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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TUBB6-INTS8 (FusionGDB2 ID:95348)

Fusion Gene Summary for TUBB6-INTS8

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBB6-INTS8
Fusion gene ID: 95348
HgeneTgene
Gene symbol

TUBB6

INTS8

Gene ID

84617

55656

Gene nametubulin beta 6 class Vintegrator complex subunit 8
SynonymsFPVEPD|HsT1601|TUBB-5C8orf52|INT8|NEDCHS
Cytomap

18p11.21

8q22.1

Type of geneprotein-codingprotein-coding
Descriptiontubulin beta-6 chainclass V beta-tubulintubulin beta MGC4083tubulin beta class Vtubulin, beta 6integrator complex subunit 8protein kaonashi-1
Modification date2020032020200313
UniProtAcc.

Q75QN2

Ensembl transtripts involved in fusion geneENST00000317702, ENST00000586653, 
ENST00000590967, ENST00000591208, 
ENST00000591909, ENST00000592683, 
ENST00000520845, ENST00000447247, 
ENST00000523731, 
Fusion gene scores* DoF score5 X 4 X 4=805 X 5 X 5=125
# samples 55
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUBB6 [Title/Abstract] AND INTS8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTUBB6(12311052)-INTS8(95885601), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINTS8

GO:0016180

snRNA processing

16239144


check buttonFusion gene breakpoints across TUBB6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across INTS8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1603TUBB6chr18

12311052

+INTS8chr8

95885601

+


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Fusion Gene ORF analysis for TUBB6-INTS8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000317702ENST00000520845TUBB6chr18

12311052

+INTS8chr8

95885601

+
5CDS-intronENST00000586653ENST00000520845TUBB6chr18

12311052

+INTS8chr8

95885601

+
5CDS-intronENST00000590967ENST00000520845TUBB6chr18

12311052

+INTS8chr8

95885601

+
5CDS-intronENST00000591208ENST00000520845TUBB6chr18

12311052

+INTS8chr8

95885601

+
5CDS-intronENST00000591909ENST00000520845TUBB6chr18

12311052

+INTS8chr8

95885601

+
5CDS-intronENST00000592683ENST00000520845TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000317702ENST00000447247TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000317702ENST00000523731TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000586653ENST00000447247TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000586653ENST00000523731TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000590967ENST00000447247TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000590967ENST00000523731TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000591208ENST00000447247TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000591208ENST00000523731TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000591909ENST00000447247TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000591909ENST00000523731TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000592683ENST00000447247TUBB6chr18

12311052

+INTS8chr8

95885601

+
In-frameENST00000592683ENST00000523731TUBB6chr18

12311052

+INTS8chr8

95885601

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317702TUBB6chr1812311052+ENST00000523731INTS8chr895885601+2478511234965243
ENST00000317702TUBB6chr1812311052+ENST00000447247INTS8chr895885601+1173511234914226
ENST00000591909TUBB6chr1812311052+ENST00000523731INTS8chr895885601+230333659790243
ENST00000591909TUBB6chr1812311052+ENST00000447247INTS8chr895885601+99833659739226
ENST00000586653TUBB6chr1812311052+ENST00000523731INTS8chr895885601+229632952783243
ENST00000586653TUBB6chr1812311052+ENST00000447247INTS8chr895885601+99132952732226
ENST00000592683TUBB6chr1812311052+ENST00000523731INTS8chr895885601+229032346777243
ENST00000592683TUBB6chr1812311052+ENST00000447247INTS8chr895885601+98532346726226
ENST00000590967TUBB6chr1812311052+ENST00000523731INTS8chr895885601+228431740771243
ENST00000590967TUBB6chr1812311052+ENST00000447247INTS8chr895885601+97931740720226
ENST00000591208TUBB6chr1812311052+ENST00000523731INTS8chr895885601+227530831762243
ENST00000591208TUBB6chr1812311052+ENST00000447247INTS8chr895885601+97030831711226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317702ENST00000523731TUBB6chr1812311052+INTS8chr895885601+0.0003509240.99964905
ENST00000317702ENST00000447247TUBB6chr1812311052+INTS8chr895885601+0.0005783220.9994217
ENST00000591909ENST00000523731TUBB6chr1812311052+INTS8chr895885601+0.0003584550.99964154
ENST00000591909ENST00000447247TUBB6chr1812311052+INTS8chr895885601+0.000563610.9994363
ENST00000586653ENST00000523731TUBB6chr1812311052+INTS8chr895885601+0.0003105050.99968946
ENST00000586653ENST00000447247TUBB6chr1812311052+INTS8chr895885601+0.0005081070.99949193
ENST00000592683ENST00000523731TUBB6chr1812311052+INTS8chr895885601+0.0003388760.9996611
ENST00000592683ENST00000447247TUBB6chr1812311052+INTS8chr895885601+0.0005696490.99943036
ENST00000590967ENST00000523731TUBB6chr1812311052+INTS8chr895885601+0.0003833640.9996166
ENST00000590967ENST00000447247TUBB6chr1812311052+INTS8chr895885601+0.0005285690.9994715
ENST00000591208ENST00000523731TUBB6chr1812311052+INTS8chr895885601+0.0003311520.99966884
ENST00000591208ENST00000447247TUBB6chr1812311052+INTS8chr895885601+0.0004999910.99950004

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Fusion Genomic Features for TUBB6-INTS8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TUBB6chr1812311052+INTS8chr895885601+3.96E-050.9999604
TUBB6chr1812311052+INTS8chr895885601+3.96E-050.9999604

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TUBB6-INTS8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:12311052/chr8:95885601)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.INTS8

Q75QN2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. {ECO:0000269|PubMed:28542170}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUBB6chr18:12311052chr8:95885601ENST00000317702+34140_14692447.0Nucleotide bindingGTP
TgeneINTS8chr18:12311052chr8:95885601ENST000004472472026250_288844979.0RepeatNote=TPR 1
TgeneINTS8chr18:12311052chr8:95885601ENST000004472472026320_356844979.0RepeatNote=TPR 2
TgeneINTS8chr18:12311052chr8:95885601ENST000004472472026570_603844979.0RepeatNote=TPR 3
TgeneINTS8chr18:12311052chr8:95885601ENST000004472472026833_866844979.0RepeatNote=TPR 4
TgeneINTS8chr18:12311052chr8:95885601ENST000005237312027250_288844996.0RepeatNote=TPR 1
TgeneINTS8chr18:12311052chr8:95885601ENST000005237312027320_356844996.0RepeatNote=TPR 2
TgeneINTS8chr18:12311052chr8:95885601ENST000005237312027570_603844996.0RepeatNote=TPR 3
TgeneINTS8chr18:12311052chr8:95885601ENST000005237312027833_866844996.0RepeatNote=TPR 4


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Fusion Gene Sequence for TUBB6-INTS8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95348_95348_1_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000317702_INTS8_chr8_95885601_ENST00000447247_length(transcript)=1173nt_BP=511nt
TTTTCCGCCCGGCTCCCGGCAAGGGTCCCCCGACTGGCGCCCGCGCGTCCTCCCTCGGCTGCTGCAGGCCGGGCCGCGGCGTCGAGCGGG
GGCGGCGGGGCGGGGCCCGCAGCCATTGGCGAGCGGCGGGGCGGGGGCGGGGGCGCGGAGGGTCGGCCCCGGGACGCGCGCAGCCGGCCC
GCAGTTGCCGCTGTCGTCCGCAGAGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGC
GGGAACCAGATCGGCACCAAGTTTTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGGCGCTG
CAGCTGGAGAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACC
ATGGACAGCGTGCGGTCTGGGCCTTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTCTTCAC
TATTACCTCCAGGCAGGAGCTGTGTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTGGCCATTTTATGT
CAGTTCCTCAGAGAAATTGACTACAAAACAGCGTTTAAATCTCTGCAAGAACAAAACAGTCATGATGCTATGGACTCCTACTACGACTAC
ATATGGGATGTTACCATTTTGGAATACTTGACTTATCTTCATCATAAAAGAGGAGAAACAGATAAAAGACAAATTGCAATCAAAGCCATC
GGCCAGACAGAGTTGAATGCAAGCAATCCAGAAGAAGTGTTACAGCTGGCAGCGCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAATGGCA
AAACTTTACTTTTAAGCAGTTAAATTTTTTTAACTTTTATTTTTTAAACAATGGGCTAAAAATAAACAGTATTAAAAGGTTAAGTTTATA
TAATACATATGTACACAATTAGTGGTGTTTTCTTTTCAGACAAAATACTGAAACAAATATTAGTTTAAAAACAAACTATACAGAAGACTT
CATACCGTAACAATAAATGTATAGTTTCTTCAAAGGGAGAAGAGATTCACATATCTGATAACAAAATAAACTAGCAATCTAGTTTTCTAA

>95348_95348_1_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000317702_INTS8_chr8_95885601_ENST00000447247_length(amino acids)=226AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRG

--------------------------------------------------------------
>95348_95348_2_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000317702_INTS8_chr8_95885601_ENST00000523731_length(transcript)=2478nt_BP=511nt
TTTTCCGCCCGGCTCCCGGCAAGGGTCCCCCGACTGGCGCCCGCGCGTCCTCCCTCGGCTGCTGCAGGCCGGGCCGCGGCGTCGAGCGGG
GGCGGCGGGGCGGGGCCCGCAGCCATTGGCGAGCGGCGGGGCGGGGGCGGGGGCGCGGAGGGTCGGCCCCGGGACGCGCGCAGCCGGCCC
GCAGTTGCCGCTGTCGTCCGCAGAGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGC
GGGAACCAGATCGGCACCAAGTTTTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGGCGCTG
CAGCTGGAGAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACC
ATGGACAGCGTGCGGTCTGGGCCTTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTCTTCAC
TATTACCTCCAGGCAGGAGCTGTGTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTAATAAAACGAATG
ATAAAATGTTGTTCTTTGCTGAATTGCCACACACAGGTGGCCATTTTATGTCAGTTCCTCAGAGAAATTGACTACAAAACAGCGTTTAAA
TCTCTGCAAGAACAAAACAGTCATGATGCTATGGACTCCTACTACGACTACATATGGGATGTTACCATTTTGGAATACTTGACTTATCTT
CATCATAAAAGAGGAGAAACAGATAAAAGACAAATTGCAATCAAAGCCATCGGCCAGACAGAGTTGAATGCAAGCAATCCAGAAGAAGTG
TTACAGCTGGCAGCGCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAATGGCAAAACTTTACTTTTAAGCAGTTAAATTTTTTTAACTTTTA
TTTTTTAAACAATGGGCTAAAAATAAACAGTATTAAAAGGTTAAGTTTATATAATACATATGTACACAATTAGTGGTGTTTTCTTTTCAG
ACAAAATACTGAAACAAATATTAGTTTAAAAACAAACTATACAGAAGACTTCATACCGTAACAATAAATGTATAGTTTCTTCAAAGGGAG
AAGAGATTCACATATCTGATAACAAAATAAACTAGCAATCTAGTTTTCTAATCTACTTTATGAGGCTGGATTTTTTTTTTAGAAAAGCTA
ATTTAAAATATTTAGAAATAGCTAGCCTATGTACAGCAAGTTTTCATGTCTTTTTTTAATAAATAGATTTCTAGGAGTCAGTATATATTT
AATACTCTTCTTCCTTAAGAAAATAGAAGTTTAGGTCAAGTGTTAAGCTTTATCACTTTGACACTGTCCTTATCTCACAATGGAGGAATT
TAGAAAGGACCTTAACAGTTTCACAAACATAAATAAAGCCTTAGTCACACTAAATTAAAAAAAAAAATTCCTTAGGGATATCTTAGAGTA
GTAAAGTGACTTCCTCATATAAATAGTTTGAAAGGGTACTTAAGTTTTTCACCCAAATTGTGATATACAAAAAGGTTATTACCAAGCAAC
CTACATGTCAAGAAAGCCCCAGTTAGGAAGGAGCCACAGCATTTATCTTGTTTATAATTTCTTTGGTACTCCCACTGTTTAGAGCACAGG
TTGAACACCATGTTCATCTAAGCCTTATTAGTTAAAAAATGTGTTATGGCAAGGCAAATAAACTAGTTTAAAAAACATTAAATTTCACCA
TTTGTAGAAATTCAAGTTTTATAATAGCTTGCTATAGCAGCTATAGATAAATTAGTCACCTTATTACAAAACTAAACCTTTGTAAACAAG
TTTAAATTTAATTTTCAAGAACCAAATTGCACTAGTCAAGAGTGTAGGAATTTTGAGAATCTAACAACTAGATTCAAAGTACTGTATCAC
TTAGTATACCCTTTAAGGTAGCACTTATCCAGTCCAAAACTCCAGTGACAAAATTCCTAGTTTATCAAGATAAACACAGTAACACTGGAT
TAAAGGAAAAACATTGCTATGGTATAGACTGTGGTTGGCTTCTATCCAGTAACCTTGGGAATGAAGACATCTTTGTAAACAAGTCCTGCT
GTTTCTTTAACAGCTAACATAGGAAATAATTAAATGTATTCTTTAGTGCCAATTGTAAGTTTTAAAATCAGAATGGCAGTGTAACTTGTG
AATTGGCTAGGGCAATCAATCACAGCACTACTTTCTGTAAAACTTTAGTAGTTCAGTGATACCAGTTCTACCCAATCTTGGTGAATTCCA
ACTTGTTTGCTTAGTTATCTTCTTTAGTGTTTTCCTGGTGGTTTTTCAGTGCTCTTCGGTGGTGTCATAATGCCTCCATTGCACACTGGT

>95348_95348_2_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000317702_INTS8_chr8_95885601_ENST00000523731_length(amino acids)=243AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYI

--------------------------------------------------------------
>95348_95348_3_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000586653_INTS8_chr8_95885601_ENST00000447247_length(transcript)=991nt_BP=329nt
AGTTGCCGCTGTCGTCCGCAGAGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGG
GAACCAGATCGGCACCAAGTTTTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGGCGCTGCA
GCTGGAGAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCAT
GGACAGCGTGCGGTCTGGGCCTTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTCTTCACTA
TTACCTCCAGGCAGGAGCTGTGTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTGGCCATTTTATGTCA
GTTCCTCAGAGAAATTGACTACAAAACAGCGTTTAAATCTCTGCAAGAACAAAACAGTCATGATGCTATGGACTCCTACTACGACTACAT
ATGGGATGTTACCATTTTGGAATACTTGACTTATCTTCATCATAAAAGAGGAGAAACAGATAAAAGACAAATTGCAATCAAAGCCATCGG
CCAGACAGAGTTGAATGCAAGCAATCCAGAAGAAGTGTTACAGCTGGCAGCGCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAATGGCAAA
ACTTTACTTTTAAGCAGTTAAATTTTTTTAACTTTTATTTTTTAAACAATGGGCTAAAAATAAACAGTATTAAAAGGTTAAGTTTATATA
ATACATATGTACACAATTAGTGGTGTTTTCTTTTCAGACAAAATACTGAAACAAATATTAGTTTAAAAACAAACTATACAGAAGACTTCA
TACCGTAACAATAAATGTATAGTTTCTTCAAAGGGAGAAGAGATTCACATATCTGATAACAAAATAAACTAGCAATCTAGTTTTCTAATC

>95348_95348_3_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000586653_INTS8_chr8_95885601_ENST00000447247_length(amino acids)=226AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRG

--------------------------------------------------------------
>95348_95348_4_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000586653_INTS8_chr8_95885601_ENST00000523731_length(transcript)=2296nt_BP=329nt
AGTTGCCGCTGTCGTCCGCAGAGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGG
GAACCAGATCGGCACCAAGTTTTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGGCGCTGCA
GCTGGAGAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCAT
GGACAGCGTGCGGTCTGGGCCTTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTCTTCACTA
TTACCTCCAGGCAGGAGCTGTGTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTAATAAAACGAATGAT
AAAATGTTGTTCTTTGCTGAATTGCCACACACAGGTGGCCATTTTATGTCAGTTCCTCAGAGAAATTGACTACAAAACAGCGTTTAAATC
TCTGCAAGAACAAAACAGTCATGATGCTATGGACTCCTACTACGACTACATATGGGATGTTACCATTTTGGAATACTTGACTTATCTTCA
TCATAAAAGAGGAGAAACAGATAAAAGACAAATTGCAATCAAAGCCATCGGCCAGACAGAGTTGAATGCAAGCAATCCAGAAGAAGTGTT
ACAGCTGGCAGCGCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAATGGCAAAACTTTACTTTTAAGCAGTTAAATTTTTTTAACTTTTATT
TTTTAAACAATGGGCTAAAAATAAACAGTATTAAAAGGTTAAGTTTATATAATACATATGTACACAATTAGTGGTGTTTTCTTTTCAGAC
AAAATACTGAAACAAATATTAGTTTAAAAACAAACTATACAGAAGACTTCATACCGTAACAATAAATGTATAGTTTCTTCAAAGGGAGAA
GAGATTCACATATCTGATAACAAAATAAACTAGCAATCTAGTTTTCTAATCTACTTTATGAGGCTGGATTTTTTTTTTAGAAAAGCTAAT
TTAAAATATTTAGAAATAGCTAGCCTATGTACAGCAAGTTTTCATGTCTTTTTTTAATAAATAGATTTCTAGGAGTCAGTATATATTTAA
TACTCTTCTTCCTTAAGAAAATAGAAGTTTAGGTCAAGTGTTAAGCTTTATCACTTTGACACTGTCCTTATCTCACAATGGAGGAATTTA
GAAAGGACCTTAACAGTTTCACAAACATAAATAAAGCCTTAGTCACACTAAATTAAAAAAAAAAATTCCTTAGGGATATCTTAGAGTAGT
AAAGTGACTTCCTCATATAAATAGTTTGAAAGGGTACTTAAGTTTTTCACCCAAATTGTGATATACAAAAAGGTTATTACCAAGCAACCT
ACATGTCAAGAAAGCCCCAGTTAGGAAGGAGCCACAGCATTTATCTTGTTTATAATTTCTTTGGTACTCCCACTGTTTAGAGCACAGGTT
GAACACCATGTTCATCTAAGCCTTATTAGTTAAAAAATGTGTTATGGCAAGGCAAATAAACTAGTTTAAAAAACATTAAATTTCACCATT
TGTAGAAATTCAAGTTTTATAATAGCTTGCTATAGCAGCTATAGATAAATTAGTCACCTTATTACAAAACTAAACCTTTGTAAACAAGTT
TAAATTTAATTTTCAAGAACCAAATTGCACTAGTCAAGAGTGTAGGAATTTTGAGAATCTAACAACTAGATTCAAAGTACTGTATCACTT
AGTATACCCTTTAAGGTAGCACTTATCCAGTCCAAAACTCCAGTGACAAAATTCCTAGTTTATCAAGATAAACACAGTAACACTGGATTA
AAGGAAAAACATTGCTATGGTATAGACTGTGGTTGGCTTCTATCCAGTAACCTTGGGAATGAAGACATCTTTGTAAACAAGTCCTGCTGT
TTCTTTAACAGCTAACATAGGAAATAATTAAATGTATTCTTTAGTGCCAATTGTAAGTTTTAAAATCAGAATGGCAGTGTAACTTGTGAA
TTGGCTAGGGCAATCAATCACAGCACTACTTTCTGTAAAACTTTAGTAGTTCAGTGATACCAGTTCTACCCAATCTTGGTGAATTCCAAC
TTGTTTGCTTAGTTATCTTCTTTAGTGTTTTCCTGGTGGTTTTTCAGTGCTCTTCGGTGGTGTCATAATGCCTCCATTGCACACTGGTGA

>95348_95348_4_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000586653_INTS8_chr8_95885601_ENST00000523731_length(amino acids)=243AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYI

--------------------------------------------------------------
>95348_95348_5_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000590967_INTS8_chr8_95885601_ENST00000447247_length(transcript)=979nt_BP=317nt
CGTCCGCAGAGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGGGAACCAGATCGG
CACCAAGTTTTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGGCGCTGCAGCTGGAGAGAAT
CAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCATGGACAGCGTGCG
GTCTGGGCCTTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTCTTCACTATTACCTCCAGGC
AGGAGCTGTGTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTGGCCATTTTATGTCAGTTCCTCAGAGA
AATTGACTACAAAACAGCGTTTAAATCTCTGCAAGAACAAAACAGTCATGATGCTATGGACTCCTACTACGACTACATATGGGATGTTAC
CATTTTGGAATACTTGACTTATCTTCATCATAAAAGAGGAGAAACAGATAAAAGACAAATTGCAATCAAAGCCATCGGCCAGACAGAGTT
GAATGCAAGCAATCCAGAAGAAGTGTTACAGCTGGCAGCGCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAATGGCAAAACTTTACTTTTA
AGCAGTTAAATTTTTTTAACTTTTATTTTTTAAACAATGGGCTAAAAATAAACAGTATTAAAAGGTTAAGTTTATATAATACATATGTAC
ACAATTAGTGGTGTTTTCTTTTCAGACAAAATACTGAAACAAATATTAGTTTAAAAACAAACTATACAGAAGACTTCATACCGTAACAAT

>95348_95348_5_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000590967_INTS8_chr8_95885601_ENST00000447247_length(amino acids)=226AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRG

--------------------------------------------------------------
>95348_95348_6_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000590967_INTS8_chr8_95885601_ENST00000523731_length(transcript)=2284nt_BP=317nt
CGTCCGCAGAGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGGGAACCAGATCGG
CACCAAGTTTTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGGCGCTGCAGCTGGAGAGAAT
CAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCATGGACAGCGTGCG
GTCTGGGCCTTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTCTTCACTATTACCTCCAGGC
AGGAGCTGTGTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTAATAAAACGAATGATAAAATGTTGTTC
TTTGCTGAATTGCCACACACAGGTGGCCATTTTATGTCAGTTCCTCAGAGAAATTGACTACAAAACAGCGTTTAAATCTCTGCAAGAACA
AAACAGTCATGATGCTATGGACTCCTACTACGACTACATATGGGATGTTACCATTTTGGAATACTTGACTTATCTTCATCATAAAAGAGG
AGAAACAGATAAAAGACAAATTGCAATCAAAGCCATCGGCCAGACAGAGTTGAATGCAAGCAATCCAGAAGAAGTGTTACAGCTGGCAGC
GCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAATGGCAAAACTTTACTTTTAAGCAGTTAAATTTTTTTAACTTTTATTTTTTAAACAATG
GGCTAAAAATAAACAGTATTAAAAGGTTAAGTTTATATAATACATATGTACACAATTAGTGGTGTTTTCTTTTCAGACAAAATACTGAAA
CAAATATTAGTTTAAAAACAAACTATACAGAAGACTTCATACCGTAACAATAAATGTATAGTTTCTTCAAAGGGAGAAGAGATTCACATA
TCTGATAACAAAATAAACTAGCAATCTAGTTTTCTAATCTACTTTATGAGGCTGGATTTTTTTTTTAGAAAAGCTAATTTAAAATATTTA
GAAATAGCTAGCCTATGTACAGCAAGTTTTCATGTCTTTTTTTAATAAATAGATTTCTAGGAGTCAGTATATATTTAATACTCTTCTTCC
TTAAGAAAATAGAAGTTTAGGTCAAGTGTTAAGCTTTATCACTTTGACACTGTCCTTATCTCACAATGGAGGAATTTAGAAAGGACCTTA
ACAGTTTCACAAACATAAATAAAGCCTTAGTCACACTAAATTAAAAAAAAAAATTCCTTAGGGATATCTTAGAGTAGTAAAGTGACTTCC
TCATATAAATAGTTTGAAAGGGTACTTAAGTTTTTCACCCAAATTGTGATATACAAAAAGGTTATTACCAAGCAACCTACATGTCAAGAA
AGCCCCAGTTAGGAAGGAGCCACAGCATTTATCTTGTTTATAATTTCTTTGGTACTCCCACTGTTTAGAGCACAGGTTGAACACCATGTT
CATCTAAGCCTTATTAGTTAAAAAATGTGTTATGGCAAGGCAAATAAACTAGTTTAAAAAACATTAAATTTCACCATTTGTAGAAATTCA
AGTTTTATAATAGCTTGCTATAGCAGCTATAGATAAATTAGTCACCTTATTACAAAACTAAACCTTTGTAAACAAGTTTAAATTTAATTT
TCAAGAACCAAATTGCACTAGTCAAGAGTGTAGGAATTTTGAGAATCTAACAACTAGATTCAAAGTACTGTATCACTTAGTATACCCTTT
AAGGTAGCACTTATCCAGTCCAAAACTCCAGTGACAAAATTCCTAGTTTATCAAGATAAACACAGTAACACTGGATTAAAGGAAAAACAT
TGCTATGGTATAGACTGTGGTTGGCTTCTATCCAGTAACCTTGGGAATGAAGACATCTTTGTAAACAAGTCCTGCTGTTTCTTTAACAGC
TAACATAGGAAATAATTAAATGTATTCTTTAGTGCCAATTGTAAGTTTTAAAATCAGAATGGCAGTGTAACTTGTGAATTGGCTAGGGCA
ATCAATCACAGCACTACTTTCTGTAAAACTTTAGTAGTTCAGTGATACCAGTTCTACCCAATCTTGGTGAATTCCAACTTGTTTGCTTAG
TTATCTTCTTTAGTGTTTTCCTGGTGGTTTTTCAGTGCTCTTCGGTGGTGTCATAATGCCTCCATTGCACACTGGTGACAACTGTCCCCC

>95348_95348_6_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000590967_INTS8_chr8_95885601_ENST00000523731_length(amino acids)=243AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYI

--------------------------------------------------------------
>95348_95348_7_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000591208_INTS8_chr8_95885601_ENST00000447247_length(transcript)=970nt_BP=308nt
AGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGGGAACCAGATCGGCACCAAGTT
TTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGGCGCTGCAGCTGGAGAGAATCAACGTCTA
CTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCATGGACAGCGTGCGGTCTGGGCC
TTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTCTTCACTATTACCTCCAGGCAGGAGCTGT
GTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTGGCCATTTTATGTCAGTTCCTCAGAGAAATTGACTA
CAAAACAGCGTTTAAATCTCTGCAAGAACAAAACAGTCATGATGCTATGGACTCCTACTACGACTACATATGGGATGTTACCATTTTGGA
ATACTTGACTTATCTTCATCATAAAAGAGGAGAAACAGATAAAAGACAAATTGCAATCAAAGCCATCGGCCAGACAGAGTTGAATGCAAG
CAATCCAGAAGAAGTGTTACAGCTGGCAGCGCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAATGGCAAAACTTTACTTTTAAGCAGTTAA
ATTTTTTTAACTTTTATTTTTTAAACAATGGGCTAAAAATAAACAGTATTAAAAGGTTAAGTTTATATAATACATATGTACACAATTAGT
GGTGTTTTCTTTTCAGACAAAATACTGAAACAAATATTAGTTTAAAAACAAACTATACAGAAGACTTCATACCGTAACAATAAATGTATA

>95348_95348_7_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000591208_INTS8_chr8_95885601_ENST00000447247_length(amino acids)=226AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRG

--------------------------------------------------------------
>95348_95348_8_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000591208_INTS8_chr8_95885601_ENST00000523731_length(transcript)=2275nt_BP=308nt
AGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGGGAACCAGATCGGCACCAAGTT
TTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGGCGCTGCAGCTGGAGAGAATCAACGTCTA
CTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCATGGACAGCGTGCGGTCTGGGCC
TTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTCTTCACTATTACCTCCAGGCAGGAGCTGT
GTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTAATAAAACGAATGATAAAATGTTGTTCTTTGCTGAA
TTGCCACACACAGGTGGCCATTTTATGTCAGTTCCTCAGAGAAATTGACTACAAAACAGCGTTTAAATCTCTGCAAGAACAAAACAGTCA
TGATGCTATGGACTCCTACTACGACTACATATGGGATGTTACCATTTTGGAATACTTGACTTATCTTCATCATAAAAGAGGAGAAACAGA
TAAAAGACAAATTGCAATCAAAGCCATCGGCCAGACAGAGTTGAATGCAAGCAATCCAGAAGAAGTGTTACAGCTGGCAGCGCAGAGAAG
GAAAAAAAAGTTTCTCCAAGCAATGGCAAAACTTTACTTTTAAGCAGTTAAATTTTTTTAACTTTTATTTTTTAAACAATGGGCTAAAAA
TAAACAGTATTAAAAGGTTAAGTTTATATAATACATATGTACACAATTAGTGGTGTTTTCTTTTCAGACAAAATACTGAAACAAATATTA
GTTTAAAAACAAACTATACAGAAGACTTCATACCGTAACAATAAATGTATAGTTTCTTCAAAGGGAGAAGAGATTCACATATCTGATAAC
AAAATAAACTAGCAATCTAGTTTTCTAATCTACTTTATGAGGCTGGATTTTTTTTTTAGAAAAGCTAATTTAAAATATTTAGAAATAGCT
AGCCTATGTACAGCAAGTTTTCATGTCTTTTTTTAATAAATAGATTTCTAGGAGTCAGTATATATTTAATACTCTTCTTCCTTAAGAAAA
TAGAAGTTTAGGTCAAGTGTTAAGCTTTATCACTTTGACACTGTCCTTATCTCACAATGGAGGAATTTAGAAAGGACCTTAACAGTTTCA
CAAACATAAATAAAGCCTTAGTCACACTAAATTAAAAAAAAAAATTCCTTAGGGATATCTTAGAGTAGTAAAGTGACTTCCTCATATAAA
TAGTTTGAAAGGGTACTTAAGTTTTTCACCCAAATTGTGATATACAAAAAGGTTATTACCAAGCAACCTACATGTCAAGAAAGCCCCAGT
TAGGAAGGAGCCACAGCATTTATCTTGTTTATAATTTCTTTGGTACTCCCACTGTTTAGAGCACAGGTTGAACACCATGTTCATCTAAGC
CTTATTAGTTAAAAAATGTGTTATGGCAAGGCAAATAAACTAGTTTAAAAAACATTAAATTTCACCATTTGTAGAAATTCAAGTTTTATA
ATAGCTTGCTATAGCAGCTATAGATAAATTAGTCACCTTATTACAAAACTAAACCTTTGTAAACAAGTTTAAATTTAATTTTCAAGAACC
AAATTGCACTAGTCAAGAGTGTAGGAATTTTGAGAATCTAACAACTAGATTCAAAGTACTGTATCACTTAGTATACCCTTTAAGGTAGCA
CTTATCCAGTCCAAAACTCCAGTGACAAAATTCCTAGTTTATCAAGATAAACACAGTAACACTGGATTAAAGGAAAAACATTGCTATGGT
ATAGACTGTGGTTGGCTTCTATCCAGTAACCTTGGGAATGAAGACATCTTTGTAAACAAGTCCTGCTGTTTCTTTAACAGCTAACATAGG
AAATAATTAAATGTATTCTTTAGTGCCAATTGTAAGTTTTAAAATCAGAATGGCAGTGTAACTTGTGAATTGGCTAGGGCAATCAATCAC
AGCACTACTTTCTGTAAAACTTTAGTAGTTCAGTGATACCAGTTCTACCCAATCTTGGTGAATTCCAACTTGTTTGCTTAGTTATCTTCT
TTAGTGTTTTCCTGGTGGTTTTTCAGTGCTCTTCGGTGGTGTCATAATGCCTCCATTGCACACTGGTGACAACTGTCCCCCTTTTCTGAA

>95348_95348_8_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000591208_INTS8_chr8_95885601_ENST00000523731_length(amino acids)=243AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYI

--------------------------------------------------------------
>95348_95348_9_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000591909_INTS8_chr8_95885601_ENST00000447247_length(transcript)=998nt_BP=336nt
GGCCCGCAGTTGCCGCTGTCGTCCGCAGAGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCC
AGTGCGGGAACCAGATCGGCACCAAGTTTTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGG
CGCTGCAGCTGGAGAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAG
GCACCATGGACAGCGTGCGGTCTGGGCCTTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTC
TTCACTATTACCTCCAGGCAGGAGCTGTGTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTGGCCATTT
TATGTCAGTTCCTCAGAGAAATTGACTACAAAACAGCGTTTAAATCTCTGCAAGAACAAAACAGTCATGATGCTATGGACTCCTACTACG
ACTACATATGGGATGTTACCATTTTGGAATACTTGACTTATCTTCATCATAAAAGAGGAGAAACAGATAAAAGACAAATTGCAATCAAAG
CCATCGGCCAGACAGAGTTGAATGCAAGCAATCCAGAAGAAGTGTTACAGCTGGCAGCGCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAA
TGGCAAAACTTTACTTTTAAGCAGTTAAATTTTTTTAACTTTTATTTTTTAAACAATGGGCTAAAAATAAACAGTATTAAAAGGTTAAGT
TTATATAATACATATGTACACAATTAGTGGTGTTTTCTTTTCAGACAAAATACTGAAACAAATATTAGTTTAAAAACAAACTATACAGAA
GACTTCATACCGTAACAATAAATGTATAGTTTCTTCAAAGGGAGAAGAGATTCACATATCTGATAACAAAATAAACTAGCAATCTAGTTT

>95348_95348_9_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000591909_INTS8_chr8_95885601_ENST00000447247_length(amino acids)=226AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRG

--------------------------------------------------------------
>95348_95348_10_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000591909_INTS8_chr8_95885601_ENST00000523731_length(transcript)=2303nt_BP=336nt
GGCCCGCAGTTGCCGCTGTCGTCCGCAGAGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCC
AGTGCGGGAACCAGATCGGCACCAAGTTTTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGG
CGCTGCAGCTGGAGAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAG
GCACCATGGACAGCGTGCGGTCTGGGCCTTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTC
TTCACTATTACCTCCAGGCAGGAGCTGTGTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTAATAAAAC
GAATGATAAAATGTTGTTCTTTGCTGAATTGCCACACACAGGTGGCCATTTTATGTCAGTTCCTCAGAGAAATTGACTACAAAACAGCGT
TTAAATCTCTGCAAGAACAAAACAGTCATGATGCTATGGACTCCTACTACGACTACATATGGGATGTTACCATTTTGGAATACTTGACTT
ATCTTCATCATAAAAGAGGAGAAACAGATAAAAGACAAATTGCAATCAAAGCCATCGGCCAGACAGAGTTGAATGCAAGCAATCCAGAAG
AAGTGTTACAGCTGGCAGCGCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAATGGCAAAACTTTACTTTTAAGCAGTTAAATTTTTTTAAC
TTTTATTTTTTAAACAATGGGCTAAAAATAAACAGTATTAAAAGGTTAAGTTTATATAATACATATGTACACAATTAGTGGTGTTTTCTT
TTCAGACAAAATACTGAAACAAATATTAGTTTAAAAACAAACTATACAGAAGACTTCATACCGTAACAATAAATGTATAGTTTCTTCAAA
GGGAGAAGAGATTCACATATCTGATAACAAAATAAACTAGCAATCTAGTTTTCTAATCTACTTTATGAGGCTGGATTTTTTTTTTAGAAA
AGCTAATTTAAAATATTTAGAAATAGCTAGCCTATGTACAGCAAGTTTTCATGTCTTTTTTTAATAAATAGATTTCTAGGAGTCAGTATA
TATTTAATACTCTTCTTCCTTAAGAAAATAGAAGTTTAGGTCAAGTGTTAAGCTTTATCACTTTGACACTGTCCTTATCTCACAATGGAG
GAATTTAGAAAGGACCTTAACAGTTTCACAAACATAAATAAAGCCTTAGTCACACTAAATTAAAAAAAAAAATTCCTTAGGGATATCTTA
GAGTAGTAAAGTGACTTCCTCATATAAATAGTTTGAAAGGGTACTTAAGTTTTTCACCCAAATTGTGATATACAAAAAGGTTATTACCAA
GCAACCTACATGTCAAGAAAGCCCCAGTTAGGAAGGAGCCACAGCATTTATCTTGTTTATAATTTCTTTGGTACTCCCACTGTTTAGAGC
ACAGGTTGAACACCATGTTCATCTAAGCCTTATTAGTTAAAAAATGTGTTATGGCAAGGCAAATAAACTAGTTTAAAAAACATTAAATTT
CACCATTTGTAGAAATTCAAGTTTTATAATAGCTTGCTATAGCAGCTATAGATAAATTAGTCACCTTATTACAAAACTAAACCTTTGTAA
ACAAGTTTAAATTTAATTTTCAAGAACCAAATTGCACTAGTCAAGAGTGTAGGAATTTTGAGAATCTAACAACTAGATTCAAAGTACTGT
ATCACTTAGTATACCCTTTAAGGTAGCACTTATCCAGTCCAAAACTCCAGTGACAAAATTCCTAGTTTATCAAGATAAACACAGTAACAC
TGGATTAAAGGAAAAACATTGCTATGGTATAGACTGTGGTTGGCTTCTATCCAGTAACCTTGGGAATGAAGACATCTTTGTAAACAAGTC
CTGCTGTTTCTTTAACAGCTAACATAGGAAATAATTAAATGTATTCTTTAGTGCCAATTGTAAGTTTTAAAATCAGAATGGCAGTGTAAC
TTGTGAATTGGCTAGGGCAATCAATCACAGCACTACTTTCTGTAAAACTTTAGTAGTTCAGTGATACCAGTTCTACCCAATCTTGGTGAA
TTCCAACTTGTTTGCTTAGTTATCTTCTTTAGTGTTTTCCTGGTGGTTTTTCAGTGCTCTTCGGTGGTGTCATAATGCCTCCATTGCACA

>95348_95348_10_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000591909_INTS8_chr8_95885601_ENST00000523731_length(amino acids)=243AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYI

--------------------------------------------------------------
>95348_95348_11_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000592683_INTS8_chr8_95885601_ENST00000447247_length(transcript)=985nt_BP=323nt
CGCTGTCGTCCGCAGAGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGGGAACCA
GATCGGCACCAAGTTTTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGGCGCTGCAGCTGGA
GAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCATGGACAG
CGTGCGGTCTGGGCCTTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTCTTCACTATTACCT
CCAGGCAGGAGCTGTGTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTGGCCATTTTATGTCAGTTCCT
CAGAGAAATTGACTACAAAACAGCGTTTAAATCTCTGCAAGAACAAAACAGTCATGATGCTATGGACTCCTACTACGACTACATATGGGA
TGTTACCATTTTGGAATACTTGACTTATCTTCATCATAAAAGAGGAGAAACAGATAAAAGACAAATTGCAATCAAAGCCATCGGCCAGAC
AGAGTTGAATGCAAGCAATCCAGAAGAAGTGTTACAGCTGGCAGCGCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAATGGCAAAACTTTA
CTTTTAAGCAGTTAAATTTTTTTAACTTTTATTTTTTAAACAATGGGCTAAAAATAAACAGTATTAAAAGGTTAAGTTTATATAATACAT
ATGTACACAATTAGTGGTGTTTTCTTTTCAGACAAAATACTGAAACAAATATTAGTTTAAAAACAAACTATACAGAAGACTTCATACCGT

>95348_95348_11_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000592683_INTS8_chr8_95885601_ENST00000447247_length(amino acids)=226AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRG

--------------------------------------------------------------
>95348_95348_12_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000592683_INTS8_chr8_95885601_ENST00000523731_length(transcript)=2290nt_BP=323nt
CGCTGTCGTCCGCAGAGCCAGTTCCTAGCGCAGAGCCGCGCCCGCCATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGGGAACCA
GATCGGCACCAAGTTTTGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCGGCGCTGCAGCTGGA
GAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTGCCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCATGGACAG
CGTGCGGTCTGGGCCTTTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGCAACGAATCAGTATTCAGCAGCTCTTCACTATTACCT
CCAGGCAGGAGCTGTGTGTTCTGACTTCTTTAACAAGGCTGTGCCCCCTGATGTTTATACAGACCAGGTAATAAAACGAATGATAAAATG
TTGTTCTTTGCTGAATTGCCACACACAGGTGGCCATTTTATGTCAGTTCCTCAGAGAAATTGACTACAAAACAGCGTTTAAATCTCTGCA
AGAACAAAACAGTCATGATGCTATGGACTCCTACTACGACTACATATGGGATGTTACCATTTTGGAATACTTGACTTATCTTCATCATAA
AAGAGGAGAAACAGATAAAAGACAAATTGCAATCAAAGCCATCGGCCAGACAGAGTTGAATGCAAGCAATCCAGAAGAAGTGTTACAGCT
GGCAGCGCAGAGAAGGAAAAAAAAGTTTCTCCAAGCAATGGCAAAACTTTACTTTTAAGCAGTTAAATTTTTTTAACTTTTATTTTTTAA
ACAATGGGCTAAAAATAAACAGTATTAAAAGGTTAAGTTTATATAATACATATGTACACAATTAGTGGTGTTTTCTTTTCAGACAAAATA
CTGAAACAAATATTAGTTTAAAAACAAACTATACAGAAGACTTCATACCGTAACAATAAATGTATAGTTTCTTCAAAGGGAGAAGAGATT
CACATATCTGATAACAAAATAAACTAGCAATCTAGTTTTCTAATCTACTTTATGAGGCTGGATTTTTTTTTTAGAAAAGCTAATTTAAAA
TATTTAGAAATAGCTAGCCTATGTACAGCAAGTTTTCATGTCTTTTTTTAATAAATAGATTTCTAGGAGTCAGTATATATTTAATACTCT
TCTTCCTTAAGAAAATAGAAGTTTAGGTCAAGTGTTAAGCTTTATCACTTTGACACTGTCCTTATCTCACAATGGAGGAATTTAGAAAGG
ACCTTAACAGTTTCACAAACATAAATAAAGCCTTAGTCACACTAAATTAAAAAAAAAAATTCCTTAGGGATATCTTAGAGTAGTAAAGTG
ACTTCCTCATATAAATAGTTTGAAAGGGTACTTAAGTTTTTCACCCAAATTGTGATATACAAAAAGGTTATTACCAAGCAACCTACATGT
CAAGAAAGCCCCAGTTAGGAAGGAGCCACAGCATTTATCTTGTTTATAATTTCTTTGGTACTCCCACTGTTTAGAGCACAGGTTGAACAC
CATGTTCATCTAAGCCTTATTAGTTAAAAAATGTGTTATGGCAAGGCAAATAAACTAGTTTAAAAAACATTAAATTTCACCATTTGTAGA
AATTCAAGTTTTATAATAGCTTGCTATAGCAGCTATAGATAAATTAGTCACCTTATTACAAAACTAAACCTTTGTAAACAAGTTTAAATT
TAATTTTCAAGAACCAAATTGCACTAGTCAAGAGTGTAGGAATTTTGAGAATCTAACAACTAGATTCAAAGTACTGTATCACTTAGTATA
CCCTTTAAGGTAGCACTTATCCAGTCCAAAACTCCAGTGACAAAATTCCTAGTTTATCAAGATAAACACAGTAACACTGGATTAAAGGAA
AAACATTGCTATGGTATAGACTGTGGTTGGCTTCTATCCAGTAACCTTGGGAATGAAGACATCTTTGTAAACAAGTCCTGCTGTTTCTTT
AACAGCTAACATAGGAAATAATTAAATGTATTCTTTAGTGCCAATTGTAAGTTTTAAAATCAGAATGGCAGTGTAACTTGTGAATTGGCT
AGGGCAATCAATCACAGCACTACTTTCTGTAAAACTTTAGTAGTTCAGTGATACCAGTTCTACCCAATCTTGGTGAATTCCAACTTGTTT
GCTTAGTTATCTTCTTTAGTGTTTTCCTGGTGGTTTTTCAGTGCTCTTCGGTGGTGTCATAATGCCTCCATTGCACACTGGTGACAACTG

>95348_95348_12_TUBB6-INTS8_TUBB6_chr18_12311052_ENST00000592683_INTS8_chr8_95885601_ENST00000523731_length(amino acids)=243AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYI

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Fusion Gene PPI Analysis for TUBB6-INTS8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TUBB6-INTS8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TUBB6-INTS8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource