+
In-frameENST00000486880ENST00000498772TTC19chr17

15909882

+PIGLchr17

16137285

+
In-frameENST00000486880ENST00000581006TTC19chr17

15909882

+PIGLchr17

16137285

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261647TTC19chr1715909882+ENST00000581006PIGLchr1716137285+144611451061362418
ENST00000261647TTC19chr1715909882+ENST00000498772PIGLchr1716137285+183911451061494462
ENST00000261647TTC19chr1715909882+ENST00000225609PIGLchr1716137285+203011451061668520
ENST00000261647TTC19chr1715909882+ENST00000395844PIGLchr1716137285+215011451061644512
ENST00000486880TTC19chr1715909882+ENST00000581006PIGLchr1716137285+13581057181274418
ENST00000486880TTC19chr1715909882+ENST00000498772PIGLchr1716137285+17511057181406462
ENST00000486880TTC19chr1715909882+ENST00000225609PIGLchr1716137285+19421057181580520
ENST00000486880TTC19chr1715909882+ENST00000395844PIGLchr1716137285+20621057181556512

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261647ENST00000581006TTC19chr1715909882+PIGLchr1716137285+0.0112900860.98870987
ENST00000261647ENST00000498772TTC19chr1715909882+PIGLchr1716137285+0.017617540.9823825
ENST00000261647ENST00000225609TTC19chr1715909882+PIGLchr1716137285+0.0204901550.9795099
ENST00000261647ENST00000395844TTC19chr1715909882+PIGLchr1716137285+0.0279216490.9720783
ENST00000486880ENST00000581006TTC19chr1715909882+PIGLchr1716137285+0.0123080590.98769194
ENST00000486880ENST00000498772TTC19chr1715909882+PIGLchr1716137285+0.0193211830.9806788
ENST00000486880ENST00000225609TTC19chr1715909882+PIGLchr1716137285+0.0218812080.9781188
ENST00000486880ENST00000395844TTC19chr1715909882+PIGLchr1716137285+0.0293419320.9706581

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Fusion Genomic Features for TTC19-PIGL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TTC19chr1715909882+PIGLchr1716137284+0.92624680.07375315
TTC19chr1715909882+PIGLchr1716203201+1.21E-060.9999988
TTC19chr1715909882+PIGLchr1716137284+0.92624680.07375315
TTC19chr1715909882+PIGLchr1716203201+1.21E-060.9999988

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TTC19-PIGL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:15909882/chr17:16203202)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC19chr17:15909882chr17:16137285ENST00000261647+71073_76225381.0Compositional biasNote=Poly-Glu
HgeneTTC19chr17:15909882chr17:16137285ENST00000486880+71073_76346502.0Compositional biasNote=Poly-Glu
HgeneTTC19chr17:15909882chr17:16137285ENST00000261647+710136_169225381.0RepeatNote=TPR 1
HgeneTTC19chr17:15909882chr17:16137285ENST00000261647+710179_212225381.0RepeatNote=TPR 2
HgeneTTC19chr17:15909882chr17:16137285ENST00000486880+710136_169346502.0RepeatNote=TPR 1
HgeneTTC19chr17:15909882chr17:16137285ENST00000486880+710179_212346502.0RepeatNote=TPR 2
HgeneTTC19chr17:15909882chr17:16137285ENST00000486880+710237_270346502.0RepeatNote=TPR 3
HgeneTTC19chr17:15909882chr17:16137285ENST00000486880+710279_312346502.0RepeatNote=TPR 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC19chr17:15909882chr17:16137285ENST00000261647+710237_270225381.0RepeatNote=TPR 3
HgeneTTC19chr17:15909882chr17:16137285ENST00000261647+710279_312225381.0RepeatNote=TPR 4
HgeneTTC19chr17:15909882chr17:16137285ENST00000261647+710318_351225381.0RepeatNote=TPR 5
HgeneTTC19chr17:15909882chr17:16137285ENST00000486880+710318_351346502.0RepeatNote=TPR 5
TgenePIGLchr17:15909882chr17:16137285ENST000002256090723_25278253.0Topological domainCytoplasmic
TgenePIGLchr17:15909882chr17:16137285ENST00000225609072_2278253.0TransmembraneHelical


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Fusion Gene Sequence for TTC19-PIGL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94924_94924_1_TTC19-PIGL_TTC19_chr17_15909882_ENST00000261647_PIGL_chr17_16137285_ENST00000225609_length(transcript)=2030nt_BP=1145nt
CGAACAAGAGGTTTAGAGAACCACATGGAAAAAAGGCAGGGCCAGGCCCGGACACCCCGCCTCCTGCCTCCCGGCCCGGCGGTGCCCGGA
TGCCCCGCCCGCGCCCATGGCGCAGCCACACACGACCTCGGTCCCGTACTTCGCGCGCTCTCCTGCACCGCCGCCGCCATCTCGCTCAGG
AGCTCCTCCACAACCGCCGGCAACACTACGGCCATCGCGCCGCAGGACACGCCCTCCACGACCGGCGGACCGCCGCGACGCTCCAGCTGA
CTGCGCCTACCTGTGGAGGATCCTGACCCCCCGCCGGGGCAGGGCGAGACGGAGTGACGTCGGGGCGCGTCATCGCGCGTGCGGACGCAG
GGATGTCCTGCTCAGTCGTCAGGGCCCGGCCAATCCGGAGGGCGCTCGGCGCGTGGTCGGGGGCCAGGAGCGCGTCTGGCCTGCAGTGCG
CAGAGGACGCGGCGGGAGCATGTTCCGGCTCCTGAGCTGGAGCCTGGGCCGAGGCTTCCTGCGGGCCGCGGGGCGGCGGTGCCGGGGCTG
CTCCGCGCGCCTGCTCCCGGGGCTGGCAGGAGGTCCGGGGCCCGAGGTGCAGGTGCCGCCATCCCGAGTCGCGCCGCACGGCCGGGGCCC
AGGCCTGCTGCCGCTGCTGGCAGCGCTCGCCTGGTTCTCGAGGCCCGCTGCGGCAGAGGAGGAGGAGCAGCAGGGAGCCGACGGGGCCGC
TGCCGAGGACGGGGCGGACGAGGCCGAGGCAGAGATCATCCAGCTGCTGAAGCGAGCCAAGTTGAGCATTATGAAAGATGAGCCAGAAGA
GGCTGAGTTAATTTTGCATGACGCTCTTCGTCTCGCCTATCAGACTGATAACAAGAAGGCCATCACTTACACTTATGATTTGATGGCCAA
CTTAGCATTTATACGGGGTCAGCTTGAAAATGCTGAACAACTTTTTAAAGCAACAATGAGTTACCTCCTTGGAGGGGGCATGAAGCAGGA
GGACAATGCAATAATTGAAATTTCCCTAAAGCTGGCCAGTATCTATGCTGCGCAGAACAGACAGGAATTTGCTGTTGCTGGCTATGAATT
CTGCATTTCAACTCTAGAGGAAAAAATTGAAAGAGAAAAGGAATTAGCAGAAGACATTATGTCAGGAAATTACTACAATCAAGGAGAGAC
TCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGATGA
CCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTCGA
TGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGGTG
CTCTGTGCTCACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCTTCATACGCAGGATGT
CCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTA
CATTATCTTCTCCCGGTACATGAGAATCAACTCACTGAGCTTCCTCTGAAGCCTTGAAGGGTTTTCAGATCCAAGGAACAAAGGGGAAAA
TAGACAAAGGAGTGCAGAGGACCTGGCCTGGCACTGGCTTATTTACCTGAGCTCAAGGAGATCCCCGCTGGAGCAGCCTCTGCAAAAGGG
AGCCCATGTAGGCCAGGGGCTGTCCAAACTCCAGCTTCTTCCCCTGGGAAAAAACCCAAAGAACCAAAAACAAACCACCCCAAGGATAAT
AATAGCTACACTGCTAGCTTCTCAAGTTCTTGTGAAAAACAATTTACATAATGACACAGTAGATGTGGAACACCTAGCCCAGTGCCTGGG

>94924_94924_1_TTC19-PIGL_TTC19_chr17_15909882_ENST00000261647_PIGL_chr17_16137285_ENST00000225609_length(amino acids)=520AA_BP=0
MAQPHTTSVPYFARSPAPPPPSRSGAPPQPPATLRPSRRRTRPPRPADRRDAPADCAYLWRILTPRRGRARRSDVGARHRACGRRDVLLS
RQGPANPEGARRVVGGQERVWPAVRRGRGGSMFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPL
LAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIR
GQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSGNYYNQGETRKKEL
LQSCDVLGIPLSSVMIIDNRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGCSVLTL

--------------------------------------------------------------
>94924_94924_2_TTC19-PIGL_TTC19_chr17_15909882_ENST00000261647_PIGL_chr17_16137285_ENST00000395844_length(transcript)=2150nt_BP=1145nt
CGAACAAGAGGTTTAGAGAACCACATGGAAAAAAGGCAGGGCCAGGCCCGGACACCCCGCCTCCTGCCTCCCGGCCCGGCGGTGCCCGGA
TGCCCCGCCCGCGCCCATGGCGCAGCCACACACGACCTCGGTCCCGTACTTCGCGCGCTCTCCTGCACCGCCGCCGCCATCTCGCTCAGG
AGCTCCTCCACAACCGCCGGCAACACTACGGCCATCGCGCCGCAGGACACGCCCTCCACGACCGGCGGACCGCCGCGACGCTCCAGCTGA
CTGCGCCTACCTGTGGAGGATCCTGACCCCCCGCCGGGGCAGGGCGAGACGGAGTGACGTCGGGGCGCGTCATCGCGCGTGCGGACGCAG
GGATGTCCTGCTCAGTCGTCAGGGCCCGGCCAATCCGGAGGGCGCTCGGCGCGTGGTCGGGGGCCAGGAGCGCGTCTGGCCTGCAGTGCG
CAGAGGACGCGGCGGGAGCATGTTCCGGCTCCTGAGCTGGAGCCTGGGCCGAGGCTTCCTGCGGGCCGCGGGGCGGCGGTGCCGGGGCTG
CTCCGCGCGCCTGCTCCCGGGGCTGGCAGGAGGTCCGGGGCCCGAGGTGCAGGTGCCGCCATCCCGAGTCGCGCCGCACGGCCGGGGCCC
AGGCCTGCTGCCGCTGCTGGCAGCGCTCGCCTGGTTCTCGAGGCCCGCTGCGGCAGAGGAGGAGGAGCAGCAGGGAGCCGACGGGGCCGC
TGCCGAGGACGGGGCGGACGAGGCCGAGGCAGAGATCATCCAGCTGCTGAAGCGAGCCAAGTTGAGCATTATGAAAGATGAGCCAGAAGA
GGCTGAGTTAATTTTGCATGACGCTCTTCGTCTCGCCTATCAGACTGATAACAAGAAGGCCATCACTTACACTTATGATTTGATGGCCAA
CTTAGCATTTATACGGGGTCAGCTTGAAAATGCTGAACAACTTTTTAAAGCAACAATGAGTTACCTCCTTGGAGGGGGCATGAAGCAGGA
GGACAATGCAATAATTGAAATTTCCCTAAAGCTGGCCAGTATCTATGCTGCGCAGAACAGACAGGAATTTGCTGTTGCTGGCTATGAATT
CTGCATTTCAACTCTAGAGGAAAAAATTGAAAGAGAAAAGGAATTAGCAGAAGACATTATGTCAGGAAATTACTACAATCAAGGAGAGAC
TCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGATGA
CCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTCGA
TGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGTGCTCTGTGCTCACGCTTCAGTCTGTGAATGTGC
TGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCAC
AGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTATCTTCTCCCGGTACATGAGAATCAACT
CACTGAGCTTCCTCTGAAGCCTTGAAGGGTTTTCAGATCCAAGGAACAAAGGGGAAAATAGACAAAGGAGTGCAGAGGACCTGGCCTGGC
ACTGGCTTATTTACCTGAGCTCAAGGAGATCCCCGCTGGAGCAGCCTCTGCAAAAGGGAGCCCATGTAGGCCAGGGGCTGTCCAAACTCC
AGCTTCTTCCCCTGGGAAAAAACCCAAAGAACCAAAAACAAACCACCCCAAGGATAATAATAGCTACACTGCTAGCTTCTCAAGTTCTTG
TGAAAAACAATTTACATAATGACACAGTAGATGTGGAACACCTAGCCCAGTGCCTGGGCAGGTCCCTATTATCATAAATGAACATAAAAG
TGCTCTAAAAACACTCCACAGATGTGACTTTTACATTGTTTCCAAAGCAGGTTCACCAAAAACACATACACAAAATGCAACAGTGTGTGT

>94924_94924_2_TTC19-PIGL_TTC19_chr17_15909882_ENST00000261647_PIGL_chr17_16137285_ENST00000395844_length(amino acids)=512AA_BP=0
MAQPHTTSVPYFARSPAPPPPSRSGAPPQPPATLRPSRRRTRPPRPADRRDAPADCAYLWRILTPRRGRARRSDVGARHRACGRRDVLLS
RQGPANPEGARRVVGGQERVWPAVRRGRGGSMFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPL
LAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIR
GQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSGNYYNQGETRKKEL
LQSCDVLGIPLSSVMIIDNRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRVLCAHASVCECAAQVHL

--------------------------------------------------------------
>94924_94924_3_TTC19-PIGL_TTC19_chr17_15909882_ENST00000261647_PIGL_chr17_16137285_ENST00000498772_length(transcript)=1839nt_BP=1145nt
CGAACAAGAGGTTTAGAGAACCACATGGAAAAAAGGCAGGGCCAGGCCCGGACACCCCGCCTCCTGCCTCCCGGCCCGGCGGTGCCCGGA
TGCCCCGCCCGCGCCCATGGCGCAGCCACACACGACCTCGGTCCCGTACTTCGCGCGCTCTCCTGCACCGCCGCCGCCATCTCGCTCAGG
AGCTCCTCCACAACCGCCGGCAACACTACGGCCATCGCGCCGCAGGACACGCCCTCCACGACCGGCGGACCGCCGCGACGCTCCAGCTGA
CTGCGCCTACCTGTGGAGGATCCTGACCCCCCGCCGGGGCAGGGCGAGACGGAGTGACGTCGGGGCGCGTCATCGCGCGTGCGGACGCAG
GGATGTCCTGCTCAGTCGTCAGGGCCCGGCCAATCCGGAGGGCGCTCGGCGCGTGGTCGGGGGCCAGGAGCGCGTCTGGCCTGCAGTGCG
CAGAGGACGCGGCGGGAGCATGTTCCGGCTCCTGAGCTGGAGCCTGGGCCGAGGCTTCCTGCGGGCCGCGGGGCGGCGGTGCCGGGGCTG
CTCCGCGCGCCTGCTCCCGGGGCTGGCAGGAGGTCCGGGGCCCGAGGTGCAGGTGCCGCCATCCCGAGTCGCGCCGCACGGCCGGGGCCC
AGGCCTGCTGCCGCTGCTGGCAGCGCTCGCCTGGTTCTCGAGGCCCGCTGCGGCAGAGGAGGAGGAGCAGCAGGGAGCCGACGGGGCCGC
TGCCGAGGACGGGGCGGACGAGGCCGAGGCAGAGATCATCCAGCTGCTGAAGCGAGCCAAGTTGAGCATTATGAAAGATGAGCCAGAAGA
GGCTGAGTTAATTTTGCATGACGCTCTTCGTCTCGCCTATCAGACTGATAACAAGAAGGCCATCACTTACACTTATGATTTGATGGCCAA
CTTAGCATTTATACGGGGTCAGCTTGAAAATGCTGAACAACTTTTTAAAGCAACAATGAGTTACCTCCTTGGAGGGGGCATGAAGCAGGA
GGACAATGCAATAATTGAAATTTCCCTAAAGCTGGCCAGTATCTATGCTGCGCAGAACAGACAGGAATTTGCTGTTGCTGGCTATGAATT
CTGCATTTCAACTCTAGAGGAAAAAATTGAAAGAGAAAAGGAATTAGCAGAAGACATTATGTCAGGAAATTACTACAATCAAGGAGAGAC
TCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGATGA
CCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTCGA
TGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGTAA
GGCTTGTTCCTTTTGCAAAGGGCCACAAGATACTGTCCCTCTGAGAAACTTATGAGGGGGAAATTTGCAAATCCACAGAGAGCTGCCCTC
AGCCGAGCAGAGGCAGTGGTTGGGGAGGCCGCCACACTCTTCCTGACTCACCTCAAGGTACCTGGCAGGTTGTATCTACCAGCAAGTGCC
TGCCTGCAGGGCCACCTCTGGATGAGTGGGGAGGCCAGGTTTGCCCCTCAACCTGTCTAGCTTTTTCACAGGGTGGATGTTTTACACCTC
TGGTATTCTTCCAGTCTGAACTCAATCCCATCCCCCAACCAATTAGGCAGGTTGTAAATGACTGCTGGGTGCTTGATGAACCAATCTGCC

>94924_94924_3_TTC19-PIGL_TTC19_chr17_15909882_ENST00000261647_PIGL_chr17_16137285_ENST00000498772_length(amino acids)=462AA_BP=0
MAQPHTTSVPYFARSPAPPPPSRSGAPPQPPATLRPSRRRTRPPRPADRRDAPADCAYLWRILTPRRGRARRSDVGARHRACGRRDVLLS
RQGPANPEGARRVVGGQERVWPAVRRGRGGSMFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPL
LAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIR
GQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSGNYYNQGETRKKEL
LQSCDVLGIPLSSVMIIDNRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGKACSFC

--------------------------------------------------------------
>94924_94924_4_TTC19-PIGL_TTC19_chr17_15909882_ENST00000261647_PIGL_chr17_16137285_ENST00000581006_length(transcript)=1446nt_BP=1145nt
CGAACAAGAGGTTTAGAGAACCACATGGAAAAAAGGCAGGGCCAGGCCCGGACACCCCGCCTCCTGCCTCCCGGCCCGGCGGTGCCCGGA
TGCCCCGCCCGCGCCCATGGCGCAGCCACACACGACCTCGGTCCCGTACTTCGCGCGCTCTCCTGCACCGCCGCCGCCATCTCGCTCAGG
AGCTCCTCCACAACCGCCGGCAACACTACGGCCATCGCGCCGCAGGACACGCCCTCCACGACCGGCGGACCGCCGCGACGCTCCAGCTGA
CTGCGCCTACCTGTGGAGGATCCTGACCCCCCGCCGGGGCAGGGCGAGACGGAGTGACGTCGGGGCGCGTCATCGCGCGTGCGGACGCAG
GGATGTCCTGCTCAGTCGTCAGGGCCCGGCCAATCCGGAGGGCGCTCGGCGCGTGGTCGGGGGCCAGGAGCGCGTCTGGCCTGCAGTGCG
CAGAGGACGCGGCGGGAGCATGTTCCGGCTCCTGAGCTGGAGCCTGGGCCGAGGCTTCCTGCGGGCCGCGGGGCGGCGGTGCCGGGGCTG
CTCCGCGCGCCTGCTCCCGGGGCTGGCAGGAGGTCCGGGGCCCGAGGTGCAGGTGCCGCCATCCCGAGTCGCGCCGCACGGCCGGGGCCC
AGGCCTGCTGCCGCTGCTGGCAGCGCTCGCCTGGTTCTCGAGGCCCGCTGCGGCAGAGGAGGAGGAGCAGCAGGGAGCCGACGGGGCCGC
TGCCGAGGACGGGGCGGACGAGGCCGAGGCAGAGATCATCCAGCTGCTGAAGCGAGCCAAGTTGAGCATTATGAAAGATGAGCCAGAAGA
GGCTGAGTTAATTTTGCATGACGCTCTTCGTCTCGCCTATCAGACTGATAACAAGAAGGCCATCACTTACACTTATGATTTGATGGCCAA
CTTAGCATTTATACGGGGTCAGCTTGAAAATGCTGAACAACTTTTTAAAGCAACAATGAGTTACCTCCTTGGAGGGGGCATGAAGCAGGA
GGACAATGCAATAATTGAAATTTCCCTAAAGCTGGCCAGTATCTATGCTGCGCAGAACAGACAGGAATTTGCTGTTGCTGGCTATGAATT
CTGCATTTCAACTCTAGAGGAAAAAATTGAAAGAGAAAAGGAATTAGCAGAAGACATTATGTCAGGAAATTACTACAATCAAGGAGAGAC
TCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGATGA
CCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGAAAGACAGAGCAAA
TTCCAGATTGTGAGCAGCCACCTGCATCCTCTATGCCTGAGCGGCCCAGCCATGAGAGCCAGCCGACCCCACAGATGATGCCCCTTTCAG

>94924_94924_4_TTC19-PIGL_TTC19_chr17_15909882_ENST00000261647_PIGL_chr17_16137285_ENST00000581006_length(amino acids)=418AA_BP=0
MAQPHTTSVPYFARSPAPPPPSRSGAPPQPPATLRPSRRRTRPPRPADRRDAPADCAYLWRILTPRRGRARRSDVGARHRACGRRDVLLS
RQGPANPEGARRVVGGQERVWPAVRRGRGGSMFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPL
LAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIR
GQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSGNYYNQGETRKKEL

--------------------------------------------------------------
>94924_94924_5_TTC19-PIGL_TTC19_chr17_15909882_ENST00000486880_PIGL_chr17_16137285_ENST00000225609_length(transcript)=1942nt_BP=1057nt
GATGCCCCGCCCGCGCCCATGGCGCAGCCACACACGACCTCGGTCCCGTACTTCGCGCGCTCTCCTGCACCGCCGCCGCCATCTCGCTCA
GGAGCTCCTCCACAACCGCCGGCAACACTACGGCCATCGCGCCGCAGGACACGCCCTCCACGACCGGCGGACCGCCGCGACGCTCCAGCT
GACTGCGCCTACCTGTGGAGGATCCTGACCCCCCGCCGGGGCAGGGCGAGACGGAGTGACGTCGGGGCGCGTCATCGCGCGTGCGGACGC
AGGGATGTCCTGCTCAGTCGTCAGGGCCCGGCCAATCCGGAGGGCGCTCGGCGCGTGGTCGGGGGCCAGGAGCGCGTCTGGCCTGCAGTG
CGCAGAGGACGCGGCGGGAGCATGTTCCGGCTCCTGAGCTGGAGCCTGGGCCGAGGCTTCCTGCGGGCCGCGGGGCGGCGGTGCCGGGGC
TGCTCCGCGCGCCTGCTCCCGGGGCTGGCAGGAGGTCCGGGGCCCGAGGTGCAGGTGCCGCCATCCCGAGTCGCGCCGCACGGCCGGGGC
CCAGGCCTGCTGCCGCTGCTGGCAGCGCTCGCCTGGTTCTCGAGGCCCGCTGCGGCAGAGGAGGAGGAGCAGCAGGGAGCCGACGGGGCC
GCTGCCGAGGACGGGGCGGACGAGGCCGAGGCAGAGATCATCCAGCTGCTGAAGCGAGCCAAGTTGAGCATTATGAAAGATGAGCCAGAA
GAGGCTGAGTTAATTTTGCATGACGCTCTTCGTCTCGCCTATCAGACTGATAACAAGAAGGCCATCACTTACACTTATGATTTGATGGCC
AACTTAGCATTTATACGGGGTCAGCTTGAAAATGCTGAACAACTTTTTAAAGCAACAATGAGTTACCTCCTTGGAGGGGGCATGAAGCAG
GAGGACAATGCAATAATTGAAATTTCCCTAAAGCTGGCCAGTATCTATGCTGCGCAGAACAGACAGGAATTTGCTGTTGCTGGCTATGAA
TTCTGCATTTCAACTCTAGAGGAAAAAATTGAAAGAGAAAAGGAATTAGCAGAAGACATTATGTCAGGAAATTACTACAATCAAGGAGAG
ACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGAT
GACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTC
GATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGG
TGCTCTGTGCTCACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCTTCATACGCAGGAT
GTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTC
TACATTATCTTCTCCCGGTACATGAGAATCAACTCACTGAGCTTCCTCTGAAGCCTTGAAGGGTTTTCAGATCCAAGGAACAAAGGGGAA
AATAGACAAAGGAGTGCAGAGGACCTGGCCTGGCACTGGCTTATTTACCTGAGCTCAAGGAGATCCCCGCTGGAGCAGCCTCTGCAAAAG
GGAGCCCATGTAGGCCAGGGGCTGTCCAAACTCCAGCTTCTTCCCCTGGGAAAAAACCCAAAGAACCAAAAACAAACCACCCCAAGGATA
ATAATAGCTACACTGCTAGCTTCTCAAGTTCTTGTGAAAAACAATTTACATAATGACACAGTAGATGTGGAACACCTAGCCCAGTGCCTG

>94924_94924_5_TTC19-PIGL_TTC19_chr17_15909882_ENST00000486880_PIGL_chr17_16137285_ENST00000225609_length(amino acids)=520AA_BP=0
MAQPHTTSVPYFARSPAPPPPSRSGAPPQPPATLRPSRRRTRPPRPADRRDAPADCAYLWRILTPRRGRARRSDVGARHRACGRRDVLLS
RQGPANPEGARRVVGGQERVWPAVRRGRGGSMFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPL
LAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIR
GQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSGNYYNQGETRKKEL
LQSCDVLGIPLSSVMIIDNRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGCSVLTL

--------------------------------------------------------------
>94924_94924_6_TTC19-PIGL_TTC19_chr17_15909882_ENST00000486880_PIGL_chr17_16137285_ENST00000395844_length(transcript)=2062nt_BP=1057nt
GATGCCCCGCCCGCGCCCATGGCGCAGCCACACACGACCTCGGTCCCGTACTTCGCGCGCTCTCCTGCACCGCCGCCGCCATCTCGCTCA
GGAGCTCCTCCACAACCGCCGGCAACACTACGGCCATCGCGCCGCAGGACACGCCCTCCACGACCGGCGGACCGCCGCGACGCTCCAGCT
GACTGCGCCTACCTGTGGAGGATCCTGACCCCCCGCCGGGGCAGGGCGAGACGGAGTGACGTCGGGGCGCGTCATCGCGCGTGCGGACGC
AGGGATGTCCTGCTCAGTCGTCAGGGCCCGGCCAATCCGGAGGGCGCTCGGCGCGTGGTCGGGGGCCAGGAGCGCGTCTGGCCTGCAGTG
CGCAGAGGACGCGGCGGGAGCATGTTCCGGCTCCTGAGCTGGAGCCTGGGCCGAGGCTTCCTGCGGGCCGCGGGGCGGCGGTGCCGGGGC
TGCTCCGCGCGCCTGCTCCCGGGGCTGGCAGGAGGTCCGGGGCCCGAGGTGCAGGTGCCGCCATCCCGAGTCGCGCCGCACGGCCGGGGC
CCAGGCCTGCTGCCGCTGCTGGCAGCGCTCGCCTGGTTCTCGAGGCCCGCTGCGGCAGAGGAGGAGGAGCAGCAGGGAGCCGACGGGGCC
GCTGCCGAGGACGGGGCGGACGAGGCCGAGGCAGAGATCATCCAGCTGCTGAAGCGAGCCAAGTTGAGCATTATGAAAGATGAGCCAGAA
GAGGCTGAGTTAATTTTGCATGACGCTCTTCGTCTCGCCTATCAGACTGATAACAAGAAGGCCATCACTTACACTTATGATTTGATGGCC
AACTTAGCATTTATACGGGGTCAGCTTGAAAATGCTGAACAACTTTTTAAAGCAACAATGAGTTACCTCCTTGGAGGGGGCATGAAGCAG
GAGGACAATGCAATAATTGAAATTTCCCTAAAGCTGGCCAGTATCTATGCTGCGCAGAACAGACAGGAATTTGCTGTTGCTGGCTATGAA
TTCTGCATTTCAACTCTAGAGGAAAAAATTGAAAGAGAAAAGGAATTAGCAGAAGACATTATGTCAGGAAATTACTACAATCAAGGAGAG
ACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGAT
GACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTC
GATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGTGCTCTGTGCTCACGCTTCAGTCTGTGAATGT
GCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGC
ACAGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTATCTTCTCCCGGTACATGAGAATCAA
CTCACTGAGCTTCCTCTGAAGCCTTGAAGGGTTTTCAGATCCAAGGAACAAAGGGGAAAATAGACAAAGGAGTGCAGAGGACCTGGCCTG
GCACTGGCTTATTTACCTGAGCTCAAGGAGATCCCCGCTGGAGCAGCCTCTGCAAAAGGGAGCCCATGTAGGCCAGGGGCTGTCCAAACT
CCAGCTTCTTCCCCTGGGAAAAAACCCAAAGAACCAAAAACAAACCACCCCAAGGATAATAATAGCTACACTGCTAGCTTCTCAAGTTCT
TGTGAAAAACAATTTACATAATGACACAGTAGATGTGGAACACCTAGCCCAGTGCCTGGGCAGGTCCCTATTATCATAAATGAACATAAA
AGTGCTCTAAAAACACTCCACAGATGTGACTTTTACATTGTTTCCAAAGCAGGTTCACCAAAAACACATACACAAAATGCAACAGTGTGT

>94924_94924_6_TTC19-PIGL_TTC19_chr17_15909882_ENST00000486880_PIGL_chr17_16137285_ENST00000395844_length(amino acids)=512AA_BP=0
MAQPHTTSVPYFARSPAPPPPSRSGAPPQPPATLRPSRRRTRPPRPADRRDAPADCAYLWRILTPRRGRARRSDVGARHRACGRRDVLLS
RQGPANPEGARRVVGGQERVWPAVRRGRGGSMFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPL
LAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIR
GQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSGNYYNQGETRKKEL
LQSCDVLGIPLSSVMIIDNRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRVLCAHASVCECAAQVHL

--------------------------------------------------------------
>94924_94924_7_TTC19-PIGL_TTC19_chr17_15909882_ENST00000486880_PIGL_chr17_16137285_ENST00000498772_length(transcript)=1751nt_BP=1057nt
GATGCCCCGCCCGCGCCCATGGCGCAGCCACACACGACCTCGGTCCCGTACTTCGCGCGCTCTCCTGCACCGCCGCCGCCATCTCGCTCA
GGAGCTCCTCCACAACCGCCGGCAACACTACGGCCATCGCGCCGCAGGACACGCCCTCCACGACCGGCGGACCGCCGCGACGCTCCAGCT
GACTGCGCCTACCTGTGGAGGATCCTGACCCCCCGCCGGGGCAGGGCGAGACGGAGTGACGTCGGGGCGCGTCATCGCGCGTGCGGACGC
AGGGATGTCCTGCTCAGTCGTCAGGGCCCGGCCAATCCGGAGGGCGCTCGGCGCGTGGTCGGGGGCCAGGAGCGCGTCTGGCCTGCAGTG
CGCAGAGGACGCGGCGGGAGCATGTTCCGGCTCCTGAGCTGGAGCCTGGGCCGAGGCTTCCTGCGGGCCGCGGGGCGGCGGTGCCGGGGC
TGCTCCGCGCGCCTGCTCCCGGGGCTGGCAGGAGGTCCGGGGCCCGAGGTGCAGGTGCCGCCATCCCGAGTCGCGCCGCACGGCCGGGGC
CCAGGCCTGCTGCCGCTGCTGGCAGCGCTCGCCTGGTTCTCGAGGCCCGCTGCGGCAGAGGAGGAGGAGCAGCAGGGAGCCGACGGGGCC
GCTGCCGAGGACGGGGCGGACGAGGCCGAGGCAGAGATCATCCAGCTGCTGAAGCGAGCCAAGTTGAGCATTATGAAAGATGAGCCAGAA
GAGGCTGAGTTAATTTTGCATGACGCTCTTCGTCTCGCCTATCAGACTGATAACAAGAAGGCCATCACTTACACTTATGATTTGATGGCC
AACTTAGCATTTATACGGGGTCAGCTTGAAAATGCTGAACAACTTTTTAAAGCAACAATGAGTTACCTCCTTGGAGGGGGCATGAAGCAG
GAGGACAATGCAATAATTGAAATTTCCCTAAAGCTGGCCAGTATCTATGCTGCGCAGAACAGACAGGAATTTGCTGTTGCTGGCTATGAA
TTCTGCATTTCAACTCTAGAGGAAAAAATTGAAAGAGAAAAGGAATTAGCAGAAGACATTATGTCAGGAAATTACTACAATCAAGGAGAG
ACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGAT
GACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTC
GATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGT
AAGGCTTGTTCCTTTTGCAAAGGGCCACAAGATACTGTCCCTCTGAGAAACTTATGAGGGGGAAATTTGCAAATCCACAGAGAGCTGCCC
TCAGCCGAGCAGAGGCAGTGGTTGGGGAGGCCGCCACACTCTTCCTGACTCACCTCAAGGTACCTGGCAGGTTGTATCTACCAGCAAGTG
CCTGCCTGCAGGGCCACCTCTGGATGAGTGGGGAGGCCAGGTTTGCCCCTCAACCTGTCTAGCTTTTTCACAGGGTGGATGTTTTACACC
TCTGGTATTCTTCCAGTCTGAACTCAATCCCATCCCCCAACCAATTAGGCAGGTTGTAAATGACTGCTGGGTGCTTGATGAACCAATCTG

>94924_94924_7_TTC19-PIGL_TTC19_chr17_15909882_ENST00000486880_PIGL_chr17_16137285_ENST00000498772_length(amino acids)=462AA_BP=0
MAQPHTTSVPYFARSPAPPPPSRSGAPPQPPATLRPSRRRTRPPRPADRRDAPADCAYLWRILTPRRGRARRSDVGARHRACGRRDVLLS
RQGPANPEGARRVVGGQERVWPAVRRGRGGSMFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPL
LAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIR
GQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSGNYYNQGETRKKEL
LQSCDVLGIPLSSVMIIDNRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGKACSFC

--------------------------------------------------------------
>94924_94924_8_TTC19-PIGL_TTC19_chr17_15909882_ENST00000486880_PIGL_chr17_16137285_ENST00000581006_length(transcript)=1358nt_BP=1057nt
GATGCCCCGCCCGCGCCCATGGCGCAGCCACACACGACCTCGGTCCCGTACTTCGCGCGCTCTCCTGCACCGCCGCCGCCATCTCGCTCA
GGAGCTCCTCCACAACCGCCGGCAACACTACGGCCATCGCGCCGCAGGACACGCCCTCCACGACCGGCGGACCGCCGCGACGCTCCAGCT
GACTGCGCCTACCTGTGGAGGATCCTGACCCCCCGCCGGGGCAGGGCGAGACGGAGTGACGTCGGGGCGCGTCATCGCGCGTGCGGACGC
AGGGATGTCCTGCTCAGTCGTCAGGGCCCGGCCAATCCGGAGGGCGCTCGGCGCGTGGTCGGGGGCCAGGAGCGCGTCTGGCCTGCAGTG
CGCAGAGGACGCGGCGGGAGCATGTTCCGGCTCCTGAGCTGGAGCCTGGGCCGAGGCTTCCTGCGGGCCGCGGGGCGGCGGTGCCGGGGC
TGCTCCGCGCGCCTGCTCCCGGGGCTGGCAGGAGGTCCGGGGCCCGAGGTGCAGGTGCCGCCATCCCGAGTCGCGCCGCACGGCCGGGGC
CCAGGCCTGCTGCCGCTGCTGGCAGCGCTCGCCTGGTTCTCGAGGCCCGCTGCGGCAGAGGAGGAGGAGCAGCAGGGAGCCGACGGGGCC
GCTGCCGAGGACGGGGCGGACGAGGCCGAGGCAGAGATCATCCAGCTGCTGAAGCGAGCCAAGTTGAGCATTATGAAAGATGAGCCAGAA
GAGGCTGAGTTAATTTTGCATGACGCTCTTCGTCTCGCCTATCAGACTGATAACAAGAAGGCCATCACTTACACTTATGATTTGATGGCC
AACTTAGCATTTATACGGGGTCAGCTTGAAAATGCTGAACAACTTTTTAAAGCAACAATGAGTTACCTCCTTGGAGGGGGCATGAAGCAG
GAGGACAATGCAATAATTGAAATTTCCCTAAAGCTGGCCAGTATCTATGCTGCGCAGAACAGACAGGAATTTGCTGTTGCTGGCTATGAA
TTCTGCATTTCAACTCTAGAGGAAAAAATTGAAAGAGAAAAGGAATTAGCAGAAGACATTATGTCAGGAAATTACTACAATCAAGGAGAG
ACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGAT
GACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGAAAGACAGAGCA
AATTCCAGATTGTGAGCAGCCACCTGCATCCTCTATGCCTGAGCGGCCCAGCCATGAGAGCCAGCCGACCCCACAGATGATGCCCCTTTC

>94924_94924_8_TTC19-PIGL_TTC19_chr17_15909882_ENST00000486880_PIGL_chr17_16137285_ENST00000581006_length(amino acids)=418AA_BP=0
MAQPHTTSVPYFARSPAPPPPSRSGAPPQPPATLRPSRRRTRPPRPADRRDAPADCAYLWRILTPRRGRARRSDVGARHRACGRRDVLLS
RQGPANPEGARRVVGGQERVWPAVRRGRGGSMFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPL
LAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIR
GQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSGNYYNQGETRKKEL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TTC19-PIGL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTC19-PIGL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTC19-PIGL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource