FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TTLL11-INVS (FusionGDB2 ID:95146)

Fusion Gene Summary for TTLL11-INVS

check button Fusion gene summary
Fusion gene informationFusion gene name: TTLL11-INVS
Fusion gene ID: 95146
HgeneTgene
Gene symbol

TTLL11

INVS

Gene ID

158135

27130

Gene nametubulin tyrosine ligase like 11inversin
SynonymsC9orf20|bA244O19.1INV|NPH2|NPHP2
Cytomap

9q33.2

9q31.1

Type of geneprotein-codingprotein-coding
Descriptiontubulin polyglutamylase TTLL11tubulin tyrosine ligase like11tubulin tyrosine ligase-like family, member 11tubulin--tyrosine ligase-like protein 11inversininversion of embryo turning homologinversion of embryonic turningnephrocystin-2
Modification date2020031320200313
UniProtAcc.

Q9Y283

Ensembl transtripts involved in fusion geneENST00000321582, ENST00000373776, 
ENST00000474723, 		ENST00000374921, 
ENST00000460636, ENST00000262456, 
ENST00000262457, ENST00000541287, 
Fusion gene scores* DoF score8 X 8 X 6=3842 X 2 X 2=8
# samples 92
** MAII scorelog2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: TTLL11 [Title/Abstract] AND INVS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTLL11(124801550)-INVS(103054607), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINVS

GO:0090090

negative regulation of canonical Wnt signaling pathway

18371931


check buttonFusion gene breakpoints across TTLL11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across INVS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer235NTTLL11chr9

124801550

-INVSchr9

103054607

+


Top

Fusion Gene ORF analysis for TTLL11-INVS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000321582ENST00000374921TTLL11chr9

124801550

-INVSchr9

103054607

+
5CDS-intronENST00000321582ENST00000460636TTLL11chr9

124801550

-INVSchr9

103054607

+
5CDS-intronENST00000373776ENST00000374921TTLL11chr9

124801550

-INVSchr9

103054607

+
5CDS-intronENST00000373776ENST00000460636TTLL11chr9

124801550

-INVSchr9

103054607

+
5UTR-3CDSENST00000474723ENST00000262456TTLL11chr9

124801550

-INVSchr9

103054607

+
5UTR-3CDSENST00000474723ENST00000262457TTLL11chr9

124801550

-INVSchr9

103054607

+
5UTR-3CDSENST00000474723ENST00000541287TTLL11chr9

124801550

-INVSchr9

103054607

+
5UTR-intronENST00000474723ENST00000374921TTLL11chr9

124801550

-INVSchr9

103054607

+
5UTR-intronENST00000474723ENST00000460636TTLL11chr9

124801550

-INVSchr9

103054607

+
In-frameENST00000321582ENST00000262456TTLL11chr9

124801550

-INVSchr9

103054607

+
In-frameENST00000321582ENST00000262457TTLL11chr9

124801550

-INVSchr9

103054607

+
In-frameENST00000321582ENST00000541287TTLL11chr9

124801550

-INVSchr9

103054607

+
In-frameENST00000373776ENST00000262456TTLL11chr9

124801550

-INVSchr9

103054607

+
In-frameENST00000373776ENST00000262457TTLL11chr9

124801550

-INVSchr9

103054607

+
In-frameENST00000373776ENST00000541287TTLL11chr9

124801550

-INVSchr9

103054607

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321582TTLL11chr9124801550-ENST00000262457INVSchr9103054607+24731017382146702
ENST00000321582TTLL11chr9124801550-ENST00000541287INVSchr9103054607+23381017382203721
ENST00000321582TTLL11chr9124801550-ENST00000262456INVSchr9103054607+17511017381636532
ENST00000373776TTLL11chr9124801550-ENST00000262457INVSchr9103054607+24731017382146702
ENST00000373776TTLL11chr9124801550-ENST00000541287INVSchr9103054607+23381017382203721
ENST00000373776TTLL11chr9124801550-ENST00000262456INVSchr9103054607+17511017381636532

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321582ENST00000262457TTLL11chr9124801550-INVSchr9103054607+0.0807031240.91929686
ENST00000321582ENST00000541287TTLL11chr9124801550-INVSchr9103054607+0.0612575340.93874246
ENST00000321582ENST00000262456TTLL11chr9124801550-INVSchr9103054607+0.076653890.92334616
ENST00000373776ENST00000262457TTLL11chr9124801550-INVSchr9103054607+0.0807031240.91929686
ENST00000373776ENST00000541287TTLL11chr9124801550-INVSchr9103054607+0.0612575340.93874246
ENST00000373776ENST00000262456TTLL11chr9124801550-INVSchr9103054607+0.076653890.92334616

Top

Fusion Genomic Features for TTLL11-INVS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TTLL11chr9124801550-INVSchr9103054607+3.47E-081
TTLL11chr9124801550-INVSchr9103054607+3.47E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for TTLL11-INVS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:124801550/chr9:103054607)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.INVS

Q9Y283

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15852005, ECO:0000269|PubMed:18371931}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218916_945689896.0DomainIQ 2
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217916_9456891066.0DomainIQ 2
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104555_5840102.0DomainIQ 1
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104916_9450102.0DomainIQ 2
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218909_917689896.0MotifNote=D-box 2
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217909_9176891066.0MotifNote=D-box 2
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104490_4980102.0MotifNote=D-box 1
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104909_9170102.0MotifNote=D-box 2
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104113_1440102.0RepeatNote=ANK 4
TgeneINVSchr9:124801550chr9:103054607ENST000003749210413_420102.0RepeatNote=ANK 1
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104148_1770102.0RepeatNote=ANK 5
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104181_2130102.0RepeatNote=ANK 6
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104220_2500102.0RepeatNote=ANK 7
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104254_2830102.0RepeatNote=ANK 8
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104288_3170102.0RepeatNote=ANK 9
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104321_3500102.0RepeatNote=ANK 10
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104356_3850102.0RepeatNote=ANK 11
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104389_4180102.0RepeatNote=ANK 12
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104422_4510102.0RepeatNote=ANK 13
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104455_4840102.0RepeatNote=ANK 14
TgeneINVSchr9:124801550chr9:103054607ENST000003749210447_760102.0RepeatNote=ANK 2
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104488_5170102.0RepeatNote=ANK 15
TgeneINVSchr9:124801550chr9:103054607ENST0000037492104523_5530102.0RepeatNote=ANK 16
TgeneINVSchr9:124801550chr9:103054607ENST000003749210480_1100102.0RepeatNote=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTLL11chr9:124801550chr9:103054607ENST00000373776-24218_570276539.0DomainTTL
HgeneTTLL11chr9:124801550chr9:103054607ENST00000373776-24372_375276539.0Nucleotide bindingATP binding
HgeneTTLL11chr9:124801550chr9:103054607ENST00000373776-24557_628276539.0Regionc-MTBD region
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218555_584689896.0DomainIQ 1
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217555_5846891066.0DomainIQ 1
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218490_498689896.0MotifNote=D-box 1
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217490_4986891066.0MotifNote=D-box 1
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218113_144689896.0RepeatNote=ANK 4
TgeneINVSchr9:124801550chr9:103054607ENST00000262456121813_42689896.0RepeatNote=ANK 1
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218148_177689896.0RepeatNote=ANK 5
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218181_213689896.0RepeatNote=ANK 6
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218220_250689896.0RepeatNote=ANK 7
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218254_283689896.0RepeatNote=ANK 8
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218288_317689896.0RepeatNote=ANK 9
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218321_350689896.0RepeatNote=ANK 10
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218356_385689896.0RepeatNote=ANK 11
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218389_418689896.0RepeatNote=ANK 12
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218422_451689896.0RepeatNote=ANK 13
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218455_484689896.0RepeatNote=ANK 14
TgeneINVSchr9:124801550chr9:103054607ENST00000262456121847_76689896.0RepeatNote=ANK 2
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218488_517689896.0RepeatNote=ANK 15
TgeneINVSchr9:124801550chr9:103054607ENST000002624561218523_553689896.0RepeatNote=ANK 16
TgeneINVSchr9:124801550chr9:103054607ENST00000262456121880_110689896.0RepeatNote=ANK 3
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217113_1446891066.0RepeatNote=ANK 4
TgeneINVSchr9:124801550chr9:103054607ENST00000262457121713_426891066.0RepeatNote=ANK 1
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217148_1776891066.0RepeatNote=ANK 5
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217181_2136891066.0RepeatNote=ANK 6
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217220_2506891066.0RepeatNote=ANK 7
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217254_2836891066.0RepeatNote=ANK 8
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217288_3176891066.0RepeatNote=ANK 9
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217321_3506891066.0RepeatNote=ANK 10
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217356_3856891066.0RepeatNote=ANK 11
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217389_4186891066.0RepeatNote=ANK 12
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217422_4516891066.0RepeatNote=ANK 13
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217455_4846891066.0RepeatNote=ANK 14
TgeneINVSchr9:124801550chr9:103054607ENST00000262457121747_766891066.0RepeatNote=ANK 2
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217488_5176891066.0RepeatNote=ANK 15
TgeneINVSchr9:124801550chr9:103054607ENST000002624571217523_5536891066.0RepeatNote=ANK 16
TgeneINVSchr9:124801550chr9:103054607ENST00000262457121780_1106891066.0RepeatNote=ANK 3


Top

Fusion Gene Sequence for TTLL11-INVS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95146_95146_1_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000321582_INVS_chr9_103054607_ENST00000262456_length(transcript)=1751nt_BP=1017nt
CGAGTGTTGGCGGGGACTGAGCCTCCTGCTTGAGGTAGTTGTTTTTACTCCCAGTCCCCAGGCTCACGAGCCCCACGCGCGCTCAATCTG
CCCTCCCGCTTCTCCTCGCCACTCCGAGTTCTGCGCCCTCGAGATCCAGCGCATCCGCGGGGTGGGCGGGTCCTGGCGGCTCTTTGCCCT
CTTCCAACATGGCCGCCGCTGCCTCTGTGACAGGCAGGGTCACGTGGGCAGCCTCGCCTATGAGGTCGCTGGGGCTCGGCCGGCGATTGT
CCCTTCCCGGACCCCGTCTCGATGCGGTGACTGCCGCTGTCAACCCGAGCCTGAGCGATCATGGCAACGGGCTCGGGCGGGGAACGCGTG
GCAGCGGCTGCAGCGGCGGCAGTTTGGTGGCGGACTGGGGCGGCGGAGCGGCGGCGGCGGCGGCGGTGGCACTGGCACTGGCCCCGGCCC
TGAGCACCATGCGGCGGGGCAGCTCCGAGAGCGAGCTGGCGGCCCGGTGGGAGGCGGAGGCGGTGGCTGCGGCCAAAGCGGCGGCCAAAG
CTGAGGCCGAGGCCACAGCGGAGACGGTGGCGGAACAGGTCCGCGTGGACGCGGGCGCGGCCGGGGAACCGGAGTGCAAGGCAGGGGAGG
AGCAGCCCAAGGTCCTGGCCCCGGCCCCGGCGCAGCCCAGTGCGGCTGAGGAGGGGAACACCCAGGTCCTTCAGCGGCCGCCGCCCACGC
TGCCCCCGTCCAAGCCGAAGCCGGTGCAGGGCCTCTGCCCGCACGGGAAGCCCCGGGACAAGGGCCGAAGCTGCAAGCGGAGCTCGGGCC
ACGGTTCCGGCGAGAACGGCTCCCAGCGGCCGGTCACCGTGGACAGCTCCAAGGCCAGGACCTCCCTGGATGCCCTGAAGATCAGCATCC
GCCAGCTCAAGTGGAAGGAGTTCCCATTTGGCCGGCGCTTGCCTTGTGACATCTACTGGCATGGAGTTTCATTTCACGACAATGACATAT
TCTCCGGTCAAGTGAACAAGTTTCCAGAAACAGCCAGAGAACATTCTAAAGGCCAATCTGCTTGTGTCCACTTCAGACCCAATGAAGGCA
GTGATGGAAGCAGGCATCCAGGAGTTCCCTCTGTTGAGAAGTCCAGAGAGCTCCGACTGCAGATAATTCAGAGAGAACGAAGGAGGAAGG
AGCTGTTTCGCAAAAAGAACAAGGCAGCAGCAGTCATCCAGCGCGCCTGGCGAAGCTACCAGCTCAGGAAGCACCTGTCCCACCTTCGGC
ATATGAAGCAGCTTGGAGCTGGAGATGTGGACAGATGGAGGCAAGAGTCTACAGCATTGCTCCTCCAGGTTTGGAGGAAGGAACTGGAAC
TAAAATTCCCCCAAACCACTGCAGTAAGCAAGGCCCCCAAGAGTCCATCCAAGGGCACCTCAGGCACAAAGTCCACCAAGCACTCAGTGC
TTAAGCAAATCTATGGTTGTTCTCACGAAGGGAAAATACATCATCCTACAAGATCTGTAAAAGCCTCTTCTGTGCTGCGTCTCAACTCAG
TGAGCAACCTACAGTGTATACATCTCCTTGAGAACAGTGGAAGATCAAAGAACTTTTCTTATAACCTGCAATCAGCTACTCAGCCAAAAA
ACAAAACAAAACCTTGACTGCCTATGGAGGAAGACTGTGTTCGGGGGAGCTGGCATAGCTAGTGCAGAGTTCAGATTTTCTGCTGATAAT

>95146_95146_1_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000321582_INVS_chr9_103054607_ENST00000262456_length(amino acids)=532AA_BP=326
MFLLPVPRLTSPTRAQSALPLLLATPSSAPSRSSASAGWAGPGGSLPSSNMAAAASVTGRVTWAASPMRSLGLGRRLSLPGPRLDAVTAA
VNPSLSDHGNGLGRGTRGSGCSGGSLVADWGGGAAAAAAVALALAPALSTMRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQ
VRVDAGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVT
VDSSKARTSLDALKISIRQLKWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVE
KSRELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQESTALLLQVWRKELELKFPQTTAVSKAP

--------------------------------------------------------------
>95146_95146_2_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000321582_INVS_chr9_103054607_ENST00000262457_length(transcript)=2473nt_BP=1017nt
CGAGTGTTGGCGGGGACTGAGCCTCCTGCTTGAGGTAGTTGTTTTTACTCCCAGTCCCCAGGCTCACGAGCCCCACGCGCGCTCAATCTG
CCCTCCCGCTTCTCCTCGCCACTCCGAGTTCTGCGCCCTCGAGATCCAGCGCATCCGCGGGGTGGGCGGGTCCTGGCGGCTCTTTGCCCT
CTTCCAACATGGCCGCCGCTGCCTCTGTGACAGGCAGGGTCACGTGGGCAGCCTCGCCTATGAGGTCGCTGGGGCTCGGCCGGCGATTGT
CCCTTCCCGGACCCCGTCTCGATGCGGTGACTGCCGCTGTCAACCCGAGCCTGAGCGATCATGGCAACGGGCTCGGGCGGGGAACGCGTG
GCAGCGGCTGCAGCGGCGGCAGTTTGGTGGCGGACTGGGGCGGCGGAGCGGCGGCGGCGGCGGCGGTGGCACTGGCACTGGCCCCGGCCC
TGAGCACCATGCGGCGGGGCAGCTCCGAGAGCGAGCTGGCGGCCCGGTGGGAGGCGGAGGCGGTGGCTGCGGCCAAAGCGGCGGCCAAAG
CTGAGGCCGAGGCCACAGCGGAGACGGTGGCGGAACAGGTCCGCGTGGACGCGGGCGCGGCCGGGGAACCGGAGTGCAAGGCAGGGGAGG
AGCAGCCCAAGGTCCTGGCCCCGGCCCCGGCGCAGCCCAGTGCGGCTGAGGAGGGGAACACCCAGGTCCTTCAGCGGCCGCCGCCCACGC
TGCCCCCGTCCAAGCCGAAGCCGGTGCAGGGCCTCTGCCCGCACGGGAAGCCCCGGGACAAGGGCCGAAGCTGCAAGCGGAGCTCGGGCC
ACGGTTCCGGCGAGAACGGCTCCCAGCGGCCGGTCACCGTGGACAGCTCCAAGGCCAGGACCTCCCTGGATGCCCTGAAGATCAGCATCC
GCCAGCTCAAGTGGAAGGAGTTCCCATTTGGCCGGCGCTTGCCTTGTGACATCTACTGGCATGGAGTTTCATTTCACGACAATGACATAT
TCTCCGGTCAAGTGAACAAGTTTCCAGAAACAGCCAGAGAACATTCTAAAGGCCAATCTGCTTGTGTCCACTTCAGACCCAATGAAGGCA
GTGATGGAAGCAGGCATCCAGGAGTTCCCTCTGTTGAGAAGTCCAGAGGTGAGACAGCTGGCGATGAGCGGTGTGCAAAGGGGAAAGGCT
TCGTGAAGCAGCCCTCCTGTATCAGGGTGGCTGGGCCTGATGAGAAAGGAGAGGACTCCAGGCGGGCAGCTGCAAGCCTTCCACCGCACG
ATAGCCACTGGAAGCCCAGCAGGCGGCATGACACAGAACCCAAGGCCAAATGTGCCCCCCAGAAAAGGCGCACTCAAGAGCTCAGAGGAG
GAAGGTGCTCTCCGGCTGGTTCTAGCCGCCCTGGCAGTGCCCGGGGGGAGGCGGTCCATGCTGGGCAGAATCCTCCCCACCATCGTACAC
CAAGAAACAAAGTGACACAAGCCAAGCTCACAGGAGGGCTCTATTCACATTTGCCACAGAGCACAGAGGAGTTGAGGTCAGGAGCTAGGA
GGCTGGAGACATCTACCCTGTCCGAGGACTTTCAGGTATCTAAGGAGACTGATCCAGCACCTGGTCCCCTCTCTGGGCAGAGTGTGAATA
TTGACCTTCTCCCCGTAGAGCTCCGACTGCAGATAATTCAGAGAGAACGAAGGAGGAAGGAGCTGTTTCGCAAAAAGAACAAGGCAGCAG
CAGTCATCCAGCGCGCCTGGCGAAGCTACCAGCTCAGGAAGCACCTGTCCCACCTTCGGCATATGAAGCAGCTTGGAGCTGGAGATGTGG
ACAGATGGAGGCAAGAGTCTACAGCATTGCTCCTCCAGGTTTGGAGGAAGGAACTGGAACTAAAATTCCCCCAAACCACTGCAGTAAGCA
AGGCCCCCAAGAGTCCATCCAAGGGCACCTCAGGCACAAAGTCCACCAAGCACTCAGTGCTTAAGCAAATCTATGGTTGTTCTCACGAAG
GGAAAATACATCATCCTACAAGATCTGTAAAAGCCTCTTCTGTGCTGCGTCTCAACTCAGTGAGCAACCTACAGTGTATACATCTCCTTG
AGAACAGTGGAAGATCAAAGAACTTTTCTTATAACCTGCAATCAGCTACTCAGCCAAAAAACAAAACAAAACCTTGACTGCCTATGGAGG
AAGACTGTGTTCGGGGGAGCTGGCATAGCTAGTGCAGAGTTCAGATTTTCTGCTGATAATCTTTTACACCTTGGGAAAACTTTAATATCC
GTACCTGAAGGCTGATTCACCTAAAAATGTGTTAACTGAAAGAAAATGTCAGAATGTTTCCTTTCTGCTCTTACACAGCATTGTTTTGTC
AATCAACACAGCCTGCACTGAAAGGACCTGCATAGACTATGTCTGTGCAAAGTGCCTGAGTGTCTGCTTTCACCTCAGTCTGTACAGTTG

>95146_95146_2_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000321582_INVS_chr9_103054607_ENST00000262457_length(amino acids)=702AA_BP=326
MFLLPVPRLTSPTRAQSALPLLLATPSSAPSRSSASAGWAGPGGSLPSSNMAAAASVTGRVTWAASPMRSLGLGRRLSLPGPRLDAVTAA
VNPSLSDHGNGLGRGTRGSGCSGGSLVADWGGGAAAAAAVALALAPALSTMRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQ
VRVDAGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVT
VDSSKARTSLDALKISIRQLKWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVE
KSRGETAGDERCAKGKGFVKQPSCIRVAGPDEKGEDSRRAAASLPPHDSHWKPSRRHDTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGS
ARGEAVHAGQNPPHHRTPRNKVTQAKLTGGLYSHLPQSTEELRSGARRLETSTLSEDFQVSKETDPAPGPLSGQSVNIDLLPVELRLQII
QRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQESTALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGT

--------------------------------------------------------------
>95146_95146_3_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000321582_INVS_chr9_103054607_ENST00000541287_length(transcript)=2338nt_BP=1017nt
CGAGTGTTGGCGGGGACTGAGCCTCCTGCTTGAGGTAGTTGTTTTTACTCCCAGTCCCCAGGCTCACGAGCCCCACGCGCGCTCAATCTG
CCCTCCCGCTTCTCCTCGCCACTCCGAGTTCTGCGCCCTCGAGATCCAGCGCATCCGCGGGGTGGGCGGGTCCTGGCGGCTCTTTGCCCT
CTTCCAACATGGCCGCCGCTGCCTCTGTGACAGGCAGGGTCACGTGGGCAGCCTCGCCTATGAGGTCGCTGGGGCTCGGCCGGCGATTGT
CCCTTCCCGGACCCCGTCTCGATGCGGTGACTGCCGCTGTCAACCCGAGCCTGAGCGATCATGGCAACGGGCTCGGGCGGGGAACGCGTG
GCAGCGGCTGCAGCGGCGGCAGTTTGGTGGCGGACTGGGGCGGCGGAGCGGCGGCGGCGGCGGCGGTGGCACTGGCACTGGCCCCGGCCC
TGAGCACCATGCGGCGGGGCAGCTCCGAGAGCGAGCTGGCGGCCCGGTGGGAGGCGGAGGCGGTGGCTGCGGCCAAAGCGGCGGCCAAAG
CTGAGGCCGAGGCCACAGCGGAGACGGTGGCGGAACAGGTCCGCGTGGACGCGGGCGCGGCCGGGGAACCGGAGTGCAAGGCAGGGGAGG
AGCAGCCCAAGGTCCTGGCCCCGGCCCCGGCGCAGCCCAGTGCGGCTGAGGAGGGGAACACCCAGGTCCTTCAGCGGCCGCCGCCCACGC
TGCCCCCGTCCAAGCCGAAGCCGGTGCAGGGCCTCTGCCCGCACGGGAAGCCCCGGGACAAGGGCCGAAGCTGCAAGCGGAGCTCGGGCC
ACGGTTCCGGCGAGAACGGCTCCCAGCGGCCGGTCACCGTGGACAGCTCCAAGGCCAGGACCTCCCTGGATGCCCTGAAGATCAGCATCC
GCCAGCTCAAGTGGAAGGAGTTCCCATTTGGCCGGCGCTTGCCTTGTGACATCTACTGGCATGGAGTTTCATTTCACGACAATGACATAT
TCTCCGGTCAAGTGAACAAGTTTCCAGAAACAGCCAGAGAACATTCTAAAGGCCAATCTGCTTGTGTCCACTTCAGACCCAATGAAGGCA
GTGATGGAAGCAGGCATCCAGGAGTTCCCTCTGTTGAGAAGTCCAGAGGTGAGACAGCTGGCGATGAGCGGTGTGCAAAGGGGAAAGGCT
TCGTGAAGCAGCCCTCCTGTATCAGGGTGGCTGGGCCTGATGAGAAAGGAGAGGACTCCAGGCGGGCAGCTGCAAGCCTTCCACCGCACG
ATAGCCACTGGAAGCCCAGCAGGCGGCATGACACAGAACCCAAGGCCAAATGTGCCCCCCAGAAAAGGCGCACTCAAGAGCTCAGAGGAG
GAAGGTGCTCTCCGGCTGGTTCTAGCCGCCCTGGCAGTGCCCGGGGGGAGGCGGTCCATGCTGGGCAGAATCCTCCCCACCATCGTACAC
CAAGAAACAAAGTGACACAAGCCAAGCTCACAGGAGGGCTCTATTCACATTTGCCACAGAGCACAGAGGAGTTGAGGTCAGGAGCTAGGA
GGCTGGAGACATCTACCCTGTCCGAGGACTTTCAGGTATCTAAGGAGACTGATCCAGCACCTGGTCCCCTCTCTGGGCAGAGTGTGAATA
TTGACCTTCTCCCCGTAGAGCTCCGACTGCAGATAATTCAGAGAGAACGAAGGAGGAAGGAGCTGTTTCGCAAAAAGAACAAGGCAGCAG
CAGTCATCCAGCGCGCCTGGCGAAGCTACCAGCTCAGGAAGCACCTGTCCCACCTTCGGCATATGAAGCAGCTTGGAGCTGGAGATGTGG
ACAGATGGAGGCAAGAGTCTACAGCATTGCTCCTCCAGGTTTGGAGGAAGGAACTGGAACTAAAATTCCCCCAAACCACTGCAGTAAGCA
AGGCCCCCAAGAGTCCATCCAAGGGCACCTCAGGCACAAAGTCCACCAAGCACTCAGTGCTTAAGCAAATCTATGGTTGTTCTCACGAAG
GGAAAATACATCATCCTACAAGATCTGTAAAAGCCTCTTCTGTGCTGCGTCTCAACTCAGGTAAGGCAGCCACTGCAAAGCAGATGGTGG
GGAAGAACATGGGGAAGCATTTTCCTTTGTTTCATCCCCAAAGACAGAAGACATTAGAACAGATATGGCCAGGGTTTTCCAATGGTCATT
TGATTTCATGGGATTATTACTGTAGCCAACATCTGTCTCCCTAAGAGGCAAATTATTTTCACAACTAAAAGCTATTATTGTTAACATTAA

>95146_95146_3_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000321582_INVS_chr9_103054607_ENST00000541287_length(amino acids)=721AA_BP=326
MFLLPVPRLTSPTRAQSALPLLLATPSSAPSRSSASAGWAGPGGSLPSSNMAAAASVTGRVTWAASPMRSLGLGRRLSLPGPRLDAVTAA
VNPSLSDHGNGLGRGTRGSGCSGGSLVADWGGGAAAAAAVALALAPALSTMRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQ
VRVDAGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVT
VDSSKARTSLDALKISIRQLKWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVE
KSRGETAGDERCAKGKGFVKQPSCIRVAGPDEKGEDSRRAAASLPPHDSHWKPSRRHDTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGS
ARGEAVHAGQNPPHHRTPRNKVTQAKLTGGLYSHLPQSTEELRSGARRLETSTLSEDFQVSKETDPAPGPLSGQSVNIDLLPVELRLQII
QRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQESTALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGT
KSTKHSVLKQIYGCSHEGKIHHPTRSVKASSVLRLNSGKAATAKQMVGKNMGKHFPLFHPQRQKTLEQIWPGFSNGHLISWDYYCSQHLS

--------------------------------------------------------------
>95146_95146_4_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000373776_INVS_chr9_103054607_ENST00000262456_length(transcript)=1751nt_BP=1017nt
CGAGTGTTGGCGGGGACTGAGCCTCCTGCTTGAGGTAGTTGTTTTTACTCCCAGTCCCCAGGCTCACGAGCCCCACGCGCGCTCAATCTG
CCCTCCCGCTTCTCCTCGCCACTCCGAGTTCTGCGCCCTCGAGATCCAGCGCATCCGCGGGGTGGGCGGGTCCTGGCGGCTCTTTGCCCT
CTTCCAACATGGCCGCCGCTGCCTCTGTGACAGGCAGGGTCACGTGGGCAGCCTCGCCTATGAGGTCGCTGGGGCTCGGCCGGCGATTGT
CCCTTCCCGGACCCCGTCTCGATGCGGTGACTGCCGCTGTCAACCCGAGCCTGAGCGATCATGGCAACGGGCTCGGGCGGGGAACGCGTG
GCAGCGGCTGCAGCGGCGGCAGTTTGGTGGCGGACTGGGGCGGCGGAGCGGCGGCGGCGGCGGCGGTGGCACTGGCACTGGCCCCGGCCC
TGAGCACCATGCGGCGGGGCAGCTCCGAGAGCGAGCTGGCGGCCCGGTGGGAGGCGGAGGCGGTGGCTGCGGCCAAAGCGGCGGCCAAAG
CTGAGGCCGAGGCCACAGCGGAGACGGTGGCGGAACAGGTCCGCGTGGACGCGGGCGCGGCCGGGGAACCGGAGTGCAAGGCAGGGGAGG
AGCAGCCCAAGGTCCTGGCCCCGGCCCCGGCGCAGCCCAGTGCGGCTGAGGAGGGGAACACCCAGGTCCTTCAGCGGCCGCCGCCCACGC
TGCCCCCGTCCAAGCCGAAGCCGGTGCAGGGCCTCTGCCCGCACGGGAAGCCCCGGGACAAGGGCCGAAGCTGCAAGCGGAGCTCGGGCC
ACGGTTCCGGCGAGAACGGCTCCCAGCGGCCGGTCACCGTGGACAGCTCCAAGGCCAGGACCTCCCTGGATGCCCTGAAGATCAGCATCC
GCCAGCTCAAGTGGAAGGAGTTCCCATTTGGCCGGCGCTTGCCTTGTGACATCTACTGGCATGGAGTTTCATTTCACGACAATGACATAT
TCTCCGGTCAAGTGAACAAGTTTCCAGAAACAGCCAGAGAACATTCTAAAGGCCAATCTGCTTGTGTCCACTTCAGACCCAATGAAGGCA
GTGATGGAAGCAGGCATCCAGGAGTTCCCTCTGTTGAGAAGTCCAGAGAGCTCCGACTGCAGATAATTCAGAGAGAACGAAGGAGGAAGG
AGCTGTTTCGCAAAAAGAACAAGGCAGCAGCAGTCATCCAGCGCGCCTGGCGAAGCTACCAGCTCAGGAAGCACCTGTCCCACCTTCGGC
ATATGAAGCAGCTTGGAGCTGGAGATGTGGACAGATGGAGGCAAGAGTCTACAGCATTGCTCCTCCAGGTTTGGAGGAAGGAACTGGAAC
TAAAATTCCCCCAAACCACTGCAGTAAGCAAGGCCCCCAAGAGTCCATCCAAGGGCACCTCAGGCACAAAGTCCACCAAGCACTCAGTGC
TTAAGCAAATCTATGGTTGTTCTCACGAAGGGAAAATACATCATCCTACAAGATCTGTAAAAGCCTCTTCTGTGCTGCGTCTCAACTCAG
TGAGCAACCTACAGTGTATACATCTCCTTGAGAACAGTGGAAGATCAAAGAACTTTTCTTATAACCTGCAATCAGCTACTCAGCCAAAAA
ACAAAACAAAACCTTGACTGCCTATGGAGGAAGACTGTGTTCGGGGGAGCTGGCATAGCTAGTGCAGAGTTCAGATTTTCTGCTGATAAT

>95146_95146_4_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000373776_INVS_chr9_103054607_ENST00000262456_length(amino acids)=532AA_BP=326
MFLLPVPRLTSPTRAQSALPLLLATPSSAPSRSSASAGWAGPGGSLPSSNMAAAASVTGRVTWAASPMRSLGLGRRLSLPGPRLDAVTAA
VNPSLSDHGNGLGRGTRGSGCSGGSLVADWGGGAAAAAAVALALAPALSTMRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQ
VRVDAGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVT
VDSSKARTSLDALKISIRQLKWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVE
KSRELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQESTALLLQVWRKELELKFPQTTAVSKAP

--------------------------------------------------------------
>95146_95146_5_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000373776_INVS_chr9_103054607_ENST00000262457_length(transcript)=2473nt_BP=1017nt
CGAGTGTTGGCGGGGACTGAGCCTCCTGCTTGAGGTAGTTGTTTTTACTCCCAGTCCCCAGGCTCACGAGCCCCACGCGCGCTCAATCTG
CCCTCCCGCTTCTCCTCGCCACTCCGAGTTCTGCGCCCTCGAGATCCAGCGCATCCGCGGGGTGGGCGGGTCCTGGCGGCTCTTTGCCCT
CTTCCAACATGGCCGCCGCTGCCTCTGTGACAGGCAGGGTCACGTGGGCAGCCTCGCCTATGAGGTCGCTGGGGCTCGGCCGGCGATTGT
CCCTTCCCGGACCCCGTCTCGATGCGGTGACTGCCGCTGTCAACCCGAGCCTGAGCGATCATGGCAACGGGCTCGGGCGGGGAACGCGTG
GCAGCGGCTGCAGCGGCGGCAGTTTGGTGGCGGACTGGGGCGGCGGAGCGGCGGCGGCGGCGGCGGTGGCACTGGCACTGGCCCCGGCCC
TGAGCACCATGCGGCGGGGCAGCTCCGAGAGCGAGCTGGCGGCCCGGTGGGAGGCGGAGGCGGTGGCTGCGGCCAAAGCGGCGGCCAAAG
CTGAGGCCGAGGCCACAGCGGAGACGGTGGCGGAACAGGTCCGCGTGGACGCGGGCGCGGCCGGGGAACCGGAGTGCAAGGCAGGGGAGG
AGCAGCCCAAGGTCCTGGCCCCGGCCCCGGCGCAGCCCAGTGCGGCTGAGGAGGGGAACACCCAGGTCCTTCAGCGGCCGCCGCCCACGC
TGCCCCCGTCCAAGCCGAAGCCGGTGCAGGGCCTCTGCCCGCACGGGAAGCCCCGGGACAAGGGCCGAAGCTGCAAGCGGAGCTCGGGCC
ACGGTTCCGGCGAGAACGGCTCCCAGCGGCCGGTCACCGTGGACAGCTCCAAGGCCAGGACCTCCCTGGATGCCCTGAAGATCAGCATCC
GCCAGCTCAAGTGGAAGGAGTTCCCATTTGGCCGGCGCTTGCCTTGTGACATCTACTGGCATGGAGTTTCATTTCACGACAATGACATAT
TCTCCGGTCAAGTGAACAAGTTTCCAGAAACAGCCAGAGAACATTCTAAAGGCCAATCTGCTTGTGTCCACTTCAGACCCAATGAAGGCA
GTGATGGAAGCAGGCATCCAGGAGTTCCCTCTGTTGAGAAGTCCAGAGGTGAGACAGCTGGCGATGAGCGGTGTGCAAAGGGGAAAGGCT
TCGTGAAGCAGCCCTCCTGTATCAGGGTGGCTGGGCCTGATGAGAAAGGAGAGGACTCCAGGCGGGCAGCTGCAAGCCTTCCACCGCACG
ATAGCCACTGGAAGCCCAGCAGGCGGCATGACACAGAACCCAAGGCCAAATGTGCCCCCCAGAAAAGGCGCACTCAAGAGCTCAGAGGAG
GAAGGTGCTCTCCGGCTGGTTCTAGCCGCCCTGGCAGTGCCCGGGGGGAGGCGGTCCATGCTGGGCAGAATCCTCCCCACCATCGTACAC
CAAGAAACAAAGTGACACAAGCCAAGCTCACAGGAGGGCTCTATTCACATTTGCCACAGAGCACAGAGGAGTTGAGGTCAGGAGCTAGGA
GGCTGGAGACATCTACCCTGTCCGAGGACTTTCAGGTATCTAAGGAGACTGATCCAGCACCTGGTCCCCTCTCTGGGCAGAGTGTGAATA
TTGACCTTCTCCCCGTAGAGCTCCGACTGCAGATAATTCAGAGAGAACGAAGGAGGAAGGAGCTGTTTCGCAAAAAGAACAAGGCAGCAG
CAGTCATCCAGCGCGCCTGGCGAAGCTACCAGCTCAGGAAGCACCTGTCCCACCTTCGGCATATGAAGCAGCTTGGAGCTGGAGATGTGG
ACAGATGGAGGCAAGAGTCTACAGCATTGCTCCTCCAGGTTTGGAGGAAGGAACTGGAACTAAAATTCCCCCAAACCACTGCAGTAAGCA
AGGCCCCCAAGAGTCCATCCAAGGGCACCTCAGGCACAAAGTCCACCAAGCACTCAGTGCTTAAGCAAATCTATGGTTGTTCTCACGAAG
GGAAAATACATCATCCTACAAGATCTGTAAAAGCCTCTTCTGTGCTGCGTCTCAACTCAGTGAGCAACCTACAGTGTATACATCTCCTTG
AGAACAGTGGAAGATCAAAGAACTTTTCTTATAACCTGCAATCAGCTACTCAGCCAAAAAACAAAACAAAACCTTGACTGCCTATGGAGG
AAGACTGTGTTCGGGGGAGCTGGCATAGCTAGTGCAGAGTTCAGATTTTCTGCTGATAATCTTTTACACCTTGGGAAAACTTTAATATCC
GTACCTGAAGGCTGATTCACCTAAAAATGTGTTAACTGAAAGAAAATGTCAGAATGTTTCCTTTCTGCTCTTACACAGCATTGTTTTGTC
AATCAACACAGCCTGCACTGAAAGGACCTGCATAGACTATGTCTGTGCAAAGTGCCTGAGTGTCTGCTTTCACCTCAGTCTGTACAGTTG

>95146_95146_5_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000373776_INVS_chr9_103054607_ENST00000262457_length(amino acids)=702AA_BP=326
MFLLPVPRLTSPTRAQSALPLLLATPSSAPSRSSASAGWAGPGGSLPSSNMAAAASVTGRVTWAASPMRSLGLGRRLSLPGPRLDAVTAA
VNPSLSDHGNGLGRGTRGSGCSGGSLVADWGGGAAAAAAVALALAPALSTMRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQ
VRVDAGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVT
VDSSKARTSLDALKISIRQLKWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVE
KSRGETAGDERCAKGKGFVKQPSCIRVAGPDEKGEDSRRAAASLPPHDSHWKPSRRHDTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGS
ARGEAVHAGQNPPHHRTPRNKVTQAKLTGGLYSHLPQSTEELRSGARRLETSTLSEDFQVSKETDPAPGPLSGQSVNIDLLPVELRLQII
QRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQESTALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGT

--------------------------------------------------------------
>95146_95146_6_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000373776_INVS_chr9_103054607_ENST00000541287_length(transcript)=2338nt_BP=1017nt
CGAGTGTTGGCGGGGACTGAGCCTCCTGCTTGAGGTAGTTGTTTTTACTCCCAGTCCCCAGGCTCACGAGCCCCACGCGCGCTCAATCTG
CCCTCCCGCTTCTCCTCGCCACTCCGAGTTCTGCGCCCTCGAGATCCAGCGCATCCGCGGGGTGGGCGGGTCCTGGCGGCTCTTTGCCCT
CTTCCAACATGGCCGCCGCTGCCTCTGTGACAGGCAGGGTCACGTGGGCAGCCTCGCCTATGAGGTCGCTGGGGCTCGGCCGGCGATTGT
CCCTTCCCGGACCCCGTCTCGATGCGGTGACTGCCGCTGTCAACCCGAGCCTGAGCGATCATGGCAACGGGCTCGGGCGGGGAACGCGTG
GCAGCGGCTGCAGCGGCGGCAGTTTGGTGGCGGACTGGGGCGGCGGAGCGGCGGCGGCGGCGGCGGTGGCACTGGCACTGGCCCCGGCCC
TGAGCACCATGCGGCGGGGCAGCTCCGAGAGCGAGCTGGCGGCCCGGTGGGAGGCGGAGGCGGTGGCTGCGGCCAAAGCGGCGGCCAAAG
CTGAGGCCGAGGCCACAGCGGAGACGGTGGCGGAACAGGTCCGCGTGGACGCGGGCGCGGCCGGGGAACCGGAGTGCAAGGCAGGGGAGG
AGCAGCCCAAGGTCCTGGCCCCGGCCCCGGCGCAGCCCAGTGCGGCTGAGGAGGGGAACACCCAGGTCCTTCAGCGGCCGCCGCCCACGC
TGCCCCCGTCCAAGCCGAAGCCGGTGCAGGGCCTCTGCCCGCACGGGAAGCCCCGGGACAAGGGCCGAAGCTGCAAGCGGAGCTCGGGCC
ACGGTTCCGGCGAGAACGGCTCCCAGCGGCCGGTCACCGTGGACAGCTCCAAGGCCAGGACCTCCCTGGATGCCCTGAAGATCAGCATCC
GCCAGCTCAAGTGGAAGGAGTTCCCATTTGGCCGGCGCTTGCCTTGTGACATCTACTGGCATGGAGTTTCATTTCACGACAATGACATAT
TCTCCGGTCAAGTGAACAAGTTTCCAGAAACAGCCAGAGAACATTCTAAAGGCCAATCTGCTTGTGTCCACTTCAGACCCAATGAAGGCA
GTGATGGAAGCAGGCATCCAGGAGTTCCCTCTGTTGAGAAGTCCAGAGGTGAGACAGCTGGCGATGAGCGGTGTGCAAAGGGGAAAGGCT
TCGTGAAGCAGCCCTCCTGTATCAGGGTGGCTGGGCCTGATGAGAAAGGAGAGGACTCCAGGCGGGCAGCTGCAAGCCTTCCACCGCACG
ATAGCCACTGGAAGCCCAGCAGGCGGCATGACACAGAACCCAAGGCCAAATGTGCCCCCCAGAAAAGGCGCACTCAAGAGCTCAGAGGAG
GAAGGTGCTCTCCGGCTGGTTCTAGCCGCCCTGGCAGTGCCCGGGGGGAGGCGGTCCATGCTGGGCAGAATCCTCCCCACCATCGTACAC
CAAGAAACAAAGTGACACAAGCCAAGCTCACAGGAGGGCTCTATTCACATTTGCCACAGAGCACAGAGGAGTTGAGGTCAGGAGCTAGGA
GGCTGGAGACATCTACCCTGTCCGAGGACTTTCAGGTATCTAAGGAGACTGATCCAGCACCTGGTCCCCTCTCTGGGCAGAGTGTGAATA
TTGACCTTCTCCCCGTAGAGCTCCGACTGCAGATAATTCAGAGAGAACGAAGGAGGAAGGAGCTGTTTCGCAAAAAGAACAAGGCAGCAG
CAGTCATCCAGCGCGCCTGGCGAAGCTACCAGCTCAGGAAGCACCTGTCCCACCTTCGGCATATGAAGCAGCTTGGAGCTGGAGATGTGG
ACAGATGGAGGCAAGAGTCTACAGCATTGCTCCTCCAGGTTTGGAGGAAGGAACTGGAACTAAAATTCCCCCAAACCACTGCAGTAAGCA
AGGCCCCCAAGAGTCCATCCAAGGGCACCTCAGGCACAAAGTCCACCAAGCACTCAGTGCTTAAGCAAATCTATGGTTGTTCTCACGAAG
GGAAAATACATCATCCTACAAGATCTGTAAAAGCCTCTTCTGTGCTGCGTCTCAACTCAGGTAAGGCAGCCACTGCAAAGCAGATGGTGG
GGAAGAACATGGGGAAGCATTTTCCTTTGTTTCATCCCCAAAGACAGAAGACATTAGAACAGATATGGCCAGGGTTTTCCAATGGTCATT
TGATTTCATGGGATTATTACTGTAGCCAACATCTGTCTCCCTAAGAGGCAAATTATTTTCACAACTAAAAGCTATTATTGTTAACATTAA

>95146_95146_6_TTLL11-INVS_TTLL11_chr9_124801550_ENST00000373776_INVS_chr9_103054607_ENST00000541287_length(amino acids)=721AA_BP=326
MFLLPVPRLTSPTRAQSALPLLLATPSSAPSRSSASAGWAGPGGSLPSSNMAAAASVTGRVTWAASPMRSLGLGRRLSLPGPRLDAVTAA
VNPSLSDHGNGLGRGTRGSGCSGGSLVADWGGGAAAAAAVALALAPALSTMRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQ
VRVDAGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVT
VDSSKARTSLDALKISIRQLKWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVE
KSRGETAGDERCAKGKGFVKQPSCIRVAGPDEKGEDSRRAAASLPPHDSHWKPSRRHDTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGS
ARGEAVHAGQNPPHHRTPRNKVTQAKLTGGLYSHLPQSTEELRSGARRLETSTLSEDFQVSKETDPAPGPLSGQSVNIDLLPVELRLQII
QRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQESTALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGT
KSTKHSVLKQIYGCSHEGKIHHPTRSVKASSVLRLNSGKAATAKQMVGKNMGKHFPLFHPQRQKTLEQIWPGFSNGHLISWDYYCSQHLS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TTLL11-INVS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TTLL11-INVS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TTLL11-INVS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource