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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTYH3-MAD1L1 (FusionGDB2 ID:95260)

Fusion Gene Summary for TTYH3-MAD1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: TTYH3-MAD1L1
Fusion gene ID: 95260
HgeneTgene
Gene symbol

TTYH3

MAD1L1

Gene ID

80727

8379

Gene nametweety family member 3mitotic arrest deficient 1 like 1
Synonyms-MAD1|PIG9|TP53I9|TXBP181
Cytomap

7p22.3

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionprotein tweety homolog 3hTTY3tweety homolog 3mitotic spindle assembly checkpoint protein MAD1MAD1 mitotic arrest deficient like 1MAD1-like protein 1mitotic arrest deficient 1-like protein 1mitotic checkpoint MAD1 protein homologmitotic-arrest deficient 1, yeast, homolog-like 1tax-binding prote
Modification date2020031320200313
UniProtAcc.

Q9Y6D9

Ensembl transtripts involved in fusion geneENST00000258796, ENST00000407643, 
ENST00000403167, ENST00000477439, 
ENST00000486340, ENST00000265854, 
ENST00000399654, ENST00000402746, 
ENST00000406869, 
Fusion gene scores* DoF score14 X 12 X 7=117623 X 16 X 12=4416
# samples 1837
** MAII scorelog2(18/1176*10)=-2.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(37/4416*10)=-3.57714299626186
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTYH3 [Title/Abstract] AND MAD1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTYH3(2671912)-MAD1L1(1855864), # samples:5
TTYH3(2671912)-MAD1L1(1938026), # samples:5
Anticipated loss of major functional domain due to fusion event.TTYH3-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TTYH3-MAD1L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TTYH3-MAD1L1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTYH3

GO:0006821

chloride transport

16219661

TgeneMAD1L1

GO:0007094

mitotic spindle assembly checkpoint

18981471

TgeneMAD1L1

GO:0090235

regulation of metaphase plate congression

20133940


check buttonFusion gene breakpoints across TTYH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAD1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2811-03BTTYH3chr7

2671912

-MAD1L1chr7

1938026

-
ChimerDB4SKCMTCGA-3N-A9WD-06ATTYH3chr7

2671912

-MAD1L1chr7

1938026

-
ChimerDB4SKCMTCGA-3N-A9WD-06ATTYH3chr7

2671912

+MAD1L1chr7

1938026

-
ChimerDB4SKCMTCGA-BF-A3DL-01ATTYH3chr7

2671912

+MAD1L1chr7

1855864

-
ChimerDB4SKCMTCGA-BF-A3DL-01ATTYH3chr7

2671912

+MAD1L1chr7

2020176

-
ChimerDB4SKCMTCGA-BF-A3DLTTYH3chr7

2671912

+MAD1L1chr7

1855864

-
ChimerDB4SKCMTCGA-D9-A6EA-06ATTYH3chr7

2671912

+MAD1L1chr7

1855864

-
ChimerDB4SKCMTCGA-EE-A2A1-06ATTYH3chr7

2671912

+MAD1L1chr7

1938026

-
ChimerDB4SKCMTCGA-FS-A1YW-06ATTYH3chr7

2686656

-MAD1L1chr7

1976533

-
ChimerDB4SKCMTCGA-FS-A1YW-06ATTYH3chr7

2686656

+MAD1L1chr7

1976533

-
ChimerDB4SKCMTCGA-FS-A1YW-06ATTYH3chr7

2686887

+MAD1L1chr7

1976533

-
ChimerDB4SKCMTCGA-Z2-AA3V-06ATTYH3chr7

2671912

-MAD1L1chr7

1855864

-
ChimerDB4SKCMTCGA-Z2-AA3VTTYH3chr7

2671912

+MAD1L1chr7

1855864

-
ChimerDB4SKCMTCGA-Z2-AA3VTTYH3chr7

2671912

+MAD1L1chr7

1938026

-


Top

Fusion Gene ORF analysis for TTYH3-MAD1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000258796ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
5CDS-intronENST00000258796ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
5CDS-intronENST00000258796ENST00000486340TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
5CDS-intronENST00000258796ENST00000486340TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
5CDS-intronENST00000258796ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
5CDS-intronENST00000407643ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
5CDS-intronENST00000407643ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
5CDS-intronENST00000407643ENST00000486340TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
5CDS-intronENST00000407643ENST00000486340TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
5CDS-intronENST00000407643ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
Frame-shiftENST00000258796ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
Frame-shiftENST00000258796ENST00000265854TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
Frame-shiftENST00000258796ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
Frame-shiftENST00000258796ENST00000399654TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
Frame-shiftENST00000258796ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
Frame-shiftENST00000258796ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
Frame-shiftENST00000258796ENST00000402746TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
Frame-shiftENST00000258796ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
Frame-shiftENST00000258796ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
Frame-shiftENST00000258796ENST00000406869TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
Frame-shiftENST00000258796ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
Frame-shiftENST00000407643ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
Frame-shiftENST00000407643ENST00000265854TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
Frame-shiftENST00000407643ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
Frame-shiftENST00000407643ENST00000399654TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
Frame-shiftENST00000407643ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
Frame-shiftENST00000407643ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
Frame-shiftENST00000407643ENST00000402746TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
Frame-shiftENST00000407643ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
Frame-shiftENST00000407643ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
Frame-shiftENST00000407643ENST00000406869TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
Frame-shiftENST00000407643ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
In-frameENST00000258796ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
In-frameENST00000258796ENST00000265854TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
In-frameENST00000258796ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
In-frameENST00000258796ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
In-frameENST00000258796ENST00000399654TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
In-frameENST00000258796ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
In-frameENST00000258796ENST00000402746TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
In-frameENST00000258796ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
In-frameENST00000258796ENST00000406869TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
In-frameENST00000407643ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
In-frameENST00000407643ENST00000265854TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
In-frameENST00000407643ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
In-frameENST00000407643ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
In-frameENST00000407643ENST00000399654TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
In-frameENST00000407643ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
In-frameENST00000407643ENST00000402746TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
In-frameENST00000407643ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
In-frameENST00000407643ENST00000406869TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-3CDSENST00000403167ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
intron-3CDSENST00000403167ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
intron-3CDSENST00000403167ENST00000265854TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
intron-3CDSENST00000403167ENST00000265854TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-3CDSENST00000403167ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
intron-3CDSENST00000403167ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
intron-3CDSENST00000403167ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
intron-3CDSENST00000403167ENST00000399654TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
intron-3CDSENST00000403167ENST00000399654TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-3CDSENST00000403167ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
intron-3CDSENST00000403167ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
intron-3CDSENST00000403167ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
intron-3CDSENST00000403167ENST00000402746TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
intron-3CDSENST00000403167ENST00000402746TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-3CDSENST00000403167ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
intron-3CDSENST00000403167ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
intron-3CDSENST00000403167ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
intron-3CDSENST00000403167ENST00000406869TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
intron-3CDSENST00000403167ENST00000406869TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-3CDSENST00000403167ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
intron-3CDSENST00000477439ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
intron-3CDSENST00000477439ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
intron-3CDSENST00000477439ENST00000265854TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
intron-3CDSENST00000477439ENST00000265854TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-3CDSENST00000477439ENST00000265854TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
intron-3CDSENST00000477439ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
intron-3CDSENST00000477439ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
intron-3CDSENST00000477439ENST00000399654TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
intron-3CDSENST00000477439ENST00000399654TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-3CDSENST00000477439ENST00000399654TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
intron-3CDSENST00000477439ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
intron-3CDSENST00000477439ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
intron-3CDSENST00000477439ENST00000402746TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
intron-3CDSENST00000477439ENST00000402746TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-3CDSENST00000477439ENST00000402746TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
intron-3CDSENST00000477439ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
intron-3CDSENST00000477439ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
intron-3CDSENST00000477439ENST00000406869TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
intron-3CDSENST00000477439ENST00000406869TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-3CDSENST00000477439ENST00000406869TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
intron-intronENST00000403167ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
intron-intronENST00000403167ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
intron-intronENST00000403167ENST00000486340TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
intron-intronENST00000403167ENST00000486340TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-intronENST00000403167ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

1938026

-
intron-intronENST00000477439ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

2020176

-
intron-intronENST00000477439ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

1855864

-
intron-intronENST00000477439ENST00000486340TTYH3chr7

2686656

+MAD1L1chr7

1976533

-
intron-intronENST00000477439ENST00000486340TTYH3chr7

2686887

+MAD1L1chr7

1976533

-
intron-intronENST00000477439ENST00000486340TTYH3chr7

2671912

+MAD1L1chr7

1938026

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258796TTYH3chr72671912+ENST00000399654MAD1L1chr71855864-763328719318133
ENST00000407643TTYH3chr72671912+ENST00000399654MAD1L1chr71855864-558123514113133
ENST00000258796TTYH3chr72671912+ENST00000402746MAD1L1chr72020176-13453289391313
ENST00000258796TTYH3chr72671912+ENST00000399654MAD1L1chr72020176-13453289391313
ENST00000258796TTYH3chr72671912+ENST00000406869MAD1L1chr72020176-13453289391313
ENST00000258796TTYH3chr72671912+ENST00000265854MAD1L1chr72020176-13283289391313
ENST00000407643TTYH3chr72671912+ENST00000402746MAD1L1chr72020176-11401230863287
ENST00000407643TTYH3chr72671912+ENST00000399654MAD1L1chr72020176-11401230863287
ENST00000407643TTYH3chr72671912+ENST00000406869MAD1L1chr72020176-11401230863287
ENST00000407643TTYH3chr72671912+ENST00000265854MAD1L1chr72020176-11231230863287
ENST00000258796TTYH3chr72686887+ENST00000402746MAD1L1chr71976533-144761010411347
ENST00000258796TTYH3chr72686887+ENST00000399654MAD1L1chr71976533-144761010411347
ENST00000258796TTYH3chr72686887+ENST00000406869MAD1L1chr71976533-144761010411347
ENST00000258796TTYH3chr72686887+ENST00000265854MAD1L1chr71976533-143061010411347
ENST00000407643TTYH3chr72686887+ENST00000402746MAD1L1chr71976533-12424050965321
ENST00000407643TTYH3chr72686887+ENST00000399654MAD1L1chr71976533-12424050965321
ENST00000407643TTYH3chr72686887+ENST00000406869MAD1L1chr71976533-12424050965321
ENST00000407643TTYH3chr72686887+ENST00000265854MAD1L1chr71976533-12254050965321

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258796ENST00000399654TTYH3chr72671912+MAD1L1chr71855864-0.143975750.85602427
ENST00000407643ENST00000399654TTYH3chr72671912+MAD1L1chr71855864-0.113021260.8869787
ENST00000258796ENST00000402746TTYH3chr72671912+MAD1L1chr72020176-0.004229270.99577075
ENST00000258796ENST00000399654TTYH3chr72671912+MAD1L1chr72020176-0.004229270.99577075
ENST00000258796ENST00000406869TTYH3chr72671912+MAD1L1chr72020176-0.004229270.99577075
ENST00000258796ENST00000265854TTYH3chr72671912+MAD1L1chr72020176-0.0039037420.9960963
ENST00000407643ENST00000402746TTYH3chr72671912+MAD1L1chr72020176-0.005456110.9945439
ENST00000407643ENST00000399654TTYH3chr72671912+MAD1L1chr72020176-0.005456110.9945439
ENST00000407643ENST00000406869TTYH3chr72671912+MAD1L1chr72020176-0.005456110.9945439
ENST00000407643ENST00000265854TTYH3chr72671912+MAD1L1chr72020176-0.0052144040.9947856
ENST00000258796ENST00000402746TTYH3chr72686887+MAD1L1chr71976533-0.0203785360.9796214
ENST00000258796ENST00000399654TTYH3chr72686887+MAD1L1chr71976533-0.0203785360.9796214
ENST00000258796ENST00000406869TTYH3chr72686887+MAD1L1chr71976533-0.0203785360.9796214
ENST00000258796ENST00000265854TTYH3chr72686887+MAD1L1chr71976533-0.0192053430.9807946
ENST00000407643ENST00000402746TTYH3chr72686887+MAD1L1chr71976533-0.0236659220.9763341
ENST00000407643ENST00000399654TTYH3chr72686887+MAD1L1chr71976533-0.0236659220.9763341
ENST00000407643ENST00000406869TTYH3chr72686887+MAD1L1chr71976533-0.0236659220.9763341
ENST00000407643ENST00000265854TTYH3chr72686887+MAD1L1chr71976533-0.0219241720.9780758

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Fusion Genomic Features for TTYH3-MAD1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTYH3-MAD1L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:2671912/chr7:1855864)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAD1L1

Q9Y6D9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+1141_4241524.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+1131_4241492.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+1141_4241524.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+1131_4241492.0Topological domainExtracellular
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+3141_42135524.0Topological domainExtracellular
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+31464_86135524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+3131_42135492.0Topological domainExtracellular
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+31364_86135492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+31443_63135524.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+31487_107135524.0TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+31343_63135492.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+31387_107135492.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+114108_21141524.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+114233_23641524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+114258_38641524.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+114408_52341524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+11464_8641524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+110108_2110353.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+1101_420353.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+110233_2360353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+110258_3860353.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+110408_5230353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+11064_860353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+113108_21141492.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+113233_23641492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+113258_38641492.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+113408_52341492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+11364_8641492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+114108_21141524.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+114233_23641524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+114258_38641524.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+114408_52341524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+11464_8641524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+110108_2110353.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+1101_420353.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+110233_2360353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+110258_3860353.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+110408_5230353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+11064_860353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+113108_21141492.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+113233_23641492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+113258_38641492.0Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+113408_52341492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+11364_8641492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+314108_211135524.0Topological domainExtracellular
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+314233_236135524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+314258_386135524.0Topological domainExtracellular
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+314408_523135524.0Topological domainCytoplasmic
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+110108_2110353.0Topological domainExtracellular
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+1101_420353.0Topological domainExtracellular
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+110233_2360353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+110258_3860353.0Topological domainExtracellular
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+110408_5230353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+11064_860353.0Topological domainCytoplasmic
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+313108_211135492.0Topological domainExtracellular
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+313233_236135492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+313258_386135492.0Topological domainExtracellular
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+313408_523135492.0Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+114212_23241524.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+114237_25741524.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+114387_40741524.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+11443_6341524.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:1855864ENST00000258796+11487_10741524.0TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+110212_2320353.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+110237_2570353.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+110387_4070353.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+11043_630353.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:1855864ENST00000403167+11087_1070353.0TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+113212_23241492.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+113237_25741492.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+113387_40741492.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+11343_6341492.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:1855864ENST00000407643+11387_10741492.0TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+114212_23241524.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+114237_25741524.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+114387_40741524.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+11443_6341524.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:2020176ENST00000258796+11487_10741524.0TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+110212_2320353.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+110237_2570353.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+110387_4070353.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+11043_630353.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:2020176ENST00000403167+11087_1070353.0TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+113212_23241492.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+113237_25741492.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+113387_40741492.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+11343_6341492.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:2020176ENST00000407643+11387_10741492.0TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+314212_232135524.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+314237_257135524.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2686887chr7:1976533ENST00000258796+314387_407135524.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+110212_2320353.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+110237_2570353.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+110387_4070353.0TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+11043_630353.0TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2686887chr7:1976533ENST00000403167+11087_1070353.0TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+313212_232135492.0TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+313237_257135492.0TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2686887chr7:1976533ENST00000407643+313387_407135492.0TransmembraneHelical%3B Name%3D5
TgeneMAD1L1chr7:2671912chr7:1855864ENST00000265854161846_632666719.0Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr7:2671912chr7:1855864ENST00000399654171946_632666719.0Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr7:2671912chr7:1855864ENST00000406869171946_632666719.0Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr7:2671912chr7:2020176ENST00000265854121846_632472719.0Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr7:2671912chr7:2020176ENST00000399654131946_632472719.0Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr7:2671912chr7:2020176ENST00000406869131946_632472719.0Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr7:2686887chr7:1976533ENST00000265854141846_632532719.0Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr7:2686887chr7:1976533ENST00000399654151946_632532719.0Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr7:2686887chr7:1976533ENST00000406869151946_632532719.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for TTYH3-MAD1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95260_95260_1_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000258796_MAD1L1_chr7_1855864_ENST00000399654_length(transcript)=763nt_BP=328nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCT
ACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCT
CACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGG
TCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCT
ACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAG

>95260_95260_1_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000258796_MAD1L1_chr7_1855864_ENST00000399654_length(amino acids)=133AA_BP=1
MVADAHTPGSGTHGVCTWRGCWPPQQEARRRSQRVCQSCCCPVGLERQDVHPACGWRGRGPAGQAKQSGSGYAPEPAGYATVWRLKSSRV

--------------------------------------------------------------
>95260_95260_2_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000258796_MAD1L1_chr7_2020176_ENST00000265854_length(transcript)=1328nt_BP=328nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCA
GTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAG
TCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCT
GCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGG
GCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGA
GCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTG
CTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCT
CATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCA
CCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTC
GGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAG
CCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGAC

>95260_95260_2_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000258796_MAD1L1_chr7_2020176_ENST00000265854_length(amino acids)=313AA_BP=1
MHLGTRGAGGLEDEAVAWVLGVQRGQPVLVLRGDVDLVAGERVAGLAELLDLGLENLLEPLVLQLGTLHLLLQLCHLLGRWQTRGGSLKV
GWDGASSLHGAQEPAQSLALRLQLAVVLAQALPGHTGGVQAHVQHFGPALVIVTLQSSPLQLCLQHPLFLLQPTPLAFQLLDLQPERVRL
LPGEQEALFGRAGLRLQHLQLHLQLLVVGVLGPELAASGLPAQVEVGQPVQEAHPPGRRVADPGHGGARPPPDARGLRGAPLLARGAGFR

--------------------------------------------------------------
>95260_95260_3_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000258796_MAD1L1_chr7_2020176_ENST00000399654_length(transcript)=1345nt_BP=328nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCA
GTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAG
TCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCT
GCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGG
GCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGA
GCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTG
CTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCT
CATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCA
CCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTC
GGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAG
CCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGAC

>95260_95260_3_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000258796_MAD1L1_chr7_2020176_ENST00000399654_length(amino acids)=313AA_BP=1
MHLGTRGAGGLEDEAVAWVLGVQRGQPVLVLRGDVDLVAGERVAGLAELLDLGLENLLEPLVLQLGTLHLLLQLCHLLGRWQTRGGSLKV
GWDGASSLHGAQEPAQSLALRLQLAVVLAQALPGHTGGVQAHVQHFGPALVIVTLQSSPLQLCLQHPLFLLQPTPLAFQLLDLQPERVRL
LPGEQEALFGRAGLRLQHLQLHLQLLVVGVLGPELAASGLPAQVEVGQPVQEAHPPGRRVADPGHGGARPPPDARGLRGAPLLARGAGFR

--------------------------------------------------------------
>95260_95260_4_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000258796_MAD1L1_chr7_2020176_ENST00000402746_length(transcript)=1345nt_BP=328nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCA
GTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAG
TCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCT
GCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGG
GCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGA
GCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTG
CTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCT
CATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCA
CCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTC
GGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAG
CCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGAC

>95260_95260_4_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000258796_MAD1L1_chr7_2020176_ENST00000402746_length(amino acids)=313AA_BP=1
MHLGTRGAGGLEDEAVAWVLGVQRGQPVLVLRGDVDLVAGERVAGLAELLDLGLENLLEPLVLQLGTLHLLLQLCHLLGRWQTRGGSLKV
GWDGASSLHGAQEPAQSLALRLQLAVVLAQALPGHTGGVQAHVQHFGPALVIVTLQSSPLQLCLQHPLFLLQPTPLAFQLLDLQPERVRL
LPGEQEALFGRAGLRLQHLQLHLQLLVVGVLGPELAASGLPAQVEVGQPVQEAHPPGRRVADPGHGGARPPPDARGLRGAPLLARGAGFR

--------------------------------------------------------------
>95260_95260_5_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000258796_MAD1L1_chr7_2020176_ENST00000406869_length(transcript)=1345nt_BP=328nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCA
GTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAG
TCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCT
GCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGG
GCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGA
GCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTG
CTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCT
CATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCA
CCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTC
GGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAG
CCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGAC

>95260_95260_5_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000258796_MAD1L1_chr7_2020176_ENST00000406869_length(amino acids)=313AA_BP=1
MHLGTRGAGGLEDEAVAWVLGVQRGQPVLVLRGDVDLVAGERVAGLAELLDLGLENLLEPLVLQLGTLHLLLQLCHLLGRWQTRGGSLKV
GWDGASSLHGAQEPAQSLALRLQLAVVLAQALPGHTGGVQAHVQHFGPALVIVTLQSSPLQLCLQHPLFLLQPTPLAFQLLDLQPERVRL
LPGEQEALFGRAGLRLQHLQLHLQLLVVGVLGPELAASGLPAQVEVGQPVQEAHPPGRRVADPGHGGARPPPDARGLRGAPLLARGAGFR

--------------------------------------------------------------
>95260_95260_6_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000407643_MAD1L1_chr7_1855864_ENST00000399654_length(transcript)=558nt_BP=123nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACC
GTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAG
ACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCT
GGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGC
CAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTCACCTTGTGAAATA

>95260_95260_6_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000407643_MAD1L1_chr7_1855864_ENST00000399654_length(amino acids)=133AA_BP=1
MVADAHTPGSGTHGVCTWRGCWPPQQEARRRSQRVCQSCCCPVGLERQDVHPACGWRGRGPAGQAKQSGSGYAPEPAGYATVWRLKSSRV

--------------------------------------------------------------
>95260_95260_7_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000407643_MAD1L1_chr7_2020176_ENST00000265854_length(transcript)=1123nt_BP=123nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTC
CTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATG
CTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGT
GTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGA
GGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCC
GAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATC
GACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCG
GGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCT
GCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGC
TTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGA
CAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTG

>95260_95260_7_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000407643_MAD1L1_chr7_2020176_ENST00000265854_length(amino acids)=287AA_BP=41
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRM
LEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESA
ELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIP

--------------------------------------------------------------
>95260_95260_8_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000407643_MAD1L1_chr7_2020176_ENST00000399654_length(transcript)=1140nt_BP=123nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTC
CTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATG
CTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGT
GTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGA
GGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCC
GAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATC
GACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCG
GGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCT
GCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGC
TTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGA
CAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTG

>95260_95260_8_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000407643_MAD1L1_chr7_2020176_ENST00000399654_length(amino acids)=287AA_BP=41
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRM
LEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESA
ELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIP

--------------------------------------------------------------
>95260_95260_9_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000407643_MAD1L1_chr7_2020176_ENST00000402746_length(transcript)=1140nt_BP=123nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTC
CTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATG
CTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGT
GTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGA
GGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCC
GAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATC
GACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCG
GGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCT
GCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGC
TTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGA
CAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTG

>95260_95260_9_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000407643_MAD1L1_chr7_2020176_ENST00000402746_length(amino acids)=287AA_BP=41
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRM
LEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESA
ELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIP

--------------------------------------------------------------
>95260_95260_10_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000407643_MAD1L1_chr7_2020176_ENST00000406869_length(transcript)=1140nt_BP=123nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTC
CTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATG
CTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGT
GTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGA
GGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCC
GAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATC
GACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCG
GGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCT
GCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGC
TTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGA
CAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTG

>95260_95260_10_TTYH3-MAD1L1_TTYH3_chr7_2671912_ENST00000407643_MAD1L1_chr7_2020176_ENST00000406869_length(amino acids)=287AA_BP=41
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRM
LEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESA
ELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIP

--------------------------------------------------------------
>95260_95260_11_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000258796_MAD1L1_chr7_1976533_ENST00000265854_length(transcript)=1430nt_BP=610nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGGCCCTGCTGCTCCTGGGGGCCGCCGCCCTGGC
CTGCCTCGCCCTGGACCTCCTCTTCCTGCTCTTCTACTCCTTCTGGCTGTGCTGCCGGCGGCGCAAGAGCGAGGAGCACCTGGACGCCGA
CTGCTGCTGCACGGCCTGGTGTGTCATCATCGCCACGCTGGTGTGCAGCGCCGGCATCGCAGTGGGATTCTACGGCAACGGGGAGACCAG
TGATGGCATCCATAGGGCCACCTACTCGCTCCGCCACGCCAACCGCACGGTGGCCGGGGTCCAGGACCGCGGTGACTATGACCAGAGCAG
GACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGA
GCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAA
GGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTT
CCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCC
AGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCT
CATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTA
GCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTC
CTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCT

>95260_95260_11_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000258796_MAD1L1_chr7_1976533_ENST00000265854_length(amino acids)=347AA_BP=1
MHLGTRGAGGLEDEAVAWVLGVQRGQPVLVLRGDVDLVAGERVAGLAELLDLGLENLLEPLVLQLGTLHLLLQLCHLLGRWQTRGGSLKV
GWDGASSLHGAQEPAQSLALRLQLAVVLAQALPGHTGGVQAHVQHFGPALVIVTAVLDPGHRAVGVAERVGGPMDAITGLPVAVESHCDA
GAAHQRGDDDTPGRAAAVGVQVLLALAPPAAQPEGVEEQEEEVQGEAGQGGGPQEQQGLLVVGVLGPELAASGLPAQVEVGQPVQEAHPP

--------------------------------------------------------------
>95260_95260_12_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000258796_MAD1L1_chr7_1976533_ENST00000399654_length(transcript)=1447nt_BP=610nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGGCCCTGCTGCTCCTGGGGGCCGCCGCCCTGGC
CTGCCTCGCCCTGGACCTCCTCTTCCTGCTCTTCTACTCCTTCTGGCTGTGCTGCCGGCGGCGCAAGAGCGAGGAGCACCTGGACGCCGA
CTGCTGCTGCACGGCCTGGTGTGTCATCATCGCCACGCTGGTGTGCAGCGCCGGCATCGCAGTGGGATTCTACGGCAACGGGGAGACCAG
TGATGGCATCCATAGGGCCACCTACTCGCTCCGCCACGCCAACCGCACGGTGGCCGGGGTCCAGGACCGCGGTGACTATGACCAGAGCAG
GACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGA
GCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAA
GGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTT
CCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCC
AGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCT
CATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTA
GCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTC
CTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCT
CCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTCACCTTGTGAAATAAAATCTTCTCC

>95260_95260_12_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000258796_MAD1L1_chr7_1976533_ENST00000399654_length(amino acids)=347AA_BP=1
MHLGTRGAGGLEDEAVAWVLGVQRGQPVLVLRGDVDLVAGERVAGLAELLDLGLENLLEPLVLQLGTLHLLLQLCHLLGRWQTRGGSLKV
GWDGASSLHGAQEPAQSLALRLQLAVVLAQALPGHTGGVQAHVQHFGPALVIVTAVLDPGHRAVGVAERVGGPMDAITGLPVAVESHCDA
GAAHQRGDDDTPGRAAAVGVQVLLALAPPAAQPEGVEEQEEEVQGEAGQGGGPQEQQGLLVVGVLGPELAASGLPAQVEVGQPVQEAHPP

--------------------------------------------------------------
>95260_95260_13_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000258796_MAD1L1_chr7_1976533_ENST00000402746_length(transcript)=1447nt_BP=610nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGGCCCTGCTGCTCCTGGGGGCCGCCGCCCTGGC
CTGCCTCGCCCTGGACCTCCTCTTCCTGCTCTTCTACTCCTTCTGGCTGTGCTGCCGGCGGCGCAAGAGCGAGGAGCACCTGGACGCCGA
CTGCTGCTGCACGGCCTGGTGTGTCATCATCGCCACGCTGGTGTGCAGCGCCGGCATCGCAGTGGGATTCTACGGCAACGGGGAGACCAG
TGATGGCATCCATAGGGCCACCTACTCGCTCCGCCACGCCAACCGCACGGTGGCCGGGGTCCAGGACCGCGGTGACTATGACCAGAGCAG
GACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGA
GCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAA
GGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTT
CCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCC
AGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCT
CATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTA
GCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTC
CTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCT
CCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTCACCTTGTGAAATAAAATCTTCTCC

>95260_95260_13_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000258796_MAD1L1_chr7_1976533_ENST00000402746_length(amino acids)=347AA_BP=1
MHLGTRGAGGLEDEAVAWVLGVQRGQPVLVLRGDVDLVAGERVAGLAELLDLGLENLLEPLVLQLGTLHLLLQLCHLLGRWQTRGGSLKV
GWDGASSLHGAQEPAQSLALRLQLAVVLAQALPGHTGGVQAHVQHFGPALVIVTAVLDPGHRAVGVAERVGGPMDAITGLPVAVESHCDA
GAAHQRGDDDTPGRAAAVGVQVLLALAPPAAQPEGVEEQEEEVQGEAGQGGGPQEQQGLLVVGVLGPELAASGLPAQVEVGQPVQEAHPP

--------------------------------------------------------------
>95260_95260_14_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000258796_MAD1L1_chr7_1976533_ENST00000406869_length(transcript)=1447nt_BP=610nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGGCCCTGCTGCTCCTGGGGGCCGCCGCCCTGGC
CTGCCTCGCCCTGGACCTCCTCTTCCTGCTCTTCTACTCCTTCTGGCTGTGCTGCCGGCGGCGCAAGAGCGAGGAGCACCTGGACGCCGA
CTGCTGCTGCACGGCCTGGTGTGTCATCATCGCCACGCTGGTGTGCAGCGCCGGCATCGCAGTGGGATTCTACGGCAACGGGGAGACCAG
TGATGGCATCCATAGGGCCACCTACTCGCTCCGCCACGCCAACCGCACGGTGGCCGGGGTCCAGGACCGCGGTGACTATGACCAGAGCAG
GACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGA
GCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAA
GGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTT
CCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCC
AGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCT
CATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTA
GCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTC
CTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCT
CCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTCACCTTGTGAAATAAAATCTTCTCC

>95260_95260_14_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000258796_MAD1L1_chr7_1976533_ENST00000406869_length(amino acids)=347AA_BP=1
MHLGTRGAGGLEDEAVAWVLGVQRGQPVLVLRGDVDLVAGERVAGLAELLDLGLENLLEPLVLQLGTLHLLLQLCHLLGRWQTRGGSLKV
GWDGASSLHGAQEPAQSLALRLQLAVVLAQALPGHTGGVQAHVQHFGPALVIVTAVLDPGHRAVGVAERVGGPMDAITGLPVAVESHCDA
GAAHQRGDDDTPGRAAAVGVQVLLALAPPAAQPEGVEEQEEEVQGEAGQGGGPQEQQGLLVVGVLGPELAASGLPAQVEVGQPVQEAHPP

--------------------------------------------------------------
>95260_95260_15_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000407643_MAD1L1_chr7_1976533_ENST00000265854_length(transcript)=1225nt_BP=405nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGCCCTGCTGCTCCTGGGGGCCGCCGCCCTGGCCTGCCTCGCCCTGGACCTCCTCTTC
CTGCTCTTCTACTCCTTCTGGCTGTGCTGCCGGCGGCGCAAGAGCGAGGAGCACCTGGACGCCGACTGCTGCTGCACGGCCTGGTGTGTC
ATCATCGCCACGCTGGTGTGCAGCGCCGGCATCGCAGTGGGATTCTACGGCAACGGGGAGACCAGTGATGGCATCCATAGGGCCACCTAC
TCGCTCCGCCACGCCAACCGCACGGTGGCCGGGGTCCAGGACCGCGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTG
AACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCC
ATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAG
GTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACC
GGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCC
ACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAG
GACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCG
GAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAG
CAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCG

>95260_95260_15_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000407643_MAD1L1_chr7_1976533_ENST00000265854_length(amino acids)=321AA_BP=135
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLFLLFYSFWLCCRRRKSEEHLDADCCCTAWCV
IIATLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRA
MERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKA

--------------------------------------------------------------
>95260_95260_16_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000407643_MAD1L1_chr7_1976533_ENST00000399654_length(transcript)=1242nt_BP=405nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGCCCTGCTGCTCCTGGGGGCCGCCGCCCTGGCCTGCCTCGCCCTGGACCTCCTCTTC
CTGCTCTTCTACTCCTTCTGGCTGTGCTGCCGGCGGCGCAAGAGCGAGGAGCACCTGGACGCCGACTGCTGCTGCACGGCCTGGTGTGTC
ATCATCGCCACGCTGGTGTGCAGCGCCGGCATCGCAGTGGGATTCTACGGCAACGGGGAGACCAGTGATGGCATCCATAGGGCCACCTAC
TCGCTCCGCCACGCCAACCGCACGGTGGCCGGGGTCCAGGACCGCGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTG
AACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCC
ATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAG
GTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACC
GGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCC
ACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAG
GACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCG
GAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAG
CAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCG

>95260_95260_16_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000407643_MAD1L1_chr7_1976533_ENST00000399654_length(amino acids)=321AA_BP=135
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLFLLFYSFWLCCRRRKSEEHLDADCCCTAWCV
IIATLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRA
MERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKA

--------------------------------------------------------------
>95260_95260_17_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000407643_MAD1L1_chr7_1976533_ENST00000402746_length(transcript)=1242nt_BP=405nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGCCCTGCTGCTCCTGGGGGCCGCCGCCCTGGCCTGCCTCGCCCTGGACCTCCTCTTC
CTGCTCTTCTACTCCTTCTGGCTGTGCTGCCGGCGGCGCAAGAGCGAGGAGCACCTGGACGCCGACTGCTGCTGCACGGCCTGGTGTGTC
ATCATCGCCACGCTGGTGTGCAGCGCCGGCATCGCAGTGGGATTCTACGGCAACGGGGAGACCAGTGATGGCATCCATAGGGCCACCTAC
TCGCTCCGCCACGCCAACCGCACGGTGGCCGGGGTCCAGGACCGCGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTG
AACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCC
ATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAG
GTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACC
GGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCC
ACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAG
GACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCG
GAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAG
CAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCG

>95260_95260_17_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000407643_MAD1L1_chr7_1976533_ENST00000402746_length(amino acids)=321AA_BP=135
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLFLLFYSFWLCCRRRKSEEHLDADCCCTAWCV
IIATLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRA
MERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKA

--------------------------------------------------------------
>95260_95260_18_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000407643_MAD1L1_chr7_1976533_ENST00000406869_length(transcript)=1242nt_BP=405nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGCCCTGCTGCTCCTGGGGGCCGCCGCCCTGGCCTGCCTCGCCCTGGACCTCCTCTTC
CTGCTCTTCTACTCCTTCTGGCTGTGCTGCCGGCGGCGCAAGAGCGAGGAGCACCTGGACGCCGACTGCTGCTGCACGGCCTGGTGTGTC
ATCATCGCCACGCTGGTGTGCAGCGCCGGCATCGCAGTGGGATTCTACGGCAACGGGGAGACCAGTGATGGCATCCATAGGGCCACCTAC
TCGCTCCGCCACGCCAACCGCACGGTGGCCGGGGTCCAGGACCGCGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTG
AACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCC
ATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAG
GTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACC
GGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCC
ACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAG
GACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCG
GAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAG
CAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCG

>95260_95260_18_TTYH3-MAD1L1_TTYH3_chr7_2686887_ENST00000407643_MAD1L1_chr7_1976533_ENST00000406869_length(amino acids)=321AA_BP=135
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLFLLFYSFWLCCRRRKSEEHLDADCCCTAWCV
IIATLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRA
MERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TTYH3-MAD1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTYH3-MAD1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTYH3-MAD1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource