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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TTC39C-NPC1 (FusionGDB2 ID:95046)

Fusion Gene Summary for TTC39C-NPC1

Fusion gene summary

Fusion gene information	Fusion gene name: TTC39C-NPC1
	Fusion gene ID: 95046
		Hgene	Tgene
	Gene symbol	TTC39C	NPC1
	Gene ID	125488	4864
	Gene name	tetratricopeptide repeat domain 39C	NPC intracellular cholesterol transporter 1
	Synonyms	C18orf17\|HsT2697	NPC\|POGZ\|SLC65A1
	Cytomap	18q11.2	18q11.2
	Type of gene	protein-coding	protein-coding
	Description	tetratricopeptide repeat protein 39CTPR repeat protein 39C	NPC intracellular cholesterol transporter 1Niemann-Pick C1 proteintruncated Niemann-Pick C1
	Modification date	20200313	20200315
	UniProtAcc	.	NPC1L1
	Ensembl transtripts involved in fusion gene	ENST00000304621, ENST00000317571, ENST00000540918, ENST00000577185, ENST00000578150, ENST00000584250,	ENST00000412552, ENST00000540608, ENST00000269228,
Fusion gene scores	* DoF score	6 X 5 X 5=150	12 X 11 X 5=660
	# samples	6	13
	** MAII score	log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/660*10)=-2.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TTC39C [Title/Abstract] AND NPC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TTC39C(21663045)-NPC1(21153538), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NPC1	GO:0006486	protein glycosylation	10821832
Tgene	NPC1	GO:0030301	cholesterol transport	18772377
Tgene	NPC1	GO:0033344	cholesterol efflux	16141411
Tgene	NPC1	GO:0042632	cholesterol homeostasis	12719428
Tgene	NPC1	GO:0090150	establishment of protein localization to membrane	23360953

Fusion gene breakpoints across TTC39C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NPC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-8526-01A	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-

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Fusion Gene ORF analysis for TTC39C-NPC1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000304621	ENST00000412552	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
5CDS-intron	ENST00000304621	ENST00000540608	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
5CDS-intron	ENST00000317571	ENST00000412552	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
5CDS-intron	ENST00000317571	ENST00000540608	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
In-frame	ENST00000304621	ENST00000269228	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
In-frame	ENST00000317571	ENST00000269228	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-3CDS	ENST00000540918	ENST00000269228	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-3CDS	ENST00000577185	ENST00000269228	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-3CDS	ENST00000578150	ENST00000269228	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-3CDS	ENST00000584250	ENST00000269228	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-intron	ENST00000540918	ENST00000412552	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-intron	ENST00000540918	ENST00000540608	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-intron	ENST00000577185	ENST00000412552	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-intron	ENST00000577185	ENST00000540608	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-intron	ENST00000578150	ENST00000412552	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-intron	ENST00000578150	ENST00000540608	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-intron	ENST00000584250	ENST00000412552	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-
intron-intron	ENST00000584250	ENST00000540608	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000304621	TTC39C	chr18	21663045	-	ENST00000269228	NPC1	chr18	21153538	-	5628	1083	282	4862	1526
ENST00000317571	TTC39C	chr18	21663045	-	ENST00000269228	NPC1	chr18	21153538	-	5765	1220	191	4999	1602

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000304621	ENST00000269228	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-	0.000227896	0.99977213
ENST00000317571	ENST00000269228	TTC39C	chr18	21663045	-	NPC1	chr18	21153538	-	0.00032372	0.99967635

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Fusion Genomic Features for TTC39C-NPC1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTC39C-NPC1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:21663045/chr18:21153538)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NPC1 NPC1L1
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	1359

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000304621

19_25

267

523.0

Compositional bias

Note=Poly-Ala

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000317571

19_25

328

584.0

Compositional bias

Note=Poly-Ala

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

249_259

1279.0

Compositional bias

Note=Poly-Pro

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

620_785

1279.0

Domain

SSD

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

175_205

1279.0

Region

Note=Important for cholesterol binding and cholesterol transfer from NPC1 to liposomes

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

1119_1124

1279.0

Topological domain

Cytoplasmic

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

1146_1150

1279.0

Topological domain

Lumenal

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

1172_1194

1279.0

Topological domain

Cytoplasmic

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

1216_1223

1279.0

Topological domain

Lumenal

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

1245_1278

1279.0

Topological domain

Cytoplasmic

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

23_261

1279.0

Topological domain

Lumenal

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

283_350

1279.0

Topological domain

Cytoplasmic

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

372_620

1279.0

Topological domain

Lumenal

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

642_653

1279.0

Topological domain

Cytoplasmic

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

676_685

1279.0

Topological domain

Lumenal

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

707_730

1279.0

Topological domain

Cytoplasmic

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

752_759

1279.0

Topological domain

Lumenal

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

784_832

1279.0

Topological domain

Cytoplasmic

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

854_1097

1279.0

Topological domain

Lumenal

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

1098_1118

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

1125_1145

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

1151_1171

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

1195_1215

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

1224_1244

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

262_282

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

351_371

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

621_641

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

654_675

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

686_706

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

731_751

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

760_783

1279.0

Transmembrane

Helical

Tgene

NPC1

chr18:21663045

chr18:21153538

ENST00000269228

833_853

1279.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000584250

19_25

77.0

Compositional bias

Note=Poly-Ala

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000304621

315_348

267

523.0

Repeat

Note=TPR 1

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000304621

353_386

267

523.0

Repeat

Note=TPR 2

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000304621

485_518

267

523.0

Repeat

Note=TPR 3

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000317571

315_348

328

584.0

Repeat

Note=TPR 1

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000317571

353_386

328

584.0

Repeat

Note=TPR 2

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000317571

485_518

328

584.0

Repeat

Note=TPR 3

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000584250

315_348

77.0

Repeat

Note=TPR 1

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000584250

353_386

77.0

Repeat

Note=TPR 2

Hgene

TTC39C

chr18:21663045

chr18:21153538

ENST00000584250

485_518

77.0

Repeat

Note=TPR 3

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Fusion Gene Sequence for TTC39C-NPC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>95046_95046_1_TTC39C-NPC1_TTC39C_chr18_21663045_ENST00000304621_NPC1_chr18_21153538_ENST00000269228_length(transcript)=5628nt_BP=1083nt
AATCATGCTTACGCATATAGGTTAACCACAGTTATGTAAGCAGGTTCTGAGAAAAGGTGAGAAAGAGAATGGAGAGTTTTGCTACAACAG
AGGCAGGATTCTGAATTTATTTCCAGCTGCCCATCTTGTCCCTCCTGGAGACCTAACCCCTCCAGCACCTACACACACAGCCTCTTTAGA
AGCAACTATCCTGCCACTGGCTCAGAAAGGCTGAGTCCTAAGAATTCTAAAATCTTGCTCCTAAGAAATCTCAAGCTTCTTTTGTGAAAT
CATAGCCCACTAATGAGTTTTGGAGCCAGCTTTGTCAGTTTTTTGAATGCCATGATGACATTTGAGGAAGAAAAAATGCAGTTGGCATGT
GATGACTTAAAAACCACAGAAAAACTGTGTGAAAGTGAAGAGGCTGGAGTAATTGAAACAATCAAGAATAAAATTAAGAAGAACGTTGAT
GTCCGAAAATCCGCCCCCTCTATGGTTGATCGGCTTCAGAGGCAGATAATCATAGCTGACTGCCAGGTTTACCTGGCTGTGCTTTCATTT
GTAAAACAAGAATTGTCAGCTTATATCAAAGGTGGGTGGATCCTTAGGAAAGCCTGGAAGATTTACAATAAATGCTATCTGGACATCAAT
GCCCTTCAGGAGCTGTATCAGAAGAAGCTAACTGAAGAGTCCTTGACTTCTGATGCTGCAAATGATAATCACATTGTGGCTGAAGGGGTG
TCTGAGGAGTCTCTGAACAGACTGAAAGGTGCTGTTAGCTTTGGATATGGCCTTTTTCACCTTTGCATATCCATGGTGCCCCCAAACCTG
CTCAAAATCATCAACCTGCTGGGTTTTCCTGGAGACCGCCTACAGGGGCTTTCTTCACTGATGTATGCAAGCGAAAGTAAGGACATGAAG
GCCCCTTTAGCTACATTAGCTCTGCTCTGGTATCATACTGTAGTCCGCCCGTTTTTTGCCTTGGATGGCAGTGATAACAAGGCAGGCCTG
GATGAAGCTAAGGAAATTCTCCTTAAAAAAGAAGCTGCTTATCCAAATTCTTCCCTCTTTATGTTTTTCAAGGGACGGATACAACGACTA
GAGGTGTTTTCACAGTCCTGTGTTTGGTATGGAGAGTGTGGAATTGCATATGGGGACAAGAGGTACAATTGCGAATATTCTGGCCCACCA
AAACCATTGCCAAAGGATGGATATGACTTAGTGCAGGAACTCTGTCCAGGATTCTTCTTTGGCAATGTCAGTCTCTGTTGTGATGTTCGG
CAGCTTCAGACACTAAAAGACAACCTGCAGCTGCCTCTACAGTTTCTGTCCAGATGTCCATCCTGTTTTTATAACCTACTGAACCTGTTT
TGTGAGCTGACATGTAGCCCTCGACAGAGTCAGTTTTTGAATGTTACAGCTACTGAAGATTATGTTGATCCTGTTACAAACCAGACGAAA
ACAAATGTGAAAGAGTTACAATACTACGTCGGACAGAGTTTTGCCAATGCAATGTACAATGCCTGCCGGGATGTGGAGGCCCCCTCAAGT
AATGACAAGGCCCTGGGACTCCTGTGTGGGAAGGACGCTGACGCCTGTAATGCCACCAACTGGATTGAATACATGTTCAATAAGGACAAT
GGACAGGCACCTTTTACCATCACTCCTGTGTTTTCAGATTTTCCAGTCCATGGGATGGAGCCCATGAACAATGCCACCAAAGGCTGTGAC
GAGTCTGTGGATGAGGTCACAGCACCATGTAGCTGCCAAGACTGCTCTATTGTCTGTGGCCCCAAGCCCCAGCCCCCACCTCCTCCTGCT
CCCTGGACGATCCTTGGCTTGGACGCCATGTATGTCATCATGTGGATCACCTACATGGCGTTTTTGCTTGTGTTTTTTGGAGCATTTTTT
GCAGTGTGGTGCTACAGAAAACGGTATTTTGTCTCCGAGTACACTCCCATCGATAGCAATATAGCTTTTTCTGTTAATGCAAGTGACAAA
GGAGAGGCGTCCTGCTGTGACCCTGTCAGCGCAGCATTTGAGGGCTGCTTGAGGCGGCTGTTCACACGCTGGGGGTCTTTCTGCGTCCGA
AACCCTGGCTGTGTCATTTTCTTCTCGCTGGTCTTCATTACTGCGTGTTCGTCAGGCCTGGTGTTTGTCCGGGTCACAACCAATCCAGTT
GACCTCTGGTCAGCCCCCAGCAGCCAGGCTCGCCTGGAAAAAGAGTACTTTGACCAGCACTTTGGGCCTTTCTTCCGGACGGAGCAGCTC
ATCATCCGGGCCCCTCTCACTGACAAACACATTTACCAGCCATACCCTTCGGGAGCTGATGTACCCTTTGGACCTCCGCTTGACATACAG
ATACTGCACCAGGTTCTTGACTTACAAATAGCCATCGAAAACATTACTGCCTCTTATGACAATGAGACTGTGACACTTCAAGACATCTGC
TTGGCCCCTCTTTCACCGTATAACACGAACTGCACCATTTTGAGTGTGTTAAATTACTTCCAGAACAGCCATTCCGTGCTGGACCACAAG
AAAGGGGACGACTTCTTTGTGTATGCCGATTACCACACGCACTTTCTGTACTGCGTACGGGCTCCTGCCTCTCTGAATGATACAAGTTTG
CTCCATGACCCTTGTCTGGGTACGTTTGGTGGACCAGTGTTCCCGTGGCTTGTGTTGGGAGGCTATGATGATCAAAACTACAATAACGCC
ACTGCCCTTGTGATTACCTTCCCTGTCAATAATTACTATAATGATACAGAGAAGCTCCAGAGGGCCCAGGCCTGGGAAAAAGAGTTTATT
AATTTTGTGAAAAACTACAAGAATCCCAATCTGACCATTTCCTTCACTGCTGAACGAAGTATTGAAGATGAACTAAATCGTGAAAGTGAC
AGTGATGTCTTCACCGTTGTAATTAGCTATGCCATCATGTTTCTATATATTTCCCTAGCCTTGGGGCACATGAAAAGCTGTCGCAGGCTT
CTGGTGGATTCGAAGGTCTCACTAGGCATCGCGGGCATCTTGATCGTGCTGAGCTCGGTGGCTTGCTCCTTGGGTGTCTTCAGCTACATT
GGGTTGCCCTTGACCCTCATTGTGATTGAAGTCATCCCGTTCCTGGTGCTGGCTGTTGGAGTGGACAACATCTTCATTCTGGTGCAGGCC
TACCAGAGAGATGAACGTCTTCAAGGGGAAACCCTGGATCAGCAGCTGGGCAGGGTCCTAGGAGAAGTGGCTCCCAGTATGTTCCTGTCA
TCCTTTTCTGAGACTGTAGCATTTTTCTTAGGAGCATTGTCCGTGATGCCAGCCGTGCACACCTTCTCTCTCTTTGCGGGATTGGCAGTC
TTCATTGACTTTCTTCTGCAGATTACCTGTTTCGTGAGTCTCTTGGGGTTAGACATTAAACGTCAAGAGAAAAATCGGCTAGACATCTTT
TGCTGTGTCAGAGGTGCTGAAGATGGAACAAGCGTCCAGGCCTCAGAGAGCTGTTTGTTTCGCTTCTTCAAAAACTCCTATTCTCCACTT
CTGCTAAAGGACTGGATGAGACCAATTGTGATAGCAATATTTGTGGGTGTTCTGTCATTCAGCATCGCAGTCCTGAACAAAGTAGATATT
GGATTGGATCAGTCTCTTTCGATGCCAGATGACTCCTACATGGTGGATTATTTCAAATCCATCAGTCAGTACCTGCATGCGGGTCCGCCT
GTGTACTTTGTCCTGGAGGAAGGGCACGACTACACTTCTTCCAAGGGGCAGAACATGGTGTGCGGCGGCATGGGCTGCAACAATGATTCC
CTGGTGCAGCAGATATTTAACGCGGCGCAGCTGGACAACTATACCCGAATAGGCTTCGCCCCCTCGTCCTGGATCGACGATTATTTCGAC
TGGGTGAAGCCACAGTCGTCTTGCTGTCGAGTGGACAATATCACTGACCAGTTCTGCAATGCTTCAGTGGTTGACCCTGCCTGCGTTCGC
TGCAGGCCTCTGACTCCGGAAGGCAAACAGAGGCCTCAGGGGGGAGACTTCATGAGATTCCTGCCCATGTTCCTTTCGGATAACCCTAAC
CCCAAGTGTGGCAAAGGGGGACATGCTGCCTATAGTTCTGCAGTTAACATCCTCCTTGGCCATGGCACCAGGGTCGGAGCCACGTACTTC
ATGACCTACCACACCGTGCTGCAGACCTCTGCTGACTTTATTGACGCTCTGAAGAAAGCCCGACTTATAGCCAGTAATGTCACCGAAACC
ATGGGCATTAACGGCAGTGCCTACCGAGTATTTCCTTACAGTGTGTTTTATGTCTTCTACGAACAGTACCTGACCATCATTGACGACACT
ATCTTCAACCTCGGTGTGTCCCTGGGCGCGATATTTCTGGTGACCATGGTCCTCCTGGGCTGTGAGCTCTGGTCTGCAGTCATCATGTGT
GCCACCATCGCCATGGTCTTGGTCAACATGTTTGGAGTTATGTGGCTCTGGGGCATCAGTCTGAACGCTGTATCCTTGGTCAACCTGGTG
ATGAGCTGTGGCATCTCCGTGGAGTTCTGCAGCCACATAACCAGAGCGTTCACGGTGAGCATGAAAGGCAGCCGCGTGGAGCGCGCGGAA
GAGGCACTTGCCCACATGGGCAGCTCCGTGTTCAGTGGAATCACACTTACAAAATTTGGAGGGATTGTGGTGTTGGCTTTTGCCAAATCT
CAAATTTTCCAGATATTCTACTTCAGGATGTATTTGGCCATGGTCTTACTGGGAGCCACTCACGGATTAATATTTCTCCCTGTCTTACTC
AGTTACATAGGGCCATCAGTAAATAAAGCCAAAAGTTGTGCCACTGAAGAGCGATACAAAGGAACAGAGCGCGAACGGCTTCTAAATTTC
TAGCCCTCTCGCAGGGCATCCTGACTGAACTGTGTCTAAGGGTCGGTCGGTTTACCACTGGACGGGTGCTGCATCGGCAAGGCCAAGTTG
AACACCGGATGGTGCCAACCATCGGTTGTTTGGCAGCAGCTTTGAACGTAGCGCCTGTGAACTCAGGAATGCACAGTTGACTTGGGAAGC
AGTATTACTAGATCTGGAGGCAACCACAGGACACTAAACTTCTCCCAGCCTCTTCAGGAAAGAAACCTCATTCTTTGGCAAGCAGGAGGT
GACACTAGATGGCTGTGAATGTGATCCGCTCACTGACACTCTGTAAAGGCCAATCAATGCACTGTCTGTCTCTCCTTTTAGGAGTAAGCC
ATCCCACAAGTTCTATACCATATTTTTAGTGACAGTTGAGGTTGTAGATACACTTTATAACATTTTATAGTTTAAAGAGCTTTATTAATG
CAATAAATTAACTTTGTACACATTTTTATATAAAAAAACAGCAAGTGATTTCAGAATGTTGTAGGCCTCATTAGAGCTTGGTCTCCAAAA
ATCTGTTTGAAAAAAGCAACATGTTCTTCACAGTGTTCCCCTAGAAAGGAAGAGATTTAATTGCCAGTTAGATGTGGCATGAAATGAGGG
ACAAAGAAAGCATCTCGTAGGTGTGTCTACTGGGTTTTAACTTATTTTTCTTTAATAAAATACATTGTTTTCCTAAGTTTTGGGGTTACC

>95046_95046_1_TTC39C-NPC1_TTC39C_chr18_21663045_ENST00000304621_NPC1_chr18_21153538_ENST00000269228_length(amino acids)=1526AA_BP=265
MSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCESEEAGVIETIKNKIKKNVDVRKSAPSMVDRLQRQIIIADCQVYLAVLSFVKQE
LSAYIKGGWILRKAWKIYNKCYLDINALQELYQKKLTEESLTSDAANDNHIVAEGVSEESLNRLKGAVSFGYGLFHLCISMVPPNLLKII
NLLGFPGDRLQGLSSLMYASESKDMKAPLATLALLWYHTVVRPFFALDGSDNKAGLDEAKEILLKKEAAYPNSSLFMFFKGRIQRLEVFS
QSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELT
CSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAP
FTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWC
YRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWS
APSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPL
SPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALV
ITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDS
KVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSE
TVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKD
WMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQ
IFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCG
KGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNL
GVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALA

--------------------------------------------------------------
>95046_95046_2_TTC39C-NPC1_TTC39C_chr18_21663045_ENST00000317571_NPC1_chr18_21153538_ENST00000269228_length(transcript)=5765nt_BP=1220nt
TGAGTAATCCCCGCGGCGGCGGCCGGACGCCCACCTCCCACGCCGCGCCGCAGCCGGGCCGCGGCTCCTCCCTCCGCGGTCCTTCCCTCC
TCTTCCCTCCCGTCTTCTCCCCTCCCCTCCCCTCCCCTCCCGGCTCCGCTTGGCTCCGGGCAGGTAGAGCCGGGCTCCGGGCGCGCGCGG
GGCCGCAGCAGCTGCTCCCGATCTCGCCTCGGCCCAGCGCAGGGCCTCGCACGCCCATGGCCGGCTCGGAGCAGCAGCGGCCGCGGCGGC
GGGACGACGGAGACTCGGACGCGGCAGCGGCGGCGGCGGCGCCCCTGCAGGACGCGGAGCTGGCCCTGGCCGGCATCAACATGCTGCTCA
ACAACGGCTTCAGGGAGTCGGACCAGCTTTTCAAACAATACAGAAATCATAGCCCACTAATGAGTTTTGGAGCCAGCTTTGTCAGTTTTT
TGAATGCCATGATGACATTTGAGGAAGAAAAAATGCAGTTGGCATGTGATGACTTAAAAACCACAGAAAAACTGTGTGAAAGTGAAGAGG
CTGGAGTAATTGAAACAATCAAGAATAAAATTAAGAAGAACGTTGATGTCCGAAAATCCGCCCCCTCTATGGTTGATCGGCTTCAGAGGC
AGATAATCATAGCTGACTGCCAGGTTTACCTGGCTGTGCTTTCATTTGTAAAACAAGAATTGTCAGCTTATATCAAAGGTGGGTGGATCC
TTAGGAAAGCCTGGAAGATTTACAATAAATGCTATCTGGACATCAATGCCCTTCAGGAGCTGTATCAGAAGAAGCTAACTGAAGAGTCCT
TGACTTCTGATGCTGCAAATGATAATCACATTGTGGCTGAAGGGGTGTCTGAGGAGTCTCTGAACAGACTGAAAGGTGCTGTTAGCTTTG
GATATGGCCTTTTTCACCTTTGCATATCCATGGTGCCCCCAAACCTGCTCAAAATCATCAACCTGCTGGGTTTTCCTGGAGACCGCCTAC
AGGGGCTTTCTTCACTGATGTATGCAAGCGAAAGTAAGGACATGAAGGCCCCTTTAGCTACATTAGCTCTGCTCTGGTATCATACTGTAG
TCCGCCCGTTTTTTGCCTTGGATGGCAGTGATAACAAGGCAGGCCTGGATGAAGCTAAGGAAATTCTCCTTAAAAAAGAAGCTGCTTATC
CAAATTCTTCCCTCTTTATGTTTTTCAAGGGACGGATACAACGACTAGAGGTGTTTTCACAGTCCTGTGTTTGGTATGGAGAGTGTGGAA
TTGCATATGGGGACAAGAGGTACAATTGCGAATATTCTGGCCCACCAAAACCATTGCCAAAGGATGGATATGACTTAGTGCAGGAACTCT
GTCCAGGATTCTTCTTTGGCAATGTCAGTCTCTGTTGTGATGTTCGGCAGCTTCAGACACTAAAAGACAACCTGCAGCTGCCTCTACAGT
TTCTGTCCAGATGTCCATCCTGTTTTTATAACCTACTGAACCTGTTTTGTGAGCTGACATGTAGCCCTCGACAGAGTCAGTTTTTGAATG
TTACAGCTACTGAAGATTATGTTGATCCTGTTACAAACCAGACGAAAACAAATGTGAAAGAGTTACAATACTACGTCGGACAGAGTTTTG
CCAATGCAATGTACAATGCCTGCCGGGATGTGGAGGCCCCCTCAAGTAATGACAAGGCCCTGGGACTCCTGTGTGGGAAGGACGCTGACG
CCTGTAATGCCACCAACTGGATTGAATACATGTTCAATAAGGACAATGGACAGGCACCTTTTACCATCACTCCTGTGTTTTCAGATTTTC
CAGTCCATGGGATGGAGCCCATGAACAATGCCACCAAAGGCTGTGACGAGTCTGTGGATGAGGTCACAGCACCATGTAGCTGCCAAGACT
GCTCTATTGTCTGTGGCCCCAAGCCCCAGCCCCCACCTCCTCCTGCTCCCTGGACGATCCTTGGCTTGGACGCCATGTATGTCATCATGT
GGATCACCTACATGGCGTTTTTGCTTGTGTTTTTTGGAGCATTTTTTGCAGTGTGGTGCTACAGAAAACGGTATTTTGTCTCCGAGTACA
CTCCCATCGATAGCAATATAGCTTTTTCTGTTAATGCAAGTGACAAAGGAGAGGCGTCCTGCTGTGACCCTGTCAGCGCAGCATTTGAGG
GCTGCTTGAGGCGGCTGTTCACACGCTGGGGGTCTTTCTGCGTCCGAAACCCTGGCTGTGTCATTTTCTTCTCGCTGGTCTTCATTACTG
CGTGTTCGTCAGGCCTGGTGTTTGTCCGGGTCACAACCAATCCAGTTGACCTCTGGTCAGCCCCCAGCAGCCAGGCTCGCCTGGAAAAAG
AGTACTTTGACCAGCACTTTGGGCCTTTCTTCCGGACGGAGCAGCTCATCATCCGGGCCCCTCTCACTGACAAACACATTTACCAGCCAT
ACCCTTCGGGAGCTGATGTACCCTTTGGACCTCCGCTTGACATACAGATACTGCACCAGGTTCTTGACTTACAAATAGCCATCGAAAACA
TTACTGCCTCTTATGACAATGAGACTGTGACACTTCAAGACATCTGCTTGGCCCCTCTTTCACCGTATAACACGAACTGCACCATTTTGA
GTGTGTTAAATTACTTCCAGAACAGCCATTCCGTGCTGGACCACAAGAAAGGGGACGACTTCTTTGTGTATGCCGATTACCACACGCACT
TTCTGTACTGCGTACGGGCTCCTGCCTCTCTGAATGATACAAGTTTGCTCCATGACCCTTGTCTGGGTACGTTTGGTGGACCAGTGTTCC
CGTGGCTTGTGTTGGGAGGCTATGATGATCAAAACTACAATAACGCCACTGCCCTTGTGATTACCTTCCCTGTCAATAATTACTATAATG
ATACAGAGAAGCTCCAGAGGGCCCAGGCCTGGGAAAAAGAGTTTATTAATTTTGTGAAAAACTACAAGAATCCCAATCTGACCATTTCCT
TCACTGCTGAACGAAGTATTGAAGATGAACTAAATCGTGAAAGTGACAGTGATGTCTTCACCGTTGTAATTAGCTATGCCATCATGTTTC
TATATATTTCCCTAGCCTTGGGGCACATGAAAAGCTGTCGCAGGCTTCTGGTGGATTCGAAGGTCTCACTAGGCATCGCGGGCATCTTGA
TCGTGCTGAGCTCGGTGGCTTGCTCCTTGGGTGTCTTCAGCTACATTGGGTTGCCCTTGACCCTCATTGTGATTGAAGTCATCCCGTTCC
TGGTGCTGGCTGTTGGAGTGGACAACATCTTCATTCTGGTGCAGGCCTACCAGAGAGATGAACGTCTTCAAGGGGAAACCCTGGATCAGC
AGCTGGGCAGGGTCCTAGGAGAAGTGGCTCCCAGTATGTTCCTGTCATCCTTTTCTGAGACTGTAGCATTTTTCTTAGGAGCATTGTCCG
TGATGCCAGCCGTGCACACCTTCTCTCTCTTTGCGGGATTGGCAGTCTTCATTGACTTTCTTCTGCAGATTACCTGTTTCGTGAGTCTCT
TGGGGTTAGACATTAAACGTCAAGAGAAAAATCGGCTAGACATCTTTTGCTGTGTCAGAGGTGCTGAAGATGGAACAAGCGTCCAGGCCT
CAGAGAGCTGTTTGTTTCGCTTCTTCAAAAACTCCTATTCTCCACTTCTGCTAAAGGACTGGATGAGACCAATTGTGATAGCAATATTTG
TGGGTGTTCTGTCATTCAGCATCGCAGTCCTGAACAAAGTAGATATTGGATTGGATCAGTCTCTTTCGATGCCAGATGACTCCTACATGG
TGGATTATTTCAAATCCATCAGTCAGTACCTGCATGCGGGTCCGCCTGTGTACTTTGTCCTGGAGGAAGGGCACGACTACACTTCTTCCA
AGGGGCAGAACATGGTGTGCGGCGGCATGGGCTGCAACAATGATTCCCTGGTGCAGCAGATATTTAACGCGGCGCAGCTGGACAACTATA
CCCGAATAGGCTTCGCCCCCTCGTCCTGGATCGACGATTATTTCGACTGGGTGAAGCCACAGTCGTCTTGCTGTCGAGTGGACAATATCA
CTGACCAGTTCTGCAATGCTTCAGTGGTTGACCCTGCCTGCGTTCGCTGCAGGCCTCTGACTCCGGAAGGCAAACAGAGGCCTCAGGGGG
GAGACTTCATGAGATTCCTGCCCATGTTCCTTTCGGATAACCCTAACCCCAAGTGTGGCAAAGGGGGACATGCTGCCTATAGTTCTGCAG
TTAACATCCTCCTTGGCCATGGCACCAGGGTCGGAGCCACGTACTTCATGACCTACCACACCGTGCTGCAGACCTCTGCTGACTTTATTG
ACGCTCTGAAGAAAGCCCGACTTATAGCCAGTAATGTCACCGAAACCATGGGCATTAACGGCAGTGCCTACCGAGTATTTCCTTACAGTG
TGTTTTATGTCTTCTACGAACAGTACCTGACCATCATTGACGACACTATCTTCAACCTCGGTGTGTCCCTGGGCGCGATATTTCTGGTGA
CCATGGTCCTCCTGGGCTGTGAGCTCTGGTCTGCAGTCATCATGTGTGCCACCATCGCCATGGTCTTGGTCAACATGTTTGGAGTTATGT
GGCTCTGGGGCATCAGTCTGAACGCTGTATCCTTGGTCAACCTGGTGATGAGCTGTGGCATCTCCGTGGAGTTCTGCAGCCACATAACCA
GAGCGTTCACGGTGAGCATGAAAGGCAGCCGCGTGGAGCGCGCGGAAGAGGCACTTGCCCACATGGGCAGCTCCGTGTTCAGTGGAATCA
CACTTACAAAATTTGGAGGGATTGTGGTGTTGGCTTTTGCCAAATCTCAAATTTTCCAGATATTCTACTTCAGGATGTATTTGGCCATGG
TCTTACTGGGAGCCACTCACGGATTAATATTTCTCCCTGTCTTACTCAGTTACATAGGGCCATCAGTAAATAAAGCCAAAAGTTGTGCCA
CTGAAGAGCGATACAAAGGAACAGAGCGCGAACGGCTTCTAAATTTCTAGCCCTCTCGCAGGGCATCCTGACTGAACTGTGTCTAAGGGT
CGGTCGGTTTACCACTGGACGGGTGCTGCATCGGCAAGGCCAAGTTGAACACCGGATGGTGCCAACCATCGGTTGTTTGGCAGCAGCTTT
GAACGTAGCGCCTGTGAACTCAGGAATGCACAGTTGACTTGGGAAGCAGTATTACTAGATCTGGAGGCAACCACAGGACACTAAACTTCT
CCCAGCCTCTTCAGGAAAGAAACCTCATTCTTTGGCAAGCAGGAGGTGACACTAGATGGCTGTGAATGTGATCCGCTCACTGACACTCTG
TAAAGGCCAATCAATGCACTGTCTGTCTCTCCTTTTAGGAGTAAGCCATCCCACAAGTTCTATACCATATTTTTAGTGACAGTTGAGGTT
GTAGATACACTTTATAACATTTTATAGTTTAAAGAGCTTTATTAATGCAATAAATTAACTTTGTACACATTTTTATATAAAAAAACAGCA
AGTGATTTCAGAATGTTGTAGGCCTCATTAGAGCTTGGTCTCCAAAAATCTGTTTGAAAAAAGCAACATGTTCTTCACAGTGTTCCCCTA
GAAAGGAAGAGATTTAATTGCCAGTTAGATGTGGCATGAAATGAGGGACAAAGAAAGCATCTCGTAGGTGTGTCTACTGGGTTTTAACTT
ATTTTTCTTTAATAAAATACATTGTTTTCCTAAGTTTTGGGGTTACCCTATCTGCTTTGAGAGACAAATACAAAAGCTAAATGGAAGAGA

>95046_95046_2_TTC39C-NPC1_TTC39C_chr18_21663045_ENST00000317571_NPC1_chr18_21153538_ENST00000269228_length(amino acids)=1602AA_BP=341
MLPISPRPSAGPRTPMAGSEQQRPRRRDDGDSDAAAAAAAPLQDAELALAGINMLLNNGFRESDQLFKQYRNHSPLMSFGASFVSFLNAM
MTFEEEKMQLACDDLKTTEKLCESEEAGVIETIKNKIKKNVDVRKSAPSMVDRLQRQIIIADCQVYLAVLSFVKQELSAYIKGGWILRKA
WKIYNKCYLDINALQELYQKKLTEESLTSDAANDNHIVAEGVSEESLNRLKGAVSFGYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLS
SLMYASESKDMKAPLATLALLWYHTVVRPFFALDGSDNKAGLDEAKEILLKKEAAYPNSSLFMFFKGRIQRLEVFSQSCVWYGECGIAYG
DKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTAT
EDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHG
MEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVSEYTPID
SNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFD
QHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCTILSVLN
YFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEK
LQRAQAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLS
SVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPA
VHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVL
SFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG
FAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNIL
LGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVL
LGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TTC39C-NPC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TTC39C-NPC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TTC39C-NPC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source