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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TTC28-EIF4ENIF1 (FusionGDB2 ID:94975)

Fusion Gene Summary for TTC28-EIF4ENIF1

Fusion gene summary

Fusion gene information	Fusion gene name: TTC28-EIF4ENIF1
	Fusion gene ID: 94975
		Hgene	Tgene
	Gene symbol	TTC28	EIF4ENIF1
	Gene ID	23331	56478
	Gene name	tetratricopeptide repeat domain 28	eukaryotic translation initiation factor 4E nuclear import factor 1
	Synonyms	TPRBK	4E-T\|Clast4
	Cytomap	22q12.1	22q12.2
	Type of gene	protein-coding	protein-coding
	Description	tetratricopeptide repeat protein 28TPR repeat protein 28TPR repeat-containing big gene cloned at KeioTPR-containing big gene cloned at Keio	eukaryotic translation initiation factor 4E transporter2610509L04Rik4E-transportereIF4E transporter
	Modification date	20200313	20200327
	UniProtAcc	.	Q9NRA8
	Ensembl transtripts involved in fusion gene	ENST00000397906, ENST00000490475,	ENST00000382180, ENST00000441289, ENST00000330125, ENST00000344710, ENST00000397523, ENST00000397525,
Fusion gene scores	* DoF score	46 X 33 X 13=19734	10 X 7 X 9=630
	# samples	53	11
	** MAII score	log2(53/19734*10)=-5.218547244106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TTC28 [Title/Abstract] AND EIF4ENIF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TTC28(29025540)-EIF4ENIF1(31867903), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TTC28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EIF4ENIF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-61-2000-01A	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-

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Fusion Gene ORF analysis for TTC28-EIF4ENIF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000397906	ENST00000382180	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
5CDS-intron	ENST00000397906	ENST00000441289	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
In-frame	ENST00000397906	ENST00000330125	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
In-frame	ENST00000397906	ENST00000344710	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
In-frame	ENST00000397906	ENST00000397523	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
In-frame	ENST00000397906	ENST00000397525	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
intron-3CDS	ENST00000490475	ENST00000330125	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
intron-3CDS	ENST00000490475	ENST00000344710	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
intron-3CDS	ENST00000490475	ENST00000397523	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
intron-3CDS	ENST00000490475	ENST00000397525	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
intron-intron	ENST00000490475	ENST00000382180	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-
intron-intron	ENST00000490475	ENST00000441289	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000397906	TTC28	chr22	29025540	-	ENST00000344710	EIF4ENIF1	chr22	31867903	-	3380	523	94	2862	922
ENST00000397906	TTC28	chr22	29025540	-	ENST00000397525	EIF4ENIF1	chr22	31867903	-	3898	523	94	3384	1096
ENST00000397906	TTC28	chr22	29025540	-	ENST00000330125	EIF4ENIF1	chr22	31867903	-	3896	523	94	3384	1096
ENST00000397906	TTC28	chr22	29025540	-	ENST00000397523	EIF4ENIF1	chr22	31867903	-	3820	523	94	3312	1072

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000397906	ENST00000344710	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-	0.001476865	0.9985232
ENST00000397906	ENST00000397525	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-	0.000562268	0.99943775
ENST00000397906	ENST00000330125	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-	0.000554257	0.99944574
ENST00000397906	ENST00000397523	TTC28	chr22	29025540	-	EIF4ENIF1	chr22	31867903	-	0.001114173	0.9988858

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Fusion Genomic Features for TTC28-EIF4ENIF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTC28-EIF4ENIF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29025540/chr22:31867903)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	EIF4ENIF1 Q9NRA8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250\|UniProtKB:Q9EST3, ECO:0000269\|PubMed:10856257, ECO:0000269\|PubMed:16157702, ECO:0000269\|PubMed:22966201, ECO:0000269\|PubMed:24335285, ECO:0000269\|PubMed:27342281, ECO:0000269\|PubMed:28216671, ECO:0000269\|PubMed:28487484, ECO:0000269\|PubMed:32354837}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

58_91

127

2482.0

Repeat

Note=TPR 1

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

93_125

127

2482.0

Repeat

Note=TPR 2

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000330125

148_210

986.0

Compositional bias

Note=Arg-rich

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000344710

148_210

812.0

Compositional bias

Note=Arg-rich

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000397525

148_210

986.0

Compositional bias

Note=Arg-rich

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000330125

195_211

986.0

Motif

Nuclear localization signal

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000330125

438_447

986.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000330125

613_638

986.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000344710

195_211

812.0

Motif

Nuclear localization signal

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000344710

438_447

812.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000344710

613_638

812.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000397525

195_211

986.0

Motif

Nuclear localization signal

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000397525

438_447

986.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000397525

613_638

986.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000330125

664_693

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000330125

707_803

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000330125

922_953

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000344710

664_693

812.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000344710

707_803

812.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000344710

922_953

812.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000397525

664_693

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000397525

707_803

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000397525

922_953

986.0

Region

Disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

1948_2006

127

2482.0

Compositional bias

Note=Ser-rich

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

2201_2335

127

2482.0

Compositional bias

Note=Ser-rich

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

1037_1070

127

2482.0

Repeat

Note=TPR 25

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

1077_1110

127

2482.0

Repeat

Note=TPR 26

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

1117_1150

127

2482.0

Repeat

Note=TPR 27

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

1169_1202

127

2482.0

Repeat

Note=TPR 28

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

126_159

127

2482.0

Repeat

Note=TPR 3

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

196_229

127

2482.0

Repeat

Note=TPR 4

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

234_267

127

2482.0

Repeat

Note=TPR 5

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

274_307

127

2482.0

Repeat

Note=TPR 6

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

314_347

127

2482.0

Repeat

Note=TPR 7

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

354_387

127

2482.0

Repeat

Note=TPR 8

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

394_427

127

2482.0

Repeat

Note=TPR 9

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

434_467

127

2482.0

Repeat

Note=TPR 10

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

474_507

127

2482.0

Repeat

Note=TPR 11

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

514_547

127

2482.0

Repeat

Note=TPR 12

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

554_587

127

2482.0

Repeat

Note=TPR 13

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

594_627

127

2482.0

Repeat

Note=TPR 14

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

634_667

127

2482.0

Repeat

Note=TPR 15

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

674_707

127

2482.0

Repeat

Note=TPR 16

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

714_747

127

2482.0

Repeat

Note=TPR 17

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

754_787

127

2482.0

Repeat

Note=TPR 18

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

794_827

127

2482.0

Repeat

Note=TPR 19

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

834_867

127

2482.0

Repeat

Note=TPR 20

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

877_910

127

2482.0

Repeat

Note=TPR 21

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

917_950

127

2482.0

Repeat

Note=TPR 22

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

957_990

127

2482.0

Repeat

Note=TPR 23

Hgene

TTC28

chr22:29025540

chr22:31867903

ENST00000397906

997_1030

127

2482.0

Repeat

Note=TPR 24

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000330125

1_24

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000344710

1_24

812.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:29025540

chr22:31867903

ENST00000397525

1_24

986.0

Region

Disordered

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Fusion Gene Sequence for TTC28-EIF4ENIF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>94975_94975_1_TTC28-EIF4ENIF1_TTC28_chr22_29025540_ENST00000397906_EIF4ENIF1_chr22_31867903_ENST00000330125_length(transcript)=3896nt_BP=523nt
GGGGGCGCGCGCGCGGTTTGGGGGCAGTGAGGGGCGCCGCGGCGGCGCGCAGCACGGCGGGAACATGGCGCGCGGAACCGGCGCGCGCGC
CTAGCTGGCGGGACCGTTAGCTCGAGGCGGACGCGGCCCGGGCCCCGTGGGGATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCA
AGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCGGCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTAT
TGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAGAAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGA
TTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAGAACTGCATCTTATACAGCAATAGATCTGCAGCCTACAT
GAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTTCTCAATCCCAAGTGGCCAAAGGAAGAACTCTTGGATAT
AAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGTGATGGTGTCTGGGACCCTGAGAAGTGGCATGC
CTCTCTCTACCCAGCTTCAGGGCGGAGCTCACCAGTGGAAAGTCTGAAGAAAGAGTTGGATACAGACCGGCCTTCCCTGGTGCGCAGGAT
AGTAGATCCACGAGAGCGTGTGAAAGAAGATGACTTAGATGTTGTTCTCAGCCCTCAGAGACGGAGCTTTGGAGGGGGCTGCCACGTGAC
AGCCGCTGTTAGCTCCCGGCGCTCAGGAAGTCCATTAGAGAAAGATAGTGATGGGCTTCGTCTGCTTGGTGGACGTAGGATTGGCAGTGG
GAGGATAATCTCTGCCCGGACCTTTGAGAAGGATCACCGTCTTAGCGATAAGGACCTGCGGGACTTGAGAGACAGAGACCGAGAGAGGGA
CTTCAAGGACAAGCGTTTCAGGAGAGAGTTTGGAGATAGTAAGCGTGTCTTTGGTGAGCGTAGAAGAAATGATTCTTACACAGAAGAAGA
ACCAGAGTGGTTCTCTGCTGGACCCACAAGTCAGTCTGAAACCATCGAACTGACTGGCTTTGATGATAAGATACTAGAAGAAGATCACAA
AGGGAGAAAAAGAACAAGGCGACGGACAGCCTCTGTGAAGGAAGGTATAGTAGAGTGCAATGGAGGAGTGGCCGAAGAGGATGAAGTGGA
GGTCATCCTTGCACAGGAGCCTGCGGCTGATCAGGAAGTGCCAAGGGATGCTGTCTTGCCTGAGCAGTCCCCAGGAGACTTTGACTTTAA
TGAGTTCTTTAACCTTGATAAGGTGCCATGCTTGGCTTCGATGATAGAAGATGTTTTGGGAGAAGGGTCAGTCTCTGCCAGTCGGTTCAG
TAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCAGCAGTCTTGGGTCAACACCACATGAAGAGCTAGAGAGACTTGCAGGTCT
GGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATTACTTTGCTCCTATACCATTGGAAGACCATGCTGAAAATAAAGTGGATAT
TTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTCTTCTTTCCAGCCTTTCTGCAAATAAAGAAAAACTTAAAGAAAGCTCACA
TTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTCTGAAGGGCTTGAAGGTTGACCAGCAAGTGAAGAATTCAACTCCCTTCAT
GGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACAATCGACAACTGAAGAAAGACGGAGACATGACTGCGTTCAACAAGCTAGT
GAGCACAATGAAGGCAAGTGGGACTTTGCCTTCTCAGCCCAAAGTCAGCCGAAACCTTGAAAGCCATTTGATGTCCCCTGCTGAGATTCC
AGGCCAGCCTGTCCCTAAGAACATCCTGCAGGAACTTCTGGGTCAACCAGTTCAGAGACCTGCTTCTTCCAATCTTCTGAGTGGCCTTAT
GGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTCACAGGTGTTTCAAACTCGAGCAGCCTCAGC
TGACTACCTTCGCCCAAGAATACCATCACCAATTGGTTTCACACCAGGACCACAGCAGCTACTCGGAGATCCATTCCAAGGCATGCGCAA
ACCCATGAGCCCCATCACAGCCCAGATGAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGAAGGGCTGGCCTTGCCACATGACCTTGCTGT
ACAGGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCACAGGTGGACAGAACCAGAGATGGATTCAGAAACAGGCAACAGCGAGTGAC
CAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCCTGCCCCTGCTGCCTCCATCACAAGCATGCTTTCTCCTTCCTTTACCCC
TACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATCTGGAAAAGCAGCTCTTGGTGACAGTAAAGA
GGATACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCAGCTCTGTACCCAGTGCCGATCGAGACTCTTCTCCCACTACAAATTCCAA
ACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGTCCCAGGCCAACCGTTACACCAAAGAACAAGATTATCGACCTAAAGCAAC
TGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAACACCTTTTCTCCGCCCTGTCCACCAAGTTCCCCTTGTCCCCCATGTCCC
TATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTACAGAGGATGCTGGCCCAGGGAGTACATCCACAGCATCTTCCAAGTTTGCT
CCAAACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATTTACAGGGAATATCTGGCCCCATCCTGGGTCAGCCCTTTTACCCTTTACC
TGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGTGCAACAGCAGCTACAGCGCTCAGTTCTGCA
TCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGTGCCCAGCCGGTCAGGCCTGCCCCACATGCA
CTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATGGTTTGGCTCAGATGTGCTACAGCAACCCCT
GCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGGGCAGGCAGACTCAACTAAGCCCGGACCTGT
GGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGGAGCACTCTGTGTGAAGCTGTTTGGTGGAAC
CCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGTACATTGTCTGAATACAGGATGCACAATGTT
GTCAATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTGAATGAAGTGTTGGTGTCCTCACCAAGAGGTGGCACCTAAGGGTTCTGAG
GAAATAAATGTATAGACCCTTATGTACAGACCTGTGTATAAACAACTTTTGTATATACATATAGGATAGCTTTTTTGAACTATACAGCTG
TACATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAGTTTGGATTTTTTTCACTTGTACATTTGGGATTTTCTTTTGGTTGATTAA

>94975_94975_1_TTC28-EIF4ENIF1_TTC28_chr22_29025540_ENST00000397906_EIF4ENIF1_chr22_31867903_ENST00000330125_length(amino acids)=1096AA_BP=143
MAGPLARGGRGPGPVGMEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDF
HTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKEELLDIKELPHSKQRPSCLSEKYDSDGVWDPEKWHAS
LYPASGRSSPVESLKKELDTDRPSLVRRIVDPRERVKEDDLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGR
IISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKG
RKRTRRRTASVKEGIVECNGGVAEEDEVEVILAQEPAADQEVPRDAVLPEQSPGDFDFNEFFNLDKVPCLASMIEDVLGEGSVSASRFSR
WFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHS
GVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLESHLMSPAEIPG
QPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKP
MSPITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPT
SVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATG
RKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPA
ASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKWFGSDVLQQPLP

--------------------------------------------------------------
>94975_94975_2_TTC28-EIF4ENIF1_TTC28_chr22_29025540_ENST00000397906_EIF4ENIF1_chr22_31867903_ENST00000344710_length(transcript)=3380nt_BP=523nt
GGGGGCGCGCGCGCGGTTTGGGGGCAGTGAGGGGCGCCGCGGCGGCGCGCAGCACGGCGGGAACATGGCGCGCGGAACCGGCGCGCGCGC
CTAGCTGGCGGGACCGTTAGCTCGAGGCGGACGCGGCCCGGGCCCCGTGGGGATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCA
AGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCGGCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTAT
TGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAGAAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGA
TTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAGAACTGCATCTTATACAGCAATAGATCTGCAGCCTACAT
GAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTTCTCAATCCCAAGTGGCCAAAGGAAGAACTCTTGGATAT
AAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGTGATGGTGTCTGGGACCCTGAGAAGTGGCATGC
CTCTCTCTACCCAGCTTCAGGGCGGAGCTCACCAGTGGAAAGTCTGAAGAAAGAGTTGGATACAGACCGGCCTTCCCTGGTGCGCAGGAT
AGTAGGTATAGTAGAGTGCAATGGAGGAGTGGCCGAAGAGGATGAAGTGGAGGTCATCCTTGCACAGGAGCCTGCGGCTGATCAGGAAGT
GCCAAGGGATGCTGTCTTGCCTGAGCAGTCCCCAGGAGACTTTGACTTTAATGAGTTCTTTAACCTTGATAAGGTGCCATGCTTGGCTTC
GATGATAGAAGATGTTTTGGGAGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATC
CAGCAGTCTTGGGTCAACACCACATGAAGAGCTAGAGAGACTTGCAGGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAA
TTACTTTGCTCCTATACCATTGGAAGACCATGCTGAAAATAAAGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACC
TCTTCTTTCCAGCCTTTCTGCAAATAAAGAAAAACTTAAAGAAAGCTCACATTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGG
TCTGAAGGGCTTGAAGGTTGACCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAA
CAATCGACAACTGAAGAAAGACGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGCGAAACCTTGAAAGCCATTTGATGTC
CCCTGCTGAGATTCCAGGCCAGCCTGTCCCTAAGAACATCCTGCAGGAACTTCTGGGTCAACCAGTTCAGAGACCTGCTTCTTCCAATCT
TCTGAGTGGCCTTATGGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTCACAGGTGTTTCAAAC
TCGAGCAGCCTCAGCTGACTACCTTCGCCCAAGAATACCATCACCAATTGGTTTCACACCAGGACCACAGCAGCTACTCGGAGATCCATT
CCAAGGCATGCGCAAACCCATGAGCCCCATCACAGCCCAGCAGATGAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGAAGGGCTGGCCTT
GCCACATGACCTTGCTGTACAGGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCACAGGTGGACAGAACCAGAGATGGATTCAGAAA
CAGGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCCTGCCCCTGCTGCCTCCATCACAAGCATGCT
TTCTCCTTCCTTTACCCCTACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATCTGGAAAAGCAGC
TCTTGGTGACAGTAAAGAGGATACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCAGCTCTGTACCCAGTGCCGATCGAGACTCTTC
TCCCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGTCCCAGGCCAACCGTTACACCAAAGAACAAGA
TTATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAACACCTTTTCTCCGCCCTGTCCACCAAGTTCC
CCTTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTACAGAGGATGCTGGCCCAGGGAGTACATCCACA
GCATCTTCCAAGTTTGCTCCAAACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATTTACAGGGAATATCTGGCCCCATCCTGGGTCA
GCCCTTTTACCCTTTACCTGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGTGCAACAGCAGCT
ACAGCGCTCAGTTCTGCATCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGTGCCCAGCCGGTC
AGGCCTGCCCCACATGCACTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATGGTTTGGCTCAGA
TGTGCTACAGCAACCCCTGCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGGGCAGGCAGACTC
AACTAAGCCCGGACCTGTGGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGGAGCACTCTGTGT
GAAGCTGTTTGGTGGAACCCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGTACATTGTCTGAA
TACAGGATGCACAATGTTGTCAATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTGAATGAAGTGTTGGTGTCCTCACCAAGAGGTG
GCACCTAAGGGTTCTGAGGAAATAAATGTATAGACCCTTATGTACAGACCTGTGTATAAACAACTTTTGTATATACATATAGGATAGCTT
TTTTGAACTATACAGCTGTACATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAGTTTGGATTTTTTTCACTTGTACATTTGGGAT

>94975_94975_2_TTC28-EIF4ENIF1_TTC28_chr22_29025540_ENST00000397906_EIF4ENIF1_chr22_31867903_ENST00000344710_length(amino acids)=922AA_BP=143
MAGPLARGGRGPGPVGMEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDF
HTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKEELLDIKELPHSKQRPSCLSEKYDSDGVWDPEKWHAS
LYPASGRSSPVESLKKELDTDRPSLVRRIVGIVECNGGVAEEDEVEVILAQEPAADQEVPRDAVLPEQSPGDFDFNEFFNLDKVPCLASM
IEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPL
LSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKRNLESHLMSP
AEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQ
GMRKPMSPITAQQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLS
PSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDY
RPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQP
FYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKWFGSDV

--------------------------------------------------------------
>94975_94975_3_TTC28-EIF4ENIF1_TTC28_chr22_29025540_ENST00000397906_EIF4ENIF1_chr22_31867903_ENST00000397523_length(transcript)=3820nt_BP=523nt
GGGGGCGCGCGCGCGGTTTGGGGGCAGTGAGGGGCGCCGCGGCGGCGCGCAGCACGGCGGGAACATGGCGCGCGGAACCGGCGCGCGCGC
CTAGCTGGCGGGACCGTTAGCTCGAGGCGGACGCGGCCCGGGCCCCGTGGGGATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCA
AGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCGGCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTAT
TGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAGAAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGA
TTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAGAACTGCATCTTATACAGCAATAGATCTGCAGCCTACAT
GAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTTCTCAATCCCAAGTGGCCAAAGGAAGAACTCTTGGATAT
AAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGTGATGGTGTCTGGGACCCTGAGAAGTGGCATGC
CTCTCTCTACCCAGCTTCAGGGCGGAGCTCACCAGTGGAAAGTCTGAAGAAAGAGTTGGATACAGACCGGCCTTCCCTGGTGCGCAGGAT
AGTAGATCCACGAGAGCGTGTGAAAGAAGATGACTTAGATGTTGTTCTCAGCCCTCAGAGACGGAGCTTTGGAGGGGGCTGCCACGTGAC
AGCCGCTGTTAGCTCCCGGCGCTCAGGAAGTCCATTAGAGAAAGATAGTGATGGGCTTCGTCTGCTTGGTGGACGTAGGATTGGCAGTGG
GAGGATAATCTCTGCCCGGACCTTTGAGAAGGATCACCGTCTTAGCGATAAGGACCTGCGGGACTTGAGAGACAGAGACCGAGAGAGGGA
CTTCAAGGACAAGCGTTTCAGGAGAGAGTTTGGAGATAGTAAGCGTGTCTTTGGTGAGCGTAGAAGAAATGATTCTTACACAGAAGAAGA
ACCAGAGTGGTTCTCTGCTGGACCCACAAGTCAGTCTGAAACCATCGAACTGACTGGCTTTGATGATAAGATACTAGAAGAAGATCACAA
AGGGAGAAAAAGAACAAGGCGACGGACAGCCTCTGTGAAGGAAGGTATAGTAGAGTGCAATGGAGGAGTGGCCGAAGAGGATGAAGTGGA
GGTCATCCTTGCACAGGAGCCTGCGGCTGATCAGGAAGTGCCAAGGGATGCTGTCTTGCCTGAGCAGTCCCCAGGAGACTTTGACTTTAA
TGAGTTCTTTAACCTTGATAAGGTGCCATGCTTGGCTTCGATGATAGAAGATGTTTTGGGAGAAGGGTCAGTCTCTGCCAGTCGGTTCAG
TAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCAGCAGTCTTGGGTCAACACCACATGAAGAGCTAGAGAGACTTGCAGGTCT
GGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATTACTTTGCTCCTATACCATTGGAAGACCATGCTGAAAATAAAGTGGATAT
TTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTCTTCTTTCCAGCCTTTCTGCAAATAAAGAAAAACTTAAAGAAAGCTCACA
TTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTCTGAAGGGCTTGAAGGTTGACCAGCAAGTGAAGAATTCAACTCCCTTCAT
GGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACAATCGACAACTGAAGAAAGACGGAGACATGACTGCGTTCAACAAGCTAGT
GAGCACAATGAAGGCAAGTGGGACTTTGCCTTCTCAGCCCAAAGTCAGCGAACTTCTGGGTCAACCAGTTCAGAGACCTGCTTCTTCCAA
TCTTCTGAGTGGCCTTATGGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTCACAGGTGTTTCA
AACTCGAGCAGCCTCAGCTGACTACCTTCGCCCAAGAATACCATCACCAATTGGTTTCACACCAGGACCACAGCAGCTACTCGGAGATCC
ATTCCAAGGCATGCGCAAACCCATGAGCCCCATCACAGCCCAGATGAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGAAGGGCTGGCCTT
GCCACATGACCTTGCTGTACAGGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCACAGGTGGACAGAACCAGAGATGGATTCAGAAA
CAGGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCCTGCCCCTGCTGCCTCCATCACAAGCATGCT
TTCTCCTTCCTTTACCCCTACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATCTGGAAAAGCAGC
TCTTGGTGACAGTAAAGAGGATACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCAGCTCTGTACCCAGTGCCGATCGAGACTCTTC
TCCCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGTCCCAGGCCAACCGTTACACCAAAGAACAAGA
TTATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAACACCTTTTCTCCGCCCTGTCCACCAAGTTCC
CCTTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTACAGAGGATGCTGGCCCAGGGAGTACATCCACA
GCATCTTCCAAGTTTGCTCCAAACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATTTACAGGGAATATCTGGCCCCATCCTGGGTCA
GCCCTTTTACCCTTTACCTGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGTGCAACAGCAGCT
ACAGCGCTCAGTTCTGCATCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGTGCCCAGCCGGTC
AGGCCTGCCCCACATGCACTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATGGTTTGGCTCAGA
TGTGCTACAGCAACCCCTGCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGGGCAGGCAGACTC
AACTAAGCCCGGACCTGTGGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGGAGCACTCTGTGT
GAAGCTGTTTGGTGGAACCCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGTACATTGTCTGAA
TACAGGATGCACAATGTTGTCAATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTGAATGAAGTGTTGGTGTCCTCACCAAGAGGTG
GCACCTAAGGGTTCTGAGGAAATAAATGTATAGACCCTTATGTACAGACCTGTGTATAAACAACTTTTGTATATACATATAGGATAGCTT
TTTTGAACTATACAGCTGTACATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAGTTTGGATTTTTTTCACTTGTACATTTGGGAT

>94975_94975_3_TTC28-EIF4ENIF1_TTC28_chr22_29025540_ENST00000397906_EIF4ENIF1_chr22_31867903_ENST00000397523_length(amino acids)=1072AA_BP=143
MAGPLARGGRGPGPVGMEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDF
HTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKEELLDIKELPHSKQRPSCLSEKYDSDGVWDPEKWHAS
LYPASGRSSPVESLKKELDTDRPSLVRRIVDPRERVKEDDLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGR
IISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKG
RKRTRRRTASVKEGIVECNGGVAEEDEVEVILAQEPAADQEVPRDAVLPEQSPGDFDFNEFFNLDKVPCLASMIEDVLGEGSVSASRFSR
WFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHS
GVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSELLGQPVQRPASSNL
LSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEGLALP
HDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAAL
GDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPL
VPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQ

--------------------------------------------------------------
>94975_94975_4_TTC28-EIF4ENIF1_TTC28_chr22_29025540_ENST00000397906_EIF4ENIF1_chr22_31867903_ENST00000397525_length(transcript)=3898nt_BP=523nt
GGGGGCGCGCGCGCGGTTTGGGGGCAGTGAGGGGCGCCGCGGCGGCGCGCAGCACGGCGGGAACATGGCGCGCGGAACCGGCGCGCGCGC
CTAGCTGGCGGGACCGTTAGCTCGAGGCGGACGCGGCCCGGGCCCCGTGGGGATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCA
AGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCGGCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTAT
TGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAGAAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGA
TTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAGAACTGCATCTTATACAGCAATAGATCTGCAGCCTACAT
GAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTTCTCAATCCCAAGTGGCCAAAGGAAGAACTCTTGGATAT
AAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGTGATGGTGTCTGGGACCCTGAGAAGTGGCATGC
CTCTCTCTACCCAGCTTCAGGGCGGAGCTCACCAGTGGAAAGTCTGAAGAAAGAGTTGGATACAGACCGGCCTTCCCTGGTGCGCAGGAT
AGTAGATCCACGAGAGCGTGTGAAAGAAGATGACTTAGATGTTGTTCTCAGCCCTCAGAGACGGAGCTTTGGAGGGGGCTGCCACGTGAC
AGCCGCTGTTAGCTCCCGGCGCTCAGGAAGTCCATTAGAGAAAGATAGTGATGGGCTTCGTCTGCTTGGTGGACGTAGGATTGGCAGTGG
GAGGATAATCTCTGCCCGGACCTTTGAGAAGGATCACCGTCTTAGCGATAAGGACCTGCGGGACTTGAGAGACAGAGACCGAGAGAGGGA
CTTCAAGGACAAGCGTTTCAGGAGAGAGTTTGGAGATAGTAAGCGTGTCTTTGGTGAGCGTAGAAGAAATGATTCTTACACAGAAGAAGA
ACCAGAGTGGTTCTCTGCTGGACCCACAAGTCAGTCTGAAACCATCGAACTGACTGGCTTTGATGATAAGATACTAGAAGAAGATCACAA
AGGGAGAAAAAGAACAAGGCGACGGACAGCCTCTGTGAAGGAAGGTATAGTAGAGTGCAATGGAGGAGTGGCCGAAGAGGATGAAGTGGA
GGTCATCCTTGCACAGGAGCCTGCGGCTGATCAGGAAGTGCCAAGGGATGCTGTCTTGCCTGAGCAGTCCCCAGGAGACTTTGACTTTAA
TGAGTTCTTTAACCTTGATAAGGTGCCATGCTTGGCTTCGATGATAGAAGATGTTTTGGGAGAAGGGTCAGTCTCTGCCAGTCGGTTCAG
TAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCAGCAGTCTTGGGTCAACACCACATGAAGAGCTAGAGAGACTTGCAGGTCT
GGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATTACTTTGCTCCTATACCATTGGAAGACCATGCTGAAAATAAAGTGGATAT
TTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTCTTCTTTCCAGCCTTTCTGCAAATAAAGAAAAACTTAAAGAAAGCTCACA
TTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTCTGAAGGGCTTGAAGGTTGACCAGCAAGTGAAGAATTCAACTCCCTTCAT
GGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACAATCGACAACTGAAGAAAGACGGAGACATGACTGCGTTCAACAAGCTAGT
GAGCACAATGAAGGCAAGTGGGACTTTGCCTTCTCAGCCCAAAGTCAGCCGAAACCTTGAAAGCCATTTGATGTCCCCTGCTGAGATTCC
AGGCCAGCCTGTCCCTAAGAACATCCTGCAGGAACTTCTGGGTCAACCAGTTCAGAGACCTGCTTCTTCCAATCTTCTGAGTGGCCTTAT
GGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTCACAGGTGTTTCAAACTCGAGCAGCCTCAGC
TGACTACCTTCGCCCAAGAATACCATCACCAATTGGTTTCACACCAGGACCACAGCAGCTACTCGGAGATCCATTCCAAGGCATGCGCAA
ACCCATGAGCCCCATCACAGCCCAGATGAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGAAGGGCTGGCCTTGCCACATGACCTTGCTGT
ACAGGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCACAGGTGGACAGAACCAGAGATGGATTCAGAAACAGGCAACAGCGAGTGAC
CAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCCTGCCCCTGCTGCCTCCATCACAAGCATGCTTTCTCCTTCCTTTACCCC
TACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATCTGGAAAAGCAGCTCTTGGTGACAGTAAAGA
GGATACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCAGCTCTGTACCCAGTGCCGATCGAGACTCTTCTCCCACTACAAATTCCAA
ACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGTCCCAGGCCAACCGTTACACCAAAGAACAAGATTATCGACCTAAAGCAAC
TGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAACACCTTTTCTCCGCCCTGTCCACCAAGTTCCCCTTGTCCCCCATGTCCC
TATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTACAGAGGATGCTGGCCCAGGGAGTACATCCACAGCATCTTCCAAGTTTGCT
CCAAACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATTTACAGGGAATATCTGGCCCCATCCTGGGTCAGCCCTTTTACCCTTTACC
TGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGTGCAACAGCAGCTACAGCGCTCAGTTCTGCA
TCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGTGCCCAGCCGGTCAGGCCTGCCCCACATGCA
CTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATGGTTTGGCTCAGATGTGCTACAGCAACCCCT
GCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGGGCAGGCAGACTCAACTAAGCCCGGACCTGT
GGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGGAGCACTCTGTGTGAAGCTGTTTGGTGGAAC
CCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGTACATTGTCTGAATACAGGATGCACAATGTT
GTCAATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTGAATGAAGTGTTGGTGTCCTCACCAAGAGGTGGCACCTAAGGGTTCTGAG
GAAATAAATGTATAGACCCTTATGTACAGACCTGTGTATAAACAACTTTTGTATATACATATAGGATAGCTTTTTTGAACTATACAGCTG
TACATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAGTTTGGATTTTTTTCACTTGTACATTTGGGATTTTCTTTTGGTTGATTAA

>94975_94975_4_TTC28-EIF4ENIF1_TTC28_chr22_29025540_ENST00000397906_EIF4ENIF1_chr22_31867903_ENST00000397525_length(amino acids)=1096AA_BP=143
MAGPLARGGRGPGPVGMEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDF
HTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKEELLDIKELPHSKQRPSCLSEKYDSDGVWDPEKWHAS
LYPASGRSSPVESLKKELDTDRPSLVRRIVDPRERVKEDDLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGR
IISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKG
RKRTRRRTASVKEGIVECNGGVAEEDEVEVILAQEPAADQEVPRDAVLPEQSPGDFDFNEFFNLDKVPCLASMIEDVLGEGSVSASRFSR
WFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHS
GVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLESHLMSPAEIPG
QPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKP
MSPITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPT
SVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATG
RKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPA
ASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKWFGSDVLQQPLP

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Fusion Gene PPI Analysis for TTC28-EIF4ENIF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000330125		1	19	131_161	32.0	986.0	CSDE1
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000344710		1	17	131_161	32.0	812.0	CSDE1
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000397525		1	19	131_161	32.0	986.0	CSDE1
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000330125		1	19	219_240	32.0	986.0	DDX6
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000344710		1	17	219_240	32.0	812.0	DDX6
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000397525		1	19	219_240	32.0	986.0	DDX6
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000330125		1	19	448_490	32.0	986.0	LSM14A
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000330125		1	19	940_985	32.0	986.0	LSM14A
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000344710		1	17	448_490	32.0	812.0	LSM14A
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000344710		1	17	940_985	32.0	812.0	LSM14A
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000397525		1	19	448_490	32.0	986.0	LSM14A
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000397525		1	19	940_985	32.0	986.0	LSM14A
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000330125		1	19	695_713	32.0	986.0	PATL1
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000344710		1	17	695_713	32.0	812.0	PATL1
Tgene	EIF4ENIF1	chr22:29025540	chr22:31867903	ENST00000397525		1	19	695_713	32.0	986.0	PATL1

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TTC28-EIF4ENIF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TTC28-EIF4ENIF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source