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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTC6-KIAA0391 (FusionGDB2 ID:95086)

Fusion Gene Summary for TTC6-KIAA0391

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC6-KIAA0391
Fusion gene ID: 95086
HgeneTgene
Gene symbol

TTC6

KIAA0391

Gene ID

319089

9692

Gene nametetratricopeptide repeat domain 6protein only RNase P catalytic subunit
SynonymsC14orf25|NCRNA00291KIAA0391|MRPP3
Cytomap

14q21.1

14q13.2

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 6TPR repeat protein 6mitochondrial ribonuclease P catalytic subunitmitochondrial RNase P protein 3mitochondrial RNase P subunit 3mitochondrial ribonuclease P protein 3proteinaceous RNase P
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000553443, ENST00000267368, 
ENST00000382320, ENST00000476979, 
ENST00000554555, 		ENST00000603588, 
ENST00000250377, ENST00000321130, 
ENST00000534898, ENST00000557565, 
ENST00000603544, ENST00000604948, 
ENST00000605870, 
Fusion gene scores* DoF score16 X 11 X 5=88010 X 6 X 7=420
# samples 2514
** MAII scorelog2(25/880*10)=-1.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/420*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTC6 [Title/Abstract] AND KIAA0391 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTC6(38075947)-KIAA0391(35735933), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKIAA0391

GO:0097745

mitochondrial tRNA 5'-end processing

25953853


check buttonFusion gene breakpoints across TTC6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIAA0391 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A46G-01ATTC6chr14

38075947

+KIAA0391chr14

35735933

+
ChimerDB4PRADTCGA-EJ-A46G-01ATTC6chr14

38092208

-KIAA0391chr14

35735933

+
ChimerDB4PRADTCGA-EJ-A46GTTC6chr14

38075947

+KIAA0391chr14

35735933

+


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Fusion Gene ORF analysis for TTC6-KIAA0391

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000553443ENST00000603588TTC6chr14

38092208

-KIAA0391chr14

35735933

+
In-frameENST00000553443ENST00000250377TTC6chr14

38092208

-KIAA0391chr14

35735933

+
In-frameENST00000553443ENST00000321130TTC6chr14

38092208

-KIAA0391chr14

35735933

+
In-frameENST00000553443ENST00000534898TTC6chr14

38092208

-KIAA0391chr14

35735933

+
In-frameENST00000553443ENST00000557565TTC6chr14

38092208

-KIAA0391chr14

35735933

+
In-frameENST00000553443ENST00000603544TTC6chr14

38092208

-KIAA0391chr14

35735933

+
In-frameENST00000553443ENST00000604948TTC6chr14

38092208

-KIAA0391chr14

35735933

+
In-frameENST00000553443ENST00000605870TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000250377TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000250377TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000321130TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000321130TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000534898TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000534898TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000557565TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000557565TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000603544TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000603544TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000604948TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000604948TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000605870TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000267368ENST00000605870TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000250377TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000250377TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000321130TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000321130TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000534898TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000534898TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000557565TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000557565TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000603544TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000603544TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000604948TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000604948TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000605870TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000382320ENST00000605870TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000250377TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000250377TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000321130TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000321130TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000534898TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000534898TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000557565TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000557565TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000603544TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000603544TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000604948TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000604948TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000605870TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000476979ENST00000605870TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000553443ENST00000250377TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000553443ENST00000321130TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000553443ENST00000534898TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000553443ENST00000557565TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000553443ENST00000603544TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000553443ENST00000604948TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000553443ENST00000605870TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000250377TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000250377TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000321130TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000321130TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000534898TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000534898TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000557565TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000557565TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000603544TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000603544TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000604948TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000604948TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000605870TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-3CDSENST00000554555ENST00000605870TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-intronENST00000267368ENST00000603588TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-intronENST00000267368ENST00000603588TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-intronENST00000382320ENST00000603588TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-intronENST00000382320ENST00000603588TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-intronENST00000476979ENST00000603588TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-intronENST00000476979ENST00000603588TTC6chr14

38092208

-KIAA0391chr14

35735933

+
intron-intronENST00000553443ENST00000603588TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-intronENST00000554555ENST00000603588TTC6chr14

38075947

+KIAA0391chr14

35735933

+
intron-intronENST00000554555ENST00000603588TTC6chr14

38092208

-KIAA0391chr14

35735933

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000553443TTC6chr1438092208-ENST00000604948KIAA0391chr1435735933+154093901415471
ENST00000553443TTC6chr1438092208-ENST00000557565KIAA0391chr1435735933+314093901415471
ENST00000553443TTC6chr1438092208-ENST00000250377KIAA0391chr1435735933+191293901415471
ENST00000553443TTC6chr1438092208-ENST00000321130KIAA0391chr1435735933+181093901415471
ENST00000553443TTC6chr1438092208-ENST00000534898KIAA0391chr1435735933+191593901415471
ENST00000553443TTC6chr1438092208-ENST00000603544KIAA0391chr1435735933+152093901415471
ENST00000553443TTC6chr1438092208-ENST00000605870KIAA0391chr1435735933+186793901415471

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000553443ENST00000604948TTC6chr1438092208-KIAA0391chr1435735933+0.0511167980.94888324
ENST00000553443ENST00000557565TTC6chr1438092208-KIAA0391chr1435735933+0.0205963250.9794037
ENST00000553443ENST00000250377TTC6chr1438092208-KIAA0391chr1435735933+0.0336744670.9663255
ENST00000553443ENST00000321130TTC6chr1438092208-KIAA0391chr1435735933+0.039598960.9604011
ENST00000553443ENST00000534898TTC6chr1438092208-KIAA0391chr1435735933+0.033457210.96654284
ENST00000553443ENST00000603544TTC6chr1438092208-KIAA0391chr1435735933+0.0501711260.9498288
ENST00000553443ENST00000605870TTC6chr1438092208-KIAA0391chr1435735933+0.0354811740.9645188

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Fusion Genomic Features for TTC6-KIAA0391


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTC6-KIAA0391


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:38075947/chr14:35735933)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKIAA0391chr14:38092208chr14:35735933ENST0000025037748342_578330489.0DomainNote=PRORP
TgeneKIAA0391chr14:38092208chr14:35735933ENST0000060494848342_578330489.0DomainNote=PRORP
TgeneKIAA0391chr14:38092208chr14:35735933ENST0000060587037342_57853212.0DomainNote=PRORP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112101_1380521.0RepeatNote=TPR 2
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112139_1720521.0RepeatNote=TPR 3
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112176_2090521.0RepeatNote=TPR 4
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112210_2430521.0RepeatNote=TPR 5
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112245_2800521.0RepeatNote=TPR 6
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112281_3140521.0RepeatNote=TPR 7
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112320_3470521.0RepeatNote=TPR 8
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112348_3810521.0RepeatNote=TPR 9
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112382_4150521.0RepeatNote=TPR 10
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112416_4490521.0RepeatNote=TPR 11
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112450_4830521.0RepeatNote=TPR 12
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-112484_5170521.0RepeatNote=TPR 13
HgeneTTC6chr14:38092208chr14:35735933ENST00000267368-11257_900521.0RepeatNote=TPR 1
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113101_1380521.0RepeatNote=TPR 2
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113139_1720521.0RepeatNote=TPR 3
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113176_2090521.0RepeatNote=TPR 4
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113210_2430521.0RepeatNote=TPR 5
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113245_2800521.0RepeatNote=TPR 6
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113281_3140521.0RepeatNote=TPR 7
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113320_3470521.0RepeatNote=TPR 8
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113348_3810521.0RepeatNote=TPR 9
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113382_4150521.0RepeatNote=TPR 10
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113416_4490521.0RepeatNote=TPR 11
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113450_4830521.0RepeatNote=TPR 12
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-113484_5170521.0RepeatNote=TPR 13
HgeneTTC6chr14:38092208chr14:35735933ENST00000476979-11357_900521.0RepeatNote=TPR 1
TgeneKIAA0391chr14:38092208chr14:35735933ENST0000032113037342_578409568.0DomainNote=PRORP
TgeneKIAA0391chr14:38092208chr14:35735933ENST0000053489848342_578425584.0DomainNote=PRORP
TgeneKIAA0391chr14:38092208chr14:35735933ENST0000060354437342_578409568.0DomainNote=PRORP


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Fusion Gene Sequence for TTC6-KIAA0391


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95086_95086_1_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000250377_length(transcript)=1912nt_BP=939nt
ATGTCCACAATCCCGAGACACTTTGGCCTGAAATACAAAGAGGAATCGTATATGTTTAAAGAGCTTGAGAAAGTTCGGCAGGAAACTAAA
AAGGATTTTCTCCGATTCAAGCAGAAGTTGGCCTCCAAGCCGGCTGTAGATGAAAGCCCAGTCCACAGCCTCCATGCCCCCGGCCCGGCC
CGCCCCGCGCGCGTTTCCTGCGCCGCAGCCCGGACGTCGAGAAGATACCCTTCGCTTAAAGGCCCTGCGATGTCCGCGGCCGCCCTCCTG
CAGGAGGTGCTCGGAGGCGCGCCGCGTCCCTCGGGCCTGGGTGAGGCGGCGGCTCCAGGCAAGACCCGGTCGTTTCGCCCCCGGGACTTT
TACTTGCGGAGCTCCGCGTTCCTACGGCACCAGGCCCTGAAAAAGCCCCCAGTCATCGCCTCGGGGTTCGGCACGGCCAGACCCGTGGTC
CTGCTGCCTCCGCCCGAGCCACCCGTGAAGCGCAGAGCGCGCGGGGTCTTGGAGAGCTCGCGGCACGCGGCTCCCAGGCGGGTCTTCCAC
TTGGGAAGGGAGCGCGAACAGAGCCAGGAGGTAGCTCCTCTCGCAGGGCCCTGCATGGCCAAAGAGAGGAAGGCCAGCTCCGTCTCCGCA
GAGGACGGCTACATGGAGGCCAGCAGCGGGCGGAGGAAAGTGAGGATCCGCAGCAACTTCGTGAGCGAGAGCGGGGCCCGCGAGGCGCGG
GAAGCGGCGGGGTTAGGAGCCCAGGGAGAACAGGAGAGCTGGCCGCCCAGCGACGCGCGGGAGGCCGCCTGGCAGGCGCTGCTGCCCTCC
CGCGTGATCCCCACGTCCATCGAAGAGATCATCGCCTCTCTGCAGTCCGAGGCCCAGCTGGCCTCCGACCAGACCATCAAAGAGCTCATA
CGGAGCGTCCTTGGCCAGAACTACGACATTACAATGGAACTCTTGAATGTCGTCTCTCAACTAGCCAAACGGAATCTGCGACTGCTGGTC
CTAGGCCGGAAGCACATGCTAAGACGGAGTTCCCAGTGGAGTCGGGATGAGATGGAAGAGGTGCAAAAGCAAGCCAGCTGTTTTTTTGCT
GATGACATCTCGGAGGATGATCCATTCCTTCTGTATGCCACACTGCACTCCGGGAATCACTGCAGGTTTATCACAAGAGACCTGATGCGG
GACCACAAGGCCTGTCTGCCTGATGCCAAGACCCAACGCCTGTTTTTTAAGTGGCAGCAGGGACATCAGCTGGCAATTGTAAATAGGTTT
CCAGGATCAAAACTAACCTTTCAGCGTATTCTCAGCTATGACACAGTGGTGCAAACAACTGGAGACTCGTGGCACATACCATATGATGAA
GACTTGGTAGAAAGATGTTCCTGTGAAGTACCAACCAAATGGCTTTGCCTCCACCAAAAGACATAGAGATTCTTACCTCTATGCTAAGTT
TGTGTTTGGGTACCCTCTAGGTTGGCATCAGAGGCTCTTGAGCTGGTGTTTGTTTAGGGCATTGCCTCTGTCCTGAAGATAAAAGGATTC
TATTAACAGCATTGACATTGATTTTTTAATGAAATGAGATATATCTTTTCATAACCAGCTGCGTTTTTTTCCCCTAACATTTGTTTTTGG
AGGCTTATCAAGAGTTGGAGAACTTAGTGTAGAGCAAAACCTGCATTTCTCCTACTGGGCCAGCTATTCCACTTAGCTTGGGTGACTAAT
AGTGCTTTTGGTATCCATTTTTTGCTACTTCTGACCTTGCCTTCCAGGCCTACCAATAGCAGAATCAATCCATCTGTCCCTGAGATACTC
ATGTTGTTTCAAATGCCTCCTCCCATTTCTGGCATAGTCTCATTCTCTGTATGTTATGCCCTATCCACATGGAATCATTTATCGTCCTCT

>95086_95086_1_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000250377_length(amino acids)=471AA_BP=313
MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPARPARVSCAAARTSRRYPSLKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTRSFRPRDFYLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH
LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAREAAGLGAQGEQESWPPSDAREAAWQALLPS
RVIPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYDITMELLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFA
DDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDE

--------------------------------------------------------------
>95086_95086_2_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000321130_length(transcript)=1810nt_BP=939nt
ATGTCCACAATCCCGAGACACTTTGGCCTGAAATACAAAGAGGAATCGTATATGTTTAAAGAGCTTGAGAAAGTTCGGCAGGAAACTAAA
AAGGATTTTCTCCGATTCAAGCAGAAGTTGGCCTCCAAGCCGGCTGTAGATGAAAGCCCAGTCCACAGCCTCCATGCCCCCGGCCCGGCC
CGCCCCGCGCGCGTTTCCTGCGCCGCAGCCCGGACGTCGAGAAGATACCCTTCGCTTAAAGGCCCTGCGATGTCCGCGGCCGCCCTCCTG
CAGGAGGTGCTCGGAGGCGCGCCGCGTCCCTCGGGCCTGGGTGAGGCGGCGGCTCCAGGCAAGACCCGGTCGTTTCGCCCCCGGGACTTT
TACTTGCGGAGCTCCGCGTTCCTACGGCACCAGGCCCTGAAAAAGCCCCCAGTCATCGCCTCGGGGTTCGGCACGGCCAGACCCGTGGTC
CTGCTGCCTCCGCCCGAGCCACCCGTGAAGCGCAGAGCGCGCGGGGTCTTGGAGAGCTCGCGGCACGCGGCTCCCAGGCGGGTCTTCCAC
TTGGGAAGGGAGCGCGAACAGAGCCAGGAGGTAGCTCCTCTCGCAGGGCCCTGCATGGCCAAAGAGAGGAAGGCCAGCTCCGTCTCCGCA
GAGGACGGCTACATGGAGGCCAGCAGCGGGCGGAGGAAAGTGAGGATCCGCAGCAACTTCGTGAGCGAGAGCGGGGCCCGCGAGGCGCGG
GAAGCGGCGGGGTTAGGAGCCCAGGGAGAACAGGAGAGCTGGCCGCCCAGCGACGCGCGGGAGGCCGCCTGGCAGGCGCTGCTGCCCTCC
CGCGTGATCCCCACGTCCATCGAAGAGATCATCGCCTCTCTGCAGTCCGAGGCCCAGCTGGCCTCCGACCAGACCATCAAAGAGCTCATA
CGGAGCGTCCTTGGCCAGAACTACGACATTACAATGGAACTCTTGAATGTCGTCTCTCAACTAGCCAAACGGAATCTGCGACTGCTGGTC
CTAGGCCGGAAGCACATGCTAAGACGGAGTTCCCAGTGGAGTCGGGATGAGATGGAAGAGGTGCAAAAGCAAGCCAGCTGTTTTTTTGCT
GATGACATCTCGGAGGATGATCCATTCCTTCTGTATGCCACACTGCACTCCGGGAATCACTGCAGGTTTATCACAAGAGACCTGATGCGG
GACCACAAGGCCTGTCTGCCTGATGCCAAGACCCAACGCCTGTTTTTTAAGTGGCAGCAGGGACATCAGCTGGCAATTGTAAATAGGTTT
CCAGGATCAAAACTAACCTTTCAGCGTATTCTCAGCTATGACACAGTGGTGCAAACAACTGGAGACTCGTGGCACATACCATATGATGAA
GACTTGGTAGAAAGATGTTCCTGTGAAGTACCAACCAAATGGCTTTGCCTCCACCAAAAGACATAGAGATTCTTACCTCTATGCTAAGTT
TGTGTTTGGGTACCCTCTAGGTTGGCATCAGAGGCTCTTGAGCTGGTGTTTGTTTAGGGCATTGCCTCTGTCCTGAAGATAAAAGGATTC
TATTAACAGCATTGACATTGATTTTTTAATGAAATGAGATATATCTTTTCATAACCAGCTGCGTTTTTTTCCCCTAACATTTGTTTTTGG
AGGCTTATCAAGAGTTGGAGAACTTAGTGTAGAGCAAAACCTGCATTTCTCCTACTGGGCCAGCTATTCCACTTAGCTTGGGTGACTAAT
AGTGCTTTTGGTATCCATTTTTTGCTACTTCTGACCTTGCCTTCCAGGCCTACCAATAGCAGAATCAATCCATCTGTCCCTGAGATACTC

>95086_95086_2_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000321130_length(amino acids)=471AA_BP=313
MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPARPARVSCAAARTSRRYPSLKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTRSFRPRDFYLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH
LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAREAAGLGAQGEQESWPPSDAREAAWQALLPS
RVIPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYDITMELLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFA
DDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDE

--------------------------------------------------------------
>95086_95086_3_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000534898_length(transcript)=1915nt_BP=939nt
ATGTCCACAATCCCGAGACACTTTGGCCTGAAATACAAAGAGGAATCGTATATGTTTAAAGAGCTTGAGAAAGTTCGGCAGGAAACTAAA
AAGGATTTTCTCCGATTCAAGCAGAAGTTGGCCTCCAAGCCGGCTGTAGATGAAAGCCCAGTCCACAGCCTCCATGCCCCCGGCCCGGCC
CGCCCCGCGCGCGTTTCCTGCGCCGCAGCCCGGACGTCGAGAAGATACCCTTCGCTTAAAGGCCCTGCGATGTCCGCGGCCGCCCTCCTG
CAGGAGGTGCTCGGAGGCGCGCCGCGTCCCTCGGGCCTGGGTGAGGCGGCGGCTCCAGGCAAGACCCGGTCGTTTCGCCCCCGGGACTTT
TACTTGCGGAGCTCCGCGTTCCTACGGCACCAGGCCCTGAAAAAGCCCCCAGTCATCGCCTCGGGGTTCGGCACGGCCAGACCCGTGGTC
CTGCTGCCTCCGCCCGAGCCACCCGTGAAGCGCAGAGCGCGCGGGGTCTTGGAGAGCTCGCGGCACGCGGCTCCCAGGCGGGTCTTCCAC
TTGGGAAGGGAGCGCGAACAGAGCCAGGAGGTAGCTCCTCTCGCAGGGCCCTGCATGGCCAAAGAGAGGAAGGCCAGCTCCGTCTCCGCA
GAGGACGGCTACATGGAGGCCAGCAGCGGGCGGAGGAAAGTGAGGATCCGCAGCAACTTCGTGAGCGAGAGCGGGGCCCGCGAGGCGCGG
GAAGCGGCGGGGTTAGGAGCCCAGGGAGAACAGGAGAGCTGGCCGCCCAGCGACGCGCGGGAGGCCGCCTGGCAGGCGCTGCTGCCCTCC
CGCGTGATCCCCACGTCCATCGAAGAGATCATCGCCTCTCTGCAGTCCGAGGCCCAGCTGGCCTCCGACCAGACCATCAAAGAGCTCATA
CGGAGCGTCCTTGGCCAGAACTACGACATTACAATGGAACTCTTGAATGTCGTCTCTCAACTAGCCAAACGGAATCTGCGACTGCTGGTC
CTAGGCCGGAAGCACATGCTAAGACGGAGTTCCCAGTGGAGTCGGGATGAGATGGAAGAGGTGCAAAAGCAAGCCAGCTGTTTTTTTGCT
GATGACATCTCGGAGGATGATCCATTCCTTCTGTATGCCACACTGCACTCCGGGAATCACTGCAGGTTTATCACAAGAGACCTGATGCGG
GACCACAAGGCCTGTCTGCCTGATGCCAAGACCCAACGCCTGTTTTTTAAGTGGCAGCAGGGACATCAGCTGGCAATTGTAAATAGGTTT
CCAGGATCAAAACTAACCTTTCAGCGTATTCTCAGCTATGACACAGTGGTGCAAACAACTGGAGACTCGTGGCACATACCATATGATGAA
GACTTGGTAGAAAGATGTTCCTGTGAAGTACCAACCAAATGGCTTTGCCTCCACCAAAAGACATAGAGATTCTTACCTCTATGCTAAGTT
TGTGTTTGGGTACCCTCTAGGTTGGCATCAGAGGCTCTTGAGCTGGTGTTTGTTTAGGGCATTGCCTCTGTCCTGAAGATAAAAGGATTC
TATTAACAGCATTGACATTGATTTTTTAATGAAATGAGATATATCTTTTCATAACCAGCTGCGTTTTTTTCCCCTAACATTTGTTTTTGG
AGGCTTATCAAGAGTTGGAGAACTTAGTGTAGAGCAAAACCTGCATTTCTCCTACTGGGCCAGCTATTCCACTTAGCTTGGGTGACTAAT
AGTGCTTTTGGTATCCATTTTTTGCTACTTCTGACCTTGCCTTCCAGGCCTACCAATAGCAGAATCAATCCATCTGTCCCTGAGATACTC
ATGTTGTTTCAAATGCCTCCTCCCATTTCTGGCATAGTCTCATTCTCTGTATGTTATGCCCTATCCACATGGAATCATTTATCGTCCTCT

>95086_95086_3_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000534898_length(amino acids)=471AA_BP=313
MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPARPARVSCAAARTSRRYPSLKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTRSFRPRDFYLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH
LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAREAAGLGAQGEQESWPPSDAREAAWQALLPS
RVIPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYDITMELLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFA
DDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDE

--------------------------------------------------------------
>95086_95086_4_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000557565_length(transcript)=3140nt_BP=939nt
ATGTCCACAATCCCGAGACACTTTGGCCTGAAATACAAAGAGGAATCGTATATGTTTAAAGAGCTTGAGAAAGTTCGGCAGGAAACTAAA
AAGGATTTTCTCCGATTCAAGCAGAAGTTGGCCTCCAAGCCGGCTGTAGATGAAAGCCCAGTCCACAGCCTCCATGCCCCCGGCCCGGCC
CGCCCCGCGCGCGTTTCCTGCGCCGCAGCCCGGACGTCGAGAAGATACCCTTCGCTTAAAGGCCCTGCGATGTCCGCGGCCGCCCTCCTG
CAGGAGGTGCTCGGAGGCGCGCCGCGTCCCTCGGGCCTGGGTGAGGCGGCGGCTCCAGGCAAGACCCGGTCGTTTCGCCCCCGGGACTTT
TACTTGCGGAGCTCCGCGTTCCTACGGCACCAGGCCCTGAAAAAGCCCCCAGTCATCGCCTCGGGGTTCGGCACGGCCAGACCCGTGGTC
CTGCTGCCTCCGCCCGAGCCACCCGTGAAGCGCAGAGCGCGCGGGGTCTTGGAGAGCTCGCGGCACGCGGCTCCCAGGCGGGTCTTCCAC
TTGGGAAGGGAGCGCGAACAGAGCCAGGAGGTAGCTCCTCTCGCAGGGCCCTGCATGGCCAAAGAGAGGAAGGCCAGCTCCGTCTCCGCA
GAGGACGGCTACATGGAGGCCAGCAGCGGGCGGAGGAAAGTGAGGATCCGCAGCAACTTCGTGAGCGAGAGCGGGGCCCGCGAGGCGCGG
GAAGCGGCGGGGTTAGGAGCCCAGGGAGAACAGGAGAGCTGGCCGCCCAGCGACGCGCGGGAGGCCGCCTGGCAGGCGCTGCTGCCCTCC
CGCGTGATCCCCACGTCCATCGAAGAGATCATCGCCTCTCTGCAGTCCGAGGCCCAGCTGGCCTCCGACCAGACCATCAAAGAGCTCATA
CGGAGCGTCCTTGGCCAGAACTACGACATTACAATGGAACTCTTGAATGTCGTCTCTCAACTAGCCAAACGGAATCTGCGACTGCTGGTC
CTAGGCCGGAAGCACATGCTAAGACGGAGTTCCCAGTGGAGTCGGGATGAGATGGAAGAGGTGCAAAAGCAAGCCAGCTGTTTTTTTGCT
GATGACATCTCGGAGGATGATCCATTCCTTCTGTATGCCACACTGCACTCCGGGAATCACTGCAGGTTTATCACAAGAGACCTGATGCGG
GACCACAAGGCCTGTCTGCCTGATGCCAAGACCCAACGCCTGTTTTTTAAGTGGCAGCAGGGACATCAGCTGGCAATTGTAAATAGGTTT
CCAGGATCAAAACTAACCTTTCAGCGTATTCTCAGCTATGACACAGTGGTGCAAACAACTGGAGACTCGTGGCACATACCATATGATGAA
GACTTGGTAGAAAGATGTTCCTGTGAAGTACCAACCAAATGGCTTTGCCTCCACCAAAAGACATAGAGATTCTTACCTCTATGCTAAGTT
TGTGTTTGGGTACCCTCTAGGTTGGCATCAGAGGCTCTTGAGCTGGTGTTTGTTTAGGGCATTGCCTCTGTCCTGAAGATAAAAGGATTC
TATTAACAGCATTGACATTGATTTTTTAATGAAATGAGATATATCTTTTCATAACCAGCTGCGTTTTTTTCCCCTAACATTTGTTTTTGG
AGGCTTATCAAGAGTTGGAGAACTTAGTGTAGAGCAAAACCTGCATTTCTCCTACTGGGCCAGCTATTCCACTTAGCTTGGGTGACTAAT
AGTGCTTTTGGTATCCATTTTTTGCTACTTCTGACCTTGCCTTCCAGGCCTACCAATAGCAGAATCAATCCATCTGTCCCTGAGATACTC
ATGTTGTTTCAAATGCCTCCTCCCATTTCTGGCATAGTCTCATTCTCTGTATGTTATGCCCTATCCACATGGAATCATTTATCGTCCTCT
GTAATAAACTGGCCAAGATACTAAAGGCTTACTATTCATAGCAGTTTTTAATTACTTATCATCCAATTATTTGGATTGGAGAAGAGGGGG
CATTCACTCCTCTTTTTCTTATTTTTTTTGGAAATAGAGTCTCAACTTACTCTGTCGCCAGGGCTGGAGTGCAGTGACGTGATCACAGTT
CACTGCAGCCTCAAACTCCCAGGCTCAAGCAATCTTCCTACCTCAGCCCTCCTGAGTAATTGGGACTACAGAACAGAGAATGTCAGTATC
CAATAGGATGCCAGTGGAATTCCCTGACGATTCCATCCATGCGGCTCTGCTGGAGCAGGGTAGTGTCCTAGGCTGGGAGAATGGGATGGA
GCCTCCACCTCATGAAGTAGCTTCCTTTGGAGGTGGCTATGGCAGGTCTTCGGAGAGAATATGCTTTTAAGGCTATTAACCAGGGTGGCC
TTACATCAGTAGCTGTCAGAGGGAAAGACTGTGCAGTAATTGTCACACAGAAGAAAGTACCTGACAAATTATTGGATTCCAGCACAGTGA
CTCACTTATTCAAGATAACTGAAAACATTGGTTGTGTGATGACCGGAATGACAGCTGACAGCAGATCCCAGGTACAGAGGGCACGCTATG
AGGCAGCTAACTGGAAATACAAGTATGGCTATGAGATTCCTGTGGACATGCTGTGTAAAAGAATTGCCGATATTTCTCAGGTCTACACAC
AGAATGCTGAAATGAGGCCTCTTGGTTGTTGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTG
CAGGTTACTACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAAT
TTGATTGGACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAG
TTGGAGTAGTGACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACT
AAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGA

>95086_95086_4_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000557565_length(amino acids)=471AA_BP=313
MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPARPARVSCAAARTSRRYPSLKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTRSFRPRDFYLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH
LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAREAAGLGAQGEQESWPPSDAREAAWQALLPS
RVIPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYDITMELLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFA
DDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDE

--------------------------------------------------------------
>95086_95086_5_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000603544_length(transcript)=1520nt_BP=939nt
ATGTCCACAATCCCGAGACACTTTGGCCTGAAATACAAAGAGGAATCGTATATGTTTAAAGAGCTTGAGAAAGTTCGGCAGGAAACTAAA
AAGGATTTTCTCCGATTCAAGCAGAAGTTGGCCTCCAAGCCGGCTGTAGATGAAAGCCCAGTCCACAGCCTCCATGCCCCCGGCCCGGCC
CGCCCCGCGCGCGTTTCCTGCGCCGCAGCCCGGACGTCGAGAAGATACCCTTCGCTTAAAGGCCCTGCGATGTCCGCGGCCGCCCTCCTG
CAGGAGGTGCTCGGAGGCGCGCCGCGTCCCTCGGGCCTGGGTGAGGCGGCGGCTCCAGGCAAGACCCGGTCGTTTCGCCCCCGGGACTTT
TACTTGCGGAGCTCCGCGTTCCTACGGCACCAGGCCCTGAAAAAGCCCCCAGTCATCGCCTCGGGGTTCGGCACGGCCAGACCCGTGGTC
CTGCTGCCTCCGCCCGAGCCACCCGTGAAGCGCAGAGCGCGCGGGGTCTTGGAGAGCTCGCGGCACGCGGCTCCCAGGCGGGTCTTCCAC
TTGGGAAGGGAGCGCGAACAGAGCCAGGAGGTAGCTCCTCTCGCAGGGCCCTGCATGGCCAAAGAGAGGAAGGCCAGCTCCGTCTCCGCA
GAGGACGGCTACATGGAGGCCAGCAGCGGGCGGAGGAAAGTGAGGATCCGCAGCAACTTCGTGAGCGAGAGCGGGGCCCGCGAGGCGCGG
GAAGCGGCGGGGTTAGGAGCCCAGGGAGAACAGGAGAGCTGGCCGCCCAGCGACGCGCGGGAGGCCGCCTGGCAGGCGCTGCTGCCCTCC
CGCGTGATCCCCACGTCCATCGAAGAGATCATCGCCTCTCTGCAGTCCGAGGCCCAGCTGGCCTCCGACCAGACCATCAAAGAGCTCATA
CGGAGCGTCCTTGGCCAGAACTACGACATTACAATGGAACTCTTGAATGTCGTCTCTCAACTAGCCAAACGGAATCTGCGACTGCTGGTC
CTAGGCCGGAAGCACATGCTAAGACGGAGTTCCCAGTGGAGTCGGGATGAGATGGAAGAGGTGCAAAAGCAAGCCAGCTGTTTTTTTGCT
GATGACATCTCGGAGGATGATCCATTCCTTCTGTATGCCACACTGCACTCCGGGAATCACTGCAGGTTTATCACAAGAGACCTGATGCGG
GACCACAAGGCCTGTCTGCCTGATGCCAAGACCCAACGCCTGTTTTTTAAGTGGCAGCAGGGACATCAGCTGGCAATTGTAAATAGGTTT
CCAGGATCAAAACTAACCTTTCAGCGTATTCTCAGCTATGACACAGTGGTGCAAACAACTGGAGACTCGTGGCACATACCATATGATGAA
GACTTGGTAGAAAGATGTTCCTGTGAAGTACCAACCAAATGGCTTTGCCTCCACCAAAAGACATAGAGATTCTTACCTCTATGCTAAGTT

>95086_95086_5_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000603544_length(amino acids)=471AA_BP=313
MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPARPARVSCAAARTSRRYPSLKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTRSFRPRDFYLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH
LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAREAAGLGAQGEQESWPPSDAREAAWQALLPS
RVIPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYDITMELLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFA
DDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDE

--------------------------------------------------------------
>95086_95086_6_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000604948_length(transcript)=1540nt_BP=939nt
ATGTCCACAATCCCGAGACACTTTGGCCTGAAATACAAAGAGGAATCGTATATGTTTAAAGAGCTTGAGAAAGTTCGGCAGGAAACTAAA
AAGGATTTTCTCCGATTCAAGCAGAAGTTGGCCTCCAAGCCGGCTGTAGATGAAAGCCCAGTCCACAGCCTCCATGCCCCCGGCCCGGCC
CGCCCCGCGCGCGTTTCCTGCGCCGCAGCCCGGACGTCGAGAAGATACCCTTCGCTTAAAGGCCCTGCGATGTCCGCGGCCGCCCTCCTG
CAGGAGGTGCTCGGAGGCGCGCCGCGTCCCTCGGGCCTGGGTGAGGCGGCGGCTCCAGGCAAGACCCGGTCGTTTCGCCCCCGGGACTTT
TACTTGCGGAGCTCCGCGTTCCTACGGCACCAGGCCCTGAAAAAGCCCCCAGTCATCGCCTCGGGGTTCGGCACGGCCAGACCCGTGGTC
CTGCTGCCTCCGCCCGAGCCACCCGTGAAGCGCAGAGCGCGCGGGGTCTTGGAGAGCTCGCGGCACGCGGCTCCCAGGCGGGTCTTCCAC
TTGGGAAGGGAGCGCGAACAGAGCCAGGAGGTAGCTCCTCTCGCAGGGCCCTGCATGGCCAAAGAGAGGAAGGCCAGCTCCGTCTCCGCA
GAGGACGGCTACATGGAGGCCAGCAGCGGGCGGAGGAAAGTGAGGATCCGCAGCAACTTCGTGAGCGAGAGCGGGGCCCGCGAGGCGCGG
GAAGCGGCGGGGTTAGGAGCCCAGGGAGAACAGGAGAGCTGGCCGCCCAGCGACGCGCGGGAGGCCGCCTGGCAGGCGCTGCTGCCCTCC
CGCGTGATCCCCACGTCCATCGAAGAGATCATCGCCTCTCTGCAGTCCGAGGCCCAGCTGGCCTCCGACCAGACCATCAAAGAGCTCATA
CGGAGCGTCCTTGGCCAGAACTACGACATTACAATGGAACTCTTGAATGTCGTCTCTCAACTAGCCAAACGGAATCTGCGACTGCTGGTC
CTAGGCCGGAAGCACATGCTAAGACGGAGTTCCCAGTGGAGTCGGGATGAGATGGAAGAGGTGCAAAAGCAAGCCAGCTGTTTTTTTGCT
GATGACATCTCGGAGGATGATCCATTCCTTCTGTATGCCACACTGCACTCCGGGAATCACTGCAGGTTTATCACAAGAGACCTGATGCGG
GACCACAAGGCCTGTCTGCCTGATGCCAAGACCCAACGCCTGTTTTTTAAGTGGCAGCAGGGACATCAGCTGGCAATTGTAAATAGGTTT
CCAGGATCAAAACTAACCTTTCAGCGTATTCTCAGCTATGACACAGTGGTGCAAACAACTGGAGACTCGTGGCACATACCATATGATGAA
GACTTGGTAGAAAGATGTTCCTGTGAAGTACCAACCAAATGGCTTTGCCTCCACCAAAAGACATAGAGATTCTTACCTCTATGCTAAGTT
TGTGTTTGGGTACCCTCTAGGTTGGCATCAGAGGCTCTTGAGCTGGTGTTTGTTTAGGGCATTGCCTCTGTCCTGAAGATAAAAGGATTC

>95086_95086_6_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000604948_length(amino acids)=471AA_BP=313
MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPARPARVSCAAARTSRRYPSLKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTRSFRPRDFYLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH
LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAREAAGLGAQGEQESWPPSDAREAAWQALLPS
RVIPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYDITMELLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFA
DDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDE

--------------------------------------------------------------
>95086_95086_7_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000605870_length(transcript)=1867nt_BP=939nt
ATGTCCACAATCCCGAGACACTTTGGCCTGAAATACAAAGAGGAATCGTATATGTTTAAAGAGCTTGAGAAAGTTCGGCAGGAAACTAAA
AAGGATTTTCTCCGATTCAAGCAGAAGTTGGCCTCCAAGCCGGCTGTAGATGAAAGCCCAGTCCACAGCCTCCATGCCCCCGGCCCGGCC
CGCCCCGCGCGCGTTTCCTGCGCCGCAGCCCGGACGTCGAGAAGATACCCTTCGCTTAAAGGCCCTGCGATGTCCGCGGCCGCCCTCCTG
CAGGAGGTGCTCGGAGGCGCGCCGCGTCCCTCGGGCCTGGGTGAGGCGGCGGCTCCAGGCAAGACCCGGTCGTTTCGCCCCCGGGACTTT
TACTTGCGGAGCTCCGCGTTCCTACGGCACCAGGCCCTGAAAAAGCCCCCAGTCATCGCCTCGGGGTTCGGCACGGCCAGACCCGTGGTC
CTGCTGCCTCCGCCCGAGCCACCCGTGAAGCGCAGAGCGCGCGGGGTCTTGGAGAGCTCGCGGCACGCGGCTCCCAGGCGGGTCTTCCAC
TTGGGAAGGGAGCGCGAACAGAGCCAGGAGGTAGCTCCTCTCGCAGGGCCCTGCATGGCCAAAGAGAGGAAGGCCAGCTCCGTCTCCGCA
GAGGACGGCTACATGGAGGCCAGCAGCGGGCGGAGGAAAGTGAGGATCCGCAGCAACTTCGTGAGCGAGAGCGGGGCCCGCGAGGCGCGG
GAAGCGGCGGGGTTAGGAGCCCAGGGAGAACAGGAGAGCTGGCCGCCCAGCGACGCGCGGGAGGCCGCCTGGCAGGCGCTGCTGCCCTCC
CGCGTGATCCCCACGTCCATCGAAGAGATCATCGCCTCTCTGCAGTCCGAGGCCCAGCTGGCCTCCGACCAGACCATCAAAGAGCTCATA
CGGAGCGTCCTTGGCCAGAACTACGACATTACAATGGAACTCTTGAATGTCGTCTCTCAACTAGCCAAACGGAATCTGCGACTGCTGGTC
CTAGGCCGGAAGCACATGCTAAGACGGAGTTCCCAGTGGAGTCGGGATGAGATGGAAGAGGTGCAAAAGCAAGCCAGCTGTTTTTTTGCT
GATGACATCTCGGAGGATGATCCATTCCTTCTGTATGCCACACTGCACTCCGGGAATCACTGCAGGTTTATCACAAGAGACCTGATGCGG
GACCACAAGGCCTGTCTGCCTGATGCCAAGACCCAACGCCTGTTTTTTAAGTGGCAGCAGGGACATCAGCTGGCAATTGTAAATAGGTTT
CCAGGATCAAAACTAACCTTTCAGCGTATTCTCAGCTATGACACAGTGGTGCAAACAACTGGAGACTCGTGGCACATACCATATGATGAA
GACTTGGTAGAAAGATGTTCCTGTGAAGTACCAACCAAATGGCTTTGCCTCCACCAAAAGACATAGAGATTCTTACCTCTATGCTAAGTT
TGTGTTTGGGTACCCTCTAGGTTGGCATCAGAGGCTCTTGAGCTGGTGTTTGTTTAGGGCATTGCCTCTGTCCTGAAGATAAAAGGATTC
TATTAACAGCATTGACATTGATTTTTTAATGAAATGAGATATATCTTTTCATAACCAGCTGCGTTTTTTTCCCCTAACATTTGTTTTTGG
AGGCTTATCAAGAGTTGGAGAACTTAGTGTAGAGCAAAACCTGCATTTCTCCTACTGGGCCAGCTATTCCACTTAGCTTGGGTGACTAAT
AGTGCTTTTGGTATCCATTTTTTGCTACTTCTGACCTTGCCTTCCAGGCCTACCAATAGCAGAATCAATCCATCTGTCCCTGAGATACTC

>95086_95086_7_TTC6-KIAA0391_TTC6_chr14_38092208_ENST00000553443_KIAA0391_chr14_35735933_ENST00000605870_length(amino acids)=471AA_BP=313
MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPARPARVSCAAARTSRRYPSLKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTRSFRPRDFYLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH
LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAREAAGLGAQGEQESWPPSDAREAAWQALLPS
RVIPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYDITMELLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFA
DDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDE

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Fusion Gene PPI Analysis for TTC6-KIAA0391


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTC6-KIAA0391


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTC6-KIAA0391


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource