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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TUBB-MTCH1 (FusionGDB2 ID:95360)

Fusion Gene Summary for TUBB-MTCH1

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBB-MTCH1
Fusion gene ID: 95360
HgeneTgene
Gene symbol

TUBB

MTCH1

Gene ID

203068

23787

Gene nametubulin beta class Imitochondrial carrier 1
SynonymsCDCBM6|CSCSC1|M40|OK/SW-cl.56|TUBB1|TUBB5CGI-64|PIG60|PSAP|SLC25A49
Cytomap

6p21.33

6p21.2

Type of geneprotein-codingprotein-coding
Descriptiontubulin beta chainbeta Ib tubulinepididymis secretory sperm binding proteintubulin beta-1 chaintubulin beta-5 chaintubulin, beta polypeptidemitochondrial carrier homolog 1cell proliferation-inducing protein 60presenilin-associated proteinsolute carrier family 25, member 49
Modification date2020032720200313
UniProtAcc.

Q9NZJ7

Ensembl transtripts involved in fusion geneENST00000327892, ENST00000435534, 
ENST00000330914, ENST00000383564, 
ENST00000396384, ENST00000396389, 
ENST00000400530, ENST00000400531, 
ENST00000400534, ENST00000412136, 
ENST00000413547, ENST00000419551, 
ENST00000419792, ENST00000420400, 
ENST00000420618, ENST00000421473, 
ENST00000422650, ENST00000422674, 
ENST00000424734, ENST00000425102, 
ENST00000425136, ENST00000426754, 
ENST00000427480, ENST00000432462, 
ENST00000435546, ENST00000436335, 
ENST00000436628, ENST00000437490, 
ENST00000444441, ENST00000446385, 
ENST00000453350, ENST00000454454, 
ENST00000454620, ENST00000547690, 
ENST00000547695, ENST00000548023, 
ENST00000549614, ENST00000549654, 
ENST00000549902, ENST00000551208, 
ENST00000373616, ENST00000373627, 
ENST00000471737, ENST00000538808, 
Fusion gene scores* DoF score12 X 11 X 6=79212 X 13 X 3=468
# samples 1413
** MAII scorelog2(14/792*10)=-2.50007360313464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/468*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUBB [Title/Abstract] AND MTCH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTUBB(30688300)-MTCH1(36936123), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTUBB

GO:0009987

cellular process

19567321


check buttonFusion gene breakpoints across TUBB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MTCH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACN305548TUBBchr6

30688300

+MTCH1chr6

36936123

-


Top

Fusion Gene ORF analysis for TUBB-MTCH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000327892ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
5CDS-3UTRENST00000327892ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
5CDS-3UTRENST00000435534ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
5CDS-3UTRENST00000435534ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
5CDS-intronENST00000327892ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
5CDS-intronENST00000327892ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
5CDS-intronENST00000435534ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
5CDS-intronENST00000435534ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000330914ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000330914ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000383564ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000383564ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000396384ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000396384ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000396389ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000396389ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000400530ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000400530ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000400531ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000400531ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000400534ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000400534ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000412136ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000412136ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000413547ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000413547ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000419551ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000419551ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000419792ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000419792ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000420400ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000420400ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000420618ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000420618ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000421473ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000421473ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000422650ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000422650ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000422674ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000422674ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000424734ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000424734ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000425102ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000425102ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000425136ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000425136ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000426754ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000426754ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000427480ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000427480ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000432462ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000432462ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000435546ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000435546ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000436335ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000436335ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000436628ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000436628ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000437490ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000437490ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000444441ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000444441ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000446385ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000446385ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000453350ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000453350ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000454454ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000454454ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000454620ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000454620ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000547690ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000547690ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000547695ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000547695ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000548023ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000548023ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000549614ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000549614ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000549654ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000549654ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000549902ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000549902ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000551208ENST00000373616TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-3UTRENST00000551208ENST00000373627TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000330914ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000330914ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000383564ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000383564ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000396384ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000396384ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000396389ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000396389ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000400530ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000400530ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000400531ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000400531ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000400534ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000400534ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000412136ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000412136ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000413547ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000413547ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000419551ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000419551ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000419792ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000419792ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000420400ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000420400ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000420618ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000420618ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000421473ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000421473ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000422650ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000422650ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000422674ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000422674ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000424734ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000424734ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000425102ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000425102ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000425136ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000425136ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000426754ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000426754ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000427480ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000427480ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000432462ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000432462ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000435546ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000435546ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000436335ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000436335ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000436628ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000436628ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000437490ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000437490ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000444441ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000444441ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000446385ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000446385ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000453350ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000453350ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000454454ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000454454ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000454620ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000454620ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000547690ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000547690ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000547695ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000547695ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000548023ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000548023ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000549614ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000549614ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000549654ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000549654ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000549902ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000549902ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000551208ENST00000471737TUBBchr6

30688300

+MTCH1chr6

36936123

-
intron-intronENST00000551208ENST00000538808TUBBchr6

30688300

+MTCH1chr6

36936123

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TUBB-MTCH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TUBB-MTCH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30688300/:36936123)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MTCH1

Q9NZJ7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Potential mitochondrial transporter. May play a role in apoptosis. {ECO:0000269|PubMed:12377771}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TUBB-MTCH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TUBB-MTCH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TUBB-MTCH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TUBB-MTCH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource