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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTC3-UBR5 (FusionGDB2 ID:95071)

Fusion Gene Summary for TTC3-UBR5

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC3-UBR5
Fusion gene ID: 95071
HgeneTgene
Gene symbol

TTC3

UBR5

Gene ID

7267

51366

Gene nametetratricopeptide repeat domain 3ubiquitin protein ligase E3 component n-recognin 5
SynonymsDCRR1|RNF105|TPRDIIIDD5|EDD|EDD1|HYD
Cytomap

21q22.13

8q22.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TTC3RING finger protein 105RING-type E3 ubiquitin transferase TTC3TPR repeat protein 3TPR repeat protein Dtetratricopeptide repeat protein 3E3 ubiquitin-protein ligase UBR5E3 identified by differential displayE3 ubiquitin-protein ligase, HECT domain-containing 1HECT-type E3 ubiquitin transferase UBR5hyperplastic discs protein homologprogestin-induced protein
Modification date2020032020200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000479930, ENST00000354749, 
ENST00000355666, ENST00000399017, 
ENST00000399010, ENST00000540756, 
ENST00000220959, ENST00000518205, 
ENST00000520539, ENST00000521922, 
ENST00000519528, 
Fusion gene scores* DoF score20 X 15 X 11=330014 X 17 X 10=2380
# samples 2019
** MAII scorelog2(20/3300*10)=-4.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2380*10)=-3.64689024986436
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTC3 [Title/Abstract] AND UBR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTC3(38538884)-UBR5(103273392), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTC3

GO:0006511

ubiquitin-dependent protein catabolic process

20059950

HgeneTTC3

GO:0070936

protein K48-linked ubiquitination

20059950

TgeneUBR5

GO:0000209

protein polyubiquitination

21118991|28689657

TgeneUBR5

GO:0006974

cellular response to DNA damage stimulus

12011095

TgeneUBR5

GO:0010628

positive regulation of gene expression

18076571

TgeneUBR5

GO:0050847

progesterone receptor signaling pathway

12011095

TgeneUBR5

GO:0070936

protein K48-linked ubiquitination

28689657


check buttonFusion gene breakpoints across TTC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW363719TTC3chr21

38538884

+UBR5chr8

103273392

-


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Fusion Gene ORF analysis for TTC3-UBR5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000479930ENST00000220959TTC3chr21

38538884

+UBR5chr8

103273392

-
3UTR-3CDSENST00000479930ENST00000518205TTC3chr21

38538884

+UBR5chr8

103273392

-
3UTR-3CDSENST00000479930ENST00000520539TTC3chr21

38538884

+UBR5chr8

103273392

-
3UTR-3CDSENST00000479930ENST00000521922TTC3chr21

38538884

+UBR5chr8

103273392

-
3UTR-intronENST00000479930ENST00000519528TTC3chr21

38538884

+UBR5chr8

103273392

-
5CDS-intronENST00000354749ENST00000519528TTC3chr21

38538884

+UBR5chr8

103273392

-
5CDS-intronENST00000355666ENST00000519528TTC3chr21

38538884

+UBR5chr8

103273392

-
5CDS-intronENST00000399017ENST00000519528TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000354749ENST00000220959TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000354749ENST00000518205TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000354749ENST00000520539TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000354749ENST00000521922TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000355666ENST00000220959TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000355666ENST00000518205TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000355666ENST00000520539TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000355666ENST00000521922TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000399017ENST00000220959TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000399017ENST00000518205TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000399017ENST00000520539TTC3chr21

38538884

+UBR5chr8

103273392

-
In-frameENST00000399017ENST00000521922TTC3chr21

38538884

+UBR5chr8

103273392

-
intron-3CDSENST00000399010ENST00000220959TTC3chr21

38538884

+UBR5chr8

103273392

-
intron-3CDSENST00000399010ENST00000518205TTC3chr21

38538884

+UBR5chr8

103273392

-
intron-3CDSENST00000399010ENST00000520539TTC3chr21

38538884

+UBR5chr8

103273392

-
intron-3CDSENST00000399010ENST00000521922TTC3chr21

38538884

+UBR5chr8

103273392

-
intron-3CDSENST00000540756ENST00000220959TTC3chr21

38538884

+UBR5chr8

103273392

-
intron-3CDSENST00000540756ENST00000518205TTC3chr21

38538884

+UBR5chr8

103273392

-
intron-3CDSENST00000540756ENST00000520539TTC3chr21

38538884

+UBR5chr8

103273392

-
intron-3CDSENST00000540756ENST00000521922TTC3chr21

38538884

+UBR5chr8

103273392

-
intron-intronENST00000399010ENST00000519528TTC3chr21

38538884

+UBR5chr8

103273392

-
intron-intronENST00000540756ENST00000519528TTC3chr21

38538884

+UBR5chr8

103273392

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355666TTC3chr2138538884+ENST00000520539UBR5chr8103273392-522634739635481150
ENST00000355666TTC3chr2138538884+ENST00000220959UBR5chr8103273392-450234739635481150
ENST00000355666TTC3chr2138538884+ENST00000518205UBR5chr8103273392-404034739635481150
ENST00000355666TTC3chr2138538884+ENST00000521922UBR5chr8103273392-404034739635481150
ENST00000399017TTC3chr2138538884+ENST00000520539UBR5chr8103273392-78686115270861901160
ENST00000399017TTC3chr2138538884+ENST00000220959UBR5chr8103273392-71446115270861901160
ENST00000399017TTC3chr2138538884+ENST00000518205UBR5chr8103273392-66826115270861901160
ENST00000399017TTC3chr2138538884+ENST00000521922UBR5chr8103273392-66826115270861901160
ENST00000354749TTC3chr2138538884+ENST00000520539UBR5chr8103273392-65894836145949111150
ENST00000354749TTC3chr2138538884+ENST00000220959UBR5chr8103273392-58654836145949111150
ENST00000354749TTC3chr2138538884+ENST00000518205UBR5chr8103273392-54034836145949111150
ENST00000354749TTC3chr2138538884+ENST00000521922UBR5chr8103273392-54034836145949111150

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355666ENST00000520539TTC3chr2138538884+UBR5chr8103273392-0.0001647170.99983525
ENST00000355666ENST00000220959TTC3chr2138538884+UBR5chr8103273392-0.0002514480.9997485
ENST00000355666ENST00000518205TTC3chr2138538884+UBR5chr8103273392-0.0003180290.99968195
ENST00000355666ENST00000521922TTC3chr2138538884+UBR5chr8103273392-0.0003180290.99968195
ENST00000399017ENST00000520539TTC3chr2138538884+UBR5chr8103273392-0.0020918630.9979081
ENST00000399017ENST00000220959TTC3chr2138538884+UBR5chr8103273392-0.0023095510.99769044
ENST00000399017ENST00000518205TTC3chr2138538884+UBR5chr8103273392-0.0024751910.9975248
ENST00000399017ENST00000521922TTC3chr2138538884+UBR5chr8103273392-0.0024751910.9975248
ENST00000354749ENST00000520539TTC3chr2138538884+UBR5chr8103273392-0.0006568730.9993431
ENST00000354749ENST00000220959TTC3chr2138538884+UBR5chr8103273392-0.0008142140.99918574
ENST00000354749ENST00000518205TTC3chr2138538884+UBR5chr8103273392-0.0009066780.9990933
ENST00000354749ENST00000521922TTC3chr2138538884+UBR5chr8103273392-0.0009066780.9990933

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Fusion Genomic Features for TTC3-UBR5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTC3-UBR5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:38538884/chr8:103273392)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390591528_153702800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390591671_168102800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390591762_176802800.0Compositional biasNote=Poly-Ala
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390591986_199702800.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390592036_205902800.0Compositional biasNote=Pro-rich
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390592329_234802800.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390592357_236602800.0Compositional biasNote=Arg/Asp-rich (mixed charge)
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390592489_250002800.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390592737_275702800.0Compositional biasNote=Pro-rich
TgeneUBR5chr21:38538884chr8:103273392ENST00000520539059940_94502800.0Compositional biasNote=Poly-Glu
TgeneUBR5chr21:38538884chr8:103273392ENST00000520539059980_98502800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390592377_245402800.0DomainPABC
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390592462_279902800.0DomainHECT
TgeneUBR5chr21:38538884chr8:103273392ENST000005205390591177_124502800.0Zinc fingerUBR-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+1451018_102902026.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+1451020_102902026.0Compositional biasNote=Poly-Lys
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+1451172_118502026.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+1451563_157902026.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+1451899_190202026.0Compositional biasNote=Poly-Lys
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+145453_45602026.0Compositional biasNote=Poly-Ser
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+1461018_102902026.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+1461020_102902026.0Compositional biasNote=Poly-Lys
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+1461172_118502026.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+1461563_157902026.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+1461899_190202026.0Compositional biasNote=Poly-Lys
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+146453_45602026.0Compositional biasNote=Poly-Ser
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+1461018_102902026.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+1461020_102902026.0Compositional biasNote=Poly-Lys
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+1461172_118502026.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+1461563_157902026.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+1461899_190202026.0Compositional biasNote=Poly-Lys
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+146453_45602026.0Compositional biasNote=Poly-Ser
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+145231_26402026.0RepeatNote=TPR 1
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+145266_29802026.0RepeatNote=TPR 2
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+145536_57202026.0RepeatNote=TPR 3
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+145576_60902026.0RepeatNote=TPR 4
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+146231_26402026.0RepeatNote=TPR 1
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+146266_29802026.0RepeatNote=TPR 2
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+146536_57202026.0RepeatNote=TPR 3
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+146576_60902026.0RepeatNote=TPR 4
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+146231_26402026.0RepeatNote=TPR 1
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+146266_29802026.0RepeatNote=TPR 2
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+146536_57202026.0RepeatNote=TPR 3
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+146576_60902026.0RepeatNote=TPR 4
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+1451957_199702026.0Zinc fingerRING-type
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+1461957_199702026.0Zinc fingerRING-type
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+1461957_199702026.0Zinc fingerRING-type


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Fusion Gene Sequence for TTC3-UBR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95071_95071_1_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000220959_length(transcript)=5865nt_BP=4836nt
CTGAACTAGTTGCCAGTGATCTTGAAACGTGACAGTAACCAAGAGATAAATAGGTGACAATGACAGGAAAATTAGATGTAGTAAAAGAGA
GTGTTTGAGAGCAGAAGCTATGGCAACTAAAGACTGGATTTGAATCCTTCCTAGCTTGGTGACATGAGCAAATTACTTGATTTAAGTGAG
CATTTTCCCATCTGTACAGTGGAGATAACGATAATTGTGCCTGCTAAGAAGAATTGCTGTGAAGATTAGTGAAATAATGCATGTAAAACA
TTTGGTACAGTATGTGACACATAGTACAAATAGTTTGCTAGGAAGATTGTTATTATTCTTCACTTGTGATATTGTGAAGTTTTCATACAG
CAAATTGGACATCATGAGATGGATTGATTAAATAAATAGATTTGAACTTCAAGGACTGGTAGTGTTCTTGCTTTGGAAAGAAGAAACTTG
GTTTATCCTAATAATAGTAGGATAATAATGGTGAAGTGATAGGTACAAGTAATAGTGTTTATGATGCGCTGGTGATGATAGGAAAAGAAA
GCCATTATATGGGCAAGAGCTAGAAGTAATAAAATGGTGCATTTTTCAGTGATGTTTGGCCTATGTAGCTATTCTCTGATAACTATAAAA
ATCCTTATTATTGAAGATTCTTCAGGAAAAAAAACCCTTAGTCTGAAACTTTACCACCAATCCCCCTTGCCCCCCATTGAAATACGTATT
TTTAAAACATGGCTTTTGATAATGTGAGGGTTTTTTCCTTTTTGCGATTTAGCAGTGCTGATTGTGTATTGCAGTAGTTGTGAGAGCATT
AGAAGCAGCAGTCGATAGGAGGATGGAAGGTCTGGATGCCGCCTTGGGGAGTTAGGAGATTGGCAGACTTACCCTGTACCACTCTAGCCC
TACTCCTTTGCCCAAGACAGAAACACACTGAGATGGATAGGAGAATATGAGCAGTTGATAGGAAAGTTCTCAGTGGAGTCAGGATTTAGG
TTAGGCCAGGAGATTGAGAATATAACAGTTTGTGTATGATGAAATGGCATATTTCACAGAATGCAGTAAAAGCAGGTAGGGTACAAGTGC
AGCAACAGGAAGATGTCTTTTCTTCATTCAGCAAACACTTATTTGAGAGCTTACCATGTGCTAGGCACATACAAAGATAAATAAGATGCC
CTTGATGATCCTCTATTTAAAGGAGACATGTAAACAGGTTAACTTAGAGTAGAGATGGTGAATATGTGAACCTGAGGAAAGGAAGAAATA
GATTAAATTATCTGGAGAGAGAGGAAAAGTCAGCAGAATGGGGACGAGAATCTTTCGGAGCTCAGTGTTCTGATAGGAGTTATTTCCTTG
GGCATAGGTTCCAAGTATTTTTCTAATATACCATAGAAGCCAGGAAAACTTTCTTCTGTTATCTCAAATGATTTAATTACTGACTTGAGT
TTGTGTTGTCTCCTTAGACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATGCCTTGTTAGAAGATTGCCC
TCACGTGGATGATTGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACTGTGATGGGGTGGGTGTGCA
ATATAAAGATTATATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAATTTCTGTCCTGCAAGATTA
TTGCGATGCCATTAAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCACGATTGCATCCCTGTGTGGA
CGCCAACAATTCACGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTGTGGATTTGGCAAAGAAAGT
TGCTAATGATTCATTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAATGGAAGAAGCTCTGAATTG
GATAAAATATGCAGGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAAGTATTTTCTTTACTGAATA
CAAGTACCACATAACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTATGGATTGTATAGAGGAAGG
AGAACTAATGAAAATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACACCAGAGCCATTGAATATAG
ACCTGAAAACTACCTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCACTCGGTGATGGAAAGAGAGC
CACTATTCTGAAGAACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAATATGACTGGGCCCTGCAAGC
AAACATAAAAGCTCAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAAAGTTACAAAAACAAATAGA
AGACCTACAAGGTCGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTAGGAGTTTATCAGCACCTAT
ATTTACTACTTCACTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACGGTGGTAATCAGAATCTAAA
GGTGGCGGATGAGGCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGCCTCCAAAACATAAAGGAAA
ACAAAAATCTCGAAACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGAAGAACATCTTGGAGAAACA
GTTTTCTAAATCTTCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTCAAGATGGCTATATGGCCTT
ATTGGAGCAGCGTTGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAATAAAGCAATTGAACCTGGC
CATGATTAACTATGTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAATTATCTGAAGCCGAAAACCA
GTTTAAGAGGATTATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAGTATATTTGAAAAAAAACAG
ATTTCTAGAAGCTCTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTTGGCCCACGAGTAATGTGAT
TATTGAAGAGTCTCAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTCCAGTGCCAGATGCCATTTG
TTGCTATCAGAAGTGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTATACGCATCAGCTGTTGCCA
GTACTGTAAAATAGAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTGACAAGGATTTTCTACAAGG
AATATGTCTTACCCCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTAAATGTGAATTTGAACACAA
GGTCATAAAAGAAAAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGACTGAAAGAAGACAAAAAATT
GAAGAGAAAGATCCAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAAGTAATCCACCCAAAAATGA
AGAGCAGAAAGAAACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAAAGCAGTATGCTGACAAGAT
TAAATCCGGCATACAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAGACTATACAACCTGTTTTTC
TAGCAGAAATTTTCTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAAAGACAAGAATATTTCTGCA
TGTTTTGAGTGAGCTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCTTAGATGCCACAGGAACTTT
CTTTTCTCGTTATGGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAATATGGTCACAAACTAGACTC
TATAGAAGGAAAGCAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGCTGCTAGAAGAACACAGAGA
CAAGTTCCCAGCATTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAAGGAAACAAGATAGTGGTGA
AGCACCGTTTAGTTCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGTTAGTTGGGTCTGGAACAAC
TTCAGTAACTTCAAATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAGGCCCATTTGCAGTGCCTGA
CCATCTTCGGCAAGATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCAATAAGAAGCTATGGGACAT
GAACCCAAAACAAAAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTACTTTTGGACATCAAGCCCA
TCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACT
TGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGT
TTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGG
AAGTTAATGCTGTCATACCCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGA
GCACTAGCAACATTTGGCTATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTA
CACTGTGATTTATCTTTTTGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGT
TCTTGTATAGAGGGAATAGGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGT
GGTTGGCTGCAACTGTGTATCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATA
AAAACCACTTTTATTGCGGTTTGACTGCATTGAGCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAGTAGA
GAAGATGAGCATGACAGAACGACAAGATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGC
AGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGTGCA

>95071_95071_1_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000220959_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------
>95071_95071_2_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000518205_length(transcript)=5403nt_BP=4836nt
CTGAACTAGTTGCCAGTGATCTTGAAACGTGACAGTAACCAAGAGATAAATAGGTGACAATGACAGGAAAATTAGATGTAGTAAAAGAGA
GTGTTTGAGAGCAGAAGCTATGGCAACTAAAGACTGGATTTGAATCCTTCCTAGCTTGGTGACATGAGCAAATTACTTGATTTAAGTGAG
CATTTTCCCATCTGTACAGTGGAGATAACGATAATTGTGCCTGCTAAGAAGAATTGCTGTGAAGATTAGTGAAATAATGCATGTAAAACA
TTTGGTACAGTATGTGACACATAGTACAAATAGTTTGCTAGGAAGATTGTTATTATTCTTCACTTGTGATATTGTGAAGTTTTCATACAG
CAAATTGGACATCATGAGATGGATTGATTAAATAAATAGATTTGAACTTCAAGGACTGGTAGTGTTCTTGCTTTGGAAAGAAGAAACTTG
GTTTATCCTAATAATAGTAGGATAATAATGGTGAAGTGATAGGTACAAGTAATAGTGTTTATGATGCGCTGGTGATGATAGGAAAAGAAA
GCCATTATATGGGCAAGAGCTAGAAGTAATAAAATGGTGCATTTTTCAGTGATGTTTGGCCTATGTAGCTATTCTCTGATAACTATAAAA
ATCCTTATTATTGAAGATTCTTCAGGAAAAAAAACCCTTAGTCTGAAACTTTACCACCAATCCCCCTTGCCCCCCATTGAAATACGTATT
TTTAAAACATGGCTTTTGATAATGTGAGGGTTTTTTCCTTTTTGCGATTTAGCAGTGCTGATTGTGTATTGCAGTAGTTGTGAGAGCATT
AGAAGCAGCAGTCGATAGGAGGATGGAAGGTCTGGATGCCGCCTTGGGGAGTTAGGAGATTGGCAGACTTACCCTGTACCACTCTAGCCC
TACTCCTTTGCCCAAGACAGAAACACACTGAGATGGATAGGAGAATATGAGCAGTTGATAGGAAAGTTCTCAGTGGAGTCAGGATTTAGG
TTAGGCCAGGAGATTGAGAATATAACAGTTTGTGTATGATGAAATGGCATATTTCACAGAATGCAGTAAAAGCAGGTAGGGTACAAGTGC
AGCAACAGGAAGATGTCTTTTCTTCATTCAGCAAACACTTATTTGAGAGCTTACCATGTGCTAGGCACATACAAAGATAAATAAGATGCC
CTTGATGATCCTCTATTTAAAGGAGACATGTAAACAGGTTAACTTAGAGTAGAGATGGTGAATATGTGAACCTGAGGAAAGGAAGAAATA
GATTAAATTATCTGGAGAGAGAGGAAAAGTCAGCAGAATGGGGACGAGAATCTTTCGGAGCTCAGTGTTCTGATAGGAGTTATTTCCTTG
GGCATAGGTTCCAAGTATTTTTCTAATATACCATAGAAGCCAGGAAAACTTTCTTCTGTTATCTCAAATGATTTAATTACTGACTTGAGT
TTGTGTTGTCTCCTTAGACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATGCCTTGTTAGAAGATTGCCC
TCACGTGGATGATTGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACTGTGATGGGGTGGGTGTGCA
ATATAAAGATTATATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAATTTCTGTCCTGCAAGATTA
TTGCGATGCCATTAAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCACGATTGCATCCCTGTGTGGA
CGCCAACAATTCACGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTGTGGATTTGGCAAAGAAAGT
TGCTAATGATTCATTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAATGGAAGAAGCTCTGAATTG
GATAAAATATGCAGGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAAGTATTTTCTTTACTGAATA
CAAGTACCACATAACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTATGGATTGTATAGAGGAAGG
AGAACTAATGAAAATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACACCAGAGCCATTGAATATAG
ACCTGAAAACTACCTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCACTCGGTGATGGAAAGAGAGC
CACTATTCTGAAGAACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAATATGACTGGGCCCTGCAAGC
AAACATAAAAGCTCAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAAAGTTACAAAAACAAATAGA
AGACCTACAAGGTCGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTAGGAGTTTATCAGCACCTAT
ATTTACTACTTCACTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACGGTGGTAATCAGAATCTAAA
GGTGGCGGATGAGGCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGCCTCCAAAACATAAAGGAAA
ACAAAAATCTCGAAACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGAAGAACATCTTGGAGAAACA
GTTTTCTAAATCTTCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTCAAGATGGCTATATGGCCTT
ATTGGAGCAGCGTTGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAATAAAGCAATTGAACCTGGC
CATGATTAACTATGTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAATTATCTGAAGCCGAAAACCA
GTTTAAGAGGATTATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAGTATATTTGAAAAAAAACAG
ATTTCTAGAAGCTCTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTTGGCCCACGAGTAATGTGAT
TATTGAAGAGTCTCAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTCCAGTGCCAGATGCCATTTG
TTGCTATCAGAAGTGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTATACGCATCAGCTGTTGCCA
GTACTGTAAAATAGAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTGACAAGGATTTTCTACAAGG
AATATGTCTTACCCCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTAAATGTGAATTTGAACACAA
GGTCATAAAAGAAAAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGACTGAAAGAAGACAAAAAATT
GAAGAGAAAGATCCAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAAGTAATCCACCCAAAAATGA
AGAGCAGAAAGAAACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAAAGCAGTATGCTGACAAGAT
TAAATCCGGCATACAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAGACTATACAACCTGTTTTTC
TAGCAGAAATTTTCTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAAAGACAAGAATATTTCTGCA
TGTTTTGAGTGAGCTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCTTAGATGCCACAGGAACTTT
CTTTTCTCGTTATGGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAATATGGTCACAAACTAGACTC
TATAGAAGGAAAGCAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGCTGCTAGAAGAACACAGAGA
CAAGTTCCCAGCATTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAAGGAAACAAGATAGTGGTGA
AGCACCGTTTAGTTCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGTTAGTTGGGTCTGGAACAAC
TTCAGTAACTTCAAATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAGGCCCATTTGCAGTGCCTGA
CCATCTTCGGCAAGATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCAATAAGAAGCTATGGGACAT
GAACCCAAAACAAAAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTACTTTTGGACATCAAGCCCA
TCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACT
TGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGT
TTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGG
AAGTTAATGCTGTCATACCCCCCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAGTAGAGAAGATGAGCAT
GACAGAACGACAAGATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAG
GCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGTGCAGAACAGCCCTTA

>95071_95071_2_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000518205_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------
>95071_95071_3_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000520539_length(transcript)=6589nt_BP=4836nt
CTGAACTAGTTGCCAGTGATCTTGAAACGTGACAGTAACCAAGAGATAAATAGGTGACAATGACAGGAAAATTAGATGTAGTAAAAGAGA
GTGTTTGAGAGCAGAAGCTATGGCAACTAAAGACTGGATTTGAATCCTTCCTAGCTTGGTGACATGAGCAAATTACTTGATTTAAGTGAG
CATTTTCCCATCTGTACAGTGGAGATAACGATAATTGTGCCTGCTAAGAAGAATTGCTGTGAAGATTAGTGAAATAATGCATGTAAAACA
TTTGGTACAGTATGTGACACATAGTACAAATAGTTTGCTAGGAAGATTGTTATTATTCTTCACTTGTGATATTGTGAAGTTTTCATACAG
CAAATTGGACATCATGAGATGGATTGATTAAATAAATAGATTTGAACTTCAAGGACTGGTAGTGTTCTTGCTTTGGAAAGAAGAAACTTG
GTTTATCCTAATAATAGTAGGATAATAATGGTGAAGTGATAGGTACAAGTAATAGTGTTTATGATGCGCTGGTGATGATAGGAAAAGAAA
GCCATTATATGGGCAAGAGCTAGAAGTAATAAAATGGTGCATTTTTCAGTGATGTTTGGCCTATGTAGCTATTCTCTGATAACTATAAAA
ATCCTTATTATTGAAGATTCTTCAGGAAAAAAAACCCTTAGTCTGAAACTTTACCACCAATCCCCCTTGCCCCCCATTGAAATACGTATT
TTTAAAACATGGCTTTTGATAATGTGAGGGTTTTTTCCTTTTTGCGATTTAGCAGTGCTGATTGTGTATTGCAGTAGTTGTGAGAGCATT
AGAAGCAGCAGTCGATAGGAGGATGGAAGGTCTGGATGCCGCCTTGGGGAGTTAGGAGATTGGCAGACTTACCCTGTACCACTCTAGCCC
TACTCCTTTGCCCAAGACAGAAACACACTGAGATGGATAGGAGAATATGAGCAGTTGATAGGAAAGTTCTCAGTGGAGTCAGGATTTAGG
TTAGGCCAGGAGATTGAGAATATAACAGTTTGTGTATGATGAAATGGCATATTTCACAGAATGCAGTAAAAGCAGGTAGGGTACAAGTGC
AGCAACAGGAAGATGTCTTTTCTTCATTCAGCAAACACTTATTTGAGAGCTTACCATGTGCTAGGCACATACAAAGATAAATAAGATGCC
CTTGATGATCCTCTATTTAAAGGAGACATGTAAACAGGTTAACTTAGAGTAGAGATGGTGAATATGTGAACCTGAGGAAAGGAAGAAATA
GATTAAATTATCTGGAGAGAGAGGAAAAGTCAGCAGAATGGGGACGAGAATCTTTCGGAGCTCAGTGTTCTGATAGGAGTTATTTCCTTG
GGCATAGGTTCCAAGTATTTTTCTAATATACCATAGAAGCCAGGAAAACTTTCTTCTGTTATCTCAAATGATTTAATTACTGACTTGAGT
TTGTGTTGTCTCCTTAGACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATGCCTTGTTAGAAGATTGCCC
TCACGTGGATGATTGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACTGTGATGGGGTGGGTGTGCA
ATATAAAGATTATATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAATTTCTGTCCTGCAAGATTA
TTGCGATGCCATTAAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCACGATTGCATCCCTGTGTGGA
CGCCAACAATTCACGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTGTGGATTTGGCAAAGAAAGT
TGCTAATGATTCATTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAATGGAAGAAGCTCTGAATTG
GATAAAATATGCAGGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAAGTATTTTCTTTACTGAATA
CAAGTACCACATAACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTATGGATTGTATAGAGGAAGG
AGAACTAATGAAAATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACACCAGAGCCATTGAATATAG
ACCTGAAAACTACCTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCACTCGGTGATGGAAAGAGAGC
CACTATTCTGAAGAACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAATATGACTGGGCCCTGCAAGC
AAACATAAAAGCTCAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAAAGTTACAAAAACAAATAGA
AGACCTACAAGGTCGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTAGGAGTTTATCAGCACCTAT
ATTTACTACTTCACTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACGGTGGTAATCAGAATCTAAA
GGTGGCGGATGAGGCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGCCTCCAAAACATAAAGGAAA
ACAAAAATCTCGAAACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGAAGAACATCTTGGAGAAACA
GTTTTCTAAATCTTCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTCAAGATGGCTATATGGCCTT
ATTGGAGCAGCGTTGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAATAAAGCAATTGAACCTGGC
CATGATTAACTATGTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAATTATCTGAAGCCGAAAACCA
GTTTAAGAGGATTATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAGTATATTTGAAAAAAAACAG
ATTTCTAGAAGCTCTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTTGGCCCACGAGTAATGTGAT
TATTGAAGAGTCTCAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTCCAGTGCCAGATGCCATTTG
TTGCTATCAGAAGTGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTATACGCATCAGCTGTTGCCA
GTACTGTAAAATAGAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTGACAAGGATTTTCTACAAGG
AATATGTCTTACCCCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTAAATGTGAATTTGAACACAA
GGTCATAAAAGAAAAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGACTGAAAGAAGACAAAAAATT
GAAGAGAAAGATCCAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAAGTAATCCACCCAAAAATGA
AGAGCAGAAAGAAACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAAAGCAGTATGCTGACAAGAT
TAAATCCGGCATACAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAGACTATACAACCTGTTTTTC
TAGCAGAAATTTTCTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAAAGACAAGAATATTTCTGCA
TGTTTTGAGTGAGCTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCTTAGATGCCACAGGAACTTT
CTTTTCTCGTTATGGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAATATGGTCACAAACTAGACTC
TATAGAAGGAAAGCAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGCTGCTAGAAGAACACAGAGA
CAAGTTCCCAGCATTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAAGGAAACAAGATAGTGGTGA
AGCACCGTTTAGTTCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGTTAGTTGGGTCTGGAACAAC
TTCAGTAACTTCAAATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAGGCCCATTTGCAGTGCCTGA
CCATCTTCGGCAAGATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCAATAAGAAGCTATGGGACAT
GAACCCAAAACAAAAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTACTTTTGGACATCAAGCCCA
TCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACT
TGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGT
TTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGG
AAGTTAATGCTGTCATACCCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGA
GCACTAGCAACATTTGGCTATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTA
CACTGTGATTTATCTTTTTGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGT
TCTTGTATAGAGGGAATAGGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGT
GGTTGGCTGCAACTGTGTATCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATA
AAAACCACTTTTATTGCGGTTTGACTGCATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCATGTAATTTGCTCATTTGAGT
GAGGGCACTTTTTTTGTACATATGATGGGGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCA
GTCAGTCTCAAGAGGTTACTGCACTTCAGTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCT
GATAACTGTAAAATGTTTTATAAGATCATGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGT
ATCTAGCCTTTTTTAAGTATCTTGTTACATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGTAATATTGAAGAAACAATAG
TTTTTATTTATGTAGTTGTACATTTTTAAACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTTTGACTTAAAGAACTGGAAG
TTTATATACACCTGGACTATAAGAAACAGAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCAC
CTTTTCATTTTACAAATGGGGGAAGTGAAGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAATAACTGACAGGTTTTTGTT
TTGATGACCTATTAATTATGTAGCCTAGGATTAATATCCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG
TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAA
CGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAG

>95071_95071_3_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000520539_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------
>95071_95071_4_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000521922_length(transcript)=5403nt_BP=4836nt
CTGAACTAGTTGCCAGTGATCTTGAAACGTGACAGTAACCAAGAGATAAATAGGTGACAATGACAGGAAAATTAGATGTAGTAAAAGAGA
GTGTTTGAGAGCAGAAGCTATGGCAACTAAAGACTGGATTTGAATCCTTCCTAGCTTGGTGACATGAGCAAATTACTTGATTTAAGTGAG
CATTTTCCCATCTGTACAGTGGAGATAACGATAATTGTGCCTGCTAAGAAGAATTGCTGTGAAGATTAGTGAAATAATGCATGTAAAACA
TTTGGTACAGTATGTGACACATAGTACAAATAGTTTGCTAGGAAGATTGTTATTATTCTTCACTTGTGATATTGTGAAGTTTTCATACAG
CAAATTGGACATCATGAGATGGATTGATTAAATAAATAGATTTGAACTTCAAGGACTGGTAGTGTTCTTGCTTTGGAAAGAAGAAACTTG
GTTTATCCTAATAATAGTAGGATAATAATGGTGAAGTGATAGGTACAAGTAATAGTGTTTATGATGCGCTGGTGATGATAGGAAAAGAAA
GCCATTATATGGGCAAGAGCTAGAAGTAATAAAATGGTGCATTTTTCAGTGATGTTTGGCCTATGTAGCTATTCTCTGATAACTATAAAA
ATCCTTATTATTGAAGATTCTTCAGGAAAAAAAACCCTTAGTCTGAAACTTTACCACCAATCCCCCTTGCCCCCCATTGAAATACGTATT
TTTAAAACATGGCTTTTGATAATGTGAGGGTTTTTTCCTTTTTGCGATTTAGCAGTGCTGATTGTGTATTGCAGTAGTTGTGAGAGCATT
AGAAGCAGCAGTCGATAGGAGGATGGAAGGTCTGGATGCCGCCTTGGGGAGTTAGGAGATTGGCAGACTTACCCTGTACCACTCTAGCCC
TACTCCTTTGCCCAAGACAGAAACACACTGAGATGGATAGGAGAATATGAGCAGTTGATAGGAAAGTTCTCAGTGGAGTCAGGATTTAGG
TTAGGCCAGGAGATTGAGAATATAACAGTTTGTGTATGATGAAATGGCATATTTCACAGAATGCAGTAAAAGCAGGTAGGGTACAAGTGC
AGCAACAGGAAGATGTCTTTTCTTCATTCAGCAAACACTTATTTGAGAGCTTACCATGTGCTAGGCACATACAAAGATAAATAAGATGCC
CTTGATGATCCTCTATTTAAAGGAGACATGTAAACAGGTTAACTTAGAGTAGAGATGGTGAATATGTGAACCTGAGGAAAGGAAGAAATA
GATTAAATTATCTGGAGAGAGAGGAAAAGTCAGCAGAATGGGGACGAGAATCTTTCGGAGCTCAGTGTTCTGATAGGAGTTATTTCCTTG
GGCATAGGTTCCAAGTATTTTTCTAATATACCATAGAAGCCAGGAAAACTTTCTTCTGTTATCTCAAATGATTTAATTACTGACTTGAGT
TTGTGTTGTCTCCTTAGACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATGCCTTGTTAGAAGATTGCCC
TCACGTGGATGATTGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACTGTGATGGGGTGGGTGTGCA
ATATAAAGATTATATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAATTTCTGTCCTGCAAGATTA
TTGCGATGCCATTAAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCACGATTGCATCCCTGTGTGGA
CGCCAACAATTCACGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTGTGGATTTGGCAAAGAAAGT
TGCTAATGATTCATTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAATGGAAGAAGCTCTGAATTG
GATAAAATATGCAGGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAAGTATTTTCTTTACTGAATA
CAAGTACCACATAACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTATGGATTGTATAGAGGAAGG
AGAACTAATGAAAATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACACCAGAGCCATTGAATATAG
ACCTGAAAACTACCTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCACTCGGTGATGGAAAGAGAGC
CACTATTCTGAAGAACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAATATGACTGGGCCCTGCAAGC
AAACATAAAAGCTCAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAAAGTTACAAAAACAAATAGA
AGACCTACAAGGTCGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTAGGAGTTTATCAGCACCTAT
ATTTACTACTTCACTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACGGTGGTAATCAGAATCTAAA
GGTGGCGGATGAGGCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGCCTCCAAAACATAAAGGAAA
ACAAAAATCTCGAAACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGAAGAACATCTTGGAGAAACA
GTTTTCTAAATCTTCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTCAAGATGGCTATATGGCCTT
ATTGGAGCAGCGTTGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAATAAAGCAATTGAACCTGGC
CATGATTAACTATGTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAATTATCTGAAGCCGAAAACCA
GTTTAAGAGGATTATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAGTATATTTGAAAAAAAACAG
ATTTCTAGAAGCTCTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTTGGCCCACGAGTAATGTGAT
TATTGAAGAGTCTCAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTCCAGTGCCAGATGCCATTTG
TTGCTATCAGAAGTGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTATACGCATCAGCTGTTGCCA
GTACTGTAAAATAGAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTGACAAGGATTTTCTACAAGG
AATATGTCTTACCCCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTAAATGTGAATTTGAACACAA
GGTCATAAAAGAAAAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGACTGAAAGAAGACAAAAAATT
GAAGAGAAAGATCCAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAAGTAATCCACCCAAAAATGA
AGAGCAGAAAGAAACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAAAGCAGTATGCTGACAAGAT
TAAATCCGGCATACAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAGACTATACAACCTGTTTTTC
TAGCAGAAATTTTCTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAAAGACAAGAATATTTCTGCA
TGTTTTGAGTGAGCTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCTTAGATGCCACAGGAACTTT
CTTTTCTCGTTATGGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAATATGGTCACAAACTAGACTC
TATAGAAGGAAAGCAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGCTGCTAGAAGAACACAGAGA
CAAGTTCCCAGCATTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAAGGAAACAAGATAGTGGTGA
AGCACCGTTTAGTTCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGTTAGTTGGGTCTGGAACAAC
TTCAGTAACTTCAAATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAGGCCCATTTGCAGTGCCTGA
CCATCTTCGGCAAGATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCAATAAGAAGCTATGGGACAT
GAACCCAAAACAAAAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTACTTTTGGACATCAAGCCCA
TCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACT
TGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGT
TTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGG
AAGTTAATGCTGTCATACCCCCCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAGTAGAGAAGATGAGCAT
GACAGAACGACAAGATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAG
GCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGTGCAGAACAGCCCTTA

>95071_95071_4_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000521922_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------
>95071_95071_5_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000220959_length(transcript)=4502nt_BP=3473nt
GTCGGCTGACGTGGAGGGCCGGAGGTGGCGGCGGCGGCGGCGGCGGCTGCTGCTGCTGCTGCCCGCGTCCGAGGCTCGCGGGCGGCGGGC
CCGGACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATGCCTTGTTAGAAGATTGCCCTCACGTGGATGAT
TGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACTGTGATGGGGTGGGTGTGCAATATAAAGATTAT
ATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAATTTCTGTCCTGCAAGATTATTGCGATGCCATT
AAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCACGATTGCATCCCTGTGTGGACGCCAACAATTCA
CGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTGTGGATTTGGCAAAGAAAGTTGCTAATGATTCA
TTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAATGGAAGAAGCTCTGAATTGGATAAAATATGCA
GGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAAGTATTTTCTTTACTGAATACAAGTACCACATA
ACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTATGGATTGTATAGAGGAAGGAGAACTAATGAAA
ATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACACCAGAGCCATTGAATATAGACCTGAAAACTAC
CTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCACTCGGTGATGGAAAGAGAGCCACTATTCTGAAG
AACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAATATGACTGGGCCCTGCAAGCAAACATAAAAGCT
CAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAAAGTTACAAAAACAAATAGAAGACCTACAAGGT
CGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTAGGAGTTTATCAGCACCTATATTTACTACTTCA
CTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACGGTGGTAATCAGAATCTAAAGGTGGCGGATGAG
GCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGCCTCCAAAACATAAAGGAAAACAAAAATCTCGA
AACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGAAGAACATCTTGGAGAAACAGTTTTCTAAATCT
TCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTCAAGATGGCTATATGGCCTTATTGGAGCAGCGT
TGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAATAAAGCAATTGAACCTGGCCATGATTAACTAT
GTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAATTATCTGAAGCCGAAAACCAGTTTAAGAGGATT
ATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAGTATATTTGAAAAAAAACAGATTTCTAGAAGCT
CTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTTGGCCCACGAGTAATGTGATTATTGAAGAGTCT
CAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTCCAGTGCCAGATGCCATTTGTTGCTATCAGAAG
TGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTATACGCATCAGCTGTTGCCAGTACTGTAAAATA
GAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTGACAAGGATTTTCTACAAGGAATATGTCTTACC
CCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTAAATGTGAATTTGAACACAAGGTCATAAAAGAA
AAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGACTGAAAGAAGACAAAAAATTGAAGAGAAAGATC
CAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAAGTAATCCACCCAAAAATGAAGAGCAGAAAGAA
ACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAAAGCAGTATGCTGACAAGATTAAATCCGGCATA
CAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAGACTATACAACCTGTTTTTCTAGCAGAAATTTT
CTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAAAGACAAGAATATTTCTGCATGTTTTGAGTGAG
CTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCTTAGATGCCACAGGAACTTTCTTTTCTCGTTAT
GGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAATATGGTCACAAACTAGACTCTATAGAAGGAAAG
CAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGCTGCTAGAAGAACACAGAGACAAGTTCCCAGCA
TTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAAGGAAACAAGATAGTGGTGAAGCACCGTTTAGT
TCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGTTAGTTGGGTCTGGAACAACTTCAGTAACTTCA
AATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAGGCCCATTTGCAGTGCCTGACCATCTTCGGCAA
GATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCAATAAGAAGCTATGGGACATGAACCCAAAACAA
AAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCA
GTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGAC
TTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTA
TAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGT
CATACCCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACAT
TTGGCTATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTAT
CTTTTTGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGG
GAATAGGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAAC
TGTGTATCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTA
TTGCGGTTTGACTGCATTGAGCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAGTAGAGAAGATGAGCATG
ACAGAACGACAAGATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGG
CTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGTGCAGAACAGCCCTTAC

>95071_95071_5_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000220959_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

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>95071_95071_6_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000518205_length(transcript)=4040nt_BP=3473nt
GTCGGCTGACGTGGAGGGCCGGAGGTGGCGGCGGCGGCGGCGGCGGCTGCTGCTGCTGCTGCCCGCGTCCGAGGCTCGCGGGCGGCGGGC
CCGGACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATGCCTTGTTAGAAGATTGCCCTCACGTGGATGAT
TGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACTGTGATGGGGTGGGTGTGCAATATAAAGATTAT
ATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAATTTCTGTCCTGCAAGATTATTGCGATGCCATT
AAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCACGATTGCATCCCTGTGTGGACGCCAACAATTCA
CGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTGTGGATTTGGCAAAGAAAGTTGCTAATGATTCA
TTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAATGGAAGAAGCTCTGAATTGGATAAAATATGCA
GGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAAGTATTTTCTTTACTGAATACAAGTACCACATA
ACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTATGGATTGTATAGAGGAAGGAGAACTAATGAAA
ATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACACCAGAGCCATTGAATATAGACCTGAAAACTAC
CTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCACTCGGTGATGGAAAGAGAGCCACTATTCTGAAG
AACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAATATGACTGGGCCCTGCAAGCAAACATAAAAGCT
CAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAAAGTTACAAAAACAAATAGAAGACCTACAAGGT
CGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTAGGAGTTTATCAGCACCTATATTTACTACTTCA
CTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACGGTGGTAATCAGAATCTAAAGGTGGCGGATGAG
GCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGCCTCCAAAACATAAAGGAAAACAAAAATCTCGA
AACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGAAGAACATCTTGGAGAAACAGTTTTCTAAATCT
TCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTCAAGATGGCTATATGGCCTTATTGGAGCAGCGT
TGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAATAAAGCAATTGAACCTGGCCATGATTAACTAT
GTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAATTATCTGAAGCCGAAAACCAGTTTAAGAGGATT
ATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAGTATATTTGAAAAAAAACAGATTTCTAGAAGCT
CTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTTGGCCCACGAGTAATGTGATTATTGAAGAGTCT
CAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTCCAGTGCCAGATGCCATTTGTTGCTATCAGAAG
TGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTATACGCATCAGCTGTTGCCAGTACTGTAAAATA
GAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTGACAAGGATTTTCTACAAGGAATATGTCTTACC
CCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTAAATGTGAATTTGAACACAAGGTCATAAAAGAA
AAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGACTGAAAGAAGACAAAAAATTGAAGAGAAAGATC
CAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAAGTAATCCACCCAAAAATGAAGAGCAGAAAGAA
ACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAAAGCAGTATGCTGACAAGATTAAATCCGGCATA
CAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAGACTATACAACCTGTTTTTCTAGCAGAAATTTT
CTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAAAGACAAGAATATTTCTGCATGTTTTGAGTGAG
CTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCTTAGATGCCACAGGAACTTTCTTTTCTCGTTAT
GGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAATATGGTCACAAACTAGACTCTATAGAAGGAAAG
CAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGCTGCTAGAAGAACACAGAGACAAGTTCCCAGCA
TTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAAGGAAACAAGATAGTGGTGAAGCACCGTTTAGT
TCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGTTAGTTGGGTCTGGAACAACTTCAGTAACTTCA
AATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAGGCCCATTTGCAGTGCCTGACCATCTTCGGCAA
GATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCAATAAGAAGCTATGGGACATGAACCCAAAACAA
AAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCA
GTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGAC
TTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTA
TAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGT
CATACCCCCCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAA
GATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAAT

>95071_95071_6_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000518205_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------
>95071_95071_7_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000520539_length(transcript)=5226nt_BP=3473nt
GTCGGCTGACGTGGAGGGCCGGAGGTGGCGGCGGCGGCGGCGGCGGCTGCTGCTGCTGCTGCCCGCGTCCGAGGCTCGCGGGCGGCGGGC
CCGGACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATGCCTTGTTAGAAGATTGCCCTCACGTGGATGAT
TGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACTGTGATGGGGTGGGTGTGCAATATAAAGATTAT
ATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAATTTCTGTCCTGCAAGATTATTGCGATGCCATT
AAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCACGATTGCATCCCTGTGTGGACGCCAACAATTCA
CGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTGTGGATTTGGCAAAGAAAGTTGCTAATGATTCA
TTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAATGGAAGAAGCTCTGAATTGGATAAAATATGCA
GGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAAGTATTTTCTTTACTGAATACAAGTACCACATA
ACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTATGGATTGTATAGAGGAAGGAGAACTAATGAAA
ATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACACCAGAGCCATTGAATATAGACCTGAAAACTAC
CTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCACTCGGTGATGGAAAGAGAGCCACTATTCTGAAG
AACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAATATGACTGGGCCCTGCAAGCAAACATAAAAGCT
CAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAAAGTTACAAAAACAAATAGAAGACCTACAAGGT
CGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTAGGAGTTTATCAGCACCTATATTTACTACTTCA
CTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACGGTGGTAATCAGAATCTAAAGGTGGCGGATGAG
GCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGCCTCCAAAACATAAAGGAAAACAAAAATCTCGA
AACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGAAGAACATCTTGGAGAAACAGTTTTCTAAATCT
TCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTCAAGATGGCTATATGGCCTTATTGGAGCAGCGT
TGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAATAAAGCAATTGAACCTGGCCATGATTAACTAT
GTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAATTATCTGAAGCCGAAAACCAGTTTAAGAGGATT
ATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAGTATATTTGAAAAAAAACAGATTTCTAGAAGCT
CTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTTGGCCCACGAGTAATGTGATTATTGAAGAGTCT
CAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTCCAGTGCCAGATGCCATTTGTTGCTATCAGAAG
TGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTATACGCATCAGCTGTTGCCAGTACTGTAAAATA
GAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTGACAAGGATTTTCTACAAGGAATATGTCTTACC
CCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTAAATGTGAATTTGAACACAAGGTCATAAAAGAA
AAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGACTGAAAGAAGACAAAAAATTGAAGAGAAAGATC
CAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAAGTAATCCACCCAAAAATGAAGAGCAGAAAGAA
ACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAAAGCAGTATGCTGACAAGATTAAATCCGGCATA
CAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAGACTATACAACCTGTTTTTCTAGCAGAAATTTT
CTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAAAGACAAGAATATTTCTGCATGTTTTGAGTGAG
CTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCTTAGATGCCACAGGAACTTTCTTTTCTCGTTAT
GGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAATATGGTCACAAACTAGACTCTATAGAAGGAAAG
CAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGCTGCTAGAAGAACACAGAGACAAGTTCCCAGCA
TTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAAGGAAACAAGATAGTGGTGAAGCACCGTTTAGT
TCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGTTAGTTGGGTCTGGAACAACTTCAGTAACTTCA
AATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAGGCCCATTTGCAGTGCCTGACCATCTTCGGCAA
GATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCAATAAGAAGCTATGGGACATGAACCCAAAACAA
AAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCA
GTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGAC
TTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTA
TAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGT
CATACCCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACAT
TTGGCTATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTAT
CTTTTTGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGG
GAATAGGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAAC
TGTGTATCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTA
TTGCGGTTTGACTGCATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCATGTAATTTGCTCATTTGAGTGAGGGCACTTTTT
TTGTACATATGATGGGGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCAGTCAGTCTCAAGA
GGTTACTGCACTTCAGTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCTGATAACTGTAAAA
TGTTTTATAAGATCATGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGTATCTAGCCTTTTT
TAAGTATCTTGTTACATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGTAATATTGAAGAAACAATAGTTTTTATTTATGT
AGTTGTACATTTTTAAACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTTTGACTTAAAGAACTGGAAGTTTATATACACCT
GGACTATAAGAAACAGAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCACCTTTTCATTTTAC
AAATGGGGGAAGTGAAGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAATAACTGACAGGTTTTTGTTTTGATGACCTATT
AATTATGTAGCCTAGGATTAATATCCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAGTAGAGAAGATGAG
CATGACAGAACGACAAGATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTT
TAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGTGCAGAACAGCCC

>95071_95071_7_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000520539_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------
>95071_95071_8_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000521922_length(transcript)=4040nt_BP=3473nt
GTCGGCTGACGTGGAGGGCCGGAGGTGGCGGCGGCGGCGGCGGCGGCTGCTGCTGCTGCTGCCCGCGTCCGAGGCTCGCGGGCGGCGGGC
CCGGACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATGCCTTGTTAGAAGATTGCCCTCACGTGGATGAT
TGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACTGTGATGGGGTGGGTGTGCAATATAAAGATTAT
ATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAATTTCTGTCCTGCAAGATTATTGCGATGCCATT
AAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCACGATTGCATCCCTGTGTGGACGCCAACAATTCA
CGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTGTGGATTTGGCAAAGAAAGTTGCTAATGATTCA
TTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAATGGAAGAAGCTCTGAATTGGATAAAATATGCA
GGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAAGTATTTTCTTTACTGAATACAAGTACCACATA
ACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTATGGATTGTATAGAGGAAGGAGAACTAATGAAA
ATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACACCAGAGCCATTGAATATAGACCTGAAAACTAC
CTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCACTCGGTGATGGAAAGAGAGCCACTATTCTGAAG
AACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAATATGACTGGGCCCTGCAAGCAAACATAAAAGCT
CAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAAAGTTACAAAAACAAATAGAAGACCTACAAGGT
CGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTAGGAGTTTATCAGCACCTATATTTACTACTTCA
CTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACGGTGGTAATCAGAATCTAAAGGTGGCGGATGAG
GCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGCCTCCAAAACATAAAGGAAAACAAAAATCTCGA
AACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGAAGAACATCTTGGAGAAACAGTTTTCTAAATCT
TCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTCAAGATGGCTATATGGCCTTATTGGAGCAGCGT
TGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAATAAAGCAATTGAACCTGGCCATGATTAACTAT
GTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAATTATCTGAAGCCGAAAACCAGTTTAAGAGGATT
ATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAGTATATTTGAAAAAAAACAGATTTCTAGAAGCT
CTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTTGGCCCACGAGTAATGTGATTATTGAAGAGTCT
CAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTCCAGTGCCAGATGCCATTTGTTGCTATCAGAAG
TGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTATACGCATCAGCTGTTGCCAGTACTGTAAAATA
GAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTGACAAGGATTTTCTACAAGGAATATGTCTTACC
CCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTAAATGTGAATTTGAACACAAGGTCATAAAAGAA
AAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGACTGAAAGAAGACAAAAAATTGAAGAGAAAGATC
CAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAAGTAATCCACCCAAAAATGAAGAGCAGAAAGAA
ACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAAAGCAGTATGCTGACAAGATTAAATCCGGCATA
CAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAGACTATACAACCTGTTTTTCTAGCAGAAATTTT
CTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAAAGACAAGAATATTTCTGCATGTTTTGAGTGAG
CTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCTTAGATGCCACAGGAACTTTCTTTTCTCGTTAT
GGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAATATGGTCACAAACTAGACTCTATAGAAGGAAAG
CAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGCTGCTAGAAGAACACAGAGACAAGTTCCCAGCA
TTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAAGGAAACAAGATAGTGGTGAAGCACCGTTTAGT
TCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGTTAGTTGGGTCTGGAACAACTTCAGTAACTTCA
AATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAGGCCCATTTGCAGTGCCTGACCATCTTCGGCAA
GATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCAATAAGAAGCTATGGGACATGAACCCAAAACAA
AAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCA
GTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGAC
TTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTA
TAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGT
CATACCCCCCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAA
GATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAAT

>95071_95071_8_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000521922_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

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>95071_95071_9_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000220959_length(transcript)=7144nt_BP=6115nt
TGTATTCTTTAAATATTATGTCTCATTAGTCTCTTCTCTCCTGCTGGAACTTTAACTGGATATATATATACACTAAACTGTTTCCAGATC
ACTTATTCTTTATCTTTCATATTTTTTATCTCTTTGTTTCTCTTTACCAGAATTTACAGTGCTGGATAATTTCATAAGGCATATATTTTA
GTTCACCAATTTTCTCTTCAACTGTGCCTAATATCCTCTGTAACCCATCCTGTCTCTTTTTTTTCTTTTAACAATTGCATTTTTAATTAC
TTTTTTTTTTTTTTTTTAAGATGGAGTCTCTCTCTGTCGCCCAGGCTGGAGTGCAGAGGCGCGATCTCAGCTCACTGCAAGCTCCGCCTC
CCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTTGTATTTT
TAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTCATCTGCTCACGTTGGCCTCCCAGAGTGCTGGG
ATTACAGGCATGAGCCACCATGCCCGGCCGCATTTTTAATTTCTAAAAGTTCTGCCTGGTTCTTTTTTGATATGTCCAGTCATTCTTCAT
GTTCTCATGTTATATGCTGATTTTTGTGACTCTATAGCTATTCTGTAGACTATATCAGACATTCCCAATGTCTGATATCCTTGAGGAGGG
GGATGTCTAAATTTATTGCTTTTTTGTTTTTTTTTCTGTTGTCTCTCCTCAATGTAGCTGTCACCTCATGTGTTTGGTGATCATTGATTA
TGAACTTCTGTTTGATCTTTGTGGTGATCTTGAGAGTCTAATTTGAGGATGCTTGCTTTCTGAAAGCATTTCTATCAGCTTTGTCTGGGA
GCCAGAAAGTTTAGCTGGCATCACTTTTGAGTTCCTACATTTTGCTTCTGGCCCAGGGCTCAGTGTCCTGATCCTATTACTGCTCTTGGC
ACCACTACTTGTAGCACTAAACTGTAGCCAGGTTTAATTTCTAGCTCAAGGTTTGTTGCTTTTGCGTGGAGAGGGTGCCTTCACATGTTC
CCCTATTTCTATGAGCTCAGCAAAAACATCCAAAAAGTGTTTTTTTTTTTAATCTAGGATATACCTTTTTCCTCCCAACAGTACATTCCC
CCAGAGTGTATAGTTGACCATAACTGATGGGATCAGAAGCTCTTTATTTTAATATTTAATTTTAGTAGTATATTTTTGTTTGATTGTATT
ATAAAAAATTTTATGGTACCAAGCAAGCTTTCTTGGTGATACCAACATTTCCATTAAAACTAGTTTACATCTAAGTTAAGATTTGAGTTA
TCCTAAAGAAAAGTATTAAGTAAATAGCAGTACAGATGGCAAATGGATTGCACAATATATCCTCTGGATCCATAGTGACCCTGCAGAGAT
AAACCTGTGATGGTCAAACAATGTGAAAACTGCTGTCAGAGACATGGGCAGGGTGCTCTTGTTTACAGAGAAGAGGTGCAAAAATCAACT
TGATGGTAGTGGGAAGATCAGGAAATGCTTCCTGAAATTGAGTATTAAGAACTAATAGACATTAGGTGGTTGCAGAATAAGTTTTGTTTA
GGAAGGACAAGCAGTTGGGTATGACTGGCTTCTAGGTTGTGTGTTGTGGAGTGACTGGGGATAAAAGCAGGAGCAAGATCACAAAAGGTC
TTCTATGCTTATATTAGGGAAGTTGGACTTTATTCTCAAGCTGAAGGGAAGCTGTTGCATGGTTTTAAGCAGTAAAGTGATATGATCAGA
GTTTTAGAGGATGCCAAGATTGAAGGCAAGTCTGACCAGTTAGGAGACTGCTTGTTAAATTAGTTCAGAGGAGAAACAGTGAAGGCAGTG
GCACTGGGCATGAAGAAGTATATGTGTGCTAATTTTAGATTTCTTAGGGAAGCAGAAATGACAAGAGTTAGTGGTCCATTGGACAGAAAT
ATTGAAGGAGACTGGGGAGTCTAGGTTGACTCCCAGGGTTTAGGTTTGGGCAGTAAAATGACATGTAGAACAATTAACTGATAAACAGCA
TACAGAAAGAGGAAAGAACTTCATTTCATATGTTTGTTTTTGAGGAAAAGATGTTTGTTTTTGAACTTCCTGATTCAGAGGGGCTTGTGG
GACATCTTGGTTAAGATCCTGTAGTAGTTCTAGTAGGGTCTAGAAGTCAAGAGATACAACCCCGCCTGGAAGGATTTGGGAGTCTTCAGC
ATTTGGAATTTTGGAAGCCATTGTTTACTGCAGTGCATATGAGATAATTTAAACTGGTACATAGATAAACACTTGAAAAAATTTTAATAG
ATAGGAATTTAATGTGTATGAGAAACATAACTTGCACATCTAACCTTTGATAATCATGGACATTATCACTTAGGCCAAGTGAGCTCAATA
AAAGGGAAATATTAACTAAAAATATATGTGATACATGGAAATGGCAAAAATCACGGTGAAGCTATGCAAACGATGCAAGTTCAGAAAGTG
CTGTGTTAAGTCATGGGTGTGGTGGATAAATTCACCCAAGGAGAGAGTAAGAGTGAGAAGAAAAGAGAGTTGACATTGGGTGGCGGGGAA
TGGAGAAGAAGAACCCATGAAGGAAACTGAGGAAGAGCAGCCAGACGAATAGGAGGAAAACCAGGAGAAGATGGTCTTTGGAGTCCAAAT
GAAGAGTTCTGAGGAGGAAGTGGTCCACAGCGTCAAACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATG
CCTTGTTAGAAGATTGCCCTCACGTGGATGATTGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACT
GTGATGGGGTGGGTGTGCAATATAAAGATTATATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAA
TTTCTGTCCTGCAAGATTATTGCGATGCCATTAAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCAC
GATTGCATCCCTGTGTGGACGCCAACAATTCACGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTG
TGGATTTGGCAAAGAAAGTTGCTAATGATTCATTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAA
TGGAAGAAGCTCTGAATTGGATAAAATATGCAGGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAA
GTATTTTCTTTACTGAATACAAGTACCACATAACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTA
TGGATTGTATAGAGGAAGGAGAACTAATGAAAATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACA
CCAGAGCCATTGAATATAGACCTGAAAACTACCTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCAC
TCGGTGATGGAAAGAGAGCCACTATTCTGAAGAACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAAT
ATGACTGGGCCCTGCAAGCAAACATAAAAGCTCAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAA
AGTTACAAAAACAAATAGAAGACCTACAAGGTCGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTA
GGAGTTTATCAGCACCTATATTTACTACTTCACTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACG
GTGGTAATCAGAATCTAAAGGTGGCGGATGAGGCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGC
CTCCAAAACATAAAGGAAAACAAAAATCTCGAAACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGA
AGAACATCTTGGAGAAACAGTTTTCTAAATCTTCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTC
AAGATGGCTATATGGCCTTATTGGAGCAGCGTTGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAA
TAAAGCAATTGAACCTGGCCATGATTAACTATGTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAAT
TATCTGAAGCCGAAAACCAGTTTAAGAGGATTATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAG
TATATTTGAAAAAAAACAGATTTCTAGAAGCTCTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTT
GGCCCACGAGTAATGTGATTATTGAAGAGTCTCAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTC
CAGTGCCAGATGCCATTTGTTGCTATCAGAAGTGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTA
TACGCATCAGCTGTTGCCAGTACTGTAAAATAGAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTG
ACAAGGATTTTCTACAAGGAATATGTCTTACCCCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTA
AATGTGAATTTGAACACAAGGTCATAAAAGAAAAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGAC
TGAAAGAAGACAAAAAATTGAAGAGAAAGATCCAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAA
GTAATCCACCCAAAAATGAAGAGCAGAAAGAAACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAA
AGCAGTATGCTGACAAGATTAAATCCGGCATACAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAG
ACTATACAACCTGTTTTTCTAGCAGAAATTTTCTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAA
AGACAAGAATATTTCTGCATGTTTTGAGTGAGCTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCT
TAGATGCCACAGGAACTTTCTTTTCTCGTTATGGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAAT
ATGGTCACAAACTAGACTCTATAGAAGGAAAGCAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGC
TGCTAGAAGAACACAGAGACAAGTTCCCAGCATTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAA
GGAAACAAGATAGTGGTGAAGCACCGTTTAGTTCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGT
TAGTTGGGTCTGGAACAACTTCAGTAACTTCAAATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAG
GCCCATTTGCAGTGCCTGACCATCTTCGGCAAGATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCA
ATAAGAAGCTATGGGACATGAACCCAAAACAAAAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTA
CTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACA
TCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCAT
TAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATT
TGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTA
TAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGAC
AGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGG
AAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTT
TTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGAT
GAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGCATTGAGCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTT
GGTTCTGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATT
CATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTT

>95071_95071_9_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000220959_length(amino acids)=1160AA_BP=
MRRKWSTASNLCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISV
LQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEE
ALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRA
IEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQ
KQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPK
HKGKQKSRNNESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQ
LNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPT
SNVIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKD
FLQGICLTPDCEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNP
PKNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTR
IFLHVLSELKEVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLE
EHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPF

--------------------------------------------------------------
>95071_95071_10_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000518205_length(transcript)=6682nt_BP=6115nt
TGTATTCTTTAAATATTATGTCTCATTAGTCTCTTCTCTCCTGCTGGAACTTTAACTGGATATATATATACACTAAACTGTTTCCAGATC
ACTTATTCTTTATCTTTCATATTTTTTATCTCTTTGTTTCTCTTTACCAGAATTTACAGTGCTGGATAATTTCATAAGGCATATATTTTA
GTTCACCAATTTTCTCTTCAACTGTGCCTAATATCCTCTGTAACCCATCCTGTCTCTTTTTTTTCTTTTAACAATTGCATTTTTAATTAC
TTTTTTTTTTTTTTTTTAAGATGGAGTCTCTCTCTGTCGCCCAGGCTGGAGTGCAGAGGCGCGATCTCAGCTCACTGCAAGCTCCGCCTC
CCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTTGTATTTT
TAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTCATCTGCTCACGTTGGCCTCCCAGAGTGCTGGG
ATTACAGGCATGAGCCACCATGCCCGGCCGCATTTTTAATTTCTAAAAGTTCTGCCTGGTTCTTTTTTGATATGTCCAGTCATTCTTCAT
GTTCTCATGTTATATGCTGATTTTTGTGACTCTATAGCTATTCTGTAGACTATATCAGACATTCCCAATGTCTGATATCCTTGAGGAGGG
GGATGTCTAAATTTATTGCTTTTTTGTTTTTTTTTCTGTTGTCTCTCCTCAATGTAGCTGTCACCTCATGTGTTTGGTGATCATTGATTA
TGAACTTCTGTTTGATCTTTGTGGTGATCTTGAGAGTCTAATTTGAGGATGCTTGCTTTCTGAAAGCATTTCTATCAGCTTTGTCTGGGA
GCCAGAAAGTTTAGCTGGCATCACTTTTGAGTTCCTACATTTTGCTTCTGGCCCAGGGCTCAGTGTCCTGATCCTATTACTGCTCTTGGC
ACCACTACTTGTAGCACTAAACTGTAGCCAGGTTTAATTTCTAGCTCAAGGTTTGTTGCTTTTGCGTGGAGAGGGTGCCTTCACATGTTC
CCCTATTTCTATGAGCTCAGCAAAAACATCCAAAAAGTGTTTTTTTTTTTAATCTAGGATATACCTTTTTCCTCCCAACAGTACATTCCC
CCAGAGTGTATAGTTGACCATAACTGATGGGATCAGAAGCTCTTTATTTTAATATTTAATTTTAGTAGTATATTTTTGTTTGATTGTATT
ATAAAAAATTTTATGGTACCAAGCAAGCTTTCTTGGTGATACCAACATTTCCATTAAAACTAGTTTACATCTAAGTTAAGATTTGAGTTA
TCCTAAAGAAAAGTATTAAGTAAATAGCAGTACAGATGGCAAATGGATTGCACAATATATCCTCTGGATCCATAGTGACCCTGCAGAGAT
AAACCTGTGATGGTCAAACAATGTGAAAACTGCTGTCAGAGACATGGGCAGGGTGCTCTTGTTTACAGAGAAGAGGTGCAAAAATCAACT
TGATGGTAGTGGGAAGATCAGGAAATGCTTCCTGAAATTGAGTATTAAGAACTAATAGACATTAGGTGGTTGCAGAATAAGTTTTGTTTA
GGAAGGACAAGCAGTTGGGTATGACTGGCTTCTAGGTTGTGTGTTGTGGAGTGACTGGGGATAAAAGCAGGAGCAAGATCACAAAAGGTC
TTCTATGCTTATATTAGGGAAGTTGGACTTTATTCTCAAGCTGAAGGGAAGCTGTTGCATGGTTTTAAGCAGTAAAGTGATATGATCAGA
GTTTTAGAGGATGCCAAGATTGAAGGCAAGTCTGACCAGTTAGGAGACTGCTTGTTAAATTAGTTCAGAGGAGAAACAGTGAAGGCAGTG
GCACTGGGCATGAAGAAGTATATGTGTGCTAATTTTAGATTTCTTAGGGAAGCAGAAATGACAAGAGTTAGTGGTCCATTGGACAGAAAT
ATTGAAGGAGACTGGGGAGTCTAGGTTGACTCCCAGGGTTTAGGTTTGGGCAGTAAAATGACATGTAGAACAATTAACTGATAAACAGCA
TACAGAAAGAGGAAAGAACTTCATTTCATATGTTTGTTTTTGAGGAAAAGATGTTTGTTTTTGAACTTCCTGATTCAGAGGGGCTTGTGG
GACATCTTGGTTAAGATCCTGTAGTAGTTCTAGTAGGGTCTAGAAGTCAAGAGATACAACCCCGCCTGGAAGGATTTGGGAGTCTTCAGC
ATTTGGAATTTTGGAAGCCATTGTTTACTGCAGTGCATATGAGATAATTTAAACTGGTACATAGATAAACACTTGAAAAAATTTTAATAG
ATAGGAATTTAATGTGTATGAGAAACATAACTTGCACATCTAACCTTTGATAATCATGGACATTATCACTTAGGCCAAGTGAGCTCAATA
AAAGGGAAATATTAACTAAAAATATATGTGATACATGGAAATGGCAAAAATCACGGTGAAGCTATGCAAACGATGCAAGTTCAGAAAGTG
CTGTGTTAAGTCATGGGTGTGGTGGATAAATTCACCCAAGGAGAGAGTAAGAGTGAGAAGAAAAGAGAGTTGACATTGGGTGGCGGGGAA
TGGAGAAGAAGAACCCATGAAGGAAACTGAGGAAGAGCAGCCAGACGAATAGGAGGAAAACCAGGAGAAGATGGTCTTTGGAGTCCAAAT
GAAGAGTTCTGAGGAGGAAGTGGTCCACAGCGTCAAACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATG
CCTTGTTAGAAGATTGCCCTCACGTGGATGATTGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACT
GTGATGGGGTGGGTGTGCAATATAAAGATTATATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAA
TTTCTGTCCTGCAAGATTATTGCGATGCCATTAAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCAC
GATTGCATCCCTGTGTGGACGCCAACAATTCACGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTG
TGGATTTGGCAAAGAAAGTTGCTAATGATTCATTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAA
TGGAAGAAGCTCTGAATTGGATAAAATATGCAGGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAA
GTATTTTCTTTACTGAATACAAGTACCACATAACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTA
TGGATTGTATAGAGGAAGGAGAACTAATGAAAATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACA
CCAGAGCCATTGAATATAGACCTGAAAACTACCTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCAC
TCGGTGATGGAAAGAGAGCCACTATTCTGAAGAACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAAT
ATGACTGGGCCCTGCAAGCAAACATAAAAGCTCAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAA
AGTTACAAAAACAAATAGAAGACCTACAAGGTCGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTA
GGAGTTTATCAGCACCTATATTTACTACTTCACTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACG
GTGGTAATCAGAATCTAAAGGTGGCGGATGAGGCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGC
CTCCAAAACATAAAGGAAAACAAAAATCTCGAAACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGA
AGAACATCTTGGAGAAACAGTTTTCTAAATCTTCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTC
AAGATGGCTATATGGCCTTATTGGAGCAGCGTTGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAA
TAAAGCAATTGAACCTGGCCATGATTAACTATGTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAAT
TATCTGAAGCCGAAAACCAGTTTAAGAGGATTATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAG
TATATTTGAAAAAAAACAGATTTCTAGAAGCTCTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTT
GGCCCACGAGTAATGTGATTATTGAAGAGTCTCAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTC
CAGTGCCAGATGCCATTTGTTGCTATCAGAAGTGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTA
TACGCATCAGCTGTTGCCAGTACTGTAAAATAGAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTG
ACAAGGATTTTCTACAAGGAATATGTCTTACCCCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTA
AATGTGAATTTGAACACAAGGTCATAAAAGAAAAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGAC
TGAAAGAAGACAAAAAATTGAAGAGAAAGATCCAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAA
GTAATCCACCCAAAAATGAAGAGCAGAAAGAAACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAA
AGCAGTATGCTGACAAGATTAAATCCGGCATACAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAG
ACTATACAACCTGTTTTTCTAGCAGAAATTTTCTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAA
AGACAAGAATATTTCTGCATGTTTTGAGTGAGCTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCT
TAGATGCCACAGGAACTTTCTTTTCTCGTTATGGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAAT
ATGGTCACAAACTAGACTCTATAGAAGGAAAGCAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGC
TGCTAGAAGAACACAGAGACAAGTTCCCAGCATTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAA
GGAAACAAGATAGTGGTGAAGCACCGTTTAGTTCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGT
TAGTTGGGTCTGGAACAACTTCAGTAACTTCAAATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAG
GCCCATTTGCAGTGCCTGACCATCTTCGGCAAGATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCA
ATAAGAAGCTATGGGACATGAACCCAAAACAAAAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTA
CTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACA
TCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCAT
TAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATT
TGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAA
TAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATT
TAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAAT

>95071_95071_10_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000518205_length(amino acids)=1160AA_BP=
MRRKWSTASNLCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISV
LQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEE
ALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRA
IEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQ
KQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPK
HKGKQKSRNNESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQ
LNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPT
SNVIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKD
FLQGICLTPDCEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNP
PKNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTR
IFLHVLSELKEVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLE
EHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPF

--------------------------------------------------------------
>95071_95071_11_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000520539_length(transcript)=7868nt_BP=6115nt
TGTATTCTTTAAATATTATGTCTCATTAGTCTCTTCTCTCCTGCTGGAACTTTAACTGGATATATATATACACTAAACTGTTTCCAGATC
ACTTATTCTTTATCTTTCATATTTTTTATCTCTTTGTTTCTCTTTACCAGAATTTACAGTGCTGGATAATTTCATAAGGCATATATTTTA
GTTCACCAATTTTCTCTTCAACTGTGCCTAATATCCTCTGTAACCCATCCTGTCTCTTTTTTTTCTTTTAACAATTGCATTTTTAATTAC
TTTTTTTTTTTTTTTTTAAGATGGAGTCTCTCTCTGTCGCCCAGGCTGGAGTGCAGAGGCGCGATCTCAGCTCACTGCAAGCTCCGCCTC
CCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTTGTATTTT
TAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTCATCTGCTCACGTTGGCCTCCCAGAGTGCTGGG
ATTACAGGCATGAGCCACCATGCCCGGCCGCATTTTTAATTTCTAAAAGTTCTGCCTGGTTCTTTTTTGATATGTCCAGTCATTCTTCAT
GTTCTCATGTTATATGCTGATTTTTGTGACTCTATAGCTATTCTGTAGACTATATCAGACATTCCCAATGTCTGATATCCTTGAGGAGGG
GGATGTCTAAATTTATTGCTTTTTTGTTTTTTTTTCTGTTGTCTCTCCTCAATGTAGCTGTCACCTCATGTGTTTGGTGATCATTGATTA
TGAACTTCTGTTTGATCTTTGTGGTGATCTTGAGAGTCTAATTTGAGGATGCTTGCTTTCTGAAAGCATTTCTATCAGCTTTGTCTGGGA
GCCAGAAAGTTTAGCTGGCATCACTTTTGAGTTCCTACATTTTGCTTCTGGCCCAGGGCTCAGTGTCCTGATCCTATTACTGCTCTTGGC
ACCACTACTTGTAGCACTAAACTGTAGCCAGGTTTAATTTCTAGCTCAAGGTTTGTTGCTTTTGCGTGGAGAGGGTGCCTTCACATGTTC
CCCTATTTCTATGAGCTCAGCAAAAACATCCAAAAAGTGTTTTTTTTTTTAATCTAGGATATACCTTTTTCCTCCCAACAGTACATTCCC
CCAGAGTGTATAGTTGACCATAACTGATGGGATCAGAAGCTCTTTATTTTAATATTTAATTTTAGTAGTATATTTTTGTTTGATTGTATT
ATAAAAAATTTTATGGTACCAAGCAAGCTTTCTTGGTGATACCAACATTTCCATTAAAACTAGTTTACATCTAAGTTAAGATTTGAGTTA
TCCTAAAGAAAAGTATTAAGTAAATAGCAGTACAGATGGCAAATGGATTGCACAATATATCCTCTGGATCCATAGTGACCCTGCAGAGAT
AAACCTGTGATGGTCAAACAATGTGAAAACTGCTGTCAGAGACATGGGCAGGGTGCTCTTGTTTACAGAGAAGAGGTGCAAAAATCAACT
TGATGGTAGTGGGAAGATCAGGAAATGCTTCCTGAAATTGAGTATTAAGAACTAATAGACATTAGGTGGTTGCAGAATAAGTTTTGTTTA
GGAAGGACAAGCAGTTGGGTATGACTGGCTTCTAGGTTGTGTGTTGTGGAGTGACTGGGGATAAAAGCAGGAGCAAGATCACAAAAGGTC
TTCTATGCTTATATTAGGGAAGTTGGACTTTATTCTCAAGCTGAAGGGAAGCTGTTGCATGGTTTTAAGCAGTAAAGTGATATGATCAGA
GTTTTAGAGGATGCCAAGATTGAAGGCAAGTCTGACCAGTTAGGAGACTGCTTGTTAAATTAGTTCAGAGGAGAAACAGTGAAGGCAGTG
GCACTGGGCATGAAGAAGTATATGTGTGCTAATTTTAGATTTCTTAGGGAAGCAGAAATGACAAGAGTTAGTGGTCCATTGGACAGAAAT
ATTGAAGGAGACTGGGGAGTCTAGGTTGACTCCCAGGGTTTAGGTTTGGGCAGTAAAATGACATGTAGAACAATTAACTGATAAACAGCA
TACAGAAAGAGGAAAGAACTTCATTTCATATGTTTGTTTTTGAGGAAAAGATGTTTGTTTTTGAACTTCCTGATTCAGAGGGGCTTGTGG
GACATCTTGGTTAAGATCCTGTAGTAGTTCTAGTAGGGTCTAGAAGTCAAGAGATACAACCCCGCCTGGAAGGATTTGGGAGTCTTCAGC
ATTTGGAATTTTGGAAGCCATTGTTTACTGCAGTGCATATGAGATAATTTAAACTGGTACATAGATAAACACTTGAAAAAATTTTAATAG
ATAGGAATTTAATGTGTATGAGAAACATAACTTGCACATCTAACCTTTGATAATCATGGACATTATCACTTAGGCCAAGTGAGCTCAATA
AAAGGGAAATATTAACTAAAAATATATGTGATACATGGAAATGGCAAAAATCACGGTGAAGCTATGCAAACGATGCAAGTTCAGAAAGTG
CTGTGTTAAGTCATGGGTGTGGTGGATAAATTCACCCAAGGAGAGAGTAAGAGTGAGAAGAAAAGAGAGTTGACATTGGGTGGCGGGGAA
TGGAGAAGAAGAACCCATGAAGGAAACTGAGGAAGAGCAGCCAGACGAATAGGAGGAAAACCAGGAGAAGATGGTCTTTGGAGTCCAAAT
GAAGAGTTCTGAGGAGGAAGTGGTCCACAGCGTCAAACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATG
CCTTGTTAGAAGATTGCCCTCACGTGGATGATTGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACT
GTGATGGGGTGGGTGTGCAATATAAAGATTATATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAA
TTTCTGTCCTGCAAGATTATTGCGATGCCATTAAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCAC
GATTGCATCCCTGTGTGGACGCCAACAATTCACGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTG
TGGATTTGGCAAAGAAAGTTGCTAATGATTCATTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAA
TGGAAGAAGCTCTGAATTGGATAAAATATGCAGGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAA
GTATTTTCTTTACTGAATACAAGTACCACATAACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTA
TGGATTGTATAGAGGAAGGAGAACTAATGAAAATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACA
CCAGAGCCATTGAATATAGACCTGAAAACTACCTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCAC
TCGGTGATGGAAAGAGAGCCACTATTCTGAAGAACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAAT
ATGACTGGGCCCTGCAAGCAAACATAAAAGCTCAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAA
AGTTACAAAAACAAATAGAAGACCTACAAGGTCGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTA
GGAGTTTATCAGCACCTATATTTACTACTTCACTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACG
GTGGTAATCAGAATCTAAAGGTGGCGGATGAGGCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGC
CTCCAAAACATAAAGGAAAACAAAAATCTCGAAACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGA
AGAACATCTTGGAGAAACAGTTTTCTAAATCTTCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTC
AAGATGGCTATATGGCCTTATTGGAGCAGCGTTGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAA
TAAAGCAATTGAACCTGGCCATGATTAACTATGTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAAT
TATCTGAAGCCGAAAACCAGTTTAAGAGGATTATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAG
TATATTTGAAAAAAAACAGATTTCTAGAAGCTCTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTT
GGCCCACGAGTAATGTGATTATTGAAGAGTCTCAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTC
CAGTGCCAGATGCCATTTGTTGCTATCAGAAGTGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTA
TACGCATCAGCTGTTGCCAGTACTGTAAAATAGAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTG
ACAAGGATTTTCTACAAGGAATATGTCTTACCCCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTA
AATGTGAATTTGAACACAAGGTCATAAAAGAAAAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGAC
TGAAAGAAGACAAAAAATTGAAGAGAAAGATCCAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAA
GTAATCCACCCAAAAATGAAGAGCAGAAAGAAACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAA
AGCAGTATGCTGACAAGATTAAATCCGGCATACAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAG
ACTATACAACCTGTTTTTCTAGCAGAAATTTTCTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAA
AGACAAGAATATTTCTGCATGTTTTGAGTGAGCTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCT
TAGATGCCACAGGAACTTTCTTTTCTCGTTATGGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAAT
ATGGTCACAAACTAGACTCTATAGAAGGAAAGCAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGC
TGCTAGAAGAACACAGAGACAAGTTCCCAGCATTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAA
GGAAACAAGATAGTGGTGAAGCACCGTTTAGTTCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGT
TAGTTGGGTCTGGAACAACTTCAGTAACTTCAAATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAG
GCCCATTTGCAGTGCCTGACCATCTTCGGCAAGATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCA
ATAAGAAGCTATGGGACATGAACCCAAAACAAAAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTA
CTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACA
TCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCAT
TAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATT
TGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTA
TAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGAC
AGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGG
AAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTT
TTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGAT
GAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGCATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCAT
GTAATTTGCTCATTTGAGTGAGGGCACTTTTTTTGTACATATGATGGGGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGT
ATCCCTATTTCAATGAGCAGTCAGTCTCAAGAGGTTACTGCACTTCAGTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAA
CTCAGCCTGGGCACTTTCTGATAACTGTAAAATGTTTTATAAGATCATGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGA
GCAGCTTAACTACTTTTGTATCTAGCCTTTTTTAAGTATCTTGTTACATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGT
AATATTGAAGAAACAATAGTTTTTATTTATGTAGTTGTACATTTTTAAACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTT
TGACTTAAAGAACTGGAAGTTTATATACACCTGGACTATAAGAAACAGAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAA
ATGGCACTGGCCTGGCCACCTTTTCATTTTACAAATGGGGGAAGTGAAGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAA
TAACTGACAGGTTTTTGTTTTGATGACCTATTAATTATGTAGCCTAGGATTAATATCCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAG
CGTTGGTTCTGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAA
AATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACC

>95071_95071_11_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000520539_length(amino acids)=1160AA_BP=
MRRKWSTASNLCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISV
LQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEE
ALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRA
IEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQ
KQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPK
HKGKQKSRNNESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQ
LNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPT
SNVIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKD
FLQGICLTPDCEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNP
PKNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTR
IFLHVLSELKEVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLE
EHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPF

--------------------------------------------------------------
>95071_95071_12_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000521922_length(transcript)=6682nt_BP=6115nt
TGTATTCTTTAAATATTATGTCTCATTAGTCTCTTCTCTCCTGCTGGAACTTTAACTGGATATATATATACACTAAACTGTTTCCAGATC
ACTTATTCTTTATCTTTCATATTTTTTATCTCTTTGTTTCTCTTTACCAGAATTTACAGTGCTGGATAATTTCATAAGGCATATATTTTA
GTTCACCAATTTTCTCTTCAACTGTGCCTAATATCCTCTGTAACCCATCCTGTCTCTTTTTTTTCTTTTAACAATTGCATTTTTAATTAC
TTTTTTTTTTTTTTTTTAAGATGGAGTCTCTCTCTGTCGCCCAGGCTGGAGTGCAGAGGCGCGATCTCAGCTCACTGCAAGCTCCGCCTC
CCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTTGTATTTT
TAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTCATCTGCTCACGTTGGCCTCCCAGAGTGCTGGG
ATTACAGGCATGAGCCACCATGCCCGGCCGCATTTTTAATTTCTAAAAGTTCTGCCTGGTTCTTTTTTGATATGTCCAGTCATTCTTCAT
GTTCTCATGTTATATGCTGATTTTTGTGACTCTATAGCTATTCTGTAGACTATATCAGACATTCCCAATGTCTGATATCCTTGAGGAGGG
GGATGTCTAAATTTATTGCTTTTTTGTTTTTTTTTCTGTTGTCTCTCCTCAATGTAGCTGTCACCTCATGTGTTTGGTGATCATTGATTA
TGAACTTCTGTTTGATCTTTGTGGTGATCTTGAGAGTCTAATTTGAGGATGCTTGCTTTCTGAAAGCATTTCTATCAGCTTTGTCTGGGA
GCCAGAAAGTTTAGCTGGCATCACTTTTGAGTTCCTACATTTTGCTTCTGGCCCAGGGCTCAGTGTCCTGATCCTATTACTGCTCTTGGC
ACCACTACTTGTAGCACTAAACTGTAGCCAGGTTTAATTTCTAGCTCAAGGTTTGTTGCTTTTGCGTGGAGAGGGTGCCTTCACATGTTC
CCCTATTTCTATGAGCTCAGCAAAAACATCCAAAAAGTGTTTTTTTTTTTAATCTAGGATATACCTTTTTCCTCCCAACAGTACATTCCC
CCAGAGTGTATAGTTGACCATAACTGATGGGATCAGAAGCTCTTTATTTTAATATTTAATTTTAGTAGTATATTTTTGTTTGATTGTATT
ATAAAAAATTTTATGGTACCAAGCAAGCTTTCTTGGTGATACCAACATTTCCATTAAAACTAGTTTACATCTAAGTTAAGATTTGAGTTA
TCCTAAAGAAAAGTATTAAGTAAATAGCAGTACAGATGGCAAATGGATTGCACAATATATCCTCTGGATCCATAGTGACCCTGCAGAGAT
AAACCTGTGATGGTCAAACAATGTGAAAACTGCTGTCAGAGACATGGGCAGGGTGCTCTTGTTTACAGAGAAGAGGTGCAAAAATCAACT
TGATGGTAGTGGGAAGATCAGGAAATGCTTCCTGAAATTGAGTATTAAGAACTAATAGACATTAGGTGGTTGCAGAATAAGTTTTGTTTA
GGAAGGACAAGCAGTTGGGTATGACTGGCTTCTAGGTTGTGTGTTGTGGAGTGACTGGGGATAAAAGCAGGAGCAAGATCACAAAAGGTC
TTCTATGCTTATATTAGGGAAGTTGGACTTTATTCTCAAGCTGAAGGGAAGCTGTTGCATGGTTTTAAGCAGTAAAGTGATATGATCAGA
GTTTTAGAGGATGCCAAGATTGAAGGCAAGTCTGACCAGTTAGGAGACTGCTTGTTAAATTAGTTCAGAGGAGAAACAGTGAAGGCAGTG
GCACTGGGCATGAAGAAGTATATGTGTGCTAATTTTAGATTTCTTAGGGAAGCAGAAATGACAAGAGTTAGTGGTCCATTGGACAGAAAT
ATTGAAGGAGACTGGGGAGTCTAGGTTGACTCCCAGGGTTTAGGTTTGGGCAGTAAAATGACATGTAGAACAATTAACTGATAAACAGCA
TACAGAAAGAGGAAAGAACTTCATTTCATATGTTTGTTTTTGAGGAAAAGATGTTTGTTTTTGAACTTCCTGATTCAGAGGGGCTTGTGG
GACATCTTGGTTAAGATCCTGTAGTAGTTCTAGTAGGGTCTAGAAGTCAAGAGATACAACCCCGCCTGGAAGGATTTGGGAGTCTTCAGC
ATTTGGAATTTTGGAAGCCATTGTTTACTGCAGTGCATATGAGATAATTTAAACTGGTACATAGATAAACACTTGAAAAAATTTTAATAG
ATAGGAATTTAATGTGTATGAGAAACATAACTTGCACATCTAACCTTTGATAATCATGGACATTATCACTTAGGCCAAGTGAGCTCAATA
AAAGGGAAATATTAACTAAAAATATATGTGATACATGGAAATGGCAAAAATCACGGTGAAGCTATGCAAACGATGCAAGTTCAGAAAGTG
CTGTGTTAAGTCATGGGTGTGGTGGATAAATTCACCCAAGGAGAGAGTAAGAGTGAGAAGAAAAGAGAGTTGACATTGGGTGGCGGGGAA
TGGAGAAGAAGAACCCATGAAGGAAACTGAGGAAGAGCAGCCAGACGAATAGGAGGAAAACCAGGAGAAGATGGTCTTTGGAGTCCAAAT
GAAGAGTTCTGAGGAGGAAGTGGTCCACAGCGTCAAACTTGTGCACCATGGACAATTTTGCTGAGGGAGATTTCACTGTGGCGGATTATG
CCTTGTTAGAAGATTGCCCTCACGTGGATGATTGTGTCTTTGCTGCTGAATTTATGAGCAATGATTATGTTCGTGTGACTCAGCTTTACT
GTGATGGGGTGGGTGTGCAATATAAAGATTATATCCAAAGTGAGAGGAATTTGGAATTTGACATCTGCAGTATATGGTGTAGTAAACCAA
TTTCTGTCCTGCAAGATTATTGCGATGCCATTAAAATAAACATCTTCTGGCCACTTCTGTTTCAACATCAAAACAGTTCCGTAATATCAC
GATTGCATCCCTGTGTGGACGCCAACAATTCACGTGCTTCTGAGATAAATTTGAAGAAACTACAACATCTTGAGTTGATGGAAGATATTG
TGGATTTGGCAAAGAAAGTTGCTAATGATTCATTCCTTATTGGAGGCTTATTGAGAATTGGTTGTAAAATAGAAAATAAAATCTTGGCAA
TGGAAGAAGCTCTGAATTGGATAAAATATGCAGGCGATGTAACAATTCTAACTAAATTAGGATCAATTGACAATTGTTGGCCTATGTTAA
GTATTTTCTTTACTGAATACAAGTACCACATAACTAAAATTGTAATGGAAGACTGCAATTTGCTTGAAGAACTTAAAACTCAAAGTTGTA
TGGATTGTATAGAGGAAGGAGAACTAATGAAAATGAAAGGAAATGAAGAGTTTTCCAAAGAAAGATTTGATATAGCTATTATCTATTACA
CCAGAGCCATTGAATATAGACCTGAAAACTACCTTCTTTATGGTAACCGAGCTCTTTGTTTTCTTCGTACTGGACAGTTTAGAAATGCAC
TCGGTGATGGAAAGAGAGCCACTATTCTGAAGAACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAAT
ATGACTGGGCCCTGCAAGCAAACATAAAAGCTCAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAA
AGTTACAAAAACAAATAGAAGACCTACAAGGTCGAACAGCAAATAAGGATCCAATTAAAGCCTTTTATGAAAACAGGGCCTACACACCTA
GGAGTTTATCAGCACCTATATTTACTACTTCACTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACG
GTGGTAATCAGAATCTAAAGGTGGCGGATGAGGCGTTGAAGGTAGATGATTGTGACTGTCATCCTGAATTTTCACCACCATCAAGTCAGC
CTCCAAAACATAAAGGAAAACAAAAATCTCGAAACAATGAATCAGAAAAGTTCAGTTCTAGTTCACCATTGACTTTACCAGCAGATTTGA
AGAACATCTTGGAGAAACAGTTTTCTAAATCTTCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGCTGAGAAGCTTAATTC
AAGATGGCTATATGGCCTTATTGGAGCAGCGTTGCCGCAGCGCTGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAA
TAAAGCAATTGAACCTGGCCATGATTAACTATGTTTTGGTCGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAAT
TATCTGAAGCCGAAAACCAGTTTAAGAGGATTATTGAACACTACCCCAGTGAGGGCCTTGATTGCTTGGCCTACTGTGGAATTGGAAAAG
TATATTTGAAAAAAAACAGATTTCTAGAAGCTCTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTT
GGCCCACGAGTAATGTGATTATTGAAGAGTCTCAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTC
CAGTGCCAGATGCCATTTGTTGCTATCAGAAGTGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTA
TACGCATCAGCTGTTGCCAGTACTGTAAAATAGAATTTCACATGAATTGCTGGAAGAAGTTAAAAACTACAACCTTTAATGATAAAATTG
ACAAGGATTTTCTACAAGGAATATGTCTTACCCCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTGAAGTTA
AATGTGAATTTGAACACAAGGTCATAAAAGAAAAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGAC
TGAAAGAAGACAAAAAATTGAAGAGAAAGATCCAAAAAAAAGAAGCAAAAAAGTTAGCACAAGAAAGAATGGAGGAGGACTTAAGAGAAA
GTAATCCACCCAAAAATGAAGAGCAGAAAGAAACTGTAGACAATGTTCAGCGTTGTCAGTTCCTTGATGACAGAATTCTACAGTGTATAA
AGCAGTATGCTGACAAGATTAAATCCGGCATACAGAATACAGCCATGCTTCTCAAAGAATTGCTTTCTTGGAAAGTTTTGAGCACAGAAG
ACTATACAACCTGTTTTTCTAGCAGAAATTTTCTAAATGAAGCAGTGGACTATGTTATTCGCCACTTGATTCAAGAAAATAACAGAGTAA
AGACAAGAATATTTCTGCATGTTTTGAGTGAGCTTAAAGAAGTGGAGCCCAAATTAGCCGCCTGGATCCAAAAACTTAATAGCTTTGGCT
TAGATGCCACAGGAACTTTCTTTTCTCGTTATGGAGCATCTCTTAAACTGCTTGATTTTAGTATCATGACTTTCCTCTGGAATGAGAAAT
ATGGTCACAAACTAGACTCTATAGAAGGAAAGCAACTTGATTATTTCTCTGAGCCAGCATCATTGAAGGAAGCCCGTTGTTTAATATGGC
TGCTAGAAGAACACAGAGACAAGTTCCCAGCATTGCATAGTGCTTTAGATGAATTCTTTGATATAATGGACAGCCGCTGTACTGTGTTAA
GGAAACAAGATAGTGGTGAAGCACCGTTTAGTTCAACCAAGGTGAAAAACAAAAGCAAGAAAAAGAAGCCAAAGGATTCAAAGCCTATGT
TAGTTGGGTCTGGAACAACTTCAGTAACTTCAAATAATGAGATCATCACTTCAAGTGAAGACCATAGCAATCGAAATTCAGATTCTGCAG
GCCCATTTGCAGTGCCTGACCATCTTCGGCAAGATGTAGAAGAATTCGAAGCTCTCTATGACCAACACAGTAACGAATATGTTGTCCGCA
ATAAGAAGCTATGGGACATGAACCCAAAACAAAAATGTTCAACTCTATATGAAACATTCCACACGTGCAGATGGTTGCCATACAGGTTTA
CTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACA
TCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCAT
TAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATT
TGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAA
TAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATT
TAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAAT

>95071_95071_12_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000521922_length(amino acids)=1160AA_BP=
MRRKWSTASNLCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISV
LQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEE
ALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRA
IEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQ
KQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPK
HKGKQKSRNNESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQ
LNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPT
SNVIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKD
FLQGICLTPDCEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNP
PKNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTR
IFLHVLSELKEVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLE
EHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPF

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Fusion Gene PPI Analysis for TTC3-UBR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTTC3chr21:38538884chr8:103273392ENST00000354749+1451_23002026.0POLG
HgeneTTC3chr21:38538884chr8:103273392ENST00000355666+1461_23002026.0POLG
HgeneTTC3chr21:38538884chr8:103273392ENST00000399017+1461_23002026.0POLG


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTC3-UBR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTC3-UBR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource