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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTC39C-CABLES1 (FusionGDB2 ID:95041)

Fusion Gene Summary for TTC39C-CABLES1

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC39C-CABLES1
Fusion gene ID: 95041
HgeneTgene
Gene symbol

TTC39C

CABLES1

Gene ID

125488

91768

Gene nametetratricopeptide repeat domain 39CCdk5 and Abl enzyme substrate 1
SynonymsC18orf17|HsT2697CABL1|CABLES|HsT2563|IK3-1
Cytomap

18q11.2

18q11.2

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 39CTPR repeat protein 39CCDK5 and ABL1 enzyme substrate 1interactor with CDK3 1
Modification date2020031320200313
UniProtAcc.

Q8TDN4

Ensembl transtripts involved in fusion geneENST00000578150, ENST00000317571, 
ENST00000584250, ENST00000304621, 
ENST00000540918, ENST00000577185, 
ENST00000256925, ENST00000400473, 
ENST00000420687, ENST00000585061, 
Fusion gene scores* DoF score6 X 5 X 5=15013 X 10 X 5=650
# samples 614
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/650*10)=-2.21501289097085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTC39C [Title/Abstract] AND CABLES1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTC39C(21595002)-CABLES1(20837191), # samples:3
CABLES1(20794018)-TTC39C(21644104), # samples:1
Anticipated loss of major functional domain due to fusion event.TTC39C-CABLES1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TTC39C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CABLES1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0893-01BTTC39Cchr18

21595002

-CABLES1chr18

20837191

+
ChimerDB4OVTCGA-13-0893-01BTTC39Cchr18

21595002

+CABLES1chr18

20837191

+


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Fusion Gene ORF analysis for TTC39C-CABLES1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000578150ENST00000256925TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
3UTR-3CDSENST00000578150ENST00000400473TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
3UTR-intronENST00000578150ENST00000420687TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
3UTR-intronENST00000578150ENST00000585061TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
5CDS-intronENST00000317571ENST00000420687TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
5CDS-intronENST00000317571ENST00000585061TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
5CDS-intronENST00000584250ENST00000420687TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
5CDS-intronENST00000584250ENST00000585061TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
Frame-shiftENST00000317571ENST00000400473TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
Frame-shiftENST00000584250ENST00000400473TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
In-frameENST00000317571ENST00000256925TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
In-frameENST00000584250ENST00000256925TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-3CDSENST00000304621ENST00000256925TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-3CDSENST00000304621ENST00000400473TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-3CDSENST00000540918ENST00000256925TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-3CDSENST00000540918ENST00000400473TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-3CDSENST00000577185ENST00000256925TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-3CDSENST00000577185ENST00000400473TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-intronENST00000304621ENST00000420687TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-intronENST00000304621ENST00000585061TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-intronENST00000540918ENST00000420687TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-intronENST00000540918ENST00000585061TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-intronENST00000577185ENST00000420687TTC39Cchr18

21595002

+CABLES1chr18

20837191

+
intron-intronENST00000577185ENST00000585061TTC39Cchr18

21595002

+CABLES1chr18

20837191

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317571TTC39Cchr1821595002+ENST00000256925CABLES1chr1820837191+36444034021134
ENST00000584250TTC39Cchr1821595002+ENST00000256925CABLES1chr1820837191+38606196181206

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317571ENST00000256925TTC39Cchr1821595002+CABLES1chr1820837191+0.333527770.66647226
ENST00000584250ENST00000256925TTC39Cchr1821595002+CABLES1chr1820837191+0.354289560.64571047

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Fusion Genomic Features for TTC39C-CABLES1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TTC39Cchr1821595002+CABLES1chr1820837190+2.84E-081
TTC39Cchr1821595002+CABLES1chr1820837190+2.84E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TTC39C-CABLES1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:21595002/chr18:20837191)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CABLES1

Q8TDN4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000317571+11419_2555584.0Compositional biasNote=Poly-Ala
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000584250+1219_255577.0Compositional biasNote=Poly-Ala

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000304621+11419_250523.0Compositional biasNote=Poly-Ala
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000304621+114315_3480523.0RepeatNote=TPR 1
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000304621+114353_3860523.0RepeatNote=TPR 2
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000304621+114485_5180523.0RepeatNote=TPR 3
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000317571+114315_34855584.0RepeatNote=TPR 1
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000317571+114353_38655584.0RepeatNote=TPR 2
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000317571+114485_51855584.0RepeatNote=TPR 3
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000584250+12315_3485577.0RepeatNote=TPR 1
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000584250+12353_3865577.0RepeatNote=TPR 2
HgeneTTC39Cchr18:21595002chr18:20837191ENST00000584250+12485_5185577.0RepeatNote=TPR 3
TgeneCABLES1chr18:21595002chr18:20837191ENST000002569258102_134587634.0Compositional biasNote=Ala-rich
TgeneCABLES1chr18:21595002chr18:20837191ENST000004004738102_134260307.0Compositional biasNote=Ala-rich
TgeneCABLES1chr18:21595002chr18:20837191ENST000004206878102_134322369.0Compositional biasNote=Ala-rich


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Fusion Gene Sequence for TTC39C-CABLES1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95041_95041_1_TTC39C-CABLES1_TTC39C_chr18_21595002_ENST00000317571_CABLES1_chr18_20837191_ENST00000256925_length(transcript)=3644nt_BP=403nt
TGAGTAATCCCCGCGGCGGCGGCCGGACGCCCACCTCCCACGCCGCGCCGCAGCCGGGCCGCGGCTCCTCCCTCCGCGGTCCTTCCCTCC
TCTTCCCTCCCGTCTTCTCCCCTCCCCTCCCCTCCCCTCCCGGCTCCGCTTGGCTCCGGGCAGGTAGAGCCGGGCTCCGGGCGCGCGCGG
GGCCGCAGCAGCTGCTCCCGATCTCGCCTCGGCCCAGCGCAGGGCCTCGCACGCCCATGGCCGGCTCGGAGCAGCAGCGGCCGCGGCGGC
GGGACGACGGAGACTCGGACGCGGCAGCGGCGGCGGCGGCGCCCCTGCAGGACGCGGAGCTGGCCCTGGCCGGCATCAACATGCTGCTCA
ACAACGGCTTCAGGGAGTCGGACCAGCTTTTCAAACAATACAGAAACTGGAAGAGAAGTTCCGGCTGAACAGGCGAGAACTGATTGCCTT
TGAATTCCCGGTGTTAGTGGCCTTGGAATTCGCCCTCCACTTGCCCGAGCACGAAGTCATGCCCCACTACAGACGGCTGGTCCAGAGTTC
CTAGCACTGGCCCCGAGGACAGCCAAGGGCCATTTCTTCTCAGCTTGGTGGAGCAGCACTTACTTACTACTGGAAATGAAAAAAAGTAGA
ACTCAGAATACCAGACTTTTCTTCCTCTCGACATAGTTTGGGGAGAAGCAGTACTAGAAACTTTCCAAGGAGTCTTGGGTGTGTAGCCAA
GAGGAGCCATGAGCTATGGACTCCTCAAGCACGGGAAGAGGAGGTGTGTGCTGAGAACAGAGAGGCCCTGCCCTCTGTCCACTAGCGAGA
ATCCCTAGCTGCCCCAGCCCAGTCTTTCTCCCCGGCATTCACAAACTTTGCAAGCGTGGTCCAGGGCCTTCTCCAGATCTGTTCCAACTT
GGAGTGTGAAGGGCTTGAGCATACGGGGGAAGAGAGTCTGCAGAAGTTGGGGGAAAACTTTTAAAAGATACCCTCATTGTGTCAAAGAGT
GTGCCAATCTATTTTTGTATCAGCATTGGAAGTGCACTTTCCCCTGGGGCGTGTGGGTGTGTGAATGTGCAAGTGTCTGAGAGATACTGC
ATCAGCCCTAGACCCCCAGAGCCAGTCCCGCCCTTTACAGAGCAGCCCTTAGCCTGGGGCCATGGGTCAGGCTGACCTTCAACAATTATT
TCTAGATGATTTCTGGATAAGAATTGCTCTCTCGGTACCAGACAGTTTGACATCCTCCACCCTTAGAAAATGACTGACATTGTTTTGTTA
CTGCTCCTACCCACCAAGGGGATAAAGAAGGCGAGTTCTGAGTGTTGGATGAGTCAGTCGCGTGGAAGGACGTGGAGCGTGGCGCTCTGT
AACTTCCTGCCGTCTGCCACCCCGCCACGTGTATTTAACCCTCGCACTTTCTCCACTGTGGAGATGGCTGGGGCGGCGCCCCACAGTGTG
TATTCCTGTCCTCTATGTTAGAGTGCATCAGAAGCACATTTACTGTGCTATCTATATCGCTATATAAAAGTGTTTTATAAAAACCCAGAA
TAGGAGCACGACGCATGATTGGTGTTTGAGGCGTTTGCCAGCTGGGACAAACTGCGTTTGGAGCTGTGGTTAAGCTGACTAAGGAGGCGG
TGGCTCTTTCTTAACATTCCCACGTGCCCAGGGCTGTTCATGCAAGATTTTAATGGTGACTTGTCCTGGCTTACTGGGACAGTCTGTATG
AGGCATGTCACCACACTGTCGCCTCATAGCTGCAAGAGAGAGGCACCAGCTGAAGTTCCCCTGACTGAAGAGAGCCTGTGGCCATGTAAA
AAGAGAATTAAACTCTTGTTGCTTTTTGTATACCTGTATGCGTTTGTGTAGACGTGTGTCTCACCAGTCACCTTTGCCCTGCATTGCTGA
TCCCCTTGCGCACACTGATTCTAGTGAGGTCACAGATTCGGAGCTTCACACACCAGCCCAGAGAAAGGGCGATGGAACCGAACCGAGGGT
CTGCAGCTTTCGTTAGCAGAGCTGTCAGATTCTTGACAGTCTTGGAGGATGGAGAAATTCAAGCAGCAGCTGGTGAGGGCCAAAACAGAA
TACTTGGCTTCTTCAGAATCTTAGATTGCACTGAGTTTAGTCCTAAATATTTTGCTAACAAATTTCCTTGGCCAGAATCAGTTGTAAGAC
AGTGATTTGGGTGGTGGGGGGAGGGAGGAGGGAGAGGATATGATTAATGTGGTCTCTTTGGCTGATCGAAAGCTAGATCAACTGGTACTT
AGGGCACTTGCTGTTTATAAAGCAAAATTGAGAAAATATTCAAGGTGCCTCCATCGCCTGAACTACAAAATGCCCTTGGCCTTCCTCACA
TGGGGTCTGTCACCTTGCATCTCTGATAAGCCATCCACCTTCCTGGTCAGTGCCTACAGGGGGAGAGCCTTTCTGAGAAGCAGGTCCTGT
GGTATCTGAGAATGGTCTAGAGAGCTCCCCACTGCCCATCTGCCCCCGAATTTCCTGCCAAGCTCTGGGGAGTGGGGTGGGGGGAGGGAC
GTCCGATGGATGACAGGCCGCCAGCCCAGACGTGGGGAGAGAAGCCTGAGTCCTTTCCTGTGTGATAAAATCAGGCTAATTTACTTGGAT
TTGGGGTGATTTGTTTGGTTTTTAGCATTTATGAGGTGAGCCCATGAAGTTAGTGGTCCATTACTTTTTAAAGATGCATTTTCATTTTAA
ACTGTCTCCTGGCCTGTGGATTTGTGGAATGGACAGTTTTGTGGGTTTTAATTTATTTGTGAGGAGTCGGGGCTGAGAAGGCATTTTATC
AGGAGGTCTCCTTTTGCACGTCCATGACATGAGCTTTTCGGAGGCAAAGGAAGTGGAGGAGGGTGAGAGATGCAGGTCACTGCCAGAGGC
ACCTCTGTGACACGGAACATTCCAGACACGTCGCAGCCTTGGGCTTCGGCGAGGAGGAAGTCTGAGCCTGTGAAGCGAGAAGGCCAGGCA
GTAGACTGGCTCTGAGGTTTTGCCCTTTGACCTCCTCCACAGAGGGCAGCTTCAGCCCCTTGTAAGCCCTGCCCCCTCTCAGGACTGCCC
TGAGGCCTCTCCAGTCCTCCCCACACTCAGAGATCTGTGGGGAAGCTCCGCCCAGCCACACTCCTTGGGATAATACTAGCCGGTTCTGCC
TGATTCCTTTTCCCCCGGAGCCAGCCTAGGGGGCCCGGGACTCCTCTAGTGAGCCTTGACTGTTAGGTAAGAGACAGGAAGCAGACAAGC
CAAGAGGTTGCTGCAGCTGCCCCCAGGAGGAAACGGGCAGCAGGGAGTGTGGCCCAGCCCCCACTGTACCCCTCCAGGGGCCCGAGCCCT
TGCCAGCCCAATGACACCTTGAAGTCACCACTTTTCCTTTCTTGCCCGCTAATAAAACCTATTTAAACAGGAAATTCATACCAAATGCAA
ATGGGTTTTGTTTTCCTTGGCATTTTGTTGTTCCGATCACAGATTTCCCTGCCAGGGTGTCTGTGGTTATCAGCTGCAGGCTCAGCTTGG
GGCGGCCGCTTCACACAAGCCACTCTGTACCACGTGCCCTACCTTAGTGACGGGAGTAAGGAGCTTCCTTCCCCTCCATGTCATTCCTTC

>95041_95041_1_TTC39C-CABLES1_TTC39C_chr18_21595002_ENST00000317571_CABLES1_chr18_20837191_ENST00000256925_length(amino acids)=134AA_BP=
MYCLKSWSDSLKPLLSSMLMPARASSASCRGAAAAAAASESPSSRRRGRCCSEPAMGVRGPALGRGEIGSSCCGPARARSPALPARSQAE

--------------------------------------------------------------
>95041_95041_2_TTC39C-CABLES1_TTC39C_chr18_21595002_ENST00000584250_CABLES1_chr18_20837191_ENST00000256925_length(transcript)=3860nt_BP=619nt
GTCTCGCGTGCGTGTGTCCGAGCAGTCCTGGGCGGTGGGCGAAGGCGCGGCTTGGGGACCCGGGAGGGGCCGGGGCGCGGGGGCTGCAGG
AAGTGGAGGCGGCCGCCGCTCGGGGACCGGCTTGGCGGGGTGAGAGACACCCGGAAACGGATTCCGCTTCGGGGCCCGCGCGAGTTGGGT
GCTTCGGAGGGCGCGAGAGGAGCGGGCGGGTGCTGCTGAGTAATCCCCGCGGCGGCGGCCGGACGCCCACCTCCCACGCCGCGCCGCAGC
CGGGCCGCGGCTCCTCCCTCCGCGGTCCTTCCCTCCTCTTCCCTCCCGTCTTCTCCCCTCCCCTCCCCTCCCCTCCCGGCTCCGCTTGGC
TCCGGGCAGGTAGAGCCGGGCTCCGGGCGCGCGCGGGGCCGCAGCAGCTGCTCCCGATCTCGCCTCGGCCCAGCGCAGGGCCTCGCACGC
CCATGGCCGGCTCGGAGCAGCAGCGGCCGCGGCGGCGGGACGACGGAGACTCGGACGCGGCAGCGGCGGCGGCGGCGCCCCTGCAGGACG
CGGAGCTGGCCCTGGCCGGCATCAACATGCTGCTCAACAACGGCTTCAGGGAGTCGGACCAGCTTTTCAAACAATACAGAAACTGGAAGA
GAAGTTCCGGCTGAACAGGCGAGAACTGATTGCCTTTGAATTCCCGGTGTTAGTGGCCTTGGAATTCGCCCTCCACTTGCCCGAGCACGA
AGTCATGCCCCACTACAGACGGCTGGTCCAGAGTTCCTAGCACTGGCCCCGAGGACAGCCAAGGGCCATTTCTTCTCAGCTTGGTGGAGC
AGCACTTACTTACTACTGGAAATGAAAAAAAGTAGAACTCAGAATACCAGACTTTTCTTCCTCTCGACATAGTTTGGGGAGAAGCAGTAC
TAGAAACTTTCCAAGGAGTCTTGGGTGTGTAGCCAAGAGGAGCCATGAGCTATGGACTCCTCAAGCACGGGAAGAGGAGGTGTGTGCTGA
GAACAGAGAGGCCCTGCCCTCTGTCCACTAGCGAGAATCCCTAGCTGCCCCAGCCCAGTCTTTCTCCCCGGCATTCACAAACTTTGCAAG
CGTGGTCCAGGGCCTTCTCCAGATCTGTTCCAACTTGGAGTGTGAAGGGCTTGAGCATACGGGGGAAGAGAGTCTGCAGAAGTTGGGGGA
AAACTTTTAAAAGATACCCTCATTGTGTCAAAGAGTGTGCCAATCTATTTTTGTATCAGCATTGGAAGTGCACTTTCCCCTGGGGCGTGT
GGGTGTGTGAATGTGCAAGTGTCTGAGAGATACTGCATCAGCCCTAGACCCCCAGAGCCAGTCCCGCCCTTTACAGAGCAGCCCTTAGCC
TGGGGCCATGGGTCAGGCTGACCTTCAACAATTATTTCTAGATGATTTCTGGATAAGAATTGCTCTCTCGGTACCAGACAGTTTGACATC
CTCCACCCTTAGAAAATGACTGACATTGTTTTGTTACTGCTCCTACCCACCAAGGGGATAAAGAAGGCGAGTTCTGAGTGTTGGATGAGT
CAGTCGCGTGGAAGGACGTGGAGCGTGGCGCTCTGTAACTTCCTGCCGTCTGCCACCCCGCCACGTGTATTTAACCCTCGCACTTTCTCC
ACTGTGGAGATGGCTGGGGCGGCGCCCCACAGTGTGTATTCCTGTCCTCTATGTTAGAGTGCATCAGAAGCACATTTACTGTGCTATCTA
TATCGCTATATAAAAGTGTTTTATAAAAACCCAGAATAGGAGCACGACGCATGATTGGTGTTTGAGGCGTTTGCCAGCTGGGACAAACTG
CGTTTGGAGCTGTGGTTAAGCTGACTAAGGAGGCGGTGGCTCTTTCTTAACATTCCCACGTGCCCAGGGCTGTTCATGCAAGATTTTAAT
GGTGACTTGTCCTGGCTTACTGGGACAGTCTGTATGAGGCATGTCACCACACTGTCGCCTCATAGCTGCAAGAGAGAGGCACCAGCTGAA
GTTCCCCTGACTGAAGAGAGCCTGTGGCCATGTAAAAAGAGAATTAAACTCTTGTTGCTTTTTGTATACCTGTATGCGTTTGTGTAGACG
TGTGTCTCACCAGTCACCTTTGCCCTGCATTGCTGATCCCCTTGCGCACACTGATTCTAGTGAGGTCACAGATTCGGAGCTTCACACACC
AGCCCAGAGAAAGGGCGATGGAACCGAACCGAGGGTCTGCAGCTTTCGTTAGCAGAGCTGTCAGATTCTTGACAGTCTTGGAGGATGGAG
AAATTCAAGCAGCAGCTGGTGAGGGCCAAAACAGAATACTTGGCTTCTTCAGAATCTTAGATTGCACTGAGTTTAGTCCTAAATATTTTG
CTAACAAATTTCCTTGGCCAGAATCAGTTGTAAGACAGTGATTTGGGTGGTGGGGGGAGGGAGGAGGGAGAGGATATGATTAATGTGGTC
TCTTTGGCTGATCGAAAGCTAGATCAACTGGTACTTAGGGCACTTGCTGTTTATAAAGCAAAATTGAGAAAATATTCAAGGTGCCTCCAT
CGCCTGAACTACAAAATGCCCTTGGCCTTCCTCACATGGGGTCTGTCACCTTGCATCTCTGATAAGCCATCCACCTTCCTGGTCAGTGCC
TACAGGGGGAGAGCCTTTCTGAGAAGCAGGTCCTGTGGTATCTGAGAATGGTCTAGAGAGCTCCCCACTGCCCATCTGCCCCCGAATTTC
CTGCCAAGCTCTGGGGAGTGGGGTGGGGGGAGGGACGTCCGATGGATGACAGGCCGCCAGCCCAGACGTGGGGAGAGAAGCCTGAGTCCT
TTCCTGTGTGATAAAATCAGGCTAATTTACTTGGATTTGGGGTGATTTGTTTGGTTTTTAGCATTTATGAGGTGAGCCCATGAAGTTAGT
GGTCCATTACTTTTTAAAGATGCATTTTCATTTTAAACTGTCTCCTGGCCTGTGGATTTGTGGAATGGACAGTTTTGTGGGTTTTAATTT
ATTTGTGAGGAGTCGGGGCTGAGAAGGCATTTTATCAGGAGGTCTCCTTTTGCACGTCCATGACATGAGCTTTTCGGAGGCAAAGGAAGT
GGAGGAGGGTGAGAGATGCAGGTCACTGCCAGAGGCACCTCTGTGACACGGAACATTCCAGACACGTCGCAGCCTTGGGCTTCGGCGAGG
AGGAAGTCTGAGCCTGTGAAGCGAGAAGGCCAGGCAGTAGACTGGCTCTGAGGTTTTGCCCTTTGACCTCCTCCACAGAGGGCAGCTTCA
GCCCCTTGTAAGCCCTGCCCCCTCTCAGGACTGCCCTGAGGCCTCTCCAGTCCTCCCCACACTCAGAGATCTGTGGGGAAGCTCCGCCCA
GCCACACTCCTTGGGATAATACTAGCCGGTTCTGCCTGATTCCTTTTCCCCCGGAGCCAGCCTAGGGGGCCCGGGACTCCTCTAGTGAGC
CTTGACTGTTAGGTAAGAGACAGGAAGCAGACAAGCCAAGAGGTTGCTGCAGCTGCCCCCAGGAGGAAACGGGCAGCAGGGAGTGTGGCC
CAGCCCCCACTGTACCCCTCCAGGGGCCCGAGCCCTTGCCAGCCCAATGACACCTTGAAGTCACCACTTTTCCTTTCTTGCCCGCTAATA
AAACCTATTTAAACAGGAAATTCATACCAAATGCAAATGGGTTTTGTTTTCCTTGGCATTTTGTTGTTCCGATCACAGATTTCCCTGCCA
GGGTGTCTGTGGTTATCAGCTGCAGGCTCAGCTTGGGGCGGCCGCTTCACACAAGCCACTCTGTACCACGTGCCCTACCTTAGTGACGGG

>95041_95041_2_TTC39C-CABLES1_TTC39C_chr18_21595002_ENST00000584250_CABLES1_chr18_20837191_ENST00000256925_length(amino acids)=206AA_BP=
MYCLKSWSDSLKPLLSSMLMPARASSASCRGAAAAAAASESPSSRRRGRCCSEPAMGVRGPALGRGEIGSSCCGPARARSPALPARSQAE
PGGEGRGGEKTGGKRREGPRREEPRPGCGAAWEVGVRPPPRGLLSSTRPLLSRPPKHPTRAGPEAESVSGCLSPRQAGPRAAAASTSCSP

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Fusion Gene PPI Analysis for TTC39C-CABLES1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCABLES1chr18:21595002chr18:20837191ENST00000256925810179_492587.0634.0CDK3
TgeneCABLES1chr18:21595002chr18:20837191ENST00000400473810179_492260.0307.0CDK3
TgeneCABLES1chr18:21595002chr18:20837191ENST00000420687810179_492322.0369.0CDK3
TgeneCABLES1chr18:21595002chr18:20837191ENST000002569258101_109587.0634.0TDRD7
TgeneCABLES1chr18:21595002chr18:20837191ENST000004004738101_109260.0307.0TDRD7
TgeneCABLES1chr18:21595002chr18:20837191ENST000004206878101_109322.0369.0TDRD7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTC39C-CABLES1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTC39C-CABLES1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource