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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTYH3-EIF3B (FusionGDB2 ID:95258)

Fusion Gene Summary for TTYH3-EIF3B

check button Fusion gene summary
Fusion gene informationFusion gene name: TTYH3-EIF3B
Fusion gene ID: 95258
HgeneTgene
Gene symbol

TTYH3

EIF3B

Gene ID

80727

8662

Gene nametweety family member 3eukaryotic translation initiation factor 3 subunit B
Synonyms-EIF3-ETA|EIF3-P110|EIF3-P116|EIF3S9|PRT1
Cytomap

7p22.3

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionprotein tweety homolog 3hTTY3tweety homolog 3eukaryotic translation initiation factor 3 subunit Beukaryotic translation initiation factor 3 subunit 9eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)eukaryotic translation initiation factor 3, subunit 9 eta, 116kDaprt1 homolog
Modification date2020031320200322
UniProtAcc.

P55884

Ensembl transtripts involved in fusion geneENST00000258796, ENST00000407643, 
ENST00000403167, ENST00000477439, 
ENST00000360876, ENST00000397011, 
Fusion gene scores* DoF score14 X 12 X 7=117616 X 22 X 8=2816
# samples 1822
** MAII scorelog2(18/1176*10)=-2.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2816*10)=-3.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTYH3 [Title/Abstract] AND EIF3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTYH3(2671912)-EIF3B(2418324), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTYH3

GO:0006821

chloride transport

16219661

TgeneEIF3B

GO:0006413

translational initiation

8995410|17581632

TgeneEIF3B

GO:0006446

regulation of translational initiation

8995410

TgeneEIF3B

GO:0075522

IRES-dependent viral translational initiation

9573242

TgeneEIF3B

GO:0075525

viral translational termination-reinitiation

21347434


check buttonFusion gene breakpoints across TTYH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-WZ-A8D5-01ATTYH3chr7

2671912

+EIF3Bchr7

2418324

+


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Fusion Gene ORF analysis for TTYH3-EIF3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000258796ENST00000360876TTYH3chr7

2671912

+EIF3Bchr7

2418324

+
In-frameENST00000258796ENST00000397011TTYH3chr7

2671912

+EIF3Bchr7

2418324

+
In-frameENST00000407643ENST00000360876TTYH3chr7

2671912

+EIF3Bchr7

2418324

+
In-frameENST00000407643ENST00000397011TTYH3chr7

2671912

+EIF3Bchr7

2418324

+
intron-3CDSENST00000403167ENST00000360876TTYH3chr7

2671912

+EIF3Bchr7

2418324

+
intron-3CDSENST00000403167ENST00000397011TTYH3chr7

2671912

+EIF3Bchr7

2418324

+
intron-3CDSENST00000477439ENST00000360876TTYH3chr7

2671912

+EIF3Bchr7

2418324

+
intron-3CDSENST00000477439ENST00000397011TTYH3chr7

2671912

+EIF3Bchr7

2418324

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258796TTYH3chr72671912+ENST00000360876EIF3Bchr72418324+11733281114593173
ENST00000258796TTYH3chr72671912+ENST00000397011EIF3Bchr72418324+11003281039593148
ENST00000407643TTYH3chr72671912+ENST00000360876EIF3Bchr72418324+968123909388173
ENST00000407643TTYH3chr72671912+ENST00000397011EIF3Bchr72418324+895123834388148

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258796ENST00000360876TTYH3chr72671912+EIF3Bchr72418324+0.0070300660.99296993
ENST00000258796ENST00000397011TTYH3chr72671912+EIF3Bchr72418324+0.0082511280.9917489
ENST00000407643ENST00000360876TTYH3chr72671912+EIF3Bchr72418324+0.0109869380.9890131
ENST00000407643ENST00000397011TTYH3chr72671912+EIF3Bchr72418324+0.006603790.9933962

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Fusion Genomic Features for TTYH3-EIF3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TTYH3chr72671912+EIF3Bchr72418323+0.0008572270.99914277
TTYH3chr72671912+EIF3Bchr72418323+0.0008572270.99914277

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TTYH3-EIF3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:2671912/chr7:2418324)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF3B

P55884

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+1141_4241524.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+1131_4241492.0Topological domainExtracellular

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+114108_21141524.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+114233_23641524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+114258_38641524.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+114408_52341524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+11464_8641524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+110108_2110353.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+1101_420353.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+110233_2360353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+110258_3860353.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+110408_5230353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+11064_860353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+113108_21141492.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+113233_23641492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+113258_38641492.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+113408_52341492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+11364_8641492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+114212_23241524.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+114237_25741524.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+114387_40741524.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+11443_6341524.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:2418324ENST00000258796+11487_10741524.0TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+110212_2320353.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+110237_2570353.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+110387_4070353.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+11043_630353.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:2418324ENST00000403167+11087_1070353.0TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+113212_23241492.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+113237_25741492.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+113387_40741492.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+11343_6341492.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:2418324ENST00000407643+11387_10741492.0TransmembraneHelical%3B Name%3D2
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003608761419185_268718810.0DomainRRM
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003970111419185_268718791.0DomainRRM
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003608761419285_324718810.0RepeatNote=WD 1
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003608761419325_365718810.0RepeatNote=WD 2
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003608761419366_425718810.0RepeatNote=WD 3
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003608761419426_489718810.0RepeatNote=WD 4
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003608761419490_553718810.0RepeatNote=WD 5
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003608761419554_598718810.0RepeatNote=WD 6
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003608761419599_642718810.0RepeatNote=WD 7
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003608761419643_685718810.0RepeatNote=WD 8
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003970111419285_324718791.0RepeatNote=WD 1
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003970111419325_365718791.0RepeatNote=WD 2
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003970111419366_425718791.0RepeatNote=WD 3
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003970111419426_489718791.0RepeatNote=WD 4
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003970111419490_553718791.0RepeatNote=WD 5
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003970111419554_598718791.0RepeatNote=WD 6
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003970111419599_642718791.0RepeatNote=WD 7
TgeneEIF3Bchr7:2671912chr7:2418324ENST000003970111419643_685718791.0RepeatNote=WD 8


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Fusion Gene Sequence for TTYH3-EIF3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95258_95258_1_TTYH3-EIF3B_TTYH3_chr7_2671912_ENST00000258796_EIF3B_chr7_2418324_ENST00000360876_length(transcript)=1173nt_BP=328nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGCAAATTAAAAAGGATCTGAAGAAATACTCTAA
GATCTTTGAACAGAAGGATCGTTTGAGTCAGTCCAAAGCCTCAAAGGAATTGGTGGAGAGAAGGCGCACCATGATGGAAGATTTCCGGAA
GTACCGGAAAATGGCCCAGGAGCTCTATATGGAGCAGAAAAACGAGCGCCTGGAGTTGCGAGGAGGGGTGGACACTGACGAGCTGGACAG
CAACGTGGACGACTGGGAAGAGGAGACCATTGAGTTCTTCGTCACTGAAGAAATCATTCCCCTCGGGAATCAGGAGTGACCTGGAGCACT
GTGGGGACGGACTCCGCCTGCTGTTCCCGCGCTGAGCTACAGGACTCCCGAGTGTGAGCCGCGGTTCCTCTGTTGCAGCGCAGCCGTGTG
TGCTGTGGAGCCGAGGCCGTCCTGCAGGAAGCCGCGTGACTCCCGCCTCCTCCCTGTGCTCTCTGGCTCTGGACTGTGACTGCGCCTGGA
TTCTGCCATTGCGACACATTTTTGTGCCTTTCAGCCCCTGGTGTCTGCAGTGGGGGATTTAAGGCACCCGCTTCCACTTCTTTCTTGTTT
GGAGTTTTCTGTTGGAACCGCCGGCGTTGGCTCCGAAGACTTAGCGACGCCACTGGCGGCACCTTCTCCTGCGCCCAGTGATGTTTCCAC
GGTGCCTGTACACAGCCGAGCAGCATTTCCGTTGAAGGACTTGCATCCCCATTGCGGGCAGTGCTGGACGTGTCCCGGAGACCCACCGGG
AGGGCGCCGCCATGCCTTGTACCCCCACCGTGCAGGTTGTGGCCGGTTTTCTCCGCAGGTTGAACATGGAAATAAAAGCAAACTTGTATG

>95258_95258_1_TTYH3-EIF3B_TTYH3_chr7_2671912_ENST00000258796_EIF3B_chr7_2418324_ENST00000360876_length(amino acids)=173AA_BP=
MHGGGTRHGGALPVGLRDTSSTARNGDASPSTEMLLGCVQAPWKHHWAQEKVPPVASLSLRSQRRRFQQKTPNKKEVEAGALNPPLQTPG

--------------------------------------------------------------
>95258_95258_2_TTYH3-EIF3B_TTYH3_chr7_2671912_ENST00000258796_EIF3B_chr7_2418324_ENST00000397011_length(transcript)=1100nt_BP=328nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGCAAATTAAAAAGGATCTGAAGAAATACTCTAA
GATCTTTGAACAGAAGGATCGTTTGAGTCAGTCCAAAGCCTCAAAGGAATTGGTGGAGAGAAGGCGCACCATGATGGAAGATTTCCGGAA
GTACCGGAAAATGGCCCAGGAGCTCTATATGGAGCAGAAAAACGAGCGCCTGGAGTTGCGAGGAGGGGTGGACACTGACGAGCTGGACAG
CAACGTGGACGACTGGGAAGAGGAGACCATTGAGTTCTTCGTCACTGAAGAAATCATTCCCCTCGGGAATCAGGAGTGACCTGGAGCACT
GTGCGCAGCCGTGTGTGCTGTGGAGCCGAGGCCGTCCTGCAGGAAGCCGCGTGACTCCCGCCTCCTCCCTGTGCTCTCTGGCTCTGGACT
GTGACTGCGCCTGGATTCTGCCATTGCGACACATTTTTGTGCCTTTCAGCCCCTGGTGTCTGCAGTGGGGGATTTAAGGCACCCGCTTCC
ACTTCTTTCTTGTTTGGAGTTTTCTGTTGGAACCGCCGGCGTTGGCTCCGAAGACTTAGCGACGCCACTGGCGGCACCTTCTCCTGCGCC
CAGTGATGTTTCCACGGTGCCTGTACACAGCCGAGCAGCATTTCCGTTGAAGGACTTGCATCCCCATTGCGGGCAGTGCTGGACGTGTCC
CGGAGACCCACCGGGAGGGCGCCGCCATGCCTTGTACCCCCACCGTGCAGGTTGTGGCCGGTTTTCTCCGCAGGTTGAACATGGAAATAA

>95258_95258_2_TTYH3-EIF3B_TTYH3_chr7_2671912_ENST00000258796_EIF3B_chr7_2418324_ENST00000397011_length(amino acids)=148AA_BP=
MHGGGTRHGGALPVGLRDTSSTARNGDASPSTEMLLGCVQAPWKHHWAQEKVPPVASLSLRSQRRRFQQKTPNKKEVEAGALNPPLQTPG

--------------------------------------------------------------
>95258_95258_3_TTYH3-EIF3B_TTYH3_chr7_2671912_ENST00000407643_EIF3B_chr7_2418324_ENST00000360876_length(transcript)=968nt_BP=123nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGCAAATTAAAAAGGATCTGAAGAAATACTCTAAGATCTTTGAACAGAAGGATCGTTTG
AGTCAGTCCAAAGCCTCAAAGGAATTGGTGGAGAGAAGGCGCACCATGATGGAAGATTTCCGGAAGTACCGGAAAATGGCCCAGGAGCTC
TATATGGAGCAGAAAAACGAGCGCCTGGAGTTGCGAGGAGGGGTGGACACTGACGAGCTGGACAGCAACGTGGACGACTGGGAAGAGGAG
ACCATTGAGTTCTTCGTCACTGAAGAAATCATTCCCCTCGGGAATCAGGAGTGACCTGGAGCACTGTGGGGACGGACTCCGCCTGCTGTT
CCCGCGCTGAGCTACAGGACTCCCGAGTGTGAGCCGCGGTTCCTCTGTTGCAGCGCAGCCGTGTGTGCTGTGGAGCCGAGGCCGTCCTGC
AGGAAGCCGCGTGACTCCCGCCTCCTCCCTGTGCTCTCTGGCTCTGGACTGTGACTGCGCCTGGATTCTGCCATTGCGACACATTTTTGT
GCCTTTCAGCCCCTGGTGTCTGCAGTGGGGGATTTAAGGCACCCGCTTCCACTTCTTTCTTGTTTGGAGTTTTCTGTTGGAACCGCCGGC
GTTGGCTCCGAAGACTTAGCGACGCCACTGGCGGCACCTTCTCCTGCGCCCAGTGATGTTTCCACGGTGCCTGTACACAGCCGAGCAGCA
TTTCCGTTGAAGGACTTGCATCCCCATTGCGGGCAGTGCTGGACGTGTCCCGGAGACCCACCGGGAGGGCGCCGCCATGCCTTGTACCCC

>95258_95258_3_TTYH3-EIF3B_TTYH3_chr7_2671912_ENST00000407643_EIF3B_chr7_2418324_ENST00000360876_length(amino acids)=173AA_BP=
MHGGGTRHGGALPVGLRDTSSTARNGDASPSTEMLLGCVQAPWKHHWAQEKVPPVASLSLRSQRRRFQQKTPNKKEVEAGALNPPLQTPG

--------------------------------------------------------------
>95258_95258_4_TTYH3-EIF3B_TTYH3_chr7_2671912_ENST00000407643_EIF3B_chr7_2418324_ENST00000397011_length(transcript)=895nt_BP=123nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGCAAATTAAAAAGGATCTGAAGAAATACTCTAAGATCTTTGAACAGAAGGATCGTTTG
AGTCAGTCCAAAGCCTCAAAGGAATTGGTGGAGAGAAGGCGCACCATGATGGAAGATTTCCGGAAGTACCGGAAAATGGCCCAGGAGCTC
TATATGGAGCAGAAAAACGAGCGCCTGGAGTTGCGAGGAGGGGTGGACACTGACGAGCTGGACAGCAACGTGGACGACTGGGAAGAGGAG
ACCATTGAGTTCTTCGTCACTGAAGAAATCATTCCCCTCGGGAATCAGGAGTGACCTGGAGCACTGTGCGCAGCCGTGTGTGCTGTGGAG
CCGAGGCCGTCCTGCAGGAAGCCGCGTGACTCCCGCCTCCTCCCTGTGCTCTCTGGCTCTGGACTGTGACTGCGCCTGGATTCTGCCATT
GCGACACATTTTTGTGCCTTTCAGCCCCTGGTGTCTGCAGTGGGGGATTTAAGGCACCCGCTTCCACTTCTTTCTTGTTTGGAGTTTTCT
GTTGGAACCGCCGGCGTTGGCTCCGAAGACTTAGCGACGCCACTGGCGGCACCTTCTCCTGCGCCCAGTGATGTTTCCACGGTGCCTGTA
CACAGCCGAGCAGCATTTCCGTTGAAGGACTTGCATCCCCATTGCGGGCAGTGCTGGACGTGTCCCGGAGACCCACCGGGAGGGCGCCGC

>95258_95258_4_TTYH3-EIF3B_TTYH3_chr7_2671912_ENST00000407643_EIF3B_chr7_2418324_ENST00000397011_length(amino acids)=148AA_BP=
MHGGGTRHGGALPVGLRDTSSTARNGDASPSTEMLLGCVQAPWKHHWAQEKVPPVASLSLRSQRRRFQQKTPNKKEVEAGALNPPLQTPG

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Fusion Gene PPI Analysis for TTYH3-EIF3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTYH3-EIF3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTYH3-EIF3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource