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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTC7B-PPP1R21 (FusionGDB2 ID:95110)

Fusion Gene Summary for TTC7B-PPP1R21

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC7B-PPP1R21
Fusion gene ID: 95110
HgeneTgene
Gene symbol

TTC7B

PPP1R21

Gene ID

145567

129285

Gene nametetratricopeptide repeat domain 7Bprotein phosphatase 1 regulatory subunit 21
SynonymsTTC7L1|c14_5685CCDC128|KLRAQ1
Cytomap

14q32.11

2p16.3

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 7BTPR repeat protein 7-like-1TPR repeat protein 7Btetratricopeptide repeat domain 7 like 1tetratricopeptide repeat protein 7-like-1protein phosphatase 1 regulatory subunit 21KLRAQ motif containing 1KLRAQ motif-containing protein 1coiled-coil domain containing 128coiled-coil domain-containing protein 128
Modification date2020031320200313
UniProtAcc.

Q6ZMI0

Ensembl transtripts involved in fusion geneENST00000328459, ENST00000357056, 
ENST00000554654, 		ENST00000476199, 
ENST00000281394, ENST00000294952, 
ENST00000449090, 
Fusion gene scores* DoF score17 X 17 X 10=28904 X 4 X 3=48
# samples 194
** MAII scorelog2(19/2890*10)=-3.92699816905709
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTC7B [Title/Abstract] AND PPP1R21 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R21(48737252)-TTC7B(91124731), # samples:2
TTC7B(91142867)-PPP1R21(48734408), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTC7B

GO:0046854

phosphatidylinositol phosphorylation

23229899|26571211

HgeneTTC7B

GO:0072659

protein localization to plasma membrane

23229899|26571211


check buttonFusion gene breakpoints across TTC7B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP1R21 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0905-01BTTC7Bchr14

91142867

-PPP1R21chr2

48734408

+


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Fusion Gene ORF analysis for TTC7B-PPP1R21

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000328459ENST00000476199TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
5CDS-3UTRENST00000357056ENST00000476199TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
In-frameENST00000328459ENST00000281394TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
In-frameENST00000328459ENST00000294952TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
In-frameENST00000328459ENST00000449090TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
In-frameENST00000357056ENST00000281394TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
In-frameENST00000357056ENST00000294952TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
In-frameENST00000357056ENST00000449090TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
intron-3CDSENST00000554654ENST00000281394TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
intron-3CDSENST00000554654ENST00000294952TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
intron-3CDSENST00000554654ENST00000449090TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+
intron-3UTRENST00000554654ENST00000476199TTC7Bchr14

91142867

-PPP1R21chr2

48734408

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357056TTC7Bchr1491142867-ENST00000281394PPP1R21chr248734408+229112741221648508
ENST00000357056TTC7Bchr1491142867-ENST00000294952PPP1R21chr248734408+229112741221648508
ENST00000357056TTC7Bchr1491142867-ENST00000449090PPP1R21chr248734408+171312741221648508
ENST00000328459TTC7Bchr1491142867-ENST00000281394PPP1R21chr248734408+229112741221648508
ENST00000328459TTC7Bchr1491142867-ENST00000294952PPP1R21chr248734408+229112741221648508
ENST00000328459TTC7Bchr1491142867-ENST00000449090PPP1R21chr248734408+171312741221648508

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357056ENST00000281394TTC7Bchr1491142867-PPP1R21chr248734408+0.0021640440.99783593
ENST00000357056ENST00000294952TTC7Bchr1491142867-PPP1R21chr248734408+0.0021640440.99783593
ENST00000357056ENST00000449090TTC7Bchr1491142867-PPP1R21chr248734408+0.0089934110.99100655
ENST00000328459ENST00000281394TTC7Bchr1491142867-PPP1R21chr248734408+0.0021640440.99783593
ENST00000328459ENST00000294952TTC7Bchr1491142867-PPP1R21chr248734408+0.0021640440.99783593
ENST00000328459ENST00000449090TTC7Bchr1491142867-PPP1R21chr248734408+0.0089934110.99100655

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Fusion Genomic Features for TTC7B-PPP1R21


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TTC7Bchr1491142866-PPP1R21chr248734407+9.63E-050.9999037
TTC7Bchr1491142866-PPP1R21chr248734407+9.63E-050.9999037

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TTC7B-PPP1R21


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:48737252/chr2:91124731)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PPP1R21

Q6ZMI0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (PubMed:30520571). {ECO:0000269|PubMed:30520571, ECO:0000305|PubMed:19389623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920329_333384844.0Compositional biasNote=Poly-Leu
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921329_333384861.0Compositional biasNote=Poly-Leu
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920219_252384844.0RepeatNote=TPR 2
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-92097_131384844.0RepeatNote=TPR 1
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921219_252384861.0RepeatNote=TPR 2
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-92197_131384861.0RepeatNote=TPR 1
TgenePPP1R21chr14:91142867chr2:48734408ENST000002813941621693_742645770.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R21chr14:91142867chr2:48734408ENST000002949521722693_742656781.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R21chr14:91142867chr2:48734408ENST000004490901520693_742614739.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920363_396384844.0RepeatNote=TPR 3
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920397_430384844.0RepeatNote=TPR 4
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920479_514384844.0RepeatNote=TPR 5
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920516_548384844.0RepeatNote=TPR 6
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920549_582384844.0RepeatNote=TPR 7
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920696_729384844.0RepeatNote=TPR 8
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920730_763384844.0RepeatNote=TPR 9
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920765_797384844.0RepeatNote=TPR 10
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000328459-920798_831384844.0RepeatNote=TPR 11
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921363_396384861.0RepeatNote=TPR 3
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921397_430384861.0RepeatNote=TPR 4
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921479_514384861.0RepeatNote=TPR 5
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921516_548384861.0RepeatNote=TPR 6
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921549_582384861.0RepeatNote=TPR 7
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921696_729384861.0RepeatNote=TPR 8
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921730_763384861.0RepeatNote=TPR 9
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921765_797384861.0RepeatNote=TPR 10
HgeneTTC7Bchr14:91142867chr2:48734408ENST00000357056-921798_831384861.0RepeatNote=TPR 11
TgenePPP1R21chr14:91142867chr2:48734408ENST0000028139416211_207645770.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R21chr14:91142867chr2:48734408ENST000002813941621556_607645770.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R21chr14:91142867chr2:48734408ENST0000029495217221_207656781.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R21chr14:91142867chr2:48734408ENST000002949521722556_607656781.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R21chr14:91142867chr2:48734408ENST0000044909015201_207614739.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R21chr14:91142867chr2:48734408ENST000004490901520556_607614739.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for TTC7B-PPP1R21


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95110_95110_1_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000328459_PPP1R21_chr2_48734408_ENST00000281394_length(transcript)=2291nt_BP=1274nt
GTTACGCCGCGGAGCCGGGAGCCGGAGCCCGAGCCCGCGGCGGCGGCGGGAGGCGGCGAGGGGGCGCCGCGGCGGCGGCGGTGGGGCCTG
CGGGGCGGGCGGCCGGGCCCGGCCAGGCCGCGATGGCGACCAAGAAGGCAGGCTCGCGGCTGGAGACGGAGATCGAGCGCTGCCGCTCCG
AGTGCCAGTGGGAGCGGATCCCTGAGCTCGTCAAGCAGCTGTCGGCCAAGCTCATCGCCAACGATGACATGGCAGAGCTTCTCCTCGGGG
AGTCGAAGCTGGAGCAGTACCTGAAGGAACACCCCCTGAGGCAGGGGGCCAGTCCCCGAGGCCCCAAGCCCCAGCTGACTGAGGTCCGCA
AGCATCTGACCGCCGCCCTGGACCGAGGGAACCTTAAGTCAGAATTCCTACAAGAATCCAATCTGATCATGGCCAAGTTGAATTATGTGG
AAGGTGATTATAAAGAAGCTCTGAACATTTACGCCCGGGTGGGCCTGGACGATCTGCCACTGACAGCTGTCCCGCCCTACAGGCTGCGGG
TGATCGCAGAAGCCTACGCTACCAAAGGACTTTGTTTGGAGAAGCTGCCTATTTCTTCTTCTACCAGTAATCTCCATGTGGACCGGGAAC
AGGATGTCATCACCTGTTATGAGAAAGCAGGGGACATCGCACTCCTGTATCTCCAAGAGATAGAAAGGGTAATACTTTCTAATATTCAAA
ACAGAAGCCCTAAGCCTGGCCCTGCTCCCCACGATCAAGAACTAGGTTTTTTCCTAGAAACAGGACTTCAGAGAGCCCATGTCCTCTATT
TCAAAAATGGGAACTTGACAAGAGGAGTCGGAAGATTTAGAGAGCTTCTCAGAGCAGTTGAAACAAGAACGACTCAAAACCTGCGAATGA
CAATAGCCAGGCAGCTGGCAGAGATCTTGTTGCGGGGTATGTGTGAGCAGAGCTACTGGAACCCTCTGGAGGATCCACCGTGCCAGTCAC
CTCTGGACGATCCTCTCCGCAAAGGAGCAAACACAAAAACCTACACTCTCACTCGGAGAGCCCGTGTCTACTCAGGAGAGAACATTTTTT
GTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGGACGCTGTGCTGAGCAGGATACCTG
AACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTGCTCTTGGAAGAAGAGGCCAGTATG
AGATGCTGTCAGAGGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAAAAATCACTACATGGCAAGGATAGTGGAACTTACGTCTCAGT
TGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGCACTGTCTAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAG
CATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCAGGATGAGCTGACAACTACCAAGAGGAGTTACGAGGATCAGT
TAAGTATGATGAGTGACCACCTGTGCAGCATGAATGAGACATTATCTAAACAGAGAGAAGAGATTGACACACTAAAGATGTCCAGTAAGG
GGAATTCTAAAAAGAACAAGAGTCGATAGTTTTGAAATAGCTGGTTGGCGACTGTTCTTTCCAGACCTGCTCCTGCTGCACAGAGCCGCA
GGGCTGAGACCACGTCCATGCTGGCTGCCTTCAGGAAGCTAAAGTATTGTTGGACCTAGTAAACTAGTCAGTGTTGGAAACGGCCTTGAA
ATATTTAAAACATATTTGTAACCAGTGAGGCAAATACAGAAGTTGATGTCGGCAGTAAATGGAAAACAATACGTATGTCATGGATATTGT
AGGTTTCCTTATGCTGTTTTTACTGTGCACTTTTTAAAATTAGGTTTTAATTTCAGTATGTAAGAACAAATATTTTGTATACTTTCAAAC
TCAATTATATGGTAATCGATTTGGTATCTATGGAATAGATATATGTTTCTGGAAAAAAATGCTTAAATTGTCAAACTGTCATTACTTCTT
ATTATAGTTGAAGGCATTCTCCAGATTCTTTTTAAAAGATTTGTTCATATTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTCTTTCTC
TCTGAGGGAGAGGGAGCCCTCCAAACTTCAGATCCTGTGGGTTTAGTATCATTATCTTCAGCTCTTTGATACCCTGTGTTAGAGTAATAG

>95110_95110_1_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000328459_PPP1R21_chr2_48734408_ENST00000281394_length(amino acids)=508AA_BP=384
MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGASPRGPKPQLTEVRKHLTAALDRGN
LKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG
DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILL
RGMCEQSYWNPLEDPPCQSPLDDPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ
SASVVYDLLTIALGRRGQYEMLSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ

--------------------------------------------------------------
>95110_95110_2_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000328459_PPP1R21_chr2_48734408_ENST00000294952_length(transcript)=2291nt_BP=1274nt
GTTACGCCGCGGAGCCGGGAGCCGGAGCCCGAGCCCGCGGCGGCGGCGGGAGGCGGCGAGGGGGCGCCGCGGCGGCGGCGGTGGGGCCTG
CGGGGCGGGCGGCCGGGCCCGGCCAGGCCGCGATGGCGACCAAGAAGGCAGGCTCGCGGCTGGAGACGGAGATCGAGCGCTGCCGCTCCG
AGTGCCAGTGGGAGCGGATCCCTGAGCTCGTCAAGCAGCTGTCGGCCAAGCTCATCGCCAACGATGACATGGCAGAGCTTCTCCTCGGGG
AGTCGAAGCTGGAGCAGTACCTGAAGGAACACCCCCTGAGGCAGGGGGCCAGTCCCCGAGGCCCCAAGCCCCAGCTGACTGAGGTCCGCA
AGCATCTGACCGCCGCCCTGGACCGAGGGAACCTTAAGTCAGAATTCCTACAAGAATCCAATCTGATCATGGCCAAGTTGAATTATGTGG
AAGGTGATTATAAAGAAGCTCTGAACATTTACGCCCGGGTGGGCCTGGACGATCTGCCACTGACAGCTGTCCCGCCCTACAGGCTGCGGG
TGATCGCAGAAGCCTACGCTACCAAAGGACTTTGTTTGGAGAAGCTGCCTATTTCTTCTTCTACCAGTAATCTCCATGTGGACCGGGAAC
AGGATGTCATCACCTGTTATGAGAAAGCAGGGGACATCGCACTCCTGTATCTCCAAGAGATAGAAAGGGTAATACTTTCTAATATTCAAA
ACAGAAGCCCTAAGCCTGGCCCTGCTCCCCACGATCAAGAACTAGGTTTTTTCCTAGAAACAGGACTTCAGAGAGCCCATGTCCTCTATT
TCAAAAATGGGAACTTGACAAGAGGAGTCGGAAGATTTAGAGAGCTTCTCAGAGCAGTTGAAACAAGAACGACTCAAAACCTGCGAATGA
CAATAGCCAGGCAGCTGGCAGAGATCTTGTTGCGGGGTATGTGTGAGCAGAGCTACTGGAACCCTCTGGAGGATCCACCGTGCCAGTCAC
CTCTGGACGATCCTCTCCGCAAAGGAGCAAACACAAAAACCTACACTCTCACTCGGAGAGCCCGTGTCTACTCAGGAGAGAACATTTTTT
GTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGGACGCTGTGCTGAGCAGGATACCTG
AACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTGCTCTTGGAAGAAGAGGCCAGTATG
AGATGCTGTCAGAGGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAAAAATCACTACATGGCAAGGATAGTGGAACTTACGTCTCAGT
TGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGCACTGTCTAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAG
CATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCAGGATGAGCTGACAACTACCAAGAGGAGTTACGAGGATCAGT
TAAGTATGATGAGTGACCACCTGTGCAGCATGAATGAGACATTATCTAAACAGAGAGAAGAGATTGACACACTAAAGATGTCCAGTAAGG
GGAATTCTAAAAAGAACAAGAGTCGATAGTTTTGAAATAGCTGGTTGGCGACTGTTCTTTCCAGACCTGCTCCTGCTGCACAGAGCCGCA
GGGCTGAGACCACGTCCATGCTGGCTGCCTTCAGGAAGCTAAAGTATTGTTGGACCTAGTAAACTAGTCAGTGTTGGAAACGGCCTTGAA
ATATTTAAAACATATTTGTAACCAGTGAGGCAAATACAGAAGTTGATGTCGGCAGTAAATGGAAAACAATACGTATGTCATGGATATTGT
AGGTTTCCTTATGCTGTTTTTACTGTGCACTTTTTAAAATTAGGTTTTAATTTCAGTATGTAAGAACAAATATTTTGTATACTTTCAAAC
TCAATTATATGGTAATCGATTTGGTATCTATGGAATAGATATATGTTTCTGGAAAAAAATGCTTAAATTGTCAAACTGTCATTACTTCTT
ATTATAGTTGAAGGCATTCTCCAGATTCTTTTTAAAAGATTTGTTCATATTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTCTTTCTC
TCTGAGGGAGAGGGAGCCCTCCAAACTTCAGATCCTGTGGGTTTAGTATCATTATCTTCAGCTCTTTGATACCCTGTGTTAGAGTAATAG

>95110_95110_2_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000328459_PPP1R21_chr2_48734408_ENST00000294952_length(amino acids)=508AA_BP=384
MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGASPRGPKPQLTEVRKHLTAALDRGN
LKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG
DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILL
RGMCEQSYWNPLEDPPCQSPLDDPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ
SASVVYDLLTIALGRRGQYEMLSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ

--------------------------------------------------------------
>95110_95110_3_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000328459_PPP1R21_chr2_48734408_ENST00000449090_length(transcript)=1713nt_BP=1274nt
GTTACGCCGCGGAGCCGGGAGCCGGAGCCCGAGCCCGCGGCGGCGGCGGGAGGCGGCGAGGGGGCGCCGCGGCGGCGGCGGTGGGGCCTG
CGGGGCGGGCGGCCGGGCCCGGCCAGGCCGCGATGGCGACCAAGAAGGCAGGCTCGCGGCTGGAGACGGAGATCGAGCGCTGCCGCTCCG
AGTGCCAGTGGGAGCGGATCCCTGAGCTCGTCAAGCAGCTGTCGGCCAAGCTCATCGCCAACGATGACATGGCAGAGCTTCTCCTCGGGG
AGTCGAAGCTGGAGCAGTACCTGAAGGAACACCCCCTGAGGCAGGGGGCCAGTCCCCGAGGCCCCAAGCCCCAGCTGACTGAGGTCCGCA
AGCATCTGACCGCCGCCCTGGACCGAGGGAACCTTAAGTCAGAATTCCTACAAGAATCCAATCTGATCATGGCCAAGTTGAATTATGTGG
AAGGTGATTATAAAGAAGCTCTGAACATTTACGCCCGGGTGGGCCTGGACGATCTGCCACTGACAGCTGTCCCGCCCTACAGGCTGCGGG
TGATCGCAGAAGCCTACGCTACCAAAGGACTTTGTTTGGAGAAGCTGCCTATTTCTTCTTCTACCAGTAATCTCCATGTGGACCGGGAAC
AGGATGTCATCACCTGTTATGAGAAAGCAGGGGACATCGCACTCCTGTATCTCCAAGAGATAGAAAGGGTAATACTTTCTAATATTCAAA
ACAGAAGCCCTAAGCCTGGCCCTGCTCCCCACGATCAAGAACTAGGTTTTTTCCTAGAAACAGGACTTCAGAGAGCCCATGTCCTCTATT
TCAAAAATGGGAACTTGACAAGAGGAGTCGGAAGATTTAGAGAGCTTCTCAGAGCAGTTGAAACAAGAACGACTCAAAACCTGCGAATGA
CAATAGCCAGGCAGCTGGCAGAGATCTTGTTGCGGGGTATGTGTGAGCAGAGCTACTGGAACCCTCTGGAGGATCCACCGTGCCAGTCAC
CTCTGGACGATCCTCTCCGCAAAGGAGCAAACACAAAAACCTACACTCTCACTCGGAGAGCCCGTGTCTACTCAGGAGAGAACATTTTTT
GTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGGACGCTGTGCTGAGCAGGATACCTG
AACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTGCTCTTGGAAGAAGAGGCCAGTATG
AGATGCTGTCAGAGGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAAAAATCACTACATGGCAAGGATAGTGGAACTTACGTCTCAGT
TGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGCACTGTCTAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAG
CATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCAGGATGAGCTGACAACTACCAAGAGGAGTTACGAGGATCAGT
TAAGTATGATGAGTGACCACCTGTGCAGCATGAATGAGACATTATCTAAACAGAGAGAAGAGATTGACACACTAAAGATGTCCAGTAAGG
GGAATTCTAAAAAGAACAAGAGTCGATAGTTTTGAAATAGCTGGTTGGCGACTGTTCTTTCCAGACCTGCTCCTGCTGCACAGAGCCGCA

>95110_95110_3_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000328459_PPP1R21_chr2_48734408_ENST00000449090_length(amino acids)=508AA_BP=384
MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGASPRGPKPQLTEVRKHLTAALDRGN
LKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG
DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILL
RGMCEQSYWNPLEDPPCQSPLDDPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ
SASVVYDLLTIALGRRGQYEMLSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ

--------------------------------------------------------------
>95110_95110_4_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000357056_PPP1R21_chr2_48734408_ENST00000281394_length(transcript)=2291nt_BP=1274nt
GTTACGCCGCGGAGCCGGGAGCCGGAGCCCGAGCCCGCGGCGGCGGCGGGAGGCGGCGAGGGGGCGCCGCGGCGGCGGCGGTGGGGCCTG
CGGGGCGGGCGGCCGGGCCCGGCCAGGCCGCGATGGCGACCAAGAAGGCAGGCTCGCGGCTGGAGACGGAGATCGAGCGCTGCCGCTCCG
AGTGCCAGTGGGAGCGGATCCCTGAGCTCGTCAAGCAGCTGTCGGCCAAGCTCATCGCCAACGATGACATGGCAGAGCTTCTCCTCGGGG
AGTCGAAGCTGGAGCAGTACCTGAAGGAACACCCCCTGAGGCAGGGGGCCAGTCCCCGAGGCCCCAAGCCCCAGCTGACTGAGGTCCGCA
AGCATCTGACCGCCGCCCTGGACCGAGGGAACCTTAAGTCAGAATTCCTACAAGAATCCAATCTGATCATGGCCAAGTTGAATTATGTGG
AAGGTGATTATAAAGAAGCTCTGAACATTTACGCCCGGGTGGGCCTGGACGATCTGCCACTGACAGCTGTCCCGCCCTACAGGCTGCGGG
TGATCGCAGAAGCCTACGCTACCAAAGGACTTTGTTTGGAGAAGCTGCCTATTTCTTCTTCTACCAGTAATCTCCATGTGGACCGGGAAC
AGGATGTCATCACCTGTTATGAGAAAGCAGGGGACATCGCACTCCTGTATCTCCAAGAGATAGAAAGGGTAATACTTTCTAATATTCAAA
ACAGAAGCCCTAAGCCTGGCCCTGCTCCCCACGATCAAGAACTAGGTTTTTTCCTAGAAACAGGACTTCAGAGAGCCCATGTCCTCTATT
TCAAAAATGGGAACTTGACAAGAGGAGTCGGAAGATTTAGAGAGCTTCTCAGAGCAGTTGAAACAAGAACGACTCAAAACCTGCGAATGA
CAATAGCCAGGCAGCTGGCAGAGATCTTGTTGCGGGGTATGTGTGAGCAGAGCTACTGGAACCCTCTGGAGGATCCACCGTGCCAGTCAC
CTCTGGACGATCCTCTCCGCAAAGGAGCAAACACAAAAACCTACACTCTCACTCGGAGAGCCCGTGTCTACTCAGGAGAGAACATTTTTT
GTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGGACGCTGTGCTGAGCAGGATACCTG
AACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTGCTCTTGGAAGAAGAGGCCAGTATG
AGATGCTGTCAGAGGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAAAAATCACTACATGGCAAGGATAGTGGAACTTACGTCTCAGT
TGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGCACTGTCTAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAG
CATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCAGGATGAGCTGACAACTACCAAGAGGAGTTACGAGGATCAGT
TAAGTATGATGAGTGACCACCTGTGCAGCATGAATGAGACATTATCTAAACAGAGAGAAGAGATTGACACACTAAAGATGTCCAGTAAGG
GGAATTCTAAAAAGAACAAGAGTCGATAGTTTTGAAATAGCTGGTTGGCGACTGTTCTTTCCAGACCTGCTCCTGCTGCACAGAGCCGCA
GGGCTGAGACCACGTCCATGCTGGCTGCCTTCAGGAAGCTAAAGTATTGTTGGACCTAGTAAACTAGTCAGTGTTGGAAACGGCCTTGAA
ATATTTAAAACATATTTGTAACCAGTGAGGCAAATACAGAAGTTGATGTCGGCAGTAAATGGAAAACAATACGTATGTCATGGATATTGT
AGGTTTCCTTATGCTGTTTTTACTGTGCACTTTTTAAAATTAGGTTTTAATTTCAGTATGTAAGAACAAATATTTTGTATACTTTCAAAC
TCAATTATATGGTAATCGATTTGGTATCTATGGAATAGATATATGTTTCTGGAAAAAAATGCTTAAATTGTCAAACTGTCATTACTTCTT
ATTATAGTTGAAGGCATTCTCCAGATTCTTTTTAAAAGATTTGTTCATATTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTCTTTCTC
TCTGAGGGAGAGGGAGCCCTCCAAACTTCAGATCCTGTGGGTTTAGTATCATTATCTTCAGCTCTTTGATACCCTGTGTTAGAGTAATAG

>95110_95110_4_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000357056_PPP1R21_chr2_48734408_ENST00000281394_length(amino acids)=508AA_BP=384
MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGASPRGPKPQLTEVRKHLTAALDRGN
LKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG
DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILL
RGMCEQSYWNPLEDPPCQSPLDDPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ
SASVVYDLLTIALGRRGQYEMLSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ

--------------------------------------------------------------
>95110_95110_5_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000357056_PPP1R21_chr2_48734408_ENST00000294952_length(transcript)=2291nt_BP=1274nt
GTTACGCCGCGGAGCCGGGAGCCGGAGCCCGAGCCCGCGGCGGCGGCGGGAGGCGGCGAGGGGGCGCCGCGGCGGCGGCGGTGGGGCCTG
CGGGGCGGGCGGCCGGGCCCGGCCAGGCCGCGATGGCGACCAAGAAGGCAGGCTCGCGGCTGGAGACGGAGATCGAGCGCTGCCGCTCCG
AGTGCCAGTGGGAGCGGATCCCTGAGCTCGTCAAGCAGCTGTCGGCCAAGCTCATCGCCAACGATGACATGGCAGAGCTTCTCCTCGGGG
AGTCGAAGCTGGAGCAGTACCTGAAGGAACACCCCCTGAGGCAGGGGGCCAGTCCCCGAGGCCCCAAGCCCCAGCTGACTGAGGTCCGCA
AGCATCTGACCGCCGCCCTGGACCGAGGGAACCTTAAGTCAGAATTCCTACAAGAATCCAATCTGATCATGGCCAAGTTGAATTATGTGG
AAGGTGATTATAAAGAAGCTCTGAACATTTACGCCCGGGTGGGCCTGGACGATCTGCCACTGACAGCTGTCCCGCCCTACAGGCTGCGGG
TGATCGCAGAAGCCTACGCTACCAAAGGACTTTGTTTGGAGAAGCTGCCTATTTCTTCTTCTACCAGTAATCTCCATGTGGACCGGGAAC
AGGATGTCATCACCTGTTATGAGAAAGCAGGGGACATCGCACTCCTGTATCTCCAAGAGATAGAAAGGGTAATACTTTCTAATATTCAAA
ACAGAAGCCCTAAGCCTGGCCCTGCTCCCCACGATCAAGAACTAGGTTTTTTCCTAGAAACAGGACTTCAGAGAGCCCATGTCCTCTATT
TCAAAAATGGGAACTTGACAAGAGGAGTCGGAAGATTTAGAGAGCTTCTCAGAGCAGTTGAAACAAGAACGACTCAAAACCTGCGAATGA
CAATAGCCAGGCAGCTGGCAGAGATCTTGTTGCGGGGTATGTGTGAGCAGAGCTACTGGAACCCTCTGGAGGATCCACCGTGCCAGTCAC
CTCTGGACGATCCTCTCCGCAAAGGAGCAAACACAAAAACCTACACTCTCACTCGGAGAGCCCGTGTCTACTCAGGAGAGAACATTTTTT
GTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGGACGCTGTGCTGAGCAGGATACCTG
AACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTGCTCTTGGAAGAAGAGGCCAGTATG
AGATGCTGTCAGAGGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAAAAATCACTACATGGCAAGGATAGTGGAACTTACGTCTCAGT
TGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGCACTGTCTAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAG
CATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCAGGATGAGCTGACAACTACCAAGAGGAGTTACGAGGATCAGT
TAAGTATGATGAGTGACCACCTGTGCAGCATGAATGAGACATTATCTAAACAGAGAGAAGAGATTGACACACTAAAGATGTCCAGTAAGG
GGAATTCTAAAAAGAACAAGAGTCGATAGTTTTGAAATAGCTGGTTGGCGACTGTTCTTTCCAGACCTGCTCCTGCTGCACAGAGCCGCA
GGGCTGAGACCACGTCCATGCTGGCTGCCTTCAGGAAGCTAAAGTATTGTTGGACCTAGTAAACTAGTCAGTGTTGGAAACGGCCTTGAA
ATATTTAAAACATATTTGTAACCAGTGAGGCAAATACAGAAGTTGATGTCGGCAGTAAATGGAAAACAATACGTATGTCATGGATATTGT
AGGTTTCCTTATGCTGTTTTTACTGTGCACTTTTTAAAATTAGGTTTTAATTTCAGTATGTAAGAACAAATATTTTGTATACTTTCAAAC
TCAATTATATGGTAATCGATTTGGTATCTATGGAATAGATATATGTTTCTGGAAAAAAATGCTTAAATTGTCAAACTGTCATTACTTCTT
ATTATAGTTGAAGGCATTCTCCAGATTCTTTTTAAAAGATTTGTTCATATTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTCTTTCTC
TCTGAGGGAGAGGGAGCCCTCCAAACTTCAGATCCTGTGGGTTTAGTATCATTATCTTCAGCTCTTTGATACCCTGTGTTAGAGTAATAG

>95110_95110_5_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000357056_PPP1R21_chr2_48734408_ENST00000294952_length(amino acids)=508AA_BP=384
MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGASPRGPKPQLTEVRKHLTAALDRGN
LKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG
DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILL
RGMCEQSYWNPLEDPPCQSPLDDPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ
SASVVYDLLTIALGRRGQYEMLSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ

--------------------------------------------------------------
>95110_95110_6_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000357056_PPP1R21_chr2_48734408_ENST00000449090_length(transcript)=1713nt_BP=1274nt
GTTACGCCGCGGAGCCGGGAGCCGGAGCCCGAGCCCGCGGCGGCGGCGGGAGGCGGCGAGGGGGCGCCGCGGCGGCGGCGGTGGGGCCTG
CGGGGCGGGCGGCCGGGCCCGGCCAGGCCGCGATGGCGACCAAGAAGGCAGGCTCGCGGCTGGAGACGGAGATCGAGCGCTGCCGCTCCG
AGTGCCAGTGGGAGCGGATCCCTGAGCTCGTCAAGCAGCTGTCGGCCAAGCTCATCGCCAACGATGACATGGCAGAGCTTCTCCTCGGGG
AGTCGAAGCTGGAGCAGTACCTGAAGGAACACCCCCTGAGGCAGGGGGCCAGTCCCCGAGGCCCCAAGCCCCAGCTGACTGAGGTCCGCA
AGCATCTGACCGCCGCCCTGGACCGAGGGAACCTTAAGTCAGAATTCCTACAAGAATCCAATCTGATCATGGCCAAGTTGAATTATGTGG
AAGGTGATTATAAAGAAGCTCTGAACATTTACGCCCGGGTGGGCCTGGACGATCTGCCACTGACAGCTGTCCCGCCCTACAGGCTGCGGG
TGATCGCAGAAGCCTACGCTACCAAAGGACTTTGTTTGGAGAAGCTGCCTATTTCTTCTTCTACCAGTAATCTCCATGTGGACCGGGAAC
AGGATGTCATCACCTGTTATGAGAAAGCAGGGGACATCGCACTCCTGTATCTCCAAGAGATAGAAAGGGTAATACTTTCTAATATTCAAA
ACAGAAGCCCTAAGCCTGGCCCTGCTCCCCACGATCAAGAACTAGGTTTTTTCCTAGAAACAGGACTTCAGAGAGCCCATGTCCTCTATT
TCAAAAATGGGAACTTGACAAGAGGAGTCGGAAGATTTAGAGAGCTTCTCAGAGCAGTTGAAACAAGAACGACTCAAAACCTGCGAATGA
CAATAGCCAGGCAGCTGGCAGAGATCTTGTTGCGGGGTATGTGTGAGCAGAGCTACTGGAACCCTCTGGAGGATCCACCGTGCCAGTCAC
CTCTGGACGATCCTCTCCGCAAAGGAGCAAACACAAAAACCTACACTCTCACTCGGAGAGCCCGTGTCTACTCAGGAGAGAACATTTTTT
GTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGGACGCTGTGCTGAGCAGGATACCTG
AACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTGCTCTTGGAAGAAGAGGCCAGTATG
AGATGCTGTCAGAGGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAAAAATCACTACATGGCAAGGATAGTGGAACTTACGTCTCAGT
TGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGCACTGTCTAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAG
CATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCAGGATGAGCTGACAACTACCAAGAGGAGTTACGAGGATCAGT
TAAGTATGATGAGTGACCACCTGTGCAGCATGAATGAGACATTATCTAAACAGAGAGAAGAGATTGACACACTAAAGATGTCCAGTAAGG
GGAATTCTAAAAAGAACAAGAGTCGATAGTTTTGAAATAGCTGGTTGGCGACTGTTCTTTCCAGACCTGCTCCTGCTGCACAGAGCCGCA

>95110_95110_6_TTC7B-PPP1R21_TTC7B_chr14_91142867_ENST00000357056_PPP1R21_chr2_48734408_ENST00000449090_length(amino acids)=508AA_BP=384
MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGASPRGPKPQLTEVRKHLTAALDRGN
LKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG
DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILL
RGMCEQSYWNPLEDPPCQSPLDDPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ
SASVVYDLLTIALGRRGQYEMLSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TTC7B-PPP1R21


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTC7B-PPP1R21


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTC7B-PPP1R21


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource